FN3K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way, fructosamines, are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of fructosamines which may result in deglycation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)3.96653596
2behavioral response to nicotine (GO:0035095)3.88545229
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.87703712
4L-phenylalanine catabolic process (GO:0006559)3.87703712
5neuronal action potential propagation (GO:0019227)3.76720617
6regulation of short-term neuronal synaptic plasticity (GO:0048172)3.65774089
7positive regulation of synapse maturation (GO:0090129)3.62207854
8vocalization behavior (GO:0071625)3.56785789
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.54900575
10central nervous system myelination (GO:0022010)3.54757866
11axon ensheathment in central nervous system (GO:0032291)3.54757866
12L-phenylalanine metabolic process (GO:0006558)3.53324504
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.53324504
14glutamate secretion (GO:0014047)3.45607700
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.40357830
16response to methylmercury (GO:0051597)3.40132057
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.39757963
18neuron cell-cell adhesion (GO:0007158)3.37605663
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36534307
20membrane depolarization during action potential (GO:0086010)3.34666509
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31901154
22regulation of synapse maturation (GO:0090128)3.30704599
23regulation of synaptic vesicle exocytosis (GO:2000300)3.30282219
24gamma-aminobutyric acid transport (GO:0015812)3.24735606
25dendritic spine morphogenesis (GO:0060997)3.22570617
26behavioral response to cocaine (GO:0048148)3.19443197
27protein localization to synapse (GO:0035418)3.18153125
28presynaptic membrane organization (GO:0097090)3.16399450
29synaptic vesicle maturation (GO:0016188)3.10962866
30presynaptic membrane assembly (GO:0097105)3.09970381
31neurotransmitter secretion (GO:0007269)3.09137179
32neurotransmitter-gated ion channel clustering (GO:0072578)3.08157549
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08009531
34fatty acid elongation (GO:0030497)3.07999448
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07996939
36regulation of glutamate receptor signaling pathway (GO:1900449)3.06776176
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05548579
38neuron-neuron synaptic transmission (GO:0007270)3.05295695
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.04495363
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04456806
41cellular ketone body metabolic process (GO:0046950)3.03346787
42proline transport (GO:0015824)3.00159803
43potassium ion homeostasis (GO:0055075)2.99640885
44potassium ion import (GO:0010107)2.98624243
45regulation of synaptic vesicle transport (GO:1902803)2.98422753
46ionotropic glutamate receptor signaling pathway (GO:0035235)2.98280454
47auditory behavior (GO:0031223)2.97819633
48respiratory electron transport chain (GO:0022904)2.95747644
49locomotory exploration behavior (GO:0035641)2.92878361
50ATP synthesis coupled proton transport (GO:0015986)2.92244296
51energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92244296
52regulation of synapse structural plasticity (GO:0051823)2.91850170
53dicarboxylic acid catabolic process (GO:0043649)2.91606039
54C4-dicarboxylate transport (GO:0015740)2.91447480
55glutamate receptor signaling pathway (GO:0007215)2.90952551
56sodium ion export (GO:0071436)2.90743713
57exogenous drug catabolic process (GO:0042738)2.90531325
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90178981
59electron transport chain (GO:0022900)2.88776016
60primary amino compound metabolic process (GO:1901160)2.87699305
61neuromuscular process controlling posture (GO:0050884)2.86442475
62synaptic transmission, glutamatergic (GO:0035249)2.84736430
63ATP hydrolysis coupled proton transport (GO:0015991)2.82925146
64energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82925146
65neuromuscular synaptic transmission (GO:0007274)2.81582929
66neuronal ion channel clustering (GO:0045161)2.81395080
67aromatic amino acid family catabolic process (GO:0009074)2.78992367
68neurotransmitter transport (GO:0006836)2.78581212
69negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77933646
70pyrimidine nucleobase catabolic process (GO:0006208)2.74302229
71drug catabolic process (GO:0042737)2.74060708
72cell migration in hindbrain (GO:0021535)2.73350995
73protoporphyrinogen IX metabolic process (GO:0046501)2.71817548
74positive regulation of dendritic spine development (GO:0060999)2.70973898
75aspartate family amino acid catabolic process (GO:0009068)2.70081900
76alanine transport (GO:0032328)2.70077379
77cellular sodium ion homeostasis (GO:0006883)2.69744034
78NADH metabolic process (GO:0006734)2.67267021
79regulation of neurotransmitter secretion (GO:0046928)2.66825491
80regulation of neuronal synaptic plasticity (GO:0048168)2.66702690
