FMO6P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.21390060
2motile cilium assembly (GO:0044458)7.99236366
3axoneme assembly (GO:0035082)7.81484110
4regulation of cilium movement (GO:0003352)7.17718535
5left/right axis specification (GO:0070986)5.62505235
6diterpenoid biosynthetic process (GO:0016102)4.77622368
7intraciliary transport (GO:0042073)4.73971483
8ventricular system development (GO:0021591)4.45293285
9left/right pattern formation (GO:0060972)4.44770665
10cilium organization (GO:0044782)4.40871779
11limb bud formation (GO:0060174)4.38096656
12microtubule bundle formation (GO:0001578)4.36408157
13cilium assembly (GO:0042384)4.29364499
14one-carbon compound transport (GO:0019755)4.20271323
15regulation of microtubule-based movement (GO:0060632)4.08235171
16primary alcohol catabolic process (GO:0034310)3.97846498
17retinoic acid metabolic process (GO:0042573)3.81574949
18cilium morphogenesis (GO:0060271)3.71477896
19response to pheromone (GO:0019236)3.71162867
20ethanol metabolic process (GO:0006067)3.69109584
21cellular component assembly involved in morphogenesis (GO:0010927)3.60056732
22negative regulation of T cell differentiation in thymus (GO:0033085)3.55600312
23cornea development in camera-type eye (GO:0061303)3.46811912
24regulation of germinal center formation (GO:0002634)3.37345141
25tachykinin receptor signaling pathway (GO:0007217)3.34715304
26neural tube formation (GO:0001841)3.31963062
27ethanol oxidation (GO:0006069)3.26187869
28glutathione derivative metabolic process (GO:1901685)3.23346775
29glutathione derivative biosynthetic process (GO:1901687)3.23346775
30response to xenobiotic stimulus (GO:0009410)3.19547011
31reverse cholesterol transport (GO:0043691)3.18697566
32high-density lipoprotein particle remodeling (GO:0034375)3.18559053
33regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.15187317
34microtubule-based movement (GO:0007018)3.11888292
35lung epithelium development (GO:0060428)3.11633426
36cell projection assembly (GO:0030031)3.11527867
37photoreceptor cell maintenance (GO:0045494)3.10184077
38cytoplasmic microtubule organization (GO:0031122)3.10124990
39lateral ventricle development (GO:0021670)3.07027072
40vitamin transmembrane transport (GO:0035461)3.04693896
41retinol metabolic process (GO:0042572)3.03242771
42phospholipid homeostasis (GO:0055091)3.01558048
43keratinocyte development (GO:0003334)2.99108677
44exogenous drug catabolic process (GO:0042738)2.95311228
45regulation of interleukin-5 production (GO:0032674)2.86503095
46phosphatidylcholine biosynthetic process (GO:0006656)2.84910285
47pharyngeal system development (GO:0060037)2.82937075
48terpenoid biosynthetic process (GO:0016114)2.80839427
49positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.79327219
50calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.78998572
51retinal cone cell development (GO:0046549)2.78857425
52determination of left/right symmetry (GO:0007368)2.76095334
53keratinization (GO:0031424)2.74351601
54glomerular epithelial cell development (GO:0072310)2.73680282
55sperm motility (GO:0030317)2.72842267
56phospholipid efflux (GO:0033700)2.72568268
57drug catabolic process (GO:0042737)2.71882040
58positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.69551564
59O-glycan processing (GO:0016266)2.68905953
60protein localization to cilium (GO:0061512)2.67842711
61determination of bilateral symmetry (GO:0009855)2.65632794
62specification of symmetry (GO:0009799)2.64674513
63regulation of collateral sprouting (GO:0048670)2.60376539
64UDP-N-acetylglucosamine metabolic process (GO:0006047)2.59300799
65primary alcohol metabolic process (GO:0034308)2.59189185
66regulation of cytokine secretion involved in immune response (GO:0002739)2.57238900
67lung lobe morphogenesis (GO:0060463)2.56996001
68negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.56736122
69positive regulation of smoothened signaling pathway (GO:0045880)2.56389543
70centriole assembly (GO:0098534)2.54739914
71progesterone metabolic process (GO:0042448)2.53630363
72metanephric mesenchyme development (GO:0072075)2.52974810
