FNBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.34462928
2mitotic sister chromatid cohesion (GO:0007064)4.20917634
3regulation of B cell receptor signaling pathway (GO:0050855)4.06059633
4nuclear pore organization (GO:0006999)4.04292948
5histone H3-K4 trimethylation (GO:0080182)3.91876273
6positive regulation of gamma-delta T cell activation (GO:0046645)3.91639177
7Peyers patch development (GO:0048541)3.65025672
8mucosal-associated lymphoid tissue development (GO:0048537)3.65025672
9T cell migration (GO:0072678)3.63084328
10response to interleukin-15 (GO:0070672)3.62231423
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.59318689
12histone H3-K4 methylation (GO:0051568)3.53121583
13positive regulation of mitotic sister chromatid separation (GO:1901970)3.47030717
14positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47030717
15positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47030717
16pore complex assembly (GO:0046931)3.42096174
17pre-miRNA processing (GO:0031054)3.41258686
18protein localization to kinetochore (GO:0034501)3.40152525
19regulation of B cell differentiation (GO:0045577)3.37864619
20negative regulation of histone methylation (GO:0031061)3.37299450
21negative regulation of erythrocyte differentiation (GO:0045647)3.37028863
22response to muramyl dipeptide (GO:0032495)3.32243132
23cellular response to interleukin-15 (GO:0071350)3.32134557
24histone H4-K16 acetylation (GO:0043984)3.31807887
25phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.29813831
26negative regulation of T cell mediated immunity (GO:0002710)3.29113568
27regulation of granulocyte differentiation (GO:0030852)3.26092915
28CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.25882944
29germinal center formation (GO:0002467)3.25711673
30peptidyl-lysine trimethylation (GO:0018023)3.24271585
31cellular response to ethanol (GO:0071361)3.21785538
32regulation of histone H3-K27 methylation (GO:0061085)3.19365780
33regulation of histone H3-K9 methylation (GO:0051570)3.18605531
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.16951779
35leukocyte aggregation (GO:0070486)3.16778780
36mitotic chromosome condensation (GO:0007076)3.16017419
37regulation of sister chromatid cohesion (GO:0007063)3.12454887
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10669436
39kinetochore organization (GO:0051383)3.09384103
40sister chromatid segregation (GO:0000819)3.08849851
41protein localization to chromosome, centromeric region (GO:0071459)3.08740866
42regulation of RNA export from nucleus (GO:0046831)3.05995192
43positive regulation of chromosome segregation (GO:0051984)3.05217726
44histone H3-K9 demethylation (GO:0033169)3.04584562
45T cell lineage commitment (GO:0002360)3.03227286
46DNA unwinding involved in DNA replication (GO:0006268)3.01930050
47regulation of nuclear cell cycle DNA replication (GO:0033262)2.99828425
48B cell homeostasis (GO:0001782)2.97965339
49regulation of gamma-delta T cell differentiation (GO:0045586)2.97037123
50dosage compensation (GO:0007549)2.95237813
51histone lysine demethylation (GO:0070076)2.95031877
52regulation of gamma-delta T cell activation (GO:0046643)2.92164068
53mitotic sister chromatid segregation (GO:0000070)2.91795329
54mitotic nuclear envelope disassembly (GO:0007077)2.91725406
55histone H3-K9 methylation (GO:0051567)2.91403934
56DNA duplex unwinding (GO:0032508)2.91332006
57histone mRNA catabolic process (GO:0071044)2.89840265
58DNA geometric change (GO:0032392)2.88953871
59T cell homeostasis (GO:0043029)2.88651889
60negative regulation of RNA splicing (GO:0033119)2.88143289
61regulation of T cell tolerance induction (GO:0002664)2.87293963
62histone H3 deacetylation (GO:0070932)2.86608068
63regulation of DNA endoreduplication (GO:0032875)2.86575465
64interkinetic nuclear migration (GO:0022027)2.85753368
65histone demethylation (GO:0016577)2.85058710
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84889828
67tolerance induction (GO:0002507)2.83911397
68DNA topological change (GO:0006265)2.83317971
69histone lysine methylation (GO:0034968)2.82679460
70regulation of alpha-beta T cell proliferation (GO:0046640)2.80570467
71meiotic chromosome segregation (GO:0045132)2.78005014
72positive thymic T cell selection (GO:0045059)2.76585593
73positive regulation of interleukin-2 production (GO:0032743)2.76435063
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75899866
75histone deubiquitination (GO:0016578)2.73022050
76regulation of nucleobase-containing compound transport (GO:0032239)2.72913894
77activated T cell proliferation (GO:0050798)2.72782414
78regulation of histone methylation (GO:0031060)2.72169355
79negative regulation of mRNA processing (GO:0050686)2.71953663
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.68988424
81histone H3-K36 demethylation (GO:0070544)2.68925537
82membrane disassembly (GO:0030397)2.68883105
83nuclear envelope disassembly (GO:0051081)2.68883105
84alpha-beta T cell differentiation (GO:0046632)2.68420431
85positive regulation of protein deacetylation (GO:0090312)2.67486357