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66361775
82regulation of neurotransmitter transport (GO:0051588)2.66196342
83coenzyme catabolic process (GO:0009109)2.65287369
84glyoxylate metabolic process (GO:0046487)2.64434313
85membrane depolarization (GO:0051899)2.63522804
86regulation of catecholamine metabolic process (GO:0042069)2.63086994
87regulation of dopamine metabolic process (GO:0042053)2.63086994
88succinate metabolic process (GO:0006105)2.62573808
89regulation of neurotransmitter levels (GO:0001505)2.62551543
90detection of calcium ion (GO:0005513)2.62254035
91ketone body metabolic process (GO:1902224)2.62246250
92calcium-mediated signaling using intracellular calcium source (GO:0035584)2.62157906
93serotonin metabolic process (GO:0042428)2.62137731
94regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60699027
95nucleobase catabolic process (GO:0046113)2.60038073
96transmission of nerve impulse (GO:0019226)2.59638385
97synaptic vesicle docking involved in exocytosis (GO:0016081)2.58823448
98protoporphyrinogen IX biosynthetic process (GO:0006782)2.58768317
99regulation of long-term neuronal synaptic plasticity (GO:0048169)2.58406088
100regulation of sodium ion transmembrane transporter activity (GO:2000649)2.57898730
101auditory receptor cell stereocilium organization (GO:0060088)2.56518319
102regulation of glutamate secretion (GO:0014048)2.56460501
103long-term synaptic potentiation (GO:0060291)2.56110611
104neuron recognition (GO:0008038)2.55054816
105glycine transport (GO:0015816)2.53962428
106glutamate metabolic process (GO:0006536)2.53788261
107negative regulation of neurotransmitter transport (GO:0051589)2.53068544
108regulation of membrane repolarization (GO:0060306)2.52545127
109cerebellar Purkinje cell differentiation (GO:0021702)2.51903813
110regulation of voltage-gated calcium channel activity (GO:1901385)2.50238548
111regulation of postsynaptic membrane potential (GO:0060078)2.50106892
112adult walking behavior (GO:0007628)2.49975846
113neurotransmitter uptake (GO:0001504)2.49848652
114cell communication by electrical coupling (GO:0010644)2.49240581
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48910508
116regulation of neurotransmitter uptake (GO:0051580)2.48668564
117positive regulation of sodium ion transmembrane transport (GO:1902307)2.48581619
118synaptic vesicle endocytosis (GO:0048488)2.48418392
119neuronal action potential (GO:0019228)2.48218400
120cerebellar granule cell differentiation (GO:0021707)2.44531421
121cellular potassium ion homeostasis (GO:0030007)2.44367429
122detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44180004
123regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43912496
124glycosphingolipid biosynthetic process (GO:0006688)2.43817326
125synaptic transmission (GO:0007268)2.43774826
126regulation of vesicle fusion (GO:0031338)2.43668501
127peroxisome fission (GO:0016559)2.42921212
128glycerophospholipid catabolic process (GO:0046475)2.42899148
129membrane repolarization (GO:0086009)2.41971305
130regulation of sodium ion transmembrane transport (GO:1902305)2.41904250
131female mating behavior (GO:0060180)2.41897056
132long-term memory (GO:0007616)2.40893574
133regulation of synaptic transmission, glutamatergic (GO:0051966)2.40523428
134transferrin transport (GO:0033572)2.39850721
135chaperone-mediated protein transport (GO:0072321)2.39616782
136positive regulation of membrane potential (GO:0045838)2.39012480
137phosphorelay signal transduction system (GO:0000160)2.38589517
138multicellular organismal signaling (GO:0035637)2.38317855
139adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.38204811
140negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37598215
141striatum development (GO:0021756)2.36463675
142response to insecticide (GO:0017085)2.33533155
143synaptic transmission, dopaminergic (GO:0001963)2.31802400
144regulation of oxidative phosphorylation (GO:0002082)2.29961916
145regulation of synaptic plasticity (GO:0048167)2.28626365
146postsynaptic membrane organization (GO:0001941)2.28442178
147exploration behavior (GO:0035640)2.27502275
148ferric iron transport (GO:0015682)2.27375102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63778526
2GBX2_23144817_ChIP-Seq_PC3_Human3.70246519
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76052734
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75546607
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46733291
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.36391165
7TAF15_26573619_Chip-Seq_HEK293_Human2.34745360
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24872386
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24104314
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23810604
11REST_21632747_ChIP-Seq_MESCs_Mouse2.23506430
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22554191
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18780342
