

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.03900820 |
| 2 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.91055938 |
| 3 | synaptic vesicle maturation (GO:0016188) | 4.91012828 |
| 4 | locomotory exploration behavior (GO:0035641) | 4.89846549 |
| 5 | glutamate secretion (GO:0014047) | 4.82188289 |
| 6 | vocalization behavior (GO:0071625) | 4.75458871 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.58580910 |
| 8 | synaptic vesicle exocytosis (GO:0016079) | 4.57973511 |
| 9 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.55502482 |
| 10 | gamma-aminobutyric acid transport (GO:0015812) | 4.44709882 |
| 11 | neurotransmitter secretion (GO:0007269) | 4.25037252 |
| 12 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.22178006 |
| 13 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.20492764 |
| 14 | layer formation in cerebral cortex (GO:0021819) | 4.13125255 |
| 15 | protein localization to synapse (GO:0035418) | 4.08591536 |
| 16 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.98051718 |
| 17 | exploration behavior (GO:0035640) | 3.94313574 |
| 18 | neuron cell-cell adhesion (GO:0007158) | 3.92713632 |
| 19 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.92372869 |
| 20 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.86737639 |
| 21 | neuronal action potential propagation (GO:0019227) | 3.84723987 |
| 22 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.77800438 |
| 23 | low-density lipoprotein particle clearance (GO:0034383) | 3.76338938 |
| 24 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.75144642 |
| 25 | glutamate receptor signaling pathway (GO:0007215) | 3.72791186 |
| 26 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.66282209 |
| 27 | dendritic spine morphogenesis (GO:0060997) | 3.63442830 |
| 28 | cellular potassium ion homeostasis (GO:0030007) | 3.62086728 |
| 29 | synaptic transmission, glutamatergic (GO:0035249) | 3.56380212 |
| 30 | regulation of synaptic vesicle transport (GO:1902803) | 3.55443703 |
| 31 | cell communication by electrical coupling (GO:0010644) | 3.49375019 |
| 32 | response to pheromone (GO:0019236) | 3.49118386 |
| 33 | positive regulation of synapse maturation (GO:0090129) | 3.44700335 |
| 34 | neuron recognition (GO:0008038) | 3.44001428 |
| 35 | sodium ion export (GO:0071436) | 3.41478328 |
| 36 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.36956355 |
| 37 | neuron-neuron synaptic transmission (GO:0007270) | 3.31901892 |
| 38 | axonal fasciculation (GO:0007413) | 3.31567071 |
| 39 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.31023785 |
| 40 | neurotransmitter transport (GO:0006836) | 3.30796264 |
| 41 | regulation of synapse structural plasticity (GO:0051823) | 3.28972446 |
| 42 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.28078707 |
| 43 | long-term memory (GO:0007616) | 3.27648918 |
| 44 | regulation of neurotransmitter levels (GO:0001505) | 3.23181607 |
| 45 | proline transport (GO:0015824) | 3.19256456 |
| 46 | dendrite morphogenesis (GO:0048813) | 3.19235233 |
| 47 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.15921805 |
| 48 | alanine transport (GO:0032328) | 3.15662974 |
| 49 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.12969453 |
| 50 | nucleobase catabolic process (GO:0046113) | 3.12573819 |
| 51 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.11008823 |
| 52 | transmission of nerve impulse (GO:0019226) | 3.08378276 |
| 53 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.07296932 |
| 54 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.05850572 |
| 55 | postsynaptic membrane organization (GO:0001941) | 3.04215462 |
| 56 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.03418778 |
| 57 | neuronal ion channel clustering (GO:0045161) | 3.02213243 |
| 58 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.99727601 |
| 59 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.99360862 |
| 60 | neuromuscular process controlling posture (GO:0050884) | 2.97630927 |
| 61 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.97441399 |
| 62 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.96995621 |
| 63 | plasma lipoprotein particle clearance (GO:0034381) | 2.96694283 |
| 64 | cellular sodium ion homeostasis (GO:0006883) | 2.95767787 |
| 65 | regulation of synaptic plasticity (GO:0048167) | 2.95161668 |
| 66 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.94725314 |
| 67 | negative regulation of lipase activity (GO:0060192) | 2.94393729 |
| 68 | synaptic vesicle endocytosis (GO:0048488) | 2.94334676 |
| 69 | response to auditory stimulus (GO:0010996) | 2.94187668 |
| 70 | positive regulation of dendritic spine development (GO:0060999) | 2.93519390 |
| 71 | activation of protein kinase A activity (GO:0034199) | 2.93162604 |
| 72 | positive regulation of membrane potential (GO:0045838) | 2.93092579 |
| 73 | cell migration in hindbrain (GO:0021535) | 2.92004979 |
| 74 | neuromuscular process controlling balance (GO:0050885) | 2.91261570 |
| 75 | negative regulation of fibrinolysis (GO:0051918) | 2.89925024 |
| 76 | regulation of postsynaptic membrane potential (GO:0060078) | 2.89807405 |
| 77 | glutamate metabolic process (GO:0006536) | 2.86854820 |
| 78 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.86352121 |
| 79 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.84899916 |
| 80 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.83428958 |
| 81 | acylglycerol catabolic process (GO:0046464) | 2.78692293 |
| 82 | neutral lipid catabolic process (GO:0046461) | 2.78692293 |
| 83 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 2.78320790 |
| 84 | L-phenylalanine catabolic process (GO:0006559) | 2.78320790 |
| 85 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.78260922 |
