FNBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.09594752
2axon ensheathment in central nervous system (GO:0032291)8.09594752
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.22835601
4antigen processing and presentation of endogenous antigen (GO:0019883)5.17600297
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.04028860
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02358631
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80052329
8regulation of gamma-delta T cell activation (GO:0046643)4.68412710
9axon ensheathment (GO:0008366)4.62463845
10ensheathment of neurons (GO:0007272)4.62463845
11myelination (GO:0042552)4.60101237
12response to interleukin-15 (GO:0070672)4.47523015
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.40830427
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.40830427
15modulation by symbiont of host immune response (GO:0052553)4.40830427
16positive regulation by symbiont of host defense response (GO:0052509)4.40830427
17modulation by symbiont of host defense response (GO:0052031)4.40830427
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.40830427
19T cell migration (GO:0072678)4.39453591
20cellular response to interleukin-15 (GO:0071350)4.38874797
21CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.35296234
22positive regulation of B cell differentiation (GO:0045579)4.29658826
23regulation of gamma-delta T cell differentiation (GO:0045586)4.25091698
24myelin maintenance (GO:0043217)4.24033176
25long-chain fatty acid biosynthetic process (GO:0042759)4.09683558
26regulation of B cell differentiation (GO:0045577)4.00965836
27immunoglobulin mediated immune response (GO:0016064)3.96649629
28L-amino acid import (GO:0043092)3.94858389
29negative regulation of T cell mediated immunity (GO:0002710)3.93117091
30interferon-gamma-mediated signaling pathway (GO:0060333)3.91529457
31response to type I interferon (GO:0034340)3.87490173
32detection of bacterium (GO:0016045)3.86793307
33cellular response to type I interferon (GO:0071357)3.86499868
34type I interferon signaling pathway (GO:0060337)3.86499868
35response to muramyl dipeptide (GO:0032495)3.85403129
36detection of other organism (GO:0098543)3.77819979
37B cell homeostasis (GO:0001782)3.77142466
38fatty acid elongation (GO:0030497)3.71399526
39defense response to protozoan (GO:0042832)3.62443867
40NIK/NF-kappaB signaling (GO:0038061)3.57882356
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.55734463
42response to lipoprotein particle (GO:0055094)3.55297665
43negative regulation of neurotransmitter secretion (GO:0046929)3.54806592
44response to protozoan (GO:0001562)3.48934788
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.48542089
46negative regulation of interleukin-12 production (GO:0032695)3.42698265
47macrophage activation involved in immune response (GO:0002281)3.40420030
48negative regulation of neurotransmitter transport (GO:0051589)3.40291194
49germinal center formation (GO:0002467)3.38898890
50antigen receptor-mediated signaling pathway (GO:0050851)3.35204106
51T cell costimulation (GO:0031295)3.30372084
52lymphocyte costimulation (GO:0031294)3.28412781
53myeloid dendritic cell activation (GO:0001773)3.27965447
54regulation of interferon-beta biosynthetic process (GO:0045357)3.27311976
55response to peptidoglycan (GO:0032494)3.25662375
56B cell mediated immunity (GO:0019724)3.23609009
57negative regulation of erythrocyte differentiation (GO:0045647)3.22319095
58negative thymic T cell selection (GO:0045060)3.21687835
59negative T cell selection (GO:0043383)3.20978853
60regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.18799608
61regulation of natural killer cell mediated immunity (GO:0002715)3.18799608
62T-helper 1 type immune response (GO:0042088)3.17955383
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17712285
64response to host immune response (GO:0052572)3.17712285
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.17115789
66negative regulation of leukocyte mediated immunity (GO:0002704)3.16635000
67B cell proliferation (GO:0042100)3.13034852
68positive regulation of granulocyte differentiation (GO:0030854)3.12151644
69negative regulation of protein localization to cell surface (GO:2000009)3.11876814
70mucosal-associated lymphoid tissue development (GO:0048537)3.11497383
71Peyers patch development (GO:0048541)3.11497383
72positive regulation of humoral immune response (GO:0002922)3.10468571
73regulation of antigen processing and presentation (GO:0002577)3.10231556
74positive regulation of B cell activation (GO:0050871)3.10180005
75regulation of B cell proliferation (GO:0030888)3.09807108
76creatine metabolic process (GO:0006600)3.08823792
77oligodendrocyte differentiation (GO:0048709)3.08362825
78positive regulation of B cell proliferation (GO:0030890)3.08278316
79import into cell (GO:0098657)3.08092512
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06516151
81regulation of T cell mediated cytotoxicity (GO:0001914)3.01336888
82lymphocyte homeostasis (GO:0002260)2.99350382
83nerve growth factor signaling pathway (GO:0038180)2.97270009
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.96987137
85cellular extravasation (GO:0045123)2.96759911
86detection of external biotic stimulus (GO:0098581)2.96101431
87regulation of alpha-beta T cell activation (GO:0046634)2.96022702
88positive regulation of interferon-alpha production (GO:0032727)2.95906416
89positive regulation of B cell mediated immunity (GO:0002714)2.95856188
90positive regulation of immunoglobulin mediated immune response (GO:0002891)2.95856188
91T cell lineage commitment (GO:0002360)2.95531705
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.94795601
