FMO5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.45323506
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.45323506
3L-phenylalanine metabolic process (GO:0006558)7.11941638
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.11941638
5aromatic amino acid family catabolic process (GO:0009074)6.77309542
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.26128965
7epoxygenase P450 pathway (GO:0019373)6.19623516
8indole-containing compound catabolic process (GO:0042436)6.17794093
9indolalkylamine catabolic process (GO:0046218)6.17794093
10tryptophan catabolic process (GO:0006569)6.17794093
11kynurenine metabolic process (GO:0070189)5.99201445
12bile acid biosynthetic process (GO:0006699)5.87222012
13tryptophan metabolic process (GO:0006568)5.79933721
14urea cycle (GO:0000050)5.66537033
15urea metabolic process (GO:0019627)5.66537033
16glyoxylate metabolic process (GO:0046487)5.65136511
17alpha-linolenic acid metabolic process (GO:0036109)5.55050828
18high-density lipoprotein particle remodeling (GO:0034375)5.38699011
19negative regulation of fibrinolysis (GO:0051918)5.37994185
20complement activation, alternative pathway (GO:0006957)5.34252990
21regulation of protein activation cascade (GO:2000257)5.28567687
22negative regulation of protein activation cascade (GO:2000258)5.27082908
23cysteine metabolic process (GO:0006534)5.21930199
24nitrogen cycle metabolic process (GO:0071941)5.21236846
25sulfur amino acid catabolic process (GO:0000098)5.20533484
26regulation of fibrinolysis (GO:0051917)5.20350767
27peptidyl-glutamic acid carboxylation (GO:0017187)5.19811184
28protein carboxylation (GO:0018214)5.19811184
29omega-hydroxylase P450 pathway (GO:0097267)5.13864044
30bile acid metabolic process (GO:0008206)5.01597961
31regulation of triglyceride catabolic process (GO:0010896)4.98289331
32intestinal cholesterol absorption (GO:0030299)4.98209855
33positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.97080732
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96604967
35serine family amino acid catabolic process (GO:0009071)4.96180931
36regulation of complement activation (GO:0030449)4.95956033
37aromatic amino acid family metabolic process (GO:0009072)4.90253640
38regulation of cholesterol esterification (GO:0010872)4.77255601
39reverse cholesterol transport (GO:0043691)4.76818298
40homocysteine metabolic process (GO:0050667)4.76621918
41tyrosine metabolic process (GO:0006570)4.71337839
42protein-lipid complex assembly (GO:0065005)4.66206085
43protein-lipid complex remodeling (GO:0034368)4.65772824
44macromolecular complex remodeling (GO:0034367)4.65772824
45plasma lipoprotein particle remodeling (GO:0034369)4.65772824
46amino-acid betaine metabolic process (GO:0006577)4.60953575
47drug metabolic process (GO:0017144)4.60063271
48phospholipid efflux (GO:0033700)4.59646257
49ethanol metabolic process (GO:0006067)4.58999188
50lysine catabolic process (GO:0006554)4.58176615
51lysine metabolic process (GO:0006553)4.58176615
52acylglycerol homeostasis (GO:0055090)4.57161697
53triglyceride homeostasis (GO:0070328)4.57161697
54alpha-amino acid catabolic process (GO:1901606)4.56946389
55negative regulation of cholesterol transport (GO:0032375)4.49990549
56negative regulation of sterol transport (GO:0032372)4.49990549
57bile acid and bile salt transport (GO:0015721)4.40171491
58regulation of humoral immune response (GO:0002920)4.38420015
59indolalkylamine metabolic process (GO:0006586)4.36448840
60cellular glucuronidation (GO:0052695)4.32628148
61cellular ketone body metabolic process (GO:0046950)4.31136588
62coenzyme catabolic process (GO:0009109)4.28968934
63amine catabolic process (GO:0009310)4.27992146
64cellular biogenic amine catabolic process (GO:0042402)4.27992146
65negative regulation of hemostasis (GO:1900047)4.27219795
66negative regulation of blood coagulation (GO:0030195)4.27219795
67negative regulation of complement activation (GO:0045916)4.26617690
68regulation of plasminogen activation (GO:0010755)4.26050280
69protein-lipid complex subunit organization (GO:0071825)4.25353691
70plasma lipoprotein particle clearance (GO:0034381)4.23240715
71cellular amino acid catabolic process (GO:0009063)4.20892954
72glycine metabolic process (GO:0006544)4.19374800
73drug catabolic process (GO:0042737)4.18982912
74cholesterol efflux (GO:0033344)4.18226191
75imidazole-containing compound metabolic process (GO:0052803)4.18051581
76glutamate metabolic process (GO:0006536)4.15926203
77benzene-containing compound metabolic process (GO:0042537)4.15592695
78ethanol oxidation (GO:0006069)4.09739442
79serine family amino acid metabolic process (GO:0009069)4.05763317
80regulation of apoptotic cell clearance (GO:2000425)4.03794073
81cellular modified amino acid catabolic process (GO:0042219)4.01091806