| 86 | alpha-linolenic acid metabolic process (GO:0036109) | 2.77920352 |
| 87 | auditory behavior (GO:0031223) | 2.77488920 |
| 88 | long-term synaptic potentiation (GO:0060291) | 2.75399842 |
| 89 | glucocorticoid biosynthetic process (GO:0006704) | 2.74951215 |
| 90 | regulation of vesicle fusion (GO:0031338) | 2.74260452 |
| 91 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.72581557 |
| 92 | innervation (GO:0060384) | 2.72072137 |
| 93 | regulation of respiratory system process (GO:0044065) | 2.68665110 |
| 94 | triglyceride catabolic process (GO:0019433) | 2.68249540 |
| 95 | regulation of neurotransmitter secretion (GO:0046928) | 2.68126258 |
| 96 | cerebellar Purkinje cell layer development (GO:0021680) | 2.67590563 |
| 97 | L-serine transport (GO:0015825) | 2.66844074 |
| 98 | L-phenylalanine metabolic process (GO:0006558) | 2.66232261 |
| 99 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 2.66232261 |
| 100 | behavioral response to cocaine (GO:0048148) | 2.66149540 |
| 101 | behavioral defense response (GO:0002209) | 2.65868535 |
| 102 | behavioral fear response (GO:0001662) | 2.65868535 |
| 103 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.65736288 |
| 104 | regulation of dendritic spine development (GO:0060998) | 2.63833723 |
| 105 | potassium ion homeostasis (GO:0055075) | 2.63144476 |
| 106 | cerebellar granule cell differentiation (GO:0021707) | 2.62404039 |
| 107 | cellular ketone body metabolic process (GO:0046950) | 2.62379405 |
| 108 | C4-dicarboxylate transport (GO:0015740) | 2.58960202 |
| 109 | protein carboxylation (GO:0018214) | 2.58446163 |
| 110 | peptidyl-glutamic acid carboxylation (GO:0017187) | 2.58446163 |
| 111 | regulation of fibrinolysis (GO:0051917) | 2.58138365 |
| 112 | presynaptic membrane assembly (GO:0097105) | 2.57215881 |
| 113 | complement activation, alternative pathway (GO:0006957) | 2.57167994 |
| 114 | regulation of female receptivity (GO:0045924) | 2.57126205 |
| 115 | regulation of plasminogen activation (GO:0010755) | 2.56367959 |
| 116 | membrane depolarization during action potential (GO:0086010) | 2.56357437 |
| 117 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.55997849 |
| 118 | presynaptic membrane organization (GO:0097090) | 2.55521724 |
| 119 | amino acid import (GO:0043090) | 2.55294651 |
| 120 | response to dietary excess (GO:0002021) | 2.52896396 |
| 121 | diacylglycerol metabolic process (GO:0046339) | 2.52128233 |
| 122 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 2.50055572 |
| 123 | regulation of cholesterol esterification (GO:0010872) | 2.48540789 |
| 124 | acylglycerol homeostasis (GO:0055090) | 2.45979001 |
| 125 | triglyceride homeostasis (GO:0070328) | 2.45979001 |
| 126 | regulation of cholesterol biosynthetic process (GO:0045540) | 2.43728264 |
| 127 | L-amino acid import (GO:0043092) | 2.41205799 |
| 128 | glycerolipid catabolic process (GO:0046503) | 2.40635249 |
| 129 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 2.38465949 |
| 130 | negative regulation of catenin import into nucleus (GO:0035414) | 2.36507503 |
| 131 | dendritic spine organization (GO:0097061) | 2.36219703 |
| 132 | positive regulation of neurotransmitter transport (GO:0051590) | 2.32911391 |
| 133 | regulation of protein activation cascade (GO:2000257) | 2.32704914 |
| 134 | glucocorticoid metabolic process (GO:0008211) | 2.32149308 |
| 135 | mating behavior (GO:0007617) | 2.30780504 |
| 136 | regulation of cAMP-dependent protein kinase activity (GO:2000479) | 2.30657361 |
| 137 | potassium ion import (GO:0010107) | 2.27249179 |
| 138 | high-density lipoprotein particle remodeling (GO:0034375) | 2.25649645 |
| 139 | negative regulation of sterol transport (GO:0032372) | 2.24905286 |
| 140 | negative regulation of cholesterol transport (GO:0032375) | 2.24905286 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.76250511 |
| 2 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.07820206 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.06756730 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.05082613 |
| 5 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.99075857 |
| 6 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.95380775 |
| 7 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.82718375 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.81038785 |
| 9 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.81038785 |
| 10 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.78427499 |
| 11 | * SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.68408577 |
| 12 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.66433211 |
| 13 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.57001675 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.56629644 |
| 15 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.55908480 |
| 16 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.54426523 |
| 17 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.54110687 |
| 18 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.49903485 |
| 19 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.48866053 |
| 20 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.46238447 |
| 21 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.32898378 |
| 22 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.29555775 |
| 23 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.29105672 |
| 24 | * ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.24365776 |
| 25 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.22268778 |
| 26 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.19743066 |
| 27 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.14798256 |
| 28 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.09919357 |
| 29 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.06316753 |
