FMOD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* keratan sulfate catabolic process (GO:0042340)8.98022227
2protein heterotrimerization (GO:0070208)8.25920248
3collagen fibril organization (GO:0030199)7.91816664
4cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.33152097
5chondrocyte development (GO:0002063)5.88300014
6bone trabecula formation (GO:0060346)5.70978288
7myoblast migration (GO:0051451)5.49356218
8extracellular matrix assembly (GO:0085029)5.38830711
9collagen metabolic process (GO:0032963)5.18243245
10peptidyl-proline hydroxylation (GO:0019511)5.12316737
11collagen catabolic process (GO:0030574)5.11555627
12multicellular organismal macromolecule metabolic process (GO:0044259)4.97825998
13skin morphogenesis (GO:0043589)4.97684070
14cell migration involved in heart development (GO:0060973)4.90100363
15multicellular organismal catabolic process (GO:0044243)4.81646556
16endothelial cell morphogenesis (GO:0001886)4.72411780
17multicellular organismal metabolic process (GO:0044236)4.69800831
18skeletal muscle adaptation (GO:0043501)4.60677108
19glomerular filtration (GO:0003094)4.42479520
20epithelial cell-cell adhesion (GO:0090136)4.38340588
21chondrocyte proliferation (GO:0035988)4.34501986
22extracellular fibril organization (GO:0043206)4.29158272
23protein hydroxylation (GO:0018126)4.27330855
24cartilage condensation (GO:0001502)4.19237676
25cell aggregation (GO:0098743)4.19237676
26endodermal cell differentiation (GO:0035987)4.18932704
27positive regulation of chondrocyte differentiation (GO:0032332)4.16561005
28muscle cell migration (GO:0014812)4.12165870
29positive regulation of cartilage development (GO:0061036)4.12164236
30extracellular matrix disassembly (GO:0022617)4.11898454
31sequestering of extracellular ligand from receptor (GO:0035581)4.01278808
32renal filtration (GO:0097205)4.00592599
33regulation of skeletal muscle contraction (GO:0014819)3.96941094
34* keratan sulfate biosynthetic process (GO:0018146)3.95185963
35dermatan sulfate biosynthetic process (GO:0030208)3.86853165
36peripheral nervous system axon ensheathment (GO:0032292)3.85933328
37myelination in peripheral nervous system (GO:0022011)3.85933328
38fibril organization (GO:0097435)3.85930554
39muscle filament sliding (GO:0030049)3.66111221
40actin-myosin filament sliding (GO:0033275)3.66111221
41barbed-end actin filament capping (GO:0051016)3.64716003
42regulation of plasminogen activation (GO:0010755)3.60827120
43endochondral ossification (GO:0001958)3.60593025
44replacement ossification (GO:0036075)3.60593025
45* extracellular matrix organization (GO:0030198)3.58447455
46* extracellular structure organization (GO:0043062)3.57039228
47low-density lipoprotein particle clearance (GO:0034383)3.55707694
48negative regulation of cartilage development (GO:0061037)3.55510343
49dermatan sulfate metabolic process (GO:0030205)3.53590824
50cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.53490638
51regulation of cartilage development (GO:0061035)3.51794666
52vascular endothelial growth factor signaling pathway (GO:0038084)3.51773888
53negative regulation of heart growth (GO:0061117)3.43208326
54negative regulation of cardiac muscle tissue growth (GO:0055022)3.43208326
55* keratan sulfate metabolic process (GO:0042339)3.42764623
56positive regulation of extracellular matrix organization (GO:1903055)3.40712656
57detection of molecule of bacterial origin (GO:0032490)3.39664817
58regulation of chondrocyte differentiation (GO:0032330)3.37542738
59complement activation, classical pathway (GO:0006958)3.29598790
60regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.28939966
61negative regulation of Rho protein signal transduction (GO:0035024)3.26837221
62negative regulation of stress fiber assembly (GO:0051497)3.24957698
63triglyceride catabolic process (GO:0019433)3.21978616
64non-canonical Wnt signaling pathway (GO:0035567)3.21637101
65negative regulation of chondrocyte differentiation (GO:0032331)3.21415326
66endocrine hormone secretion (GO:0060986)3.20948445
67actin-mediated cell contraction (GO:0070252)3.20946239
68ovulation from ovarian follicle (GO:0001542)3.18182534
69type B pancreatic cell proliferation (GO:0044342)3.16081286
70cornea development in camera-type eye (GO:0061303)3.15668609
71negative regulation of smooth muscle cell migration (GO:0014912)3.15549054
72* sulfur compound catabolic process (GO:0044273)3.15063587
73chondroitin sulfate biosynthetic process (GO:0030206)3.13436338
74protein retention in ER lumen (GO:0006621)3.12435355
75adhesion of symbiont to host (GO:0044406)3.10865302
76protein trimerization (GO:0070206)3.09674431
77response to BMP (GO:0071772)3.07603096
78cellular response to BMP stimulus (GO:0071773)3.07603096
79regulation of transforming growth factor beta2 production (GO:0032909)3.05904134
80* glycosaminoglycan biosynthetic process (GO:0006024)3.05680456
81* glycosaminoglycan catabolic process (GO:0006027)3.05138043
82ossification (GO:0001503)3.04952591
83cell proliferation involved in metanephros development (GO:0072203)3.03542588
84atrioventricular valve morphogenesis (GO:0003181)3.03176188
85cell adhesion mediated by integrin (GO:0033627)3.03052196
86maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02165605
87metanephric mesenchyme development (GO:0072075)3.02155750
