FMR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)6.69327364
2nuclear pore organization (GO:0006999)5.46413042
3nuclear pore complex assembly (GO:0051292)5.44783101
4mitotic sister chromatid cohesion (GO:0007064)5.20422941
5protein localization to kinetochore (GO:0034501)4.89765515
6synapsis (GO:0007129)4.61127482
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.58668925
8regulation of nucleobase-containing compound transport (GO:0032239)4.08470274
9DNA unwinding involved in DNA replication (GO:0006268)3.96923624
10protein localization to chromosome, centromeric region (GO:0071459)3.90814337
11regulation of RNA export from nucleus (GO:0046831)3.86154289
12monoubiquitinated protein deubiquitination (GO:0035520)3.82951460
13chromatin assembly (GO:0031497)3.82387393
14protein heterotrimerization (GO:0070208)3.81578388
15pore complex assembly (GO:0046931)3.79561059
16alternative mRNA splicing, via spliceosome (GO:0000380)3.72781850
17epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.66630477
18mitotic chromosome condensation (GO:0007076)3.64677745
19histone H3-K9 demethylation (GO:0033169)3.62475692
20sister chromatid segregation (GO:0000819)3.57469607
21dorsal/ventral axis specification (GO:0009950)3.56315431
22genitalia morphogenesis (GO:0035112)3.50495650
23white fat cell differentiation (GO:0050872)3.46897857
24chromosome organization involved in meiosis (GO:0070192)3.45430155
25DNA topological change (GO:0006265)3.38882822
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37868747
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37868747
28positive regulation of mitotic sister chromatid separation (GO:1901970)3.37868747
29regulation of sister chromatid cohesion (GO:0007063)3.34022790
30response to UV-C (GO:0010225)3.33078405
31regulation of meiosis I (GO:0060631)3.32335443
32mitotic nuclear envelope disassembly (GO:0007077)3.30552387
33low-density lipoprotein particle clearance (GO:0034383)3.29855992
34regulation of histone H3-K9 methylation (GO:0051570)3.29623414
35embryonic retina morphogenesis in camera-type eye (GO:0060059)3.29490035
36pre-miRNA processing (GO:0031054)3.29012880
37nuclear envelope disassembly (GO:0051081)3.28569331
38membrane disassembly (GO:0030397)3.28569331
39DNA replication-dependent nucleosome assembly (GO:0006335)3.26796994
40DNA replication-dependent nucleosome organization (GO:0034723)3.26796994
41kinetochore organization (GO:0051383)3.25484981
42glucocorticoid receptor signaling pathway (GO:0042921)3.22583819
43otic vesicle formation (GO:0030916)3.21541730
44DNA synthesis involved in DNA repair (GO:0000731)3.16858900
45histone H3-K36 demethylation (GO:0070544)3.13824564
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13404238
47insulin-like growth factor receptor signaling pathway (GO:0048009)3.08613411
48anterior/posterior axis specification, embryo (GO:0008595)3.07688260
49regulation of DNA endoreduplication (GO:0032875)3.06554103
50positive regulation of chromosome segregation (GO:0051984)3.06263320
51DNA geometric change (GO:0032392)3.05802253
52NLS-bearing protein import into nucleus (GO:0006607)3.02968607
53DNA duplex unwinding (GO:0032508)3.01899652
54neuron remodeling (GO:0016322)3.00912163
55negative regulation of DNA repair (GO:0045738)3.00721619
56negative regulation of histone methylation (GO:0031061)2.98885964
57labyrinthine layer development (GO:0060711)2.95105061
58regulation of centriole replication (GO:0046599)2.94647184
59positive regulation of protein autophosphorylation (GO:0031954)2.93351725
60mitotic sister chromatid segregation (GO:0000070)2.92517237
61attachment of spindle microtubules to kinetochore (GO:0008608)2.92006848
62hippo signaling (GO:0035329)2.91914592
63cellular response to zinc ion (GO:0071294)2.91495819
64dosage compensation (GO:0007549)2.91202129
65protein localization to chromosome (GO:0034502)2.91049070
66regulation of Rac protein signal transduction (GO:0035020)2.91014071
67mitotic cytokinesis (GO:0000281)2.90635124
68cytoplasmic mRNA processing body assembly (GO:0033962)2.90596553
69collagen fibril organization (GO:0030199)2.84667211
70negative regulation of chondrocyte differentiation (GO:0032331)2.83510717
71meiotic chromosome segregation (GO:0045132)2.82152922
72sulfation (GO:0051923)2.80826604
73negative regulation of neurotransmitter secretion (GO:0046929)2.79886874
74negative regulation of phagocytosis (GO:0050765)2.78412538
75interkinetic nuclear migration (GO:0022027)2.74631700
76chromatin assembly or disassembly (GO:0006333)2.73769944
77male meiosis I (GO:0007141)2.73739891
78spindle assembly involved in mitosis (GO:0090307)2.73372963
79mRNA stabilization (GO:0048255)2.72092820
80RNA stabilization (GO:0043489)2.72092820
81IMP biosynthetic process (GO:0006188)2.70591821
82cell proliferation in forebrain (GO:0021846)2.70459972
83iron ion import (GO:0097286)2.69832144
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.69523207
85regulation of mitotic spindle organization (GO:0060236)2.69320557
86positive regulation of cAMP-mediated signaling (GO:0043950)2.68873378
87negative regulation of fatty acid transport (GO:2000192)2.68856449
88positive regulation of cellular response to insulin stimulus (GO:1900078)2.68496466
89growth hormone receptor signaling pathway (GO:0060396)2.67596665
90triglyceride catabolic process (GO:0019433)2.65933651
91regulation of transforming growth factor beta2 production (GO:0032909)2.65143613
92negative regulation of cartilage development (GO:0061037)2.64589159
93sister chromatid cohesion (GO:0007062)2.61533128
94spindle checkpoint (GO:0031577)2.61213741
95positive regulation of cardiac muscle hypertrophy (GO:0010613)2.60549466
96positive regulation of muscle hypertrophy (GO:0014742)2.60549466
97histone-serine phosphorylation (GO:0035404)2.60194587
98microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.58966579
99phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.58811415
100regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.58666904