86negative regulation of lymphocyte mediated immunity (GO:0002707)2.66729016
87histone H3-K9 modification (GO:0061647)2.65681614
88cytoplasmic mRNA processing body assembly (GO:0033962)2.65510309
89antigen receptor-mediated signaling pathway (GO:0050851)2.64656398
90poly(A)+ mRNA export from nucleus (GO:0016973)2.64280882
91B cell proliferation (GO:0042100)2.64234903
92replication fork processing (GO:0031297)2.63835823
93negative T cell selection (GO:0043383)2.63360620
94regulation of tolerance induction (GO:0002643)2.62441735
95positive regulation of DNA-templated transcription, initiation (GO:2000144)2.62118803
96defense response to protozoan (GO:0042832)2.61651216
97negative thymic T cell selection (GO:0045060)2.60971664
98mitotic metaphase plate congression (GO:0007080)2.60333129
99positive regulation of histone deacetylation (GO:0031065)2.60041700
100regulation of interleukin-12 biosynthetic process (GO:0045075)2.59455057
101peptidyl-lysine methylation (GO:0018022)2.59253755
102negative regulation of bone resorption (GO:0045779)2.59036181
103NIK/NF-kappaB signaling (GO:0038061)2.58627971
104cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.58266650
105B cell receptor signaling pathway (GO:0050853)2.58205810
106kinetochore assembly (GO:0051382)2.57891872
107regulation of histone H3-K4 methylation (GO:0051569)2.57577859
108positive regulation of gene expression, epigenetic (GO:0045815)2.57170081
109regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.56727819
110positive regulation of developmental pigmentation (GO:0048087)2.54869292
111regulation of interleukin-2 biosynthetic process (GO:0045076)2.54771405
112mRNA splice site selection (GO:0006376)2.53713734
113histone H4 deacetylation (GO:0070933)2.52862904
114positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.52701385
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52599787
116regulation of necroptotic process (GO:0060544)2.52339902
117positive T cell selection (GO:0043368)2.52023243
118monoubiquitinated protein deubiquitination (GO:0035520)2.51952370
119positive regulation by host of viral transcription (GO:0043923)2.51866236
120T cell differentiation (GO:0030217)2.51061553
121lymphocyte homeostasis (GO:0002260)2.51050796
122antigen processing and presentation of endogenous antigen (GO:0019883)2.50831369
123regulation of spindle organization (GO:0090224)2.50818340
124interferon-gamma production (GO:0032609)2.50817053
125regulation of alpha-beta T cell differentiation (GO:0046637)2.50607224
126RNA stabilization (GO:0043489)2.50301155
127mRNA stabilization (GO:0048255)2.50301155
128response to protozoan (GO:0001562)2.49654648
129alternative mRNA splicing, via spliceosome (GO:0000380)2.49649276
130DNA conformation change (GO:0071103)2.49537820
131sister chromatid cohesion (GO:0007062)2.49419081
132positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48515573
133histone methylation (GO:0016571)2.47575786
134negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47145071
135negative regulation of translation, ncRNA-mediated (GO:0040033)2.47145071
136regulation of translation, ncRNA-mediated (GO:0045974)2.47145071
137mitotic recombination (GO:0006312)2.46993302
138positive regulation of granulocyte differentiation (GO:0030854)2.46377666
139DNA replication initiation (GO:0006270)2.46231910
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45491633
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45491633
142negative regulation of mRNA metabolic process (GO:1903312)2.45299756
143chromatin assembly or disassembly (GO:0006333)2.44957276
144regulation of DNA damage checkpoint (GO:2000001)2.44702772
145negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.44422632
146negative regulation of cell killing (GO:0031342)2.44422632
147V(D)J recombination (GO:0033151)2.44338438
148DNA strand elongation involved in DNA replication (GO:0006271)2.43679799
149DNA replication-independent nucleosome assembly (GO:0006336)2.43677808
150DNA replication-independent nucleosome organization (GO:0034724)2.43677808
151T cell selection (GO:0045058)2.43632999
152metaphase plate congression (GO:0051310)2.42835355
153positive regulation of B cell differentiation (GO:0045579)2.42810426
154definitive hemopoiesis (GO:0060216)2.42603409
155telomere maintenance via recombination (GO:0000722)2.42515708
156regulation of mitotic spindle organization (GO:0060236)2.41817971
157positive regulation of histone methylation (GO:0031062)2.39730600
158thymic T cell selection (GO:0045061)2.39324450
159regulation of chromatin silencing (GO:0031935)2.38565518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.86042615
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.03656438
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.86652488
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61802750
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.56157083
6* MYC_22102868_ChIP-Seq_BL_Human3.34763296
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.98225633
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91117248
