FN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)6.34774242
2chondrocyte proliferation (GO:0035988)6.32822952
3hemidesmosome assembly (GO:0031581)5.81215247
4protein heterotrimerization (GO:0070208)5.57571501
5cell adhesion mediated by integrin (GO:0033627)5.47876739
6* endodermal cell differentiation (GO:0035987)5.34390422
7apoptotic cell clearance (GO:0043277)5.26319429
8skin morphogenesis (GO:0043589)4.99541163
9positive regulation of endothelial cell apoptotic process (GO:2000353)4.84979010
10sequestering of extracellular ligand from receptor (GO:0035581)4.77733377
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.61505861
12basement membrane organization (GO:0071711)4.59771842
13regulation of integrin activation (GO:0033623)4.41556959
14bone trabecula formation (GO:0060346)4.40426187
15wound healing, spreading of epidermal cells (GO:0035313)4.32072732
16negative regulation of fatty acid transport (GO:2000192)4.24485240
17collagen metabolic process (GO:0032963)4.11684009
18cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.08279026
19regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.03901568
20collagen catabolic process (GO:0030574)4.03764586
21mesenchymal-epithelial cell signaling (GO:0060638)3.97900005
22protein retention in ER lumen (GO:0006621)3.93814214
23negative regulation of fibrinolysis (GO:0051918)3.93265088
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.93026031
25epithelial cell-cell adhesion (GO:0090136)3.89900641
26COPI coating of Golgi vesicle (GO:0048205)3.85443821
27Golgi transport vesicle coating (GO:0048200)3.85443821
28multicellular organismal macromolecule metabolic process (GO:0044259)3.84029979
29axon extension involved in axon guidance (GO:0048846)3.75114573
30neuron projection extension involved in neuron projection guidance (GO:1902284)3.75114573
31plasma membrane repair (GO:0001778)3.73438446
32multicellular organismal catabolic process (GO:0044243)3.66863229
33outer ear morphogenesis (GO:0042473)3.66320824
34cell migration involved in heart development (GO:0060973)3.64254262
35regulation of apoptotic cell clearance (GO:2000425)3.64066658
36multicellular organismal metabolic process (GO:0044236)3.60549517
37mesodermal cell differentiation (GO:0048333)3.59811649
38extracellular fibril organization (GO:0043206)3.59160267
39* extracellular matrix disassembly (GO:0022617)3.53118659
40wound healing, spreading of cells (GO:0044319)3.42013566
41heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.41773507
42hippo signaling (GO:0035329)3.40664296
43craniofacial suture morphogenesis (GO:0097094)3.40356154
44regulation of plasminogen activation (GO:0010755)3.36957341
45positive regulation of extracellular matrix organization (GO:1903055)3.36303086
46type B pancreatic cell proliferation (GO:0044342)3.30695185
47epoxygenase P450 pathway (GO:0019373)3.27459486
48negative regulation of smooth muscle cell migration (GO:0014912)3.24528194
49cellular response to vitamin D (GO:0071305)3.23916035
50protein localization to endosome (GO:0036010)3.21399262
51dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.20968375
52COPII vesicle coating (GO:0048208)3.20922128
53endocardial cushion development (GO:0003197)3.20353575
54positive regulation of epithelial to mesenchymal transition (GO:0010718)3.19468003
55response to fluid shear stress (GO:0034405)3.18530710
56endothelial cell morphogenesis (GO:0001886)3.17363824
57regulation of extracellular matrix disassembly (GO:0010715)3.15409797
58protein localization to cell surface (GO:0034394)3.15373940
59metanephric mesenchyme development (GO:0072075)3.15333752
60mannose metabolic process (GO:0006013)3.14747339
61glomerular basement membrane development (GO:0032836)3.13891826
62fibril organization (GO:0097435)3.12632435
63peptidyl-proline hydroxylation (GO:0019511)3.12259039
64dermatan sulfate biosynthetic process (GO:0030208)3.11640532
65cell migration involved in sprouting angiogenesis (GO:0002042)3.09855356
66vascular endothelial growth factor signaling pathway (GO:0038084)3.09764599
67hypotonic response (GO:0006971)3.09510655
68paraxial mesoderm development (GO:0048339)3.09084330
69negative regulation of chondrocyte differentiation (GO:0032331)3.09058030
70positive regulation of blood vessel endothelial cell migration (GO:0043536)3.08037058
71stress fiber assembly (GO:0043149)3.07903847
72virion attachment to host cell (GO:0019062)3.05761925
73adhesion of symbiont to host cell (GO:0044650)3.05761925
74positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.05535068
75cellular response to vitamin (GO:0071295)3.04752697
76adherens junction assembly (GO:0034333)3.04517058
77kidney mesenchyme development (GO:0072074)3.04037154
78insulin-like growth factor receptor signaling pathway (GO:0048009)3.00724255
