FNDC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.59021927
2sperm motility (GO:0030317)9.37693992
3cilium or flagellum-dependent cell motility (GO:0001539)8.79401871
4chromosome condensation (GO:0030261)7.93101064
5fusion of sperm to egg plasma membrane (GO:0007342)7.89054588
6sperm capacitation (GO:0048240)7.83255749
7spermatid nucleus differentiation (GO:0007289)7.34890149
8DNA packaging (GO:0006323)7.28558131
9single strand break repair (GO:0000012)7.22217481
10microtubule depolymerization (GO:0007019)6.97796674
11motile cilium assembly (GO:0044458)6.87832288
12spermatid development (GO:0007286)6.62784328
13epithelial cilium movement (GO:0003351)6.61965141
14rRNA methylation (GO:0031167)6.58084133
15cilium movement (GO:0003341)6.48164738
16response to pheromone (GO:0019236)6.24872861
17sexual reproduction (GO:0019953)6.23345513
18sperm-egg recognition (GO:0035036)5.94387696
19regulation of cilium movement (GO:0003352)5.93419584
20plasma membrane fusion (GO:0045026)5.88071254
21negative regulation of inclusion body assembly (GO:0090084)5.73336605
22multicellular organism reproduction (GO:0032504)5.70620310
23microtubule nucleation (GO:0007020)5.64112450
24reproduction (GO:0000003)5.63686978
25protein polyglutamylation (GO:0018095)5.53372797
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.49315481
27microtubule polymerization or depolymerization (GO:0031109)5.42004969
28microtubule severing (GO:0051013)5.40248493
29binding of sperm to zona pellucida (GO:0007339)5.35058840
30rRNA modification (GO:0000154)5.28845502
31calcium ion-dependent exocytosis (GO:0017156)5.17865453
32cell-cell recognition (GO:0009988)4.94085679
33phosphatidylethanolamine biosynthetic process (GO:0006646)4.90872989
34spermatogenesis (GO:0007283)4.81197060
35male gamete generation (GO:0048232)4.78994327
36phosphatidylethanolamine metabolic process (GO:0046337)4.55727597
37single fertilization (GO:0007338)4.50308302
38organic cation transport (GO:0015695)4.44891249
39axoneme assembly (GO:0035082)4.43329338
40gamete generation (GO:0007276)4.41154050
41polyamine biosynthetic process (GO:0006596)4.40815952
42homocysteine metabolic process (GO:0050667)4.40467677
43positive regulation of endothelial cell differentiation (GO:0045603)4.31234759
44centriole assembly (GO:0098534)4.22526477
45centriole replication (GO:0007099)4.17508081
46regulation of transcription involved in cell fate commitment (GO:0060850)4.14014262
47protein targeting to Golgi (GO:0000042)4.11614696
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.06576285
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.06576285
50regulation of microtubule-based movement (GO:0060632)4.05110151
51cellular ketone body metabolic process (GO:0046950)4.03596702
52regulation of plasminogen activation (GO:0010755)4.03069019
53microtubule bundle formation (GO:0001578)4.01622280
54sulfur amino acid catabolic process (GO:0000098)4.00268069
55establishment of protein localization to Golgi (GO:0072600)3.97619016
56positive regulation of Rab GTPase activity (GO:0032851)3.90494444
57regulation of Rab GTPase activity (GO:0032313)3.90494444
58growth hormone secretion (GO:0030252)3.89104266
59regulation of inclusion body assembly (GO:0090083)3.82172370
60chromatin silencing (GO:0006342)3.81782205
61retrograde transport, vesicle recycling within Golgi (GO:0000301)3.75761935
62inner ear receptor cell development (GO:0060119)3.74784481
63negative regulation of catenin import into nucleus (GO:0035414)3.60159033
64ketone body metabolic process (GO:1902224)3.50530950