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18780342
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16882345
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10204201
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.02446620
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.02230138
19RARB_27405468_Chip-Seq_BRAIN_Mouse1.97716913
20REST_18959480_ChIP-ChIP_MESCs_Mouse1.92919826
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92642423
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.89111571
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81103804
24DROSHA_22980978_ChIP-Seq_HELA_Human1.80094046
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79034393
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77684181
27* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74615709
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72620468
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72473641
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69751554
31AR_21572438_ChIP-Seq_LNCaP_Human1.69617314
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69521519
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69020572
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66251627
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66182160
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66103079
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61350379
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.59543727
39* RXR_22158963_ChIP-Seq_LIVER_Mouse1.56648584
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55117514
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53187483
42SMAD4_21799915_ChIP-Seq_A2780_Human1.52269132
43P300_19829295_ChIP-Seq_ESCs_Human1.49961676
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.47269685
45VDR_22108803_ChIP-Seq_LS180_Human1.44771135
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43440775
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35717708
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.35606869
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35206749
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.34444048
51CTCF_27219007_Chip-Seq_Bcells_Human1.28907706
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.28106375
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28043650
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27021959
55RNF2_27304074_Chip-Seq_NSC_Mouse1.26367664
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24363366
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22487627
58HTT_18923047_ChIP-ChIP_STHdh_Human1.22369549
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22030865
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21669773
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21499132
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.19752186
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19414610
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15179103
65AR_25329375_ChIP-Seq_VCAP_Human1.15092599
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14788020
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12730141
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11717284
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.10444460
70ERA_21632823_ChIP-Seq_H3396_Human1.09771505
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07900742
72STAT3_23295773_ChIP-Seq_U87_Human1.07588014
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07452151
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06724698
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06210417
76ER_23166858_ChIP-Seq_MCF-7_Human1.05315355
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05030959
78OCT4_20526341_ChIP-Seq_ESCs_Human1.04668129
79* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04306500
80OCT4_19829295_ChIP-Seq_ESCs_Human1.02734300
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01789494
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01337181
83CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99341417
84MYC_19829295_ChIP-Seq_ESCs_Human0.99292620
85DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99250222
86* TCF4_23295773_ChIP-Seq_U87_Human0.98898673
87FUS_26573619_Chip-Seq_HEK293_Human0.98658737
88ZNF274_21170338_ChIP-Seq_K562_Hela0.97380673
89IGF1R_20145208_ChIP-Seq_DFB_Human0.95497562
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95402390
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95402390
92TP53_22573176_ChIP-Seq_HFKS_Human0.94790340
93P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94241947
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93944190
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93816433
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92189727
97* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91240181
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90817886
99RING1B_27294783_Chip-Seq_ESCs_Mouse0.90698572