82arginine metabolic process (GO:0006525)3.98503927
83lipoprotein metabolic process (GO:0042157)3.97742411
84plasma lipoprotein particle assembly (GO:0034377)3.95158600
85acute-phase response (GO:0006953)3.93460050
86negative regulation of coagulation (GO:0050819)3.92919973
87dicarboxylic acid biosynthetic process (GO:0043650)3.92388357
88fibrinolysis (GO:0042730)3.91283857
89positive regulation of lipoprotein lipase activity (GO:0051006)3.89477660
90positive regulation of triglyceride lipase activity (GO:0061365)3.89477660
91intestinal absorption (GO:0050892)3.88996898
92glucuronate metabolic process (GO:0019585)3.86316717
93uronic acid metabolic process (GO:0006063)3.86316717
94oxidative demethylation (GO:0070989)3.85497940
95aldehyde catabolic process (GO:0046185)3.85072946
96serine family amino acid biosynthetic process (GO:0009070)3.81645039
97regulation of bile acid biosynthetic process (GO:0070857)3.80545779
98low-density lipoprotein particle remodeling (GO:0034374)3.79185895
99negative regulation of wound healing (GO:0061045)3.76707784
100phospholipid homeostasis (GO:0055091)3.75765208
101cholesterol homeostasis (GO:0042632)3.75079532
102positive regulation of lipid catabolic process (GO:0050996)3.74938865
103complement activation, classical pathway (GO:0006958)3.74523356
104negative regulation of lipase activity (GO:0060192)3.73161623
105ketone body metabolic process (GO:1902224)3.72680511
106very-low-density lipoprotein particle assembly (GO:0034379)3.72031036
107positive regulation of blood coagulation (GO:0030194)3.71152391
108positive regulation of hemostasis (GO:1900048)3.71152391
109organic acid catabolic process (GO:0016054)3.70717771
110carboxylic acid catabolic process (GO:0046395)3.70717771
111complement activation (GO:0006956)3.70256540
112exogenous drug catabolic process (GO:0042738)3.70202733
113blood coagulation, intrinsic pathway (GO:0007597)3.70187355
114sterol homeostasis (GO:0055092)3.68986977
115cytolysis (GO:0019835)3.68568103
116cofactor catabolic process (GO:0051187)3.67058969
117flavonoid metabolic process (GO:0009812)3.66987074
118regulation of cholesterol homeostasis (GO:2000188)3.66684267
119protein activation cascade (GO:0072376)3.65909636
120acetyl-CoA metabolic process (GO:0006084)3.64220828
121short-chain fatty acid metabolic process (GO:0046459)3.63536396
122response to nitrosative stress (GO:0051409)3.62662393
123plasma lipoprotein particle organization (GO:0071827)3.56413654
124regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.52243555
125sterol transport (GO:0015918)3.48569977
126cholesterol transport (GO:0030301)3.48569977
127negative regulation of humoral immune response (GO:0002921)3.46642438
128positive regulation of coagulation (GO:0050820)3.43399616
129killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.37961489
130disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.37961489
131phenylpropanoid metabolic process (GO:0009698)3.37010279
132drug transmembrane transport (GO:0006855)3.35824696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.20636244
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.05206709
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.86731428
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.41116591
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.19420036
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.93765001
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80573591
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03736993
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.86529264
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02434112
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6920921
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98138148
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94864180
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79683259
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62449611
16TCF4_18268006_ChIP-ChIP_LS174T_Human1.62273072
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.60790790
18CLOCK_20551151_ChIP-Seq_293T_Human1.55369965
19HTT_18923047_ChIP-ChIP_STHdh_Human1.51965890
20GATA1_22025678_ChIP-Seq_K562_Human1.48929066
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47698094
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47136982
23VDR_22108803_ChIP-Seq_LS180_Human1.46360744
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39584636
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.34834677
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33043322
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32538114
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31097122
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30162216