101histone lysine demethylation (GO:0070076)2.56640570
102cytoskeleton-dependent cytokinesis (GO:0061640)2.54444999
103regulation of spindle organization (GO:0090224)2.54046627
104positive regulation of gluconeogenesis (GO:0045722)2.53839835
105negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.53713440
106corticosteroid receptor signaling pathway (GO:0031958)2.52175682
107negative regulation of hormone biosynthetic process (GO:0032353)2.52030326
108negative regulation of cardiac muscle tissue development (GO:0055026)2.51552329
109regulation of double-strand break repair (GO:2000779)2.50584977
110nuclear envelope organization (GO:0006998)2.50191544
111gastrulation with mouth forming second (GO:0001702)2.50124120
112peptidyl-proline hydroxylation (GO:0019511)2.48440688
113limb bud formation (GO:0060174)2.48344309
114negative regulation of translation, ncRNA-mediated (GO:0040033)2.48332553
115regulation of translation, ncRNA-mediated (GO:0045974)2.48332553
116negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48332553
117DNA conformation change (GO:0071103)2.48160172
118embryonic process involved in female pregnancy (GO:0060136)2.47276917
119negative regulation of fibrinolysis (GO:0051918)2.47198576
120regulation of helicase activity (GO:0051095)2.46350325
121regulation of centrosome cycle (GO:0046605)2.46281970
122spindle assembly (GO:0051225)2.45388152
123positive regulation of insulin receptor signaling pathway (GO:0046628)2.43901135
124negative regulation of mRNA processing (GO:0050686)2.43711498
125protein export from nucleus (GO:0006611)2.43363669
126piRNA metabolic process (GO:0034587)2.42872153
127chromosome condensation (GO:0030261)2.41708836
128regulation of centrosome duplication (GO:0010824)2.41678002
129histone demethylation (GO:0016577)2.40804651
130regulation of protein polyubiquitination (GO:1902914)2.40663570
131paraxial mesoderm development (GO:0048339)2.40480612
132protein K11-linked deubiquitination (GO:0035871)2.39941207
133regulation of chromosome segregation (GO:0051983)2.39579347
134translesion synthesis (GO:0019985)2.39561969
135positive regulation of fatty acid beta-oxidation (GO:0032000)2.39496772
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.39116764
137histone phosphorylation (GO:0016572)2.38960072
138positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38338828
139mitotic spindle checkpoint (GO:0071174)2.37495993
140early endosome to late endosome transport (GO:0045022)2.37045707
141regulation of DNA damage checkpoint (GO:2000001)2.36964313
142negative regulation of RNA splicing (GO:0033119)2.36383157
143ncRNA 3-end processing (GO:0043628)2.36334128
144regulation of fibrinolysis (GO:0051917)2.36327386
145cerebellar Purkinje cell differentiation (GO:0021702)2.35549911
146negative regulation of granulocyte differentiation (GO:0030853)2.35070529
147DNA methylation involved in gamete generation (GO:0043046)2.35028576
148negative regulation of dendrite morphogenesis (GO:0050774)2.32804605
149embryonic hindlimb morphogenesis (GO:0035116)2.32026554
150regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.31855791
151peptidyl-threonine phosphorylation (GO:0018107)2.31229385
152synaptonemal complex assembly (GO:0007130)2.29948514
153positive regulation of meiosis (GO:0045836)2.28314393
154anterior/posterior axis specification (GO:0009948)2.27623236
155intestinal epithelial cell development (GO:0060576)2.27333569
156embryonic foregut morphogenesis (GO:0048617)2.26051630
157synaptonemal complex organization (GO:0070193)2.25944745
158regulation of bile acid biosynthetic process (GO:0070857)2.25929862
159organ induction (GO:0001759)2.23580565
160positive regulation of cardiac muscle cell differentiation (GO:2000727)2.22718224
161flavonoid metabolic process (GO:0009812)2.22176229
162regulation of collateral sprouting (GO:0048670)2.22148689
163negative regulation of organ growth (GO:0046621)2.21794791
164metaphase plate congression (GO:0051310)2.20881653
165regulation of DNA-dependent DNA replication (GO:0090329)2.20409053
166developmental induction (GO:0031128)2.20328977
167meiotic nuclear division (GO:0007126)2.19549615
168meiotic cell cycle process (GO:1903046)2.19467139
169negative regulation of systemic arterial blood pressure (GO:0003085)2.19459690
170microtubule anchoring (GO:0034453)2.18658787
171positive regulation of glycoprotein biosynthetic process (GO:0010560)2.18023234
172negative regulation of astrocyte differentiation (GO:0048712)2.17725425
173forebrain morphogenesis (GO:0048853)2.16447855
174protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.15852482
175mRNA modification (GO:0016556)2.15154884
176regulation of establishment of cell polarity (GO:2000114)2.13650373
177negative regulation of hormone metabolic process (GO:0032351)2.13586823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.07725564
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.87255028
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.14796853
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.84292990
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65226165
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.02931730
7AR_21909140_ChIP-Seq_LNCAP_Human2.96526896
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74737385
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51263319
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30486245
11TAF15_26573619_Chip-Seq_HEK293_Human2.15116028
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.14224909
13CLOCK_20551151_ChIP-Seq_293T_Human2.12933338
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06037575
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05491859
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.00722171
17E2F7_22180533_ChIP-Seq_HELA_Human10.7342492
18GBX2_23144817_ChIP-Seq_PC3_Human1.99955809
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97690701
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97302840