93response to host (GO:0075136)2.94795601
94response to host defenses (GO:0052200)2.94795601
95positive regulation of interleukin-4 production (GO:0032753)2.89727136
96adult walking behavior (GO:0007628)2.89403757
97positive regulation of gamma-delta T cell activation (GO:0046645)2.88485045
98mast cell activation (GO:0045576)2.84278560
99amino acid import (GO:0043090)2.83056008
100regulation of collateral sprouting (GO:0048670)2.80759415
101membrane raft organization (GO:0031579)2.80226505
102membrane tubulation (GO:0097320)2.78716376
103amyloid precursor protein metabolic process (GO:0042982)2.78461214
104Golgi to endosome transport (GO:0006895)2.78088481
105astrocyte development (GO:0014002)2.77259647
106activated T cell proliferation (GO:0050798)2.76801290
107neutrophil activation involved in immune response (GO:0002283)2.75725362
108positive regulation of interleukin-17 production (GO:0032740)2.74537913
109establishment of mitochondrion localization (GO:0051654)2.69255685
110peptidyl-tyrosine autophosphorylation (GO:0038083)2.67439358
111positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.66932088
112positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.63290938
113glycine transport (GO:0015816)2.62895655
114glycosylceramide metabolic process (GO:0006677)2.59951574
115photoreceptor cell differentiation (GO:0046530)2.57742480
116eye photoreceptor cell differentiation (GO:0001754)2.57742480
117positive thymic T cell selection (GO:0045059)2.55740310
118cortical actin cytoskeleton organization (GO:0030866)2.55432015
119regulation of T cell tolerance induction (GO:0002664)2.55214926
120regulation of memory T cell differentiation (GO:0043380)2.53226828
121tolerance induction (GO:0002507)2.53064382
122regulation of beta-amyloid formation (GO:1902003)2.51564128
123regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.51552564
124thymic T cell selection (GO:0045061)2.50001930
125positive regulation of interleukin-2 production (GO:0032743)2.49226604
126regulation of dendritic cell antigen processing and presentation (GO:0002604)2.49024852
127histone H3-K4 trimethylation (GO:0080182)2.48814215
128negative regulation of cell killing (GO:0031342)2.47985368
129negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47985368
130negative regulation of execution phase of apoptosis (GO:1900118)2.47234207
131regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.47146580
132positive regulation of T cell cytokine production (GO:0002726)2.45194017
133peripheral nervous system axon ensheathment (GO:0032292)2.44814880
134myelination in peripheral nervous system (GO:0022011)2.44814880
135regulation of ARF GTPase activity (GO:0032312)2.44800047
136neutrophil activation (GO:0042119)2.44259154
137positive regulation of T-helper cell differentiation (GO:0045624)2.42603831
138positive regulation of type 2 immune response (GO:0002830)2.42330144
139T cell selection (GO:0045058)2.40417833
140B cell receptor signaling pathway (GO:0050853)2.40410919
141regulation of interleukin-13 production (GO:0032656)2.39824235
142neuronal action potential propagation (GO:0019227)2.39801980
143presynaptic membrane organization (GO:0097090)2.38667854
144leukocyte aggregation (GO:0070486)2.38474051
145response to methylmercury (GO:0051597)2.38349673
146regulation of T-helper cell differentiation (GO:0045622)2.37537448
147regulation of ARF protein signal transduction (GO:0032012)2.37309076
148regulation of interleukin-12 biosynthetic process (GO:0045075)2.36352283
149mast cell activation involved in immune response (GO:0002279)2.35537699
150mast cell degranulation (GO:0043303)2.35537699
151cortical cytoskeleton organization (GO:0030865)2.34344665
152regulation of interleukin-4 production (GO:0032673)2.34201413
153positive regulation of antigen processing and presentation (GO:0002579)2.33898985
154regulation of interleukin-17 production (GO:0032660)2.32747225
155potassium ion import (GO:0010107)2.32535857
156regulation of interleukin-2 biosynthetic process (GO:0045076)2.31836959
157detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.31286770
158detection of temperature stimulus involved in sensory perception (GO:0050961)2.31286770
159negative regulation of macroautophagy (GO:0016242)2.30460530
160regulation of alpha-beta T cell proliferation (GO:0046640)2.30367854
161synaptic vesicle maturation (GO:0016188)2.29318936
162positive regulation of macrophage cytokine production (GO:0060907)2.28842881
163regulation of amyloid precursor protein catabolic process (GO:1902991)2.27603104
164amyloid precursor protein catabolic process (GO:0042987)2.25976346
165asymmetric protein localization (GO:0008105)2.25601189
166cerebellar granule cell differentiation (GO:0021707)2.25457112
167myeloid dendritic cell differentiation (GO:0043011)2.25083269
168regulation of T-helper 2 cell differentiation (GO:0045628)2.24364425
169positive T cell selection (GO:0043368)2.22890380
170positive regulation of Rap GTPase activity (GO:0032854)2.21795038
171granulocyte activation (GO:0036230)2.19717487
172interferon-gamma production (GO:0032609)2.19704791
173positive regulation of alpha-beta T cell proliferation (GO:0046641)2.18941224
174regulation of B cell receptor signaling pathway (GO:0050855)2.18612723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.32715137
2MYC_22102868_ChIP-Seq_BL_Human3.90678238
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.46720174
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.76134645
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.65797773
6MYB_26560356_Chip-Seq_TH1_Human2.55331796
7RUNX_20019798_ChIP-Seq_JUKART_Human2.47760048
8UTX_26944678_Chip-Seq_JUKART_Human2.37390065
9SPI1_23547873_ChIP-Seq_NB4_Human2.32157253