| 30 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.05294743 |
| 31 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 2.01490489 |
| 32 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.94660021 |
| 33 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.91307889 |
| 34 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.83570343 |
| 35 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.81847161 |
| 36 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.74105516 |
| 37 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.64380156 |
| 38 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.55392968 |
| 39 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.55229596 |
| 40 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.50394761 |
| 41 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.49898414 |
| 42 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.48206593 |
| 43 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.46917391 |
| 44 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.45309802 |
| 45 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.42865101 |
| 46 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.40669960 |
| 47 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.40432491 |
| 48 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.35069580 |
| 49 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.32406349 |
| 50 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.30385727 |
| 51 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.29958034 |
| 52 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.29814206 |
| 53 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.28891677 |
| 54 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.26765335 |
| 55 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.26697054 |
| 56 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.25888065 |
| 57 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.25691016 |
| 58 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.21936451 |
| 59 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.20971221 |
| 60 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.19502442 |
| 61 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.18521867 |
| 62 | AR_19668381_ChIP-Seq_PC3_Human | 1.17037526 |
| 63 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.16186469 |
| 64 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.15953885 |
| 65 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.12880349 |
| 66 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.12030266 |
| 67 | P300_19829295_ChIP-Seq_ESCs_Human | 1.11734541 |
| 68 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.11639885 |
| 69 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.11356210 |
| 70 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.10665362 |
| 71 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.10448273 |
| 72 | AR_25329375_ChIP-Seq_VCAP_Human | 1.09893757 |
| 73 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.09788592 |
| 74 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.09596006 |
| 75 | KDM2B_26808549_Chip-Seq_K562_Human | 1.08102635 |
| 76 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.07112170 |
| 77 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.06790675 |
| 78 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.03257384 |
| 79 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.02264007 |
| 80 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.99652333 |
| 81 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.98926772 |
| 82 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.98906645 |
| 83 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.97384987 |
| 84 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.97291979 |
| 85 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.97097864 |
| 86 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.95576615 |
| 87 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.94846342 |
| 88 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.94157293 |
| 89 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.93072522 |
| 90 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.92485578 |
| 91 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.92068272 |
| 92 | STAT3_23295773_ChIP-Seq_U87_Human | 0.92029946 |
| 93 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.91244190 |
| 94 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.91001144 |
| 95 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.90801127 |
| 96 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.88146723 |
| 97 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.87392564 |
| 98 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.87351147 |
| 99 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.86357232 |
| 100 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.86348207 |
| 101 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.84354667 |
| 102 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.83762674 |
| 103 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.82561463 |
| 104 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.82394380 |
| 105 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.81971258 |
| 106 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.81483791 |
| 107 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.81369160 |
| 108 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.80975430 |
| 109 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.80880913 |
| 110 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.80830817 |
| 111 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.80720082 |
| 112 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.80720082 |