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96633687
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93869440
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92255812
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91437482
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88212900
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.86992276
27* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86071007
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.83741235
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79575937
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.79271291
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.79271291
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.79271291
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73759494
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69210126
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.66310119
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65781280
37P300_19829295_ChIP-Seq_ESCs_Human1.65486210
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64465408
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63892401
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.60606463
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58209503
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57969109
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.56604941
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.55648835
45MYC_22102868_ChIP-Seq_BL_Human1.55259127
46AHR_22903824_ChIP-Seq_MCF-7_Human1.54933419
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.53301162
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52553700
49ZNF263_19887448_ChIP-Seq_K562_Human1.51103987
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.50791283
51ER_23166858_ChIP-Seq_MCF-7_Human1.50714745
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49017040
53BRD4_25478319_ChIP-Seq_HGPS_Human1.48565187
54STAT3_23295773_ChIP-Seq_U87_Human1.47642999
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.46169744
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.45469519
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45052365
58SMAD4_21799915_ChIP-Seq_A2780_Human1.45038766
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.44004277
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41941219
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.41684934
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40812903
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37368260
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37029028
65FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36974804
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36862719
67GATA1_22025678_ChIP-Seq_K562_Human1.36601714
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35420305
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.34677320
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.33374227
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31960406
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.31012310
73* TFEB_21752829_ChIP-Seq_HELA_Human1.30966126
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30743115
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.30449856
76IGF1R_20145208_ChIP-Seq_DFB_Human1.29225197
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28000556
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27199966
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25089888
80TCF4_23295773_ChIP-Seq_U87_Human1.24980605
81CMYC_18555785_Chip-Seq_ESCs_Mouse1.24797268
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24391553
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24173688
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24094846
85TP53_16413492_ChIP-PET_HCT116_Human1.23835471
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23234773
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23196629
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21092410
89BCAT_22108803_ChIP-Seq_LS180_Human1.20650547
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20584208
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20318647
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19905619
93FUS_26573619_Chip-Seq_HEK293_Human1.19332023
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19183488
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19175656
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18736203
97P53_22387025_ChIP-Seq_ESCs_Mouse1.17871947
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.17113748
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16890037
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16728614
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16080972
102MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15701098
103RNF2_27304074_Chip-Seq_NSC_Mouse1.15485985
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15088686
105PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15051114
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14913148
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14670465
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14231974
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12587789
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.12118783
111CHD1_26751641_Chip-Seq_LNCaP_Human1.12065295
112P300_18555785_Chip-Seq_ESCs_Mouse1.11549528
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11017760
114CBP_20019798_ChIP-Seq_JUKART_Human1.10450397
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10450397
116AR_25329375_ChIP-Seq_VCAP_Human1.10121513
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09752400
118FOXA2_19822575_ChIP-Seq_HepG2_Human1.09555245
119TCF7_22412390_ChIP-Seq_EML_Mouse1.08794696
120MYC_18555785_ChIP-Seq_MESCs_Mouse1.08432518
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08063805
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08022423
