FNBP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.89844199
2layer formation in cerebral cortex (GO:0021819)5.77365688
3nucleobase catabolic process (GO:0046113)5.62134516
4cell migration in hindbrain (GO:0021535)5.05282510
5central nervous system projection neuron axonogenesis (GO:0021952)4.96505252
6vocalization behavior (GO:0071625)4.71936846
7axonal fasciculation (GO:0007413)4.69265259
8dendritic spine morphogenesis (GO:0060997)4.59438391
9neuron cell-cell adhesion (GO:0007158)4.58638459
10neuron recognition (GO:0008038)4.56072705
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.54581963
12dendrite morphogenesis (GO:0048813)4.52333285
13presynaptic membrane organization (GO:0097090)4.29044978
14regulation of synapse structural plasticity (GO:0051823)4.11912057
15protein localization to synapse (GO:0035418)4.10354865
16regulation of glutamate receptor signaling pathway (GO:1900449)4.09999098
17locomotory exploration behavior (GO:0035641)4.09462154
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.99198933
19auditory behavior (GO:0031223)3.98640163
20axon extension (GO:0048675)3.98110705
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96437560
22synaptic vesicle maturation (GO:0016188)3.89684091
23postsynaptic membrane organization (GO:0001941)3.78104834
24establishment of mitochondrion localization (GO:0051654)3.73361816
25central nervous system neuron axonogenesis (GO:0021955)3.72226283
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71793863
27clathrin coat assembly (GO:0048268)3.68859440
28positive regulation of synapse maturation (GO:0090129)3.65362017
29exploration behavior (GO:0035640)3.64963381
30positive regulation of dendritic spine morphogenesis (GO:0061003)3.51862208
31establishment of nucleus localization (GO:0040023)3.51523090
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.51028625
33neuron projection extension (GO:1990138)3.50219302
34limb bud formation (GO:0060174)3.49204662
35neurotransmitter-gated ion channel clustering (GO:0072578)3.44298484
36cerebral cortex radially oriented cell migration (GO:0021799)3.44189175
37proline transport (GO:0015824)3.44135402
38regulation of cAMP-dependent protein kinase activity (GO:2000479)3.42658294
39regulation of dendritic spine morphogenesis (GO:0061001)3.39922265
40calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.39377707
41glial cell proliferation (GO:0014009)3.34921993
42response to auditory stimulus (GO:0010996)3.31500652
43synaptic vesicle exocytosis (GO:0016079)3.27283083
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.24586186
45retinal ganglion cell axon guidance (GO:0031290)3.22885479
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.19487137
47neuron migration (GO:0001764)3.18759517
48regulation of synaptic vesicle exocytosis (GO:2000300)3.15957424
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11280376
50hippocampus development (GO:0021766)3.11057039
51regulation of axon guidance (GO:1902667)3.08819009
52cerebellum development (GO:0021549)3.07150603
53dopamine receptor signaling pathway (GO:0007212)3.06364041
54regulation of axon extension involved in axon guidance (GO:0048841)3.04752145
55mechanosensory behavior (GO:0007638)3.02846915
56positive regulation of axon extension (GO:0045773)3.02684397
57glutamate secretion (GO:0014047)3.02039897
58adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.01226361
59negative regulation of microtubule polymerization (GO:0031115)2.99068847
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97392166
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95944094
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94235531
63regulation of synapse maturation (GO:0090128)2.88872499
64synapse assembly (GO:0007416)2.88835489
65dendrite development (GO:0016358)2.87061348
66gamma-aminobutyric acid transport (GO:0015812)2.86664284
67nonmotile primary cilium assembly (GO:0035058)2.86400482
68negative regulation of axon guidance (GO:1902668)2.85348548
69response to pheromone (GO:0019236)2.84513507
70positive regulation of synapse assembly (GO:0051965)2.83424502
71positive regulation of mitochondrial fission (GO:0090141)2.83275784
72regulation of axon extension (GO:0030516)2.82797423
73olfactory bulb development (GO:0021772)2.81777611
74regulation of neuronal synaptic plasticity (GO:0048168)2.81048715
75prepulse inhibition (GO:0060134)2.80399060
76regulation of synapse organization (GO:0050807)2.80151009
77synaptic transmission, glutamatergic (GO:0035249)2.78249585
78regulation of NFAT protein import into nucleus (GO:0051532)2.77225543
79dendritic spine organization (GO:0097061)2.76794988
80glutamate receptor signaling pathway (GO:0007215)2.76270120
81regulation of synapse assembly (GO:0051963)2.75119415
82negative regulation of axon extension involved in axon guidance (GO:0048843)2.73354783
83presynaptic membrane assembly (GO:0097105)2.72116512
84neurofilament cytoskeleton organization (GO:0060052)2.71843942
85neurotransmitter secretion (GO:0007269)2.71567446
86regulation of dendritic spine development (GO:0060998)2.70666852
87negative regulation of catenin import into nucleus (GO:0035414)2.70624713
88neural tube formation (GO:0001841)2.70608105
89* positive regulation of filopodium assembly (GO:0051491)2.70092951
90neuromuscular process controlling balance (GO:0050885)2.67785362