73oligosaccharide biosynthetic process (GO:0009312)2.52810654
74excretion (GO:0007588)2.51423278
75cellular ketone body metabolic process (GO:0046950)2.47281519
76positive regulation of digestive system process (GO:0060456)2.47264090
77androgen metabolic process (GO:0008209)2.46887424
78aldehyde catabolic process (GO:0046185)2.45904987
79smoothened signaling pathway (GO:0007224)2.44719092
80nucleoside diphosphate phosphorylation (GO:0006165)2.44685813
81regulation of hippo signaling (GO:0035330)2.44609076
82epithelial cell differentiation involved in kidney development (GO:0035850)2.44126169
83multicellular organism reproduction (GO:0032504)2.42809457
84magnesium ion transport (GO:0015693)2.42412666
85lateral sprouting from an epithelium (GO:0060601)2.41297535
86sperm capacitation (GO:0048240)2.38913426
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.37183542
88L-ascorbic acid metabolic process (GO:0019852)2.34019501
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.33221987
90establishment of planar polarity (GO:0001736)2.32862178
91establishment of tissue polarity (GO:0007164)2.32862178
92positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.32164149
93embryonic epithelial tube formation (GO:0001838)2.30905536
94transepithelial transport (GO:0070633)2.29605936
95negative regulation of lipase activity (GO:0060192)2.28436098
96somite development (GO:0061053)2.28398940
97cilium or flagellum-dependent cell motility (GO:0001539)13.3783081
98axonemal dynein complex assembly (GO:0070286)12.5778247
99cilium movement (GO:0003341)11.4465709
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.8678045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.01742795
2GBX2_23144817_ChIP-Seq_PC3_Human2.53340919
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28890428
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23426771
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20024719
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19073138
7PIAS1_25552417_ChIP-Seq_VCAP_Human2.16768395
8AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.16684472
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.13036695
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01449141
11NR3C1_21868756_ChIP-Seq_MCF10A_Human1.96823113
12FUS_26573619_Chip-Seq_HEK293_Human1.93195076
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88685829
14SMAD4_21799915_ChIP-Seq_A2780_Human1.86436913
15BCAT_22108803_ChIP-Seq_LS180_Human1.81943905
16TAF15_26573619_Chip-Seq_HEK293_Human1.76690768
17ZNF274_21170338_ChIP-Seq_K562_Hela1.76488434
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76411925
19STAT3_23295773_ChIP-Seq_U87_Human1.75695537
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75544178
21TP53_16413492_ChIP-PET_HCT116_Human1.73980329
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72653359
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.72517110
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69108471
25P300_19829295_ChIP-Seq_ESCs_Human1.68566002
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67579784
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66676742
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.62242971
29ER_23166858_ChIP-Seq_MCF-7_Human1.61580551
30TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59234990
31DROSHA_22980978_ChIP-Seq_HELA_Human1.57287569
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.56537489
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56205042
34CBP_20019798_ChIP-Seq_JUKART_Human1.56205042
35SMAD3_21741376_ChIP-Seq_HESCs_Human1.56184723
36TCF4_22108803_ChIP-Seq_LS180_Human1.54949530
37AHR_22903824_ChIP-Seq_MCF-7_Human1.54630235
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52949621
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52831672
40IGF1R_20145208_ChIP-Seq_DFB_Human1.51183610
41TCF4_23295773_ChIP-Seq_U87_Human1.50816262
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50773340
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50558796
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50329569
45TP53_18474530_ChIP-ChIP_U2OS_Human1.49912541