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07839944
124SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06844599
125SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06844599
126NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06394690
127RUNX2_22187159_ChIP-Seq_PCA_Human1.06254231
128ELK1_19687146_ChIP-ChIP_HELA_Human1.04520838
129MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04236785
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03901838
131SOX2_18555785_Chip-Seq_ESCs_Mouse1.03519183
132OCT4_18555785_Chip-Seq_ESCs_Mouse1.03351065
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03334418
134NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03334418
135P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03224057
136SOX2_21211035_ChIP-Seq_LN229_Gbm1.03040782
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.02964954
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02362962
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02224111
140SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02210382
141TCF4_22108803_ChIP-Seq_LS180_Human1.02044538
142P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01838468
143MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01393404
144TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00259038
145STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97793687
146* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97343526
147EWS_26573619_Chip-Seq_HEK293_Human0.96338181
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95495757
149TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94126132
150TCF4_18268006_ChIP-ChIP_LS174T_Human0.93710816
151NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92286719
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90815056
153NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90704941
154ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90479353
155PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87408179
156STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87319096
157SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86745918
158TP63_17297297_ChIP-ChIP_HaCaT_Human0.85219605
159* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84344575
160NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83342381
161HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82631380
162NCOR1_26117541_ChIP-Seq_K562_Human0.82570672
163POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81076957
164KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79964312
165FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79683971
166MYB_26560356_Chip-Seq_TH1_Human0.78724295
167CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77032904
168PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76202824
169KDM2B_26808549_Chip-Seq_DND41_Human0.75751980
170* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75432470
171TBX3_20139965_ChIP-Seq_ESCs_Mouse0.75094940
172CJUN_26792858_Chip-Seq_BT549_Human0.73765102
173ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.73764090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.45785575
2MP0003705_abnormal_hypodermis_morpholog3.77964244
3MP0010352_gastrointestinal_tract_polyps3.28896228
4MP0004185_abnormal_adipocyte_glucose2.98248980
5MP0005076_abnormal_cell_differentiation2.97327570
6MP0003787_abnormal_imprinting2.92023892
7MP0002160_abnormal_reproductive_system2.81788915
8MP0008057_abnormal_DNA_replication2.78084831
9MP0003195_calcinosis2.77631064
10MP0000569_abnormal_digit_pigmentation2.57474246
11MP0010307_abnormal_tumor_latency2.50271208
12MP0005666_abnormal_adipose_tissue2.36155690
13MP0005275_abnormal_skin_tensile2.32855476
14MP0002139_abnormal_hepatobiliary_system2.32806557
15MP0001177_atelectasis2.30927100
16MP0001188_hyperpigmentation2.28568637
17MP0004134_abnormal_chest_morphology2.17522638
18MP0004272_abnormal_basement_membrane2.16568252
19MP0002138_abnormal_hepatobiliary_system2.08555070
20MP0002009_preneoplasia2.07648595
21MP0010094_abnormal_chromosome_stability2.06481604
22MP0003122_maternal_imprinting2.01720050
23MP0005375_adipose_tissue_phenotype1.97342312
24MP0005409_darkened_coat_color1.90754081
25* MP0003111_abnormal_nucleus_morphology1.86223808
26MP0003077_abnormal_cell_cycle1.86185614
27MP0003123_paternal_imprinting1.80189890
28MP0002877_abnormal_melanocyte_morpholog1.77364895
29MP0003566_abnormal_cell_adhesion1.77066951
30MP0006292_abnormal_olfactory_placode1.75863241
31MP0005623_abnormal_meninges_morphology1.74407778
32MP0003890_abnormal_embryonic-extraembry1.73964677
33MP0004130_abnormal_muscle_cell1.72198336
34MP0004197_abnormal_fetal_growth/weight/1.70816977
35MP0005389_reproductive_system_phenotype1.67664570
36MP0000003_abnormal_adipose_tissue1.67099154
37MP0006054_spinal_hemorrhage1.61054420
38MP0005670_abnormal_white_adipose1.59881859
39MP0008007_abnormal_cellular_replicative1.57428514
40MP0000733_abnormal_muscle_development1.55447842
41MP0002396_abnormal_hematopoietic_system1.55167144
42MP0004885_abnormal_endolymph1.54950878
43MP0010234_abnormal_vibrissa_follicle1.53488881
44MP0001730_embryonic_growth_arrest1.53319481
45MP0003300_gastrointestinal_ulcer1.51151250
46MP0001485_abnormal_pinna_reflex1.49737260
47MP0000350_abnormal_cell_proliferation1.48983981
48MP0000537_abnormal_urethra_morphology1.46967825
49MP0004957_abnormal_blastocyst_morpholog1.46881193
50MP0002006_tumorigenesis1.46011367
51MP0002166_altered_tumor_susceptibility1.41531087
52MP0005503_abnormal_tendon_morphology1.41046130
53MP0003121_genomic_imprinting1.35589815
54MP0005380_embryogenesis_phenotype1.34024879
55MP0001672_abnormal_embryogenesis/_devel1.34024879
56MP0002089_abnormal_postnatal_growth/wei1.33113641
57MP0003693_abnormal_embryo_hatching1.32822334
58MP0002086_abnormal_extraembryonic_tissu1.32709200
59MP0002233_abnormal_nose_morphology1.32689302
60MP0003091_abnormal_cell_migration1.31286016
61MP0009053_abnormal_anal_canal1.29754904