30IGF1R_20145208_ChIP-Seq_DFB_Human1.27971169
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26996266
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.26722824
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24036395
34GBX2_23144817_ChIP-Seq_PC3_Human1.23451815
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20318187
36ER_23166858_ChIP-Seq_MCF-7_Human1.20120049
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18690818
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.18173439
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.17890366
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17814172
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14674725
42RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14046413
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13270777
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10942811
45TP53_16413492_ChIP-PET_HCT116_Human1.08697781
46TCF4_22108803_ChIP-Seq_LS180_Human1.06995199
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06105718
48STAT3_23295773_ChIP-Seq_U87_Human1.04310089
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01481618
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97696286
51CRX_20693478_ChIP-Seq_RETINA_Mouse0.97203060
52NANOG_19829295_ChIP-Seq_ESCs_Human0.95562534
53SOX2_19829295_ChIP-Seq_ESCs_Human0.95562534
54IRF8_22096565_ChIP-ChIP_GC-B_Human0.95529560
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94616020
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93856951
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93735001
58ZNF274_21170338_ChIP-Seq_K562_Hela0.93135289
59TCF4_23295773_ChIP-Seq_U87_Human0.92981212
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91743365
61CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91078272
62KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90995551
63SMAD1_18555785_Chip-Seq_ESCs_Mouse0.90534309
64* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89357696
65* GATA4_25053715_ChIP-Seq_YYC3_Human0.89203850
66RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88447668
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88441424
68OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87818551
69ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86976643
70FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86724981
71SMAD3_21741376_ChIP-Seq_HESCs_Human0.85991517
72OCT4_18555785_Chip-Seq_ESCs_Mouse0.85860357
73AHR_22903824_ChIP-Seq_MCF-7_Human0.85047163
74ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84803335
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84423961
76AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84222786
77STAT3_18555785_Chip-Seq_ESCs_Mouse0.83791917
78P300_19829295_ChIP-Seq_ESCs_Human0.83513785
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82889983
80NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82639077
81ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82560692
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82299607
83ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81511540
84TP63_23658742_ChIP-Seq_EP156T_Human0.81473552
85CTCF_18555785_Chip-Seq_ESCs_Mouse0.81039990
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.80958557
87KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77752364
88ESR2_21235772_ChIP-Seq_MCF-7_Human0.77297678
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74992299
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73880387
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73609991
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72813892
93NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72009035
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72009035
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71101724
96CDX2_20551321_ChIP-Seq_CACO-2_Human0.70595827
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69886011
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68559955
99RARA_24833708_ChIP-Seq_LIVER_Mouse0.68252731
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66798010
101* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64279013
102RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64215256
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63928807
104CEBPB_22108803_ChIP-Seq_LS180_Human0.60545981
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.59032788
106ESR1_21235772_ChIP-Seq_MCF-7_Human0.59023602
107RARB_24833708_ChIP-Seq_LIVER_Mouse0.58997801
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56501759
109AR_20517297_ChIP-Seq_VCAP_Human0.55948816
110EGR1_19032775_ChIP-ChIP_M12_Human0.55803519
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55640770
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.55517568
113ZNF263_19887448_ChIP-Seq_K562_Human0.55351602