79peptidyl-glutamic acid carboxylation (GO:0017187)2.99734222
80protein carboxylation (GO:0018214)2.99734222
81desmosome organization (GO:0002934)2.98354314
82retina vasculature morphogenesis in camera-type eye (GO:0061299)2.96833848
83barbed-end actin filament capping (GO:0051016)2.96667193
84focal adhesion assembly (GO:0048041)2.94574025
85cell-substrate adherens junction assembly (GO:0007045)2.94574025
86actin filament depolymerization (GO:0030042)2.93495305
87regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.93163263
88blood vessel endothelial cell migration (GO:0043534)2.92529890
89venous blood vessel morphogenesis (GO:0048845)2.91030346
90response to laminar fluid shear stress (GO:0034616)2.89430981
91cytoskeletal anchoring at plasma membrane (GO:0007016)2.89398124
92adhesion of symbiont to host (GO:0044406)2.89149654
93positive regulation of fibroblast migration (GO:0010763)2.88253472
94chondroitin sulfate biosynthetic process (GO:0030206)2.87173264
95regulation of fibrinolysis (GO:0051917)2.85611720
96* substrate adhesion-dependent cell spreading (GO:0034446)2.83265173
97regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.83210992
98blood vessel maturation (GO:0001955)2.83165553
99lymphangiogenesis (GO:0001946)2.83084394
100regulation of tight junction assembly (GO:2000810)2.82931614
101extracellular negative regulation of signal transduction (GO:1900116)2.82620242
102extracellular regulation of signal transduction (GO:1900115)2.82620242
103vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.82281497
104positive regulation of hemostasis (GO:1900048)2.82176247
105positive regulation of blood coagulation (GO:0030194)2.82176247
106* cell-substrate junction assembly (GO:0007044)2.81855450
107G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.81750542
108dermatan sulfate metabolic process (GO:0030205)2.80931871
109* extracellular matrix organization (GO:0030198)2.80703940
110* extracellular structure organization (GO:0043062)2.79782592
111negative regulation of axon extension involved in axon guidance (GO:0048843)2.78698118
112negative regulation of focal adhesion assembly (GO:0051895)2.76487719
113negative regulation of cell junction assembly (GO:1901889)2.76487719
114negative regulation of adherens junction organization (GO:1903392)2.76487719
115planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76408760
116regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.76189438
117extracellular matrix assembly (GO:0085029)2.75703596
118regulation of macrophage chemotaxis (GO:0010758)2.75149463
119regulation of transforming growth factor beta2 production (GO:0032909)2.74769710
120opsonization (GO:0008228)2.74157133
121pathway-restricted SMAD protein phosphorylation (GO:0060389)2.73920433
122positive regulation of endothelial cell migration (GO:0010595)2.73665115
123sprouting angiogenesis (GO:0002040)2.72701848
124tooth mineralization (GO:0034505)2.72512509
125* platelet degranulation (GO:0002576)2.72396102
126keratan sulfate catabolic process (GO:0042340)2.71806259
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70820685
128polarized epithelial cell differentiation (GO:0030859)2.70577828
129substrate-dependent cell migration (GO:0006929)2.70354717
130middle ear morphogenesis (GO:0042474)2.70328536
131regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.70087729
132regulation of metalloenzyme activity (GO:0048552)2.69972267
133chondrocyte development (GO:0002063)2.69658338
134positive regulation of collagen biosynthetic process (GO:0032967)2.69404317
135embryonic cranial skeleton morphogenesis (GO:0048701)2.69310316
136cellular response to amino acid stimulus (GO:0071230)2.68334648
137hyaluronan catabolic process (GO:0030214)2.67526089
138heparan sulfate proteoglycan metabolic process (GO:0030201)2.66186628
139protein hydroxylation (GO:0018126)2.65918401
140positive regulation of cell adhesion mediated by integrin (GO:0033630)2.65155655
141regulation of gastrulation (GO:0010470)2.64505203
142positive regulation of osteoblast proliferation (GO:0033690)2.64176045
143negative regulation of cartilage development (GO:0061037)2.63867951
144endothelial cell chemotaxis (GO:0035767)2.62556218
145wound healing (GO:0042060)2.62513182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.32466003
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.30129765
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse5.00761894
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.53730412
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.31319969
6CLOCK_20551151_ChIP-Seq_293T_Human3.20366684
7* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.19859125
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.11873046