62MP0003984_embryonic_growth_retardation1.26923518
63MP0000631_abnormal_neuroendocrine_gland1.26820694
64MP0002088_abnormal_embryonic_growth/wei1.25515058
65MP0003937_abnormal_limbs/digits/tail_de1.24024478
66MP0003279_aneurysm1.23559140
67MP0001286_abnormal_eye_development1.23389327
68MP0002210_abnormal_sex_determination1.23331794
69MP0000049_abnormal_middle_ear1.21993814
70MP0003755_abnormal_palate_morphology1.21634838
71MP0001697_abnormal_embryo_size1.17598062
72MP0002084_abnormal_developmental_patter1.17472357
73* MP0001145_abnormal_male_reproductive1.15169115
74MP0001929_abnormal_gametogenesis1.14912460
75MP0010678_abnormal_skin_adnexa1.13753970
76MP0005248_abnormal_Harderian_gland1.13493751
77MP0003943_abnormal_hepatobiliary_system1.13203324
78MP0002928_abnormal_bile_duct1.12524127
79MP0002085_abnormal_embryonic_tissue1.12518696
80MP0009703_decreased_birth_body1.12249992
81MP0003567_abnormal_fetal_cardiomyocyte1.11824978
82MP0002060_abnormal_skin_morphology1.10625581
83MP0000778_abnormal_nervous_system1.10624606
84MP0000428_abnormal_craniofacial_morphol1.10609536
85MP0010030_abnormal_orbit_morphology1.10030776
86* MP0000653_abnormal_sex_gland1.08481315
87MP0001919_abnormal_reproductive_system1.05989547
88MP0003936_abnormal_reproductive_system1.05832047
89MP0002102_abnormal_ear_morphology1.05114542
90MP0003252_abnormal_bile_duct1.04559774
91MP0004808_abnormal_hematopoietic_stem1.04159126
92MP0000013_abnormal_adipose_tissue1.03719048
93MP0009278_abnormal_bone_marrow1.03006107
94MP0005187_abnormal_penis_morphology1.02679108
95MP0009672_abnormal_birth_weight1.02368775
96MP0000858_altered_metastatic_potential1.00591549
97MP0005397_hematopoietic_system_phenotyp0.97090331
98MP0001545_abnormal_hematopoietic_system0.97090331
99MP0003935_abnormal_craniofacial_develop0.97035552
100MP0008877_abnormal_DNA_methylation0.96264200
101MP0002249_abnormal_larynx_morphology0.95110188
102MP0002925_abnormal_cardiovascular_devel0.95048854
103MP0004270_analgesia0.94985998
104MP0009115_abnormal_fat_cell0.93797603
105* MP0003861_abnormal_nervous_system0.93611684
106MP0000383_abnormal_hair_follicle0.92813014
107MP0003938_abnormal_ear_development0.92803627
108MP0003183_abnormal_peptide_metabolism0.92569571
109MP0003941_abnormal_skin_development0.92484345
110MP0004264_abnormal_extraembryonic_tissu0.91059399
111MP0008932_abnormal_embryonic_tissue0.90404559
112MP0002697_abnormal_eye_size0.90079692
113MP0005174_abnormal_tail_pigmentation0.90070651
114MP0000490_abnormal_crypts_of0.90039237
115MP0005023_abnormal_wound_healing0.89445270
116MP0001915_intracranial_hemorrhage0.87666691
117MP0003448_altered_tumor_morphology0.87539752
118MP0009250_abnormal_appendicular_skeleto0.86912695
119MP0000427_abnormal_hair_cycle0.86786262
120MP0003698_abnormal_male_reproductive0.85514655
121MP0008058_abnormal_DNA_repair0.84429594
122MP0000432_abnormal_head_morphology0.84355993
123MP0001243_abnormal_dermal_layer0.84192669
124MP0002111_abnormal_tail_morphology0.83441907
125MP0002116_abnormal_craniofacial_bone0.83378826
126MP0005646_abnormal_pituitary_gland0.82636109
127MP0003315_abnormal_perineum_morphology0.82468258
128MP0002971_abnormal_brown_adipose0.82458457
129MP0009780_abnormal_chondrocyte_physiolo0.82274523
130MP0002080_prenatal_lethality0.81817113
131MP0003942_abnormal_urinary_system0.81475033
132MP0000627_abnormal_mammary_gland0.81217912
133MP0002896_abnormal_bone_mineralization0.81177665
134MP0000678_abnormal_parathyroid_gland0.81021995
135MP0009697_abnormal_copulation0.78603179
136MP0003880_abnormal_central_pattern0.78210442
137MP0001119_abnormal_female_reproductive0.78078573
138MP0001661_extended_life_span0.77686560
139MP0003868_abnormal_feces_composition0.77668066
140MP0002970_abnormal_white_adipose0.76887745
141MP0003632_abnormal_nervous_system0.75958011
142MP0003115_abnormal_respiratory_system0.75523797
143MP0005508_abnormal_skeleton_morphology0.75523210
144MP0002019_abnormal_tumor_incidence0.73762527
145MP0003283_abnormal_digestive_organ0.73587241
146MP0002114_abnormal_axial_skeleton0.73512575
147MP0003699_abnormal_female_reproductive0.73355717
148MP0002081_perinatal_lethality0.72926714
149MP0003385_abnormal_body_wall0.72117552
150MP0002876_abnormal_thyroid_physiology0.69987126
151MP0003119_abnormal_digestive_system0.69547086
152MP0003453_abnormal_keratinocyte_physiol0.65399677
153MP0001614_abnormal_blood_vessel0.65229130
154MP0001293_anophthalmia0.64674788
155MP0002254_reproductive_system_inflammat0.63101243

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)3.77046204
2Volvulus (HP:0002580)3.72971492
3Papillary thyroid carcinoma (HP:0002895)3.45175653
4Shallow orbits (HP:0000586)3.44391382
5Genetic anticipation (HP:0003743)3.43656485
6Protrusio acetabuli (HP:0003179)3.22751260
7Subacute progressive viral hepatitis (HP:0006572)2.99259622
8Vertebral arch anomaly (HP:0008438)2.95487235
9Abnormality of the astrocytes (HP:0100707)2.94619474
10Astrocytoma (HP:0009592)2.94619474
11Ependymoma (HP:0002888)2.90370644
12Chromsome breakage (HP:0040012)2.84657609
13Premature rupture of membranes (HP:0001788)2.81162717
14Cerebral aneurysm (HP:0004944)2.69467948
15Short 4th metacarpal (HP:0010044)2.63812882
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63812882
17Absent frontal sinuses (HP:0002688)2.61615101
18Selective tooth agenesis (HP:0001592)2.60035496
19Curly hair (HP:0002212)2.56830156
20Medulloblastoma (HP:0002885)2.56538091
21High pitched voice (HP:0001620)2.55685471
22Progressive cerebellar ataxia (HP:0002073)2.54376732
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43780881
24Thickened helices (HP:0000391)2.40264706
25Thyroid carcinoma (HP:0002890)2.38051937
26Genu recurvatum (HP:0002816)2.35202161
27Spinal cord lesions (HP:0100561)2.33716523
28Syringomyelia (HP:0003396)2.33716523
29Osteomalacia (HP:0002749)2.32460316
30Asymmetry of the thorax (HP:0001555)2.29125846
31Abnormality of the 4th metacarpal (HP:0010012)2.28415846
32Rectal prolapse (HP:0002035)2.26460274
33Glioma (HP:0009733)2.23017759