88tooth mineralization (GO:0034505)3.00983249
89peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.00857236
90* aminoglycan biosynthetic process (GO:0006023)3.00452752
91iron ion import (GO:0097286)2.99149436
92chondrocyte differentiation (GO:0002062)2.99049413
93basement membrane organization (GO:0071711)2.98939787
94cartilage development (GO:0051216)2.98659847
95cellular response to vitamin (GO:0071295)2.97918182
96positive regulation of receptor recycling (GO:0001921)2.96756232
97negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.96352003
98regulation of extracellular matrix disassembly (GO:0010715)2.92650206
99glomerular basement membrane development (GO:0032836)2.91573071
100complement activation (GO:0006956)2.91298513
101response to gravity (GO:0009629)2.91207928
102skeletal system development (GO:0001501)2.90435447
103neuron projection extension involved in neuron projection guidance (GO:1902284)2.87852554
104axon extension involved in axon guidance (GO:0048846)2.87852554
105adhesion of symbiont to host cell (GO:0044650)2.85961644
106virion attachment to host cell (GO:0019062)2.85961644
107acylglycerol catabolic process (GO:0046464)2.84826950
108neutral lipid catabolic process (GO:0046461)2.84826950
109endothelium development (GO:0003158)2.81989799
110* aminoglycan catabolic process (GO:0006026)2.80998766
111smooth muscle tissue development (GO:0048745)2.76408892
112negative regulation of interleukin-8 production (GO:0032717)2.76262947
113regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.75789009
114retina vasculature morphogenesis in camera-type eye (GO:0061299)2.73764629
115regulation of integrin-mediated signaling pathway (GO:2001044)2.71721697
116angiogenesis involved in wound healing (GO:0060055)2.71024080
117positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.69739930
118proteoglycan metabolic process (GO:0006029)2.69445242
119camera-type eye morphogenesis (GO:0048593)2.69230855
120transcytosis (GO:0045056)2.67795527
121cellular response to amino acid stimulus (GO:0071230)2.66460511
122cellular response to vitamin D (GO:0071305)2.65504102
123bone development (GO:0060348)2.65406828
124kidney mesenchyme development (GO:0072074)2.65218845
125apoptotic cell clearance (GO:0043277)2.62834927
126negative regulation of complement activation (GO:0045916)2.61566563
127blood vessel maturation (GO:0001955)2.61533772
128positive regulation of endothelial cell apoptotic process (GO:2000353)2.61319295
129negative regulation of fatty acid transport (GO:2000192)2.60668216
130venous blood vessel morphogenesis (GO:0048845)2.60183369
131negative regulation of granulocyte differentiation (GO:0030853)2.57890825
132craniofacial suture morphogenesis (GO:0097094)2.57495345
133positive regulation of cellular amide metabolic process (GO:0034250)2.56218725
134cell proliferation involved in kidney development (GO:0072111)2.56068589
135stress fiber assembly (GO:0043149)2.51954999
136negative regulation of homotypic cell-cell adhesion (GO:0034111)2.51671589
137chondroitin sulfate catabolic process (GO:0030207)2.50917198
138negative regulation of smooth muscle cell proliferation (GO:0048662)2.50290005
139protein localization to cell surface (GO:0034394)2.50121585
140negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.48645289
141cGMP-mediated signaling (GO:0019934)2.47333018
142surfactant homeostasis (GO:0043129)2.44774179
143positive regulation of pseudopodium assembly (GO:0031274)2.40416355
144endothelial cell chemotaxis (GO:0035767)2.40046428
145negative regulation of platelet activation (GO:0010544)2.37712888
146response to fluid shear stress (GO:0034405)2.36288116
147cellular response to epinephrine stimulus (GO:0071872)2.33541004
148regulation of membrane protein ectodomain proteolysis (GO:0051043)2.31170933
149regulation of sequestering of triglyceride (GO:0010889)2.29779554
150positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.29697432
151regulation of glucose import in response to insulin stimulus (GO:2001273)2.28996473
152positive regulation of cholesterol efflux (GO:0010875)2.27765641
153regulation of pseudopodium assembly (GO:0031272)2.27474731
154cell differentiation involved in metanephros development (GO:0072202)2.26190098
155protein activation cascade (GO:0072376)2.26167710
156vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.25932734
157positive regulation of vasculogenesis (GO:2001214)2.24872448
158positive regulation of fat cell differentiation (GO:0045600)2.23511144
159negative regulation of BMP signaling pathway (GO:0030514)2.22644563
160phagocytosis, recognition (GO:0006910)2.22114857
161response to dietary excess (GO:0002021)2.21911583

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.42382851
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.51065238
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.40340061
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.77973791
5TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.70947557
6* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.62559517
7AR_21572438_ChIP-Seq_LNCaP_Human2.57683196
8CLOCK_20551151_ChIP-Seq_293T_Human2.47874742
9* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.28222013
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26841801
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26841801