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.97524639
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.83129711
11* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.55409611
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.37212020
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.30161904
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24472850
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.19552988
16* CJUN_26792858_Chip-Seq_BT549_Human2.14941893
17BRD4_25478319_ChIP-Seq_HGPS_Human2.09936144
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.03069917
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.01741214
20* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.99921767
21* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.94988887
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.94190979
23P300_27058665_Chip-Seq_ZR-75-30cells_Human1.85695875
24* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.84803579
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75114121
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75114121
27ATF3_27146783_Chip-Seq_COLON_Human1.74967395
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74212664
29* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68745094
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66956435
31* RXR_22158963_ChIP-Seq_LIVER_Mouse1.63220974
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.59935326
33TP53_22127205_ChIP-Seq_IMR90_Human1.59202695
34* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57917487
35* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57917487
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56184515
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55039279
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54062460
39TP53_16413492_ChIP-PET_HCT116_Human1.53476688
40* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50553010
41RACK7_27058665_Chip-Seq_MCF-7_Human1.49672119
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.49321676
43* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.48220093
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.47938900
45* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47510335
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47431743
47* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46785683
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46425684
49* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.46065969
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45975317
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41073620
52* UBF1/2_26484160_Chip-Seq_HMECs_Human1.40403690
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39672231
54* LXR_22158963_ChIP-Seq_LIVER_Mouse1.38853938
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37535368
56JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37314226
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36042977
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34995163
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34712588
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33781239
61LXR_22292898_ChIP-Seq_THP-1_Human1.32816559
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32075536
63* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31955961
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.31534827
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31354104
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31064507
67TP53_23651856_ChIP-Seq_MEFs_Mouse1.30813839
68JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28350121
69KDM2B_26808549_Chip-Seq_DND41_Human1.28215106
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.26858252
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.26358774
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.26166439
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25942899
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25621391
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24097972
76* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23349589
77FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23125216
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22618962
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.22438988
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18615059
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18303010
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18035783
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18035783
84* SOX2_20726797_ChIP-Seq_SW620_Human1.17237668
85* SA1_22415368_ChIP-Seq_MEFs_Mouse1.16795649
86* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15635090