114STAT1_17558387_ChIP-Seq_HELA_Human0.52912550
115PPAR_26484153_Chip-Seq_NCI-H1993_Human0.52846848
116MYC_19915707_ChIP-ChIP_AK7_Human0.52418503
117LXR_22292898_ChIP-Seq_THP-1_Human0.52007636
118ESET_19884257_ChIP-Seq_ESCs_Mouse0.50769074
119CBP_21632823_ChIP-Seq_H3396_Human0.50754907
120TAF15_26573619_Chip-Seq_HEK293_Human0.49239580
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.49198737
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48722290
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.48042577
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47015746
125P53_21459846_ChIP-Seq_SAOS-2_Human0.46992061
126GATA2_19941826_ChIP-Seq_K562_Human0.46823087
127SOX2_20726797_ChIP-Seq_SW620_Human0.46547241
128BCAT_22108803_ChIP-Seq_LS180_Human0.45907016
129GATA6_25053715_ChIP-Seq_YYC3_Human0.45725384
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45654378
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44523932
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43832007
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.43283516
134GATA1_19941826_ChIP-Seq_K562_Human0.42929804
135TAF2_19829295_ChIP-Seq_ESCs_Human0.42825607
136* GATA1_19941827_ChIP-Seq_MEL_Mouse0.42622308
137* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42478594
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41465609
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.41461617
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39528258
141CDX2_22108803_ChIP-Seq_LS180_Human0.37825773
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.36739384
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.36128399
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.35948867
145GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.35789936
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35731083
147GATA3_24758297_ChIP-Seq_MCF-7_Human0.35683985
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.35372977
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.35357203
150GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.35254422
151FOXH1_21741376_ChIP-Seq_EPCs_Human0.35253256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.12668945
2MP0005360_urolithiasis7.64988035
3MP0005085_abnormal_gallbladder_physiolo6.38242524
4MP0005365_abnormal_bile_salt6.07445724
5MP0008875_abnormal_xenobiotic_pharmacok5.27012581
6MP0003806_abnormal_nucleotide_metabolis4.08659079
7MP0003252_abnormal_bile_duct3.95138653
8MP0010329_abnormal_lipoprotein_level3.55144623
9MP0009840_abnormal_foam_cell3.27512686
10MP0005083_abnormal_biliary_tract2.91560529
11MP0005332_abnormal_amino_acid2.77664692
12MP0001666_abnormal_nutrient_absorption2.75940196
13MP0003195_calcinosis2.65164606
14MP0003191_abnormal_cellular_cholesterol2.33998103
15MP0004019_abnormal_vitamin_homeostasis2.25233533
16MP0000609_abnormal_liver_physiology2.13761794
17MP0002118_abnormal_lipid_homeostasis2.08808844
18MP0002138_abnormal_hepatobiliary_system1.97360017
19MP0003868_abnormal_feces_composition1.90200107
20MP0005319_abnormal_enzyme/_coenzyme1.82406662
21MP0001764_abnormal_homeostasis1.66235226
22MP0009697_abnormal_copulation1.58874585
23MP0005584_abnormal_enzyme/coenzyme_acti1.54963707
24MP0003122_maternal_imprinting1.48171472
25MP0005451_abnormal_body_composition1.46667898
26MP0003011_delayed_dark_adaptation1.43613216
27MP0003183_abnormal_peptide_metabolism1.36742073
28MP0009643_abnormal_urine_homeostasis1.31364136
29MP0003186_abnormal_redox_activity1.26615419
30MP0003656_abnormal_erythrocyte_physiolo1.21501737
31MP0000598_abnormal_liver_morphology1.14219793
32MP0002254_reproductive_system_inflammat1.12573809
33MP0004043_abnormal_pH_regulation1.10634946
34MP0009764_decreased_sensitivity_to1.10584025
35MP0005647_abnormal_sex_gland1.10028519
36MP0003705_abnormal_hypodermis_morpholog1.04449865
37MP0009763_increased_sensitivity_to1.00746815
38MP0006054_spinal_hemorrhage1.00563565
39MP0000604_amyloidosis1.00241709
40MP0005636_abnormal_mineral_homeostasis0.95110907
41MP0005670_abnormal_white_adipose0.93258661
42MP0008469_abnormal_protein_level0.91478599
43MP0010368_abnormal_lymphatic_system0.89063965
44MP0009642_abnormal_blood_homeostasis0.87405371
45MP0002876_abnormal_thyroid_physiology0.85839418
46MP0005084_abnormal_gallbladder_morpholo0.85081855
47MP0005408_hypopigmentation0.82915833
48MP0009765_abnormal_xenobiotic_induced0.79719510
49MP0005376_homeostasis/metabolism_phenot0.78899224
50MP0006036_abnormal_mitochondrial_physio0.77921108
51MP0003879_abnormal_hair_cell0.77335138
52MP0005551_abnormal_eye_electrophysiolog0.76330021
53MP0002078_abnormal_glucose_homeostasis0.74881179
54MP0002971_abnormal_brown_adipose0.72874157
55MP0009780_abnormal_chondrocyte_physiolo0.72597020
56MP0003950_abnormal_plasma_membrane0.72004246