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23907246
13CJUN_26792858_Chip-Seq_BT549_Human2.22197502
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.19380933
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17560620
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.16220667
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.13870234
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08018054
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07977393
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03462603
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97659641
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95538230
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93471144
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.92458296
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92451702
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.89568672
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.89070266
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78454116
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.75259942
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71891281
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.68535704
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67029945
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.59596327
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.57662605
35EGR1_19032775_ChIP-ChIP_M12_Human1.55012119
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53476555
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52503639
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52503639
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50759735
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.50486400
41EZH2_22144423_ChIP-Seq_EOC_Human1.47938017
42BRD4_25478319_ChIP-Seq_HGPS_Human1.46245361
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45264865
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.45259756
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44784756
46* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.42927906
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.42226810
48DROSHA_22980978_ChIP-Seq_HELA_Human1.38316413
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35366604
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33686176
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.32545889
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28975418
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.28820120
54TBX20_22080862_ChIP-Seq_HEART_Mouse1.28258221
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.28258221
56KDM2B_26808549_Chip-Seq_K562_Human1.28029926
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27842702
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27629124
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.27482656
60PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.25969820
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25829393
62SMC3_22415368_ChIP-Seq_MEFs_Mouse1.25133815
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25050983
64TP53_18474530_ChIP-ChIP_U2OS_Human1.24994338
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24316067
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21968268
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.20788405
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.19361635
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18604123
70LXR_22292898_ChIP-Seq_THP-1_Human1.17005269
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16713019
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15612945
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14003941
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13304320
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11797502
76* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11760795
77RXR_22108803_ChIP-Seq_LS180_Human1.10125108
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10044801
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09628838
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08320022
81SA1_22415368_ChIP-Seq_MEFs_Mouse1.08089460
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08036506
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06626528
84P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06392074
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06387631
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05793898
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05555632
88* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05354086
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04162727
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.03731445
91UBF1/2_26484160_Chip-Seq_HMECs_Human1.02629752
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02260783
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01174707
94SOX2_20726797_ChIP-Seq_SW620_Human1.00156628
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99904523
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97384518
97ISL1_27105846_Chip-Seq_CPCs_Mouse0.96751376
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96607712
99RACK7_27058665_Chip-Seq_MCF-7_Human0.96580395
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94902163