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.20092313
11TCF7_22412390_ChIP-Seq_EML_Mouse2.12788412
12AR_21572438_ChIP-Seq_LNCaP_Human2.11787257
13DROSHA_22980978_ChIP-Seq_HELA_Human2.10223541
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08947384
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.08945589
16MAF_26560356_Chip-Seq_TH2_Human2.07489083
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04318287
18* IRF8_27001747_Chip-Seq_BMDM_Mouse1.98452959
19RUNX1_22412390_ChIP-Seq_EML_Mouse1.94995423
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.93293153
21* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89652746
22BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89641888
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82293157
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.82290930
25* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80996478
26GBX2_23144817_ChIP-Seq_PC3_Human1.79846532
27CIITA_25753668_ChIP-Seq_RAJI_Human1.78780172
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73717163
29SCL_19346495_ChIP-Seq_HPC-7_Human1.71569721
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68380348
31SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68027597
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66856720
33GATA1_22025678_ChIP-Seq_K562_Human1.65400080
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65145729
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59307428
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57255050
37* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.57224115
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55737957
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54762068
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54634717
41GATA3_26560356_Chip-Seq_TH2_Human1.53165132
42* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51966508
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51203397
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.51001959
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50437702
46* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46607669
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46439841
48SPI1_23127762_ChIP-Seq_K562_Human1.45555043
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45454810
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45454810
51EZH2_22144423_ChIP-Seq_EOC_Human1.45321243
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45154663
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41778434
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40165733
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39668850
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37868661
57SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33962551
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33117210
59* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32844075
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32756159
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31003557
62VDR_24787735_ChIP-Seq_THP-1_Human1.30561902
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.29720885
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29674280
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.27805170
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27239514
67* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26901237
68PU_27001747_Chip-Seq_BMDM_Mouse1.24087841
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.23810203
70* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22660094
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20413251
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.20090283
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19537556
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.18776137
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18437837
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18325529
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17941464
78* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17643437
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17513612
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16539174
81VDR_24763502_ChIP-Seq_THP-1_Human1.15505426
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15252716
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14624639
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14270458
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13121704
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13028535
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10447281
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09038320
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08368646
90LXR_22292898_ChIP-Seq_THP-1_Human1.08201185
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07419212
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07391164
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06391512
94KDM2B_26808549_Chip-Seq_DND41_Human1.06381820
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06221959
96GATA1_19941826_ChIP-Seq_K562_Human1.05881131
97AHR_22903824_ChIP-Seq_MCF-7_Human1.05788006
98* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05017917
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04802269
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04643661
101* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02962453
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02073251
103* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01559422
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00784703
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.00372584
