FN3KRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)6.92248072
2presynaptic membrane assembly (GO:0097105)5.95582331
3axon ensheathment in central nervous system (GO:0032291)5.84226180
4central nervous system myelination (GO:0022010)5.84226180
5protein maturation by protein folding (GO:0022417)5.42815542
6presynaptic membrane organization (GO:0097090)5.21129837
7positive regulation of protein kinase C signaling (GO:0090037)5.20832601
8neuronal action potential propagation (GO:0019227)5.20292820
9postsynaptic membrane organization (GO:0001941)5.16330058
10negative regulation of execution phase of apoptosis (GO:1900118)4.98785642
11protoporphyrinogen IX metabolic process (GO:0046501)4.93521496
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.90315890
13Golgi transport vesicle coating (GO:0048200)4.79610353
14COPI coating of Golgi vesicle (GO:0048205)4.79610353
15DNA strand elongation involved in DNA replication (GO:0006271)4.79110574
16DNA strand elongation (GO:0022616)4.74967905
17DNA unwinding involved in DNA replication (GO:0006268)4.67932493
18telomere maintenance via semi-conservative replication (GO:0032201)4.66550491
19cranial nerve morphogenesis (GO:0021602)4.64653461
20protoporphyrinogen IX biosynthetic process (GO:0006782)4.55184748
21protein retention in ER lumen (GO:0006621)4.47377329
22proline biosynthetic process (GO:0006561)4.43614587
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.39845807
24metanephric tubule development (GO:0072170)4.32658427
25metanephric nephron tubule development (GO:0072234)4.32658427
26facial nerve structural organization (GO:0021612)4.27181658
27eyelid development in camera-type eye (GO:0061029)4.14334633
28cranial nerve structural organization (GO:0021604)4.05410167
29retina layer formation (GO:0010842)3.96487678
30neuron cell-cell adhesion (GO:0007158)3.83999279
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82588130
32mitotic chromosome condensation (GO:0007076)3.78677900
33negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.77486318
34melanin metabolic process (GO:0006582)3.77273958
35metanephric nephron epithelium development (GO:0072243)3.77060501
36righting reflex (GO:0060013)3.76945689
37L-serine metabolic process (GO:0006563)3.65887778
38folic acid metabolic process (GO:0046655)3.63898912
392-deoxyribonucleotide biosynthetic process (GO:0009265)3.63093847
40deoxyribose phosphate biosynthetic process (GO:0046385)3.63093847
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.62404099
42organ growth (GO:0035265)3.60431083
43establishment of integrated proviral latency (GO:0075713)3.59800831
44metanephric epithelium development (GO:0072207)3.57259144
45nucleobase-containing small molecule interconversion (GO:0015949)3.52744404
46telomere maintenance via recombination (GO:0000722)3.51234528
47regulation of mitotic spindle organization (GO:0060236)3.50238817
48regulation of protein kinase A signaling (GO:0010738)3.49534830
49deoxyribonucleotide biosynthetic process (GO:0009263)3.48644798
50omega-hydroxylase P450 pathway (GO:0097267)3.47002211
51sympathetic nervous system development (GO:0048485)3.46432950
52melanin biosynthetic process (GO:0042438)3.45803263
53negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.45796710
54DNA replication initiation (GO:0006270)3.41728408
55heme biosynthetic process (GO:0006783)3.41542250
56GDP-mannose metabolic process (GO:0019673)3.39422124
57limb bud formation (GO:0060174)3.37943152
58response to methylmercury (GO:0051597)3.36652943
59protein localization to synapse (GO:0035418)3.34191200
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.32863512
61regulation of mammary gland epithelial cell proliferation (GO:0033599)3.32301339
62regulation of mitochondrial translation (GO:0070129)3.30179297
63proline metabolic process (GO:0006560)3.29951294
64mitotic recombination (GO:0006312)3.29707478
65peptidyl-arginine omega-N-methylation (GO:0035247)3.26715361
66ionotropic glutamate receptor signaling pathway (GO:0035235)3.25063330
67mitotic sister chromatid segregation (GO:0000070)3.24468396
68positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.23022895
69lymphoid progenitor cell differentiation (GO:0002320)3.19785857
70secondary metabolite biosynthetic process (GO:0044550)3.19281970
71pattern specification involved in kidney development (GO:0061004)3.19251804
72spliceosomal tri-snRNP complex assembly (GO:0000244)3.18273853
73cerebral cortex radially oriented cell migration (GO:0021799)3.16306380
74GMP metabolic process (GO:0046037)3.14826798
754-hydroxyproline metabolic process (GO:0019471)3.14371658
76lens development in camera-type eye (GO:0002088)3.13936335
77nephron epithelium development (GO:0072009)3.11907944
78mesonephros development (GO:0001823)3.11707069
79positive regulation of synapse assembly (GO:0051965)3.10768759
80positive regulation of dendritic spine development (GO:0060999)3.09894733
81cornea development in camera-type eye (GO:0061303)3.09255536
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08107310
83regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.07843300
84nucleotide-excision repair, DNA gap filling (GO:0006297)3.07734085
85regulation of translational fidelity (GO:0006450)3.07344810
86ribosomal small subunit biogenesis (GO:0042274)3.07342191
87L-amino acid import (GO:0043092)3.06415517
88nuclear envelope reassembly (GO:0031468)3.05859610
89mitotic nuclear envelope reassembly (GO:0007084)3.05859610
90tetrapyrrole biosynthetic process (GO:0033014)3.05656869
91regulation of timing of cell differentiation (GO:0048505)3.03623161
92photoreceptor cell maintenance (GO:0045494)3.02775702
93forebrain neuron development (GO:0021884)3.00436823
94regulation of spindle organization (GO:0090224)2.99851110
95positive regulation of membrane potential (GO:0045838)2.99590978
96regulation of exit from mitosis (GO:0007096)2.99410656
97porphyrin-containing compound biosynthetic process (GO:0006779)2.98964123
98formation of translation preinitiation complex (GO:0001731)2.98121373
99oligodendrocyte differentiation (GO:0048709)2.97998502
100negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97186823
101positive regulation of meiosis (GO:0045836)2.96434525
102regulation of mesenchymal cell apoptotic process (GO:2001053)2.94978331
103establishment of viral latency (GO:0019043)2.94224446
104centriole replication (GO:0007099)2.94058552
105glycolytic process (GO:0006096)2.92380350
106glutamate receptor signaling pathway (GO:0007215)2.91748949
107regulation of pigment cell differentiation (GO:0050932)2.90970167
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90449428
109telomere maintenance via telomere lengthening (GO:0010833)2.90400033
110pentose-phosphate shunt (GO:0006098)2.89698403
111gluconeogenesis (GO:0006094)2.89321681
112positive regulation of meiotic cell cycle (GO:0051446)2.87445681