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93206615
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92881715
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92718700
104BP1_19119308_ChIP-ChIP_Hs578T_Human0.92094164
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91888197
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91340202
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90992625
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90359728
109TP53_23651856_ChIP-Seq_MEFs_Mouse0.90158360
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89050771
111PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88872561
112CTCF_27219007_Chip-Seq_Bcells_Human0.87868967
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87670189
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.87244870
115KDM2B_26808549_Chip-Seq_DND41_Human0.87043992
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86739524
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86672343
118* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86414307
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86378410
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86195600
121* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86150043
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84643711
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83560614
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.83463508
125GATA1_22025678_ChIP-Seq_K562_Human0.83101051
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83041853
127AHR_22903824_ChIP-Seq_MCF-7_Human0.81751854
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81549369
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80367945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.03339333
2* MP0005503_abnormal_tendon_morphology7.83297105
3* MP0005275_abnormal_skin_tensile4.98755547
4MP0005257_abnormal_intraocular_pressure4.70311546
5MP0003705_abnormal_hypodermis_morpholog3.29992147
6MP0000751_myopathy3.24307688
7MP0003279_aneurysm3.17671194
8MP0005670_abnormal_white_adipose2.99373709
9* MP0002108_abnormal_muscle_morphology2.80566248
10MP0004134_abnormal_chest_morphology2.73019934
11MP0001958_emphysema2.71369462
12* MP0005508_abnormal_skeleton_morphology2.64541924
13MP0003646_muscle_fatigue2.37715372
14MP0006054_spinal_hemorrhage2.35044670
15MP0009250_abnormal_appendicular_skeleto2.34087354
16MP0010368_abnormal_lymphatic_system2.30946629
17MP0004272_abnormal_basement_membrane2.26816055
18MP0009384_cardiac_valve_regurgitation2.22042836
19* MP0002933_joint_inflammation2.21929027
20MP0001542_abnormal_bone_strength2.10027346
21MP0002282_abnormal_trachea_morphology1.97096111
22MP0003011_delayed_dark_adaptation1.96201123
23* MP0000163_abnormal_cartilage_morphology1.95273093
24MP0002896_abnormal_bone_mineralization1.82008027
25MP0005666_abnormal_adipose_tissue1.81087505
26* MP0002115_abnormal_skeleton_extremities1.80450570
27* MP0005390_skeleton_phenotype1.77578907
28MP0002060_abnormal_skin_morphology1.77198453
29MP0002295_abnormal_pulmonary_circulatio1.70444654
30MP0004145_abnormal_muscle_electrophysio1.70061958
31MP0003283_abnormal_digestive_organ1.65480961
32MP0001879_abnormal_lymphatic_vessel1.60286755
33MP0006138_congestive_heart_failure1.54694151
34MP0002932_abnormal_joint_morphology1.51709459
35MP0000749_muscle_degeneration1.46989062
36MP0002113_abnormal_skeleton_development1.45834750
37* MP0005369_muscle_phenotype1.45199471
38MP0001533_abnormal_skeleton_physiology1.39608526
39MP0002971_abnormal_brown_adipose1.36169655
40MP0001299_abnormal_eye_distance/1.35283393
41MP0001243_abnormal_dermal_layer1.31339462
42MP0000759_abnormal_skeletal_muscle1.30760141
43MP0005023_abnormal_wound_healing1.29310191
44MP0003828_pulmonary_edema1.28999322
45MP0004130_abnormal_muscle_cell1.28863532
46MP0009115_abnormal_fat_cell1.20039869
47MP0002998_abnormal_bone_remodeling1.18922757
48MP0002106_abnormal_muscle_physiology1.18695515
49MP0003566_abnormal_cell_adhesion1.17345485
50MP0000750_abnormal_muscle_regeneration1.15183280
51MP0000733_abnormal_muscle_development1.14583214
52MP0000013_abnormal_adipose_tissue1.14028855
53* MP0002109_abnormal_limb_morphology1.13703471
54MP0003385_abnormal_body_wall1.11606781
55MP0000249_abnormal_blood_vessel1.09203844
56MP0009780_abnormal_chondrocyte_physiolo1.07932453
57MP0002837_dystrophic_cardiac_calcinosis1.07762474
58MP0005623_abnormal_meninges_morphology1.07502471
59MP0004036_abnormal_muscle_relaxation1.06800262
60MP0010030_abnormal_orbit_morphology1.03837824
61MP0008004_abnormal_stomach_pH1.03425789
62MP0000762_abnormal_tongue_morphology0.99898822
63MP0002876_abnormal_thyroid_physiology0.99246811
64MP0002089_abnormal_postnatal_growth/wei0.99058797
65MP0003191_abnormal_cellular_cholesterol0.98195889
66MP0003795_abnormal_bone_structure0.97394870
67MP0001270_distended_abdomen0.96399498
68* MP0004087_abnormal_muscle_fiber0.95594239
69MP0005058_abnormal_lysosome_morphology0.94167926
70MP0000428_abnormal_craniofacial_morphol0.93609164
71MP0004185_abnormal_adipocyte_glucose0.91017213
72MP0001544_abnormal_cardiovascular_syste0.88491064
73MP0005385_cardiovascular_system_phenoty0.88491064
74MP0009840_abnormal_foam_cell0.86849272
75* MP0000747_muscle_weakness0.86080542
76MP0003937_abnormal_limbs/digits/tail_de0.85698317