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.00317257
107* MYB_26560356_Chip-Seq_TH2_Human1.00280618
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.98060525
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98021585
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97887753
111ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96827900
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96547584
113ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96150866
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95381575
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95251422
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.94733071
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94641866
118* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93905036
119EZH2_27304074_Chip-Seq_ESCs_Mouse0.93784776
120MAF_26560356_Chip-Seq_TH1_Human0.93582418
121* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93574474
122ER_23166858_ChIP-Seq_MCF-7_Human0.92954067
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.92951919
124BCL6_27268052_Chip-Seq_Bcells_Human0.91883877
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91647322
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91444472
127* STAT3_23295773_ChIP-Seq_U87_Human0.91240488
128TP53_16413492_ChIP-PET_HCT116_Human0.91104861
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90971385
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90388247
131KDM2B_26808549_Chip-Seq_K562_Human0.90226257
132EED_16625203_ChIP-ChIP_MESCs_Mouse0.89404671
133RXR_22108803_ChIP-Seq_LS180_Human0.87826508
134* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87551442
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87530202
136* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87308228
137TAF15_26573619_Chip-Seq_HEK293_Human0.87108677
138* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86989461
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86886983
140GATA3_27048872_Chip-Seq_THYMUS_Human0.86814713
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.86187313
142SMRT_27268052_Chip-Seq_Bcells_Human0.86144838
143* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85872122
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.85520774
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85089395
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84738215
147TCF4_23295773_ChIP-Seq_U87_Human0.84737964
148VDR_21846776_ChIP-Seq_THP-1_Human0.84648776
149* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84261386
150GATA2_19941826_ChIP-Seq_K562_Human0.83073175
151CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82597431
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.80464916
153* NCOR1_26117541_ChIP-Seq_K562_Human0.77095833
154* BCOR_27268052_Chip-Seq_Bcells_Human0.76690119
155SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73690035
156SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72737408
157GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69607156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.46723273
2MP0003690_abnormal_glial_cell2.91706402
3MP0001835_abnormal_antigen_presentation2.81082784
4MP0003724_increased_susceptibility_to2.58520512
5MP0005671_abnormal_response_to2.58301896
6MP0005387_immune_system_phenotype2.39961644
7MP0001790_abnormal_immune_system2.39961644
8MP0004510_myositis2.33173904
9MP0000685_abnormal_immune_system2.30627593
10MP0004859_abnormal_synaptic_plasticity2.24287367
11MP0006082_CNS_inflammation2.19631754
12MP0009046_muscle_twitch2.13002285
13MP0001348_abnormal_lacrimal_gland2.10411069
14MP0003880_abnormal_central_pattern2.10201255
15MP0003950_abnormal_plasma_membrane2.09055014
16MP0004885_abnormal_endolymph2.07413555
17MP0004742_abnormal_vestibular_system2.06170617
18MP0008569_lethality_at_weaning2.04243476
19MP0002272_abnormal_nervous_system1.99361133
20MP0010155_abnormal_intestine_physiology1.96770849
21MP0005409_darkened_coat_color1.96208284
22MP0005000_abnormal_immune_tolerance1.96145733
23MP0003329_amyloid_beta_deposits1.95657209
24MP0001486_abnormal_startle_reflex1.94654840
25MP0000703_abnormal_thymus_morphology1.90277008
26MP0001800_abnormal_humoral_immune1.87148861
27MP0004381_abnormal_hair_follicle1.87002610
28MP0004270_analgesia1.86432418
29MP0002722_abnormal_immune_system1.86308467
30MP0002064_seizures1.84880942
31MP0002429_abnormal_blood_cell1.84352729
32MP0005423_abnormal_somatic_nervous1.78605713
33MP0002396_abnormal_hematopoietic_system1.77305455
34MP0003634_abnormal_glial_cell1.76087195
35MP0001845_abnormal_inflammatory_respons1.74921494
36MP0002148_abnormal_hypersensitivity_rea1.73177031
37MP0002723_abnormal_immune_serum1.72498673
38MP0004142_abnormal_muscle_tone1.70214721
39MP0002138_abnormal_hepatobiliary_system1.66839236
40MP0003172_abnormal_lysosome_physiology1.65082517
41MP0000604_amyloidosis1.62930191
42MP0002452_abnormal_antigen_presenting1.61402683
43MP0002419_abnormal_innate_immunity1.58958998
44MP0002420_abnormal_adaptive_immunity1.56524945
45MP0001819_abnormal_immune_cell1.55982678
46MP0003763_abnormal_thymus_physiology1.54565178
47MP0005310_abnormal_salivary_gland1.53586744
48MP0000569_abnormal_digit_pigmentation1.50901017
49MP0005025_abnormal_response_to1.50706458
50MP0003635_abnormal_synaptic_transmissio1.50555357
51MP0003632_abnormal_nervous_system1.49560569
52MP0005058_abnormal_lysosome_morphology1.47267365
53MP0001851_eye_inflammation1.42228366
54MP0001533_abnormal_skeleton_physiology1.41931962
55MP0003633_abnormal_nervous_system1.41449884
56MP0000383_abnormal_hair_follicle1.40603692
57MP0009745_abnormal_behavioral_response1.40245366
58MP0003631_nervous_system_phenotype1.38674202
59MP0005171_absent_coat_pigmentation1.36639834
