ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.23254096
2	L-fucose catabolic process (GO:0042355)	4.71755593
3	fucose catabolic process (GO:0019317)	4.71755593
4	L-fucose metabolic process (GO:0042354)	4.71755593
5	response to pheromone (GO:0019236)	4.68814869
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.81281998
7	cellular ketone body metabolic process (GO:0046950)	3.57870713
8	centriole replication (GO:0007099)	3.55228089
9	behavioral response to ethanol (GO:0048149)	3.53560671
10	DNA deamination (GO:0045006)	3.50038685
11	protein polyglutamylation (GO:0018095)	3.47960379
12	neural tube formation (GO:0001841)	3.45887580
13	cellular response to ATP (GO:0071318)	3.44946843
14	ubiquinone biosynthetic process (GO:0006744)	3.42693763
15	detection of light stimulus involved in visual perception (GO:0050908)	3.30834546
16	detection of light stimulus involved in sensory perception (GO:0050962)	3.30834546
17	pyrimidine nucleobase catabolic process (GO:0006208)	3.28863881
18	axoneme assembly (GO:0035082)	3.24677400
19	negative regulation of telomere maintenance (GO:0032205)	3.24256972
20	platelet dense granule organization (GO:0060155)	3.24145834
21	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.23804779
22	ketone body metabolic process (GO:1902224)	3.23295883
23	ubiquinone metabolic process (GO:0006743)	3.22027017
24	epithelial cilium movement (GO:0003351)	3.21567148
25	mannosylation (GO:0097502)	3.07064675
26	protein localization to cilium (GO:0061512)	3.06068855
27	neuronal action potential (GO:0019228)	3.04582536
28	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.04186183
29	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.96425178
30	gamma-aminobutyric acid transport (GO:0015812)	2.95612734
31	regulation of cilium movement (GO:0003352)	2.92619237
32	cilium or flagellum-dependent cell motility (GO:0001539)	2.92297502
33	cilium morphogenesis (GO:0060271)	2.88700988
34	nonmotile primary cilium assembly (GO:0035058)	2.87969573
35	rRNA catabolic process (GO:0016075)	2.86706505
36	indolalkylamine metabolic process (GO:0006586)	2.85315470
37	piRNA metabolic process (GO:0034587)	2.81803081
38	spinal cord motor neuron differentiation (GO:0021522)	2.81562185
39	nucleobase catabolic process (GO:0046113)	2.80166130
40	cornea development in camera-type eye (GO:0061303)	2.78729552
41	cilium organization (GO:0044782)	2.78609877
42	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78214803
43	regulation of neurotransmitter uptake (GO:0051580)	2.75057827
44	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.74700465
45	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.74700465
46	cilium assembly (GO:0042384)	2.71407449
47	reflex (GO:0060004)	2.69384613
48	regulation of telomere maintenance (GO:0032204)	2.68010694
49	tryptophan catabolic process (GO:0006569)	2.67735706
50	indole-containing compound catabolic process (GO:0042436)	2.67735706
51	indolalkylamine catabolic process (GO:0046218)	2.67735706
52	cilium movement (GO:0003341)	2.67365588
53	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.67135845
54	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.66455384
55	regulation of action potential (GO:0098900)	2.66123240
56	synaptic transmission, cholinergic (GO:0007271)	2.65908466
57	replication fork processing (GO:0031297)	2.65873452
58	quinone biosynthetic process (GO:1901663)	2.65137279
59	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.64937961
60	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.63863577
61	kynurenine metabolic process (GO:0070189)	2.62865094
62	fucosylation (GO:0036065)	2.62143430
63	recombinational repair (GO:0000725)	2.61727766
64	retinal cone cell development (GO:0046549)	2.60398967
65	somite development (GO:0061053)	2.60386266
66	kidney morphogenesis (GO:0060993)	2.59816271
67	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.59431744
68	male meiosis I (GO:0007141)	2.58220142
69	double-strand break repair via homologous recombination (GO:0000724)	2.57031337
70	peptidyl-histidine modification (GO:0018202)	2.56417421
71	neuron cell-cell adhesion (GO:0007158)	2.54088178
72	sulfation (GO:0051923)	2.53346769
73	serotonin metabolic process (GO:0042428)	2.51378110
74	tryptophan metabolic process (GO:0006568)	2.49354620