34* Mitral valve prolapse (HP:0001634)2.22383860
352-3 toe syndactyly (HP:0004691)2.21418901
36* Dilatation of the ascending aorta (HP:0005111)2.21256964
37Increased nuchal translucency (HP:0010880)2.20933595
38Hamartoma (HP:0010566)2.17602219
39Deviation of the thumb (HP:0009603)2.15682768
40* Macroorchidism (HP:0000053)2.12664557
41Hematochezia (HP:0002573)2.12364460
42Enlarged penis (HP:0000040)2.11413354
43Osteolytic defects of the hand bones (HP:0009699)2.11125237
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.11125237
45Abnormal lung lobation (HP:0002101)2.10719616
46Abnormality of homocysteine metabolism (HP:0010919)2.08723337
47Homocystinuria (HP:0002156)2.08723337
48Bowel diverticulosis (HP:0005222)2.08684372
49Aortic aneurysm (HP:0004942)2.08625456
50Diastasis recti (HP:0001540)2.07577196
51Spontaneous abortion (HP:0005268)2.05852150
52Aortic dissection (HP:0002647)2.04983322
53Deviation of the hallux (HP:0010051)2.04480921
54Bladder diverticulum (HP:0000015)2.04058839
55Mesomelia (HP:0003027)2.03139868
56Proximal placement of thumb (HP:0009623)2.02524323
57Hallux valgus (HP:0001822)2.02340491
58Gaze-evoked nystagmus (HP:0000640)2.01958179
59Neoplasm of the thyroid gland (HP:0100031)2.01361157
60Deep philtrum (HP:0002002)1.99502819
61* Heterotopia (HP:0002282)1.99087501
62Missing ribs (HP:0000921)1.98800770
63Submucous cleft hard palate (HP:0000176)1.98507149
64Leiomyosarcoma (HP:0100243)1.98374122
65Uterine leiomyosarcoma (HP:0002891)1.98374122
66Cystic hygroma (HP:0000476)1.97519607
67* Truncal obesity (HP:0001956)1.97378315
68Exostoses (HP:0100777)1.96832888
69Gastrointestinal carcinoma (HP:0002672)1.95501641
70Malignant gastrointestinal tract tumors (HP:0006749)1.95501641
71Follicular hyperkeratosis (HP:0007502)1.94630225
72Aqueductal stenosis (HP:0002410)1.94575845
73* Abnormality of chromosome stability (HP:0003220)1.93547934
74Broad palm (HP:0001169)1.92318235
75Lymphangioma (HP:0100764)1.91668584
76Ulnar bowing (HP:0003031)1.91613529
77Colon cancer (HP:0003003)1.91267489
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.89649545
79Hypoplastic iliac wings (HP:0002866)1.88933471
80Cervical subluxation (HP:0003308)1.88199566
81Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88190820
82Abnormality of the corticospinal tract (HP:0002492)1.88094531
83Drooling (HP:0002307)1.87413310
84Fibrous tissue neoplasm (HP:0012316)1.86909380
85Cutaneous melanoma (HP:0012056)1.86572823
86Hypobetalipoproteinemia (HP:0003563)1.86299642
87Absent eyebrow (HP:0002223)1.85519896
88Neoplasm of striated muscle (HP:0009728)1.84068271
89Acute myeloid leukemia (HP:0004808)1.83797511
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82898398
91Ectopic kidney (HP:0000086)1.82741662
92Megalencephaly (HP:0001355)1.82532305
93Oligodactyly (hands) (HP:0001180)1.82084639
94Abnormality of the lower motor neuron (HP:0002366)1.81730999
95Wrist flexion contracture (HP:0001239)1.80624600
96Impulsivity (HP:0100710)1.79232230
97Acanthosis nigricans (HP:0000956)1.78990037
98Wide intermamillary distance (HP:0006610)1.77945553
99Long eyelashes (HP:0000527)1.77593006
100Abnormality of methionine metabolism (HP:0010901)1.77527116
101Abnormality of the nasal septum (HP:0000419)1.77414690
102Rhabdomyosarcoma (HP:0002859)1.77330842
103Cubitus valgus (HP:0002967)1.77150559
104Biliary tract neoplasm (HP:0100574)1.77089505
105Narrow palate (HP:0000189)1.76822994
106Soft skin (HP:0000977)1.75932327
107Fair hair (HP:0002286)1.75517150
108Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75394441
109Embryonal renal neoplasm (HP:0011794)1.75239605
110Short middle phalanx of the 5th finger (HP:0004220)1.74951212
111Uterine neoplasm (HP:0010784)1.74257947
112Excessive salivation (HP:0003781)1.74192397
113Abnormality of the middle phalanges of the toes (HP:0010183)1.73209091
114Transitional cell carcinoma of the bladder (HP:0006740)1.72366511
115Delayed closure of the anterior fontanelle (HP:0001476)1.72310062
116Hepatoblastoma (HP:0002884)1.72083021
117Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71784392
118Hypopigmentation of the fundus (HP:0007894)1.71649861
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.71445670
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71445670
121Wide nose (HP:0000445)1.70919715
122Increased mean platelet volume (HP:0011877)1.70781043
123Cutaneous finger syndactyly (HP:0010554)1.70478625
124Cafe-au-lait spot (HP:0000957)1.70384423
125Prominent nose (HP:0000448)1.69192851
126Abnormality of the phalanges of the 5th finger (HP:0004213)1.69118287
127Impaired vibration sensation in the lower limbs (HP:0002166)1.69038374
128Large earlobe (HP:0009748)1.68622362
129Dislocated radial head (HP:0003083)1.68379221
130Abnormal pancreas size (HP:0012094)1.67685849
131Striae distensae (HP:0001065)1.66517987
132Hypoplastic pelvis (HP:0008839)1.66165660
133Embryonal neoplasm (HP:0002898)1.66006716
134Renal duplication (HP:0000075)1.65917805
135Bladder carcinoma (HP:0002862)1.65809218
136Bladder neoplasm (HP:0009725)1.65809218
137Ankyloglossia (HP:0010296)1.65663643
138Aneurysm (HP:0002617)1.65439570
139Acanthocytosis (HP:0001927)1.65071756
140Abnormality of the peritoneum (HP:0002585)1.65022977
141Tibial bowing (HP:0002982)1.64759855
142Thickened calvaria (HP:0002684)1.64636534
143Nephroblastoma (Wilms tumor) (HP:0002667)1.64280932
144Slender build (HP:0001533)1.63837176
145Abnormal biliary tract morphology (HP:0012440)1.63683828
146Camptodactyly of toe (HP:0001836)1.63647596
147Low anterior hairline (HP:0000294)1.62492462
148Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.62089032
149Abnormality of oral frenula (HP:0000190)1.61947073
150Long nose (HP:0003189)1.61870666
151Neoplasm of the oral cavity (HP:0100649)1.61869739
152Hyperinsulinemic hypoglycemia (HP:0000825)1.61669214
153Wormian bones (HP:0002645)1.60058421
154Abnormality of cochlea (HP:0000375)1.59849784
155Coronal craniosynostosis (HP:0004440)1.59762117