| 113 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.80290530 |
| 114 | * TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.80246233 |
| 115 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.79568553 |
| 116 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.79476742 |
| 117 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.79463224 |
| 118 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.79322298 |
| 119 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.78457774 |
| 120 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.78450425 |
| 121 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.77572174 |
| 122 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.77540051 |
| 123 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.75704669 |
| 124 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.74933033 |
| 125 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.74564873 |
| 126 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.74488453 |
| 127 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.74417493 |
| 128 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.73410430 |
| 129 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.72127969 |
| 130 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.69237163 |
| 131 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.68684219 |
| 132 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.68324056 |
| 133 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 0.68295574 |
| 134 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.68080478 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.82112728 |
| 2 | MP0003880_abnormal_central_pattern | 4.11452118 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.75512060 |
| 4 | MP0004270_analgesia | 3.20646290 |
| 5 | MP0002063_abnormal_learning/memory/cond | 3.02705020 |
| 6 | MP0009745_abnormal_behavioral_response | 3.02019986 |
| 7 | MP0002064_seizures | 2.79145088 |
| 8 | MP0002139_abnormal_hepatobiliary_system | 2.69094733 |
| 9 | MP0003329_amyloid_beta_deposits | 2.63131482 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.62659169 |
| 11 | MP0009046_muscle_twitch | 2.56894334 |
| 12 | MP0005423_abnormal_somatic_nervous | 2.52995512 |
| 13 | MP0002572_abnormal_emotion/affect_behav | 2.50792951 |
| 14 | MP0001486_abnormal_startle_reflex | 2.42226572 |
| 15 | MP0005360_urolithiasis | 2.41681977 |
| 16 | MP0005670_abnormal_white_adipose | 2.27377677 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 2.23818522 |
| 18 | MP0002272_abnormal_nervous_system | 2.16604090 |
| 19 | MP0002736_abnormal_nociception_after | 2.06539828 |
| 20 | MP0001440_abnormal_grooming_behavior | 2.05351279 |
| 21 | MP0004858_abnormal_nervous_system | 1.99237800 |
| 22 | MP0005085_abnormal_gallbladder_physiolo | 1.94526650 |
| 23 | MP0000778_abnormal_nervous_system | 1.94522137 |
| 24 | MP0006276_abnormal_autonomic_nervous | 1.86866330 |
| 25 | MP0001501_abnormal_sleep_pattern | 1.84138887 |
| 26 | MP0002733_abnormal_thermal_nociception | 1.82008157 |
| 27 | MP0002822_catalepsy | 1.79044541 |
| 28 | MP0005365_abnormal_bile_salt | 1.78241054 |
| 29 | MP0002735_abnormal_chemical_nociception | 1.78192516 |
| 30 | MP0002067_abnormal_sensory_capabilities | 1.78091447 |
| 31 | MP0002184_abnormal_innervation | 1.71303698 |
| 32 | MP0002557_abnormal_social/conspecific_i | 1.68951164 |
| 33 | MP0005646_abnormal_pituitary_gland | 1.68053752 |
| 34 | MP0009780_abnormal_chondrocyte_physiolo | 1.66021526 |
| 35 | MP0004885_abnormal_endolymph | 1.62208803 |
| 36 | MP0000955_abnormal_spinal_cord | 1.57390622 |
| 37 | MP0001970_abnormal_pain_threshold | 1.55394444 |
| 38 | MP0008875_abnormal_xenobiotic_pharmacok | 1.54778042 |
| 39 | MP0008569_lethality_at_weaning | 1.52851974 |
| 40 | MP0004272_abnormal_basement_membrane | 1.50959195 |
| 41 | MP0002909_abnormal_adrenal_gland | 1.49703374 |
| 42 | MP0000604_amyloidosis | 1.48260032 |
| 43 | MP0005386_behavior/neurological_phenoty | 1.46714204 |
| 44 | MP0004924_abnormal_behavior | 1.46714204 |
| 45 | MP0004811_abnormal_neuron_physiology | 1.45973577 |
| 46 | MP0001984_abnormal_olfaction | 1.42505786 |
| 47 | MP0005666_abnormal_adipose_tissue | 1.42023518 |
| 48 | MP0002971_abnormal_brown_adipose | 1.41321295 |
| 49 | MP0004142_abnormal_muscle_tone | 1.37530953 |
| 50 | MP0005623_abnormal_meninges_morphology | 1.37192135 |
| 51 | MP0003122_maternal_imprinting | 1.37137327 |
| 52 | MP0001502_abnormal_circadian_rhythm | 1.35998101 |
| 53 | MP0010329_abnormal_lipoprotein_level | 1.33780004 |
| 54 | MP0002882_abnormal_neuron_morphology | 1.32164175 |
| 55 | MP0002066_abnormal_motor_capabilities/c | 1.30889023 |
| 56 | MP0010368_abnormal_lymphatic_system | 1.29856145 |
| 57 | MP0008438_abnormal_cutaneous_collagen | 1.24654288 |
| 58 | MP0003633_abnormal_nervous_system | 1.24179521 |
| 59 | MP0003690_abnormal_glial_cell | 1.17805419 |
| 60 | MP0000566_synostosis | 1.17383499 |
| 61 | MP0002152_abnormal_brain_morphology | 1.11219523 |
| 62 | MP0003631_nervous_system_phenotype | 1.10472345 |
| 63 | MP0003705_abnormal_hypodermis_morpholog | 1.09235991 |
| 64 | MP0001529_abnormal_vocalization | 1.09132454 |
| 65 | MP0005083_abnormal_biliary_tract | 1.06970619 |
| 66 | MP0005551_abnormal_eye_electrophysiolog | 1.06652547 |
| 67 | MP0001299_abnormal_eye_distance/ | 1.06317619 |
| 68 | MP0005375_adipose_tissue_phenotype | 1.05969264 |
| 69 | MP0002249_abnormal_larynx_morphology | 1.05438541 |
| 70 | MP0003879_abnormal_hair_cell | 1.05424880 |
| 71 | MP0002876_abnormal_thyroid_physiology | 1.00737960 |
| 72 | MP0001905_abnormal_dopamine_level | 0.99583138 |
| 73 | MP0003632_abnormal_nervous_system | 0.96428136 |
| 74 | MP0005332_abnormal_amino_acid | 0.96200372 |
| 75 | MP0002069_abnormal_eating/drinking_beha | 0.96199758 |
| 76 | MP0003123_paternal_imprinting | 0.95143607 |
| 77 | MP0003252_abnormal_bile_duct | 0.95114291 |
| 78 | MP0010030_abnormal_orbit_morphology | 0.93698357 |
| 79 | MP0002638_abnormal_pupillary_reflex | 0.93074401 |
| 80 | MP0008872_abnormal_physiological_respon | 0.93030290 |
| 81 | MP0000920_abnormal_myelination | 0.92789707 |
| 82 | MP0005448_abnormal_energy_balance | 0.92170258 |
| 83 | MP0005595_abnormal_vascular_smooth | 0.91668223 |
| 84 | MP0002295_abnormal_pulmonary_circulatio | 0.90266104 |
| 85 | MP0001177_atelectasis | 0.89957646 |
| 86 | MP0000639_abnormal_adrenal_gland | 0.89181386 |
| 87 | MP0003283_abnormal_digestive_organ | 0.88117658 |
| 88 | MP0005187_abnormal_penis_morphology | 0.85438730 |
| 89 | MP0005535_abnormal_body_temperature | 0.83427168 |
| 90 | MP0009840_abnormal_foam_cell | 0.82769348 |
| 91 | MP0008874_decreased_physiological_sensi | 0.82557091 |
| 92 | MP0003279_aneurysm | 0.82365718 |
| 93 | MP0000534_abnormal_ureter_morphology | 0.82260156 |
| 94 | MP0003787_abnormal_imprinting | 0.82184447 |
| 95 | MP0003634_abnormal_glial_cell | 0.80987531 |
| 96 | MP0002229_neurodegeneration | 0.80068148 |
| 97 | MP0002090_abnormal_vision | 0.80042415 |
| 98 | MP0003075_altered_response_to | 0.79945813 |
| 99 | MP0005645_abnormal_hypothalamus_physiol | 0.78935400 |
| 100 | MP0004145_abnormal_muscle_electrophysio | 0.77962182 |
| 101 | MP0002752_abnormal_somatic_nervous | 0.76195409 |
| 102 | MP0000751_myopathy | 0.75639810 |
| 103 | MP0002837_dystrophic_cardiac_calcinosis | 0.75542334 |
| 104 | MP0003195_calcinosis | 0.74883771 |
| 105 | MP0003942_abnormal_urinary_system | 0.74276594 |
| 106 | MP0005334_abnormal_fat_pad | 0.73933421 |
| 107 | MP0005257_abnormal_intraocular_pressure | 0.73901647 |
| 108 | MP0003137_abnormal_impulse_conducting | 0.73085670 |
| 109 | MP0000003_abnormal_adipose_tissue | 0.70347119 |
| 110 | MP0003191_abnormal_cellular_cholesterol | 0.70156483 |
| 111 | MP0008004_abnormal_stomach_pH | 0.68775510 |
| 112 | MP0005410_abnormal_fertilization | 0.68081281 |
| 113 | MP0002118_abnormal_lipid_homeostasis | 0.68038112 |
| 114 | MP0001963_abnormal_hearing_physiology | 0.67660847 |
| 115 | MP0001666_abnormal_nutrient_absorption | 0.65488313 |
| 116 | MP0000049_abnormal_middle_ear | 0.65054093 |
| 117 | MP0003861_abnormal_nervous_system | 0.64929452 |
| 118 | MP0005508_abnormal_skeleton_morphology | 0.64924656 |
| 119 | MP0004085_abnormal_heartbeat | 0.64882317 |
| 120 | MP0000631_abnormal_neuroendocrine_gland | 0.63969803 |
| 121 | MP0008961_abnormal_basal_metabolism | 0.62498919 |
| 122 | MP0005394_taste/olfaction_phenotype | 0.62267674 |
| 123 | MP0005499_abnormal_olfactory_system | 0.62267674 |
| 124 | MP0003011_delayed_dark_adaptation | 0.61708679 |
| 125 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.58969350 |
| 126 | MP0002089_abnormal_postnatal_growth/wei | 0.58639190 |
| 127 | MP0003868_abnormal_feces_composition | 0.56961205 |
| 128 | MP0000026_abnormal_inner_ear | 0.55402268 |
| 129 | MP0002082_postnatal_lethality | 0.54400738 |
| 130 | MP0010770_preweaning_lethality | 0.54400738 |
| 131 | MP0005167_abnormal_blood-brain_barrier | 0.54217076 |
| 132 | MP0004130_abnormal_muscle_cell | 0.53715215 |
| 133 | MP0010769_abnormal_survival | 0.53426043 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.05986663 |
| 2 | Myokymia (HP:0002411) | 5.93255169 |
| 3 | Focal seizures (HP:0007359) | 4.60530731 |
| 4 | Visual hallucinations (HP:0002367) | 4.16495742 |
| 5 | Epileptic encephalopathy (HP:0200134) | 4.00495782 |
| 6 | Progressive cerebellar ataxia (HP:0002073) | 3.73632453 |
| 7 | Neurofibrillary tangles (HP:0002185) | 3.59417293 |
| 8 | Supranuclear gaze palsy (HP:0000605) | 3.51650602 |
| 9 | Megalencephaly (HP:0001355) | 3.51327915 |
| 10 | Cerebral inclusion bodies (HP:0100314) | 3.47271924 |
| 11 | Action tremor (HP:0002345) | 3.41694270 |
| 12 | Atonic seizures (HP:0010819) | 3.39969085 |
| 13 | Status epilepticus (HP:0002133) | 3.37835898 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 3.37397949 |
| 15 | Absence seizures (HP:0002121) | 3.35071560 |
| 16 | Febrile seizures (HP:0002373) | 3.29405607 |
| 17 | Hyperventilation (HP:0002883) | 3.28928180 |
| 18 | Deep venous thrombosis (HP:0002625) | 3.25921569 |
| 19 | Protrusio acetabuli (HP:0003179) | 3.17654939 |
| 20 | Abnormality of the lower motor neuron (HP:0002366) | 3.14779045 |
| 21 | Abnormality of complement system (HP:0005339) | 2.92619024 |
| 22 | Depression (HP:0000716) | 2.89908152 |
| 23 | Dysdiadochokinesis (HP:0002075) | 2.89472539 |
| 24 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.88934714 |
| 25 | Dialeptic seizures (HP:0011146) | 2.88879607 |
| 26 | Hemiparesis (HP:0001269) | 2.84904110 |
| 27 | Poor eye contact (HP:0000817) | 2.82862809 |
| 28 | Ankle clonus (HP:0011448) | 2.82348138 |
| 29 | Impaired social interactions (HP:0000735) | 2.74870310 |
| 30 | Abnormal social behavior (HP:0012433) | 2.74870310 |
| 31 | Hemiplegia (HP:0002301) | 2.71885941 |
| 32 | Abnormal eating behavior (HP:0100738) | 2.71818977 |
| 33 | Anxiety (HP:0000739) | 2.69776417 |
| 34 | Torticollis (HP:0000473) | 2.65848064 |
| 35 | Broad-based gait (HP:0002136) | 2.63954779 |
| 36 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 2.61289104 |
| 37 | Hypobetalipoproteinemia (HP:0003563) | 2.60979559 |
| 38 | Dysmetria (HP:0001310) | 2.59904107 |
| 39 | Epileptiform EEG discharges (HP:0011182) | 2.58876494 |
| 40 | Focal dystonia (HP:0004373) | 2.57981647 |
| 41 | Xanthomatosis (HP:0000991) | 2.55426366 |
| 42 | EEG with generalized epileptiform discharges (HP:0011198) | 2.54697027 |
| 43 | Mutism (HP:0002300) | 2.54515491 |
| 44 | Postural instability (HP:0002172) | 2.51995074 |
| 45 | Hyperlipoproteinemia (HP:0010980) | 2.51212564 |
| 46 | Limb dystonia (HP:0002451) | 2.50555659 |