113cell differentiation involved in metanephros development (GO:0072202)2.87426015
114nephron tubule development (GO:0072080)2.87074134
115glucose catabolic process (GO:0006007)2.85236630
116negative regulation of keratinocyte proliferation (GO:0010839)2.84661839
117negative regulation of DNA-templated transcription, elongation (GO:0032785)2.84356964
118anatomical structure arrangement (GO:0048532)2.83459457
119mesenchymal cell differentiation involved in renal system development (GO:2001012)2.83383539
120mesenchymal cell differentiation involved in kidney development (GO:0072161)2.83383539
121positive regulation of dendritic spine morphogenesis (GO:0061003)2.83016454
122negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82340478
123positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.82099665
124regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.82099665
125thyroid gland development (GO:0030878)2.81636077
126positive regulation of cellular amine metabolic process (GO:0033240)2.81519154
127mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.81109233
128histone arginine methylation (GO:0034969)2.80968076
129fatty acid elongation (GO:0030497)2.80590534
130monosaccharide biosynthetic process (GO:0046364)2.79762522
131galactose catabolic process (GO:0019388)2.79149132
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78400955
133regulation of development, heterochronic (GO:0040034)2.77754716
134UV protection (GO:0009650)2.77534675
135hexose biosynthetic process (GO:0019319)2.76953396
136centriole assembly (GO:0098534)2.76545814
137virion assembly (GO:0019068)2.76506394
138peptidyl-proline hydroxylation (GO:0019511)2.75590941
139negative regulation of neurotransmitter transport (GO:0051589)2.75448724
140pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75312115
141ncRNA 3-end processing (GO:0043628)2.75303533
142serine family amino acid biosynthetic process (GO:0009070)2.75140291
143pyrimidine-containing compound salvage (GO:0008655)2.74235000
144pyrimidine nucleoside salvage (GO:0043097)2.74235000
145regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.73986045
146glycogen catabolic process (GO:0005980)2.73933301
147base-excision repair (GO:0006284)2.72961909
148de novo posttranslational protein folding (GO:0051084)2.71806734
149de novo protein folding (GO:0006458)2.70889257
150sister chromatid segregation (GO:0000819)2.70330658
151regulation of glutamate receptor signaling pathway (GO:1900449)2.70091644
152startle response (GO:0001964)2.69418488
153NADPH regeneration (GO:0006740)2.68534072
154regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.68405548
155negative regulation of Ras GTPase activity (GO:0034261)2.67600947
156mitotic metaphase plate congression (GO:0007080)2.67350022
157mechanosensory behavior (GO:0007638)2.67225730
158peptidyl-arginine N-methylation (GO:0035246)2.67077293
159peptidyl-arginine methylation (GO:0018216)2.67077293
160negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.66735095
161negative regulation of ligase activity (GO:0051352)2.66735095
162cranial nerve development (GO:0021545)2.66721067
163adult walking behavior (GO:0007628)2.65301035
164eye photoreceptor cell differentiation (GO:0001754)2.65203022
165photoreceptor cell differentiation (GO:0046530)2.65203022
166nucleoside diphosphate biosynthetic process (GO:0009133)2.64805841
167heme metabolic process (GO:0042168)2.64325423
168synaptic transmission, glutamatergic (GO:0035249)2.64313560
169regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63906737
170long-chain fatty acid biosynthetic process (GO:0042759)2.62631933
171neurotransmitter-gated ion channel clustering (GO:0072578)2.62290008
172DNA topological change (GO:0006265)2.61986696
173response to folic acid (GO:0051593)2.61857472
174positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.61386836
175viral genome replication (GO:0019079)2.60875999
176negative regulation of cell size (GO:0045792)2.60336302
177positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60052171
178negative regulation of mRNA processing (GO:0050686)2.58484343
179import into cell (GO:0098657)2.58388689
180vocalization behavior (GO:0071625)2.57757260
181DNA deamination (GO:0045006)2.57205799
182regulation of respiratory system process (GO:0044065)2.56866224
183regulation of protein kinase C signaling (GO:0090036)2.56835244
184negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.56759585
185long-term memory (GO:0007616)2.56117400
186pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.55227851
187ribosome assembly (GO:0042255)2.55040642
188transcription-coupled nucleotide-excision repair (GO:0006283)2.52572994
189protein-DNA complex disassembly (GO:0032986)2.50996193
190nucleosome disassembly (GO:0006337)2.50996193
191lipopolysaccharide biosynthetic process (GO:0009103)2.48493144
192pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.47746097
193maturation of SSU-rRNA (GO:0030490)2.46515704
194barbed-end actin filament capping (GO:0051016)2.46219974
195positive regulation of nuclease activity (GO:0032075)2.46145307
196chaperone-mediated protein transport (GO:0072321)2.45256617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45703028
2E2F7_22180533_ChIP-Seq_HELA_Human5.54472523
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.93155166
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.63159861
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.60211859
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.55785332
7GBX2_23144817_ChIP-Seq_PC3_Human3.46466653
8EZH2_27304074_Chip-Seq_ESCs_Mouse3.19564697
9EED_16625203_ChIP-ChIP_MESCs_Mouse3.15449072
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92029643
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91014169
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.89165824
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.87860039
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80063603
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76210926
16RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.75039660
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.73408298
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72976926
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72976926
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.63941728
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.61965909
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59179840
23TAF15_26573619_Chip-Seq_HEK293_Human2.56496325
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.54082190
25IGF1R_20145208_ChIP-Seq_DFB_Human2.40231329
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37608336
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37059262
28ZNF263_19887448_ChIP-Seq_K562_Human2.33867938
29AR_21572438_ChIP-Seq_LNCaP_Human2.31279529
30EZH2_27294783_Chip-Seq_ESCs_Mouse2.24840300