156Papilledema (HP:0001085)1.59714386
157Broad thumb (HP:0011304)1.58923488
158Abnormality of the frontal sinuses (HP:0002687)1.58846262
159Febrile seizures (HP:0002373)1.58769423
160Abnormality of the carotid arteries (HP:0005344)1.57659804
161Fibroma (HP:0010614)1.57602284
162Thin bony cortex (HP:0002753)1.57419999
163Anal stenosis (HP:0002025)1.57290606
164Abnormality of the parietal bone (HP:0002696)1.57172221
165Urinary bladder sphincter dysfunction (HP:0002839)1.56450541
166Abnormality of the wing of the ilium (HP:0011867)1.56429531
167Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.55875636
168Breast carcinoma (HP:0003002)1.55789511
169Plagiocephaly (HP:0001357)1.54747077
170Abnormality of DNA repair (HP:0003254)1.53471135
171Hamartoma of the eye (HP:0010568)1.53202446
172Small hand (HP:0200055)1.52247052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.63506729
2TRIB34.22058774
3RIPK14.12123587
4TNIK3.76998398
5CDK123.64758414
6CDC73.37585420
7TAF12.82014751
8AKT32.50103229
9NLK2.44557146
10NEK22.25085396
11CAMK1D2.22617116
12RPS6KA42.17696126
13CDK62.15867768
14EIF2AK12.10519489
15MAP3K92.08902689
16PDGFRA1.98439035
17ACVR1B1.98277437
18DDR21.96084880
19STK31.91034635
20STK38L1.88366553
21CASK1.85625221
22LATS11.77931454
23SGK21.71903341
24PKN21.68521291
25WNK11.65926128
26SCYL21.63929316
27CDK41.60700559
28ERBB31.55810609
29PTK61.51757788
30FGFR31.50334737
31STK241.50169249
32EPHA41.45273841
33ATR1.44373366
34MET1.42043137
35ALK1.39744448
36WEE11.39623291
37NEK91.38527871
38EEF2K1.38177195
39MKNK11.36688773
40STK101.34759888
41SGK31.32431198
42BMX1.31085473
43FRK1.31078149
44FLT31.26627453
45TTK1.24564981
46MELK1.24369837
47PDGFRB1.22959886
48TTN1.18588867
49EIF2AK21.17322137
50CAMK1G1.14787527
51BRSK11.13018363
52GRK11.12413010
53FGFR21.11458335
54DYRK31.10348996
55EIF2AK31.10336474
56CDK91.09491456
57KSR11.09279401
58MAP3K81.07703097
59MKNK21.06686076
60PLK31.01598100
61RIPK41.01514613
62BCR0.97786381
63PLK10.96423055
64TRPM70.96126940
65PAK40.95610171
66ATM0.95249876
67BMPR1B0.94559735
68SGK2230.94069834
69SGK4940.94069834
70BRSK20.93714025
71CHEK10.92272746
72LATS20.88635695
73STK390.86239786
74CHEK20.85626470
75TRIM280.84691948
76SGK10.83789197
77MAP3K100.82184365
78AURKB0.81083565
79CDK70.80102106
80FGFR10.80046610
81TYRO30.79753233
82PAK20.79326057
83MTOR0.79040511
84FGFR40.76332472
85BRD40.75583733
86STK110.71841253
87NTRK30.70864834
88BRAF0.67453690
89PAK30.66030002
90INSR0.64321450
91MST40.64258742
92ERBB20.63740594
93NEK60.63230296
94PIK3CA0.62352403
95CSNK1E0.62086567
96CDK20.60695985
97OXSR10.60348408
98RET0.60139551
99LRRK20.59465247
100SRPK10.58881760
101PLK40.58746849
102CDK30.58569866
103SIK30.58215764
104PBK0.57619686
105WNK30.56267510
106SIK10.55711141
107CHUK0.54695566
108DMPK0.54473211
109NEK10.53331079
110TGFBR10.53010524
111PTK20.52988225
112TEC0.50303102
113DYRK1A0.48911840
114PIM10.48260916
115PRKDC0.48138784
116PRKCE0.47387592
117STK40.47050555
118RPS6KB20.46845977
119GSK3A0.46659975
120CDK10.46574873
121MAPK100.44390448
122CSNK1D0.44119264
123YES10.43752538
124FER0.41864320
125JAK10.41553078
126PINK10.41186895
127IRAK10.40991922
128NUAK10.40860109
129HIPK20.40136879
130NTRK20.39631260
131STK380.39272596
132MAPK140.38772411
133FGR0.38639083
134MAP3K130.37453607
135* RPS6KB10.35945223
136JAK30.35494561
137MAPK10.35331142
138PLK20.34970600
139PRKD20.34947161
140EPHB20.34342861
141EGFR0.32503460
142RPS6KA60.32415573
143PASK0.32413053
144AKT10.32229017
145PRKCG0.31999456
146MINK10.31711945
147IRAK20.31515030
148RPS6KC10.30617478
149RPS6KL10.30617478
150MAP3K20.29496460
151CSF1R0.29052918
152PRKCH0.29028102

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.43077222
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.39800384
3p53 signaling pathway_Homo sapiens_hsa041151.92518879
4Long-term potentiation_Homo sapiens_hsa047201.85586417
5MicroRNAs in cancer_Homo sapiens_hsa052061.81576999
6Small cell lung cancer_Homo sapiens_hsa052221.81251685
7Chronic myeloid leukemia_Homo sapiens_hsa052201.73341211
8* RNA transport_Homo sapiens_hsa030131.68540115
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66957347
10Adherens junction_Homo sapiens_hsa045201.63047643
11Mismatch repair_Homo sapiens_hsa034301.59796143
12Proteoglycans in cancer_Homo sapiens_hsa052051.59328250
13mTOR signaling pathway_Homo sapiens_hsa041501.58036489
14DNA replication_Homo sapiens_hsa030301.53837405
15Viral carcinogenesis_Homo sapiens_hsa052031.51850477
16Hedgehog signaling pathway_Homo sapiens_hsa043401.47516391
17Nicotine addiction_Homo sapiens_hsa050331.43402359
18Focal adhesion_Homo sapiens_hsa045101.43169809
19Circadian rhythm_Homo sapiens_hsa047101.42679483
20TGF-beta signaling pathway_Homo sapiens_hsa043501.42166410
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40664009
22Prostate cancer_Homo sapiens_hsa052151.38197973
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37176665
24Colorectal cancer_Homo sapiens_hsa052101.35205961
25ECM-receptor interaction_Homo sapiens_hsa045121.34719479
26mRNA surveillance pathway_Homo sapiens_hsa030151.34110606
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30673164
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.30467990
29Pancreatic cancer_Homo sapiens_hsa052121.27689998
30Oocyte meiosis_Homo sapiens_hsa041141.26432965
31Hippo signaling pathway_Homo sapiens_hsa043901.25913078
32Basal transcription factors_Homo sapiens_hsa030221.24521115
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24318265
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24076016
35Glioma_Homo sapiens_hsa052141.23726339
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20171893
37HTLV-I infection_Homo sapiens_hsa051661.17121110
38AMPK signaling pathway_Homo sapiens_hsa041521.16908481
39Spliceosome_Homo sapiens_hsa030401.16477485
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14708404
41Fanconi anemia pathway_Homo sapiens_hsa034601.14150949
42Endometrial cancer_Homo sapiens_hsa052131.13493491