91regulation of synaptic vesicle transport (GO:1902803)2.66517438
92sympathetic nervous system development (GO:0048485)2.66383342
93mitochondrion transport along microtubule (GO:0047497)2.66305169
94establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66305169
95developmental cell growth (GO:0048588)2.65302274
96neuron projection morphogenesis (GO:0048812)2.63542251
97spinal cord development (GO:0021510)2.63233300
98semaphorin-plexin signaling pathway (GO:0071526)2.63232923
99synaptic vesicle endocytosis (GO:0048488)2.62340583
100homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.61412797
101ephrin receptor signaling pathway (GO:0048013)2.60843238
102ganglion development (GO:0061548)2.60795514
103negative regulation of dendrite development (GO:2000171)2.60471013
104positive regulation of dendritic spine development (GO:0060999)2.59946726
105axonogenesis (GO:0007409)2.59420063
106regulation of development, heterochronic (GO:0040034)2.59167026
107intraciliary transport (GO:0042073)2.58719081
108protein localization to cilium (GO:0061512)2.57574830
109synapse organization (GO:0050808)2.57032630
110neuron-neuron synaptic transmission (GO:0007270)2.55496324
111nucleus localization (GO:0051647)2.53663407
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.53039706
113regulation of neuron migration (GO:2001222)2.51947871
114positive regulation of dendrite morphogenesis (GO:0050775)2.51856245
115neuron projection extension involved in neuron projection guidance (GO:1902284)2.51573656
116axon extension involved in axon guidance (GO:0048846)2.51573656
117activation of protein kinase A activity (GO:0034199)2.51057734
118regulation of respiratory system process (GO:0044065)2.50940060
119transmission of nerve impulse (GO:0019226)2.50701866
120epithelial cell differentiation involved in kidney development (GO:0035850)2.50500761
121cochlea development (GO:0090102)2.49401708
122negative regulation of oligodendrocyte differentiation (GO:0048715)2.49382516
123forebrain neuron differentiation (GO:0021879)2.47741760
124DNA damage response, detection of DNA damage (GO:0042769)2.46445519
125behavioral response to nicotine (GO:0035095)2.44330594
126cerebral cortex cell migration (GO:0021795)2.42996792
127glycosphingolipid biosynthetic process (GO:0006688)2.35620871
128DNA double-strand break processing (GO:0000729)2.35105420
129negative regulation of synaptic transmission, GABAergic (GO:0032229)2.34087032
130head development (GO:0060322)2.33118961
131cytoskeleton-dependent intracellular transport (GO:0030705)2.32649332
132kidney morphogenesis (GO:0060993)2.32610693
133negative regulation of DNA recombination (GO:0045910)2.32020311
134heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.31826722
135negative regulation of translation, ncRNA-mediated (GO:0040033)2.31320215
136regulation of translation, ncRNA-mediated (GO:0045974)2.31320215
137negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.31320215
138G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30476461
139organelle transport along microtubule (GO:0072384)2.27655786
140regulation of collateral sprouting (GO:0048670)2.27546241
141positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.27493125
142paraxial mesoderm development (GO:0048339)2.27380565
143somite development (GO:0061053)2.26423023
144apical protein localization (GO:0045176)2.25474036
145neuronal action potential propagation (GO:0019227)2.23205833
146short-term memory (GO:0007614)2.23179602
147regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.22241450
148startle response (GO:0001964)2.20453244
149microtubule-based transport (GO:0010970)2.18941380
150neuronal ion channel clustering (GO:0045161)2.16908197
151regulation of feeding behavior (GO:0060259)2.16495373
152ribonucleoprotein complex disassembly (GO:0032988)2.15383171
153establishment of melanosome localization (GO:0032401)2.15226030

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47045348
2GBX2_23144817_ChIP-Seq_PC3_Human3.16216463
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75915630
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.69909221
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66933925
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.61537695
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47049303
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33392956
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33392956
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32692301
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.28608690
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.27231970
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26547367
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22294166
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20811559
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15441220
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.11593131
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09861223
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08406822
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07553386
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06909613
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.98953868
23* REST_21632747_ChIP-Seq_MESCs_Mouse1.97925926
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.97486382