57MP0003172_abnormal_lysosome_physiology0.71968857
58MP0005409_darkened_coat_color0.70643414
59MP0001915_intracranial_hemorrhage0.69562336
60MP0005334_abnormal_fat_pad0.69430742
61MP0005220_abnormal_exocrine_pancreas0.69072423
62MP0004130_abnormal_muscle_cell0.68669411
63MP0001756_abnormal_urination0.68455369
64MP0005535_abnormal_body_temperature0.67053302
65MP0003690_abnormal_glial_cell0.66367479
66MP0001661_extended_life_span0.63032911
67MP0005266_abnormal_metabolism0.62930040
68MP0000566_synostosis0.60042793
69MP0009053_abnormal_anal_canal0.59188946
70MP0010155_abnormal_intestine_physiology0.58554770
71MP0005410_abnormal_fertilization0.58513810
72MP0002089_abnormal_postnatal_growth/wei0.57933274
73MP0005164_abnormal_response_to0.57623875
74MP0002822_catalepsy0.57544023
75MP0005448_abnormal_energy_balance0.56780220
76MP0003329_amyloid_beta_deposits0.56650553
77MP0005464_abnormal_platelet_physiology0.55750736
78MP0000371_diluted_coat_color0.54874075
79MP0003724_increased_susceptibility_to0.54761064
80MP0005646_abnormal_pituitary_gland0.54534120
81MP0001986_abnormal_taste_sensitivity0.53489991
82MP0000639_abnormal_adrenal_gland0.53328314
83MP0004147_increased_porphyrin_level0.52970055
84MP0002136_abnormal_kidney_physiology0.52536143
85MP0006035_abnormal_mitochondrial_morpho0.50515899
86MP0001765_abnormal_ion_homeostasis0.50313915
87MP0003638_abnormal_response/metabolism_0.48940324
88MP0004381_abnormal_hair_follicle0.48934262
89MP0003436_decreased_susceptibility_to0.48332476
90MP0004782_abnormal_surfactant_physiolog0.47226828
91MP0002282_abnormal_trachea_morphology0.47065674
92MP0003866_abnormal_defecation0.47055066
93MP0002928_abnormal_bile_duct0.46819762
94MP0009785_altered_susceptibility_to0.46709870
95MP0005395_other_phenotype0.45473572
96MP0005666_abnormal_adipose_tissue0.45294685
97MP0003718_maternal_effect0.44752864
98MP0008873_increased_physiological_sensi0.44124431
99MP0002796_impaired_skin_barrier0.44058372
100MP0002909_abnormal_adrenal_gland0.44038259
101MP0002837_dystrophic_cardiac_calcinosis0.43927018
102MP0008874_decreased_physiological_sensi0.43922524
103MP0001324_abnormal_eye_pigmentation0.43895072
104MP0003878_abnormal_ear_physiology0.43800349
105MP0005377_hearing/vestibular/ear_phenot0.43800349
106MP0005166_decreased_susceptibility_to0.42799902
107MP0001501_abnormal_sleep_pattern0.42131959
108MP0009384_cardiac_valve_regurgitation0.41291162
109MP0000579_abnormal_nail_morphology0.39674845
110MP0003075_altered_response_to0.39577677
111MP0003953_abnormal_hormone_level0.39340002
112MP0002135_abnormal_kidney_morphology0.39079452
113MP0008872_abnormal_physiological_respon0.37791290
114MP0003633_abnormal_nervous_system0.37174392
115MP0000230_abnormal_systemic_arterial0.37021401
116MP0005248_abnormal_Harderian_gland0.36398380
117MP0003632_abnormal_nervous_system0.36251639
118MP0001853_heart_inflammation0.36016824
119MP0003943_abnormal_hepatobiliary_system0.35671036
120MP0009115_abnormal_fat_cell0.35566898
121MP0000249_abnormal_blood_vessel0.33948051
122MP0001845_abnormal_inflammatory_respons0.32448938
123MP0006082_CNS_inflammation0.32283269
124MP0004883_abnormal_blood_vessel0.30347909
125MP0002970_abnormal_white_adipose0.29386048
126MP0002132_abnormal_respiratory_system0.29333853
127MP0002060_abnormal_skin_morphology0.28776939
128MP0001243_abnormal_dermal_layer0.28265772
129MP0001881_abnormal_mammary_gland0.28117099
130MP0005167_abnormal_blood-brain_barrier0.27977352
131MP0004264_abnormal_extraembryonic_tissu0.27828537
132MP0002168_other_aberrant_phenotype0.27621674
133MP0005058_abnormal_lysosome_morphology0.27251673

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.28313079
2Deep venous thrombosis (HP:0002625)7.21053865
3Intrahepatic cholestasis (HP:0001406)7.18646222
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.68711959
5Hypobetalipoproteinemia (HP:0003563)6.45450401
6Prolonged partial thromboplastin time (HP:0003645)6.42744211
7Xanthomatosis (HP:0000991)6.23879764
8Complement deficiency (HP:0004431)5.48477844
9Hyperlipoproteinemia (HP:0010980)5.45646660
10Hypolipoproteinemia (HP:0010981)4.79369242
11Joint hemorrhage (HP:0005261)4.64954402
12Hyperammonemia (HP:0001987)4.59941653
13Epidermoid cyst (HP:0200040)4.51501632
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.38852968
15Hyperglycinemia (HP:0002154)4.38832566
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.35856046
17Abnormality of the common coagulation pathway (HP:0010990)4.35428144
18Ketosis (HP:0001946)4.23198573
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.20566859
20Fat malabsorption (HP:0002630)4.20432060
21Abnormality of methionine metabolism (HP:0010901)4.16817848
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15259354
23Hypoalphalipoproteinemia (HP:0003233)4.13431765