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14729873
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13910061
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13370291
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08637968
91KDM2B_26808549_Chip-Seq_K562_Human1.08630644
92* TBX20_22080862_ChIP-Seq_HEART_Mouse1.08318587
93* TBX20_22328084_ChIP-Seq_HEART_Mouse1.08318587
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08202053
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07796182
96* FOXA2_19822575_ChIP-Seq_HepG2_Human1.07280116
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.06766062
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06052234
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05093115
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03723978
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03258170
102P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02968880
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.02840423
104* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02070360
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01726658
106TP53_18474530_ChIP-ChIP_U2OS_Human1.01596717
107BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01399186
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00772146
109TCF7_22412390_ChIP-Seq_EML_Mouse1.00065934
110NCOR1_26117541_ChIP-Seq_K562_Human0.99180233
111* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99166996
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97989723
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97868005
114STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97346049
115* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96227786
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95216309
117* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95063329
118* TP63_23658742_ChIP-Seq_EP156T_Human0.94251727
119ZNF263_19887448_ChIP-Seq_K562_Human0.93154368
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.92290912
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91116985
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.90148344
123MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87810141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.94904074
2MP0003705_abnormal_hypodermis_morpholog4.78089843
3MP0005275_abnormal_skin_tensile4.54131027
4MP0005503_abnormal_tendon_morphology4.19278377
5MP0003279_aneurysm3.80085933
6MP0005623_abnormal_meninges_morphology3.16144736
7MP0004272_abnormal_basement_membrane2.89328921
8MP0003566_abnormal_cell_adhesion2.79333981
9MP0010352_gastrointestinal_tract_polyps2.72306280
10MP0001958_emphysema2.66542789
11MP0003950_abnormal_plasma_membrane2.54543346
12MP0003091_abnormal_cell_migration2.24192653
13MP0006054_spinal_hemorrhage2.09383183
14* MP0005023_abnormal_wound_healing2.08278249
15MP0009384_cardiac_valve_regurgitation2.03788374
16MP0005257_abnormal_intraocular_pressure2.02148065
17MP0005508_abnormal_skeleton_morphology2.01812055
18MP0002060_abnormal_skin_morphology1.93690505
19MP0010030_abnormal_orbit_morphology1.90812383
20MP0009780_abnormal_chondrocyte_physiolo1.89137519
21MP0009053_abnormal_anal_canal1.88332587
22MP0000733_abnormal_muscle_development1.72573456
23MP0002295_abnormal_pulmonary_circulatio1.63887533
24MP0001243_abnormal_dermal_layer1.60601079
25MP0003385_abnormal_body_wall1.60147500
26MP0005076_abnormal_cell_differentiation1.47949125
27MP0002896_abnormal_bone_mineralization1.46756545
28MP0002933_joint_inflammation1.41678937
29MP0010368_abnormal_lymphatic_system1.41454505
30MP0003283_abnormal_digestive_organ1.40202561
31MP0001348_abnormal_lacrimal_gland1.38254532
32MP0000762_abnormal_tongue_morphology1.38044128
33MP0005390_skeleton_phenotype1.37735491
34MP0002282_abnormal_trachea_morphology1.37407254
35MP0001879_abnormal_lymphatic_vessel1.34346071
36MP0009250_abnormal_appendicular_skeleto1.33704836
37MP0002877_abnormal_melanocyte_morpholog1.33099112
38* MP0000767_abnormal_smooth_muscle1.32188417
39MP0001542_abnormal_bone_strength1.31739533
40MP0002108_abnormal_muscle_morphology1.26813282
41MP0004858_abnormal_nervous_system1.25885135
42MP0003045_fibrosis1.25869848
43MP0000751_myopathy1.24043689
44MP0001299_abnormal_eye_distance/1.23577608
45MP0002932_abnormal_joint_morphology1.23270401
46MP0000428_abnormal_craniofacial_morphol1.22072440
47MP0003300_gastrointestinal_ulcer1.14997603
48MP0000163_abnormal_cartilage_morphology1.14330356
49MP0001533_abnormal_skeleton_physiology1.13853298
50MP0002115_abnormal_skeleton_extremities1.13654103
51MP0001915_intracranial_hemorrhage1.13616314
52MP0003115_abnormal_respiratory_system1.11352953
53MP0005360_urolithiasis1.10466079
54MP0004134_abnormal_chest_morphology1.07443238
55MP0001849_ear_inflammation1.01704945