25EWS_26573619_Chip-Seq_HEK293_Human1.94484907
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94401342
27DROSHA_22980978_ChIP-Seq_HELA_Human1.89345180
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88674750
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85305535
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83682361
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.80116715
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.76319813
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75313486
34IGF1R_20145208_ChIP-Seq_DFB_Human1.73673433
35ZNF274_21170338_ChIP-Seq_K562_Hela1.73664987
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73388917
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.72257829
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71852826
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71452269
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66089733
41RNF2_27304074_Chip-Seq_NSC_Mouse1.63131810
42VDR_22108803_ChIP-Seq_LS180_Human1.59988865
43AR_21572438_ChIP-Seq_LNCaP_Human1.58765268
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.58451155
45* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57123240
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56029756
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53810088
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49103147
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49025254
50AHR_22903824_ChIP-Seq_MCF-7_Human1.42535703
51RING1B_27294783_Chip-Seq_ESCs_Mouse1.41505098
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41485722
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41244903
54* REST_18959480_ChIP-ChIP_MESCs_Mouse1.41208859
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41101080
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40270295
57* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39223790
58SMAD4_21799915_ChIP-Seq_A2780_Human1.39046830
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.38376562
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.37376766
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36836555
62TAF15_26573619_Chip-Seq_HEK293_Human1.35887926
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35810119
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.35564166
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.35454143
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33445188
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33445188
68P300_19829295_ChIP-Seq_ESCs_Human1.33305055
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.33187382
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32975761
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32513189
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31928528
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.31794659
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30649761
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30264233
76* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29367919
77FUS_26573619_Chip-Seq_HEK293_Human1.28880643
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26405052
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25972810
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.24211609
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24058490
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.22959637
83* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22862353
84AR_19668381_ChIP-Seq_PC3_Human1.22277077
85* CBP_20019798_ChIP-Seq_JUKART_Human1.21645598
86* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21645598
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21340108
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21189344
89* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19816637
90* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18915129
91IRF1_19129219_ChIP-ChIP_H3396_Human1.17731770
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17301340
93AR_25329375_ChIP-Seq_VCAP_Human1.16335600
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16304024
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15803321
96TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15778446
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.14956395
98ER_23166858_ChIP-Seq_MCF-7_Human1.14214842
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.14083231
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13879243
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12755050
102* NANOG_18555785_Chip-Seq_ESCs_Mouse1.11950298
103* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11927743
104STAT3_23295773_ChIP-Seq_U87_Human1.11680601
105SOX9_26525672_Chip-Seq_HEART_Mouse1.11328513
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11168443
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10249714
108* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09901317
109* KDM2B_26808549_Chip-Seq_K562_Human1.09555073
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09080595
111PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08542776
112ISL1_27105846_Chip-Seq_CPCs_Mouse1.08122921
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07902729
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07623084
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07485016