100P68_20966046_ChIP-Seq_HELA_Human0.89538911
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.88890446
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88451057
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88243907
104AR_19668381_ChIP-Seq_PC3_Human0.87716209
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.87513185
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86931939
107TAF2_19829295_ChIP-Seq_ESCs_Human0.86741308
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86724552
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86724552
110NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86623765
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86611088
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.86470680
113FOXH1_21741376_ChIP-Seq_ESCs_Human0.86282366
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86127762
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85533736
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85445966
117CTCF_20526341_ChIP-Seq_ESCs_Human0.85350922
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.85272658
119RUNX2_22187159_ChIP-Seq_PCA_Human0.85123899
120KDM2B_26808549_Chip-Seq_REH_Human0.84692498
121* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84549753
122BCAT_22108803_ChIP-Seq_LS180_Human0.83546492
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82967739
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.82732816
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82278882
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82174608
127KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81946539
128GATA3_21878914_ChIP-Seq_MCF-7_Human0.81944549
129* NCOR_22424771_ChIP-Seq_293T_Human0.80914356
130NANOG_19829295_ChIP-Seq_ESCs_Human0.80190810
131SOX2_19829295_ChIP-Seq_ESCs_Human0.80190810
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.79457375
133KLF4_19829295_ChIP-Seq_ESCs_Human0.78685906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.58822946
2MP0004859_abnormal_synaptic_plasticity3.96951413
3MP0003635_abnormal_synaptic_transmissio3.01989266
4MP0009745_abnormal_behavioral_response2.81658724
5MP0002064_seizures2.76169095
6MP0002837_dystrophic_cardiac_calcinosis2.67932245
7MP0009046_muscle_twitch2.61668095
8MP0004270_analgesia2.60083788
9MP0002139_abnormal_hepatobiliary_system2.49564382
10MP0002822_catalepsy2.46939887
11MP0002272_abnormal_nervous_system2.44301247
12MP0001968_abnormal_touch/_nociception2.42467375
13MP0002063_abnormal_learning/memory/cond2.39147034
14MP0001529_abnormal_vocalization2.33030568
15MP0002736_abnormal_nociception_after2.24655846
16MP0005360_urolithiasis2.22755561
17MP0002572_abnormal_emotion/affect_behav2.19191809
18MP0005085_abnormal_gallbladder_physiolo2.13375474
19MP0001486_abnormal_startle_reflex2.11608545
20MP0003329_amyloid_beta_deposits2.00544766
21MP0008875_abnormal_xenobiotic_pharmacok1.99263303
22MP0004043_abnormal_pH_regulation1.99057620
23MP0002734_abnormal_mechanical_nocicepti1.96041872
24MP0001501_abnormal_sleep_pattern1.92957362
25MP0005423_abnormal_somatic_nervous1.89376137
26MP0001986_abnormal_taste_sensitivity1.86849791
27MP0001440_abnormal_grooming_behavior1.85534063
28MP0003787_abnormal_imprinting1.83287510
29MP0004142_abnormal_muscle_tone1.81949450
30MP0003656_abnormal_erythrocyte_physiolo1.77234560
31MP0005646_abnormal_pituitary_gland1.76004267
32MP0005365_abnormal_bile_salt1.75974127
33MP0002067_abnormal_sensory_capabilities1.74559139
34MP0004147_increased_porphyrin_level1.69644676
35MP0003195_calcinosis1.64408255
36MP0002638_abnormal_pupillary_reflex1.61209139
37MP0001905_abnormal_dopamine_level1.59224638
38MP0006276_abnormal_autonomic_nervous1.57504939
39MP0002735_abnormal_chemical_nociception1.56648549
40MP0004924_abnormal_behavior1.54929769
41MP0005386_behavior/neurological_phenoty1.54929769
42MP0005083_abnormal_biliary_tract1.53223414
43MP0001970_abnormal_pain_threshold1.51043979
44MP0005551_abnormal_eye_electrophysiolog1.50425195
45MP0009780_abnormal_chondrocyte_physiolo1.48344025
46MP0000920_abnormal_myelination1.47822449
47MP0002733_abnormal_thermal_nociception1.46083057
48MP0008569_lethality_at_weaning1.42949267
49MP0003690_abnormal_glial_cell1.34993556
50MP0001984_abnormal_olfaction1.34588280
51MP0008872_abnormal_physiological_respon1.33861501
52MP0003633_abnormal_nervous_system1.30163702
53MP0003123_paternal_imprinting1.29797954
54MP0002653_abnormal_ependyma_morphology1.29270608
55MP0005535_abnormal_body_temperature1.28213689
56MP0003879_abnormal_hair_cell1.28113540
57MP0002229_neurodegeneration1.26410908
58MP0006036_abnormal_mitochondrial_physio1.24654951
59MP0000751_myopathy1.23554898
60MP0002909_abnormal_adrenal_gland1.22570021
61MP0002066_abnormal_motor_capabilities/c1.21858739
62MP0003878_abnormal_ear_physiology1.21519280
63MP0005377_hearing/vestibular/ear_phenot1.21519280
64MP0002557_abnormal_social/conspecific_i1.21251267
65MP0001502_abnormal_circadian_rhythm1.15841539