77MP0001661_extended_life_span0.85457146
78MP0002249_abnormal_larynx_morphology0.85244431
79MP0002254_reproductive_system_inflammat0.84794144
80MP0003329_amyloid_beta_deposits0.84784761
81MP0003755_abnormal_palate_morphology0.82657231
82MP0010329_abnormal_lipoprotein_level0.81723985
83MP0002116_abnormal_craniofacial_bone0.81173038
84MP0003942_abnormal_urinary_system0.80988079
85MP0003091_abnormal_cell_migration0.79649824
86MP0000049_abnormal_middle_ear0.79257064
87MP0003959_abnormal_lean_body0.78269737
88MP0002114_abnormal_axial_skeleton0.78194376
89MP0002127_abnormal_cardiovascular_syste0.77525087
90MP0002970_abnormal_white_adipose0.77461875
91MP0005167_abnormal_blood-brain_barrier0.77272148
92MP0002233_abnormal_nose_morphology0.76714853
93MP0005076_abnormal_cell_differentiation0.76484923
94MP0000462_abnormal_digestive_system0.76069629
95MP0005165_increased_susceptibility_to0.75938478
96MP0000534_abnormal_ureter_morphology0.75345254
97MP0004883_abnormal_blood_vessel0.74704271
98MP0005620_abnormal_muscle_contractility0.74443798
99MP0003115_abnormal_respiratory_system0.73238662
100MP0000767_abnormal_smooth_muscle0.72803491
101MP0000604_amyloidosis0.72378939
102MP0003950_abnormal_plasma_membrane0.69904944
103MP0002111_abnormal_tail_morphology0.69690720
104MP0000343_altered_response_to0.69445486
105MP0000432_abnormal_head_morphology0.67799781
106MP0005409_darkened_coat_color0.65417340
107MP0004019_abnormal_vitamin_homeostasis0.64986623
108MP0008775_abnormal_heart_ventricle0.64064925
109MP0005330_cardiomyopathy0.63776480
110MP0002269_muscular_atrophy0.62618983
111MP0000230_abnormal_systemic_arterial0.62085190
112MP0002972_abnormal_cardiac_muscle0.61825331
113MP0000003_abnormal_adipose_tissue0.61281447
114MP0009053_abnormal_anal_canal0.60993566
115MP0001348_abnormal_lacrimal_gland0.60563404
116MP0004858_abnormal_nervous_system0.60218061
117MP0005197_abnormal_uvea_morphology0.60151068
118MP0002166_altered_tumor_susceptibility0.59727102
119MP0002796_impaired_skin_barrier0.59202094
120MP0003724_increased_susceptibility_to0.58224690
121MP0000681_abnormal_thyroid_gland0.57404979
122MP0003045_fibrosis0.56291760
123MP0001175_abnormal_lung_morphology0.56094201
124MP0002168_other_aberrant_phenotype0.55828093
125MP0010352_gastrointestinal_tract_polyps0.55574983
126MP0005334_abnormal_fat_pad0.54122377
127MP0003935_abnormal_craniofacial_develop0.52908934
128MP0005164_abnormal_response_to0.51889500
129MP0005595_abnormal_vascular_smooth0.51832731
130MP0003075_altered_response_to0.51430489
131MP0005388_respiratory_system_phenotype0.51181259
132MP0002133_abnormal_respiratory_system0.51181259
133* MP0002128_abnormal_blood_circulation0.51053254
134MP0005375_adipose_tissue_phenotype0.48957413
135MP0001177_atelectasis0.48887136
136MP0004084_abnormal_cardiac_muscle0.48295406
137MP0009672_abnormal_birth_weight0.44810957
138MP0003448_altered_tumor_morphology0.44500674
139* MP0001614_abnormal_blood_vessel0.43949768
140MP0001915_intracranial_hemorrhage0.42298944

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.43658830
2Premature rupture of membranes (HP:0001788)5.68335326
3Type 1 muscle fiber predominance (HP:0003803)4.86489172
4Mesomelia (HP:0003027)4.72178451
5Systemic lupus erythematosus (HP:0002725)4.39211261
6Epiphyseal dysplasia (HP:0002656)4.36559199
7Neonatal short-limb short stature (HP:0008921)4.17062505
8Vascular tortuosity (HP:0004948)4.15587707
9Ankle contracture (HP:0006466)4.10377407
10Complement deficiency (HP:0004431)4.06341740
11Small epiphyses (HP:0010585)3.92949659
12Abnormality of complement system (HP:0005339)3.80260540
13Hypoplastic ischia (HP:0003175)3.79347549
14Deformed tarsal bones (HP:0008119)3.79199964
15Follicular hyperkeratosis (HP:0007502)3.69700418
16Slender build (HP:0001533)3.65238318
17Ulnar deviation of the wrist (HP:0003049)3.63599985
18Soft skin (HP:0000977)3.61428775
19Mild short stature (HP:0003502)3.52887870
20Broad metatarsal (HP:0001783)3.51058616
21Increased connective tissue (HP:0009025)3.48512271
22Abnormality of the phalanges of the 2nd finger (HP:0009541)3.41019049
23Irregular epiphyses (HP:0010582)3.38675029
24Aortic dissection (HP:0002647)3.35981778
25Abnormality of the ischium (HP:0003174)3.34265635
26Genu recurvatum (HP:0002816)3.32420929
27Round ear (HP:0100830)3.30582224
28Peritonitis (HP:0002586)3.28591756
29Spinal rigidity (HP:0003306)3.25127480
30Osteoarthritis (HP:0002758)3.23525875
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.22303228
32Abnormality of dentin (HP:0010299)3.20395820
33Arterial tortuosity (HP:0005116)3.20361029
34Pulmonary artery stenosis (HP:0004415)3.19449314
35Shallow orbits (HP:0000586)3.17198341
36Vertebral compression fractures (HP:0002953)3.15535177
37Joint stiffness (HP:0001387)3.12160435
38Biconcave vertebral bodies (HP:0004586)3.01385247
39Atrophic scars (HP:0001075)2.97813457
40Abnormality of the middle phalanges of the toes (HP:0010183)2.95782998
41Abnormality of the proximal phalanges of the hand (HP:0009834)2.94703154
42Radial bowing (HP:0002986)2.91664226
43Wormian bones (HP:0002645)2.90105131
44Increased variability in muscle fiber diameter (HP:0003557)2.88626179
45Bladder diverticulum (HP:0000015)2.87490911
46Cervical subluxation (HP:0003308)2.86870941
47Short 1st metacarpal (HP:0010034)2.82108637
48Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.82108637
49Emphysema (HP:0002097)2.80957853
50Fibular hypoplasia (HP:0003038)2.78862291
51Glomerulonephritis (HP:0000099)2.77405308
52Aneurysm (HP:0002617)2.76730375
53Abnormality of skeletal muscle fiber size (HP:0012084)2.75382932
54Fibular aplasia (HP:0002990)2.75345511
55Wrist flexion contracture (HP:0001239)2.74035582
56Flat capital femoral epiphysis (HP:0003370)2.69263734
57Blue sclerae (HP:0000592)2.68827027
58Mildly elevated creatine phosphokinase (HP:0008180)2.68709978
59Cupped ribs (HP:0000887)2.67926946
60Muscle fiber splitting (HP:0003555)2.64404146
61Oligomenorrhea (HP:0000876)2.64378999
62Enlarged epiphyses (HP:0010580)2.58369285
63Mitral valve prolapse (HP:0001634)2.56764650
64Aortic valve stenosis (HP:0001650)2.56290053
65Overgrowth (HP:0001548)2.54962164
66Delayed epiphyseal ossification (HP:0002663)2.54794337
67Humeroradial synostosis (HP:0003041)2.54565147
68Synostosis involving the elbow (HP:0003938)2.54565147
69Coxa vara (HP:0002812)2.54389674
70Abnormality of the 1st metacarpal (HP:0010009)2.53296252
71Beaking of vertebral bodies (HP:0004568)2.52159295
72Abnormality of the 2nd finger (HP:0004100)2.49418892
73Nephritis (HP:0000123)2.48751546
74Spondylolisthesis (HP:0003302)2.47493393
75Osteolytic defects of the hand bones (HP:0009699)2.46503153
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.46503153
77Rhizomelia (HP:0008905)2.45636753
78Dilatation of the ascending aorta (HP:0005111)2.45295866
79Broad ribs (HP:0000885)2.43092338
80Abnormality of the acetabulum (HP:0003170)2.42342563
81Striae distensae (HP:0001065)2.42242112
82Fragile skin (HP:0001030)2.40957555
83Short hallux (HP:0010109)2.40150646
84Spinal cord compression (HP:0002176)2.39957059
85Breech presentation (HP:0001623)2.38685638
86Lumbar hyperlordosis (HP:0002938)2.37340434
87Acanthosis nigricans (HP:0000956)2.37283767
88Tarsal synostosis (HP:0008368)2.36976475
89Obstructive sleep apnea (HP:0002870)2.35826496
90Platyspondyly (HP:0000926)2.32720443
91Bowed forearm bones (HP:0003956)2.32360802
92Bowing of the arm (HP:0006488)2.32360802
93Hyperextensible skin (HP:0000974)2.32274138
94Cerebral aneurysm (HP:0004944)2.31798668
95Joint laxity (HP:0001388)2.31327462
96Aortic regurgitation (HP:0001659)2.31061637
97Limited hip movement (HP:0008800)2.29211510
98Femoral bowing (HP:0002980)2.28543904
99Exercise-induced muscle cramps (HP:0003710)2.27611874
100Bell-shaped thorax (HP:0001591)2.26645798
101Aortic aneurysm (HP:0004942)2.26353839
102Wide anterior fontanel (HP:0000260)2.25078903
103Narrow nasal bridge (HP:0000446)2.21928195
104Abnormal delivery (HP:0001787)2.21810688
105Calcaneovalgus deformity (HP:0001848)2.21018903
106Genu varum (HP:0002970)2.20829224
107Ovoid vertebral bodies (HP:0003300)2.20442161
108Ectopia lentis (HP:0001083)2.19131074
109Aplasia/Hypoplasia of the hallux (HP:0008362)2.18957613
110Aplasia/Hypoplasia of the fibula (HP:0006492)2.14613778
111Mitral regurgitation (HP:0001653)2.14475092
112Bowel diverticulosis (HP:0005222)2.14093694
113Flat cornea (HP:0007720)2.13890559
114Vitreoretinal degeneration (HP:0000655)2.13453124
115Venous abnormality (HP:0002624)2.13438281
116Persistence of primary teeth (HP:0006335)2.12727337
117Synostosis of carpal bones (HP:0005048)2.12490010
118Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.12297134
119Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.12168898
120Absent phalangeal crease (HP:0006109)2.12028220
121Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.11641582
122Abnormality of femoral epiphyses (HP:0006499)2.11641582
123Synostosis involving bones of the lower limbs (HP:0009138)2.10900384
124Synostosis involving bones of the feet (HP:0009140)2.10900384
125Metaphyseal cupping (HP:0003021)2.08201928
126Venous insufficiency (HP:0005293)2.07616906
127Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.04647113
128Polycythemia (HP:0001901)1.97661416
129Hypoplasia of the iris (HP:0007676)1.97238793
130Lymphangioma (HP:0100764)1.96516754
131Rectal prolapse (HP:0002035)1.94410757
132Mitral stenosis (HP:0001718)1.94031011
133Infantile muscular hypotonia (HP:0008947)1.90832612
134Hypoplasia of the odontoid process (HP:0003311)1.87071202
135Thin bony cortex (HP:0002753)1.85661084
136Camptodactyly of toe (HP:0001836)1.84328193
137Asymmetric septal hypertrophy (HP:0001670)1.83713964
138Patent foramen ovale (HP:0001655)1.83114718
139Flared iliac wings (HP:0002869)1.78268289
140Hypertriglyceridemia (HP:0002155)1.76262893
141Amyloidosis (HP:0011034)1.75765463
142Bronchomalacia (HP:0002780)1.75233494
143Turricephaly (HP:0000262)1.70844278
144Spontaneous hematomas (HP:0007420)1.69808396
145Bone cyst (HP:0012062)1.69277204
146Inguinal hernia (HP:0000023)1.67980409
147Dysostosis multiplex (HP:0000943)1.66781180
148Joint contractures involving the joints of the feet (HP:0100492)1.66600312
149Flexion contracture of toe (HP:0005830)1.66600312
150Delayed cranial suture closure (HP:0000270)1.64707538
151Gastrointestinal stroma tumor (HP:0100723)1.64243916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.68002872
2TRIB33.83215235
3ERN13.57457452
4TTN3.37830131
5SIK13.24554843
6LATS23.04527420
7PHKG12.83293537
8PHKG22.83293537
9EPHA32.61017603
10LATS12.55941265
11PDGFRA2.38526088
12TIE12.24521731
13PKN22.19124757
14RIPK12.14369314
15MAP3K32.11177148