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06872863
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06533339
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06069251
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.05074871
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04179694
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04131464
122* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02393885
123* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01730756
124* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01346548
125STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01205265
126* RUNX2_22187159_ChIP-Seq_PCA_Human1.01095612
127JUN_21703547_ChIP-Seq_K562_Human1.00967141
128* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00195456
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99171474
130TP53_18474530_ChIP-ChIP_U2OS_Human0.98540492
131TCF4_23295773_ChIP-Seq_U87_Human0.98364055
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.97548681
133* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97340946
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97133861
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96706598
136* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96605039
137* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96549860
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95995112
139BCAT_22108803_ChIP-Seq_LS180_Human0.95596142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.79668588
2MP0000569_abnormal_digit_pigmentation4.56525286
3MP0000778_abnormal_nervous_system3.39328523
4MP0003880_abnormal_central_pattern3.23789630
5MP0004270_analgesia3.06476266
6MP0005423_abnormal_somatic_nervous3.03850365
7MP0003635_abnormal_synaptic_transmissio2.90682304
8MP0002063_abnormal_learning/memory/cond2.75168867
9MP0003787_abnormal_imprinting2.60577237
10MP0000537_abnormal_urethra_morphology2.53656926
11MP0005187_abnormal_penis_morphology2.07429634
12MP0002734_abnormal_mechanical_nocicepti2.07010130
13MP0002184_abnormal_innervation2.05765714
14MP0009745_abnormal_behavioral_response1.93754921
15MP0002572_abnormal_emotion/affect_behav1.88496770
16MP0004811_abnormal_neuron_physiology1.85836057
17MP0009780_abnormal_chondrocyte_physiolo1.85588794
18MP0002557_abnormal_social/conspecific_i1.77321894
19MP0003121_genomic_imprinting1.75641142
20MP0008877_abnormal_DNA_methylation1.73537464
21MP0001486_abnormal_startle_reflex1.72686200
22MP0003890_abnormal_embryonic-extraembry1.71654869
23MP0006276_abnormal_autonomic_nervous1.67920720
24MP0003122_maternal_imprinting1.66528462
25MP0001968_abnormal_touch/_nociception1.64077811
26MP0005248_abnormal_Harderian_gland1.63825382
27MP0002733_abnormal_thermal_nociception1.59645572
28MP0004858_abnormal_nervous_system1.57487607
29MP0003861_abnormal_nervous_system1.57027154
30MP0003119_abnormal_digestive_system1.51712599
31MP0000955_abnormal_spinal_cord1.50871598
32MP0003385_abnormal_body_wall1.49847587
33MP0002064_seizures1.46715091
34MP0000631_abnormal_neuroendocrine_gland1.46689232
35MP0008789_abnormal_olfactory_epithelium1.44872719
36MP0002152_abnormal_brain_morphology1.44704547
37MP0000516_abnormal_urinary_system1.39996981
38MP0005367_renal/urinary_system_phenotyp1.39996981
39MP0004885_abnormal_endolymph1.39408893
40MP0005386_behavior/neurological_phenoty1.38974050
41MP0004924_abnormal_behavior1.38974050
42MP0005499_abnormal_olfactory_system1.38863753
43MP0005394_taste/olfaction_phenotype1.38863753
44MP0002735_abnormal_chemical_nociception1.37921275
45MP0001440_abnormal_grooming_behavior1.37090877
46MP0003567_abnormal_fetal_cardiomyocyte1.36983048
47MP0009046_muscle_twitch1.33939193
48MP0001348_abnormal_lacrimal_gland1.32784093
49MP0009053_abnormal_anal_canal1.32674224
50MP0002102_abnormal_ear_morphology1.32332616
51MP0001188_hyperpigmentation1.31698240
52MP0002882_abnormal_neuron_morphology1.30318544
53MP0001293_anophthalmia1.28169269
54MP0002638_abnormal_pupillary_reflex1.27612987
55MP0006072_abnormal_retinal_apoptosis1.24923084
56MP0005645_abnormal_hypothalamus_physiol1.19907918
57MP0001970_abnormal_pain_threshold1.19444954
58MP0002697_abnormal_eye_size1.19093148
59MP0000534_abnormal_ureter_morphology1.18328125
60MP0002752_abnormal_somatic_nervous1.14960924
61MP0010234_abnormal_vibrissa_follicle1.14515098
62MP0003942_abnormal_urinary_system1.14481945
63MP0005253_abnormal_eye_physiology1.12090381
64MP0002067_abnormal_sensory_capabilities1.11786715
65MP0010030_abnormal_orbit_morphology1.11415564
66MP0000647_abnormal_sebaceous_gland1.08833686
67MP0001286_abnormal_eye_development1.08004738
68MP0003755_abnormal_palate_morphology1.07740200
69MP0003938_abnormal_ear_development1.07149386
70MP0005076_abnormal_cell_differentiation1.06226143
71MP0001984_abnormal_olfaction1.05735552
72MP0001299_abnormal_eye_distance/1.03352410
73MP0002081_perinatal_lethality1.01244802
74MP0003315_abnormal_perineum_morphology1.00384609
75MP0002909_abnormal_adrenal_gland0.99289917
76MP0002233_abnormal_nose_morphology0.98633707
77MP0002234_abnormal_pharynx_morphology0.97947310
78MP0001849_ear_inflammation0.97792790
79MP0005551_abnormal_eye_electrophysiolog0.97196757
80MP0003283_abnormal_digestive_organ0.95879878
81MP0002116_abnormal_craniofacial_bone0.95069256
82MP0003221_abnormal_cardiomyocyte_apopto0.94924584
83MP0006292_abnormal_olfactory_placode0.94398891