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.46984964
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.44285685
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42908865
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42077242
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41708915
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41708915
52EWS_26573619_Chip-Seq_HEK293_Human1.39944367
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39842510
54SOX2_19829295_ChIP-Seq_ESCs_Human1.37195718
55NANOG_19829295_ChIP-Seq_ESCs_Human1.37195718
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.36732790
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36692982
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.35780885
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35440387
60TP63_23658742_ChIP-Seq_EP156T_Human1.34674813
61RXR_22108803_ChIP-Seq_LS180_Human1.34424968
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34216977
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32582074
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32582074
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32259770
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31086026
67CDX2_22108803_ChIP-Seq_LS180_Human1.30600997
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30032319
69* AR_25329375_ChIP-Seq_VCAP_Human1.28723795
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.27490910
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27459215
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.27347414
73RUNX2_22187159_ChIP-Seq_PCA_Human1.26380092
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.26354235
75CJUN_26792858_Chip-Seq_BT549_Human1.25601549
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25363010
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25034753
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.24586291
79AR_21572438_ChIP-Seq_LNCaP_Human1.23522197
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23224549
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.21987363
82ETV1_20927104_ChIP-Seq_GIST48_Human1.20565720
83P53_22387025_ChIP-Seq_ESCs_Mouse1.19468451
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.18488344
85AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18433940
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15231724
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13779426
88P300_18555785_Chip-Seq_ESCs_Mouse1.13506105
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.13162215
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.12962318
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12685025
92TBL1_22424771_ChIP-Seq_293T_Human1.11844580
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.11483150
94SMAD4_21741376_ChIP-Seq_HESCs_Human1.11440048
95PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.11206342
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09567347
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09211332
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.08148221
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06707880
100TCF4_18268006_ChIP-ChIP_LS174T_Human1.05572857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.73524461
2MP0003950_abnormal_plasma_membrane3.42874377
3MP0002653_abnormal_ependyma_morphology3.41756537
4MP0010234_abnormal_vibrissa_follicle3.32217857
5MP0010678_abnormal_skin_adnexa2.91222709
6MP0001984_abnormal_olfaction2.85934777
7MP0008875_abnormal_xenobiotic_pharmacok2.83855463
8MP0003283_abnormal_digestive_organ2.79494572
9MP0000383_abnormal_hair_follicle2.68496474
10MP0004043_abnormal_pH_regulation2.47141456
11MP0002876_abnormal_thyroid_physiology2.40638254
12MP0002102_abnormal_ear_morphology2.28733452
13MP0002132_abnormal_respiratory_system2.24431864
14MP0005551_abnormal_eye_electrophysiolog2.23389353
15MP0005503_abnormal_tendon_morphology2.21733778
16MP0004019_abnormal_vitamin_homeostasis2.19452710
17MP0001986_abnormal_taste_sensitivity2.07608042
18MP0005275_abnormal_skin_tensile2.01739933
19MP0002282_abnormal_trachea_morphology1.90966144