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47914393
66multicellular organismal reproductive process (GO:0048609)3.45888130
67germ cell development (GO:0007281)3.45590749
68negative regulation of Ras GTPase activity (GO:0034261)3.42245510
69cellular process involved in reproduction in multicellular organism (GO:0022412)3.36266991
70fertilization (GO:0009566)3.33784362
71white fat cell differentiation (GO:0050872)3.24343338
72cysteine metabolic process (GO:0006534)3.24105134
73cochlea development (GO:0090102)3.18382322
74RNA destabilization (GO:0050779)3.15523301
75cranial nerve morphogenesis (GO:0021602)3.14255444
76left/right pattern formation (GO:0060972)3.12203093
77peptidyl-proline hydroxylation (GO:0019511)3.06907670
78behavioral response to nicotine (GO:0035095)3.05362256
79cerebral cortex neuron differentiation (GO:0021895)3.04182958
80regulation of endothelial cell differentiation (GO:0045601)3.03462369
81epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.02842844
82nucleosome disassembly (GO:0006337)3.01954767
83protein-DNA complex disassembly (GO:0032986)3.01954767
84protein localization to Golgi apparatus (GO:0034067)2.99368294
85regulation of interleukin-13 production (GO:0032656)2.97193733
86cellular response to pH (GO:0071467)2.93843517
87cilium organization (GO:0044782)2.91267725
88cilium assembly (GO:0042384)2.90753556
89negative regulation of Rho protein signal transduction (GO:0035024)2.89711624
90nucleus organization (GO:0006997)2.89010074
91negative regulation of gene expression, epigenetic (GO:0045814)2.88752732
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.87404098
93cellular biogenic amine biosynthetic process (GO:0042401)2.87194438
94acrosome assembly (GO:0001675)2.85178043
95membrane protein intracellular domain proteolysis (GO:0031293)2.84318222
96receptor recycling (GO:0001881)2.79064841
97primary amino compound metabolic process (GO:1901160)2.79064508
98intraciliary transport (GO:0042073)2.77395072
99ventricular system development (GO:0021591)2.75592645
100axonemal dynein complex assembly (GO:0070286)10.6210365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.03274762
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.33155462
3EZH2_22144423_ChIP-Seq_EOC_Human3.29124655
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.83043211
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.69927931
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.53775910
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38650416
8CTCF_27219007_Chip-Seq_Bcells_Human2.30336735
9DROSHA_22980978_ChIP-Seq_HELA_Human2.23523959
10P68_20966046_ChIP-Seq_HELA_Human2.23226329
11LXR_22292898_ChIP-Seq_THP-1_Human2.12593519
12YY1_22570637_ChIP-Seq_MALME-3M_Human1.99693738
13RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.94021109
14ELF1_20517297_ChIP-Seq_JURKAT_Human1.91120516
15SMC4_20622854_ChIP-Seq_HELA_Human1.85935184
16SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.85610452
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84220628
18BCL6_27268052_Chip-Seq_Bcells_Human1.79390898
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76249724
20PHF8_20622854_ChIP-Seq_HELA_Human1.74390930
21BCOR_27268052_Chip-Seq_Bcells_Human1.72804309
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71927729
23E2F1_20622854_ChIP-Seq_HELA_Human1.71834534
24CTCF_20526341_ChIP-Seq_ESCs_Human1.65629076
25EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64035661
26P300_27268052_Chip-Seq_Bcells_Human1.60500550
27TAF2_19829295_ChIP-Seq_ESCs_Human1.60041107
28TP63_22573176_ChIP-Seq_HFKS_Human1.59792970