84MP0002066_abnormal_motor_capabilities/c0.92630704
85MP0003935_abnormal_craniofacial_develop0.91519895
86MP0003937_abnormal_limbs/digits/tail_de0.90235048
87MP0002938_white_spotting0.89966339
88MP0001529_abnormal_vocalization0.89576148
89MP0002736_abnormal_nociception_after0.89486292
90MP0002653_abnormal_ependyma_morphology0.88940533
91MP0003115_abnormal_respiratory_system0.88734812
92MP0000049_abnormal_middle_ear0.88472059
93MP0005391_vision/eye_phenotype0.87757188
94MP0004142_abnormal_muscle_tone0.87564621
95MP0002751_abnormal_autonomic_nervous0.86001319
96MP0001485_abnormal_pinna_reflex0.85679873
97MP0009703_decreased_birth_body0.85126564
98MP0001177_atelectasis0.84691512
99MP0003879_abnormal_hair_cell0.83651893
100MP0005623_abnormal_meninges_morphology0.82587431
101MP0005195_abnormal_posterior_eye0.81825755
102MP0002177_abnormal_outer_ear0.80965948
103MP0008995_early_reproductive_senescence0.79479224
104MP0008961_abnormal_basal_metabolism0.77340256
105MP0002084_abnormal_developmental_patter0.77093111
106MP0000566_synostosis0.77051976
107MP0003718_maternal_effect0.76753005
108MP0001346_abnormal_lacrimal_gland0.75663609
109MP0002272_abnormal_nervous_system0.75588113
110MP0000579_abnormal_nail_morphology0.75139440
111MP0003123_paternal_imprinting0.74968673
112MP0001501_abnormal_sleep_pattern0.74648422
113MP0005646_abnormal_pituitary_gland0.73353181
114MP0003136_yellow_coat_color0.73036114
115MP0003137_abnormal_impulse_conducting0.72840380
116MP0002069_abnormal_eating/drinking_beha0.70369503
117MP0001502_abnormal_circadian_rhythm0.69743234
118MP0004133_heterotaxia0.69658843
119MP0004742_abnormal_vestibular_system0.69491171
120MP0000026_abnormal_inner_ear0.69234310
121MP0002822_catalepsy0.69219348
122MP0004197_abnormal_fetal_growth/weight/0.68327042
123MP0003941_abnormal_skin_development0.65720165

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)3.30686887
2Drooling (HP:0002307)3.15499635
3Excessive salivation (HP:0003781)3.15499635
4Mutism (HP:0002300)3.10355904
5Inappropriate behavior (HP:0000719)3.10094138
6Myokymia (HP:0002411)3.04009273
7Short 4th metacarpal (HP:0010044)3.02923398
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02923398
9Gait imbalance (HP:0002141)3.00129196
10Broad-based gait (HP:0002136)2.95319365
11Hepatoblastoma (HP:0002884)2.95288302
12Amyotrophic lateral sclerosis (HP:0007354)2.92780138
13Limb dystonia (HP:0002451)2.76283415
14Focal seizures (HP:0007359)2.75723950
15Congenital primary aphakia (HP:0007707)2.74078130
16Genital tract atresia (HP:0001827)2.73464016
17Medial flaring of the eyebrow (HP:0010747)2.72666331
18Vaginal atresia (HP:0000148)2.71602004
19Focal motor seizures (HP:0011153)2.68829994
20Nephrogenic diabetes insipidus (HP:0009806)2.65343696
21Epileptic encephalopathy (HP:0200134)2.64723542
22Papillary thyroid carcinoma (HP:0002895)2.63686873
23Papilledema (HP:0001085)2.58074279
24Genetic anticipation (HP:0003743)2.54746019
25Elfin facies (HP:0004428)2.54214453
26Hyperacusis (HP:0010780)2.49188738
27Pachygyria (HP:0001302)2.43592191
28Abnormality of the labia minora (HP:0012880)2.41351287
29Poor eye contact (HP:0000817)2.41134793
30Protruding tongue (HP:0010808)2.35955296
31Disinhibition (HP:0000734)2.35740944
32Renal duplication (HP:0000075)2.35528845
33Progressive cerebellar ataxia (HP:0002073)2.34299648
34Sacral dimple (HP:0000960)2.33010714
35Pointed chin (HP:0000307)2.30019859
36Polyphagia (HP:0002591)2.29403888
37Specific learning disability (HP:0001328)2.26559162
38Lissencephaly (HP:0001339)2.25701046
39Abnormality of the 4th metacarpal (HP:0010012)2.24112085
40Subacute progressive viral hepatitis (HP:0006572)2.23214694
41Optic nerve hypoplasia (HP:0000609)2.20254943
42Abnormality of the corticospinal tract (HP:0002492)2.19631838
43Intestinal atresia (HP:0011100)2.19511765
44Ankle clonus (HP:0011448)2.19372983
45True hermaphroditism (HP:0010459)2.18590092
46Urinary bladder sphincter dysfunction (HP:0002839)2.18540485
47Termporal pattern (HP:0011008)2.17902083
48Insidious onset (HP:0003587)2.17902083
49Supranuclear gaze palsy (HP:0000605)2.17171581
50Apathy (HP:0000741)2.16287917
51Exotropia (HP:0000577)2.16139519
52Nephronophthisis (HP:0000090)2.15859412
53Macroorchidism (HP:0000053)2.15704887
54Colon cancer (HP:0003003)2.14410348
55Obsessive-compulsive behavior (HP:0000722)2.12968153
56Labial hypoplasia (HP:0000066)2.12686720
57Obstructive sleep apnea (HP:0002870)2.12545266
58Stereotypic behavior (HP:0000733)2.12278950
59Astrocytoma (HP:0009592)2.11703969
60Abnormality of the astrocytes (HP:0100707)2.11703969
61Shoulder girdle muscle weakness (HP:0003547)2.11383497
62Impaired social interactions (HP:0000735)2.10982730
63Abnormal social behavior (HP:0012433)2.10982730
64Abnormality of salivation (HP:0100755)2.10113082
65Failure to thrive in infancy (HP:0001531)2.08985646
66Urinary urgency (HP:0000012)2.08761473
67Renal hypoplasia (HP:0000089)2.08625603
68Poor coordination (HP:0002370)2.08305441
69Agitation (HP:0000713)2.07691742
70Hyperventilation (HP:0002883)2.07348650
71Hypoplasia of the brainstem (HP:0002365)2.06496302
72Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06496302
73Retinal dysplasia (HP:0007973)2.06444565
74Cutaneous finger syndactyly (HP:0010554)2.05378872
75Overriding aorta (HP:0002623)2.04773745
76Renovascular hypertension (HP:0100817)2.04481227
77Neoplasm of the adrenal cortex (HP:0100641)2.04461460