66MP0005332_abnormal_amino_acid1.14645551
67MP0001485_abnormal_pinna_reflex1.10690781
68MP0003631_nervous_system_phenotype1.10441811
69MP0004145_abnormal_muscle_electrophysio1.10371620
70MP0005167_abnormal_blood-brain_barrier1.09840968
71MP0004885_abnormal_endolymph1.09734492
72MP0004215_abnormal_myocardial_fiber1.09145510
73MP0010329_abnormal_lipoprotein_level1.08866246
74MP0002184_abnormal_innervation1.07706637
75MP0006292_abnormal_olfactory_placode1.07583501
76MP0002882_abnormal_neuron_morphology1.06839750
77MP0000955_abnormal_spinal_cord1.05917987
78MP0000604_amyloidosis1.05762468
79MP0000778_abnormal_nervous_system1.05373656
80MP0000013_abnormal_adipose_tissue1.04682406
81MP0008877_abnormal_DNA_methylation1.04279555
82MP0003806_abnormal_nucleotide_metabolis1.03918671
83MP0001963_abnormal_hearing_physiology1.03564965
84MP0002876_abnormal_thyroid_physiology1.01304712
85MP0004085_abnormal_heartbeat0.99837503
86MP0003136_yellow_coat_color0.99597939
87MP0004811_abnormal_neuron_physiology0.98109769
88MP0008874_decreased_physiological_sensi0.96122380
89MP0004036_abnormal_muscle_relaxation0.95960671
90MP0003122_maternal_imprinting0.94501467
91MP0010386_abnormal_urinary_bladder0.94266488
92MP0003646_muscle_fatigue0.92938727
93MP0002118_abnormal_lipid_homeostasis0.92804111
94MP0002090_abnormal_vision0.91870910
95MP0006035_abnormal_mitochondrial_morpho0.89343384
96MP0003121_genomic_imprinting0.88440076
97MP0003634_abnormal_glial_cell0.88151181
98MP0004133_heterotaxia0.87652479
99MP0003011_delayed_dark_adaptation0.86204681
100MP0005584_abnormal_enzyme/coenzyme_acti0.86159053
101MP0001666_abnormal_nutrient_absorption0.82879558
102MP0000631_abnormal_neuroendocrine_gland0.82539807
103MP0002069_abnormal_eating/drinking_beha0.82134028
104MP0004742_abnormal_vestibular_system0.81871570
105MP0000749_muscle_degeneration0.81634597
106MP0000566_synostosis0.81559017
107MP0000747_muscle_weakness0.80650822
108MP0002752_abnormal_somatic_nervous0.80109383
109MP0003632_abnormal_nervous_system0.79040530
110MP0008775_abnormal_heart_ventricle0.78622386
111MP0005645_abnormal_hypothalamus_physiol0.78568712
112MP0001765_abnormal_ion_homeostasis0.78494282
113MP0000026_abnormal_inner_ear0.78471661
114MP0004130_abnormal_muscle_cell0.78390030
115MP0005253_abnormal_eye_physiology0.77907204
116MP0005636_abnormal_mineral_homeostasis0.77424443
117MP0003137_abnormal_impulse_conducting0.77376973
118MP0002152_abnormal_brain_morphology0.77133855
119MP0005670_abnormal_white_adipose0.75596139
120MP0003868_abnormal_feces_composition0.71277522
121MP0003252_abnormal_bile_duct0.70665499
122MP0005171_absent_coat_pigmentation0.70652968
123MP0005448_abnormal_energy_balance0.70307636
124MP0009840_abnormal_foam_cell0.70259648
125MP0005379_endocrine/exocrine_gland_phen0.69866190
126MP0002078_abnormal_glucose_homeostasis0.69623167

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.72974558
2Myokymia (HP:0002411)4.22724764
3Focal seizures (HP:0007359)3.73858600
4Epileptic encephalopathy (HP:0200134)3.72218335
5Acute necrotizing encephalopathy (HP:0006965)3.63514697
6Visual hallucinations (HP:0002367)3.50888199
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.50107612
8Limb dystonia (HP:0002451)3.49054586
9Abnormal mitochondria in muscle tissue (HP:0008316)3.48226593
10Acute encephalopathy (HP:0006846)3.46310687
11Hyperventilation (HP:0002883)3.42411259
12Atonic seizures (HP:0010819)3.42083962
13Pheochromocytoma (HP:0002666)3.19214651
14Generalized tonic-clonic seizures (HP:0002069)3.18588717
15Absence seizures (HP:0002121)3.18460327
16Progressive macrocephaly (HP:0004481)3.15539958
17Abnormal gallbladder physiology (HP:0012438)3.12042023
18Cholecystitis (HP:0001082)3.12042023
19Febrile seizures (HP:0002373)3.06383582
20Neurofibrillary tangles (HP:0002185)3.05532977
21Dialeptic seizures (HP:0011146)3.03827872
22Cerebral edema (HP:0002181)2.94410150
23Hemiparesis (HP:0001269)2.91819308
24Cerebral inclusion bodies (HP:0100314)2.91509588
25Mitochondrial inheritance (HP:0001427)2.91454892
26Abnormality of binocular vision (HP:0011514)2.89014739
27Diplopia (HP:0000651)2.89014739
28Abnormal gallbladder morphology (HP:0012437)2.88148121
29Cholelithiasis (HP:0001081)2.86592802
30Congenital stationary night blindness (HP:0007642)2.86068888
31Anxiety (HP:0000739)2.83616837
32Neuroendocrine neoplasm (HP:0100634)2.82627812
33Polyphagia (HP:0002591)2.64356539
34Abnormal drinking behavior (HP:0030082)2.59706627
35Polydipsia (HP:0001959)2.59706627
36Type II lissencephaly (HP:0007260)2.57279757
37Hepatocellular necrosis (HP:0001404)2.55892414
38Dysmetria (HP:0001310)2.53255121
39Leukodystrophy (HP:0002415)2.53136712
40Progressive cerebellar ataxia (HP:0002073)2.51837179
41Increased CSF lactate (HP:0002490)2.51241949
42Ketosis (HP:0001946)2.48046167
43Status epilepticus (HP:0002133)2.45430607
44Poikilocytosis (HP:0004447)2.44692035
45Amblyopia (HP:0000646)2.42660458
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42254539