20MP0005646_abnormal_pituitary_gland1.88154546
21MP0002168_other_aberrant_phenotype1.70192485
22MP0002277_abnormal_respiratory_mucosa1.59873841
23MP0002234_abnormal_pharynx_morphology1.58811861
24MP0003938_abnormal_ear_development1.58768016
25MP0005377_hearing/vestibular/ear_phenot1.57178479
26MP0003878_abnormal_ear_physiology1.57178479
27MP0005085_abnormal_gallbladder_physiolo1.55013752
28MP0003195_calcinosis1.54643463
29MP0005253_abnormal_eye_physiology1.54557592
30MP0005075_abnormal_melanosome_morpholog1.51737696
31MP0005310_abnormal_salivary_gland1.48970181
32MP0008789_abnormal_olfactory_epithelium1.43999507
33MP0003252_abnormal_bile_duct1.43853933
34MP0010329_abnormal_lipoprotein_level1.42478114
35MP0003941_abnormal_skin_development1.41986461
36MP0001485_abnormal_pinna_reflex1.40966946
37MP0002254_reproductive_system_inflammat1.39844903
38MP0010386_abnormal_urinary_bladder1.36518614
39MP0005670_abnormal_white_adipose1.36310366
40MP0004133_heterotaxia1.36250381
41MP0003191_abnormal_cellular_cholesterol1.35686239
42MP0000372_irregular_coat_pigmentation1.34835752
43MP0002160_abnormal_reproductive_system1.30825001
44MP0001501_abnormal_sleep_pattern1.29309815
45MP0002736_abnormal_nociception_after1.28027223
46MP0001346_abnormal_lacrimal_gland1.26855973
47MP0008004_abnormal_stomach_pH1.24152502
48MP0002909_abnormal_adrenal_gland1.22929967
49MP0008872_abnormal_physiological_respon1.21109330
50MP0000467_abnormal_esophagus_morphology1.20534521
51MP0001270_distended_abdomen1.13958516
52MP0003937_abnormal_limbs/digits/tail_de1.12779576
53MP0003045_fibrosis1.12503289
54MP0005645_abnormal_hypothalamus_physiol1.10681800
55MP0001529_abnormal_vocalization1.07183838
56MP0005084_abnormal_gallbladder_morpholo1.05136668
57MP0009046_muscle_twitch1.05064503
58MP0002108_abnormal_muscle_morphology1.05013926
59MP0002735_abnormal_chemical_nociception1.04972317
60MP0001756_abnormal_urination1.02938836
61MP0005395_other_phenotype1.02590256
62MP0002233_abnormal_nose_morphology0.99380137
63MP0005623_abnormal_meninges_morphology0.97425331
64MP0000678_abnormal_parathyroid_gland0.96691664
65MP0001324_abnormal_eye_pigmentation0.96556473
66MP0002638_abnormal_pupillary_reflex0.95881966
67MP0004883_abnormal_blood_vessel0.95830656
68MP0005365_abnormal_bile_salt0.93597207
69MP0005636_abnormal_mineral_homeostasis0.93532664
70MP0002127_abnormal_cardiovascular_syste0.90124345
71MP0005367_renal/urinary_system_phenotyp0.88691349
72MP0000516_abnormal_urinary_system0.88691349
73MP0010030_abnormal_orbit_morphology0.87646316
74MP0002272_abnormal_nervous_system0.86954945
75MP0000470_abnormal_stomach_morphology0.86210449
76MP0000613_abnormal_salivary_gland0.84830360
77MP0002136_abnormal_kidney_physiology0.83501602
78MP0005389_reproductive_system_phenotype0.83400308
79MP0001879_abnormal_lymphatic_vessel0.81576459
80MP0003943_abnormal_hepatobiliary_system0.81529772
81MP0001486_abnormal_startle_reflex0.79462484
82MP0002734_abnormal_mechanical_nocicepti0.78839619
83MP0000631_abnormal_neuroendocrine_gland0.78783591
84MP0000049_abnormal_middle_ear0.78180704
85MP0000427_abnormal_hair_cycle0.77242958
86MP0009053_abnormal_anal_canal0.76459344
87MP0001664_abnormal_digestion0.75560256
88MP0005164_abnormal_response_to0.74971922
89MP0004264_abnormal_extraembryonic_tissu0.74762429
90MP0008057_abnormal_DNA_replication0.74378628
91MP0005023_abnormal_wound_healing0.72911646
92MP0001764_abnormal_homeostasis0.72794232
93MP0009643_abnormal_urine_homeostasis0.72490761
94MP0000639_abnormal_adrenal_gland0.71317823
95MP0000681_abnormal_thyroid_gland0.70962740
96MP0001970_abnormal_pain_threshold0.70810773
97MP0003890_abnormal_embryonic-extraembry0.70459662
98MP0006276_abnormal_autonomic_nervous0.70165923
99MP0006082_CNS_inflammation0.69970845
100MP0001299_abnormal_eye_distance/0.67192056

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.88144329
2Abnormal ciliary motility (HP:0012262)9.41578494
3Absent/shortened dynein arms (HP:0200106)9.41439035
4Dynein arm defect of respiratory motile cilia (HP:0012255)9.41439035
5Abnormal respiratory motile cilium physiology (HP:0012261)9.16120066