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23762162
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23232235
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21672094
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18128669
35FOXM1_23109430_ChIP-Seq_U2OS_Human2.15006553
36SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14576665
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13669383
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.11863052
39MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10795137
40RNF2_27304074_Chip-Seq_ESCs_Mouse2.07797726
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06016085
42POU5F1_16153702_ChIP-ChIP_HESCs_Human2.04517880
43XRN2_22483619_ChIP-Seq_HELA_Human2.03841257
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.99066153
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98196317
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96254875
47RNF2_27304074_Chip-Seq_NSC_Mouse1.92074685
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89403811
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87070591
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86136299
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85056385
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84179454
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84087586
54LXR_22292898_ChIP-Seq_THP-1_Human1.83339609
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82276917
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77683015
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76352868
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73342352
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.73011300
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72960760
61VDR_22108803_ChIP-Seq_LS180_Human1.72912364
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67948341
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65850617
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.65784562
65VDR_21846776_ChIP-Seq_THP-1_Human1.63155016
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61735426
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61069745
68DCP1A_22483619_ChIP-Seq_HELA_Human1.60744390
69MYC_22102868_ChIP-Seq_BL_Human1.60723597
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59091938
71GABP_19822575_ChIP-Seq_HepG2_Human1.58352419
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.58029639
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57728463
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.57601958
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57185228
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55171921
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54139191
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52569904
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.51290757
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50523518
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47271584
82RACK7_27058665_Chip-Seq_MCF-7_Human1.47247863
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45484193
84IRF1_19129219_ChIP-ChIP_H3396_Human1.44321496
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42648195
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42590769
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40646677
88P300_19829295_ChIP-Seq_ESCs_Human1.39981602
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38931492
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38830262
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38827565
92* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38488537
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37201056
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37001473
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36372815
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35960402
97AR_21909140_ChIP-Seq_LNCAP_Human1.34408295
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.31404356
99KDM5A_27292631_Chip-Seq_BREAST_Human1.31217529
100REST_21632747_ChIP-Seq_MESCs_Mouse1.31201995
101P68_20966046_ChIP-Seq_HELA_Human1.29904465
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29240741
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.28604233
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.27721151
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27173648
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26540853
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26438435
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26399340
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.25063820
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.24634019
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23777004
112FUS_26573619_Chip-Seq_HEK293_Human1.23695637
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.22578879
114TTF2_22483619_ChIP-Seq_HELA_Human1.22003057
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21250709
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21222147
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21154671
118ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21097970
119IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19949356
120CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19147754
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19098060
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18840128
123E2F1_21310950_ChIP-Seq_MCF-7_Human1.18347665
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.17751287
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16688545
126ER_23166858_ChIP-Seq_MCF-7_Human1.16192457
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16130736
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16031465
129CIITA_25753668_ChIP-Seq_RAJI_Human1.15947968
130P53_22387025_ChIP-Seq_ESCs_Mouse1.15630424
131P300_18555785_Chip-Seq_ESCs_Mouse1.15527466
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14243626
133PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13640827
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13364219
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13214933
136SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12615539
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12548081
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12307692
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12055646
140EZH2_27294783_Chip-Seq_NPCs_Mouse1.11277244
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11180525
142SOX2_16153702_ChIP-ChIP_HESCs_Human1.10817870
143OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10804565
144CLOCK_20551151_ChIP-Seq_293T_Human1.10275030
145ELF1_20517297_ChIP-Seq_JURKAT_Human1.10072577
146REST_18959480_ChIP-ChIP_MESCs_Mouse1.09350835
147SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08651556
148UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08057107
149NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07918709
150TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07650565
151KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07206184
152SMAD4_21799915_ChIP-Seq_A2780_Human1.06609715
153RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06470194
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06286061
155SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05556143
156SRF_21415370_ChIP-Seq_HL-1_Mouse1.05364691
157E2F1_18555785_Chip-Seq_ESCs_Mouse1.05087977
158* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04084736
159PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03998751
160FOXP1_21924763_ChIP-Seq_HESCs_Human1.03466989
161BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03314646
162GABP_17652178_ChIP-ChIP_JURKAT_Human1.03199974
163CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03166004
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02674660
165CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01063057
166KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01040620
167STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00831264
168EST1_17652178_ChIP-ChIP_JURKAT_Human1.00750240
169EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99760060
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.99241689
171MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99132421
172SA1_27219007_Chip-Seq_ERYTHROID_Human0.98932431
173NMYC_18555785_Chip-Seq_ESCs_Mouse0.98718788
174E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98323388
175EGR1_19374776_ChIP-ChIP_THP-1_Human0.97593532
176EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96656343
177STAT3_18555785_Chip-Seq_ESCs_Mouse0.95895894
178TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94292388
179RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94225883
180CMYC_18555785_Chip-Seq_ESCs_Mouse0.93154902
181RUNX2_22187159_ChIP-Seq_PCA_Human0.92726505
182SOX2_18555785_Chip-Seq_ESCs_Mouse0.92444155
183MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91555509
184SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90145031
185* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89392314
186ZFX_18555785_Chip-Seq_ESCs_Mouse0.87988495
187NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87932869
188KLF4_18555785_Chip-Seq_ESCs_Mouse0.86766655
189TAL1_26923725_Chip-Seq_HPCs_Mouse0.85606430
190ZNF274_21170338_ChIP-Seq_K562_Hela0.83467442
191CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83415089
192UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83366577
193OCT4_18555785_Chip-Seq_ESCs_Mouse0.82389727
194LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81973352
195CTCF_18555785_Chip-Seq_ESCs_Mouse0.81906751
196ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81396658
197* STAT3_23295773_ChIP-Seq_U87_Human0.81292254
198MYC_18940864_ChIP-ChIP_HL60_Human0.81262835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.26990055
2MP0005409_darkened_coat_color4.69710634
3MP0001188_hyperpigmentation4.46376694
4MP0002877_abnormal_melanocyte_morpholog4.00883357
5MP0004381_abnormal_hair_follicle3.77045091
6MP0003111_abnormal_nucleus_morphology3.69210573
7MP0003880_abnormal_central_pattern3.50372661
8MP0006292_abnormal_olfactory_placode3.40461313
9MP0010094_abnormal_chromosome_stability3.35097572
10MP0003705_abnormal_hypodermis_morpholog3.29266397
11MP0003693_abnormal_embryo_hatching3.02894084
12MP0005257_abnormal_intraocular_pressure2.96162899
13MP0009379_abnormal_foot_pigmentation2.92408932
14MP0003123_paternal_imprinting2.73001537
15MP0008932_abnormal_embryonic_tissue2.70181816
16MP0003077_abnormal_cell_cycle2.68250937
17MP0000566_synostosis2.67714112
18MP0000015_abnormal_ear_pigmentation2.47381975
19MP0005174_abnormal_tail_pigmentation2.42300028
20MP0003806_abnormal_nucleotide_metabolis2.37040919
21MP0002102_abnormal_ear_morphology2.36984994
22MP0002822_catalepsy2.36954723
23MP0004147_increased_porphyrin_level2.31188709
24MP0002638_abnormal_pupillary_reflex2.29338972
25MP0001968_abnormal_touch/_nociception2.23359475
26MP0005058_abnormal_lysosome_morphology2.21126806
27MP0004957_abnormal_blastocyst_morpholog2.16757690
28MP0004142_abnormal_muscle_tone2.07000213
29MP0001486_abnormal_startle_reflex2.04678448
30MP0009046_muscle_twitch1.94989083
31MP0003011_delayed_dark_adaptation1.91715914
32MP0003938_abnormal_ear_development1.83824547
33MP0001730_embryonic_growth_arrest1.83435877
34MP0004859_abnormal_synaptic_plasticity1.80762057
35MP0009278_abnormal_bone_marrow1.80611541
36MP0005408_hypopigmentation1.79883465
37MP0002249_abnormal_larynx_morphology1.75688638
38MP0001849_ear_inflammation1.74443859
39MP0003656_abnormal_erythrocyte_physiolo1.72967244
40MP0000049_abnormal_middle_ear1.72764669
41MP0004742_abnormal_vestibular_system1.71456676
42MP0002272_abnormal_nervous_system1.69504394
43MP0005423_abnormal_somatic_nervous1.69211585
44MP0003329_amyloid_beta_deposits1.67163335
45MP0002067_abnormal_sensory_capabilities1.66179040
46MP0008058_abnormal_DNA_repair1.65596087
47MP0003635_abnormal_synaptic_transmissio1.64893138
48MP0005501_abnormal_skin_physiology1.62191675
49MP0000350_abnormal_cell_proliferation1.62047594
50MP0000778_abnormal_nervous_system1.60629990
51MP0003191_abnormal_cellular_cholesterol1.59871375
52MP0003186_abnormal_redox_activity1.59243555
53MP0009745_abnormal_behavioral_response1.56588717
54MP0002064_seizures1.53550975
55MP0003315_abnormal_perineum_morphology1.51238700
56MP0002734_abnormal_mechanical_nocicepti1.51204400
57MP0004858_abnormal_nervous_system1.51144355
58MP0003566_abnormal_cell_adhesion1.50930111
59MP0004233_abnormal_muscle_weight1.49813983
60MP0004270_analgesia1.48677069
61MP0008007_abnormal_cellular_replicative1.47903369
62MP0010030_abnormal_orbit_morphology1.45419861
63MP0005670_abnormal_white_adipose1.44869060
64MP0002095_abnormal_skin_pigmentation1.43924145
65MP0002177_abnormal_outer_ear1.42673700
66MP0000631_abnormal_neuroendocrine_gland1.39415032
67MP0006036_abnormal_mitochondrial_physio1.39095964
68MP0003786_premature_aging1.36691156
69MP0002080_prenatal_lethality1.35783407
70MP0008260_abnormal_autophagy1.35475919
71MP0001905_abnormal_dopamine_level1.34892048
72MP0009840_abnormal_foam_cell1.34467535
73MP0003122_maternal_imprinting1.34086657
74MP0006276_abnormal_autonomic_nervous1.31725450
75MP0001346_abnormal_lacrimal_gland1.28833956
76MP0004185_abnormal_adipocyte_glucose1.28700697
77MP0008789_abnormal_olfactory_epithelium1.28572685
78MP0000026_abnormal_inner_ear1.26902653
79MP0002751_abnormal_autonomic_nervous1.25314010
80MP0005551_abnormal_eye_electrophysiolog1.23989006
81MP0002752_abnormal_somatic_nervous1.18764301
82MP0000358_abnormal_cell_content/1.17257832
83MP0005171_absent_coat_pigmentation1.16813372
84MP0005645_abnormal_hypothalamus_physiol1.16119122
85MP0002557_abnormal_social/conspecific_i1.15162660