16KIT1.88499147
17TESK11.80514352
18EPHB21.57823052
19MAP3K61.54669783
20PIK3CA1.53497417
21EPHB11.52006262
22OBSCN1.49892167
23NME11.47228482
24DMPK1.34871139
25MAPKAPK31.30204069
26TYK21.28293736
27NLK1.24157613
28TGFBR21.23357786
29ADRBK11.18922828
30GRK51.17947543
31PIK3CG1.13142196
32PAK21.11435784
33EEF2K1.08562431
34PRKD31.08177346
35NTRK11.07867457
36GRK11.07780295
37PRPF4B1.04855409
38MARK21.03573828
39ROCK11.02749506
40ABL21.02594563
41TAOK11.02470687
42FER1.02073734
43MAP3K131.01034798
44FGFR10.98482714
45PTK2B0.96528251
46NEK90.96205185
47BLK0.95856276
48MAP2K30.93385150
49PRKCH0.92583592
50STK38L0.91794973
51TBK10.91482729
52STK30.89672938
53LRRK20.88774284
54BMX0.88688813
55HIPK20.88269221
56PLK20.88061506
57MAP3K70.87689815
58PTK20.87671596
59MAPK120.87555754
60PTK60.87447968
61FGFR20.85228131
62PAK30.83986874
63MET0.83973389
64ERBB30.83190074
65PDGFRB0.82947170
66TGFBR10.81723486
67JAK10.74208790
68ZAP700.73232446
69ARAF0.72577311
70CAMK10.71334404
71ROCK20.69200867
72DAPK30.68484985
73PIM20.67582882
74GSK3A0.67243274
75STK380.65905301
76STK240.63654686
77RPS6KA20.63057370
78RET0.62397904
79TRPM70.62187700
80FGFR40.61894867
81PAK40.60161642
82FLT30.59923916
83PDPK10.59711006
84CSK0.58204423
85FGFR30.58097211
86PDK20.58034207
87PRKG20.57060964
88PRKD20.56873796
89AKT30.56348801
90JAK30.55405432
91MAP2K10.55340688
92MTOR0.54155622
93CAMKK10.53272659
94ILK0.51498290
95MAPK70.48760309
96PRKD10.48520018
97LMTK20.45399229
98PAK60.45135581
99MAPK30.43084329
100RPS6KL10.41137400
101RPS6KC10.41137400
102MAPK150.40247051
103MOS0.38905644
104INSR0.37527232
105WNK10.37010340
106KSR20.36943144
107PDK30.36718616
108PDK40.36718616
109MYLK0.36596629
110SRC0.34475492
111PRKAA10.33461724
112ICK0.32527339
113MAP2K20.32434447
114PRKACG0.32256410
115CLK10.31785799
116MAPKAPK50.31778665
117JAK20.30797391
118MST1R0.30284443
119MAPK40.27958958
120NEK10.26596828
121CAMKK20.26207888
122CAMK1G0.25991091
123CAMK2G0.25909882
124GRK70.24814973
125CAMK1D0.24809961
126MAPK10.22492060
127UHMK10.21605090
128PRKAA20.20967600
129CDK60.20916484
130LIMK10.20885537
131NTRK30.20485751
132ERBB40.19768342
133CDC42BPA0.19656763
134MAP3K10.19483124
135TAOK20.19429421
136PRKG10.19269983
137IGF1R0.18946532
138SGK10.18217748

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045126.07028232
2Protein digestion and absorption_Homo sapiens_hsa049743.98219887
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.72728986
4Malaria_Homo sapiens_hsa051443.57023050
5Focal adhesion_Homo sapiens_hsa045103.31780382
6Staphylococcus aureus infection_Homo sapiens_hsa051502.62278356
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.22980097
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.19643324
9PPAR signaling pathway_Homo sapiens_hsa033202.15234662
10TGF-beta signaling pathway_Homo sapiens_hsa043502.14274545
11Dilated cardiomyopathy_Homo sapiens_hsa054142.13646487
12Amoebiasis_Homo sapiens_hsa051461.79262608
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78369633
14PI3K-Akt signaling pathway_Homo sapiens_hsa041511.77636877
15Proteoglycans in cancer_Homo sapiens_hsa052051.65652606
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.60233578
17Other glycan degradation_Homo sapiens_hsa005111.56395356
18Complement and coagulation cascades_Homo sapiens_hsa046101.50241676
19Basal cell carcinoma_Homo sapiens_hsa052171.44244053
20Hippo signaling pathway_Homo sapiens_hsa043901.42530584
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42514737
22Starch and sucrose metabolism_Homo sapiens_hsa005001.36377712
23Phenylalanine metabolism_Homo sapiens_hsa003601.31049076
24Asthma_Homo sapiens_hsa053101.29309418
25Pertussis_Homo sapiens_hsa051331.29236560
26Histidine metabolism_Homo sapiens_hsa003401.28393074
27Hedgehog signaling pathway_Homo sapiens_hsa043401.27074172
28Insulin resistance_Homo sapiens_hsa049311.23916316
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19396633
30Prion diseases_Homo sapiens_hsa050201.18352552
31Adherens junction_Homo sapiens_hsa045201.17024465
32Fat digestion and absorption_Homo sapiens_hsa049751.14963354
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14007841
34Autoimmune thyroid disease_Homo sapiens_hsa053201.10400904
35Notch signaling pathway_Homo sapiens_hsa043301.09423907
36Glycerolipid metabolism_Homo sapiens_hsa005611.07745272
37Phagosome_Homo sapiens_hsa041451.06861609
38Bladder cancer_Homo sapiens_hsa052191.06155067
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05184850
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03984702
41Arachidonic acid metabolism_Homo sapiens_hsa005901.03269741
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01599458
43Phospholipase D signaling pathway_Homo sapiens_hsa040720.99038744
44Wnt signaling pathway_Homo sapiens_hsa043100.98320444
45Allograft rejection_Homo sapiens_hsa053300.96048393
46Tyrosine metabolism_Homo sapiens_hsa003500.95967831
47Melanogenesis_Homo sapiens_hsa049160.95883047
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.94571957
49Platelet activation_Homo sapiens_hsa046110.86736136
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.86023569
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85779906
52Graft-versus-host disease_Homo sapiens_hsa053320.84530782
53Arginine and proline metabolism_Homo sapiens_hsa003300.84472679