24Hyperglycinuria (HP:0003108)4.04128432
25Abnormality of complement system (HP:0005339)3.99083479
26Abnormality of glycine metabolism (HP:0010895)3.97252632
27Abnormality of serine family amino acid metabolism (HP:0010894)3.97252632
28Conjugated hyperbilirubinemia (HP:0002908)3.86948174
29Hypoglycemic coma (HP:0001325)3.84227128
30Abnormality of pyrimidine metabolism (HP:0004353)3.82176368
31Abnormality of the intrinsic pathway (HP:0010989)3.63306066
32Hypercholesterolemia (HP:0003124)3.56294511
33Abnormality of fatty-acid metabolism (HP:0004359)3.39468760
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39327514
35Hyperbilirubinemia (HP:0002904)3.32011584
36Steatorrhea (HP:0002570)3.14410785
37Abnormality of nucleobase metabolism (HP:0010932)3.12836407
38Abnormality of serum amino acid levels (HP:0003112)3.03054337
39Ketoacidosis (HP:0001993)3.02856934
40Delayed CNS myelination (HP:0002188)3.00464240
41Spontaneous abortion (HP:0005268)2.96627569
42Myocardial infarction (HP:0001658)2.90217129
43Hepatocellular carcinoma (HP:0001402)2.88727846
44Systemic lupus erythematosus (HP:0002725)2.87326181
45Purpura (HP:0000979)2.83277572
46Hypochromic microcytic anemia (HP:0004840)2.80755716
47Metabolic acidosis (HP:0001942)2.78620397
48Abnormality of purine metabolism (HP:0004352)2.78166427
49Skin nodule (HP:0200036)2.74521238
50Vascular calcification (HP:0004934)2.66114473
51Acanthocytosis (HP:0001927)2.66072983
52Lethargy (HP:0001254)2.60868548
53Dicarboxylic aciduria (HP:0003215)2.58923448
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58923448
55Osteomalacia (HP:0002749)2.54333094
56Malnutrition (HP:0004395)2.51891777
57Fair hair (HP:0002286)2.51869080
58Recurrent gram-negative bacterial infections (HP:0005420)2.50041670
59Gout (HP:0001997)2.48399533
60Hypoglycemic seizures (HP:0002173)2.47410366
61Facial shape deformation (HP:0011334)2.47003509
62Potter facies (HP:0002009)2.47003509
63Glomerulonephritis (HP:0000099)2.45861930
64Spastic diplegia (HP:0001264)2.43671296
65Abnormal gallbladder morphology (HP:0012437)2.41616179
66Joint swelling (HP:0001386)2.38535969
67Cerebral edema (HP:0002181)2.37985142
68Cholelithiasis (HP:0001081)2.36786790
69Cholecystitis (HP:0001082)2.35513046
70Abnormal gallbladder physiology (HP:0012438)2.35513046
71Mitral stenosis (HP:0001718)2.35133872
72Cardiovascular calcification (HP:0011915)2.34949782
73Irritability (HP:0000737)2.34261162
74Amyloidosis (HP:0011034)2.30392144
75Epistaxis (HP:0000421)2.30377163
76Pigmentary retinal degeneration (HP:0001146)2.29124187
77Neonatal onset (HP:0003623)2.27571969
78Pancreatitis (HP:0001733)2.24507571
79Esophageal varix (HP:0002040)2.22065366
80Arthropathy (HP:0003040)2.21593345
81Gingival bleeding (HP:0000225)2.18039621
82Sensorimotor neuropathy (HP:0007141)2.16474416
83Proximal tubulopathy (HP:0000114)2.15605050
84Late onset (HP:0003584)2.15488839
85Generalized aminoaciduria (HP:0002909)2.14105206
86Enlarged kidneys (HP:0000105)2.10922504
87Vomiting (HP:0002013)2.10461776
88Menorrhagia (HP:0000132)2.09841491
89Pulmonary embolism (HP:0002204)2.08392680
90Brushfield spots (HP:0001088)2.07458350
91Abnormal tarsal ossification (HP:0008369)2.05336542
92Thrombophlebitis (HP:0004418)2.03595311
93Poikilocytosis (HP:0004447)2.03239330
94Opisthotonus (HP:0002179)2.02046514
95Hydroxyprolinuria (HP:0003080)2.01401637
96Abnormality of proline metabolism (HP:0010907)2.01401637
97Abnormality of the gallbladder (HP:0005264)1.98503182
98Rickets (HP:0002748)1.97943985
99Hyperinsulinemic hypoglycemia (HP:0000825)1.97311924
100Hemorrhage of the eye (HP:0011885)1.96646839
101Widely patent fontanelles and sutures (HP:0004492)1.95816019
102Alkalosis (HP:0001948)1.91770644
103Renal cortical cysts (HP:0000803)1.88078239
104Abnormal cartilage morphology (HP:0002763)1.87737186
105Abnormality of iron homeostasis (HP:0011031)1.87532629
106Abnormality of transition element cation homeostasis (HP:0011030)1.87331245
107Hypophosphatemic rickets (HP:0004912)1.85617191
108Abnormal enzyme/coenzyme activity (HP:0012379)1.84914308
109Hypothermia (HP:0002045)1.84794113
110Abnormality of carpal bone ossification (HP:0006257)1.84483941
111Flat acetabular roof (HP:0003180)1.83578388
112Elevated hepatic transaminases (HP:0002910)1.81978938
113Abnormality of vitamin metabolism (HP:0100508)1.80831748
114Glycosuria (HP:0003076)1.80476795
115Abnormality of urine glucose concentration (HP:0011016)1.80476795
116Nephritis (HP:0000123)1.79911922
117Generalized hypopigmentation of hair (HP:0011358)1.78920616
118Pancreatic islet-cell hyperplasia (HP:0004510)1.77835293
119Abnormality of the nasal septum (HP:0000419)1.71250041
120Hyperphosphaturia (HP:0003109)1.68117097
121Ileus (HP:0002595)1.59830381
122Cerebral palsy (HP:0100021)1.55501287