| 47 | Intrahepatic cholestasis (HP:0001406) | 2.49140401 |
| 48 | Hypsarrhythmia (HP:0002521) | 2.48980785 |
| 49 | Drooling (HP:0002307) | 2.45626175 |
| 50 | Excessive salivation (HP:0003781) | 2.45626175 |
| 51 | Premature rupture of membranes (HP:0001788) | 2.45163887 |
| 52 | Truncal ataxia (HP:0002078) | 2.43191123 |
| 53 | Polyphagia (HP:0002591) | 2.43188145 |
| 54 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.39384312 |
| 55 | Craniofacial dystonia (HP:0012179) | 2.38924856 |
| 56 | Abnormality of binocular vision (HP:0011514) | 2.35554525 |
| 57 | Diplopia (HP:0000651) | 2.35554525 |
| 58 | Scanning speech (HP:0002168) | 2.35240218 |
| 59 | Amblyopia (HP:0000646) | 2.35064682 |
| 60 | Acanthosis nigricans (HP:0000956) | 2.29991173 |
| 61 | Spastic gait (HP:0002064) | 2.29318857 |
| 62 | Mitral stenosis (HP:0001718) | 2.28675178 |
| 63 | Gaze-evoked nystagmus (HP:0000640) | 2.28146072 |
| 64 | Bradykinesia (HP:0002067) | 2.23695973 |
| 65 | Shallow orbits (HP:0000586) | 2.21593973 |
| 66 | Intention tremor (HP:0002080) | 2.20682860 |
| 67 | Aplasia involving bones of the extremities (HP:0009825) | 2.20146306 |
| 68 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.20146306 |
| 69 | Aplasia of the phalanges of the hand (HP:0009802) | 2.20146306 |
| 70 | Prolonged partial thromboplastin time (HP:0003645) | 2.18670712 |
| 71 | Genetic anticipation (HP:0003743) | 2.17434506 |
| 72 | Coronal craniosynostosis (HP:0004440) | 2.17389824 |
| 73 | Agitation (HP:0000713) | 2.16257876 |
| 74 | Insomnia (HP:0100785) | 2.14491890 |
| 75 | Growth hormone excess (HP:0000845) | 2.13078654 |
| 76 | Urinary urgency (HP:0000012) | 2.12090629 |
| 77 | Hyperglycinemia (HP:0002154) | 2.09948481 |
| 78 | Ketosis (HP:0001946) | 2.09466581 |
| 79 | Split foot (HP:0001839) | 2.06822849 |
| 80 | Impaired vibratory sensation (HP:0002495) | 2.05312080 |
| 81 | Generalized myoclonic seizures (HP:0002123) | 2.05292228 |
| 82 | Delusions (HP:0000746) | 2.03079215 |
| 83 | Vascular tortuosity (HP:0004948) | 2.02938340 |
| 84 | Arterial tortuosity (HP:0005116) | 2.02506601 |
| 85 | Abnormality of the Achilles tendon (HP:0005109) | 2.00126928 |
| 86 | Hypercholesterolemia (HP:0003124) | 1.99494012 |
| 87 | Systemic lupus erythematosus (HP:0002725) | 1.99443297 |
| 88 | Delayed CNS myelination (HP:0002188) | 1.99212398 |
| 89 | Abnormality of dentin (HP:0010299) | 1.98089904 |
| 90 | Insidious onset (HP:0003587) | 1.97945469 |
| 91 | Termporal pattern (HP:0011008) | 1.97945469 |
| 92 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 1.97674064 |
| 93 | Confusion (HP:0001289) | 1.95659019 |
| 94 | Ulnar bowing (HP:0003031) | 1.94883040 |
| 95 | Sleep apnea (HP:0010535) | 1.94274159 |
| 96 | Pheochromocytoma (HP:0002666) | 1.94048785 |
| 97 | Impaired smooth pursuit (HP:0007772) | 1.93541047 |
| 98 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.92085851 |
| 99 | Hypoalphalipoproteinemia (HP:0003233) | 1.91705385 |
| 100 | Stereotypic behavior (HP:0000733) | 1.90475707 |
| 101 | Neonatal short-limb short stature (HP:0008921) | 1.89887878 |
| 102 | Amyotrophic lateral sclerosis (HP:0007354) | 1.89369800 |
| 103 | Hypolipoproteinemia (HP:0010981) | 1.89056609 |
| 104 | Lower limb muscle weakness (HP:0007340) | 1.87467615 |
| 105 | Neonatal onset (HP:0003623) | 1.87047150 |
| 106 | Upper limb amyotrophy (HP:0009129) | 1.85708326 |
| 107 | Distal upper limb amyotrophy (HP:0007149) | 1.85708326 |
| 108 | Obstructive sleep apnea (HP:0002870) | 1.85602372 |
| 109 | Tetraplegia (HP:0002445) | 1.83526752 |
| 110 | Complement deficiency (HP:0004431) | 1.83116286 |
| 111 | Abnormality of the corticospinal tract (HP:0002492) | 1.82857895 |
| 112 | Broad metatarsal (HP:0001783) | 1.82371037 |
| 113 | Glomerulonephritis (HP:0000099) | 1.81891663 |
| 114 | Epidermoid cyst (HP:0200040) | 1.81868566 |
| 115 | Clonus (HP:0002169) | 1.81233427 |
| 116 | Neuronal loss in central nervous system (HP:0002529) | 1.79386532 |
| 117 | Psychosis (HP:0000709) | 1.79323209 |
| 118 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.77577793 |
| 119 | Ketoacidosis (HP:0001993) | 1.76521874 |
| 120 | Progressive inability to walk (HP:0002505) | 1.75929316 |
| 121 | Achilles tendon contracture (HP:0001771) | 1.74206060 |
| 122 | Turricephaly (HP:0000262) | 1.74064974 |
| 123 | Buphthalmos (HP:0000557) | 1.73998072 |
| 124 | Hand muscle atrophy (HP:0009130) | 1.73241135 |
| 125 | Hypoventilation (HP:0002791) | 1.73201040 |
| 126 | Rigidity (HP:0002063) | 1.71089148 |
| 127 | Bronchomalacia (HP:0002780) | 1.71010695 |
| 128 | Spinal rigidity (HP:0003306) | 1.67552922 |
| 129 | Atrophic scars (HP:0001075) | 1.61257865 |
| 130 | Skin nodule (HP:0200036) | 1.60454031 |
| 131 | Retinal atrophy (HP:0001105) | 1.59625375 |
| 132 | Akinesia (HP:0002304) | 1.56948367 |
| 133 | Abnormality of carpal bone ossification (HP:0006257) | 1.56743484 |
| 134 | Spontaneous abortion (HP:0005268) | 1.55996831 |
| 135 | Mixed hearing impairment (HP:0000410) | 1.55520891 |
| 136 | Insulin resistance (HP:0000855) | 1.54556650 |
| 137 | Hemorrhage of the eye (HP:0011885) | 1.52314074 |
| 138 | Ectopia lentis (HP:0001083) | 1.51696454 |
| 139 | Joint hemorrhage (HP:0005261) | 1.51572081 |
| 140 | Lymphangioma (HP:0100764) | 1.51477952 |
| 141 | Oligomenorrhea (HP:0000876) | 1.51184613 |
| 142 | Precocious puberty (HP:0000826) | 1.50889242 |
| 143 | Short nail (HP:0001799) | 1.50694866 |
| 144 | Hyperextensible skin (HP:0000974) | 1.50120109 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.43737902 |
| 2 | NTRK3 | 4.24540360 |
| 3 | MARK1 | 3.55304353 |
| 4 | MAP3K9 | 3.30396866 |
| 5 | MAP3K4 | 3.02940883 |
| 6 | MINK1 | 2.95910355 |
| 7 | NTRK2 | 2.54915311 |
| 8 | MAP2K7 | 2.42360366 |
| 9 | MAP2K4 | 2.42308350 |