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89389994
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.67090457
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.61748329
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44192749
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35818862
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20491972
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.20182328
16VDR_21846776_ChIP-Seq_THP-1_Human2.19369923
17CIITA_25753668_ChIP-Seq_RAJI_Human2.19242353
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.18987779
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13708383
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13239680
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06858256
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04934277
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.03033895
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.96480290
25* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.95514285
26SCL_19346495_ChIP-Seq_HPC-7_Human1.95272029
27MYB_26560356_Chip-Seq_TH1_Human1.94876508
28TCF7_22412390_ChIP-Seq_EML_Mouse1.91172915
29MYB_26560356_Chip-Seq_TH2_Human1.88826136
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84439010
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.77688402
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.76081850
33MAF_26560356_Chip-Seq_TH1_Human1.74414080
34* UTX_26944678_Chip-Seq_JUKART_Human1.72221233
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68479239
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64104106
37* SPI1_23547873_ChIP-Seq_NB4_Human1.59919554
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59871443
39* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59479118
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58585534
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.54751442
42AR_21572438_ChIP-Seq_LNCaP_Human1.54655752
43RUNX_20019798_ChIP-Seq_JUKART_Human1.48595851
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45401970
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45221385
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45165275
47GATA1_22025678_ChIP-Seq_K562_Human1.43465962
48* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41264473
49* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40088258
50* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39706485
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37671119
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.37016354
53* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36175909
54* KDM5A_27292631_Chip-Seq_BREAST_Human1.35995340
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35531206
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35153554
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.34706007
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33861530
59VDR_24763502_ChIP-Seq_THP-1_Human1.31763559
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31456687
61VDR_24787735_ChIP-Seq_THP-1_Human1.29539782
62* VDR_23849224_ChIP-Seq_CD4+_Human1.29355501
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26945179
64FOXP3_21729870_ChIP-Seq_TREG_Human1.25351321
65KDM2B_26808549_Chip-Seq_DND41_Human1.23233999
66GATA3_26560356_Chip-Seq_TH2_Human1.20687094
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19972933
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19189872
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16986533
70MAF_26560356_Chip-Seq_TH2_Human1.15994817
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14745281
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13596167
73* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12491374
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11677380
75* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11643933
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11323076
77ELK1_19687146_ChIP-ChIP_HELA_Human1.09126289
78* XRN2_22483619_ChIP-Seq_HELA_Human1.07650904
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07487573
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06694033
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05632263
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05573904
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05558811
84* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05166146
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04250658
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03734182
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03255738
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02882024
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99684945
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98701241
91AR_21909140_ChIP-Seq_LNCAP_Human0.97187314
92GATA1_19941826_ChIP-Seq_K562_Human0.97129415
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96206847
94PU_27001747_Chip-Seq_BMDM_Mouse0.95538279
95SPI1_23127762_ChIP-Seq_K562_Human0.94911495
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94479813
97* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94040723
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.91965707
99TTF2_22483619_ChIP-Seq_HELA_Human0.91326241
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90445786
101* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90348707
102GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89005513
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88878863
104GATA3_27048872_Chip-Seq_THYMUS_Human0.88531521
105* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88039378
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88029400
107* TFEB_21752829_ChIP-Seq_HELA_Human0.87814353
108NCOR1_26117541_ChIP-Seq_K562_Human0.87537995
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87519004
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.86730018
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.86021110
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85824180
113PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85483218
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84466105
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82688961
116* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81619556
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80808502
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78738103
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78738103
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78738103
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78363995
122* KDM2B_26808549_Chip-Seq_JURKAT_Human0.78343516
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78257435
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77836259
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77785046
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.76940769
127* SMRT_27268052_Chip-Seq_Bcells_Human0.73373735
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71235070
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.71053991
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.70375822
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69823773
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69504542
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.68601790
134GATA2_19941826_ChIP-Seq_K562_Human0.68597314
135GATA3_26560356_Chip-Seq_TH1_Human0.67354746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.18290660
2MP0010094_abnormal_chromosome_stability3.11558349
3MP0002396_abnormal_hematopoietic_system2.99438531
4MP0000569_abnormal_digit_pigmentation2.96999825
5MP0003693_abnormal_embryo_hatching2.91090197
6MP0003111_abnormal_nucleus_morphology2.87206472
7MP0003077_abnormal_cell_cycle2.76725663
8MP0003763_abnormal_thymus_physiology2.60667677
9MP0001835_abnormal_antigen_presentation2.46609590
10MP0004808_abnormal_hematopoietic_stem2.36397462
11MP0001800_abnormal_humoral_immune2.28842267
12MP0008007_abnormal_cellular_replicative2.25404911
13MP0003787_abnormal_imprinting2.15543261
14MP0008058_abnormal_DNA_repair2.15541430
15MP0002398_abnormal_bone_marrow2.11014946
16MP0002166_altered_tumor_susceptibility2.06619107
17MP0000685_abnormal_immune_system2.06075605
18MP0004957_abnormal_blastocyst_morpholog2.03490130
19MP0009278_abnormal_bone_marrow2.02669950
20MP0005671_abnormal_response_to1.98135784
21MP0005174_abnormal_tail_pigmentation1.94938692
22MP0002006_tumorigenesis1.94309077
23MP0010352_gastrointestinal_tract_polyps1.94023000
24MP0000703_abnormal_thymus_morphology1.87285300
25MP0010307_abnormal_tumor_latency1.86880484
26MP0005076_abnormal_cell_differentiation1.86352823
27MP0002452_abnormal_antigen_presenting1.86113766
28MP0005397_hematopoietic_system_phenotyp1.81053255
29MP0001545_abnormal_hematopoietic_system1.81053255
30MP0005387_immune_system_phenotype1.78615944
31MP0001790_abnormal_immune_system1.78615944
32MP0002420_abnormal_adaptive_immunity1.72572626
33MP0001819_abnormal_immune_cell1.70567047
34MP0002723_abnormal_immune_serum1.70044806
35MP0000689_abnormal_spleen_morphology1.66048947
36MP0000350_abnormal_cell_proliferation1.65791843
37MP0002722_abnormal_immune_system1.65475280
38MP0000716_abnormal_immune_system1.65265681
39MP0008877_abnormal_DNA_methylation1.59363911
40MP0004381_abnormal_hair_follicle1.56081365
41MP0005000_abnormal_immune_tolerance1.54903786
42MP0000490_abnormal_crypts_of1.50113281
43MP0002933_joint_inflammation1.45710541
44MP0001851_eye_inflammation1.44940317
45MP0002429_abnormal_blood_cell1.44546059
46MP0009333_abnormal_splenocyte_physiolog1.41861658
47MP0003121_genomic_imprinting1.40940682
48MP0002405_respiratory_system_inflammati1.34580200
49MP0001730_embryonic_growth_arrest1.30613375
50MP0005025_abnormal_response_to1.27559999
51MP0009115_abnormal_fat_cell1.26299821
52MP0003436_decreased_susceptibility_to1.24398857
53MP0006292_abnormal_olfactory_placode1.23444208
54MP0001873_stomach_inflammation1.22974959
55MP0003172_abnormal_lysosome_physiology1.22759623
56MP0005380_embryogenesis_phenotype1.22574099
57MP0001672_abnormal_embryogenesis/_devel1.22574099
58MP0002019_abnormal_tumor_incidence1.19976922
59MP0009785_altered_susceptibility_to1.18993429
60MP0003303_peritoneal_inflammation1.18653048
61MP0003984_embryonic_growth_retardation1.16831502
62MP0002088_abnormal_embryonic_growth/wei1.15423099
63MP0000313_abnormal_cell_death1.15410960
64MP0002086_abnormal_extraembryonic_tissu1.14205602
65MP0005075_abnormal_melanosome_morpholog1.13195385
66MP0010155_abnormal_intestine_physiology1.12876912
67MP0005310_abnormal_salivary_gland1.11263428
68MP0003183_abnormal_peptide_metabolism1.11252164
69MP0000015_abnormal_ear_pigmentation1.10204649
70MP0003221_abnormal_cardiomyocyte_apopto1.09573931
71MP0004197_abnormal_fetal_growth/weight/1.08359918
72MP0002084_abnormal_developmental_patter1.07746361
73MP0003890_abnormal_embryonic-extraembry1.07043530
74MP0002419_abnormal_innate_immunity1.06947612
75MP0001697_abnormal_embryo_size1.06115136
76MP0001853_heart_inflammation1.05198443
77MP0005464_abnormal_platelet_physiology1.04406565
78MP0005666_abnormal_adipose_tissue1.04259775
79MP0003045_fibrosis1.02222727
80MP0003943_abnormal_hepatobiliary_system1.01975391
81MP0000371_diluted_coat_color1.01112623
82MP0000465_gastrointestinal_hemorrhage1.00383195
83MP0002009_preneoplasia0.99104351
84MP0002085_abnormal_embryonic_tissue0.99005585
85MP0002095_abnormal_skin_pigmentation0.97702375
86MP0003300_gastrointestinal_ulcer0.96548128
87MP0004185_abnormal_adipocyte_glucose0.95759496
88MP0004264_abnormal_extraembryonic_tissu0.93816736
89MP0003567_abnormal_fetal_cardiomyocyte0.93010966
90MP0001293_anophthalmia0.92864806
91MP0002080_prenatal_lethality0.92661739
92MP0002148_abnormal_hypersensitivity_rea0.91987904
93MP0003786_premature_aging0.91775871
94MP0004947_skin_inflammation0.90446259
95MP0008932_abnormal_embryonic_tissue0.88467602
96MP0002998_abnormal_bone_remodeling0.88129138
97MP0008995_early_reproductive_senescence0.87019513
98MP0005375_adipose_tissue_phenotype0.85741124
99MP0003656_abnormal_erythrocyte_physiolo0.84897796
100MP0003866_abnormal_defecation0.83877346
101MP0005451_abnormal_body_composition0.82543679
102MP0002132_abnormal_respiratory_system0.81824102
103MP0003448_altered_tumor_morphology0.81758237
104MP0003724_increased_susceptibility_to0.81477490
105MP0002970_abnormal_white_adipose0.81075529
106MP0001915_intracranial_hemorrhage0.80190709
107MP0000733_abnormal_muscle_development0.79014845
108MP0003091_abnormal_cell_migration0.77674359
109MP0003828_pulmonary_edema0.76206268
110MP0002075_abnormal_coat/hair_pigmentati0.75915760
111MP0001845_abnormal_inflammatory_respons0.75686372
112MP0000858_altered_metastatic_potential0.74992249
113MP0002928_abnormal_bile_duct0.73586710
114MP0004130_abnormal_muscle_cell0.73074090
115MP0001348_abnormal_lacrimal_gland0.72630617
116MP0002925_abnormal_cardiovascular_devel0.72542982
117MP0008961_abnormal_basal_metabolism0.72296463
118MP0002971_abnormal_brown_adipose0.71837701
119MP0005621_abnormal_cell_physiology0.70555661
120MP0003123_paternal_imprinting0.70277754
121MP0001849_ear_inflammation0.70265883
122MP0009703_decreased_birth_body0.67442626
123MP0010630_abnormal_cardiac_muscle0.66820643
124MP0004510_myositis0.63309429
125MP0002092_abnormal_eye_morphology0.63015292
126MP0000003_abnormal_adipose_tissue0.62089342
127MP0005334_abnormal_fat_pad0.61336178
128MP0005220_abnormal_exocrine_pancreas0.59197695
129MP0001784_abnormal_fluid_regulation0.56227247
130MP0004043_abnormal_pH_regulation0.55853860

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.71385173
2Volvulus (HP:0002580)3.89532427
3Chromsome breakage (HP:0040012)3.31577659
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20858737
5Recurrent viral infections (HP:0004429)3.12315449
6Papilledema (HP:0001085)3.02021999
7Hypoplasia of the thymus (HP:0000778)3.01628186
8Granulocytopenia (HP:0001913)3.00716663
9Lip pit (HP:0100267)2.97793718
10Ectopic kidney (HP:0000086)2.81320768
11Long eyelashes (HP:0000527)2.76342977
12Acute myeloid leukemia (HP:0004808)2.73376700
13Viral hepatitis (HP:0006562)2.71595319
14Recurrent fungal infections (HP:0002841)2.68985579
15Thyroiditis (HP:0100646)2.67780350
16Autoimmune hemolytic anemia (HP:0001890)2.67584328
17T lymphocytopenia (HP:0005403)2.66471397
18Fatigue (HP:0012378)2.64681370
19Agammaglobulinemia (HP:0004432)2.63782655
20Truncal obesity (HP:0001956)2.63084435
21Recurrent bronchitis (HP:0002837)2.61470312
22Panhypogammaglobulinemia (HP:0003139)2.57230457
23Abnormality of eosinophils (HP:0001879)2.55666677
24Abnormality of T cell number (HP:0011839)2.53696088
25Myelodysplasia (HP:0002863)2.53482875
26Prominent nose (HP:0000448)2.52295043
27Aplasia/Hypoplasia of the thymus (HP:0010515)2.46125324
28Abnormal delayed hypersensitivity skin test (HP:0002963)2.43863476
29IgM deficiency (HP:0002850)2.42593013
30Eczematoid dermatitis (HP:0000976)2.37964327
31Encephalitis (HP:0002383)2.32764978
32Anal stenosis (HP:0002025)2.32204236
33Genetic anticipation (HP:0003743)2.31109175
34Chronic mucocutaneous candidiasis (HP:0002728)2.30721026
35Recurrent cutaneous fungal infections (HP:0011370)2.30721026
36Gastrointestinal stroma tumor (HP:0100723)2.30666026