60MP0009278_abnormal_bone_marrow1.34217727
61MP0003303_peritoneal_inflammation1.34065842
62MP0008057_abnormal_DNA_replication1.29384365
63MP0001905_abnormal_dopamine_level1.27655918
64MP0005451_abnormal_body_composition1.27444863
65MP0004808_abnormal_hematopoietic_stem1.26187810
66MP0002229_neurodegeneration1.25319532
67MP0008469_abnormal_protein_level1.24253867
68MP0001853_heart_inflammation1.23311035
69MP0009785_altered_susceptibility_to1.22999585
70MP0000716_abnormal_immune_system1.21270004
71MP0010678_abnormal_skin_adnexa1.19527266
72MP0005174_abnormal_tail_pigmentation1.17072451
73MP0005075_abnormal_melanosome_morpholog1.16625761
74MP0002166_altered_tumor_susceptibility1.16499581
75MP0002405_respiratory_system_inflammati1.15703231
76MP0003045_fibrosis1.15301927
77MP0003300_gastrointestinal_ulcer1.14124163
78MP0001485_abnormal_pinna_reflex1.14111308
79MP0003136_yellow_coat_color1.13006130
80MP0005397_hematopoietic_system_phenotyp1.12288455
81MP0001545_abnormal_hematopoietic_system1.12288455
82MP0001970_abnormal_pain_threshold1.11241607
83MP0002398_abnormal_bone_marrow1.10839478
84MP0002734_abnormal_mechanical_nocicepti1.08620981
85MP0000778_abnormal_nervous_system1.08404896
86MP0002998_abnormal_bone_remodeling1.08080020
87MP0005464_abnormal_platelet_physiology1.07568301
88MP0002067_abnormal_sensory_capabilities1.07108090
89MP0001873_stomach_inflammation1.05818472
90MP0003866_abnormal_defecation1.05401631
91MP0002572_abnormal_emotion/affect_behav1.04705122
92MP0001346_abnormal_lacrimal_gland1.02650491
93MP0002735_abnormal_chemical_nociception1.01541950
94MP0002933_joint_inflammation1.01299663
95MP0000015_abnormal_ear_pigmentation1.01224276
96MP0009764_decreased_sensitivity_to1.00093504
97MP0000465_gastrointestinal_hemorrhage0.99182934
98MP0002063_abnormal_learning/memory/cond0.97289641
99MP0005645_abnormal_hypothalamus_physiol0.97084382
100MP0002009_preneoplasia0.95907461
101MP0001502_abnormal_circadian_rhythm0.95644198
102MP0000858_altered_metastatic_potential0.93001300
103MP0008260_abnormal_autophagy0.92617160
104MP0009333_abnormal_splenocyte_physiolog0.91984608
105MP0000955_abnormal_spinal_cord0.90750496
106MP0003075_altered_response_to0.89534804
107MP0004947_skin_inflammation0.88171907
108MP0009840_abnormal_foam_cell0.87796766
109MP0001440_abnormal_grooming_behavior0.87687502
110MP0002006_tumorigenesis0.86690104
111MP0003183_abnormal_peptide_metabolism0.86374568
112MP0002066_abnormal_motor_capabilities/c0.84801361
113MP0003436_decreased_susceptibility_to0.84676164
114MP0002733_abnormal_thermal_nociception0.84638617
115MP0004147_increased_porphyrin_level0.84605537
116MP0008874_decreased_physiological_sensi0.83463657
117MP0001501_abnormal_sleep_pattern0.82346632
118MP0005386_behavior/neurological_phenoty0.81998109
119MP0004924_abnormal_behavior0.81998109
120MP0000689_abnormal_spleen_morphology0.80801346
121MP0002019_abnormal_tumor_incidence0.80559094
122MP0003091_abnormal_cell_migration0.77863208
123MP0001663_abnormal_digestive_system0.74201432
124MP0005166_decreased_susceptibility_to0.72421024
125MP0009763_increased_sensitivity_to0.71741386
126MP0003828_pulmonary_edema0.71636649
127MP0000490_abnormal_crypts_of0.69750309
128MP0003191_abnormal_cellular_cholesterol0.67862130
129MP0009765_abnormal_xenobiotic_induced0.64719724
130MP0001986_abnormal_taste_sensitivity0.63968105
131MP0002163_abnormal_gland_morphology0.61303943
132MP0002693_abnormal_pancreas_physiology0.59118129
133MP0003448_altered_tumor_morphology0.57083771
134MP0008961_abnormal_basal_metabolism0.55589085
135MP0000249_abnormal_blood_vessel0.51884356
136MP0009115_abnormal_fat_cell0.51258796
137MP0005390_skeleton_phenotype0.50874032
138MP0003795_abnormal_bone_structure0.49564906
139MP0002928_abnormal_bile_duct0.49451927
140MP0005076_abnormal_cell_differentiation0.44718391
141MP0002132_abnormal_respiratory_system0.43865221
142MP0004883_abnormal_blood_vessel0.43665643
143MP0000609_abnormal_liver_physiology0.40172893
144MP0002136_abnormal_kidney_physiology0.39842335
145MP0005535_abnormal_body_temperature0.39432772
146MP0002083_premature_death0.39078671

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)4.97243348
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.53102572
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.53102572
4Peripheral hypomyelination (HP:0007182)4.29151631
5Supranuclear gaze palsy (HP:0000605)4.20037862
6Onion bulb formation (HP:0003383)4.09433968
7Recurrent bronchitis (HP:0002837)3.99409919
8Lymphopenia (HP:0001888)3.83820707
9Abnormality of T cells (HP:0002843)3.73063478
10Colitis (HP:0002583)3.67241722
11Abnormality of the corticospinal tract (HP:0002492)3.67016255
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.65270952
13Abnormality of cells of the lymphoid lineage (HP:0012140)3.63610034
14Recurrent sinusitis (HP:0011108)3.61569403
15IgA deficiency (HP:0002720)3.57803210
16IgG deficiency (HP:0004315)3.54157382
17Encephalitis (HP:0002383)3.53009316
18Parakeratosis (HP:0001036)3.48780144
19Increased IgE level (HP:0003212)3.48191632
20Gastrointestinal inflammation (HP:0004386)3.47824483
21IgM deficiency (HP:0002850)3.46507633
22Gastrointestinal infarctions (HP:0005244)3.42307949
23Stomatitis (HP:0010280)3.39233918
24Abnormality of T cell physiology (HP:0011840)3.39218397
25Slow saccadic eye movements (HP:0000514)3.39060927
26Autoimmune hemolytic anemia (HP:0001890)3.38399968
27Cerebral inclusion bodies (HP:0100314)3.35556972
28Chronic diarrhea (HP:0002028)3.34540011
29Segmental peripheral demyelination/remyelination (HP:0003481)3.28901307
30Abnormal auditory evoked potentials (HP:0006958)3.27419347
31Chronic otitis media (HP:0000389)3.19342021
32Increased IgM level (HP:0003496)3.11374047