29NANOG_20526341_ChIP-Seq_ESCs_Human1.58215085
30ERA_21632823_ChIP-Seq_H3396_Human1.58208079
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.55104629
32SOX2_22085726_ChIP-Seq_NPCs_Mouse1.50981438
33EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.50669404
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50499305
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50499305
36WDR5_24793694_ChIP-Seq_LNCAP_Human1.48306865
37OCT4_20526341_ChIP-Seq_ESCs_Human1.34522386
38RAC3_21632823_ChIP-Seq_H3396_Human1.33298080
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30918938
40TDRD3_21172665_ChIP-Seq_MCF-7_Human1.30114190
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29989440
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29832309
43MYC_19829295_ChIP-Seq_ESCs_Human1.29553796
44REST_21632747_ChIP-Seq_MESCs_Mouse1.28355136
45P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.28278453
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27670166
47CBP_20019798_ChIP-Seq_JUKART_Human1.27670166
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26688172
49MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.26627440
50SA1_27219007_Chip-Seq_Bcells_Human1.22262638
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21293654
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20532335
53VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19512537
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17876686
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.15624127
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15328086
57CEBPB_22108803_ChIP-Seq_LS180_Human1.14813736
58SOX11_22085726_ChIP-Seq_ESNs_Mouse1.14706010
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.14592791
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.11168946
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.10477717
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10279427
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.10263683
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09910801
65STAT1_20625510_ChIP-Seq_HELA_Human1.08192272
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07036876
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05544593
68OCT4_19829295_ChIP-Seq_ESCs_Human1.05225642
69NCOR_22424771_ChIP-Seq_293T_Human1.04810471
70GATA3_21867929_ChIP-Seq_CD8_Mouse1.03106296
71FOXH1_21741376_ChIP-Seq_ESCs_Human1.03085792
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02958684
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02958684
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01668772
75RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01157741
76OCT1_27270436_Chip-Seq_PROSTATE_Human1.00829058
77SOX2_21211035_ChIP-Seq_LN229_Human0.99469986
78TP53_20018659_ChIP-ChIP_R1E_Mouse0.98473815
79SMAD4_21741376_ChIP-Seq_EPCs_Human0.98224065
80P53_21459846_ChIP-Seq_SAOS-2_Human0.97658082
81RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97310168
82GATA3_21878914_ChIP-Seq_MCF-7_Human0.96641960
83ERG_20517297_ChIP-Seq_VCAP_Human0.95676510
84TET1_21451524_ChIP-Seq_MESCs_Mouse0.95676066
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95044789
86SMRT_27268052_Chip-Seq_Bcells_Human0.94767509
87EED_16625203_ChIP-ChIP_MESCs_Mouse0.94466260
88SMAD3_21741376_ChIP-Seq_ESCs_Human0.93868355
89SMAD4_21741376_ChIP-Seq_ESCs_Human0.93839124
90HNFA_21074721_ChIP-Seq_CACO-2_Human0.93455247
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93447616
92BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.92420496