123Gangrene (HP:0100758)1.52872023
124Neoplasm of the liver (HP:0002896)1.52813144
125Increased mean platelet volume (HP:0011877)1.50630631
126Increased serum ferritin (HP:0003281)1.49713612
127Prolonged bleeding time (HP:0003010)1.49522269
128Broad alveolar ridges (HP:0000187)1.49212770
129Bifid scrotum (HP:0000048)1.48707403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.80585365
2ERN14.49795568
3FGFR44.39136214
4SIK14.24632486
5ACVR1B4.10702753
6INSRR3.03510187
7TAOK33.03267760
8ERBB42.88320516
9MST1R2.67846985
10WNK42.59585850
11PDK22.22196814
12MAP2K42.18513776
13PIK3CG1.91439815
14MAPK111.86749480
15STK391.86590453
16PKN21.81516044
17FRK1.78658525
18FLT31.73659218
19FER1.69426095
20TYK21.65275552
21LATS11.58666755
22BMPR1B1.54826201
23OXSR11.54459226
24PTK61.53534200
25TRIB31.43806326
26MAPKAPK31.38693768
27NEK91.38273088
28ABL21.37985244
29NLK1.35019901
30FGFR21.28769740
31GRK61.27160631
32MAP3K71.26678431
33DAPK21.24897023
34PRKAA21.24057494
35KDR1.21071665
36JAK21.19984218
37MAP2K31.18362836
38LMTK21.15579941
39MAP3K141.13299701
40BCR1.12307907
41TBK11.12179223
42FGFR11.08823529
43EPHB11.05599018
44PINK11.05318781
45MAP3K31.05132973
46MAPK41.04137200
47ERBB21.00382871
48JAK10.99835335
49TIE10.98635500
50ADRBK20.97323544
51MAPK150.95162271
52MET0.94635077
53IRAK30.93592776
54MAP4K20.89124144
55WNK30.87386498
56MAP3K100.86340254
57PRKCZ0.86178059
58EIF2AK30.84167280
59STK38L0.82402500
60CSK0.82271514
61EPHA30.81748363
62ICK0.81256207
63MAPK120.80640863
64MYLK0.79991054
65MAP2K60.79887653
66CAMK2G0.79594159
67MAP3K110.79530294
68BRSK20.78640588
69NTRK30.78281248
70CAMK1D0.77609203
71CAMKK20.76948503
72TGFBR20.76842295
73MATK0.75370382
74PRKG20.74673123
75PRKACG0.74249098
76GRK10.73232595
77TYRO30.71807337
78GSK3A0.71374087
79SGK30.70598367
80CASK0.70276646
81CDK60.69910730
82STK380.68895968
83WNK10.68379103
84IKBKE0.68363540
85TNK20.66313749
86MAP3K120.64775336
87DYRK1B0.63774691
88RPS6KB10.63540823
89PAK30.63481138
90PRKAA10.62930926
91RIPK10.62886480
92PRKG10.60472214
93FGFR30.59116619
94FGR0.57800996
95EPHA20.57723570
96CSF1R0.57691585
97MAPK70.56834485
98PTK20.55872578
99SGK10.55831099
100SGK20.54385574
101PRKCQ0.53025002
102PDPK10.52687204
103MST40.51903942
104PRKCE0.50180083
105PRKACA0.48730544
106CSNK1D0.47802436
107PIK3CA0.47705111
108IGF1R0.46796120
109TAOK20.45244879
110MAP3K50.43977530
111MAP2K10.43768657
112TEC0.43364440
113PKN10.43105645
114CSNK1G10.41127997
115TXK0.41006945
116MAP3K130.40128929
117SRC0.40005200
118CSNK1E0.39272015
119PRKACB0.37929527
120SGK4940.37791482
121SGK2230.37791482
122PRKCB0.37184591
123MELK0.36731035
124MAP3K10.36720801
125PDGFRA0.36211196
126MAP2K20.36195743
127STK30.35021748
128IRAK10.34068688
129RET0.33939837
130NUAK10.32954548
131CAMK40.32146431
132EGFR0.31199009
133MAP3K60.30691870
134PDK10.30465545
135PRKCG0.27911249
136PRKCA0.27345478
137CAMK1G0.27180719
138IRAK20.26744131
139MAP3K20.26610911
140ABL10.26500764
141PBK0.25827590
142ITK0.25335105
143EPHB20.25245268
144CDK40.25125431
145AKT30.24566442
146MTOR0.23859154
147EPHA40.23641981

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45634117
2Nitrogen metabolism_Homo sapiens_hsa009103.49445900
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35113328
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.34095264
5Arginine biosynthesis_Homo sapiens_hsa002203.04063943
6Tryptophan metabolism_Homo sapiens_hsa003802.71986221
7Complement and coagulation cascades_Homo sapiens_hsa046102.70648747
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63316833
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53894482
10Fatty acid degradation_Homo sapiens_hsa000712.49250706
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47568036
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38030709
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31578656
14* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11604245
15Butanoate metabolism_Homo sapiens_hsa006502.11341403
16Peroxisome_Homo sapiens_hsa041462.07358679
17Chemical carcinogenesis_Homo sapiens_hsa052041.98581746
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97474182
19Histidine metabolism_Homo sapiens_hsa003401.97279999
20Caffeine metabolism_Homo sapiens_hsa002321.93729191
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.91381654
22Propanoate metabolism_Homo sapiens_hsa006401.91357227
23PPAR signaling pathway_Homo sapiens_hsa033201.89171423
24Fatty acid metabolism_Homo sapiens_hsa012121.78643329
25beta-Alanine metabolism_Homo sapiens_hsa004101.74079746
26Staphylococcus aureus infection_Homo sapiens_hsa051501.73421706
27Retinol metabolism_Homo sapiens_hsa008301.73360581
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.72174144
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66330988