6Abnormal respiratory motile cilium morphology (HP:0005938)8.92005887
7Abnormal respiratory epithelium morphology (HP:0012253)8.92005887
8Rhinitis (HP:0012384)8.36150503
9Chronic bronchitis (HP:0004469)6.32404603
10Bronchiectasis (HP:0002110)5.93254381
11Nasal polyposis (HP:0100582)4.44370630
12Pancreatic fibrosis (HP:0100732)4.16527025
13Chronic hepatic failure (HP:0100626)4.12780386
14True hermaphroditism (HP:0010459)4.03474402
15Pancreatic cysts (HP:0001737)3.83578147
16Abnormality of the nasal mucosa (HP:0000433)3.52203268
17Bronchitis (HP:0012387)3.42597059
18Molar tooth sign on MRI (HP:0002419)3.41173339
19Abnormality of midbrain morphology (HP:0002418)3.41173339
20Chronic sinusitis (HP:0011109)3.31907534
21Recurrent sinusitis (HP:0011108)3.24637307
22Occipital encephalocele (HP:0002085)3.24499652
23Cystic liver disease (HP:0006706)3.23958454
24Nephronophthisis (HP:0000090)3.19323202
25Infertility (HP:0000789)3.04831592
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.93175550
27Male infertility (HP:0003251)2.79875007
28Hyperactive renin-angiotensin system (HP:0000841)2.79582457
29Postaxial foot polydactyly (HP:0001830)2.78345569
30Abnormality of the renal medulla (HP:0100957)2.69487418
31Congenital hepatic fibrosis (HP:0002612)2.64186353
32Recurrent otitis media (HP:0000403)2.61310340
33Abnormality of macular pigmentation (HP:0008002)2.48865171
34Chronic otitis media (HP:0000389)2.38413163
35Medial flaring of the eyebrow (HP:0010747)2.36336422
36Anencephaly (HP:0002323)2.27525112
37Bell-shaped thorax (HP:0001591)2.24671412
38Decreased circulating renin level (HP:0003351)2.17848539
39Decreased central vision (HP:0007663)2.16889221
40Furrowed tongue (HP:0000221)2.16223806
41Male pseudohermaphroditism (HP:0000037)2.15155686
42Tubulointerstitial nephritis (HP:0001970)2.14138770
43Sclerocornea (HP:0000647)2.13579022
44Hypoplastic labia majora (HP:0000059)2.11533279
45Lip pit (HP:0100267)2.02180167
46Congenital primary aphakia (HP:0007707)2.00711976
47Postaxial hand polydactyly (HP:0001162)1.98597442
48Gait imbalance (HP:0002141)1.96082994
49Tubular atrophy (HP:0000092)1.94821313
50Abnormality of the renal cortex (HP:0011035)1.89951732
51Abnormality of the labia majora (HP:0012881)1.89730166
52Genital tract atresia (HP:0001827)1.87247237
53Vaginal atresia (HP:0000148)1.87117677
54Asplenia (HP:0001746)1.87099927
55Hyperkalemia (HP:0002153)1.86526661
56Abnormal drinking behavior (HP:0030082)1.85033857
57Polydipsia (HP:0001959)1.85033857
58Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85015739
59Oculomotor apraxia (HP:0000657)1.83491728
60Aplasia/Hypoplasia of the spleen (HP:0010451)1.79091801
61Nephrogenic diabetes insipidus (HP:0009806)1.74929414
62Preaxial hand polydactyly (HP:0001177)1.72253783
63Glucose intolerance (HP:0000833)1.68134246
64Renal salt wasting (HP:0000127)1.66808526
65Popliteal pterygium (HP:0009756)1.66058557
66Tubulointerstitial abnormality (HP:0001969)1.65963652
67Intrahepatic cholestasis (HP:0001406)1.65926532
68Nephropathy (HP:0000112)1.62421744
69Thyroid-stimulating hormone excess (HP:0002925)1.61729386
70Median cleft lip (HP:0000161)1.58099416
71Hyperaldosteronism (HP:0000859)1.57820391
72Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.56358992
73Chorioretinal atrophy (HP:0000533)1.52812864
74Long clavicles (HP:0000890)1.51349271
75Abnormal rod and cone electroretinograms (HP:0008323)1.51165370
76Alacrima (HP:0000522)1.50743036
77Labial hypoplasia (HP:0000066)1.50335433
78Disproportionate short-trunk short stature (HP:0003521)1.48829604
79Spontaneous abortion (HP:0005268)1.48635312
80Abnormality of renin-angiotensin system (HP:0000847)1.48109855
81Dyschromatopsia (HP:0007641)1.48073696
82Hyperventilation (HP:0002883)1.45936749
83Narrow forehead (HP:0000341)1.45904843
84Widely spaced teeth (HP:0000687)1.45211771
85Tubulointerstitial fibrosis (HP:0005576)1.44311697
86Hypokalemic alkalosis (HP:0001949)1.44273091
87Poor coordination (HP:0002370)1.43496176
88Recurrent bronchitis (HP:0002837)1.43354373
89Short thorax (HP:0010306)1.42943061
90Posterior subcapsular cataract (HP:0007787)1.42501379