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.42254539
48Dysdiadochokinesis (HP:0002075)2.41755043
49Supranuclear gaze palsy (HP:0000605)2.39004457
50Scanning speech (HP:0002168)2.37488033
51Cerebral hypomyelination (HP:0006808)2.36241674
52Hyperglycinuria (HP:0003108)2.32466601
53Ketoacidosis (HP:0001993)2.31874149
54Optic disc pallor (HP:0000543)2.30164027
55Epileptiform EEG discharges (HP:0011182)2.27629376
56Depression (HP:0000716)2.27489707
57Hepatic necrosis (HP:0002605)2.27104000
58Abnormality of the heme biosynthetic pathway (HP:0010472)2.27087531
59Hyperlipoproteinemia (HP:0010980)2.26240750
60Intrahepatic cholestasis (HP:0001406)2.24102016
61Nephronophthisis (HP:0000090)2.23076378
62Delusions (HP:0000746)2.20711165
63EEG with generalized epileptiform discharges (HP:0011198)2.18964357
64Abnormality of the corticospinal tract (HP:0002492)2.18839758
65Abnormality of glycolysis (HP:0004366)2.17633985
66Increased serum pyruvate (HP:0003542)2.17633985
67Acanthocytosis (HP:0001927)2.16614752
68Action tremor (HP:0002345)2.16210796
69Hypochromic microcytic anemia (HP:0004840)2.16089039
70Abnormal social behavior (HP:0012433)2.15445309
71Impaired social interactions (HP:0000735)2.15445309
72Pancreatic cysts (HP:0001737)2.14201915
73Genetic anticipation (HP:0003743)2.13942862
74Exercise-induced myalgia (HP:0003738)2.12899518
75Poor eye contact (HP:0000817)2.12383945
76Pancreatic fibrosis (HP:0100732)2.12193721
77Progressive inability to walk (HP:0002505)2.11957738
78Abnormality of the renal cortex (HP:0011035)2.11536874
79Abnormality of alanine metabolism (HP:0010916)2.11345138
80Hyperalaninemia (HP:0003348)2.11345138
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11345138
82Urinary bladder sphincter dysfunction (HP:0002839)2.10462465
83Gaze-evoked nystagmus (HP:0000640)2.10040927
84Confusion (HP:0001289)2.09591869
85Delayed CNS myelination (HP:0002188)2.09554790
86Broad-based gait (HP:0002136)2.08608935
87Polyuria (HP:0000103)2.08276392
88Prolonged partial thromboplastin time (HP:0003645)2.08185449
89Postural instability (HP:0002172)2.06896850
90Syncope (HP:0001279)2.06472114
91Truncal ataxia (HP:0002078)2.05889248
92Deep venous thrombosis (HP:0002625)2.05637003
93Methylmalonic acidemia (HP:0002912)2.05254968
94Spastic gait (HP:0002064)2.04917299
95Abnormality of the gallbladder (HP:0005264)2.04799989
96Impaired vibration sensation in the lower limbs (HP:0002166)2.04560875
97Prolonged QT interval (HP:0001657)2.04296639
98Abnormality of serine family amino acid metabolism (HP:0010894)2.04098682
99Abnormality of glycine metabolism (HP:0010895)2.04098682
100Hyperbilirubinemia (HP:0002904)2.03979928
101Hypsarrhythmia (HP:0002521)2.03175324
102Bundle branch block (HP:0011710)2.01224377
103Progressive microcephaly (HP:0000253)2.01070180
104Cerebral hemorrhage (HP:0001342)2.01028941
105Abnormal urine output (HP:0012590)2.00927065
106Psychosis (HP:0000709)2.00502225
107Cystic liver disease (HP:0006706)1.99834931
108Lactic acidosis (HP:0003128)1.99414465
109Generalized myoclonic seizures (HP:0002123)1.98596554
110Sleep apnea (HP:0010535)1.98468755
111Drooling (HP:0002307)1.97934089
112Retinal atrophy (HP:0001105)1.97052585
113Heart block (HP:0012722)1.96796729
114Inability to walk (HP:0002540)1.96752209
115X-linked dominant inheritance (HP:0001423)1.96585094
116Absent speech (HP:0001344)1.96452523
117Decreased central vision (HP:0007663)1.96317419
118Abnormality of the renal medulla (HP:0100957)1.96035532
119Abnormal eating behavior (HP:0100738)1.95163337
120Clumsiness (HP:0002312)1.93330373
121Intention tremor (HP:0002080)1.92911367
122Ankle clonus (HP:0011448)1.92781154
123Xanthomatosis (HP:0000991)1.92248955
124Molar tooth sign on MRI (HP:0002419)1.91642847
125Abnormality of midbrain morphology (HP:0002418)1.91642847
126Metabolic alkalosis (HP:0200114)1.90604808
127Lethargy (HP:0001254)1.90305955
128Morphological abnormality of the pyramidal tract (HP:0002062)1.90231540
129Spastic tetraplegia (HP:0002510)1.89967827
130Respiratory failure (HP:0002878)1.89407638
131Focal dystonia (HP:0004373)1.89127980
132Metabolic acidosis (HP:0001942)1.87778799
133Reticulocytosis (HP:0001923)1.87689203
134Increased circulating renin level (HP:0000848)1.87226329
135True hermaphroditism (HP:0010459)1.86900944
136Lissencephaly (HP:0001339)1.86800277
137Ventricular fibrillation (HP:0001663)1.84660260
138Blue irides (HP:0000635)1.84460565
139Torticollis (HP:0000473)1.83549563
140Craniofacial dystonia (HP:0012179)1.82127005
141Pachygyria (HP:0001302)1.81858689
142Hemiplegia (HP:0002301)1.81607749
143Gait imbalance (HP:0002141)1.81157829
144Central scotoma (HP:0000603)1.78952915
145Termporal pattern (HP:0011008)1.78760811
146Insidious onset (HP:0003587)1.78760811
147Gout (HP:0001997)1.78753974
148Resting tremor (HP:0002322)1.78379057
149Hypomagnesemia (HP:0002917)1.77279084
150Renal Fanconi syndrome (HP:0001994)1.76383137
151Increased intramyocellular lipid droplets (HP:0012240)1.75749512