54Oxytocin signaling pathway_Homo sapiens_hsa049210.83366523
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83217173
56MicroRNAs in cancer_Homo sapiens_hsa052060.82830053
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.82024052
58Estrogen signaling pathway_Homo sapiens_hsa049150.79768738
59Fatty acid degradation_Homo sapiens_hsa000710.79324198
60Glucagon signaling pathway_Homo sapiens_hsa049220.77242677
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76915422
62Leishmaniasis_Homo sapiens_hsa051400.76849642
63Lysosome_Homo sapiens_hsa041420.74352795
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72498324
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.72354164
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72020242
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70933875
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70391598
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70067027
70Thyroid hormone synthesis_Homo sapiens_hsa049180.69492275
71Small cell lung cancer_Homo sapiens_hsa052220.68287200
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68189317
73Insulin signaling pathway_Homo sapiens_hsa049100.68043088
74Viral myocarditis_Homo sapiens_hsa054160.66505501
75HIF-1 signaling pathway_Homo sapiens_hsa040660.66285052
76GnRH signaling pathway_Homo sapiens_hsa049120.65638302
77Nitrogen metabolism_Homo sapiens_hsa009100.65436303
78Axon guidance_Homo sapiens_hsa043600.65368372
79Glioma_Homo sapiens_hsa052140.64877728
80Melanoma_Homo sapiens_hsa052180.64527528
81ABC transporters_Homo sapiens_hsa020100.64373886
82Calcium signaling pathway_Homo sapiens_hsa040200.63903678
83Acute myeloid leukemia_Homo sapiens_hsa052210.62756722
84Chronic myeloid leukemia_Homo sapiens_hsa052200.60293795
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.60249844
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59707370
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58296583
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58095773
89Gastric acid secretion_Homo sapiens_hsa049710.57841988
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57520683
91Galactose metabolism_Homo sapiens_hsa000520.56732631
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56201301
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55651768
94Ras signaling pathway_Homo sapiens_hsa040140.54947906
95Pathways in cancer_Homo sapiens_hsa052000.54195710
96TNF signaling pathway_Homo sapiens_hsa046680.54152252
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53377604
98Gap junction_Homo sapiens_hsa045400.51742404
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51251396
100Rap1 signaling pathway_Homo sapiens_hsa040150.51082870
101Vitamin digestion and absorption_Homo sapiens_hsa049770.50992327
102AMPK signaling pathway_Homo sapiens_hsa041520.50956420
103Retinol metabolism_Homo sapiens_hsa008300.50947587
104Mineral absorption_Homo sapiens_hsa049780.50821759
105Tight junction_Homo sapiens_hsa045300.49712951
106Tryptophan metabolism_Homo sapiens_hsa003800.49658319
107Toxoplasmosis_Homo sapiens_hsa051450.48978149
108Rheumatoid arthritis_Homo sapiens_hsa053230.48927391
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48421649
110Prostate cancer_Homo sapiens_hsa052150.48331595
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48071897
112Type I diabetes mellitus_Homo sapiens_hsa049400.47943515
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47671461
114Cocaine addiction_Homo sapiens_hsa050300.47588422
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.47544443
116Circadian rhythm_Homo sapiens_hsa047100.46634095
117MAPK signaling pathway_Homo sapiens_hsa040100.46031981
118Renin-angiotensin system_Homo sapiens_hsa046140.45618434
119Bile secretion_Homo sapiens_hsa049760.44674982
120Glutathione metabolism_Homo sapiens_hsa004800.44442195
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.44407099
122HTLV-I infection_Homo sapiens_hsa051660.44141197
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43780807
124Dorso-ventral axis formation_Homo sapiens_hsa043200.43736559
125Hematopoietic cell lineage_Homo sapiens_hsa046400.43657984
126Lysine degradation_Homo sapiens_hsa003100.42779769
127Renal cell carcinoma_Homo sapiens_hsa052110.42595251
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40811919
129Type II diabetes mellitus_Homo sapiens_hsa049300.38643818
130Ovarian steroidogenesis_Homo sapiens_hsa049130.38583525
131Insulin secretion_Homo sapiens_hsa049110.38198317
132Osteoclast differentiation_Homo sapiens_hsa043800.38073476
133cAMP signaling pathway_Homo sapiens_hsa040240.37648579
134Cholinergic synapse_Homo sapiens_hsa047250.36192293
135Pancreatic cancer_Homo sapiens_hsa052120.36060224
136Renin secretion_Homo sapiens_hsa049240.34499527
137FoxO signaling pathway_Homo sapiens_hsa040680.34341782
138Amphetamine addiction_Homo sapiens_hsa050310.33746455
139VEGF signaling pathway_Homo sapiens_hsa043700.33417035
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.33339148
141Olfactory transduction_Homo sapiens_hsa047400.32892988
142mTOR signaling pathway_Homo sapiens_hsa041500.32771407
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32035839
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30306657

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