91Hypomagnesemia (HP:0002917)1.42029908
92Cupped ear (HP:0000378)1.39983219
93Hepatoblastoma (HP:0002884)1.39011737
94Intestinal atresia (HP:0011100)1.38628468
95Bifid tongue (HP:0010297)1.37551783
96Stage 5 chronic kidney disease (HP:0003774)1.36139816
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.35752212
98Anophthalmia (HP:0000528)1.35664143
99Decreased lacrimation (HP:0000633)1.34241042
100Bony spicule pigmentary retinopathy (HP:0007737)1.32954273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.20943314
2MST44.67085451
3MAPK154.35847620
4MAP4K23.78603407
5PDK23.56421282
6NEK13.10753159
7STK242.63499198
8PINK12.26785821
9MAP3K42.02321812
10STK391.99063222
11WNK31.92615698
12BCR1.74635147
13MAP3K21.70243780
14NUAK11.68640591
15LATS11.62978589
16TAOK31.55858456
17MAPK131.54924491
18BCKDK1.53899224
19GRK11.51620041
20NEK61.50742143
21EPHA21.42094432
22ACVR1B1.40050169
23ADRBK21.34597628
24MAPKAPK31.33871400
25BMPR1B1.33132713
26AKT31.30773641
27TXK1.28251138
28MAP3K31.21813679
29MAP3K121.19731986
30BRSK21.16640443
31PAK31.13132909
32NLK1.13105652
33PTK2B1.12808747
34FER1.12024383
35OXSR11.08449226
36INSRR1.06059400
37ERBB31.01895395
38STK160.96180996
39PRKCE0.91422636
40PBK0.88458031
41GRK60.85066255
42STK38L0.83685394
43PIK3CA0.83349493
44NME10.81988408
45TRPM70.81044670
46WNK40.79068680
47NEK20.78394626
48TRIM280.75567686
49TGFBR10.73722902
50CSNK1G20.72766090
51CASK0.70986778
52SGK20.70481998
53ILK0.70155185
54STK30.70032843
55MARK10.68289443
56MKNK20.66787727
57PRKCQ0.65412107
58CSNK1A1L0.63247166
59MYLK0.58782345
60CSNK1G10.56226746
61TYK20.52127344
62PLK40.51589807
63KSR10.50205158
64ADRBK10.49800471
65SGK30.49397592
66TEC0.48888473
67PRKAA20.44407677
68MATK0.44402874
69PRKCI0.43352291
70CCNB10.42873384
71BRD40.40431405
72LMTK20.40369286
73ERBB20.39987524
74EIF2AK30.39187298
75CAMK2A0.38623128
76CSNK1D0.38568574
77MAP3K70.38506003
78CAMK1G0.38225580
79PRKACA0.38225150
80PLK20.37955064
81ZAK0.36917476
82MAPKAPK50.36214550
83ABL10.33168591
84EGFR0.32383132
85PRKACB0.31840016
86DDR20.30997300
87IGF1R0.30672036
88PRKG10.30065577
89PRKCA0.29980985
90CSNK1G30.29337005
91OBSCN0.27804204
92PRKCG0.27444830
93PIK3CG0.27174132
94MAP2K10.26200970
95ROCK10.25831155
96PRKCB0.25505258
97SGK2230.24326353
98SGK4940.24326353
99CSNK1A10.23722912
100DYRK1A0.23674497

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.04535858
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.85373458
3Chemical carcinogenesis_Homo sapiens_hsa052043.46812234
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.91753816
5Nitrogen metabolism_Homo sapiens_hsa009102.59726956
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.51245497
7Retinol metabolism_Homo sapiens_hsa008302.49590280
8Caffeine metabolism_Homo sapiens_hsa002322.47737597
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36545867
10Linoleic acid metabolism_Homo sapiens_hsa005912.34258434
11Histidine metabolism_Homo sapiens_hsa003402.25808097
12Propanoate metabolism_Homo sapiens_hsa006402.05932241
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99388530
14ABC transporters_Homo sapiens_hsa020101.99182261
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95792497
16Glutathione metabolism_Homo sapiens_hsa004801.87519922
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84761811
18Tyrosine metabolism_Homo sapiens_hsa003501.83380690
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77965179
20Sphingolipid metabolism_Homo sapiens_hsa006001.75589278
21beta-Alanine metabolism_Homo sapiens_hsa004101.75228071
22Salivary secretion_Homo sapiens_hsa049701.68292656
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67849723
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63874743
25Phenylalanine metabolism_Homo sapiens_hsa003601.53837762
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53269433
27Phototransduction_Homo sapiens_hsa047441.49169932
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47096363
29Butanoate metabolism_Homo sapiens_hsa006501.45509679
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40582582
31Arachidonic acid metabolism_Homo sapiens_hsa005901.29179935