75	negative regulation of mast cell activation (GO:0033004)	2.49073228
76	water-soluble vitamin biosynthetic process (GO:0042364)	2.46321286
77	indole-containing compound metabolic process (GO:0042430)	2.46056125
78	protein-cofactor linkage (GO:0018065)	2.45856902
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.44705531
80	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.44705531
81	NADH dehydrogenase complex assembly (GO:0010257)	2.44705531
82	postsynaptic membrane organization (GO:0001941)	2.44129163
83	opioid receptor signaling pathway (GO:0038003)	2.41797876
84	intraciliary transport (GO:0042073)	2.41476307
85	somite rostral/caudal axis specification (GO:0032525)	2.41413185
86	primary amino compound metabolic process (GO:1901160)	2.40983030
87	embryonic epithelial tube formation (GO:0001838)	2.38930954
88	photoreceptor cell development (GO:0042461)	2.38096389
89	nephron epithelium morphogenesis (GO:0072088)	2.38087114
90	nephron tubule morphogenesis (GO:0072078)	2.38087114
91	serotonin receptor signaling pathway (GO:0007210)	2.37746916
92	photoreceptor cell maintenance (GO:0045494)	2.37707041
93	positive regulation of fatty acid transport (GO:2000193)	2.37468087
94	positive regulation of prostaglandin secretion (GO:0032308)	2.36928701
95	regulation of hexokinase activity (GO:1903299)	2.36899850
96	regulation of glucokinase activity (GO:0033131)	2.36899850
97	inositol phosphate catabolic process (GO:0071545)	2.36444595
98	startle response (GO:0001964)	2.35766293
99	regulation of hippo signaling (GO:0035330)	2.35677871
100	protein complex biogenesis (GO:0070271)	2.35248968

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.38942009
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.13434554
3	VDR_22108803_ChIP-Seq_LS180_Human	2.98682415
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.89823212
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.76140868
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.56086777
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.51964725
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.49261998
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.41261829
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34328611
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26667601
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22072355
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21483004
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.18111176
15	EWS_26573619_Chip-Seq_HEK293_Human	2.15525845
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15372607
17	FUS_26573619_Chip-Seq_HEK293_Human	2.09772650
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.06723724
19	P300_19829295_ChIP-Seq_ESCs_Human	1.98719224
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.96592554
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.95625524
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93927285
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73314626
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71160599
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.66793941
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.64032311
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60300867
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.56655435
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56210711
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55249390
31	STAT3_23295773_ChIP-Seq_U87_Human	1.53198597
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.53146476
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53139719
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.51159420
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49980317
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49680243
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.48718405
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47754890
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.47754890
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45876283
41	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44563424
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44419393
43	TCF4_23295773_ChIP-Seq_U87_Human	1.44181541
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43491438