56MP0005409_darkened_coat_color1.01183119
57MP0002113_abnormal_skeleton_development1.01057018
58MP0000013_abnormal_adipose_tissue1.00155022
59MP0003942_abnormal_urinary_system0.98507613
60* MP0001614_abnormal_blood_vessel0.97065656
61* MP0002168_other_aberrant_phenotype0.96432717
62MP0003191_abnormal_cellular_cholesterol0.94915209
63MP0002998_abnormal_bone_remodeling0.94681054
64MP0003755_abnormal_palate_morphology0.93272928
65MP0000534_abnormal_ureter_morphology0.92128809
66* MP0002128_abnormal_blood_circulation0.92074353
67MP0005197_abnormal_uvea_morphology0.86604023
68MP0010386_abnormal_urinary_bladder0.86128109
69MP0003448_altered_tumor_morphology0.85645592
70MP0000432_abnormal_head_morphology0.84619228
71MP0003252_abnormal_bile_duct0.84269180
72MP0000467_abnormal_esophagus_morphology0.83676833
73MP0002249_abnormal_larynx_morphology0.83582123
74MP0002697_abnormal_eye_size0.83536250
75* MP0002925_abnormal_cardiovascular_devel0.82779868
76MP0002089_abnormal_postnatal_growth/wei0.81954494
77MP0000049_abnormal_middle_ear0.81849573
78MP0003935_abnormal_craniofacial_develop0.80460161
79MP0000759_abnormal_skeletal_muscle0.78113105
80MP0000750_abnormal_muscle_regeneration0.76891772
81MP0000537_abnormal_urethra_morphology0.76205722
82MP0003795_abnormal_bone_structure0.76139617
83MP0000858_altered_metastatic_potential0.75431293
84MP0000579_abnormal_nail_morphology0.75112018
85MP0004233_abnormal_muscle_weight0.74771039
86MP0005164_abnormal_response_to0.74299817
87MP0005193_abnormal_anterior_eye0.74013973
88MP0002111_abnormal_tail_morphology0.73989196
89MP0004197_abnormal_fetal_growth/weight/0.73456017
90MP0005171_absent_coat_pigmentation0.73136542
91MP0009278_abnormal_bone_marrow0.73037490
92MP0009840_abnormal_foam_cell0.72196246
93MP0002116_abnormal_craniofacial_bone0.72009441
94MP0003937_abnormal_limbs/digits/tail_de0.71610157
95MP0002109_abnormal_limb_morphology0.70682872
96MP0005058_abnormal_lysosome_morphology0.69700279
97MP0004883_abnormal_blood_vessel0.69287159
98MP0002092_abnormal_eye_morphology0.69036349
99MP0005367_renal/urinary_system_phenotyp0.67803112
100MP0000516_abnormal_urinary_system0.67803112
101MP0005388_respiratory_system_phenotype0.67192779
102MP0002133_abnormal_respiratory_system0.67192779
103MP0001175_abnormal_lung_morphology0.67019431
104MP0000749_muscle_degeneration0.66155065
105MP0000462_abnormal_digestive_system0.62922201
106MP0000003_abnormal_adipose_tissue0.62507085
107MP0000249_abnormal_blood_vessel0.62078079
108MP0003436_decreased_susceptibility_to0.61524952
109MP0004084_abnormal_cardiac_muscle0.59397263
110MP0006138_congestive_heart_failure0.58754721
111MP0003453_abnormal_keratinocyte_physiol0.57998995
112MP0000538_abnormal_urinary_bladder0.57782733
113MP0002233_abnormal_nose_morphology0.57274622
114MP0002114_abnormal_axial_skeleton0.56245000
115MP0010771_integument_phenotype0.56025108
116MP0001661_extended_life_span0.55455891
117MP0004808_abnormal_hematopoietic_stem0.55086876
118MP0004087_abnormal_muscle_fiber0.54850165
119MP0010630_abnormal_cardiac_muscle0.54142940
120MP0005595_abnormal_vascular_smooth0.53248199
121MP0005621_abnormal_cell_physiology0.52950978
122MP0003941_abnormal_skin_development0.52752927
123MP0000569_abnormal_digit_pigmentation0.52029067
124MP0001270_distended_abdomen0.51144488
125MP0005220_abnormal_exocrine_pancreas0.50987436
126MP0002928_abnormal_bile_duct0.50912192
127MP0003868_abnormal_feces_composition0.50115819

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.02993532
2Premature rupture of membranes (HP:0001788)7.60582479
3Shallow orbits (HP:0000586)5.63858624
4Peritonitis (HP:0002586)5.43351435
5Cervical subluxation (HP:0003308)4.76145333
6Aortic dissection (HP:0002647)4.65547802
7Ankle contracture (HP:0006466)4.65309756
8Atrophic scars (HP:0001075)4.34673635
9Cerebral aneurysm (HP:0004944)4.27643522
10Broad metatarsal (HP:0001783)3.86260856
11Wrist flexion contracture (HP:0001239)3.77935527
12Soft skin (HP:0000977)3.75519489
13Fragile skin (HP:0001030)3.72268831
14Abnormality of dentin (HP:0010299)3.69579059
15Genu recurvatum (HP:0002816)3.59550112
16Dilatation of the ascending aorta (HP:0005111)3.58457863
17Bladder diverticulum (HP:0000015)3.56805214
18Mitral valve prolapse (HP:0001634)3.51458267
19Aortic aneurysm (HP:0004942)3.40808427
20Vertebral compression fractures (HP:0002953)3.31216581
21Biconcave vertebral bodies (HP:0004586)3.27878530
22Neonatal short-limb short stature (HP:0008921)3.26116227
23Blue sclerae (HP:0000592)3.21011063
24Wormian bones (HP:0002645)3.14989893
25Short nail (HP:0001799)2.85718368
26Spinal rigidity (HP:0003306)2.84720183
27Mitral stenosis (HP:0001718)2.79751874
28Abnormality of the acetabulum (HP:0003170)2.78498757
29Vascular tortuosity (HP:0004948)2.77047008