78Heterotopia (HP:0002282)2.04230033
79Pancreatic cysts (HP:0001737)2.02255673
80Transitional cell carcinoma of the bladder (HP:0006740)2.01999678
81Aqueductal stenosis (HP:0002410)2.01992173
82Megalencephaly (HP:0001355)2.00375765
83Morphological abnormality of the middle ear (HP:0008609)1.99952963
84Ankyloglossia (HP:0010296)1.99549543
85Micropenis (HP:0000054)1.99367179
86Pancreatic fibrosis (HP:0100732)1.97620289
87Progressive inability to walk (HP:0002505)1.96932803
88Diminished motivation (HP:0000745)1.96593621
89Broad foot (HP:0001769)1.95923046
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.95369126
91Abnormality of the musculature of the pelvis (HP:0001469)1.94898783
92Abnormality of the hip-girdle musculature (HP:0001445)1.94898783
93Scrotal hypoplasia (HP:0000046)1.94520592
94Leiomyosarcoma (HP:0100243)1.93727938
95Uterine leiomyosarcoma (HP:0002891)1.93727938
96Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92913540
97Impaired vibration sensation in the lower limbs (HP:0002166)1.92587221
98Midline defect of the nose (HP:0004122)1.91907850
99Septo-optic dysplasia (HP:0100842)1.91695999
100Hypoplastic female external genitalia (HP:0012815)1.91680035
101Akinesia (HP:0002304)1.91303708
102Bladder carcinoma (HP:0002862)1.91274847
103Bladder neoplasm (HP:0009725)1.91274847
104Germ cell neoplasia (HP:0100728)1.91123919
105Postaxial hand polydactyly (HP:0001162)1.90414583
106Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90281868
107Spastic tetraplegia (HP:0002510)1.89929983
108Hyperglycinemia (HP:0002154)1.86712379
109Shallow orbits (HP:0000586)1.86535553
110Absent eyebrow (HP:0002223)1.86276056
111Insomnia (HP:0100785)1.85153729
112Amblyopia (HP:0000646)1.84594653
113Hemiparesis (HP:0001269)1.84278765
114Visual hallucinations (HP:0002367)1.82701924
115Febrile seizures (HP:0002373)1.82405968
116Medulloblastoma (HP:0002885)1.81885745
117Bifid tongue (HP:0010297)1.81623882
118Abnormality of the lower motor neuron (HP:0002366)1.81544254
119Absent speech (HP:0001344)1.79983755
120Abnormality of the renal medulla (HP:0100957)1.79683997
121Narrow forehead (HP:0000341)1.79080647
122Intellectual disability, moderate (HP:0002342)1.78807649
123Sporadic (HP:0003745)1.78481570
124Anophthalmia (HP:0000528)1.78338267
125Split foot (HP:0001839)1.77960982
126Abnormal hair whorl (HP:0010721)1.77432928
127Lymphangioma (HP:0100764)1.77213549
128High anterior hairline (HP:0009890)1.77208446
129Trigonocephaly (HP:0000243)1.77168580
130Decreased testicular size (HP:0008734)1.75611955
131Hypsarrhythmia (HP:0002521)1.74960816
132Asymmetry of the thorax (HP:0001555)1.74412169
133Tented upper lip vermilion (HP:0010804)1.73707608
134Volvulus (HP:0002580)1.73618062
135Shawl scrotum (HP:0000049)1.73230682
136EEG with generalized epileptiform discharges (HP:0011198)1.72762993
137Polymicrogyria (HP:0002126)1.72732545
138Occipital encephalocele (HP:0002085)1.72063101
139Ulnar claw (HP:0001178)1.72020070
140Abnormality of the diencephalon (HP:0010662)1.71829452
141Oligodactyly (hands) (HP:0001180)1.71141743
142Abnormality of midbrain morphology (HP:0002418)1.70804252
143Molar tooth sign on MRI (HP:0002419)1.70804252
144Intellectual disability, profound (HP:0002187)1.70770950
145Epileptiform EEG discharges (HP:0011182)1.70109249
146Hypoplasia of the corpus callosum (HP:0002079)1.69054732
147Cutaneous syndactyly (HP:0012725)1.68678271
148Poor suck (HP:0002033)1.68614542
149Chronic hepatic failure (HP:0100626)1.68570849
150Heterochromia iridis (HP:0001100)1.68469577
151Inability to walk (HP:0002540)1.67630444
152Degeneration of the lateral corticospinal tracts (HP:0002314)1.67579733
153Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67579733
154Ependymoma (HP:0002888)1.67392300
155Short foot (HP:0001773)1.65379338
156Tubulointerstitial nephritis (HP:0001970)1.64960586
157Myelomeningocele (HP:0002475)1.64609881
158Thyroid carcinoma (HP:0002890)1.64306895
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.64293377
160Cupped ear (HP:0000378)1.63373013
161Bicornuate uterus (HP:0000813)1.61810735
162Severe Myopia (HP:0011003)1.60828062
163Thyroid-stimulating hormone excess (HP:0002925)1.60000586
164Spastic gait (HP:0002064)1.59818060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK17.61718992
2MAP3K93.17108401
3ERBB32.99876800
4TRIM282.82436395
5MAP3K42.75185558
6DYRK22.52139466
7KSR12.46692909
8NTRK22.33185815
9MAP2K72.31519136
10EPHA42.31188670
11SIK22.28459616
12MAPK132.22410625
13EPHB22.20654480
14MINK12.15919028
15NTRK32.11049347
16MAP4K22.08571800
17DAPK21.99175852
18SIK31.95931135
19LATS21.89390832
20SRPK11.85876875
21EPHA31.75515451
22BCR1.70806384
23CASK1.56674653
24DYRK31.46750470
25PAK61.43941758
26TYRO31.40972422
27FGFR21.35112603
28LATS11.34167852
29MAP2K41.33152867
30STK38L1.32351076
31MAP3K61.32278239
32PHKG11.23617658
33PHKG21.23617658
34CSNK1G21.22070904
35PINK11.21316913
36RPS6KA41.18663054
37MAP3K121.18351496
38PLK21.13789692
39CDK51.13020738
40TSSK61.10056540
41DAPK10.99228317
42UHMK10.95536903
43CAMKK10.92846699
44TAOK10.91437940
45WNK30.90929960
46RET0.90552857
47CSNK1A1L0.89992321
48TNIK0.89214307
49ICK0.88564648
50CAMK1G0.83962165
51PDGFRA0.83483130
52DYRK1A0.77341988
53MARK20.76728921
54OXSR10.76170823
55PRKCZ0.76003082
56KSR20.75958009
57CSNK1G30.73635967
58RIPK10.73621305
59CDK180.73311264