37Abnormality of chromosome stability (HP:0003220)2.29323972
38Retrobulbar optic neuritis (HP:0100654)2.28880957
39Optic neuritis (HP:0100653)2.28880957
40Mediastinal lymphadenopathy (HP:0100721)2.28415086
41Autoimmune thrombocytopenia (HP:0001973)2.28295186
42Dislocated radial head (HP:0003083)2.28272660
43Chronic otitis media (HP:0000389)2.27579099
44Stomach cancer (HP:0012126)2.25999772
45Syringomyelia (HP:0003396)2.25767158
46Spinal cord lesions (HP:0100561)2.25767158
47Increased IgE level (HP:0003212)2.24632909
48Lymphoma (HP:0002665)2.23256918
49Abnormality of T cells (HP:0002843)2.21009847
50Cellulitis (HP:0100658)2.18747166
51Leukocytosis (HP:0001974)2.16311930
52Acute lymphatic leukemia (HP:0006721)2.15086762
53Medulloblastoma (HP:0002885)2.14872792
54Birth length less than 3rd percentile (HP:0003561)2.13782814
55Increased nuchal translucency (HP:0010880)2.13630697
56Broad alveolar ridges (HP:0000187)2.13246379
57Cutis marmorata (HP:0000965)2.12183297
58Stomatitis (HP:0010280)2.12083831
59Abnormality of the radial head (HP:0003995)2.10601421
60Supernumerary bones of the axial skeleton (HP:0009144)2.10386247
61B lymphocytopenia (HP:0010976)2.09379343
62Abnormality of B cell number (HP:0010975)2.09379343
63Gastrointestinal infarctions (HP:0005244)2.09216052
64Lymphopenia (HP:0001888)2.08908925
65Absent frontal sinuses (HP:0002688)2.07488495
66Severe combined immunodeficiency (HP:0004430)2.06249853
67Thrombocytosis (HP:0001894)2.06202864
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06171248
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.05512922
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05218029
71Short 4th metacarpal (HP:0010044)2.05218029
72Amaurosis fugax (HP:0100576)2.04868308
73Deep palmar crease (HP:0006191)2.04538594
74Proximal placement of thumb (HP:0009623)2.04208376
75Acute hepatic failure (HP:0006554)2.02542987
76Orchitis (HP:0100796)2.02200996
77Meningitis (HP:0001287)2.01747261
78Urethral obstruction (HP:0000796)2.01279441
79Abnormality of the thymus (HP:0000777)2.00264074
80Thick eyebrow (HP:0000574)2.00255404
81Recurrent sinusitis (HP:0011108)1.99887239
82Verrucae (HP:0200043)1.99305300
83Papilloma (HP:0012740)1.99305300
84Deviation of the thumb (HP:0009603)1.98170197
85Aplasia/Hypoplasia of the uvula (HP:0010293)1.97551970
86Combined immunodeficiency (HP:0005387)1.97125081
87Tapered finger (HP:0001182)1.97030326
88Abnormality of DNA repair (HP:0003254)1.96606298
89Recurrent abscess formation (HP:0002722)1.96246156
90Basal cell carcinoma (HP:0002671)1.96179090
91IgA deficiency (HP:0002720)1.95950279
92Elevated erythrocyte sedimentation rate (HP:0003565)1.95373484
93Hematochezia (HP:0002573)1.95245073
94Trigonocephaly (HP:0000243)1.95216245
95Deep philtrum (HP:0002002)1.93647210
96Clubbing of toes (HP:0100760)1.93258547
97IgG deficiency (HP:0004315)1.93171110
98Myositis (HP:0100614)1.92781316
99Abnormality of the preputium (HP:0100587)1.90970046
100Skin tags (HP:0010609)1.90442385
101Depressed nasal tip (HP:0000437)1.90184674
102Meckel diverticulum (HP:0002245)1.89670263
103Pustule (HP:0200039)1.89361173
104Short chin (HP:0000331)1.89140058
105Abnormality of the ileum (HP:0001549)1.89079801
106Neoplasm of the tracheobronchial system (HP:0100552)1.88816253
107Recurrent bacterial skin infections (HP:0005406)1.88523407
108Neoplasm of the oral cavity (HP:0100649)1.87251938
109Keratoconjunctivitis sicca (HP:0001097)1.87215820
110Reticulocytopenia (HP:0001896)1.86695186
111Tented upper lip vermilion (HP:0010804)1.86349557
112Heterotopia (HP:0002282)1.85971015
113Abnormality of the pons (HP:0007361)1.85496110
114Patellar aplasia (HP:0006443)1.85425840
115Hypoplasia of the pons (HP:0012110)1.84875325
116Hepatitis (HP:0012115)1.84327987
117Pulmonary infiltrates (HP:0002113)1.82051728
118Narrow palate (HP:0000189)1.81790170
119Broad palm (HP:0001169)1.81094358
120Abnormality of T cell physiology (HP:0011840)1.79602966
121Abnormal number of incisors (HP:0011064)1.79054098
122Hypoplastic iliac wings (HP:0002866)1.78881568
123Poikiloderma (HP:0001029)1.78087822
124Leukopenia (HP:0001882)1.78004013
125Inflammation of the large intestine (HP:0002037)1.77242485
126Gastrointestinal inflammation (HP:0004386)1.77012447
127Chronic diarrhea (HP:0002028)1.76870811
128Subacute progressive viral hepatitis (HP:0006572)1.74989487
129Chest pain (HP:0100749)1.74971409
130Abnormality of the carotid arteries (HP:0005344)1.73057386
131Intestinal fistula (HP:0100819)1.72907939
132* Sandal gap (HP:0001852)1.72258588
133Supernumerary ribs (HP:0005815)1.71980222
134Sparse lateral eyebrow (HP:0005338)1.71843520
135Recurrent skin infections (HP:0001581)1.70627477
136Cerebellar dysplasia (HP:0007033)1.70509404
137Ependymoma (HP:0002888)1.68712739
138Vasculitis (HP:0002633)1.68214971
139Abnormality of the renal collecting system (HP:0004742)1.67613820
140Albinism (HP:0001022)1.67345239
141Periodontitis (HP:0000704)1.64791712
142Cafe-au-lait spot (HP:0000957)1.64706285
143Macroorchidism (HP:0000053)1.64072014
144Aplasia/Hypoplasia of the patella (HP:0006498)1.62598457
145Colitis (HP:0002583)1.61731099
146Hypochromic microcytic anemia (HP:0004840)1.61415741
147Low anterior hairline (HP:0000294)1.61365543
148Eosinophilia (HP:0001880)1.61138441
149Abnormality of the nasal septum (HP:0000419)1.61030708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.77610623
2MAP4K13.75239773
3CDC72.80026716
4EEF2K2.56078539
5MAP3K102.42569735
6NEK22.35040426
7BRD42.33677425
8TXK2.33672394
9PRPF4B2.25350047
10JAK32.01446362
11TYK21.83567484
12STK101.83420943
13MAP3K141.81990213
14NLK1.75466350
15SRPK11.72633566
16ATR1.72197647
17ERN11.62629622
18SIK21.58718092
19CAMK1G1.56222382
20BLK1.47422302
21CAMK1D1.44255890
22FGFR31.43696890
23RPS6KB21.40422395
24MAP3K131.36200337
25CDK61.34747708
26KIT1.33357096
27CDK41.31518131
28TEC1.29730835
29CHUK1.29185678
30MKNK21.28127363
31PIM11.27652516
32AKT31.22158908
33TTK1.21861778
34ZAP701.20581906
35BTK1.20108444
36MKNK11.19179549
37JAK11.17147744
38IKBKE1.16589262
39BMPR21.15714157
40CDC42BPA1.15107264
41CDK71.14958560
42CHEK11.12775408
43CDK91.11138084
44PKN21.08744342
45ATM1.08528850
46CSF1R1.07297423
47MARK21.03955073
48TYRO31.03229511
49TRIB31.02966904
50LATS11.01439002
51ALK1.00889497
52YES10.99826881
53STK40.99597261
54AURKB0.98751868
55GRK60.98313615
56CHEK20.97834683
57LCK0.97789795
58IRAK40.97542012
59IRAK30.97214365
60WNK10.96842173
61FES0.96584183
62MARK30.95915453
63IKBKB0.95223973
64TGFBR10.94811676
65SYK0.94438056
66IRAK10.94158688
67RPS6KA40.93710364
68HCK0.92997625
69ITK0.92394068
70TNK20.92338161
71STK30.91517405
72PASK0.90587080
73TAOK30.90056053
74CAMKK10.89000598
75PLK10.88190397
76ACVR1B0.86329241
77* CDK20.85505613
78TRPM70.85228820
79TSSK60.83173917
80CLK10.82110019
81CSK0.81677605
82MTOR0.81589091
83MAPK70.81546709
84PLK40.80636286
85TBK10.78314378
86MAP3K60.78242224
87FGFR40.77472230
88NUAK10.75597900
89WEE10.74674042
90MELK0.74204021
91DYRK30.74086745
92FRK0.73945890
93JAK20.71644641
94EPHA30.71347571
95SIK10.71177785
96CAMKK20.70209310
97LYN0.69045700
98FGFR20.68608811
99MAPK150.68093806
100SGK20.66308350
101MAPK120.64722728
102CDK10.62983267
103RIPK40.62640038
104STK110.60645068
105PIK3CG0.58813321
106PLK30.58654325
107PDK10.56262399
108* MAPK140.55709700
109MAP3K80.54912926
110MATK0.54903798
111TGFBR20.54751906
112ICK0.54027194
113SIK30.53127260
114LRRK20.51673990
115MAPK100.51391151
116MAPK30.51199012
117MAP2K30.51068242
118SGK30.50873653
119PRKD20.50606463
120PTK60.49657148
121DYRK1A0.49577175
122PRKCH0.48316368
123PRKDC0.47762358
124MAPK110.47678330
125HIPK20.47522383
126PDGFRB0.47173706
127CDK30.47101880
128BRSK20.46781449
129RET0.46482323
130EIF2AK30.45935811
131FLT30.45874074
132PRKCQ0.45407921
133MAPK10.45343276
134CAMK40.45077676
135SGK10.44681324
136VRK10.42396795
137ERBB30.41950579
138MAP3K70.41196344
139EIF2AK20.40614509

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.53893488
2Primary immunodeficiency_Homo sapiens_hsa053402.50859514
3Mismatch repair_Homo sapiens_hsa034302.19052605
4Spliceosome_Homo sapiens_hsa030402.12352862
5Base excision repair_Homo sapiens_hsa034101.99685938
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.91677940
7Cell cycle_Homo sapiens_hsa041101.87823667
8B cell receptor signaling pathway_Homo sapiens_hsa046621.84137286
9Herpes simplex infection_Homo sapiens_hsa051681.84053063
10Fanconi anemia pathway_Homo sapiens_hsa034601.81414603
11Non-homologous end-joining_Homo sapiens_hsa034501.79458649
12mRNA surveillance pathway_Homo sapiens_hsa030151.79153370
13Measles_Homo sapiens_hsa051621.77327894
14RNA transport_Homo sapiens_hsa030131.73660967
15Homologous recombination_Homo sapiens_hsa034401.69027641
16RNA degradation_Homo sapiens_hsa030181.67740877
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65432788
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.54363656
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44308374
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.42634750
21Leishmaniasis_Homo sapiens_hsa051401.41542529
22Antigen processing and presentation_Homo sapiens_hsa046121.39440603
23Hematopoietic cell lineage_Homo sapiens_hsa046401.37977688
24T cell receptor signaling pathway_Homo sapiens_hsa046601.37840034
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37578193
26p53 signaling pathway_Homo sapiens_hsa041151.36326619
27Osteoclast differentiation_Homo sapiens_hsa043801.36237819
28Influenza A_Homo sapiens_hsa051641.32575588
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30978888
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28056173
31MicroRNAs in cancer_Homo sapiens_hsa052061.25114176
32Lysine degradation_Homo sapiens_hsa003101.22378289
33Hepatitis B_Homo sapiens_hsa051611.21679426
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20402530
35Chronic myeloid leukemia_Homo sapiens_hsa052201.20310948
36Notch signaling pathway_Homo sapiens_hsa043301.18574551
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.18411628
38Nucleotide excision repair_Homo sapiens_hsa034201.17189920
39HTLV-I infection_Homo sapiens_hsa051661.16407391
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15485846
41Acute myeloid leukemia_Homo sapiens_hsa052211.15267345
42Small cell lung cancer_Homo sapiens_hsa052221.14771187
43Dorso-ventral axis formation_Homo sapiens_hsa043201.13996924
44Epstein-Barr virus infection_Homo sapiens_hsa051691.13591648
45Choline metabolism in cancer_Homo sapiens_hsa052311.13366880
46One carbon pool by folate_Homo sapiens_hsa006701.11483424
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10571665
48Viral carcinogenesis_Homo sapiens_hsa052031.07634203
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07350589
50Graft-versus-host disease_Homo sapiens_hsa053321.04842418
51Viral myocarditis_Homo sapiens_hsa054161.03971643
52Allograft rejection_Homo sapiens_hsa053301.02003294
53Renal cell carcinoma_Homo sapiens_hsa052111.00898190
54TNF signaling pathway_Homo sapiens_hsa046681.00207857
55Toxoplasmosis_Homo sapiens_hsa051450.97725865
56Insulin resistance_Homo sapiens_hsa049310.95206337
57Colorectal cancer_Homo sapiens_hsa052100.94833599
58Apoptosis_Homo sapiens_hsa042100.94804686
59Chemokine signaling pathway_Homo sapiens_hsa040620.91373445
60Pancreatic cancer_Homo sapiens_hsa052120.90686386
61mTOR signaling pathway_Homo sapiens_hsa041500.89712064
62ErbB signaling pathway_Homo sapiens_hsa040120.89415133
63Staphylococcus aureus infection_Homo sapiens_hsa051500.88595074
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85858162
65VEGF signaling pathway_Homo sapiens_hsa043700.84809422
66Circadian rhythm_Homo sapiens_hsa047100.83194281
67Legionellosis_Homo sapiens_hsa051340.81460278
68Basal transcription factors_Homo sapiens_hsa030220.80441738
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.79202173
70RNA polymerase_Homo sapiens_hsa030200.78133517
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77704200
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77546618
73Non-small cell lung cancer_Homo sapiens_hsa052230.74412221
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73612480
75Platelet activation_Homo sapiens_hsa046110.73309320
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72790548
77Other glycan degradation_Homo sapiens_hsa005110.72769438
78Type II diabetes mellitus_Homo sapiens_hsa049300.72551142
79Prostate cancer_Homo sapiens_hsa052150.72507905
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.71967196
81Prolactin signaling pathway_Homo sapiens_hsa049170.71751032
82Tuberculosis_Homo sapiens_hsa051520.70860003
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70356402
84Shigellosis_Homo sapiens_hsa051310.70356184
85Hepatitis C_Homo sapiens_hsa051600.70312122
86ABC transporters_Homo sapiens_hsa020100.69697962
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68518717
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.68382022
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68122199
90Pyrimidine metabolism_Homo sapiens_hsa002400.67821209
91Adherens junction_Homo sapiens_hsa045200.67789958
92Ribosome_Homo sapiens_hsa030100.67590382
93FoxO signaling pathway_Homo sapiens_hsa040680.67274590
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.65402596
95GnRH signaling pathway_Homo sapiens_hsa049120.64931255
96Systemic lupus erythematosus_Homo sapiens_hsa053220.63257424
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.63070150
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62214524
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62199838
100African trypanosomiasis_Homo sapiens_hsa051430.61938781
101Pathways in cancer_Homo sapiens_hsa052000.60840328
102Glioma_Homo sapiens_hsa052140.60355104
103Endometrial cancer_Homo sapiens_hsa052130.59788340
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59472519
105Estrogen signaling pathway_Homo sapiens_hsa049150.58454543
106Autoimmune thyroid disease_Homo sapiens_hsa053200.58188471
107Inositol phosphate metabolism_Homo sapiens_hsa005620.55631398
108Proteoglycans in cancer_Homo sapiens_hsa052050.55168210
109MAPK signaling pathway_Homo sapiens_hsa040100.53447094
110Basal cell carcinoma_Homo sapiens_hsa052170.50573109
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50356834
112Asthma_Homo sapiens_hsa053100.50332892
113TGF-beta signaling pathway_Homo sapiens_hsa043500.50313759
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49890713
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49508511
116Malaria_Homo sapiens_hsa051440.48870292
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47404800
118Type I diabetes mellitus_Homo sapiens_hsa049400.47373830
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46375756
120HIF-1 signaling pathway_Homo sapiens_hsa040660.44711634
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43365105
122Salmonella infection_Homo sapiens_hsa051320.42582666
123Thyroid cancer_Homo sapiens_hsa052160.42484858
124Long-term potentiation_Homo sapiens_hsa047200.40526156
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40405771
126Pertussis_Homo sapiens_hsa051330.40382438
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.40345486

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