86MP0005499_abnormal_olfactory_system1.14937214
87MP0005394_taste/olfaction_phenotype1.14937214
88MP0005623_abnormal_meninges_morphology1.14213283
89MP0002572_abnormal_emotion/affect_behav1.13609154
90MP0005621_abnormal_cell_physiology1.12589049
91MP0001970_abnormal_pain_threshold1.12296322
92MP0009672_abnormal_birth_weight1.12174615
93MP0002735_abnormal_chemical_nociception1.11311174
94MP0005646_abnormal_pituitary_gland1.11048220
95MP0005384_cellular_phenotype1.10145154
96MP0008438_abnormal_cutaneous_collagen1.09382671
97MP0002736_abnormal_nociception_after1.09189492
98MP0002876_abnormal_thyroid_physiology1.08589626
99MP0001697_abnormal_embryo_size1.04624741
100MP0008569_lethality_at_weaning1.03163352
101MP0000920_abnormal_myelination1.03148514
102MP0000313_abnormal_cell_death1.02906225
103MP0002882_abnormal_neuron_morphology1.02899879
104MP0008995_early_reproductive_senescence0.98795272
105MP0001986_abnormal_taste_sensitivity0.98541453
106MP0002063_abnormal_learning/memory/cond0.98472240
107MP0003172_abnormal_lysosome_physiology0.97867216
108MP0001529_abnormal_vocalization0.97252755
109MP0001672_abnormal_embryogenesis/_devel0.96726443
110MP0005380_embryogenesis_phenotype0.96726443
111MP0001963_abnormal_hearing_physiology0.96383600
112MP0002184_abnormal_innervation0.96011518
113MP0002277_abnormal_respiratory_mucosa0.95903059
114MP0009250_abnormal_appendicular_skeleto0.95142768
115MP0005253_abnormal_eye_physiology0.95068112
116MP0004264_abnormal_extraembryonic_tissu0.94624492
117MP0005666_abnormal_adipose_tissue0.94614492
118MP0003121_genomic_imprinting0.93337786
119MP0002060_abnormal_skin_morphology0.92275152
120MP0001286_abnormal_eye_development0.92198227
121MP0000467_abnormal_esophagus_morphology0.91069127
122MP0006035_abnormal_mitochondrial_morpho0.90968281
123MP0001485_abnormal_pinna_reflex0.90735483
124MP0000678_abnormal_parathyroid_gland0.90733739
125MP0004885_abnormal_endolymph0.90685769
126MP0000858_altered_metastatic_potential0.90343774
127MP0002796_impaired_skin_barrier0.90285477
128MP0002229_neurodegeneration0.86943955
129MP0003942_abnormal_urinary_system0.86784072
130MP0009333_abnormal_splenocyte_physiolog0.86528788
131MP0001881_abnormal_mammary_gland0.85334011
132MP0005379_endocrine/exocrine_gland_phen0.85256732
133MP0005075_abnormal_melanosome_morpholog0.84096127
134MP0000681_abnormal_thyroid_gland0.83723364
135MP0002970_abnormal_white_adipose0.83656295
136MP0001542_abnormal_bone_strength0.83163577
137MP0000537_abnormal_urethra_morphology0.82907584
138MP0000490_abnormal_crypts_of0.82573854
139MP0003937_abnormal_limbs/digits/tail_de0.82541073
140MP0005195_abnormal_posterior_eye0.82167398
141MP0000955_abnormal_spinal_cord0.82079729
142MP0002019_abnormal_tumor_incidence0.81702066
143MP0000534_abnormal_ureter_morphology0.81357849
144MP0002152_abnormal_brain_morphology0.80505241
145MP0000003_abnormal_adipose_tissue0.80383123
146MP0005076_abnormal_cell_differentiation0.80247127
147MP0010234_abnormal_vibrissa_follicle0.80145702
148MP0002066_abnormal_motor_capabilities/c0.79278524
149MP0005023_abnormal_wound_healing0.78539058
150MP0002085_abnormal_embryonic_tissue0.76678928
151MP0002938_white_spotting0.76635385
152MP0002733_abnormal_thermal_nociception0.76399264
153MP0003984_embryonic_growth_retardation0.76335135
154MP0001664_abnormal_digestion0.76129286
155MP0002697_abnormal_eye_size0.76032908
156MP0001340_abnormal_eyelid_morphology0.76031156
157MP0005451_abnormal_body_composition0.75532828
158MP0000762_abnormal_tongue_morphology0.75392601
159MP0003221_abnormal_cardiomyocyte_apopto0.75376238
160MP0003385_abnormal_body_wall0.75295058
161MP0005248_abnormal_Harderian_gland0.73242432
162MP0005391_vision/eye_phenotype0.72011238
163MP0003115_abnormal_respiratory_system0.71889541
164MP0001299_abnormal_eye_distance/0.70722023
165MP0006072_abnormal_retinal_apoptosis0.68116125
166MP0004145_abnormal_muscle_electrophysio0.68052229
167MP0000613_abnormal_salivary_gland0.66697145
168MP0000579_abnormal_nail_morphology0.66048778
169MP0000428_abnormal_craniofacial_morphol0.66037016
170MP0010771_integument_phenotype0.65973854
171MP0003718_maternal_effect0.65963241
172MP0002088_abnormal_embryonic_growth/wei0.65532577
173MP0005375_adipose_tissue_phenotype0.63154848
174MP0005595_abnormal_vascular_smooth0.63116241
175MP0001984_abnormal_olfaction0.62595045
176MP0001440_abnormal_grooming_behavior0.61410332
177MP0001661_extended_life_span0.61027485
178MP0001186_pigmentation_phenotype0.60554130
179MP0002086_abnormal_extraembryonic_tissu0.60044070
180MP0003453_abnormal_keratinocyte_physiol0.59434438
181MP0002210_abnormal_sex_determination0.59167303
182MP0001764_abnormal_homeostasis0.58539757

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of secondary sexual hair (HP:0009888)6.07803602
2Abnormality of the axillary hair (HP:0100134)6.07803602
3Sex reversal (HP:0012245)5.51417279
4Abnormal sex determination (HP:0012244)5.51417279
5Focal motor seizures (HP:0011153)4.38869981
6Concave nail (HP:0001598)4.31782405
7Bile duct proliferation (HP:0001408)4.17837801
8Abnormal biliary tract physiology (HP:0012439)4.17837801
9Cholecystitis (HP:0001082)3.97018902
10Abnormal gallbladder physiology (HP:0012438)3.97018902
11Vertebral compression fractures (HP:0002953)3.80994140
12Abnormality of glycolysis (HP:0004366)3.70837124
13Obstructive sleep apnea (HP:0002870)3.41908687
14Abnormality of the heme biosynthetic pathway (HP:0010472)3.38636075
15Increased serum pyruvate (HP:0003542)3.22759202
16Nuclear cataract (HP:0100018)3.19593990
17Insomnia (HP:0100785)3.15558537
18Alacrima (HP:0000522)3.09819889
19Febrile seizures (HP:0002373)3.09172805
20Thyroid-stimulating hormone excess (HP:0002925)3.04550398
21Septo-optic dysplasia (HP:0100842)2.97201967
22Achilles tendon contracture (HP:0001771)2.94883785
23Broad-based gait (HP:0002136)2.91549989
24Zonular cataract (HP:0010920)2.88862400
25Optic nerve hypoplasia (HP:0000609)2.83174213
26Poikilocytosis (HP:0004447)2.81242917
27Aplasia/hypoplasia of the uterus (HP:0008684)2.74815469
28Hyperacusis (HP:0010780)2.73158256
29Nonprogressive disorder (HP:0003680)2.70561102
30Abnormality of the Achilles tendon (HP:0005109)2.68466180
31Split foot (HP:0001839)2.65368695
32Hypoplasia of the capital femoral epiphysis (HP:0003090)2.63820623
33Sleep apnea (HP:0010535)2.63113893
34Absent speech (HP:0001344)2.60666263
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.59449309
36Absent/shortened dynein arms (HP:0200106)2.59449309
37Absent septum pellucidum (HP:0001331)2.58747267
38Abnormality of the septum pellucidum (HP:0007375)2.57822976
39Gonadal dysgenesis (HP:0000133)2.57332791
40Decreased lacrimation (HP:0000633)2.53701678
41Ragged-red muscle fibers (HP:0003200)2.52893697
42Long palpebral fissure (HP:0000637)2.51042252
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50998645
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49153213