60PLK30.73296609
61ERBB20.70392857
62CCNB10.68967495
63STK390.68103370
64PRKD30.66853427
65RPS6KA20.66414069
66ACVR1B0.65854694
67STK110.65375062
68SGK20.63901643
69INSRR0.62575316
70CDK140.62295892
71CDK150.62162571
72PAK30.61227531
73FER0.59983614
74CAMK2A0.57599053
75CSNK1E0.55860390
76LIMK10.55329980
77YES10.54814338
78PLK40.53887842
79PRKCG0.53369844
80GRK10.52916162
81SGK10.52239586
82CSNK1G10.52216925
83SGK2230.51217547
84SGK4940.51217547
85CDK11A0.51067980
86DDR20.50334221
87CAMK2B0.50004736
88AKT30.49087408
89ZAK0.49047917
90FRK0.48374801
91MAPK90.48239291
92SGK30.47194049
93CDC70.46732745
94BMPR1B0.46419364
95MAP3K20.46384707
96ALK0.46344774
97PKN10.46200545
98FGFR10.45956133
99MKNK10.45728300
100CDK120.45149276
101PNCK0.45025435
102PLK10.44799376
103LMTK20.43668155
104NUAK10.43550467
105DMPK0.43067814
106CDK30.41854225
107WNK40.41548537
108CAMK1D0.41469927
109PRKACB0.41166518
110CSNK1D0.40677988
111MAPK80.39365823
112PRKAA10.39200546
113CSNK1A10.38945733
114FYN0.38802026
115ATM0.38634479
116PRKCE0.38439230
117ADRBK20.38080815
118BRD40.37652718
119DYRK1B0.37538569
120ROCK10.36850721
121ERBB40.35296295
122PDGFRB0.35229320
123TIE10.34745438
124CAMK40.34392155
125PKN20.33665744
126PRKDC0.33508410
127TTK0.33350261
128TGFBR10.33101892
129VRK10.32894948
130GSK3B0.32288584
131NTRK10.32178860
132FGFR30.32122149
133MAPK100.31965823
134PRPF4B0.31788275
135MKNK20.30124217
136FLT30.29981895
137RPS6KA30.29621288
138CDC42BPA0.29491973
139CDK190.28924116

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.44959529
2Axon guidance_Homo sapiens_hsa043602.32055557
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25383967
4Steroid biosynthesis_Homo sapiens_hsa001002.24154615
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10519223
6Protein export_Homo sapiens_hsa030601.96299176
7Synaptic vesicle cycle_Homo sapiens_hsa047211.91971771
8Circadian entrainment_Homo sapiens_hsa047131.80799336
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79953440
10Olfactory transduction_Homo sapiens_hsa047401.78407547
11Dopaminergic synapse_Homo sapiens_hsa047281.76369155
12Endometrial cancer_Homo sapiens_hsa052131.74487692
13Glutamatergic synapse_Homo sapiens_hsa047241.72489773
14Morphine addiction_Homo sapiens_hsa050321.71083508
15GABAergic synapse_Homo sapiens_hsa047271.70194442
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68229290
17Phototransduction_Homo sapiens_hsa047441.65503947
18Colorectal cancer_Homo sapiens_hsa052101.61664231
19Cholinergic synapse_Homo sapiens_hsa047251.57601591
20Long-term potentiation_Homo sapiens_hsa047201.55327738
21Butanoate metabolism_Homo sapiens_hsa006501.54674984
22ErbB signaling pathway_Homo sapiens_hsa040121.52489704
23Propanoate metabolism_Homo sapiens_hsa006401.42128069
24Cocaine addiction_Homo sapiens_hsa050301.42003506
25Gap junction_Homo sapiens_hsa045401.41304342
26Basal transcription factors_Homo sapiens_hsa030221.39706166
27Glioma_Homo sapiens_hsa052141.37594782
28Basal cell carcinoma_Homo sapiens_hsa052171.37173168
29Amphetamine addiction_Homo sapiens_hsa050311.36180268
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35283609
31Hippo signaling pathway_Homo sapiens_hsa043901.34701258
32Type II diabetes mellitus_Homo sapiens_hsa049301.32832050
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31391206
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27365317
35GnRH signaling pathway_Homo sapiens_hsa049121.21916490
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21614238
37Oxytocin signaling pathway_Homo sapiens_hsa049211.19228388
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.18863364
39Serotonergic synapse_Homo sapiens_hsa047261.18861183
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18085301
41Melanogenesis_Homo sapiens_hsa049161.17352285
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16846076
43Renin secretion_Homo sapiens_hsa049241.14920121
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13840949
45Wnt signaling pathway_Homo sapiens_hsa043101.13040437
46Taste transduction_Homo sapiens_hsa047421.12558665
47Estrogen signaling pathway_Homo sapiens_hsa049151.12492900
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11810693
49Renal cell carcinoma_Homo sapiens_hsa052111.11745513
50Long-term depression_Homo sapiens_hsa047301.11683253
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11462663
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10691723
53Non-homologous end-joining_Homo sapiens_hsa034501.09925100
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09110832
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08148966
56Hedgehog signaling pathway_Homo sapiens_hsa043401.08114958
57Salivary secretion_Homo sapiens_hsa049701.07525492
58Circadian rhythm_Homo sapiens_hsa047101.07398689
59Gastric acid secretion_Homo sapiens_hsa049711.06580467
60Viral myocarditis_Homo sapiens_hsa054161.06537510
61Oocyte meiosis_Homo sapiens_hsa041141.04139572
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03851821
63Adherens junction_Homo sapiens_hsa045201.03553006
64Dorso-ventral axis formation_Homo sapiens_hsa043201.02329886
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02195353
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01461816
67mTOR signaling pathway_Homo sapiens_hsa041501.00531142
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98710009