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65439330
31Phenylalanine metabolism_Homo sapiens_hsa003601.58195861
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55360799
33Bile secretion_Homo sapiens_hsa049761.51849130
34Selenocompound metabolism_Homo sapiens_hsa004501.50650580
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50527660
36Tyrosine metabolism_Homo sapiens_hsa003501.43668389
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43234142
38Sulfur metabolism_Homo sapiens_hsa009201.41083442
39Starch and sucrose metabolism_Homo sapiens_hsa005001.37395620
40Pyruvate metabolism_Homo sapiens_hsa006201.36465703
41Fatty acid elongation_Homo sapiens_hsa000621.32514578
42Fat digestion and absorption_Homo sapiens_hsa049751.29724212
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.27435102
44Folate biosynthesis_Homo sapiens_hsa007901.24551542
45ABC transporters_Homo sapiens_hsa020101.23408717
46Biosynthesis of amino acids_Homo sapiens_hsa012301.15840165
47Steroid biosynthesis_Homo sapiens_hsa001001.12347592
48Carbon metabolism_Homo sapiens_hsa012001.10270414
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08599517
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.05531688
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.01632864
52Vitamin digestion and absorption_Homo sapiens_hsa049770.99290355
53Arginine and proline metabolism_Homo sapiens_hsa003300.96778776
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95491941
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92155813
56Sulfur relay system_Homo sapiens_hsa041220.91186346
57Vitamin B6 metabolism_Homo sapiens_hsa007500.91060342
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87312247
59Lysine degradation_Homo sapiens_hsa003100.79415630
60Glutathione metabolism_Homo sapiens_hsa004800.75091224
61Glycerolipid metabolism_Homo sapiens_hsa005610.72206316
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70924501
63One carbon pool by folate_Homo sapiens_hsa006700.63457975
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59248328
65Pentose phosphate pathway_Homo sapiens_hsa000300.55238528
66Fatty acid biosynthesis_Homo sapiens_hsa000610.53223218
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49053349
68Metabolic pathways_Homo sapiens_hsa011000.46068678
69Sphingolipid metabolism_Homo sapiens_hsa006000.37504056
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36881998
71Prion diseases_Homo sapiens_hsa050200.35789390
72Other glycan degradation_Homo sapiens_hsa005110.33512634
73Galactose metabolism_Homo sapiens_hsa000520.32454209
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29672033
75Fructose and mannose metabolism_Homo sapiens_hsa000510.28326578
76Linoleic acid metabolism_Homo sapiens_hsa005910.25500456
77Insulin resistance_Homo sapiens_hsa049310.23525384
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.22102175
79N-Glycan biosynthesis_Homo sapiens_hsa005100.17858805
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.17306297
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13234268
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09426087
83Glucagon signaling pathway_Homo sapiens_hsa049220.08206595
84AMPK signaling pathway_Homo sapiens_hsa041520.01574377
85Circadian rhythm_Homo sapiens_hsa047100.00145443
86Pertussis_Homo sapiens_hsa05133-0.2246194
87Protein digestion and absorption_Homo sapiens_hsa04974-0.2178374
88Amoebiasis_Homo sapiens_hsa05146-0.2175188
89Ether lipid metabolism_Homo sapiens_hsa00565-0.2104155
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2029393
91Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1845992
92Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1783560
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1748796
94Mineral absorption_Homo sapiens_hsa04978-0.1671229
95Hepatitis C_Homo sapiens_hsa05160-0.1487970
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1443666
97Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1351935
98Regulation of autophagy_Homo sapiens_hsa04140-0.1318544
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1219494
100Pancreatic secretion_Homo sapiens_hsa04972-0.1207120
101Lysosome_Homo sapiens_hsa04142-0.1179843
102African trypanosomiasis_Homo sapiens_hsa05143-0.1172239
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1115297
104Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0848143
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0661454
106Renin-angiotensin system_Homo sapiens_hsa04614-0.0543429
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0398984
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0376982
109Platelet activation_Homo sapiens_hsa04611-0.0328896
110Serotonergic synapse_Homo sapiens_hsa04726-0.0135346

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »