ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of mammary gland epithelial cell proliferation (GO:0033599)	5.39828881
2	ribosomal small subunit biogenesis (GO:0042274)	4.94407309
3	regulation of early endosome to late endosome transport (GO:2000641)	4.21352136
4	cell-cell junction maintenance (GO:0045217)	4.08412283
5	proline biosynthetic process (GO:0006561)	4.07330697
6	protein retention in ER lumen (GO:0006621)	4.02684515
7	diaphragm development (GO:0060539)	3.98136115
8	viral transcription (GO:0019083)	3.91772738
9	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	3.89641541
10	protein maturation by protein folding (GO:0022417)	3.79223725
11	skeletal muscle organ development (GO:0060538)	3.73472676
12	apoptotic process involved in morphogenesis (GO:0060561)	3.68704397
13	melanin biosynthetic process (GO:0042438)	3.64138535
14	pentose metabolic process (GO:0019321)	3.60415995
15	heterochromatin organization (GO:0070828)	3.57738960
16	peptidyl-arginine omega-N-methylation (GO:0035247)	3.57335870
17	translational termination (GO:0006415)	3.54604881
18	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.54039505
19	ribosomal small subunit assembly (GO:0000028)	3.49720197
20	protein complex localization (GO:0031503)	3.45665219
21	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.41378545
22	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.40816197
23	histone arginine methylation (GO:0034969)	3.37529647
24	post-embryonic morphogenesis (GO:0009886)	3.28655487
25	translational elongation (GO:0006414)	3.28533778
26	negative regulation of cell size (GO:0045792)	3.18985985
27	melanin metabolic process (GO:0006582)	3.14640955
28	ncRNA 3-end processing (GO:0043628)	3.09445923
29	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.09442719
30	tooth mineralization (GO:0034505)	3.05865347
31	L-serine metabolic process (GO:0006563)	3.05582147
32	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	3.02468454
33	respiratory system process (GO:0003016)	3.01088399
34	negative regulation of erythrocyte differentiation (GO:0045647)	2.99521666
35	regulation of translational fidelity (GO:0006450)	2.99176660
36	adherens junction assembly (GO:0034333)	2.95452054
37	adenine nucleotide transport (GO:0051503)	2.90655711
38	cerebellar Purkinje cell layer development (GO:0021680)	2.90623270
39	maternal placenta development (GO:0001893)	2.89437987
40	viral life cycle (GO:0019058)	2.88602085
41	response to parathyroid hormone (GO:0071107)	2.85455406
42	amyloid precursor protein catabolic process (GO:0042987)	2.83666626
43	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.83067106
44	cell junction maintenance (GO:0034331)	2.81776413
45	glucose 6-phosphate metabolic process (GO:0051156)	2.80906821
46	mitochondrion transport along microtubule (GO:0047497)	2.80803555
47	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.80803555
48	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.80595545
49	cellular protein complex localization (GO:0034629)	2.79215308
50	outflow tract septum morphogenesis (GO:0003148)	2.78817284
51	peptidyl-arginine methylation (GO:0018216)	2.76558917
52	peptidyl-arginine N-methylation (GO:0035246)	2.76558917
53	protein insertion into membrane (GO:0051205)	2.75698419
54	protein targeting to ER (GO:0045047)	2.75666227
55	formation of translation preinitiation complex (GO:0001731)	2.75315788
56	epithelial cell-cell adhesion (GO:0090136)	2.75269279
57	cotranslational protein targeting to membrane (GO:0006613)	2.73839236
58	cellular protein complex disassembly (GO:0043624)	2.73441253
59	pentose-phosphate shunt (GO:0006098)	2.73096082
60	outer ear morphogenesis (GO:0042473)	2.72637498
61	GDP-mannose metabolic process (GO:0019673)	2.70382776
62	rRNA transcription (GO:0009303)	2.69034975
63	cell migration in hindbrain (GO:0021535)	2.66387068
64	positive regulation of synapse maturation (GO:0090129)	2.65888030
65	lymph vessel development (GO:0001945)	2.65418925
66	negative regulation of microtubule polymerization (GO:0031115)	2.64739474
67	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	2.63684171
68	protein localization to endoplasmic reticulum (GO:0070972)	2.62305573
69	apoptotic process involved in development (GO:1902742)	2.61343334
70	proline metabolic process (GO:0006560)	2.60796876
71	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.59244751
72	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.59076359
73	protein complex disassembly (GO:0043241)	2.57959382
74	regulation of mitochondrial translation (GO:0070129)	2.57292831
75	translational initiation (GO:0006413)	2.55656602
76	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.53940971
77	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.52818282
78	glucose catabolic process (GO:0006007)	2.52674083
79	negative regulation of telomerase activity (GO:0051974)	2.52532345
80	regulation of chromatin binding (GO:0035561)	2.51560259
81	modulation by virus of host process (GO:0019054)	2.51481043
82	establishment of apical/basal cell polarity (GO:0035089)	2.49392048
83	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.49180425
84	ribonucleoprotein complex biogenesis (GO:0022613)	2.45882996
85	cell-substrate adherens junction assembly (GO:0007045)	2.45402716
86	focal adhesion assembly (GO:0048041)	2.45402716
87	modulation by virus of host morphology or physiology (GO:0019048)	2.44840889
88	pseudouridine synthesis (GO:0001522)	2.43827070
89	nucleobase-containing small molecule interconversion (GO:0015949)	2.42149028
90	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.41501809
91	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.40976387
92	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.40831216
93	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.40804432
94	dopamine receptor signaling pathway (GO:0007212)	2.40205796
95	cellular component maintenance (GO:0043954)	2.40196992
96	purine nucleotide transport (GO:0015865)	2.39954347
97	cerebellar granule cell differentiation (GO:0021707)	2.39538643
98	mitotic chromosome condensation (GO:0007076)	2.39124260
99	secondary metabolite biosynthetic process (GO:0044550)	2.39107697
100	adhesion of symbiont to host (GO:0044406)	2.38713369

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.75959546
2	LXR_22292898_ChIP-Seq_THP-1_Human	2.76930641
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.48593263
4	VDR_21846776_ChIP-Seq_THP-1_Human	2.36056145
5	RACK7_27058665_Chip-Seq_MCF-7_Human	2.30358384
6	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.29014122
7	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.24729264
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.16364722
9	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	2.12214319
10	MYC_22102868_ChIP-Seq_BL_Human	2.07875046
11	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.07589564
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.02977570
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.01742577
14	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.96690101
15	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.93522665
16	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.92498617
17	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.90229567
18	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.88058991
19	KDM2B_26808549_Chip-Seq_K562_Human	1.85223033
20	P68_20966046_ChIP-Seq_HELA_Human	1.83813874
21	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.82602533
22	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.80359554
23	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.75598336
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.75047150
25	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.74504867
26	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.74074259
27	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.72951705
28	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.72360462
29	KDM2B_26808549_Chip-Seq_DND41_Human	1.69089006
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.65099032
31	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.64958790
32	XRN2_22483619_ChIP-Seq_HELA_Human	1.62116928
33	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.61526372
34	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.61521833
35	E2F7_22180533_ChIP-Seq_HELA_Human	1.58143737
36	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.56537593
37	SMC4_20622854_ChIP-Seq_HELA_Human	1.56144283
38	CREB1_26743006_Chip-Seq_LNCaP_Human	1.52197509
39	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.51871218
40	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.51313823
41	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.49144375
42	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.48412988
43	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.48163562
44	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.47305242
45	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.46597619
46	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.44064550
47	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.43598576
48	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.43516852
49	CTCF_27219007_Chip-Seq_Bcells_Human	1.43346161
50	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.39374919
51	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.38420893
52	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.36716880
53	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.36159125
54	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.35338104
55	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.34865120
56	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.33987508
57	TCF7_22412390_ChIP-Seq_EML_Mouse	1.31363298
58	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.30174007
59	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.28834064
60	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.28724017
61	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.28640492
62	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.27606060
63	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.26532961
64	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.26009331
65	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.23545622
66	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.21265642
67	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.19893907
68	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.19353644
69	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.18972687
70	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.18443559
71	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.17739509
72	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.17651776
73	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.16836005
74	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.16513667
75	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.16196393
76	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.15542508
77	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.13872590
78	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.12685111
79	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.09482853
80	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.08770868
81	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.07911086
82	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.07027417
83	BCOR_27268052_Chip-Seq_Bcells_Human	1.06350613
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.06071964
85	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.05583154
86	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.04812586
87	ATF3_27146783_Chip-Seq_COLON_Human	1.02499700
88	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.02108744
89	SA1_27219007_Chip-Seq_Bcells_Human	1.01237750
90	BCL6_27268052_Chip-Seq_Bcells_Human	1.00764051
91	PHF8_20622854_ChIP-Seq_HELA_Human	1.00538929
92	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.00238418
93	CTCF_21964334_Chip-Seq_Bcells_Human	0.97719479
94	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.97545125
95	NCOR1_26117541_ChIP-Seq_K562_Human	0.97272927
96	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.96890478
97	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.95763854
98	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.95373888
99	CTCF_20526341_ChIP-Seq_ESCs_Human	0.95258484
100	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.94965663

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003123_paternal_imprinting	3.99500562
2	MP0005058_abnormal_lysosome_morphology	3.91590128
3	MP0003705_abnormal_hypodermis_morpholog	3.88514084
4	MP0004858_abnormal_nervous_system	3.32719388
5	MP0002249_abnormal_larynx_morphology	2.97492473
6	MP0005451_abnormal_body_composition	2.61386782
7	MP0010030_abnormal_orbit_morphology	2.42947388
8	MP0000678_abnormal_parathyroid_gland	2.38655087
9	MP0002877_abnormal_melanocyte_morpholog	2.33129312
10	MP0009379_abnormal_foot_pigmentation	2.20892468
11	MP0005409_darkened_coat_color	2.19432920
12	MP0001849_ear_inflammation	2.14298868
13	MP0003172_abnormal_lysosome_physiology	2.08368418
14	MP0000537_abnormal_urethra_morphology	2.04871017
15	MP0005623_abnormal_meninges_morphology	2.03348792
16	MP0004859_abnormal_synaptic_plasticity	1.92989116
17	MP0001188_hyperpigmentation	1.91647098
18	MP0003136_yellow_coat_color	1.88629213
19	MP0004185_abnormal_adipocyte_glucose	1.82086157
20	MP0001346_abnormal_lacrimal_gland	1.77721473
21	MP0004233_abnormal_muscle_weight	1.74364049
22	MP0003942_abnormal_urinary_system	1.73403596
23	MP0004381_abnormal_hair_follicle	1.71695744
24	MP0005257_abnormal_intraocular_pressure	1.68493407
25	MP0005076_abnormal_cell_differentiation	1.68307606
26	MP0002796_impaired_skin_barrier	1.64396399
27	MP0005377_hearing/vestibular/ear_phenot	1.56580912
28	MP0003878_abnormal_ear_physiology	1.56580912
29	MP0008260_abnormal_autophagy	1.55469711
30	MP0000015_abnormal_ear_pigmentation	1.55198770
31	MP0002089_abnormal_postnatal_growth/wei	1.54833685
32	MP0000566_synostosis	1.54473385
33	MP0000462_abnormal_digestive_system	1.49882440
34	MP0000681_abnormal_thyroid_gland	1.42532633
35	MP0005501_abnormal_skin_physiology	1.41130715
36	MP0003329_amyloid_beta_deposits	1.37074843
37	MP0001730_embryonic_growth_arrest	1.30513044
38	MP0000049_abnormal_middle_ear	1.27440887
39	MP0009672_abnormal_birth_weight	1.25754346
40	MP0002163_abnormal_gland_morphology	1.22702167
41	MP0009278_abnormal_bone_marrow	1.22232407
42	MP0009840_abnormal_foam_cell	1.19838201
43	MP0004133_heterotaxia	1.18634704
44	MP0003879_abnormal_hair_cell	1.17844192
45	MP0003283_abnormal_digestive_organ	1.17788803
46	MP0000579_abnormal_nail_morphology	1.17613466
47	MP0003315_abnormal_perineum_morphology	1.17030301
48	MP0003183_abnormal_peptide_metabolism	1.11903868
49	MP0003453_abnormal_keratinocyte_physiol	1.10256103
50	MP0003111_abnormal_nucleus_morphology	1.09302286
51	MP0003693_abnormal_embryo_hatching	1.07030294
52	MP0000534_abnormal_ureter_morphology	1.04417740
53	MP0004957_abnormal_blastocyst_morpholog	1.03567509
54	MP0003634_abnormal_glial_cell	1.01353943
55	MP0008932_abnormal_embryonic_tissue	0.98405913
56	MP0009250_abnormal_appendicular_skeleto	0.96953877
57	MP0002822_catalepsy	0.95914787
58	MP0003635_abnormal_synaptic_transmissio	0.95541533
59	MP0005646_abnormal_pituitary_gland	0.94265230
60	MP0005670_abnormal_white_adipose	0.90746625
61	MP0005075_abnormal_melanosome_morpholog	0.89132184
62	MP0002075_abnormal_coat/hair_pigmentati	0.86921458
63	MP0005508_abnormal_skeleton_morphology	0.86666118
64	MP0005083_abnormal_biliary_tract	0.86491051
65	MP0002697_abnormal_eye_size	0.86196207
66	MP0009053_abnormal_anal_canal	0.86187208
67	MP0000733_abnormal_muscle_development	0.85279432
68	MP0002080_prenatal_lethality	0.83718832
69	MP0002085_abnormal_embryonic_tissue	0.83373499
70	MP0002064_seizures	0.82400947
71	MP0005171_absent_coat_pigmentation	0.81929798
72	MP0000350_abnormal_cell_proliferation	0.81757118
73	MP0000639_abnormal_adrenal_gland	0.81718038
74	MP0003115_abnormal_respiratory_system	0.80312054
75	MP0001186_pigmentation_phenotype	0.78976442
76	MP0003861_abnormal_nervous_system	0.77539419
77	MP0002098_abnormal_vibrissa_morphology	0.76738714
78	MP0009384_cardiac_valve_regurgitation	0.75963007
79	MP0003938_abnormal_ear_development	0.74698028
80	MP0002114_abnormal_axial_skeleton	0.73136806
81	MP0002116_abnormal_craniofacial_bone	0.73014854
82	MP0000538_abnormal_urinary_bladder	0.72282382
83	MP0001919_abnormal_reproductive_system	0.71740244
84	MP0000955_abnormal_spinal_cord	0.71477552
85	MP0002736_abnormal_nociception_after	0.70709192
86	MP0008438_abnormal_cutaneous_collagen	0.69245506
87	MP0003077_abnormal_cell_cycle	0.67182458
88	MP0005666_abnormal_adipose_tissue	0.67135121
89	MP0004272_abnormal_basement_membrane	0.66189201
90	MP0002160_abnormal_reproductive_system	0.66109320
91	MP0001672_abnormal_embryogenesis/_devel	0.65424784
92	MP0005380_embryogenesis_phenotype	0.65424784
93	MP0002111_abnormal_tail_morphology	0.64361804
94	MP0001697_abnormal_embryo_size	0.64214712
95	MP0003880_abnormal_central_pattern	0.63591653
96	MP0004264_abnormal_extraembryonic_tissu	0.63037451
97	MP0001968_abnormal_touch/_nociception	0.62604948
98	MP0005423_abnormal_somatic_nervous	0.60785027
99	MP0002152_abnormal_brain_morphology	0.60513850
100	MP0002932_abnormal_joint_morphology	0.59596836

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperthyroidism (HP:0000836)	3.83209880
2	Truncus arteriosus (HP:0001660)	3.69582821
3	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.56744702
4	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.40677980
5	Increased cerebral lipofuscin (HP:0011813)	3.39182705
6	Abnormal ventriculo-arterial connection (HP:0011563)	3.16664423
7	Transposition of the great arteries (HP:0001669)	3.16664423
8	Abnormal connection of the cardiac segments (HP:0011545)	3.16664423
9	Septate vagina (HP:0001153)	3.16108479
10	Broad distal phalanx of finger (HP:0009836)	3.15809688
11	Hyperacusis (HP:0010780)	3.14722777
12	Testicular atrophy (HP:0000029)	2.99073349
13	Abnormality of the aortic arch (HP:0012303)	2.81646235
14	Congenital malformation of the right heart (HP:0011723)	2.80664338
15	Double outlet right ventricle (HP:0001719)	2.80664338
16	Reticulocytopenia (HP:0001896)	2.64732583
17	Germ cell neoplasia (HP:0100728)	2.64193073
18	Hypoplastic left heart (HP:0004383)	2.52535380
19	Ulnar bowing (HP:0003031)	2.47197553
20	Hyperparathyroidism (HP:0000843)	2.43701644
21	Stridor (HP:0010307)	2.42547226
22	Visual hallucinations (HP:0002367)	2.42515004
23	Hypercortisolism (HP:0001578)	2.41748330
24	Achilles tendon contracture (HP:0001771)	2.41683083
25	Premature skin wrinkling (HP:0100678)	2.41185850
26	Myokymia (HP:0002411)	2.40547906
27	Testicular neoplasm (HP:0010788)	2.38895169
28	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.38123941
29	Insomnia (HP:0100785)	2.37497480
30	Hypokinesia (HP:0002375)	2.36425780
31	Abnormality of the thoracic spine (HP:0100711)	2.30460268
32	Abnormality of cells of the erythroid lineage (HP:0012130)	2.28812150
33	Shallow orbits (HP:0000586)	2.27514209
34	Abnormal large intestine physiology (HP:0012700)	2.26034921
35	Bowel incontinence (HP:0002607)	2.24964702
36	Patellar dislocation (HP:0002999)	2.24627084
37	Abnormal umbilical cord blood vessels (HP:0011403)	2.24329412
38	Single umbilical artery (HP:0001195)	2.24329412
39	Abnormality of the fetal cardiovascular system (HP:0010948)	2.24329412
40	Dysostosis multiplex (HP:0000943)	2.23135825
41	Abnormality of the umbilical cord (HP:0010881)	2.21071921
42	Abnormality of the phalanges of the hallux (HP:0010057)	2.20327399
43	Vertebral compression fractures (HP:0002953)	2.17341403
44	Disproportionate tall stature (HP:0001519)	2.15852962
45	Obstructive sleep apnea (HP:0002870)	2.15728496
46	J-shaped sella turcica (HP:0002680)	2.13269679
47	Cerebral inclusion bodies (HP:0100314)	2.13143494
48	Slender long bone (HP:0003100)	2.11912763
49	Upper limb amyotrophy (HP:0009129)	2.11121083
50	Distal upper limb amyotrophy (HP:0007149)	2.11121083
51	Supranuclear gaze palsy (HP:0000605)	2.10812669
52	Abnormality of the Achilles tendon (HP:0005109)	2.09998673
53	Long palpebral fissure (HP:0000637)	2.07842107
54	Turricephaly (HP:0000262)	2.07120232
55	Cholecystitis (HP:0001082)	2.02461806
56	Abnormal gallbladder physiology (HP:0012438)	2.02461806
57	Atelectasis (HP:0100750)	2.00964483
58	Bulbar palsy (HP:0001283)	1.98395026
59	Genu recurvatum (HP:0002816)	1.98319607
60	Unilateral renal agenesis (HP:0000122)	1.97331769
61	Breast hypoplasia (HP:0003187)	1.97145208
62	Anomalous pulmonary venous return (HP:0010772)	1.93849605
63	Thoracic kyphosis (HP:0002942)	1.93829363
64	Spinal cord compression (HP:0002176)	1.92781156
65	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.92233663
66	Trismus (HP:0000211)	1.91267031
67	Hypoparathyroidism (HP:0000829)	1.88651353
68	Congenital glaucoma (HP:0001087)	1.88360220
69	Abnormal number of erythroid precursors (HP:0012131)	1.87588476
70	Annular pancreas (HP:0001734)	1.87441497
71	Ocular albinism (HP:0001107)	1.86186185
72	Depression (HP:0000716)	1.85096062
73	Premature rupture of membranes (HP:0001788)	1.84858889
74	Neuronal loss in central nervous system (HP:0002529)	1.84801497
75	Cerebral aneurysm (HP:0004944)	1.82461030
76	Concave nail (HP:0001598)	1.82074800
77	Generalized amyotrophy (HP:0003700)	1.80391495
78	Enlarged penis (HP:0000040)	1.79860464
79	Protrusio acetabuli (HP:0003179)	1.79815641
80	Back pain (HP:0003418)	1.77576120
81	Hallux valgus (HP:0001822)	1.77506047
82	Deviation of the hallux (HP:0010051)	1.77357576
83	Abnormality of glycolipid metabolism (HP:0010969)	1.75069186
84	Abnormality of liposaccharide metabolism (HP:0010968)	1.75069186
85	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.75069186
86	Buphthalmos (HP:0000557)	1.74896786
87	Partial duplication of the phalanx of hand (HP:0009999)	1.73000750
88	Partial duplication of thumb phalanx (HP:0009944)	1.72545070
89	Abdominal distention (HP:0003270)	1.69773875
90	Hypoplastic heart (HP:0001961)	1.69486921
91	Hand muscle atrophy (HP:0009130)	1.69390119
92	Overriding aorta (HP:0002623)	1.68879159
93	Diminished motivation (HP:0000745)	1.68217424
94	Abnormality of the pulmonary veins (HP:0011718)	1.68117772
95	Duplication of thumb phalanx (HP:0009942)	1.68004901
96	Periauricular skin pits (HP:0100277)	1.67480532
97	Preauricular pit (HP:0004467)	1.67480532
98	Neurofibrillary tangles (HP:0002185)	1.67415444
99	Biconcave vertebral bodies (HP:0004586)	1.66649042
100	Pointed chin (HP:0000307)	1.65351097

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	5.30659996
2	SMG1	4.14648320
3	NME2	3.86231704
4	PRKD3	3.21055287
5	ICK	2.81096210
6	SIK1	2.70953824
7	IRAK3	2.44075024
8	PRPF4B	2.38176275
9	EEF2K	2.24098044
10	VRK2	2.21509932
11	PKN2	2.19816089
12	TAOK2	2.11222175
13	ARAF	2.09197479
14	MAP3K11	1.75466672
15	MAP3K9	1.62880866
16	TAOK1	1.57731547
17	BRAF	1.44576793
18	CDK12	1.42774621
19	RPS6KB2	1.41134337
20	TESK1	1.28671955
21	MAP2K2	1.28475575
22	BRSK1	1.27958614
23	TESK2	1.25409606
24	RPS6KA2	1.22036000
25	KSR2	1.16850103
26	ILK	1.16400616
27	MAP2K3	1.15900225
28	PRKD2	1.15884993
29	CDK7	1.13201328
30	MAP3K1	1.08189492
31	AURKA	1.07436500
32	IRAK2	1.06314151
33	EPHA2	1.02676774
34	TAF1	0.98090750
35	RPS6KC1	0.96882740
36	RPS6KL1	0.96882740
37	MTOR	0.96288987
38	PAK4	0.91363867
39	TYRO3	0.90245453
40	CHEK2	0.89943730
41	TNK2	0.88465710
42	LATS2	0.86439042
43	BUB1	0.86084906
44	DMPK	0.84052612
45	MAP3K3	0.83061282
46	CAMK1D	0.80680175
47	MAP3K10	0.80183096
48	PIM2	0.79819606
49	MAP3K8	0.76315435
50	RIPK1	0.75805077
51	MARK2	0.75255551
52	LMTK2	0.74705780
53	LRRK2	0.73626226
54	PDPK1	0.73464757
55	RPS6KA6	0.73412190
56	DAPK1	0.70144409
57	CDK4	0.68675998
58	PTK2	0.68548800
59	STK16	0.68285135
60	CAMKK1	0.67972500
61	EPHA4	0.66424477
62	ABL2	0.66291045
63	NTRK1	0.65525766
64	CAMK1G	0.64748752
65	MAP3K13	0.64040128
66	SCYL2	0.63778837
67	ERN1	0.62180624
68	MUSK	0.59938483
69	HIPK2	0.59828591
70	PAK6	0.58039743
71	AKT2	0.56906754
72	NME1	0.56321122
73	PAK1	0.56059186
74	CDK11A	0.55303319
75	PTK6	0.54927151
76	KDR	0.54817178
77	LIMK1	0.53649023
78	RPS6KA1	0.53292457
79	CDK15	0.51804052
80	STK4	0.49865867
81	BMX	0.49292976
82	ALK	0.48843352
83	PAK2	0.47243365
84	CAMK2G	0.46750052
85	DAPK3	0.45826843
86	STK38	0.45646469
87	PRKCI	0.44700706
88	CSNK1G3	0.43568308
89	MINK1	0.42909943
90	CDK18	0.42629518
91	CDK14	0.39616998
92	PRKCH	0.39096176
93	MAP3K2	0.38028161
94	PRKG2	0.37404012
95	MAPKAPK3	0.36744272
96	DDR2	0.36548745
97	MAP2K1	0.35582888
98	CHEK1	0.35569726
99	CDC7	0.35477663
100	GRK6	0.35395262

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.08918154
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.84707533
3	Other glycan degradation_Homo sapiens_hsa00511	2.68535790
4	Sulfur relay system_Homo sapiens_hsa04122	2.51369591
5	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.42795377
6	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.00451826
7	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.99170568
8	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.89448293
9	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.76221792
10	Vibrio cholerae infection_Homo sapiens_hsa05110	1.73583606
11	Bladder cancer_Homo sapiens_hsa05219	1.69487459
12	Base excision repair_Homo sapiens_hsa03410	1.69068104
13	Pentose phosphate pathway_Homo sapiens_hsa00030	1.68133148
14	Folate biosynthesis_Homo sapiens_hsa00790	1.64202983
15	Notch signaling pathway_Homo sapiens_hsa04330	1.61398051
16	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.59443706
17	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.58352497
18	DNA replication_Homo sapiens_hsa03030	1.56065944
19	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.50592288
20	Galactose metabolism_Homo sapiens_hsa00052	1.49757129
21	Prion diseases_Homo sapiens_hsa05020	1.48561033
22	Non-small cell lung cancer_Homo sapiens_hsa05223	1.44760997
23	Lysosome_Homo sapiens_hsa04142	1.41930601
24	Glioma_Homo sapiens_hsa05214	1.37400287
25	VEGF signaling pathway_Homo sapiens_hsa04370	1.35747749
26	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.33439670
27	mTOR signaling pathway_Homo sapiens_hsa04150	1.31796163
28	Acute myeloid leukemia_Homo sapiens_hsa05221	1.28781812
29	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.22669324