152Abolished electroretinogram (ERG) (HP:0000550)1.75550442
153Ulnar claw (HP:0001178)1.75419117
154Hypobetalipoproteinemia (HP:0003563)1.75219826
155Hyperglycinemia (HP:0002154)1.75184153
156Tubular atrophy (HP:0000092)1.75092342
157Abnormal EKG (HP:0003115)1.75049287
158CNS hypomyelination (HP:0003429)1.74466970
159Retinal dysplasia (HP:0007973)1.73408790
160Cerebral palsy (HP:0100021)1.73192763
161Megalencephaly (HP:0001355)1.72665549

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.84653381
2NTRK33.30309669
3CASK3.24066226
4MAP3K43.03289778
5MAP2K72.66907552
6FRK2.49719189
7OXSR12.39728428
8MAP2K42.37972129
9MAP3K92.13047025
10DAPK22.07187064
11STK392.00853144
12MAP3K122.00399178
13CDK191.85043418
14GRK51.72210758
15MAP4K21.68678429
16MINK11.60033421
17SGK4941.58252282
18SGK2231.58252282
19PLK21.57407609
20WNK41.47028837
21PKN11.44579958
22GRK71.42873236
23CAMK2B1.42175906
24NME11.41998018
25NTRK11.39578390
26PHKG11.39464062
27PHKG21.39464062
28PAK61.39092940
29PNCK1.38408161
30CAMK2A1.34472665
31NTRK21.29353149
32CDK51.29254480
33BCKDK1.29219873
34KSR21.28504197
35INSRR1.27162979
36PINK11.25054351
37ARAF1.24192799
38GRK11.23869065
39MAPKAPK51.23238061
40RIPK41.22097324
41PRPF4B1.21132508
42MARK11.20537475
43CAMK2D1.18652599
44PRKD31.18080240
45UHMK11.16941408
46TNIK1.16049270
47PRKCG1.11903778
48CAMKK21.10922405
49MAP3K131.10857753
50MUSK1.10444989
51TYRO31.08853250
52FES1.05877284
53TAOK31.05086013
54CAMK2G1.02810869
55MAPKAPK31.02601673
56PTK2B1.01792350
57FGR1.01093265
58DAPK11.00168656
59DYRK20.94725109
60WNK10.91796204
61MAPK130.91739444
62BMPR1B0.91067027
63CAMKK10.90690985
64MAP2K60.90455384
65BMPR20.87501524
66PRKCE0.84038524
67PRKCH0.83843218
68CAMK40.81801182
69MAPK120.78477595
70FGFR20.78199286
71PIK3CA0.78036217
72ADRBK20.77162642
73MAP3K70.76688597
74SGK20.76587624
75PRKAA10.75221114
76ERBB40.73494041
77ROCK20.73077917
78AKT30.71291946
79CDK180.71039156
80PAK30.70753543
81CDK150.70439627
82PDPK10.70310081
83DYRK1A0.70182595
84SGK10.69878425
85CAMK10.69728252
86BCR0.69539270
87CDK140.68524328
88PDK30.66164045
89PDK40.66164045
90MAP3K20.66062226
91MYLK0.63530495
92LMTK20.63483885
93CAMK1D0.62244957
94ADRBK10.61980122
95KSR10.61814466
96MAP3K110.61348546
97MAP3K10.60707986
98CSNK1G20.60707929
99ERBB20.60259124
100STK110.60241140
101RPS6KA30.60161480
102PRKACA0.60141291
103DAPK30.58895799
104WNK30.58747133
105SGK30.57828788
106CDK11A0.57291283
107PDK10.56657837
108TLK10.56463277
109PRKAA20.56385041
110GRK60.55658511
111STK380.55579865
112RET0.54784180
113SIK20.54684446
114PRKCA0.52551743
115DYRK1B0.51231237
116MARK20.50782618
117OBSCN0.50486174
118MAP3K60.50429683
119CDC42BPA0.50092696
120CSNK1A10.49793153
121PRKCI0.49009563
122TNK20.48710495
123PRKG10.48586180
124PRKCZ0.47975903
125PRKACG0.47404198
126MAP2K10.47070649
127NUAK10.45051185
128LIMK10.43548224
129ZAK0.42750687
130EEF2K0.41421607
131TRPM70.41353503
132MAP2K20.40150454
133BRSK10.37641889

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.60213111
2Nicotine addiction_Homo sapiens_hsa050332.47008511
3Synaptic vesicle cycle_Homo sapiens_hsa047212.44338974
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43460512
5Collecting duct acid secretion_Homo sapiens_hsa049662.32215048
6Nitrogen metabolism_Homo sapiens_hsa009102.11849640
7GABAergic synapse_Homo sapiens_hsa047272.03044896
8Parkinsons disease_Homo sapiens_hsa050121.97891828
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89102931
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88672049
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88027194
12Butanoate metabolism_Homo sapiens_hsa006501.85005062
13Linoleic acid metabolism_Homo sapiens_hsa005911.77481452
14Alzheimers disease_Homo sapiens_hsa050101.75387822
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.72907280
16Fatty acid elongation_Homo sapiens_hsa000621.67987196
17Morphine addiction_Homo sapiens_hsa050321.63388090
18Circadian entrainment_Homo sapiens_hsa047131.56983516
19Glutamatergic synapse_Homo sapiens_hsa047241.56208373
20Arginine biosynthesis_Homo sapiens_hsa002201.55122781
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55059293
22Olfactory transduction_Homo sapiens_hsa047401.52079663
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50421268
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49754091
25Caffeine metabolism_Homo sapiens_hsa002321.49584828
26Propanoate metabolism_Homo sapiens_hsa006401.49065627
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48519254
28Pyruvate metabolism_Homo sapiens_hsa006201.47544447
29Amphetamine addiction_Homo sapiens_hsa050311.45043987
30Cardiac muscle contraction_Homo sapiens_hsa042601.44779932
31Vitamin B6 metabolism_Homo sapiens_hsa007501.43779800
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43119477
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39471724
34Insulin secretion_Homo sapiens_hsa049111.39369226
35Taste transduction_Homo sapiens_hsa047421.39044991