30Bowel diverticulosis (HP:0005222)2.72123830
31Follicular hyperkeratosis (HP:0007502)2.68031984
32Spondylolisthesis (HP:0003302)2.67649868
33Type 1 muscle fiber predominance (HP:0003803)2.66870401
34Distal upper limb amyotrophy (HP:0007149)2.62212820
35Upper limb amyotrophy (HP:0009129)2.62212820
36Cardiovascular calcification (HP:0011915)2.60813840
37Abnormal delivery (HP:0001787)2.60489895
38Aortic regurgitation (HP:0001659)2.58369111
39Radial bowing (HP:0002986)2.57828553
40Abnormality of the peritoneum (HP:0002585)2.53669287
41Increased connective tissue (HP:0009025)2.51448228
42Ectopia lentis (HP:0001083)2.50438932
43Aneurysm (HP:0002617)2.47263396
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.46518774
45Osteolytic defects of the hand bones (HP:0009699)2.46518774
46Elbow flexion contracture (HP:0002987)2.46197917
47Infantile muscular hypotonia (HP:0008947)2.46080297
48Tibial bowing (HP:0002982)2.44598631
49Hyperextensible skin (HP:0000974)2.40608258
50Ulnar bowing (HP:0003031)2.37513656
51Spinal cord compression (HP:0002176)2.36795214
52Camptodactyly of toe (HP:0001836)2.35785164
53Slender build (HP:0001533)2.34943388
54Deviation of the hallux (HP:0010051)2.34702887
55Increased density of long bones (HP:0006392)2.33213852
56Arterial tortuosity (HP:0005116)2.32911139
57Syringomyelia (HP:0003396)2.31199188
58Spinal cord lesions (HP:0100561)2.31199188
59Round ear (HP:0100830)2.26811152
60Bowing of the arm (HP:0006488)2.26454965
61Bowed forearm bones (HP:0003956)2.26454965
62Joint laxity (HP:0001388)2.24730805
63Broad face (HP:0000283)2.24134975
64Coxa vara (HP:0002812)2.23754211
65Abnormality of carpal bone ossification (HP:0006257)2.22765813
66Hallux valgus (HP:0001822)2.19554310
67Hand muscle atrophy (HP:0009130)2.17736745
68Aortic valve stenosis (HP:0001650)2.16124338
69Thin bony cortex (HP:0002753)2.16119609
70Renal duplication (HP:0000075)2.15228296
71Ovoid vertebral bodies (HP:0003300)2.14841965
72Abnormality of the calcaneus (HP:0008364)2.12611904
73Natal tooth (HP:0000695)2.12325889
74Wide anterior fontanel (HP:0000260)2.12258446
75Mesomelia (HP:0003027)2.11821156
76Hypoventilation (HP:0002791)2.10946713
77Overgrowth (HP:0001548)2.08167113
78Increased variability in muscle fiber diameter (HP:0003557)2.07347619
79Broad long bones (HP:0005622)2.05053645
80Femoral bowing (HP:0002980)2.04343486
81Coronal craniosynostosis (HP:0004440)2.03671220
82Mild short stature (HP:0003502)2.03035997
83Abnormal ossification of hand bones (HP:0005921)2.02586903
84Cupped ribs (HP:0000887)2.01217377
85Beaking of vertebral bodies (HP:0004568)2.00622641
86Delayed closure of the anterior fontanelle (HP:0001476)1.98843724
87Nonimmune hydrops fetalis (HP:0001790)1.98716515
88Deep venous thrombosis (HP:0002625)1.98515464
89Joint stiffness (HP:0001387)1.98333225
90Buphthalmos (HP:0000557)1.97491655
91Breech presentation (HP:0001623)1.96768657
92Generalized amyotrophy (HP:0003700)1.95703339
93Increased mean platelet volume (HP:0011877)1.95564850
94Mildly elevated creatine phosphokinase (HP:0008180)1.95037577
95Flat acetabular roof (HP:0003180)1.94742882
96Flared iliac wings (HP:0002869)1.94321903
97Protruding ear (HP:0000411)1.94259631
98Mitral regurgitation (HP:0001653)1.92040430
99Platyspondyly (HP:0000926)1.91992053
100Osteoarthritis (HP:0002758)1.91402338
101Abnormality of the odontoid process (HP:0003310)1.88552074
102Fused cervical vertebrae (HP:0002949)1.87413868
103Knee flexion contracture (HP:0006380)1.86760129
104Turricephaly (HP:0000262)1.86726110
105Broad ribs (HP:0000885)1.86007839
106Joint contractures involving the joints of the feet (HP:0100492)1.85899011
107Flexion contracture of toe (HP:0005830)1.85899011
108Disproportionate tall stature (HP:0001519)1.84927720
109Bronchomalacia (HP:0002780)1.84129762
110Short 4th metacarpal (HP:0010044)1.83790643
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83790643
112Systemic lupus erythematosus (HP:0002725)1.81544936
113Absent frontal sinuses (HP:0002688)1.81254679
114Pterygium (HP:0001059)1.80680301
115Abnormality of skeletal muscle fiber size (HP:0012084)1.80588576
116Achilles tendon contracture (HP:0001771)1.78695882
117Tarsal synostosis (HP:0008368)1.77548470
118Congenital glaucoma (HP:0001087)1.76997818
119Hypoplasia of the iris (HP:0007676)1.75435111
120Inguinal hernia (HP:0000023)1.74794199
121Delayed cranial suture closure (HP:0000270)1.72709795
122Abnormality of the Achilles tendon (HP:0005109)1.72082899
123Thin skin (HP:0000963)1.72038112
124Striae distensae (HP:0001065)1.71322282
125Abnormality of skull ossification (HP:0002703)1.69642327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.58887254
2TRIB34.32269563
3DDR24.21169774
4ERN13.56698235
5MYLK3.42405550
6PKN23.37978404
7PDGFRA2.95810005
8LATS22.67120208