30	Endometrial cancer_Homo sapiens_hsa05213	1.20772995
31	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.19219335
32	Thyroid cancer_Homo sapiens_hsa05216	1.17346210
33	Insulin signaling pathway_Homo sapiens_hsa04910	1.12510794
34	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.10310207
35	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.10120651
36	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.07511100
37	ErbB signaling pathway_Homo sapiens_hsa04012	1.07391041
38	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.03792608
39	Melanoma_Homo sapiens_hsa05218	1.03432484
40	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99877882
41	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.97411328
42	Pancreatic cancer_Homo sapiens_hsa05212	0.94770438
43	Fatty acid elongation_Homo sapiens_hsa00062	0.91390716
44	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.89695324
45	Melanogenesis_Homo sapiens_hsa04916	0.89377523
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.85870473
47	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.85742905
48	AMPK signaling pathway_Homo sapiens_hsa04152	0.83422323
49	Long-term potentiation_Homo sapiens_hsa04720	0.81336193
50	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.80306897
51	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.79940908
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79741474
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77566659
54	Carbon metabolism_Homo sapiens_hsa01200	0.77244847
55	Renal cell carcinoma_Homo sapiens_hsa05211	0.76054860
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75324289
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.74019448
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72926129
59	GnRH signaling pathway_Homo sapiens_hsa04912	0.71456500
60	Estrogen signaling pathway_Homo sapiens_hsa04915	0.67870942
61	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.66668589
62	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66196551
63	Cell cycle_Homo sapiens_hsa04110	0.65628528
64	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.64787889
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.64368349
66	Prostate cancer_Homo sapiens_hsa05215	0.62717213
67	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.62280376
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.61453414
69	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.60060691
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59300248
71	Spliceosome_Homo sapiens_hsa03040	0.58266843
72	Glutathione metabolism_Homo sapiens_hsa00480	0.56794952
73	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.56623660
74	Cocaine addiction_Homo sapiens_hsa05030	0.55616822
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.54654219
76	Colorectal cancer_Homo sapiens_hsa05210	0.53529753
77	Lysine degradation_Homo sapiens_hsa00310	0.52401715
78	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.51957119
79	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50849086
80	Cholinergic synapse_Homo sapiens_hsa04725	0.50755382
81	Mismatch repair_Homo sapiens_hsa03430	0.49944550
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.49633922
83	Endocytosis_Homo sapiens_hsa04144	0.49064511
84	Wnt signaling pathway_Homo sapiens_hsa04310	0.48814507
85	Gap junction_Homo sapiens_hsa04540	0.48252978
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.48247212
87	Choline metabolism in cancer_Homo sapiens_hsa05231	0.45727331
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.45585270
89	RNA transport_Homo sapiens_hsa03013	0.45551030
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.45497087
91	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.44936511
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.44230050
93	MicroRNAs in cancer_Homo sapiens_hsa05206	0.40306591
94	MAPK signaling pathway_Homo sapiens_hsa04010	0.39548134
95	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38486651
96	Huntingtons disease_Homo sapiens_hsa05016	0.37083896
97	Axon guidance_Homo sapiens_hsa04360	0.36368862
98	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35626950
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.34982823
100	Rap1 signaling pathway_Homo sapiens_hsa04015	0.34608020

FNDC10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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