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42646602
46	AR_25329375_ChIP-Seq_VCAP_Human	1.41400313
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41059951
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36417910
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34033274
50	AR_21572438_ChIP-Seq_LNCaP_Human	1.33330280
51	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.29208000
52	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28282656
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27609159
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27557718
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27041449
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26999381
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26759655
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25599390
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25368815
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25368815
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23376219
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23376219
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21717889
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21496689
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21434569
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21434569
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.21325847
68	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.21269480
69	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21170620
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20459819
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20443099
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20335350
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19994179
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17935860
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15163559
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15010170
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.14089322
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13161815
79	VDR_23849224_ChIP-Seq_CD4+_Human	1.12649327
80	NCOR_22424771_ChIP-Seq_293T_Human	1.12155306
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11885403
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11337160
83	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09856815
84	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09728862
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08412619
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05510983
87	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.04873964
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02567473
89	AR_20517297_ChIP-Seq_VCAP_Human	1.02405822
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01482420
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99915553
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99443115
93	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99230968
94	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99200344
95	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99137879
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.98494865
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96857716
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95679875
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95607521
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94922288

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.72784242
2	MP0000569_abnormal_digit_pigmentation	2.65792487
3	MP0002102_abnormal_ear_morphology	2.56235378
4	MP0003787_abnormal_imprinting	2.51218506
5	MP0009046_muscle_twitch	2.35949975
6	MP0006072_abnormal_retinal_apoptosis	2.32448260
7	MP0005551_abnormal_eye_electrophysiolog	2.31432712
8	MP0002837_dystrophic_cardiac_calcinosis	2.28266490
9	MP0003195_calcinosis	2.23454213
10	MP0001968_abnormal_touch/_nociception	2.19795206
11	MP0008872_abnormal_physiological_respon	2.13944157
12	MP0003880_abnormal_central_pattern	2.11847405
13	MP0009745_abnormal_behavioral_response	2.04968345
14	MP0004885_abnormal_endolymph	2.03670250
15	MP0006292_abnormal_olfactory_placode	1.99356381
16	MP0004133_heterotaxia	1.95138028
17	MP0005253_abnormal_eye_physiology	1.95010352
18	MP0002735_abnormal_chemical_nociception	1.86193407