45Optic disc pallor (HP:0000543)2.48628657
46Attenuation of retinal blood vessels (HP:0007843)2.43603662
47Upper limb amyotrophy (HP:0009129)2.40249869
48Distal upper limb amyotrophy (HP:0007149)2.40249869
49Premature rupture of membranes (HP:0001788)2.37367286
50Stridor (HP:0010307)2.33895826
51Hand muscle atrophy (HP:0009130)2.33493157
52Nephronophthisis (HP:0000090)2.32422560
53Growth hormone excess (HP:0000845)2.31935533
54Multiple enchondromatosis (HP:0005701)2.31140222
55Hyperglycinemia (HP:0002154)2.28225448
56Trismus (HP:0000211)2.26637770
57Protrusio acetabuli (HP:0003179)2.26531161
58Supranuclear gaze palsy (HP:0000605)2.24962510
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24359619
60Abnormal ciliary motility (HP:0012262)2.20946504
61Deep venous thrombosis (HP:0002625)2.18257868
62Reticulocytosis (HP:0001923)2.16884678
63Pointed chin (HP:0000307)2.15436124
64Parakeratosis (HP:0001036)2.14721546
65Cholelithiasis (HP:0001081)2.14716303
66Back pain (HP:0003418)2.10766923
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10653551
68Patchy hypopigmentation of hair (HP:0011365)2.08937371
69Cerebral hypomyelination (HP:0006808)2.08882588
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.07661807
71Absent epiphyses (HP:0010577)2.07661807
72Abnormality of reticulocytes (HP:0004312)2.07415906
73Rough bone trabeculation (HP:0100670)2.07049724
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05862744
75Increased hepatocellular lipid droplets (HP:0006565)2.05388587
76Type I transferrin isoform profile (HP:0003642)2.05374013
77Microretrognathia (HP:0000308)2.05044589
78Broad distal phalanx of finger (HP:0009836)2.02766766
79Abnormality of cells of the erythroid lineage (HP:0012130)2.02490995
80Generalized hypotonia (HP:0001290)2.02016622
81Prolonged partial thromboplastin time (HP:0003645)2.01233096
82Chromsome breakage (HP:0040012)2.01022385
83Hypertensive crisis (HP:0100735)2.00176155
84Gaze-evoked nystagmus (HP:0000640)1.99579304
85Esotropia (HP:0000565)1.99537576
86White forelock (HP:0002211)1.97898181
87Progressive muscle weakness (HP:0003323)1.97627639
88Renal Fanconi syndrome (HP:0001994)1.97395914
89Hypothermia (HP:0002045)1.97316855
90Selective tooth agenesis (HP:0001592)1.95002021
91Macrocytic anemia (HP:0001972)1.93195265
92Abnormal respiratory epithelium morphology (HP:0012253)1.92885154
93Abnormal respiratory motile cilium morphology (HP:0005938)1.92885154
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92590974
95Nasolacrimal duct obstruction (HP:0000579)1.92376226
96Diaphragmatic weakness (HP:0009113)1.90713510
97Athetosis (HP:0002305)1.90653616
98Atonic seizures (HP:0010819)1.90387748
99Male pseudohermaphroditism (HP:0000037)1.89792581
100Abnormal number of erythroid precursors (HP:0012131)1.89698227
1013-Methylglutaconic aciduria (HP:0003535)1.88914023
102Hemiparesis (HP:0001269)1.88040186
103Duplication of thumb phalanx (HP:0009942)1.87718885
104Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.87520862
105Proximal placement of thumb (HP:0009623)1.86758798
106Acanthocytosis (HP:0001927)1.86218704
107Abnormality of the renal medulla (HP:0100957)1.84198490
108Joint hemorrhage (HP:0005261)1.84168102
109Cortical dysplasia (HP:0002539)1.84016827
110Distal lower limb muscle weakness (HP:0009053)1.83831923
111Decreased muscle mass (HP:0003199)1.82636270
112Osteomalacia (HP:0002749)1.81736827
113Epileptic encephalopathy (HP:0200134)1.80758986
114Retinal dysplasia (HP:0007973)1.80625140
115Spinal cord compression (HP:0002176)1.80104989
116Overriding aorta (HP:0002623)1.79678603
117Abnormality of carpal bone ossification (HP:0006257)1.78639412
118Spinal rigidity (HP:0003306)1.78352719
119Hypoplastic pelvis (HP:0008839)1.77873147
120Abnormal respiratory motile cilium physiology (HP:0012261)1.77872430
121Hypophosphatemic rickets (HP:0004912)1.77065290
122Supernumerary spleens (HP:0009799)1.76952092
123Severe visual impairment (HP:0001141)1.76373169
124Distal lower limb amyotrophy (HP:0008944)1.75829834
125Focal seizures (HP:0007359)1.75525484
126Hydroureter (HP:0000072)1.74738717
127Abnormal gallbladder morphology (HP:0012437)1.73602169
128Deviation of the thumb (HP:0009603)1.73125771
129Decreased central vision (HP:0007663)1.73086095
130Gout (HP:0001997)1.73027059
131Seborrheic dermatitis (HP:0001051)1.72126856
132Biconcave vertebral bodies (HP:0004586)1.71890859
133Reticulocytopenia (HP:0001896)1.71742457
134Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71613591
135Paralysis (HP:0003470)1.71421828
136Testicular atrophy (HP:0000029)1.71421493
137Ulnar bowing (HP:0003031)1.70309246
138Microglossia (HP:0000171)1.70199543
139Restlessness (HP:0000711)1.70123363
140Abnormality of the phalanges of the hallux (HP:0010057)1.69953079
141Secondary amenorrhea (HP:0000869)1.68241987
142Synostosis involving the elbow (HP:0003938)1.68202703
143Humeroradial synostosis (HP:0003041)1.68202703
144Patellar dislocation (HP:0002999)1.67704868
145Myokymia (HP:0002411)1.67231166
146Increased nuchal translucency (HP:0010880)1.66958709
147Hypokinesia (HP:0002375)1.66787629
148Short tibia (HP:0005736)1.66247033
149Deep palmar crease (HP:0006191)1.66196941
150Upper limb muscle weakness (HP:0003484)1.65903359
151Amblyopia (HP:0000646)1.65564744
152Hepatocellular necrosis (HP:0001404)1.65463684
153Dry hair (HP:0011359)1.65303650
154Abnormal rod and cone electroretinograms (HP:0008323)1.64997156
155Elfin facies (HP:0004428)1.64003099
156Sensory axonal neuropathy (HP:0003390)1.63593419
157Breast hypoplasia (HP:0003187)1.63585881
158Stage 5 chronic kidney disease (HP:0003774)1.63227708
159Hypochromic microcytic anemia (HP:0004840)1.63150109
160Short nail (HP:0001799)1.62834025
161Decreased activity of mitochondrial respiratory chain (HP:0008972)1.62375814
162Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.62375814
163Spastic paraparesis (HP:0002313)1.61857000
164Aplasia/Hypoplasia of the tibia (HP:0005772)1.61778014
165Thickened helices (HP:0000391)1.61649648
166Chin dimple (HP:0010751)1.60938970
167Myopathic facies (HP:0002058)1.60785210
168Lipid accumulation in hepatocytes (HP:0006561)1.60779928
169Abnormality of the distal phalanges of the toes (HP:0010182)1.60078518
170Elbow flexion contracture (HP:0002987)1.59993227
171Postnatal microcephaly (HP:0005484)1.59830511
172Abnormality of the umbilical cord (HP:0010881)1.58906434
173Anencephaly (HP:0002323)1.58106222
174Centrally nucleated skeletal muscle fibers (HP:0003687)1.58058913
175Microvesicular hepatic steatosis (HP:0001414)1.57921215
176Abnormality of the gallbladder (HP:0005264)1.57438584
177Annular pancreas (HP:0001734)1.57366177
178Abnormality of magnesium homeostasis (HP:0004921)1.57053168
179Mitochondrial inheritance (HP:0001427)1.57012470
180Flattened epiphyses (HP:0003071)1.56620135
181Muscle stiffness (HP:0003552)1.56566360