| 10 | DAPK2 | 2.41607825 |
| 11 | PAK6 | 2.18268945 |
| 12 | KSR1 | 1.96557673 |
| 13 | TESK1 | 1.86994046 |
| 14 | KSR2 | 1.83947114 |
| 15 | NTRK1 | 1.81079718 |
| 16 | PRKD3 | 1.80798736 |
| 17 | CAMKK1 | 1.73151457 |
| 18 | CDK19 | 1.72549693 |
| 19 | PHKG2 | 1.57058519 |
| 20 | PHKG1 | 1.57058519 |
| 21 | MAPK13 | 1.54519822 |
| 22 | LATS2 | 1.54206212 |
| 23 | PDGFRA | 1.47100797 |
| 24 | CDK5 | 1.43903758 |
| 25 | SIK2 | 1.42271993 |
| 26 | PRKCG | 1.41215531 |
| 27 | LMTK2 | 1.41100199 |
| 28 | CASK | 1.38925521 |
| 29 | TNIK | 1.36685300 |
| 30 | MAP3K12 | 1.31358002 |
| 31 | STK38 | 1.29822367 |
| 32 | PLK2 | 1.24139825 |
| 33 | UHMK1 | 1.22512621 |
| 34 | DAPK1 | 1.19967778 |
| 35 | TYRO3 | 1.18258082 |
| 36 | RIPK4 | 1.18194850 |
| 37 | INSRR | 1.17691868 |
| 38 | GRK5 | 1.14884680 |
| 39 | PNCK | 1.14676478 |
| 40 | PTK2 | 1.06906629 |
| 41 | DYRK2 | 0.98497866 |
| 42 | CDK18 | 0.98045267 |
| 43 | MOS | 0.97931672 |
| 44 | CDK15 | 0.96769416 |
| 45 | CAMK1D | 0.94853259 |
| 46 | ARAF | 0.93930415 |
| 47 | TIE1 | 0.93047012 |
| 48 | CDK14 | 0.92949560 |
| 49 | FES | 0.91056803 |
| 50 | PAK3 | 0.90750758 |
| 51 | CAMK2A | 0.89816231 |
| 52 | SGK223 | 0.88698221 |
| 53 | SGK494 | 0.88698221 |
| 54 | DYRK1A | 0.88219194 |
| 55 | CDK11A | 0.87665165 |
| 56 | LIMK1 | 0.82504196 |
| 57 | PRPF4B | 0.82456308 |
| 58 | RET | 0.81185684 |
| 59 | ABL2 | 0.81099541 |
| 60 | CSNK1G2 | 0.79382245 |
| 61 | BRAF | 0.77411442 |
| 62 | PRKCZ | 0.74828537 |
| 63 | PINK1 | 0.73888801 |
| 64 | SIK1 | 0.73054309 |
| 65 | TAOK2 | 0.70950662 |
| 66 | FGFR2 | 0.70486389 |
| 67 | ROCK1 | 0.69529452 |
| 68 | STK16 | 0.68801541 |
| 69 | DYRK1B | 0.68127058 |
| 70 | EPHB2 | 0.68080549 |
| 71 | SGK2 | 0.67691937 |
| 72 | CAMK2B | 0.67613099 |
| 73 | PDK1 | 0.67074209 |
| 74 | TRIB3 | 0.66382794 |
| 75 | STK11 | 0.66290609 |
| 76 | FER | 0.66285125 |
| 77 | PKN1 | 0.65508256 |
| 78 | CAMK1 | 0.64765522 |
| 79 | MAP3K2 | 0.64162260 |
| 80 | MAP3K11 | 0.63894935 |
| 81 | ICK | 0.63532800 |
| 82 | CAMK1G | 0.63021561 |
| 83 | CAMK2G | 0.62330555 |
| 84 | MAP3K13 | 0.61376153 |
| 85 | NEK1 | 0.59864354 |
| 86 | TAOK1 | 0.59198849 |
| 87 | MAPK12 | 0.59049043 |
| 88 | CAMKK2 | 0.57086991 |
| 89 | SGK3 | 0.56075922 |
| 90 | RAF1 | 0.55931934 |
| 91 | PAK2 | 0.55806888 |
| 92 | PRKCH | 0.55801880 |
| 93 | PTK2B | 0.53323481 |
| 94 | MAP3K7 | 0.52464569 |
| 95 | MAP2K1 | 0.52217498 |
| 96 | SGK1 | 0.51725375 |
| 97 | MAP3K6 | 0.50515382 |
| 98 | ERBB2 | 0.49989530 |
| 99 | MET | 0.49627573 |
| 100 | MAPK4 | 0.48909318 |
| 101 | FGFR4 | 0.48586333 |
| 102 | AKT3 | 0.47608417 |
| 103 | RPS6KA3 | 0.46801283 |
| 104 | PRKAA1 | 0.46623106 |
| 105 | WNK3 | 0.45848372 |
| 106 | RIPK1 | 0.45175787 |
| 107 | EPHA3 | 0.45089299 |
| 108 | PRKG2 | 0.44920731 |
| 109 | SIK3 | 0.43630168 |
| 110 | ERBB4 | 0.43585418 |
| 111 | FGR | 0.43123463 |
| 112 | DDR2 | 0.42198784 |
| 113 | PRKCE | 0.41671139 |
| 114 | NME1 | 0.40878086 |
| 115 | DAPK3 | 0.40834051 |
| 116 | ROCK2 | 0.39977850 |
| 117 | PDGFRB | 0.39967396 |
| 118 | CAMK4 | 0.39855402 |
| 119 | ADRBK1 | 0.39762756 |
| 120 | PDPK1 | 0.39147164 |
| 121 | FYN | 0.38901217 |
| 122 | MARK2 | 0.38357325 |
| 123 | CDC42BPA | 0.37918758 |
| 124 | ALK | 0.36063438 |
| 125 | MAPK10 | 0.34609498 |
| 126 | CAMK2D | 0.34491970 |
| 127 | MAP3K10 | 0.34256720 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.71120248 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 3.19938724 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.51701674 |
| 4 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.39837536 |
| 5 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.38264719 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.31109587 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.11944013 |
| 8 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.11445397 |
| 9 | Circadian entrainment_Homo sapiens_hsa04713 | 2.06714099 |
| 10 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.05159298 |
| 11 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.03408412 |
| 12 | Long-term potentiation_Homo sapiens_hsa04720 | 1.95309975 |
| 13 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.94211886 |
| 14 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.87669202 |
| 15 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.82694410 |
| 16 | Olfactory transduction_Homo sapiens_hsa04740 | 1.80550382 |
| 17 | Morphine addiction_Homo sapiens_hsa05032 | 1.78884320 |
| 18 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.74266205 |
| 19 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.69984026 |
| 20 | Salivary secretion_Homo sapiens_hsa04970 | 1.60604602 |
| 21 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.59294755 |
| 22 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.58071348 |
| 23 | Insulin secretion_Homo sapiens_hsa04911 | 1.55269129 |
| 24 | Bile secretion_Homo sapiens_hsa04976 | 1.52673246 |
| 25 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.51738000 |
| 26 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.42877361 |
| 27 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.33300065 |
| 28 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.32332894 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.30498118 |
| 30 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.25482996 |
| 31 | Taste transduction_Homo sapiens_hsa04742 | 1.23765420 |
| 32 | Long-term depression_Homo sapiens_hsa04730 | 1.21558922 |
| 33 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.20483757 |
| 34 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.19678055 |
| 35 | Cocaine addiction_Homo sapiens_hsa05030 | 1.19056750 |
| 36 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.14614167 |
| 37 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.14204255 |