19	MP0006276_abnormal_autonomic_nervous	1.81233119
20	MP0005645_abnormal_hypothalamus_physiol	1.81124560
21	MP0008058_abnormal_DNA_repair	1.80936147
22	MP0004043_abnormal_pH_regulation	1.79153253
23	MP0000631_abnormal_neuroendocrine_gland	1.74746047
24	MP0000427_abnormal_hair_cycle	1.74386252
25	MP0003283_abnormal_digestive_organ	1.74204139
26	MP0002638_abnormal_pupillary_reflex	1.71118054
27	MP0004142_abnormal_muscle_tone	1.70487016
28	MP0005646_abnormal_pituitary_gland	1.69713263
29	MP0001986_abnormal_taste_sensitivity	1.64863651
30	MP0002736_abnormal_nociception_after	1.62431035
31	MP0001529_abnormal_vocalization	1.57722857
32	MP0005174_abnormal_tail_pigmentation	1.57514638
33	MP0002272_abnormal_nervous_system	1.55581215
34	MP0002876_abnormal_thyroid_physiology	1.51865574
35	MP0001486_abnormal_startle_reflex	1.51003235
36	MP0002572_abnormal_emotion/affect_behav	1.49319635
37	MP0004147_increased_porphyrin_level	1.48472132
38	MP0003890_abnormal_embryonic-extraembry	1.47369044
39	MP0000372_irregular_coat_pigmentation	1.45280490
40	MP0001984_abnormal_olfaction	1.45100747
41	MP0008875_abnormal_xenobiotic_pharmacok	1.44922799
42	MP0004742_abnormal_vestibular_system	1.41007256
43	MP0002234_abnormal_pharynx_morphology	1.39762603
44	MP0001501_abnormal_sleep_pattern	1.39054654
45	MP0002557_abnormal_social/conspecific_i	1.39035082
46	MP0005084_abnormal_gallbladder_morpholo	1.38604471
47	MP0002064_seizures	1.36959075
48	MP0002751_abnormal_autonomic_nervous	1.29133996
49	MP0002733_abnormal_thermal_nociception	1.28468877
50	MP0003121_genomic_imprinting	1.27965525
51	MP0001485_abnormal_pinna_reflex	1.26634327
52	MP0004924_abnormal_behavior	1.26519166
53	MP0005386_behavior/neurological_phenoty	1.26519166
54	MP0002938_white_spotting	1.25742034
55	MP0004145_abnormal_muscle_electrophysio	1.24595968
56	MP0002653_abnormal_ependyma_morphology	1.24324218
57	MP0001970_abnormal_pain_threshold	1.22773728
58	MP0002067_abnormal_sensory_capabilities	1.20464968
59	MP0005083_abnormal_biliary_tract	1.20139844
60	MP0002063_abnormal_learning/memory/cond	1.19688081
61	MP0002928_abnormal_bile_duct	1.19557605
62	MP0005389_reproductive_system_phenotype	1.19285041
63	MP0002909_abnormal_adrenal_gland	1.17177822
64	MP0001919_abnormal_reproductive_system	1.14370356
65	MP0003646_muscle_fatigue	1.14062588
66	MP0001905_abnormal_dopamine_level	1.12584335
67	MP0003136_yellow_coat_color	1.11512963
68	MP0000778_abnormal_nervous_system	1.10658865
69	MP0003122_maternal_imprinting	1.10161168
70	MP0003635_abnormal_synaptic_transmissio	1.09590168
71	MP0005195_abnormal_posterior_eye	1.08732679
72	MP0002160_abnormal_reproductive_system	1.07222863
73	MP0002163_abnormal_gland_morphology	1.05626736
74	MP0002184_abnormal_innervation	1.03253697
75	MP0002095_abnormal_skin_pigmentation	1.02105265
76	MP0001440_abnormal_grooming_behavior	0.94994412
77	MP0001502_abnormal_circadian_rhythm	0.94281528
78	MP0005220_abnormal_exocrine_pancreas	0.93535774
79	MP0005379_endocrine/exocrine_gland_phen	0.93188206
80	MP0003698_abnormal_male_reproductive	0.91848935
81	MP0005423_abnormal_somatic_nervous	0.91456449
82	MP0010386_abnormal_urinary_bladder	0.90889524
83	MP0002229_neurodegeneration	0.90735039
84	MP0003718_maternal_effect	0.89659233
85	MP0002752_abnormal_somatic_nervous	0.88589092
86	MP0001944_abnormal_pancreas_morphology	0.88185343
87	MP0002693_abnormal_pancreas_physiology	0.87878104
88	MP0003011_delayed_dark_adaptation	0.87446120
89	MP0000383_abnormal_hair_follicle	0.84379143
90	MP0002734_abnormal_mechanical_nocicepti	0.81545187
91	MP0008995_early_reproductive_senescence	0.80424216
92	MP0008775_abnormal_heart_ventricle	0.80331872
93	MP0005332_abnormal_amino_acid	0.79054573
94	MP0003878_abnormal_ear_physiology	0.78051383
95	MP0005377_hearing/vestibular/ear_phenot	0.78051383
96	MP0008961_abnormal_basal_metabolism	0.77174095
97	MP0005391_vision/eye_phenotype	0.76303293
98	MP0001324_abnormal_eye_pigmentation	0.76296850
99	MP0001929_abnormal_gametogenesis	0.75973100
100	MP0001963_abnormal_hearing_physiology	0.75138163

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.47103890
2	Pancreatic fibrosis (HP:0100732)	4.11709245
3	True hermaphroditism (HP:0010459)	3.87050537
4	Abnormality of midbrain morphology (HP:0002418)	3.86852124
5	Molar tooth sign on MRI (HP:0002419)	3.86852124