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92238175
94TP53_22127205_ChIP-Seq_IMR90_Human0.92072237
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91725512
96RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91437451
97CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91418180
98RBPJ_21746931_ChIP-Seq_IB4_Human0.91406284
99RUNX2_22187159_ChIP-Seq_PCA_Human0.91013775
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.89997178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.59081800
2MP0005670_abnormal_white_adipose5.18476363
3MP0005377_hearing/vestibular/ear_phenot3.99070474
4MP0003878_abnormal_ear_physiology3.99070474
5MP0003698_abnormal_male_reproductive3.38596002
6MP0001929_abnormal_gametogenesis2.78875448
7MP0001348_abnormal_lacrimal_gland2.76327663
8MP0002132_abnormal_respiratory_system2.59533725
9MP0000678_abnormal_parathyroid_gland2.48532234
10MP0002653_abnormal_ependyma_morphology2.34082148
11MP0008995_early_reproductive_senescence2.28882897
12MP0003011_delayed_dark_adaptation2.17595510
13MP0003183_abnormal_peptide_metabolism2.15486774
14MP0001968_abnormal_touch/_nociception1.96215998
15MP0002161_abnormal_fertility/fecundity1.95027542
16MP0008789_abnormal_olfactory_epithelium1.89759075
17MP0000566_synostosis1.85286526
18MP0005423_abnormal_somatic_nervous1.83955379
19MP0002138_abnormal_hepatobiliary_system1.81520838
20MP0002736_abnormal_nociception_after1.76039287
21MP0002234_abnormal_pharynx_morphology1.75820817
22MP0000534_abnormal_ureter_morphology1.71308095
23MP0005394_taste/olfaction_phenotype1.63533835
24MP0005499_abnormal_olfactory_system1.63533835
25MP0002822_catalepsy1.62033686
26MP0003705_abnormal_hypodermis_morpholog1.61195613
27MP0005646_abnormal_pituitary_gland1.60448808
28MP0002249_abnormal_larynx_morphology1.56619938
29MP0000026_abnormal_inner_ear1.55848594
30MP0002210_abnormal_sex_determination1.52756432
31MP0005360_urolithiasis1.51326880
32MP0002282_abnormal_trachea_morphology1.49352488
33MP0004885_abnormal_endolymph1.48659984
34MP0002735_abnormal_chemical_nociception1.39441381
35MP0003787_abnormal_imprinting1.38560971
36MP0001486_abnormal_startle_reflex1.36176163
37MP0005367_renal/urinary_system_phenotyp1.31163060
38MP0000516_abnormal_urinary_system1.31163060
39MP0009053_abnormal_anal_canal1.30511658
40MP0000955_abnormal_spinal_cord1.29934380
41MP0006292_abnormal_olfactory_placode1.28905603
42MP0001145_abnormal_male_reproductive1.27367126
43MP0005551_abnormal_eye_electrophysiolog1.26784790
44MP0001963_abnormal_hearing_physiology1.23020525
45MP0000013_abnormal_adipose_tissue1.22971072
46MP0001485_abnormal_pinna_reflex1.22085454
47MP0000653_abnormal_sex_gland1.20699157
48MP0003942_abnormal_urinary_system1.14177661
49MP0004133_heterotaxia1.11963663
50MP0000003_abnormal_adipose_tissue1.10565430
51MP0005379_endocrine/exocrine_gland_phen1.08141429
52MP0001440_abnormal_grooming_behavior1.07575108
53MP0002229_neurodegeneration1.06971282
54MP0004742_abnormal_vestibular_system1.03963453
55MP0001270_distended_abdomen1.02903802
56MP0003880_abnormal_central_pattern1.01504892
57MP0002160_abnormal_reproductive_system0.98827205
58MP0000778_abnormal_nervous_system0.97671869
59MP0005253_abnormal_eye_physiology0.97155029
60MP0000049_abnormal_middle_ear0.94247057
61MP0002928_abnormal_bile_duct0.93735292
62MP0001765_abnormal_ion_homeostasis0.92418907
63MP0002067_abnormal_sensory_capabilities0.91200295
64MP0005623_abnormal_meninges_morphology0.87964682
65MP0001502_abnormal_circadian_rhythm0.87277255
66MP0002184_abnormal_innervation0.85696188
67MP0002572_abnormal_emotion/affect_behav0.84747240
68MP0002734_abnormal_mechanical_nocicepti0.82694102
69MP0006276_abnormal_autonomic_nervous0.82210559
70MP0002557_abnormal_social/conspecific_i0.81742645
71MP0001905_abnormal_dopamine_level0.80847452
72MP0002938_white_spotting0.79617691
73MP0002752_abnormal_somatic_nervous0.79397881
74MP0005167_abnormal_blood-brain_barrier0.75866236
75MP0002882_abnormal_neuron_morphology0.75657492
76MP0003718_maternal_effect0.75367307
77MP0004859_abnormal_synaptic_plasticity0.74064951
78MP0002733_abnormal_thermal_nociception0.73118105
79MP0003136_yellow_coat_color0.72071871
80MP0000681_abnormal_thyroid_gland0.69571314
81MP0003646_muscle_fatigue0.68578147
82MP0005310_abnormal_salivary_gland0.67816136
83MP0001984_abnormal_olfaction0.66508770
84MP0009115_abnormal_fat_cell0.65567870
85MP0003879_abnormal_hair_cell0.65221572
86MP0002069_abnormal_eating/drinking_beha0.65072867
87MP0003123_paternal_imprinting0.65070213
88MP0000631_abnormal_neuroendocrine_gland0.64472100
89MP0008875_abnormal_xenobiotic_pharmacok0.64047531
90MP0009745_abnormal_behavioral_response0.63105568
91MP0005195_abnormal_posterior_eye0.62116401
92MP0005391_vision/eye_phenotype0.61566016
93MP0001944_abnormal_pancreas_morphology0.61156466
94MP0004043_abnormal_pH_regulation0.60603452
95MP0002063_abnormal_learning/memory/cond0.60351700
96MP0002127_abnormal_cardiovascular_syste0.60252469
97MP0004019_abnormal_vitamin_homeostasis0.60115326
98MP0001970_abnormal_pain_threshold0.58884361
99MP0003861_abnormal_nervous_system0.58132904
100MP0001340_abnormal_eyelid_morphology0.57704123

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)7.94499639
2Abnormal respiratory epithelium morphology (HP:0012253)7.94499639
3Absent/shortened dynein arms (HP:0200106)7.57755424
4Dynein arm defect of respiratory motile cilia (HP:0012255)7.57755424
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.29585639
6Abnormal respiratory motile cilium physiology (HP:0012261)6.89549468
7Abnormal ciliary motility (HP:0012262)6.74912971
8Rhinitis (HP:0012384)5.42053874
9Nasal polyposis (HP:0100582)4.89477477
10Severe visual impairment (HP:0001141)4.75958473
11Chronic hepatic failure (HP:0100626)4.67994317
12Infertility (HP:0000789)4.32012564
13Tubulointerstitial nephritis (HP:0001970)4.20496754
14Chronic bronchitis (HP:0004469)4.05427198
15Abnormality of the nasal mucosa (HP:0000433)3.86289128
16Bronchiectasis (HP:0002110)3.81050343
17Attenuation of retinal blood vessels (HP:0007843)3.73402330
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.60160711
19Abnormality of alanine metabolism (HP:0010916)3.60160711
20Hyperalaninemia (HP:0003348)3.60160711
21Congenital sensorineural hearing impairment (HP:0008527)3.52339945
22Male infertility (HP:0003251)3.45597433
23Esophageal varix (HP:0002040)3.22904562
24Recurrent sinusitis (HP:0011108)3.20660334
25Bony spicule pigmentary retinopathy (HP:0007737)3.11182097
26Cone-rod dystrophy (HP:0000548)3.09370065
27Chronic sinusitis (HP:0011109)2.96632431
28Constricted visual fields (HP:0001133)2.83045054
29Hypoalphalipoproteinemia (HP:0003233)2.77708547
30Bell-shaped thorax (HP:0001591)2.75703931
31Hyperkalemia (HP:0002153)2.61492924
32Nephronophthisis (HP:0000090)2.57409408
33Progressive cerebellar ataxia (HP:0002073)2.51359485
34Abnormal rod and cone electroretinograms (HP:0008323)2.46236370
35Occipital encephalocele (HP:0002085)2.42650493
36Spontaneous hematomas (HP:0007420)2.39945819
37Abnormality of the aortic arch (HP:0012303)2.39544744
38Chronic otitis media (HP:0000389)2.38382091
39Abnormality of macular pigmentation (HP:0008002)2.35254641
40Portal hypertension (HP:0001409)2.35208073
41Atelectasis (HP:0100750)2.34274986
42Action tremor (HP:0002345)2.32081468
43Pancreatic fibrosis (HP:0100732)2.29739247
44Facial shape deformation (HP:0011334)2.21684939
45Potter facies (HP:0002009)2.21684939
46Chorioretinal atrophy (HP:0000533)2.20753088
47Tubulointerstitial abnormality (HP:0001969)2.20044740
48Pendular nystagmus (HP:0012043)2.18293646
49Abnormality of the renal medulla (HP:0100957)2.14042755
50Abnormality of the hepatic vasculature (HP:0006707)2.14029395
51Maternal diabetes (HP:0009800)2.13508675
52Epiphyseal dysplasia (HP:0002656)2.08560059
53Recurrent otitis media (HP:0000403)2.02943815
54Anencephaly (HP:0002323)2.02830148
55Asymmetric septal hypertrophy (HP:0001670)2.02598854
56Insulin-resistant diabetes mellitus (HP:0000831)2.02592840
57Hyperuricemia (HP:0002149)2.01084249
58Increased purine levels (HP:0004368)2.01084249
59Generalized aminoaciduria (HP:0002909)1.99527329
60Bronchitis (HP:0012387)1.99401533
61White forelock (HP:0002211)1.96962928
62Renal dysplasia (HP:0000110)1.95069913
63Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94071524
64Stage 5 chronic kidney disease (HP:0003774)1.89096436
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86789725
66Abnormal urine output (HP:0012590)1.80894629
67Abnormality of the parathyroid morphology (HP:0011766)1.80677192
68Median cleft lip (HP:0000161)1.77592021
69Impulsivity (HP:0100710)1.77475731
70Focal segmental glomerulosclerosis (HP:0000097)1.76548869
71Hyponatremia (HP:0002902)1.76385104
72Aplasia/Hypoplasia of the earlobes (HP:0009906)1.71552098
73Abnormality of homocysteine metabolism (HP:0010919)1.70732004
74Homocystinuria (HP:0002156)1.70732004
75Resting tremor (HP:0002322)1.70721719
76Hypoparathyroidism (HP:0000829)1.70665163
77Abnormality of midbrain morphology (HP:0002418)1.68555060
78Molar tooth sign on MRI (HP:0002419)1.68555060
79True hermaphroditism (HP:0010459)1.68218075
80Aplasia/Hypoplasia of the sacrum (HP:0008517)1.63916680
81Myokymia (HP:0002411)1.63781094
82Myocardial infarction (HP:0001658)1.63107495
83Cystic liver disease (HP:0006706)1.61256542
84Abnormality of renal excretion (HP:0011036)1.60671651
85Pigmentary retinal degeneration (HP:0001146)1.60046697
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59317308
87Absent epiphyses (HP:0010577)1.58363300
88Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.58363300
89Tubular atrophy (HP:0000092)1.57854932
90Hypoplasia of the thymus (HP:0000778)1.57459335
91Abnormality of sulfur amino acid metabolism (HP:0004339)1.56811155
92Postural instability (HP:0002172)1.56760464
93Postaxial foot polydactyly (HP:0001830)1.56167445
94Patchy hypopigmentation of hair (HP:0011365)1.55915807
95Hypoplastic left heart (HP:0004383)1.55751743
96Abnormal pancreas size (HP:0012094)1.55478259
97Short ribs (HP:0000773)1.54829787
98Widely patent fontanelles and sutures (HP:0004492)1.53319793
99Hypoplastic ischia (HP:0003175)1.52528679
100Muscle fiber atrophy (HP:0100295)1.52481800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.40369396
2PLK45.16296846
3TESK14.06359463
4MAP4K23.78447197
5DDR23.49423414
6INSRR2.63462590
7SGK4942.55200911
8SGK2232.55200911
9MAP3K112.51514995
10DYRK1B2.36513627
11MAP3K32.31966897
12MAP2K32.16218248
13PRKD32.16097811
14BRD42.00657986
15STK382.00015989
16SGK21.97173507
17NTRK31.74374611
18JAK31.63905441
19PNCK1.62832672
20PLK21.60582588
21MARK21.59841401
22NTRK21.53715368
23NEK61.51037923
24CDK91.48338626
25SGK31.45905813
26ACVR1B1.44231161
27EPHB21.42274478
28SIK21.41411549
29UHMK11.32724876