| 38 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.13179750 |
| 39 | Renin secretion_Homo sapiens_hsa04924 | 1.11118076 |
| 40 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.09470751 |
| 41 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.08982015 |
| 42 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.06825818 |
| 43 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.06582439 |
| 44 | Gap junction_Homo sapiens_hsa04540 | 1.05944781 |
| 45 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.04863816 |
| 46 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.04528790 |
| 47 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.02449834 |
| 48 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.01179455 |
| 49 | Histidine metabolism_Homo sapiens_hsa00340 | 1.00230822 |
| 50 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.00082211 |
| 51 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.98298821 |
| 52 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.97959329 |
| 53 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.97096422 |
| 54 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.95381234 |
| 55 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.94745592 |
| 56 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.93956547 |
| 57 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.92324303 |
| 58 | Axon guidance_Homo sapiens_hsa04360 | 0.92049054 |
| 59 | Melanogenesis_Homo sapiens_hsa04916 | 0.91045626 |
| 60 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.86051211 |
| 61 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.84896977 |
| 62 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.83737569 |
| 63 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.81731426 |
| 64 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.81564409 |
| 65 | Sulfur relay system_Homo sapiens_hsa04122 | 0.78680481 |
| 66 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.77786574 |
| 67 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.77737340 |
| 68 | Glioma_Homo sapiens_hsa05214 | 0.75686716 |
| 69 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.74444001 |
| 70 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.73749149 |
| 71 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.67946342 |
| 72 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.67651085 |
| 73 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.66095485 |
| 74 | Prion diseases_Homo sapiens_hsa05020 | 0.65326337 |
| 75 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.64393916 |
| 76 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.64351064 |
| 77 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.64137242 |
| 78 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.62907519 |
| 79 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.61680094 |
| 80 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.61524857 |
| 81 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.61199834 |
| 82 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.60596256 |
| 83 | Peroxisome_Homo sapiens_hsa04146 | 0.56603682 |
| 84 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.56249816 |
| 85 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.55741829 |
| 86 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.54024043 |
| 87 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.53468530 |
| 88 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.53449653 |
| 89 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.53325051 |
| 90 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.52996116 |
| 91 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.52912243 |
| 92 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.52317893 |
| 93 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.51886036 |
| 94 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.51562802 |
| 95 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.50033110 |
| 96 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.49001012 |
| 97 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.48539855 |
| 98 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.48237732 |
| 99 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.47738759 |
| 100 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.46513386 |
| 101 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.45668066 |
| 102 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.43974104 |
| 103 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.43893502 |
| 104 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.43795823 |
| 105 | Carbon metabolism_Homo sapiens_hsa01200 | 0.42648099 |
| 106 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.42400016 |
| 107 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.42192975 |
| 108 | Focal adhesion_Homo sapiens_hsa04510 | 0.41885015 |
| 109 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.40506222 |
| 110 | Phototransduction_Homo sapiens_hsa04744 | 0.40445480 |
| 111 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.39075712 |
| 112 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.38057232 |
| 113 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.37845969 |
| 114 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.37438504 |
| 115 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.34953437 |
| 116 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.32241012 |
| 117 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.31860388 |
| 118 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.31809105 |
| 119 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.31242284 |
| 120 | Circadian rhythm_Homo sapiens_hsa04710 | 0.30619839 |
| 121 | Retinol metabolism_Homo sapiens_hsa00830 | 0.29751605 |