6	Nephronophthisis (HP:0000090)	3.69799863
7	Abnormality of the renal cortex (HP:0011035)	3.59925533
8	Abnormality of the renal medulla (HP:0100957)	3.40640619
9	Medial flaring of the eyebrow (HP:0010747)	3.34063925
10	Congenital stationary night blindness (HP:0007642)	3.33431116
11	Hyperventilation (HP:0002883)	3.25557227
12	Type II lissencephaly (HP:0007260)	3.04396308
13	Renal cortical cysts (HP:0000803)	3.02987015
14	Attenuation of retinal blood vessels (HP:0007843)	2.94005505
15	Pendular nystagmus (HP:0012043)	2.86227177
16	Cystic liver disease (HP:0006706)	2.77079666
17	Chronic hepatic failure (HP:0100626)	2.73705082
18	Gait imbalance (HP:0002141)	2.71385058
19	Abolished electroretinogram (ERG) (HP:0000550)	2.69238187
20	Tubular atrophy (HP:0000092)	2.67948235
21	Congenital primary aphakia (HP:0007707)	2.60503897
22	Lissencephaly (HP:0001339)	2.53997120
23	Nephrogenic diabetes insipidus (HP:0009806)	2.53009974
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.48509476
25	Inability to walk (HP:0002540)	2.41826038
26	Polydipsia (HP:0001959)	2.40446789
27	Abnormal drinking behavior (HP:0030082)	2.40446789
28	Bony spicule pigmentary retinopathy (HP:0007737)	2.33630298
29	Abnormality of the pons (HP:0007361)	2.33287899
30	Progressive inability to walk (HP:0002505)	2.32912609
31	Broad-based gait (HP:0002136)	2.32112631
32	Hypoplasia of the pons (HP:0012110)	2.30414748
33	Sclerocornea (HP:0000647)	2.29613050
34	Gaze-evoked nystagmus (HP:0000640)	2.29558734
35	Progressive cerebellar ataxia (HP:0002073)	2.28403674
36	Hemiparesis (HP:0001269)	2.24922539
37	Absent/shortened dynein arms (HP:0200106)	2.23982510
38	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.23982510
39	Furrowed tongue (HP:0000221)	2.23768706
40	Congenital hepatic fibrosis (HP:0002612)	2.21469713
41	Focal motor seizures (HP:0011153)	2.16712412
42	Large for gestational age (HP:0001520)	2.16666521
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15039862
44	Genetic anticipation (HP:0003743)	2.14688938
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.14294912
46	Abnormality of alanine metabolism (HP:0010916)	2.14294912
47	Hyperalaninemia (HP:0003348)	2.14294912
48	Increased corneal curvature (HP:0100692)	2.12951577
49	Keratoconus (HP:0000563)	2.12951577
50	Stomatitis (HP:0010280)	2.11335511
51	Postaxial foot polydactyly (HP:0001830)	2.09243498
52	Genital tract atresia (HP:0001827)	2.07797526
53	Anencephaly (HP:0002323)	2.07118495
54	Polyuria (HP:0000103)	2.06237559
55	Oligodactyly (hands) (HP:0001180)	2.05595198
56	Pachygyria (HP:0001302)	2.04592024
57	Abnormal biliary tract physiology (HP:0012439)	2.03462725
58	Bile duct proliferation (HP:0001408)	2.03462725
59	Vaginal atresia (HP:0000148)	2.03157748
60	Widely spaced teeth (HP:0000687)	2.00355158
61	Hypothermia (HP:0002045)	2.00134316
62	Tubulointerstitial nephritis (HP:0001970)	1.99394622
63	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.98839969
64	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.97710326
65	Protruding tongue (HP:0010808)	1.96931629
66	Poor coordination (HP:0002370)	1.96755815
67	Limb dystonia (HP:0002451)	1.96420837
68	Concave nail (HP:0001598)	1.96237013
69	Tubulointerstitial abnormality (HP:0001969)	1.95476019
70	Febrile seizures (HP:0002373)	1.93935821
71	Absent speech (HP:0001344)	1.92757346
72	Mitochondrial inheritance (HP:0001427)	1.92746945
73	Cerebellar dysplasia (HP:0007033)	1.91916434
74	Increased CSF lactate (HP:0002490)	1.91506657
75	Acute necrotizing encephalopathy (HP:0006965)	1.88162669
76	Intestinal atresia (HP:0011100)	1.88127222
77	Male pseudohermaphroditism (HP:0000037)	1.87234492
78	Patellar aplasia (HP:0006443)	1.86990904
79	Severe muscular hypotonia (HP:0006829)	1.85246476
80	Colon cancer (HP:0003003)	1.83911370
81	Ketoacidosis (HP:0001993)	1.83594180
82	Progressive macrocephaly (HP:0004481)	1.83177576
83	Decreased central vision (HP:0007663)	1.82041547
84	Optic disc pallor (HP:0000543)	1.80246014
85	Aplasia/Hypoplasia of the patella (HP:0006498)	1.79254209
86	Fair hair (HP:0002286)	1.75993099
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.75872961
88	Abnormal respiratory motile cilium morphology (HP:0005938)	1.75872961
89	Postaxial hand polydactyly (HP:0001162)	1.74203196
90	Small hand (HP:0200055)	1.74021088
91	Occipital encephalocele (HP:0002085)	1.73502757
92	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72292136
93	Chorioretinal atrophy (HP:0000533)	1.71323478
94	Agitation (HP:0000713)	1.70367136
95	Astigmatism (HP:0000483)	1.69806465
96	Ketosis (HP:0001946)	1.68642319
97	Drooling (HP:0002307)	1.67656276
98	Lipid accumulation in hepatocytes (HP:0006561)	1.67540678
99	Aganglionic megacolon (HP:0002251)	1.66591484
100	Optic nerve hypoplasia (HP:0000609)	1.66037168

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.62665256
2	ADRBK2	3.76988485
3	MAP4K2	3.24322363
4	TAOK3	3.23964980
5	WNK3	2.89033319
6	BMPR1B	2.63692613
7	NUAK1	2.51724464
8	MAP3K4	2.43004615
9	WNK4	2.30660873
10	GRK1	2.21986626
11	PINK1	2.17861817
12	CASK	1.93070543
13	ZAK	1.81019171
14	MARK1	1.79156248
15	MAPK13	1.78720752
16	MAP2K7	1.75930370
17	TRIM28	1.69397795
18	INSRR	1.53427190
19	ACVR1B	1.42772198
20	STK39	1.42354683
21	PAK3	1.41376603
22	CSNK1G1	1.38108604
23	BCKDK	1.34203506
24	CSNK1G3	1.28097906
25	DYRK2	1.26890993
26	CAMKK2	1.24886567
27	CSNK1G2	1.22579687
28	OXSR1	1.22495204
29	ERBB3	1.21618812
30	MKNK2	1.21524962
31	PNCK	1.20154769
32	TLK1	1.16517742
33	TXK	1.05538849
34	BCR	1.03755763
35	MAP2K6	1.03660118
36	PRKCE	1.03631716
37	NEK2	1.03604223
38	SIK2	0.98428528
39	ADRBK1	0.96823282
40	VRK1	0.94414915
41	CSNK1A1L	0.89338340
42	TAF1	0.88029019
43	PLK4	0.87721468
44	DAPK2	0.86499884
45	TNIK	0.82995180
46	PRKCG	0.82227432
47	CCNB1	0.81897216
48	EIF2AK3	0.81113040
49	RPS6KA4	0.81095051
50	PLK2	0.80695322
51	STK38L	0.80135054
52	PIK3CA	0.78028006
53	NTRK3	0.76493200
54	MAP2K4	0.74561971
55	MAPKAPK5	0.73089474
56	FLT3	0.71499031
57	VRK2	0.70582473
58	PHKG2	0.69769566
59	PHKG1	0.69769566
60	TGFBR1	0.68758849
61	MKNK1	0.65722665
62	IKBKB	0.65356948
63	STK3	0.64864189
64	CDK3	0.63674149
65	RPS6KA5	0.62844640
66	NTRK2	0.61910708
67	PTK2B	0.61315141
68	PKN1	0.58342830
69	MAPK15	0.57999273
70	TEC	0.57916136
71	PRKCQ	0.57360738
72	PRKAA1	0.53307977
73	CAMK2A	0.53297716
74	TRPM7	0.52296355
75	CSNK1A1	0.51912568
76	CHUK	0.51754457
77	DYRK3	0.49092103
78	MUSK	0.48178219
79	MAPKAPK3	0.48028503
80	ATR	0.47862841
81	IRAK1	0.47779717
82	FGFR2	0.46404642
83	ITK	0.43841195
84	CAMK1	0.42855333
85	CHEK2	0.40825890
86	PRKACA	0.40141924
87	CSNK1D	0.39657303
88	AKT3	0.37357404
89	PLK3	0.36385250
90	ATM	0.36202445
91	CAMK2D	0.35819912
92	CDK8	0.34521784
93	TNK2	0.33566878
94	WNK1	0.33165212
95	PLK1	0.33085585
96	MINK1	0.32941708
97	PRKCI	0.32330228
98	PAK6	0.32111429
99	PRKAA2	0.29990523
100	PRKG1	0.28954127

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.43570075
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.89199854
3	Phototransduction_Homo sapiens_hsa04744	2.67867223
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.65644200
5	Butanoate metabolism_Homo sapiens_hsa00650	2.54607589
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39591081
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.30610920
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.28328329
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.25859861
10	Nicotine addiction_Homo sapiens_hsa05033	2.25683240
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22881517
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.22496543
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.18795820
14	Nitrogen metabolism_Homo sapiens_hsa00910	2.11522920
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.08323824
16	Protein export_Homo sapiens_hsa03060	2.04140917
17	Homologous recombination_Homo sapiens_hsa03440	1.92965633
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.92466866
19	Basal transcription factors_Homo sapiens_hsa03022	1.90773037
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.88753457
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.77161390
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.62742404
23	Taste transduction_Homo sapiens_hsa04742	1.59776377
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47676592
25	Caffeine metabolism_Homo sapiens_hsa00232	1.45506304
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.37585300
27	RNA degradation_Homo sapiens_hsa03018	1.36909988
28	Propanoate metabolism_Homo sapiens_hsa00640	1.31803795
29	Parkinsons disease_Homo sapiens_hsa05012	1.28558366
30	RNA polymerase_Homo sapiens_hsa03020	1.28462639