32Peroxisome_Homo sapiens_hsa041461.24535303
33Tight junction_Homo sapiens_hsa045301.24420864
34Huntingtons disease_Homo sapiens_hsa050161.24193460
35Taste transduction_Homo sapiens_hsa047421.23952891
36Fatty acid degradation_Homo sapiens_hsa000711.21810240
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19539261
38PPAR signaling pathway_Homo sapiens_hsa033201.16237806
39Nicotine addiction_Homo sapiens_hsa050331.12057319
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10512529
41Fat digestion and absorption_Homo sapiens_hsa049751.03014864
42Tryptophan metabolism_Homo sapiens_hsa003800.98549561
43Ether lipid metabolism_Homo sapiens_hsa005650.96321811
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93237362
45Circadian rhythm_Homo sapiens_hsa047100.92686560
46Starch and sucrose metabolism_Homo sapiens_hsa005000.90378445
47Hedgehog signaling pathway_Homo sapiens_hsa043400.88800992
48Serotonergic synapse_Homo sapiens_hsa047260.88104377
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84009025
50Complement and coagulation cascades_Homo sapiens_hsa046100.83368915
51Vitamin digestion and absorption_Homo sapiens_hsa049770.81224073
52Glycerolipid metabolism_Homo sapiens_hsa005610.75648631
53Olfactory transduction_Homo sapiens_hsa047400.71822249
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.71046202
55Fatty acid biosynthesis_Homo sapiens_hsa000610.68902059
56Arginine biosynthesis_Homo sapiens_hsa002200.68015221
57Dorso-ventral axis formation_Homo sapiens_hsa043200.67926157
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.67757110
59Glycerophospholipid metabolism_Homo sapiens_hsa005640.67382723
60Basal cell carcinoma_Homo sapiens_hsa052170.62305401
61African trypanosomiasis_Homo sapiens_hsa051430.59894068
62Calcium signaling pathway_Homo sapiens_hsa040200.58700327
63TGF-beta signaling pathway_Homo sapiens_hsa043500.54240654
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53694762
65Hippo signaling pathway_Homo sapiens_hsa043900.50377086
66Fatty acid metabolism_Homo sapiens_hsa012120.50135910
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49557477
68Mineral absorption_Homo sapiens_hsa049780.47597166
69Metabolic pathways_Homo sapiens_hsa011000.45276692
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45142870
71Purine metabolism_Homo sapiens_hsa002300.45072866
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43290360
73Hepatitis C_Homo sapiens_hsa051600.40739626
74Pancreatic secretion_Homo sapiens_hsa049720.36134081
75Cocaine addiction_Homo sapiens_hsa050300.33934205
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32172558
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29976032
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.27701852
79Morphine addiction_Homo sapiens_hsa050320.27178422
80RNA polymerase_Homo sapiens_hsa030200.26847942
81Long-term depression_Homo sapiens_hsa047300.26683693
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26652026
83Circadian entrainment_Homo sapiens_hsa047130.26306992
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25913006
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.24207606
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23739720
87Basal transcription factors_Homo sapiens_hsa030220.23371436
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22397577
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22330411
90Selenocompound metabolism_Homo sapiens_hsa004500.22189541
91Glutamatergic synapse_Homo sapiens_hsa047240.22066637
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21924319
93Fatty acid elongation_Homo sapiens_hsa000620.20098402
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19696969
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19455804
96Choline metabolism in cancer_Homo sapiens_hsa052310.19289152
97cAMP signaling pathway_Homo sapiens_hsa040240.18412962
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.18348570
99ECM-receptor interaction_Homo sapiens_hsa045120.18334178
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.17673750

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