33Intention tremor (HP:0002080)3.09827082
34Action tremor (HP:0002345)3.08423669
35Dysmetria (HP:0001310)3.04897050
36Chest pain (HP:0100749)3.03197675
37Spastic gait (HP:0002064)3.02471365
38Sensory axonal neuropathy (HP:0003390)3.02394318
39Emphysema (HP:0002097)2.99016447
40Abnormality of B cell number (HP:0010975)2.98313553
41B lymphocytopenia (HP:0010976)2.93671356
42Spontaneous hematomas (HP:0007420)2.92269243
43Scanning speech (HP:0002168)2.89370390
44Myokymia (HP:0002411)2.88971690
45Verrucae (HP:0200043)2.85118032
46Papilloma (HP:0012740)2.85118032
47Hemoptysis (HP:0002105)2.84678936
48Granulocytopenia (HP:0001913)2.83774502
49Recurrent abscess formation (HP:0002722)2.83072975
50Diplopia (HP:0000651)2.81995385
51Abnormality of binocular vision (HP:0011514)2.81995385
52Optic neuritis (HP:0100653)2.79474740
53Retrobulbar optic neuritis (HP:0100654)2.79474740
54Urticaria (HP:0001025)2.73156265
55Recurrent gram-negative bacterial infections (HP:0005420)2.72809821
56Keratoconjunctivitis sicca (HP:0001097)2.72411892
57Recurrent bacterial skin infections (HP:0005406)2.71011159
58Severe combined immunodeficiency (HP:0004430)2.69006653
59Pustule (HP:0200039)2.65235825
60Leukocytosis (HP:0001974)2.65111559
61Osteomyelitis (HP:0002754)2.63445988
62Eczematoid dermatitis (HP:0000976)2.62778445
63Ankle clonus (HP:0011448)2.61154295
64Axonal loss (HP:0003447)2.61063562
65Viral hepatitis (HP:0006562)2.57286820
66Autoimmune thrombocytopenia (HP:0001973)2.57133598
67Recurrent skin infections (HP:0001581)2.55482099
68Keratoconjunctivitis (HP:0001096)2.53316091
69Premature skin wrinkling (HP:0100678)2.51453167
70Recurrent lower respiratory tract infections (HP:0002783)2.50852921
71Hypergammaglobulinemia (HP:0010702)2.50712997
72Abnormality of T cell number (HP:0011839)2.47696223
73Termporal pattern (HP:0011008)2.46582995
74Insidious onset (HP:0003587)2.46582995
75Abnormality of the prostate (HP:0008775)2.45411605
76Abnormality of macrophages (HP:0004311)2.45201974
77Papilledema (HP:0001085)2.44881936
78Arterial thrombosis (HP:0004420)2.44721598
79Recurrent fungal infections (HP:0002841)2.44013262
80Sepsis (HP:0100806)2.43504994
81Abnormality of the pleura (HP:0002103)2.42444161
82Agammaglobulinemia (HP:0004432)2.42106107
83T lymphocytopenia (HP:0005403)2.41526474
84Lymphoma (HP:0002665)2.41230090
85Vasculitis (HP:0002633)2.40681572
86Recurrent pneumonia (HP:0006532)2.38835590
87Abnormality of eosinophils (HP:0001879)2.38648888
88Loss of speech (HP:0002371)2.35613126
89Clumsiness (HP:0002312)2.32814534
90Gastrointestinal stroma tumor (HP:0100723)2.31788508
91Fatigue (HP:0012378)2.30931490
92Chronic mucocutaneous candidiasis (HP:0002728)2.29463813
93Recurrent cutaneous fungal infections (HP:0011370)2.29463813
94Myositis (HP:0100614)2.28898064
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.28858241
96Increased cerebral lipofuscin (HP:0011813)2.28650963
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.28543452
98Panhypogammaglobulinemia (HP:0003139)2.28145706
99Gingivitis (HP:0000230)2.28063867
100Skin rash (HP:0000988)2.27568880
101Pulmonary embolism (HP:0002204)2.26503932
102Abnormality of the fingertips (HP:0001211)2.25873686
103Alacrima (HP:0000522)2.25600149
104Combined immunodeficiency (HP:0005387)2.25385270
105Prolonged bleeding time (HP:0003010)2.23238684
106Epistaxis (HP:0000421)2.22707830
107Cerebral hypomyelination (HP:0006808)2.21934881
108Basal cell carcinoma (HP:0002671)2.19984962
109Recurrent viral infections (HP:0004429)2.19845588
110Arthralgia (HP:0002829)2.19441554
111Obstructive lung disease (HP:0006536)2.17186412
112Chronic obstructive pulmonary disease (HP:0006510)2.17186412
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16954677
114Gangrene (HP:0100758)2.15022562
115Decreased motor nerve conduction velocity (HP:0003431)2.12757311
116Meningitis (HP:0001287)2.09947337
117Bronchitis (HP:0012387)2.09435628
118Orchitis (HP:0100796)2.08888728
119Elevated erythrocyte sedimentation rate (HP:0003565)2.08315242
120Joint swelling (HP:0001386)2.08246132
121Skin ulcer (HP:0200042)2.06247836
122Spastic tetraparesis (HP:0001285)2.05946819
123Hypertensive crisis (HP:0100735)2.05556317
124Cellulitis (HP:0100658)2.04853305
125Amaurosis fugax (HP:0100576)2.04478531
126Foot dorsiflexor weakness (HP:0009027)2.04120377
127Abnormality of the peritoneum (HP:0002585)2.03922410
128Abnormality of saccadic eye movements (HP:0000570)2.02151868
129Neuronal loss in central nervous system (HP:0002529)2.01864364
130Premature loss of primary teeth (HP:0006323)2.01602975
131White forelock (HP:0002211)2.01125752
132Hepatosplenomegaly (HP:0001433)2.00374796
133Lower limb muscle weakness (HP:0007340)2.00365327
134Acrocyanosis (HP:0001063)1.99047279
135Metabolic alkalosis (HP:0200114)1.98425311
136Macroorchidism (HP:0000053)1.96141013
137Abnormal delayed hypersensitivity skin test (HP:0002963)1.95153086
138Hypochromic anemia (HP:0001931)1.95121046
139Ectropion (HP:0000656)1.93536265
140Hypoplasia of the iris (HP:0007676)1.93148884
141Abnormality of liposaccharide metabolism (HP:0010968)1.89962158
142Abnormality of glycosphingolipid metabolism (HP:0004343)1.89962158
143Abnormality of glycolipid metabolism (HP:0010969)1.89962158
144Urinary urgency (HP:0000012)1.88613589
145Pulmonary infiltrates (HP:0002113)1.87691369
146Decreased lacrimation (HP:0000633)1.87194513
147Anteriorly placed anus (HP:0001545)1.86535026
148Peripheral demyelination (HP:0011096)1.86031171
149Abnormality of the foot musculature (HP:0001436)1.85725340
150Thickened helices (HP:0000391)1.85087169
151Restrictive lung disease (HP:0002091)1.84085906
152Mediastinal lymphadenopathy (HP:0100721)1.82235782
153Gingival bleeding (HP:0000225)1.81540868
154Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.80936473
155Progressive cerebellar ataxia (HP:0002073)1.80570415
156Gaze-evoked nystagmus (HP:0000640)1.79740466
157Hemiplegia (HP:0002301)1.79611549
158Inflammation of the large intestine (HP:0002037)1.79596746
159Morphological abnormality of the inner ear (HP:0011390)1.79396050
160Patchy hypopigmentation of hair (HP:0011365)1.77637030
161Megalencephaly (HP:0001355)1.75943942
162Stridor (HP:0010307)1.75227449
163Urinary bladder sphincter dysfunction (HP:0002839)1.72061719
164Widely spaced teeth (HP:0000687)1.71625881
165Absent septum pellucidum (HP:0001331)1.70631396
166Vertigo (HP:0002321)1.70359896
167Eosinophilia (HP:0001880)1.67733248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.04884657
2PRPF4B4.01074254
3STK393.73756415
4MAP4K12.67931538
5PKN12.62493362
6OXSR12.49192130
7WNK12.28401011
8TXK2.21607278
9MAPKAPK52.20099893
10TAOK32.08949231
11MAP3K142.05430879
12ERN11.91801193
13MAP3K131.72221982
14ITK1.67074353
15CDK121.47395397
16CLK11.47329314
17SIK31.44744737
18RIPK41.41674774
19CDK191.41034265
20SMG11.37943160
21FGFR21.30566023
22SGK4941.29198849
23SGK2231.29198849
24GRK61.28830594
25ROCK21.27867695
26JAK11.27828906
27MAP2K31.27392734
28FGFR41.26783671
29UHMK11.26044954
30IKBKB1.22408284
31BCR1.21804948
32NEK91.19851534
33CSNK1A1L1.18401847
34PRKCQ1.18067851
35TRPM71.17455974
36KIT1.17349281
37HCK1.16174519
38PRKCH1.15996290
39MARK21.14652729
40CAMK1G1.14096626
41CSF1R1.13529166
42NEK61.13528336
43FES1.11627839
44IRAK41.10643526
45NTRK11.08332391
46IKBKE1.07720790
47SIK21.07082938
48SYK1.06590259
49LCK1.02295645
50JAK31.01768795
51BTK1.00493902
52FGR0.96285741
53CAMKK10.95761065
54BLK0.95579808
55CDC42BPA0.92914417
56MATK0.92426586
57PAK60.92176726
58TYK20.92041458
59MARK30.92012802
60TRIB30.91438464
61YES10.90722612
62MAP3K100.90651792
63CAMK2B0.90169077
64TNIK0.89751735
65CDK40.89608067
66DMPK0.89537477
67MAPK120.89131802
68NTRK20.88218295
69MAPK110.87085266
70TNK20.87039004
71PRKD10.85699668
72PASK0.85187799
73MST40.83874896
74LIMK10.83782725
75WNK40.83507082
76CSNK1G30.82444618
77CSK0.80454376
78PIM10.78755786
79HIPK20.75895982
80CDK50.75834745
81ZAP700.74968762
82TBK10.72712799
83FYN0.70641162
84CAMK2D0.70497798
85BMPR20.69690546
86PDK10.67544244
87STK110.67231423
88TESK20.66748184
89KSR20.65073159
90TAOK20.64972747
91CSNK1G20.64103879
92PDPK10.63456535
93CSNK1G10.62764518
94ALK0.62035048
95CAMK2G0.61920969
96MAP3K70.61261585
97MAP3K10.60285180
98MET0.59693387
99STK100.59099925
100SGK30.59078226
101IRAK10.58205120
102PHKG20.58079443
103PHKG10.58079443
104PNCK0.57056501
105PRKD20.56818490
106CAMKK20.55858968
107NLK0.55429606
108PDGFRB0.54755038
109MAP3K110.53916040
110MAPK70.53369593
111CAMK1D0.53147523
112TYRO30.52779546
113EEF2K0.50946104
114TEC0.50785026
115MAPK40.49876122
116JAK20.49109256
117PRKG10.48898277
118PRKCE0.48469309
119GSK3A0.48363947
120BRD40.47184664
121EPHA30.45303170
122SGK20.45271716
123LRRK20.45108343
124BMX0.44543160
125SGK10.44422632
126MELK0.43278453
127CHUK0.42894479
128GRK70.42652908
129LYN0.41902177
130ABL10.41369068
131MAPK100.41202334
132FGFR30.40739558
133MAPKAPK20.40596749
134IRAK20.36968680
135TAOK10.36866139
136RPS6KL10.33614998
137RPS6KC10.33614998
138DAPK20.33528356
139RAF10.31300147
140PIK3CG0.31181549
141MAP2K20.29307178
142SIK10.29275053
143ARAF0.29109250
144RPS6KA60.28059760
145MAPK30.26820848

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.22318997
2Antigen processing and presentation_Homo sapiens_hsa046122.17874041
3Allograft rejection_Homo sapiens_hsa053302.12042480
4Staphylococcus aureus infection_Homo sapiens_hsa051501.98113139
5Autoimmune thyroid disease_Homo sapiens_hsa053201.95067183
6B cell receptor signaling pathway_Homo sapiens_hsa046621.77281757
7Influenza A_Homo sapiens_hsa051641.74453325
8Graft-versus-host disease_Homo sapiens_hsa053321.74087997
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74080102
10Fatty acid elongation_Homo sapiens_hsa000621.73779250
11Ether lipid metabolism_Homo sapiens_hsa005651.72269208
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.71547317
13Herpes simplex infection_Homo sapiens_hsa051681.71301248
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69199783
15T cell receptor signaling pathway_Homo sapiens_hsa046601.68157206
16Steroid biosynthesis_Homo sapiens_hsa001001.59337035
17Chemokine signaling pathway_Homo sapiens_hsa040621.51503944
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.49869957
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48775764
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48485900
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45910270
22Glutamatergic synapse_Homo sapiens_hsa047241.45638293
23Osteoclast differentiation_Homo sapiens_hsa043801.45554836
24Acute myeloid leukemia_Homo sapiens_hsa052211.43716853
25Hepatitis B_Homo sapiens_hsa051611.30619669
26Asthma_Homo sapiens_hsa053101.29226727
27Leishmaniasis_Homo sapiens_hsa051401.26627748
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26523186
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25003570
30Morphine addiction_Homo sapiens_hsa050321.24991671
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23927927
32Sphingolipid signaling pathway_Homo sapiens_hsa040711.17922279
33Epstein-Barr virus infection_Homo sapiens_hsa051691.16603131
34Sphingolipid metabolism_Homo sapiens_hsa006001.16254054
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14009334
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10147913
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.10130759
38GABAergic synapse_Homo sapiens_hsa047271.09835930
39Long-term depression_Homo sapiens_hsa047301.08863735
40Malaria_Homo sapiens_hsa051441.08782569