30DYRK31.26338391
31MAP3K41.21472854
32CAMK1G1.18101241
33DYRK21.16194041
34FGR1.15892360
35TYRO31.10552582
36STK38L1.06109613
37MST1R1.03429345
38WNK10.99675270
39PDPK10.89915588
40EPHA20.88022078
41MAP3K90.85180520
42CDK70.84969787
43PDK10.81616529
44RPS6KA20.80060537
45MARK10.78443971
46RPS6KA10.76411680
47BRAF0.75681746
48MINK10.75198225
49ICK0.72694964
50MAP4K10.69188835
51CDK190.67331704
52WNK40.66564870
53RPS6KB20.64380580
54CAMK10.64027108
55MTOR0.62762603
56SGK10.62554181
57PTK2B0.59274427
58CDK120.59071822
59MAP3K100.55747959
60MAP2K10.55308012
61MAP3K80.54746429
62LATS20.52609053
63RPS6KL10.52062987
64RPS6KC10.52062987
65AURKA0.51409771
66RPS6KA60.49785786
67MUSK0.49119068
68EPHA40.48333268
69PRKCQ0.47800175
70AKT30.47151429
71ARAF0.46898814
72PRKAA20.46424573
73MAP2K20.45747791
74CAMK40.45624852
75CAMK1D0.45097666
76MAP2K70.42396311
77ADRBK10.42026151
78MAPK80.41531285
79KSR20.39845403
80CDK50.39693197
81PRKCG0.39675422
82AKT10.37868119
83CSNK1A10.37800517
84RIPK40.36314862
85PRKCD0.35553958
86CDK20.32537075
87CCNB10.32181427
88LMTK20.31791485
89PRKG10.31146340
90PRKG20.30908183
91GSK3B0.29201521
92PRKCZ0.28674790
93STK110.24452435
94PINK10.23907557
95PRKAA10.23777989
96DYRK1A0.23718324
97CDK30.23500911
98MAP2K40.21864095
99MAPK10.21381769
100BLK0.20661087

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.89265823
2Fatty acid biosynthesis_Homo sapiens_hsa000614.80763140
3Olfactory transduction_Homo sapiens_hsa047402.84877525
4Arginine biosynthesis_Homo sapiens_hsa002202.64502614
5Phenylalanine metabolism_Homo sapiens_hsa003602.38358044
6Nicotine addiction_Homo sapiens_hsa050332.14624677
7Morphine addiction_Homo sapiens_hsa050322.08472544
8Collecting duct acid secretion_Homo sapiens_hsa049661.87473435
9Maturity onset diabetes of the young_Homo sapiens_hsa049501.86657944
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.83817796
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80931546
12GABAergic synapse_Homo sapiens_hsa047271.77977305
13Glycerophospholipid metabolism_Homo sapiens_hsa005641.76960788
14Taste transduction_Homo sapiens_hsa047421.64115524
15Synaptic vesicle cycle_Homo sapiens_hsa047211.51836960
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51733713
17Butanoate metabolism_Homo sapiens_hsa006501.48901668
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46673062
19Glutamatergic synapse_Homo sapiens_hsa047241.46208270
20Graft-versus-host disease_Homo sapiens_hsa053321.45892704
21Allograft rejection_Homo sapiens_hsa053301.40585268
22Autoimmune thyroid disease_Homo sapiens_hsa053201.38485316
23Type I diabetes mellitus_Homo sapiens_hsa049401.36696760
24Arginine and proline metabolism_Homo sapiens_hsa003301.34465308
25Circadian entrainment_Homo sapiens_hsa047131.31069670
26Retinol metabolism_Homo sapiens_hsa008301.30808127
27Serotonergic synapse_Homo sapiens_hsa047261.27632455
28Sulfur relay system_Homo sapiens_hsa041221.24651604
29Cholinergic synapse_Homo sapiens_hsa047251.23493896
30Hedgehog signaling pathway_Homo sapiens_hsa043401.20258460
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18677013
32Tyrosine metabolism_Homo sapiens_hsa003501.17141058
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14309646
34One carbon pool by folate_Homo sapiens_hsa006701.11996841
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09001439
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05875881
37Biosynthesis of amino acids_Homo sapiens_hsa012301.02068989
38Selenocompound metabolism_Homo sapiens_hsa004500.97673540
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95926304