43TNF signaling pathway_Homo sapiens_hsa046681.13413148
44Non-small cell lung cancer_Homo sapiens_hsa052231.10812359
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08269899
46Inositol phosphate metabolism_Homo sapiens_hsa005621.08152079
47Melanoma_Homo sapiens_hsa052181.07809389
48Hepatitis B_Homo sapiens_hsa051611.07763060
49Thyroid cancer_Homo sapiens_hsa052161.04559319
50Thyroid hormone synthesis_Homo sapiens_hsa049181.04466185
51Non-homologous end-joining_Homo sapiens_hsa034501.03100651
52Renin secretion_Homo sapiens_hsa049241.02922345
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01621519
54Systemic lupus erythematosus_Homo sapiens_hsa053221.01490266
55RNA degradation_Homo sapiens_hsa030181.01200835
56One carbon pool by folate_Homo sapiens_hsa006701.01074294
57Glutamatergic synapse_Homo sapiens_hsa047240.98856768
58Herpes simplex infection_Homo sapiens_hsa051680.98230853
59Pathways in cancer_Homo sapiens_hsa052000.97577893
60FoxO signaling pathway_Homo sapiens_hsa040680.96836856
61Amphetamine addiction_Homo sapiens_hsa050310.96671078
62Shigellosis_Homo sapiens_hsa051310.96310249
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.93886004
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.93349800
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92744189
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92675530
67Fatty acid biosynthesis_Homo sapiens_hsa000610.92249398
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.91869505
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.91280214
70Bladder cancer_Homo sapiens_hsa052190.90784355
71Apoptosis_Homo sapiens_hsa042100.90434619
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90262543
73Legionellosis_Homo sapiens_hsa051340.89607763
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89400094
75Long-term depression_Homo sapiens_hsa047300.88801905
76Nucleotide excision repair_Homo sapiens_hsa034200.88526965
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.88188817
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.88135997
79Basal cell carcinoma_Homo sapiens_hsa052170.86726510
80Platelet activation_Homo sapiens_hsa046110.86590277
81cAMP signaling pathway_Homo sapiens_hsa040240.86263166
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86091418
83Dorso-ventral axis formation_Homo sapiens_hsa043200.85638232
84Prolactin signaling pathway_Homo sapiens_hsa049170.85587637
85Complement and coagulation cascades_Homo sapiens_hsa046100.84529973
86Amoebiasis_Homo sapiens_hsa051460.84242260
87B cell receptor signaling pathway_Homo sapiens_hsa046620.83799774
88Ras signaling pathway_Homo sapiens_hsa040140.83633624
89Toxoplasmosis_Homo sapiens_hsa051450.82743801
90Insulin secretion_Homo sapiens_hsa049110.82202542
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82187079
92Lysine degradation_Homo sapiens_hsa003100.80875321
93Leishmaniasis_Homo sapiens_hsa051400.80683482
94Dopaminergic synapse_Homo sapiens_hsa047280.78830600
95Homologous recombination_Homo sapiens_hsa034400.78083089
96Acute myeloid leukemia_Homo sapiens_hsa052210.77389024
97Melanogenesis_Homo sapiens_hsa049160.77154568
98Viral myocarditis_Homo sapiens_hsa054160.76835757
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76139919
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75838105
101T cell receptor signaling pathway_Homo sapiens_hsa046600.75430422
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75304268
103Base excision repair_Homo sapiens_hsa034100.74843606
104Cholinergic synapse_Homo sapiens_hsa047250.74056375
105Measles_Homo sapiens_hsa051620.73646989
106VEGF signaling pathway_Homo sapiens_hsa043700.73356124
107Osteoclast differentiation_Homo sapiens_hsa043800.72600156
108Gap junction_Homo sapiens_hsa045400.72388830
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71895176
110Renal cell carcinoma_Homo sapiens_hsa052110.71429421
111Glucagon signaling pathway_Homo sapiens_hsa049220.71419074
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71251565
113Vitamin digestion and absorption_Homo sapiens_hsa049770.70914979
114MAPK signaling pathway_Homo sapiens_hsa040100.70450939
115Estrogen signaling pathway_Homo sapiens_hsa049150.69585407
116Insulin resistance_Homo sapiens_hsa049310.69355792
117Morphine addiction_Homo sapiens_hsa050320.69071363
118HIF-1 signaling pathway_Homo sapiens_hsa040660.67992656
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66555604
120Rap1 signaling pathway_Homo sapiens_hsa040150.65944159
121Insulin signaling pathway_Homo sapiens_hsa049100.65463811
122Circadian entrainment_Homo sapiens_hsa047130.65213115
123ErbB signaling pathway_Homo sapiens_hsa040120.65103756
124Antigen processing and presentation_Homo sapiens_hsa046120.63486331
125Selenocompound metabolism_Homo sapiens_hsa004500.63426573
126Tight junction_Homo sapiens_hsa045300.62118705
127ABC transporters_Homo sapiens_hsa020100.61310784
128Vitamin B6 metabolism_Homo sapiens_hsa007500.61177616
129Chemokine signaling pathway_Homo sapiens_hsa040620.60959996
130Type II diabetes mellitus_Homo sapiens_hsa049300.60703971
131Epstein-Barr virus infection_Homo sapiens_hsa051690.59701621
132GnRH signaling pathway_Homo sapiens_hsa049120.58968686
133Choline metabolism in cancer_Homo sapiens_hsa052310.58259339
134Wnt signaling pathway_Homo sapiens_hsa043100.57613685
135Alcoholism_Homo sapiens_hsa050340.57332847
136PPAR signaling pathway_Homo sapiens_hsa033200.55843406
137Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54411218
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.53556757
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.52621761
140Gastric acid secretion_Homo sapiens_hsa049710.50592411
141GABAergic synapse_Homo sapiens_hsa047270.50146823
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50003080
143Axon guidance_Homo sapiens_hsa043600.47994697
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45868279
145Hepatitis C_Homo sapiens_hsa051600.45194240

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