36Sulfur metabolism_Homo sapiens_hsa009201.36920579
37Long-term potentiation_Homo sapiens_hsa047201.35641383
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35272202
39Salivary secretion_Homo sapiens_hsa049701.31265995
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23494541
41Dopaminergic synapse_Homo sapiens_hsa047281.20679607
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.18090693
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17698449
44Huntingtons disease_Homo sapiens_hsa050161.12437029
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11388856
46Retinol metabolism_Homo sapiens_hsa008301.11314123
47Serotonergic synapse_Homo sapiens_hsa047261.11239246
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10863656
49Histidine metabolism_Homo sapiens_hsa003401.09727975
50Vibrio cholerae infection_Homo sapiens_hsa051101.09596657
51Tryptophan metabolism_Homo sapiens_hsa003801.07300555
52Renin secretion_Homo sapiens_hsa049241.06423089
53Cocaine addiction_Homo sapiens_hsa050301.04784123
54Fatty acid degradation_Homo sapiens_hsa000711.03855313
55Gastric acid secretion_Homo sapiens_hsa049711.03687333
56Bile secretion_Homo sapiens_hsa049761.03138949
57Fatty acid metabolism_Homo sapiens_hsa012121.01245463
58Peroxisome_Homo sapiens_hsa041460.99104111
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97131929
60Fat digestion and absorption_Homo sapiens_hsa049750.96596668
61Phototransduction_Homo sapiens_hsa047440.96201388
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96092023
63Calcium signaling pathway_Homo sapiens_hsa040200.94550492
64Phenylalanine metabolism_Homo sapiens_hsa003600.93937783
65Cholinergic synapse_Homo sapiens_hsa047250.93778147
66Fatty acid biosynthesis_Homo sapiens_hsa000610.93000407
67Long-term depression_Homo sapiens_hsa047300.91679575
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88331912
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82664782
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82498581
71Tyrosine metabolism_Homo sapiens_hsa003500.82281263
72beta-Alanine metabolism_Homo sapiens_hsa004100.82164909
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81384000
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80020739
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78146269
76Sulfur relay system_Homo sapiens_hsa041220.76839549
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76608769
78Mineral absorption_Homo sapiens_hsa049780.75546405
79Arachidonic acid metabolism_Homo sapiens_hsa005900.74766680
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73837693
81Ovarian steroidogenesis_Homo sapiens_hsa049130.73585125
82Oxytocin signaling pathway_Homo sapiens_hsa049210.71195142
83Carbon metabolism_Homo sapiens_hsa012000.71159308
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69305952
85Thyroid hormone synthesis_Homo sapiens_hsa049180.68818731
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68202807
87PPAR signaling pathway_Homo sapiens_hsa033200.66441376
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.62648325
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62157410
90Pancreatic secretion_Homo sapiens_hsa049720.59613191
91Complement and coagulation cascades_Homo sapiens_hsa046100.59315066
92Arginine and proline metabolism_Homo sapiens_hsa003300.57333986
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.56822684
94Chemical carcinogenesis_Homo sapiens_hsa052040.56613337
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56052075
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55421137
97cAMP signaling pathway_Homo sapiens_hsa040240.55352329
98Type II diabetes mellitus_Homo sapiens_hsa049300.54861828
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54846242
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54663995
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.53623808
102Gap junction_Homo sapiens_hsa045400.53246467
103Steroid biosynthesis_Homo sapiens_hsa001000.53000129
104ABC transporters_Homo sapiens_hsa020100.51751705
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50153600
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50149235
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49489071
108Circadian rhythm_Homo sapiens_hsa047100.49165370
109Biosynthesis of amino acids_Homo sapiens_hsa012300.48904956
110Glucagon signaling pathway_Homo sapiens_hsa049220.48599108
111GnRH signaling pathway_Homo sapiens_hsa049120.47291231
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46563385
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.46252113
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46169745
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.43476418
116Metabolic pathways_Homo sapiens_hsa011000.39813712
117Ether lipid metabolism_Homo sapiens_hsa005650.39011720
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38483495
119Glycerolipid metabolism_Homo sapiens_hsa005610.38309900

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