182Hyperparathyroidism (HP:0000843)1.56380474
183Microcytic anemia (HP:0001935)1.56368969
184Agammaglobulinemia (HP:0004432)1.55959221
185Mitral regurgitation (HP:0001653)1.55893807
186Abnormality of the pulmonary veins (HP:0011718)1.54720039
187Glossoptosis (HP:0000162)1.54027148
188Delusions (HP:0000746)1.52713756
189Distal sensory impairment (HP:0002936)1.52559550
190Irregular epiphyses (HP:0010582)1.52506126
191Hemorrhage of the eye (HP:0011885)1.51928081
192Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.50870421
193Down-sloping shoulders (HP:0200021)1.49299440
194Renal duplication (HP:0000075)1.48993163
195Fasciculations (HP:0002380)1.48741486
196Pseudobulbar signs (HP:0002200)1.47547443
197Abnormal ossification of hand bones (HP:0005921)1.47451877

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK8.00850151
2TLK16.35243769
3TESK25.08868475
4MKNK24.97345879
5TNIK3.28334815
6TESK13.15244826
7MKNK12.81693103
8BUB12.73690492
9CDK192.52537051
10TRIB32.51151386
11ARAF2.49766473
12MUSK2.47076744
13SMG12.26523905
14VRK22.17656877
15SRPK12.16260523
16EPHA22.05879600
17CDC71.99170533
18PHKG11.95388424
19PHKG21.95388424
20MAP2K71.94770282
21PRPF4B1.85292120
22LIMK11.73544430
23SIK31.71257548
24BRSK11.70626706
25ICK1.69943463
26BLK1.69409818
27SCYL21.64451274
28PIM21.62698083
29RIPK11.61059097
30SIK11.58821861
31FES1.52005794
32MAP3K111.51759064
33BCKDK1.50650354
34EPHA41.50287440
35PBK1.43596841
36DAPK11.43369381
37PDK21.36408612
38NTRK31.34974335
39MST1R1.34053865
40MAPKAPK31.29562881
41LRRK21.29473381
42STK161.28038770
43PKN11.27821968
44DYRK1A1.26664997
45LMTK21.18282180
46UHMK11.17765342
47NLK1.14850462
48TAOK21.13198360
49ERN11.12183906
50MAPK131.08861460
51STK391.08553754
52YES11.07741537
53OXSR11.07685291
54CDK71.05781994
55PRKD31.05550595
56PKN21.05263489
57MAP3K81.04853286
58SIK21.04593709
59EEF2K1.03790230
60PAK61.00322728
61PAK40.96168040
62IRAK20.95448524
63EPHB10.94704146
64MAP3K10.93297345
65IRAK30.92097122
66IRAK10.91220260
67CDK140.89829807
68TTK0.85159791
69PTK20.84856262
70EPHB20.84794386
71STK100.84713812
72CLK10.83661221
73CSNK1G10.83183069
74GRK70.82676646
75ABL20.81722438
76CDK150.80427201
77CDK180.79697082
78NME10.79532228
79NME20.79110080
80ADRBK20.77747587
81NEK10.77152680
82EIF2AK20.76168432
83ILK0.76145749
84CAMKK10.75895115
85AURKB0.73957179
86MAPKAPK50.73017396
87FGFR40.72752413
88BMPR1B0.71416243
89PLK10.71227721
90CCNB10.71056474
91CAMK10.69669183
92SGK4940.69652503
93SGK2230.69652503
94NTRK10.69548873
95EIF2AK10.69467363
96ATR0.68887698
97DYRK20.68228281
98VRK10.67824895
99RPS6KA40.66814957
100CDK40.66483505
101NEK60.66017648
102KDR0.65771683
103PRKD20.64380421
104CHEK20.63719428
105ALK0.62220916
106CAMK2B0.61762159
107CDK30.61757334
108CHEK10.59227037
109PDGFRA0.57913292
110RPS6KB20.57762650
111WNK10.56329774
112INSRR0.56009124
113DMPK0.55880128
114WEE10.54880682
115MAP2K20.53951878
116PRKAA20.53266684
117NTRK20.52650854
118DAPK20.52335736
119RAF10.51797356
120CDK50.51548488
121GRK10.51308684
122MINK10.51191535
123PAK10.50156002
124CAMKK20.49821770
125MAP2K40.48337184
126WNK40.48060428
127BMX0.46592021
128CAMK2A0.46390701
129SGK20.45603097
130RPS6KA50.45365430
131MTOR0.45286059
132PRKG10.45003067
133PRKCI0.44273021
134AKT20.44159570
135GRK50.43393293
136FGR0.43359542
137MET0.42737628
138PINK10.42650386
139AKT30.41390398
140DYRK30.39832470
141DAPK30.39569969
142LATS20.39177303
143MOS0.38768040
144RPS6KA20.38350337
145MAP3K40.38010577
146TNK20.37666767
147PIK3CG0.37665459
148STK380.37479042
149CDK80.37250801
150PNCK0.36353917
151CDK20.34786445
152CAMK2G0.34502485
153TRIM280.34124893
154SGK10.34077997
155ADRBK10.33154414
156STK110.32947296
157PRKCG0.32425144
158IRAK40.31661497
159MAPK110.31104921
160CSNK1G30.30737104
161BRAF0.30165281
162PRKACA0.30123257
163CSNK1G20.27553991
164MARK10.27494531
165AURKA0.26879120
166MARK20.26337546
167CSNK1A10.26194234
168ERBB20.25773274
169MAPK120.24897142
170PRKCE0.24371568
171CDK11A0.23111449
172CSNK1A1L0.21778616
173CAMK2D0.21389348
174BMPR20.21050814
175LYN0.20604970
176CAMK40.20405475
177CSNK1D0.20159941
178PRKCQ0.19828542
179ROCK20.19713177

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034103.47573996
2Mismatch repair_Homo sapiens_hsa034303.16154975
3Phototransduction_Homo sapiens_hsa047442.96524594
4Nicotine addiction_Homo sapiens_hsa050332.95592859
5Biosynthesis of amino acids_Homo sapiens_hsa012302.91872493
6Ribosome_Homo sapiens_hsa030102.86526642
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84372743
8Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.78824730
9Proteasome_Homo sapiens_hsa030502.69676267
10Sulfur relay system_Homo sapiens_hsa041222.62013551
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.61971250
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.50594790
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49887489
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.45111239
15Systemic lupus erythematosus_Homo sapiens_hsa053222.42898557
16Fanconi anemia pathway_Homo sapiens_hsa034602.33345924
17Pentose phosphate pathway_Homo sapiens_hsa000302.14312898
18Carbon metabolism_Homo sapiens_hsa012002.12901209
19Fatty acid elongation_Homo sapiens_hsa000622.12405517
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93597687
21Fructose and mannose metabolism_Homo sapiens_hsa000511.89476105
22Long-term depression_Homo sapiens_hsa047301.88426985
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84365605
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83820163
25Glutamatergic synapse_Homo sapiens_hsa047241.82310727
26Alcoholism_Homo sapiens_hsa050341.81515245
27Protein export_Homo sapiens_hsa030601.76960864
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74004787
29Morphine addiction_Homo sapiens_hsa050321.71439650
30Galactose metabolism_Homo sapiens_hsa000521.71092914
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68281902
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.65680993
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62847413
34Cell cycle_Homo sapiens_hsa041101.56815302
35GABAergic synapse_Homo sapiens_hsa047271.52809263
36Taste transduction_Homo sapiens_hsa047421.50836227
37Pyruvate metabolism_Homo sapiens_hsa006201.50599528
38Ether lipid metabolism_Homo sapiens_hsa005651.50445309
39Sphingolipid metabolism_Homo sapiens_hsa006001.50106308
40Homologous recombination_Homo sapiens_hsa034401.45913029
41Serotonergic synapse_Homo sapiens_hsa047261.45840631
42Oxidative phosphorylation_Homo sapiens_hsa001901.42069621
43Olfactory transduction_Homo sapiens_hsa047401.41279656
44RNA polymerase_Homo sapiens_hsa030201.36383417
45Melanogenesis_Homo sapiens_hsa049161.30542660
46Axon guidance_Homo sapiens_hsa043601.26580571
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22883719
48Calcium signaling pathway_Homo sapiens_hsa040201.22743471
49Vibrio cholerae infection_Homo sapiens_hsa051101.22719846