40Regulation of autophagy_Homo sapiens_hsa041400.95460164
41Alcoholism_Homo sapiens_hsa050340.90599564
42Endocytosis_Homo sapiens_hsa041440.88650038
43Dopaminergic synapse_Homo sapiens_hsa047280.88410144
44Galactose metabolism_Homo sapiens_hsa000520.86975186
45Antigen processing and presentation_Homo sapiens_hsa046120.85356280
46Phototransduction_Homo sapiens_hsa047440.81979940
47Peroxisome_Homo sapiens_hsa041460.79388329
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79064099
49Huntingtons disease_Homo sapiens_hsa050160.78522563
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78156632
51mRNA surveillance pathway_Homo sapiens_hsa030150.77490144
52Fatty acid degradation_Homo sapiens_hsa000710.73998506
53Chemical carcinogenesis_Homo sapiens_hsa052040.71569185
54Viral myocarditis_Homo sapiens_hsa054160.70491397
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70488314
56cAMP signaling pathway_Homo sapiens_hsa040240.68265201
57ABC transporters_Homo sapiens_hsa020100.65283378
58Basal cell carcinoma_Homo sapiens_hsa052170.64776612
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64122475
60Notch signaling pathway_Homo sapiens_hsa043300.63184646
61Influenza A_Homo sapiens_hsa051640.62816278
62Type II diabetes mellitus_Homo sapiens_hsa049300.60170153
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59570864
64Cocaine addiction_Homo sapiens_hsa050300.59005907
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58428890
66Axon guidance_Homo sapiens_hsa043600.58175583
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57930798
68Salivary secretion_Homo sapiens_hsa049700.57477470
69VEGF signaling pathway_Homo sapiens_hsa043700.56522333
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56094363
71Fatty acid metabolism_Homo sapiens_hsa012120.55658993
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55305796
73PPAR signaling pathway_Homo sapiens_hsa033200.52170575
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50222162
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49479029
76Calcium signaling pathway_Homo sapiens_hsa040200.49260604
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47919327
78RNA transport_Homo sapiens_hsa030130.47112839
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45519924
80MAPK signaling pathway_Homo sapiens_hsa040100.44480919
81Linoleic acid metabolism_Homo sapiens_hsa005910.43411568
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42672107
83Histidine metabolism_Homo sapiens_hsa003400.41339793
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40044158
85Adherens junction_Homo sapiens_hsa045200.38091978
86B cell receptor signaling pathway_Homo sapiens_hsa046620.37585695
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33920738
88Hippo signaling pathway_Homo sapiens_hsa043900.33621488
89Chemokine signaling pathway_Homo sapiens_hsa040620.33578139
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31496730
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31394191
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.30626446
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30328745
94Insulin secretion_Homo sapiens_hsa049110.28925934
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28546648
96Phagosome_Homo sapiens_hsa041450.26065374
97Nitrogen metabolism_Homo sapiens_hsa009100.24909680
98Melanogenesis_Homo sapiens_hsa049160.24302749
99Inositol phosphate metabolism_Homo sapiens_hsa005620.24175807
100Vitamin digestion and absorption_Homo sapiens_hsa049770.23923795

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