9LATS12.61475474
10EPHA22.55781309
11BMX2.50522741
12RIPK12.47925605
13SIK12.35012316
14EPHB22.10887582
15PTK22.04200977
16PAK21.96344827
17PTK61.90816308
18MET1.78439447
19CDK121.70510806
20MST1R1.64291760
21EEF2K1.61696860
22LRRK21.60564001
23TRPM71.53070539
24CAMK1D1.52376168
25PAK41.51150797
26MAP3K101.48852086
27AKT31.42702796
28STK31.29157271
29MTOR1.28181476
30PAK31.25258925
31MOS1.24553395
32FGFR11.24421028
33ARAF1.18984548
34TGFBR21.18477414
35PTK2B1.17366837
36STK101.14730020
37FER1.14411265
38LMTK21.09293618
39CAMK1G1.08960928
40PDGFRB1.05015418
41RPS6KA41.03404991
42EPHB11.02344042
43WNK10.98489601
44IRAK30.96170899
45MAP3K60.92557257
46DMPK0.90779780
47KSR20.88678267
48TESK10.83926124
49ROCK10.82905535
50ILK0.82482215
51PIM20.77600064
52EPHA30.76449940
53NEK90.76308343
54SCYL20.74381875
55FGFR30.73891160
56CDK60.72765236
57ABL20.72106969
58NTRK10.71174715
59ROCK20.69127425
60LIMK10.66412979
61STK38L0.66098318
62MAP2K30.65886867
63PRKCH0.65848046
64INSR0.65252957
65FLT30.63258989
66ICK0.62252189
67TIE10.61951935
68CAMKK10.60365496
69MELK0.59994299
70GSK3A0.58846679
71ERBB40.58622170
72MAP3K20.56416185
73MAP3K80.55569665
74PAK10.55482269
75KIT0.54658024
76MAPK70.52772628
77SMG10.51736809
78ADRBK10.51690146
79MAP2K10.50348373
80RET0.49984122
81PIK3CG0.49231224
82JAK10.49187212
83FGFR40.49059790
84DAPK30.49005216
85PIK3CA0.47075748
86TAOK20.45936058
87MAP3K30.44943393
88PRKD20.44458102
89CDK80.44356152
90PAK60.43730714
91SRC0.43666717
92DYRK1B0.43125173
93STK380.41649776
94MAP3K130.41587707
95PRKG20.41374940
96CLK10.40009792
97PRKD10.38784573
98JAK30.38688798
99ZAP700.38603993
100RPS6KA20.38514424
101MAPK10.36399583
102HCK0.35681791
103RAF10.35311132
104WNK40.35177021
105CSK0.35072614
106TBK10.34800163
107PRKD30.34198737
108BLK0.34054301
109EGFR0.33891354
110TESK20.33512832
111MAPKAPK30.32591683
112TYRO30.32290884
113IGF1R0.32241030
114MAPKAPK20.32197126
115CSF1R0.31933557
116TGFBR10.30799703
117MAPK110.30370272
118CHUK0.29472986
119NEK20.29374866
120PLK20.29357543
121CDC42BPA0.29239497
122PRKCE0.29194304
123MAP3K120.29179792
124RPS6KB20.29070732
125KDR0.28015662
126RPS6KC10.27763087
127RPS6KL10.27763087
128MAP3K70.26118786
129CDK70.26006672

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045123.92599769
2* Focal adhesion_Homo sapiens_hsa045102.94981169
3Staphylococcus aureus infection_Homo sapiens_hsa051502.66992019
4Complement and coagulation cascades_Homo sapiens_hsa046102.55087336
5* Proteoglycans in cancer_Homo sapiens_hsa052052.34447136
6* Amoebiasis_Homo sapiens_hsa051462.33254891
7Adherens junction_Homo sapiens_hsa045202.29091330
8Malaria_Homo sapiens_hsa051442.25417630
9Bladder cancer_Homo sapiens_hsa052192.21214500
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.17687312
11* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.93151239
12Protein digestion and absorption_Homo sapiens_hsa049741.89594143
13* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.81854416
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.74846127
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71655891
16MicroRNAs in cancer_Homo sapiens_hsa052061.69739930
17Hippo signaling pathway_Homo sapiens_hsa043901.67492063
18TGF-beta signaling pathway_Homo sapiens_hsa043501.66445998
19* Small cell lung cancer_Homo sapiens_hsa052221.64235284
20Chronic myeloid leukemia_Homo sapiens_hsa052201.58387386
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.52530809
22Other glycan degradation_Homo sapiens_hsa005111.51966336
23Basal cell carcinoma_Homo sapiens_hsa052171.47142010
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.44311379
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44056369
26* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.39259734
27Nitrogen metabolism_Homo sapiens_hsa009101.36804332
28Dilated cardiomyopathy_Homo sapiens_hsa054141.36129419
29* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.34554322
30Shigellosis_Homo sapiens_hsa051311.30477859
31p53 signaling pathway_Homo sapiens_hsa041151.28939201
32N-Glycan biosynthesis_Homo sapiens_hsa005101.19638187
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18305756
34Caffeine metabolism_Homo sapiens_hsa002321.17936656
35Pertussis_Homo sapiens_hsa051331.17321786
36Melanoma_Homo sapiens_hsa052181.15315289
37Platelet activation_Homo sapiens_hsa046111.12391595
38Phagosome_Homo sapiens_hsa041451.06983082
39Leishmaniasis_Homo sapiens_hsa051401.05341794
40Hedgehog signaling pathway_Homo sapiens_hsa043401.03925056
41Pancreatic cancer_Homo sapiens_hsa052121.02418239
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01949228
43Prion diseases_Homo sapiens_hsa050201.01859982
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00915912
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97304140