31	Olfactory transduction_Homo sapiens_hsa04740	1.26628187
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.21083970
33	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.20038940
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.13489973
35	One carbon pool by folate_Homo sapiens_hsa00670	1.12260699
36	Morphine addiction_Homo sapiens_hsa05032	1.11831556
37	Peroxisome_Homo sapiens_hsa04146	1.10301365
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05771308
39	Insulin secretion_Homo sapiens_hsa04911	1.04897237
40	Regulation of autophagy_Homo sapiens_hsa04140	1.04295626
41	Circadian entrainment_Homo sapiens_hsa04713	1.02901092
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.99247446
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.98755318
44	Serotonergic synapse_Homo sapiens_hsa04726	0.97625013
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.97254913
46	GABAergic synapse_Homo sapiens_hsa04727	0.96141376
47	Primary immunodeficiency_Homo sapiens_hsa05340	0.95034496
48	Huntingtons disease_Homo sapiens_hsa05016	0.91396354
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.86747418
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86492656
51	Circadian rhythm_Homo sapiens_hsa04710	0.85362259
52	Salivary secretion_Homo sapiens_hsa04970	0.82492467
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82177317
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76136554
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.74447339
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.74321235
57	ABC transporters_Homo sapiens_hsa02010	0.71632452
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71067552
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69165255
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69014026
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68892263
62	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.68807983
63	Long-term depression_Homo sapiens_hsa04730	0.67730190
64	Retinol metabolism_Homo sapiens_hsa00830	0.67354652
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65419334
66	Alzheimers disease_Homo sapiens_hsa05010	0.65024609
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64961769
68	Cocaine addiction_Homo sapiens_hsa05030	0.62866167
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61344926
70	Asthma_Homo sapiens_hsa05310	0.61181743
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60350192
72	Metabolic pathways_Homo sapiens_hsa01100	0.59723054
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.59302837
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.58863024
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58253329
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.57541450
77	Histidine metabolism_Homo sapiens_hsa00340	0.57492340
78	Purine metabolism_Homo sapiens_hsa00230	0.55846279
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.55579497
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.55330629
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52343064
82	Amphetamine addiction_Homo sapiens_hsa05031	0.52240773
83	Sulfur metabolism_Homo sapiens_hsa00920	0.51699989
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50042484
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48363072
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47538107
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46224906
88	Base excision repair_Homo sapiens_hsa03410	0.45719483
89	Lysine degradation_Homo sapiens_hsa00310	0.45156771
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44029656
91	Cholinergic synapse_Homo sapiens_hsa04725	0.40295879
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37285682
93	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36866514
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.36347816
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34961557
96	Proteasome_Homo sapiens_hsa03050	0.34655048
97	RNA transport_Homo sapiens_hsa03013	0.32472428
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.25825993
99	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.23998379
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.23679587

FNBP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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