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08275027
42Measles_Homo sapiens_hsa051621.07075239
43Non-small cell lung cancer_Homo sapiens_hsa052231.06902642
44Rheumatoid arthritis_Homo sapiens_hsa053231.05401069
45Axon guidance_Homo sapiens_hsa043601.04835366
46Gastric acid secretion_Homo sapiens_hsa049711.04740826
47Endocytosis_Homo sapiens_hsa041441.04452413
48Salivary secretion_Homo sapiens_hsa049701.04350598
49Dorso-ventral axis formation_Homo sapiens_hsa043201.04111364
50Hepatitis C_Homo sapiens_hsa051601.03521918
51Apoptosis_Homo sapiens_hsa042101.03090448
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.02622262
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02600818
54Nitrogen metabolism_Homo sapiens_hsa009101.01567738
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99343067
56Hematopoietic cell lineage_Homo sapiens_hsa046400.99155624
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98227018
58Circadian entrainment_Homo sapiens_hsa047130.95847047
59Lysosome_Homo sapiens_hsa041420.95501201
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95277624
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93612173
62Inositol phosphate metabolism_Homo sapiens_hsa005620.92866961
63Serotonergic synapse_Homo sapiens_hsa047260.91818248
64Renal cell carcinoma_Homo sapiens_hsa052110.90624388
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90142301
66Salmonella infection_Homo sapiens_hsa051320.89901566
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.88604033
68Prolactin signaling pathway_Homo sapiens_hsa049170.87474051
69HTLV-I infection_Homo sapiens_hsa051660.87260154
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87009043
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86197751
72MAPK signaling pathway_Homo sapiens_hsa040100.86043457
73Chronic myeloid leukemia_Homo sapiens_hsa052200.85426422
74ErbB signaling pathway_Homo sapiens_hsa040120.83986013
75Pertussis_Homo sapiens_hsa051330.83457369
76Olfactory transduction_Homo sapiens_hsa047400.83401543
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82838305
78Ras signaling pathway_Homo sapiens_hsa040140.80744126
79Toxoplasmosis_Homo sapiens_hsa051450.80558269
80Cholinergic synapse_Homo sapiens_hsa047250.79951753
81Viral carcinogenesis_Homo sapiens_hsa052030.79815238
82Platelet activation_Homo sapiens_hsa046110.79401026
83VEGF signaling pathway_Homo sapiens_hsa043700.78976636
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78680639
85cAMP signaling pathway_Homo sapiens_hsa040240.77353279
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77237222
87Tuberculosis_Homo sapiens_hsa051520.76969308
88Nicotine addiction_Homo sapiens_hsa050330.76620649
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76506223
90Renin secretion_Homo sapiens_hsa049240.76189249
91African trypanosomiasis_Homo sapiens_hsa051430.75356952
92Shigellosis_Homo sapiens_hsa051310.72582239
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72067066
94Legionellosis_Homo sapiens_hsa051340.71830542
95Cocaine addiction_Homo sapiens_hsa050300.70849060
96Choline metabolism in cancer_Homo sapiens_hsa052310.70169344
97Viral myocarditis_Homo sapiens_hsa054160.69581794
98Long-term potentiation_Homo sapiens_hsa047200.69393447
99Phagosome_Homo sapiens_hsa041450.67786407
100Taste transduction_Homo sapiens_hsa047420.67084586
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.65440527
102Vitamin B6 metabolism_Homo sapiens_hsa007500.65052602
103Type I diabetes mellitus_Homo sapiens_hsa049400.64759510
104Systemic lupus erythematosus_Homo sapiens_hsa053220.62460451
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.61784394
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61633031
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61131798
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61091501
109Pancreatic secretion_Homo sapiens_hsa049720.60975941
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60632020
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59728028
112Calcium signaling pathway_Homo sapiens_hsa040200.58116855
113Pancreatic cancer_Homo sapiens_hsa052120.57984891
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57770735
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57496140
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56824222
117Oxytocin signaling pathway_Homo sapiens_hsa049210.55592246
118Rap1 signaling pathway_Homo sapiens_hsa040150.54442092
119TNF signaling pathway_Homo sapiens_hsa046680.53286368
120Dopaminergic synapse_Homo sapiens_hsa047280.52793379
121Type II diabetes mellitus_Homo sapiens_hsa049300.51716652
122Other glycan degradation_Homo sapiens_hsa005110.50467816
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50269012
124Colorectal cancer_Homo sapiens_hsa052100.49307846
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48331366
126GnRH signaling pathway_Homo sapiens_hsa049120.46355258
127mTOR signaling pathway_Homo sapiens_hsa041500.43687365
128FoxO signaling pathway_Homo sapiens_hsa040680.43671797
129Prostate cancer_Homo sapiens_hsa052150.43597296
130Endometrial cancer_Homo sapiens_hsa052130.42834437
131HIF-1 signaling pathway_Homo sapiens_hsa040660.39112807
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.38479265
133Glioma_Homo sapiens_hsa052140.33199602
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33094594
135Insulin resistance_Homo sapiens_hsa049310.32290962
136Notch signaling pathway_Homo sapiens_hsa043300.30841984
137Small cell lung cancer_Homo sapiens_hsa052220.26834132
138Estrogen signaling pathway_Homo sapiens_hsa049150.23919568
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23671135

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