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97582371
70Insulin secretion_Homo sapiens_hsa049110.97529719
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96777813
72Fatty acid elongation_Homo sapiens_hsa000620.96454783
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95677651
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94183421
75Prolactin signaling pathway_Homo sapiens_hsa049170.93837133
76Chronic myeloid leukemia_Homo sapiens_hsa052200.93753763
77VEGF signaling pathway_Homo sapiens_hsa043700.93607102
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93231050
79Selenocompound metabolism_Homo sapiens_hsa004500.92436917
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91446746
81cAMP signaling pathway_Homo sapiens_hsa040240.90125257
82MicroRNAs in cancer_Homo sapiens_hsa052060.89779869
83Rap1 signaling pathway_Homo sapiens_hsa040150.88559894
84Pancreatic cancer_Homo sapiens_hsa052120.88526476
85RNA degradation_Homo sapiens_hsa030180.88338070
86Non-small cell lung cancer_Homo sapiens_hsa052230.88266807
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87981888
88MAPK signaling pathway_Homo sapiens_hsa040100.87173836
89Choline metabolism in cancer_Homo sapiens_hsa052310.83854391
90Ras signaling pathway_Homo sapiens_hsa040140.82632934
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81691520
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81670809
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81541316
94Fatty acid metabolism_Homo sapiens_hsa012120.81024441
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80645677
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80414057
97RNA transport_Homo sapiens_hsa030130.79341739
98beta-Alanine metabolism_Homo sapiens_hsa004100.78943330
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77602906
100Fanconi anemia pathway_Homo sapiens_hsa034600.76864032
101Notch signaling pathway_Homo sapiens_hsa043300.75729497
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75113759
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74995122
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74569583
105Calcium signaling pathway_Homo sapiens_hsa040200.73767762
106Tight junction_Homo sapiens_hsa045300.73407758
107Collecting duct acid secretion_Homo sapiens_hsa049660.72455981
108Proteoglycans in cancer_Homo sapiens_hsa052050.72010332
109Cardiac muscle contraction_Homo sapiens_hsa042600.71840383
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71668125
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70567679
112Melanoma_Homo sapiens_hsa052180.70482968
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70117996
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69990487
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.69934381
116Dilated cardiomyopathy_Homo sapiens_hsa054140.67759121
117mRNA surveillance pathway_Homo sapiens_hsa030150.67684279
118Ether lipid metabolism_Homo sapiens_hsa005650.67518815
119Vibrio cholerae infection_Homo sapiens_hsa051100.67005951
120Alcoholism_Homo sapiens_hsa050340.66271534
121Focal adhesion_Homo sapiens_hsa045100.66251836
122TNF signaling pathway_Homo sapiens_hsa046680.65766449
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64986088
124Insulin signaling pathway_Homo sapiens_hsa049100.64958017
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64490449
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64396472
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.64303905
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63833177
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63645918
130Chemokine signaling pathway_Homo sapiens_hsa040620.63345122
131Pathways in cancer_Homo sapiens_hsa052000.63136567
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63046704
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62572834
134Salmonella infection_Homo sapiens_hsa051320.62200964
135Parkinsons disease_Homo sapiens_hsa050120.61111455
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.60690523
137Oxidative phosphorylation_Homo sapiens_hsa001900.59795107
138Regulation of autophagy_Homo sapiens_hsa041400.58427866
139TGF-beta signaling pathway_Homo sapiens_hsa043500.57890103
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55940216
141Peroxisome_Homo sapiens_hsa041460.54220448
142AMPK signaling pathway_Homo sapiens_hsa041520.53919374
143Huntingtons disease_Homo sapiens_hsa050160.53755634
144Arginine and proline metabolism_Homo sapiens_hsa003300.52301667
145Spliceosome_Homo sapiens_hsa030400.50462332
146Pyruvate metabolism_Homo sapiens_hsa006200.49521236
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.47825362
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.47513616
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45710188
150Biosynthesis of amino acids_Homo sapiens_hsa012300.43362933
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42495302
152RNA polymerase_Homo sapiens_hsa030200.41593258
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41408811
154Retinol metabolism_Homo sapiens_hsa008300.39602082
155Fatty acid biosynthesis_Homo sapiens_hsa000610.38617942
156Cell cycle_Homo sapiens_hsa041100.36555804
157Linoleic acid metabolism_Homo sapiens_hsa005910.36537020
158Starch and sucrose metabolism_Homo sapiens_hsa005000.35418521

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