46Toxoplasmosis_Homo sapiens_hsa051450.96584291
47Lysosome_Homo sapiens_hsa041420.96497270
48Rap1 signaling pathway_Homo sapiens_hsa040150.95565576
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93838686
50Thyroid cancer_Homo sapiens_hsa052160.91827879
51Prostate cancer_Homo sapiens_hsa052150.91157182
52Viral myocarditis_Homo sapiens_hsa054160.90212690
53Vibrio cholerae infection_Homo sapiens_hsa051100.89838683
54Salmonella infection_Homo sapiens_hsa051320.88574438
55* Pathways in cancer_Homo sapiens_hsa052000.87989316
56Lysine degradation_Homo sapiens_hsa003100.85776551
57HTLV-I infection_Homo sapiens_hsa051660.85766894
58Glioma_Homo sapiens_hsa052140.84065091
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84045683
60TNF signaling pathway_Homo sapiens_hsa046680.83811289
61Tight junction_Homo sapiens_hsa045300.83733371
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.81785920
63Galactose metabolism_Homo sapiens_hsa000520.81555202
64Gap junction_Homo sapiens_hsa045400.80443558
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77525870
66Thyroid hormone synthesis_Homo sapiens_hsa049180.77214573
67Notch signaling pathway_Homo sapiens_hsa043300.76617149
68One carbon pool by folate_Homo sapiens_hsa006700.75387003
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75363677
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.72482295
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71719520
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.70749160
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69317594
74Apoptosis_Homo sapiens_hsa042100.67374815
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67226949
76Arginine biosynthesis_Homo sapiens_hsa002200.66801778
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64503307
78mTOR signaling pathway_Homo sapiens_hsa041500.63087790
79Hepatitis B_Homo sapiens_hsa051610.61801137
80Colorectal cancer_Homo sapiens_hsa052100.60894756
81Wnt signaling pathway_Homo sapiens_hsa043100.58549370
82Viral carcinogenesis_Homo sapiens_hsa052030.58447888
83Renal cell carcinoma_Homo sapiens_hsa052110.57956159
84HIF-1 signaling pathway_Homo sapiens_hsa040660.57908550
85Sphingolipid metabolism_Homo sapiens_hsa006000.57662828
86Insulin resistance_Homo sapiens_hsa049310.56052930
87Renin-angiotensin system_Homo sapiens_hsa046140.55984185
88Axon guidance_Homo sapiens_hsa043600.55804578
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53853924
90Tuberculosis_Homo sapiens_hsa051520.53742005
91Osteoclast differentiation_Homo sapiens_hsa043800.53457153
92GnRH signaling pathway_Homo sapiens_hsa049120.52683025
93Melanogenesis_Homo sapiens_hsa049160.50524653
94ErbB signaling pathway_Homo sapiens_hsa040120.49714784
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49539469
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.49411575
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48739907
98Ras signaling pathway_Homo sapiens_hsa040140.48329797
99PPAR signaling pathway_Homo sapiens_hsa033200.47098522
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46812704
101Bile secretion_Homo sapiens_hsa049760.46544867
102Acute myeloid leukemia_Homo sapiens_hsa052210.46230548
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.45387442
104Endometrial cancer_Homo sapiens_hsa052130.44334669
105Estrogen signaling pathway_Homo sapiens_hsa049150.42664055
106FoxO signaling pathway_Homo sapiens_hsa040680.42431918
107Legionellosis_Homo sapiens_hsa051340.42243443
108Endocytosis_Homo sapiens_hsa041440.41387936
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40953908
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.40897102
111Sulfur metabolism_Homo sapiens_hsa009200.40696740
112Non-small cell lung cancer_Homo sapiens_hsa052230.40097736
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39437432
114VEGF signaling pathway_Homo sapiens_hsa043700.38930410
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38731876
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37112285
117Dorso-ventral axis formation_Homo sapiens_hsa043200.37027134
118AMPK signaling pathway_Homo sapiens_hsa041520.36991531
119Chemical carcinogenesis_Homo sapiens_hsa052040.35916661
120Tryptophan metabolism_Homo sapiens_hsa003800.35844075
121MAPK signaling pathway_Homo sapiens_hsa040100.35466244
122Pentose phosphate pathway_Homo sapiens_hsa000300.35449315
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.34724949
124Selenocompound metabolism_Homo sapiens_hsa004500.34711256
125Starch and sucrose metabolism_Homo sapiens_hsa005000.31155303
126Glucagon signaling pathway_Homo sapiens_hsa049220.30579296
127Choline metabolism in cancer_Homo sapiens_hsa052310.30357616

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