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22576501
51Basal cell carcinoma_Homo sapiens_hsa052171.22539923
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22216894
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19459854
54N-Glycan biosynthesis_Homo sapiens_hsa005101.16106892
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15587315
56Circadian entrainment_Homo sapiens_hsa047131.15500063
57Salivary secretion_Homo sapiens_hsa049701.15324231
58Arginine and proline metabolism_Homo sapiens_hsa003301.14072639
59Other glycan degradation_Homo sapiens_hsa005111.13414118
60One carbon pool by folate_Homo sapiens_hsa006701.12532096
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12037660
62Wnt signaling pathway_Homo sapiens_hsa043101.10229186
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06423726
64Arachidonic acid metabolism_Homo sapiens_hsa005901.05636221
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05630149
66Basal transcription factors_Homo sapiens_hsa030221.04728122
67RNA transport_Homo sapiens_hsa030131.04472800
68Glutathione metabolism_Homo sapiens_hsa004801.03996094
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02471575
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01654607
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.99868607
72Vitamin B6 metabolism_Homo sapiens_hsa007500.97647201
73Alzheimers disease_Homo sapiens_hsa050100.94980909
74Parkinsons disease_Homo sapiens_hsa050120.94776620
75Phenylalanine metabolism_Homo sapiens_hsa003600.93366375
76Histidine metabolism_Homo sapiens_hsa003400.92739606
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90282227
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.89054172
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85406751
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.84635682
81Huntingtons disease_Homo sapiens_hsa050160.84563425
82Prion diseases_Homo sapiens_hsa050200.84280888
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.81660891
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81403341
85Spliceosome_Homo sapiens_hsa030400.80159806
86Hedgehog signaling pathway_Homo sapiens_hsa043400.79430568
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77838894
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77426138
89Bladder cancer_Homo sapiens_hsa052190.77047093
90Steroid biosynthesis_Homo sapiens_hsa001000.75563280
91Dopaminergic synapse_Homo sapiens_hsa047280.75286210
92Oocyte meiosis_Homo sapiens_hsa041140.75003304
93Amphetamine addiction_Homo sapiens_hsa050310.74850801
94Long-term potentiation_Homo sapiens_hsa047200.73759009
95mRNA surveillance pathway_Homo sapiens_hsa030150.73081377
96Non-small cell lung cancer_Homo sapiens_hsa052230.71709681
97Cholinergic synapse_Homo sapiens_hsa047250.70692779
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.68302326
99ABC transporters_Homo sapiens_hsa020100.67677736
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66885341
101Pyrimidine metabolism_Homo sapiens_hsa002400.66854942
102beta-Alanine metabolism_Homo sapiens_hsa004100.66254010
103Fatty acid metabolism_Homo sapiens_hsa012120.65708537
104Purine metabolism_Homo sapiens_hsa002300.64737531
105Chronic myeloid leukemia_Homo sapiens_hsa052200.64615641
106Shigellosis_Homo sapiens_hsa051310.64063406
107DNA replication_Homo sapiens_hsa030300.63340912
108Insulin secretion_Homo sapiens_hsa049110.63233837
109GnRH signaling pathway_Homo sapiens_hsa049120.62682629
110Circadian rhythm_Homo sapiens_hsa047100.61623155
111Synaptic vesicle cycle_Homo sapiens_hsa047210.61444116
112Regulation of autophagy_Homo sapiens_hsa041400.60362860
113Thyroid cancer_Homo sapiens_hsa052160.59123108
114Endocytosis_Homo sapiens_hsa041440.57980132
115Pancreatic cancer_Homo sapiens_hsa052120.56880983
116Arginine biosynthesis_Homo sapiens_hsa002200.55740968
117Renin secretion_Homo sapiens_hsa049240.55444937
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54272201
119Folate biosynthesis_Homo sapiens_hsa007900.53263908
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.51896970
121Cardiac muscle contraction_Homo sapiens_hsa042600.50483378
122Retinol metabolism_Homo sapiens_hsa008300.50240909
123Butanoate metabolism_Homo sapiens_hsa006500.49343386
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49276651
125Gap junction_Homo sapiens_hsa045400.48893368
126Lysine degradation_Homo sapiens_hsa003100.48393609
127Cocaine addiction_Homo sapiens_hsa050300.47569874
128Non-homologous end-joining_Homo sapiens_hsa034500.46169330
129cAMP signaling pathway_Homo sapiens_hsa040240.45904696
130AMPK signaling pathway_Homo sapiens_hsa041520.44849918
131Tyrosine metabolism_Homo sapiens_hsa003500.44822977
132Ras signaling pathway_Homo sapiens_hsa040140.44400812
133Epstein-Barr virus infection_Homo sapiens_hsa051690.42963359
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.42826105
135Glioma_Homo sapiens_hsa052140.42821244
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42734403
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42338657
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42284762
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41253271
140Metabolic pathways_Homo sapiens_hsa011000.40814159
141Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39898163
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39310259
143Gastric acid secretion_Homo sapiens_hsa049710.39146472
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36662735
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35565091
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35425555
147Insulin signaling pathway_Homo sapiens_hsa049100.35170673
148Linoleic acid metabolism_Homo sapiens_hsa005910.34810492
149Nucleotide excision repair_Homo sapiens_hsa034200.34652789
150Oxytocin signaling pathway_Homo sapiens_hsa049210.34323100
151Malaria_Homo sapiens_hsa051440.34285480
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34225185
153Peroxisome_Homo sapiens_hsa041460.33895021
154Collecting duct acid secretion_Homo sapiens_hsa049660.31511137
155Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31359660
156Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30613533
157Apoptosis_Homo sapiens_hsa042100.29174723
158Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29136480
159Fatty acid degradation_Homo sapiens_hsa000710.26875748
160Acute myeloid leukemia_Homo sapiens_hsa052210.26789680
161HTLV-I infection_Homo sapiens_hsa051660.26487176
162Endometrial cancer_Homo sapiens_hsa052130.26031129
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25939206
164Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23896956
165Glucagon signaling pathway_Homo sapiens_hsa049220.22508450
166Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19218703
167HIF-1 signaling pathway_Homo sapiens_hsa040660.18571431

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »