FNDC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.55540846
2motile cilium assembly (GO:0044458)9.49624187
3multicellular organism reproduction (GO:0032504)9.46279837
4binding of sperm to zona pellucida (GO:0007339)9.26635234
5cell-cell recognition (GO:0009988)9.24170356
6plasma membrane fusion (GO:0045026)9.07058100
7spermatid development (GO:0007286)9.04284451
8epithelial cilium movement (GO:0003351)8.97357013
9axonemal dynein complex assembly (GO:0070286)8.93447348
10rRNA methylation (GO:0031167)8.49983130
11reproduction (GO:0000003)8.24649563
12regulation of cilium movement (GO:0003352)8.16709058
13cilium or flagellum-dependent cell motility (GO:0001539)7.72391209
14negative regulation of inclusion body assembly (GO:0090084)7.54814198
15cilium movement (GO:0003341)7.37085328
16rRNA modification (GO:0000154)7.18669140
17phosphatidylethanolamine biosynthetic process (GO:0006646)6.86878160
18sperm capacitation (GO:0048240)6.71243324
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.67969647
20single fertilization (GO:0007338)6.64339827
21protein targeting to Golgi (GO:0000042)6.62322538
22microtubule depolymerization (GO:0007019)6.46145158
23phosphatidylethanolamine metabolic process (GO:0046337)6.41913592
24establishment of protein localization to Golgi (GO:0072600)6.38377629
25spermatogenesis (GO:0007283)6.34774930
26male gamete generation (GO:0048232)6.31992187
27retrograde transport, vesicle recycling within Golgi (GO:0000301)6.18384176
28calcium ion-dependent exocytosis (GO:0017156)6.18134014
29organic cation transport (GO:0015695)6.12172262
30centriole replication (GO:0007099)6.08464207
31piRNA metabolic process (GO:0034587)6.06417354
32regulation of inclusion body assembly (GO:0090083)6.06147098
33male meiosis (GO:0007140)6.04131677
34synaptonemal complex organization (GO:0070193)6.02799664
35gamete generation (GO:0007276)5.79513955
36synaptonemal complex assembly (GO:0007130)5.78679217
37fertilization (GO:0009566)5.62728009
38centriole assembly (GO:0098534)5.47750059
39ventricular system development (GO:0021591)5.23441701
40cellular ketone body metabolic process (GO:0046950)5.03552811
41protein localization to Golgi apparatus (GO:0034067)5.03110411
42positive regulation of Rab GTPase activity (GO:0032851)4.99670427
43regulation of Rab GTPase activity (GO:0032313)4.99670427
44cell recognition (GO:0008037)4.99364346
45germ cell development (GO:0007281)4.95516538
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.89796504
47regulation of microtubule-based movement (GO:0060632)4.88826184
48regulation of centriole replication (GO:0046599)4.87101646
49spermatid nucleus differentiation (GO:0007289)4.83886131
50chromosome condensation (GO:0030261)4.77580540
51microtubule severing (GO:0051013)4.70530454
52multicellular organismal reproductive process (GO:0048609)4.57487995
53DNA packaging (GO:0006323)4.50506374
54regulation of transcription involved in cell fate commitment (GO:0060850)4.43759775
55ketone body metabolic process (GO:1902224)4.42247405
56left/right pattern formation (GO:0060972)4.27283327
57glycerol ether metabolic process (GO:0006662)4.22646432
58male meiosis I (GO:0007141)4.05062717
59sexual reproduction (GO:0019953)3.98943604
60ether metabolic process (GO:0018904)3.93126262
61multicellular organismal movement (GO:0050879)3.90283491
62musculoskeletal movement (GO:0050881)3.90283491
63protein polyglutamylation (GO:0018095)3.82221752
64seminiferous tubule development (GO:0072520)3.82117181
65DNA methylation involved in gamete generation (GO:0043046)3.76626665
66protein localization to cilium (GO:0061512)3.73896074
67multicellular organismal development (GO:0007275)3.69654608
68chromosome organization involved in meiosis (GO:0070192)3.61850852
69nucleosome disassembly (GO:0006337)3.59577010
70protein-DNA complex disassembly (GO:0032986)3.59577010
71single strand break repair (GO:0000012)3.57105615
72negative regulation of Rho protein signal transduction (GO:0035024)3.54436984
73microtubule nucleation (GO:0007020)3.47994232
74RNA destabilization (GO:0050779)3.44861520
75microtubule polymerization or depolymerization (GO:0031109)3.42455761
76chaperone-mediated protein complex assembly (GO:0051131)3.40129280
77DNA conformation change (GO:0071103)3.37194492
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.36441767
79meiotic nuclear division (GO:0007126)3.34117066
80cerebral cortex neuron differentiation (GO:0021895)3.23896812
81cranial nerve morphogenesis (GO:0021602)3.22801472
82meiosis I (GO:0007127)3.19285546
83coenzyme catabolic process (GO:0009109)3.19145526
84cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.16950999
85negative regulation of gene expression, epigenetic (GO:0045814)3.15178039
86mitotic G1 DNA damage checkpoint (GO:0031571)3.14569083
87membrane depolarization during action potential (GO:0086010)3.13511302
88homeostasis of number of cells within a tissue (GO:0048873)3.11123636
89calcium ion import (GO:0070509)3.09177140
90glycolytic process (GO:0006096)3.06192171
91axoneme assembly (GO:0035082)3.04857056
92regulation of somitogenesis (GO:0014807)3.02914632
93positive regulation of guanylate cyclase activity (GO:0031284)3.01234240
94regulation of interleukin-13 production (GO:0032656)2.99915668
95polyol catabolic process (GO:0046174)2.94527445
96NAD biosynthetic process (GO:0009435)2.92138560
97membrane protein intracellular domain proteolysis (GO:0031293)2.91922623
98mitochondrial fission (GO:0000266)2.89854595
99protein K11-linked deubiquitination (GO:0035871)2.89260183
100cilium morphogenesis (GO:0060271)2.88987030
101RNA methylation (GO:0001510)2.88419809
102regulation of spindle checkpoint (GO:0090231)2.87843179
103glomerular visceral epithelial cell development (GO:0072015)2.87714755
104G1 DNA damage checkpoint (GO:0044783)2.86349255
105regulation of guanylate cyclase activity (GO:0031282)2.86345706
106microtubule-based movement (GO:0007018)2.84687263
107negative regulation of histone methylation (GO:0031061)2.83497749
108cellular response to pH (GO:0071467)2.83224602
109histone H3-K9 demethylation (GO:0033169)2.81605053
110Golgi to endosome transport (GO:0006895)2.80130112
111histone exchange (GO:0043486)2.78759573
112cilium organization (GO:0044782)2.78593570
113carnitine transport (GO:0015879)2.76154585
114amino-acid betaine transport (GO:0015838)2.76154585
115cellular component assembly involved in morphogenesis (GO:0010927)2.73300387
116genitalia morphogenesis (GO:0035112)2.73255042
117RNA localization (GO:0006403)2.72798164
118cilium assembly (GO:0042384)2.72441735
119mitotic sister chromatid cohesion (GO:0007064)2.71165616
120protein refolding (GO:0042026)2.70419838
121regulation of protein kinase A signaling (GO:0010738)2.67394115
122positive regulation of macrophage activation (GO:0043032)2.64320368
123meiotic cell cycle (GO:0051321)2.61044332
124carnitine transmembrane transport (GO:1902603)2.60313440
125nucleus organization (GO:0006997)2.60179745
126regulation of cilium assembly (GO:1902017)2.56735944
127protein depolymerization (GO:0051261)2.56419951
128negative regulation of organelle assembly (GO:1902116)2.56370186
129nucleoside diphosphate phosphorylation (GO:0006165)2.54343969
130peptidyl-glutamic acid modification (GO:0018200)2.51696134
131interferon-gamma secretion (GO:0072643)2.51650675
132response to acidic pH (GO:0010447)2.51201076
133intraciliary transport (GO:0042073)2.50542770
134sequestering of actin monomers (GO:0042989)2.48995505
135mitochondrion degradation (GO:0000422)2.43260450
136polyamine biosynthetic process (GO:0006596)2.42047420
137alditol metabolic process (GO:0019400)2.40334976
138regulation of protein kinase C signaling (GO:0090036)2.34885054
139chromatin silencing (GO:0006342)2.33487855
140peptidyl-threonine dephosphorylation (GO:0035970)2.29261161
141sperm motility (GO:0030317)13.2275058
142acrosome reaction (GO:0007340)12.1248954
143cell wall macromolecule catabolic process (GO:0016998)12.0681002
144cell wall macromolecule metabolic process (GO:0044036)12.0681002
145fusion of sperm to egg plasma membrane (GO:0007342)11.7241627
146sperm-egg recognition (GO:0035036)10.2973297
147acrosome assembly (GO:0001675)10.1610855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.24170427
2EZH2_22144423_ChIP-Seq_EOC_Human5.41341216
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.43440328
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.33858961
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.36215205
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59374712
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.52683853
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.38433405
9VDR_22108803_ChIP-Seq_LS180_Human2.36573639
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.29810049
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25213585
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23188156
13ERA_21632823_ChIP-Seq_H3396_Human2.18243279
14ZNF274_21170338_ChIP-Seq_K562_Hela2.14060704
15RAC3_21632823_ChIP-Seq_H3396_Human2.12458312
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10515821
17REST_21632747_ChIP-Seq_MESCs_Mouse2.09240540
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human2.06889275
19BCL6_27268052_Chip-Seq_Bcells_Human2.03369468
20EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.02485341
21P68_20966046_ChIP-Seq_HELA_Human1.99737720
22NANOG_20526341_ChIP-Seq_ESCs_Human1.96392839
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92410556
24E2F1_20622854_ChIP-Seq_HELA_Human1.92367759
25EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.88325480
26PHF8_20622854_ChIP-Seq_HELA_Human1.87898813
27SMC4_20622854_ChIP-Seq_HELA_Human1.87253811
28BCOR_27268052_Chip-Seq_Bcells_Human1.82869735
29GATA1_26923725_Chip-Seq_HPCs_Mouse1.80239132
30TAF2_19829295_ChIP-Seq_ESCs_Human1.80032665
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78338629
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.78325698
33LXR_22292898_ChIP-Seq_THP-1_Human1.75712080
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.73806777
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73094502
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.72791303
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71893746
38TAF15_26573619_Chip-Seq_HEK293_Human1.70953115
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.68790248
40KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66023096
41MYC_19829295_ChIP-Seq_ESCs_Human1.65471311
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64478168
43CTCF_20526341_ChIP-Seq_ESCs_Human1.63914666
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.62307560
45EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61685576
46OCT4_20526341_ChIP-Seq_ESCs_Human1.61409518
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.61248512
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.60440593
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58044545
50* TP63_22573176_ChIP-Seq_HFKS_Human1.56677331
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.56078022
52ERG_20517297_ChIP-Seq_VCAP_Human1.54751929
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.53571306
54P300_27268052_Chip-Seq_Bcells_Human1.50942076
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50809794
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48589400
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47688097
58KDM2B_26808549_Chip-Seq_REH_Human1.47313603
59ER_23166858_ChIP-Seq_MCF-7_Human1.45515467
60STAT1_17558387_ChIP-Seq_HELA_Human1.41563420
61P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.41235383
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40251716
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40116327
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39400520
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39265389
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.38449431
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.38403041
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.36951994
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35268577
70HNFA_21074721_ChIP-Seq_CACO-2_Human1.34679576
71SA1_27219007_Chip-Seq_Bcells_Human1.34143667
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.34080677
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34020645
74CBP_20019798_ChIP-Seq_JUKART_Human1.34020645
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33577822
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.33214960
77CEBPB_22108803_ChIP-Seq_LS180_Human1.32661315
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32411842
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31717947
80RBPJ_21746931_ChIP-Seq_IB4_Human1.30999147
81AR_25329375_ChIP-Seq_VCAP_Human1.27905987
82FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27727118
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.27311981
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.27154164
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26274607
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26274607
87ETV1_20927104_ChIP-Seq_GIST48_Human1.24667780
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24036254
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.23365921
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23312829
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22455565
92GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.22428745
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21707172
94TP53_18474530_ChIP-ChIP_U2OS_Human1.21668149
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20897424
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20892040
97DROSHA_22980978_ChIP-Seq_HELA_Human1.20121077
98RNF2_27304074_Chip-Seq_NSC_Mouse1.20076823
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.19673531
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19346055
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.18836107
102GBX2_23144817_ChIP-Seq_PC3_Human1.17438611
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17425306
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16998172
105FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16716782
106REST_18959480_ChIP-ChIP_MESCs_Mouse1.16123016
107SOX2_22085726_ChIP-Seq_NPCs_Mouse1.14691513
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.13619613
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12949191
110GF1_26923725_Chip-Seq_HPCs_Mouse1.12772597
111MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12582260
112PHF8_20622853_ChIP-Seq_HELA_Human1.09673149
113GATA3_21867929_ChIP-Seq_CD8_Mouse1.09522521
114KLF4_19829295_ChIP-Seq_ESCs_Human1.08691153
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08394703
116SMAD4_21799915_ChIP-Seq_A2780_Human1.08210417
117RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07482341
118SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06816852
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.06624331
120GATA6_21074721_ChIP-Seq_CACO-2_Human1.06284361
121GATA3_21867929_ChIP-Seq_TH1_Mouse1.05766626
122LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.05035097
123OCT4_19829295_ChIP-Seq_ESCs_Human1.04633000
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.04319999
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04271039
126CTCF_21964334_Chip-Seq_Bcells_Human1.03269879
127P53_22387025_ChIP-Seq_ESCs_Mouse1.03132403
128SPI1_20517297_ChIP-Seq_HL60_Human1.02834083
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02831238
130GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02400839
131CMYC_18555785_Chip-Seq_ESCs_Mouse1.02262302
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.01768598
133HOXB7_26014856_ChIP-Seq_BT474_Human1.01732969
134P53_21459846_ChIP-Seq_SAOS-2_Human1.00844854
135MYC_27129775_Chip-Seq_CORNEA_Mouse1.00796532
136* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00522969
137P300_19829295_ChIP-Seq_ESCs_Human1.00461347
138CSB_26484114_Chip-Seq_FIBROBLAST_Human1.00450886
139E2F1_17053090_ChIP-ChIP_MCF-7_Human0.99957763
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.98285328
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98209154
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97873854
143SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97750978
144CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97558437
145PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97558019
146SMRT_27268052_Chip-Seq_Bcells_Human0.97540389
147CTCF_27219007_Chip-Seq_Bcells_Human0.97439387
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96438800
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96312889
150GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95952261
151FUS_26573619_Chip-Seq_HEK293_Human0.95872405
152CRX_20693478_ChIP-Seq_RETINA_Mouse0.95842491
153PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95586748
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.95367442
155TBL1_22424771_ChIP-Seq_293T_Human0.94999812
156TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93685096
157PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93162812
158SOX9_26525672_Chip-Seq_HEART_Mouse0.92738852
159P300_18555785_Chip-Seq_ESCs_Mouse0.92715914
160KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92692833
161SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90907297
162JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.90735504
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90237599
164SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89240917
165SOX2_18555785_Chip-Seq_ESCs_Mouse0.88841200
166E2F1_18555785_Chip-Seq_ESCs_Mouse0.88526545
167SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87704726
168NFYB_21822215_ChIP-Seq_K562_Human0.87535916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.21205217
2MP0001929_abnormal_gametogenesis4.48154422
3MP0002161_abnormal_fertility/fecundity2.85624841
4MP0008877_abnormal_DNA_methylation2.79382777
5MP0003136_yellow_coat_color2.63532611
6MP0002210_abnormal_sex_determination2.56988536
7MP0003718_maternal_effect2.49070435
8MP0005670_abnormal_white_adipose2.47574178
9MP0000678_abnormal_parathyroid_gland2.21144183
10MP0005423_abnormal_somatic_nervous2.20233292
11MP0001145_abnormal_male_reproductive2.18366839
12MP0004859_abnormal_synaptic_plasticity2.16487221
13MP0009046_muscle_twitch2.09879504
14MP0001984_abnormal_olfaction2.07863720
15MP0005410_abnormal_fertilization14.4764456
16MP0005623_abnormal_meninges_morphology1.92495374
17MP0000653_abnormal_sex_gland1.88672316
18MP0003635_abnormal_synaptic_transmissio1.80959504
19MP0003011_delayed_dark_adaptation1.68883250
20MP0004233_abnormal_muscle_weight1.67029293
21MP0002132_abnormal_respiratory_system1.62143027
22MP0003880_abnormal_central_pattern1.60582737
23MP0003646_muscle_fatigue1.49559987
24MP0002249_abnormal_larynx_morphology1.48583468
25MP0005379_endocrine/exocrine_gland_phen1.44896327
26MP0002572_abnormal_emotion/affect_behav1.43647857
27MP0005551_abnormal_eye_electrophysiolog1.43174591
28MP0002063_abnormal_learning/memory/cond1.42641336
29MP0001486_abnormal_startle_reflex1.42160612
30MP0001968_abnormal_touch/_nociception1.41495131
31MP0001485_abnormal_pinna_reflex1.40199755
32MP0004270_analgesia1.38526479
33MP0002653_abnormal_ependyma_morphology1.35736522
34MP0009745_abnormal_behavioral_response1.35217531
35MP0002064_seizures1.31756016
36MP0002272_abnormal_nervous_system1.30700159
37MP0002736_abnormal_nociception_after1.28919613
38MP0009053_abnormal_anal_canal1.27119381
39MP0004742_abnormal_vestibular_system1.24149778
40MP0005310_abnormal_salivary_gland1.23973557
41MP0000569_abnormal_digit_pigmentation1.23894856
42MP0000534_abnormal_ureter_morphology1.20416683
43MP0001765_abnormal_ion_homeostasis1.16428454
44MP0005451_abnormal_body_composition1.15856498
45MP0003329_amyloid_beta_deposits1.10428319
46MP0001529_abnormal_vocalization1.10045784
47MP0002102_abnormal_ear_morphology1.09096640
48MP0001440_abnormal_grooming_behavior1.07025381
49MP0005395_other_phenotype1.06611859
50MP0002160_abnormal_reproductive_system1.03926699
51MP0005171_absent_coat_pigmentation1.00860800
52MP0002282_abnormal_trachea_morphology0.98613748
53MP0008569_lethality_at_weaning0.98501466
54MP0000026_abnormal_inner_ear0.98252482
55MP0002234_abnormal_pharynx_morphology0.97237578
56MP0002127_abnormal_cardiovascular_syste0.96663999
57MP0005083_abnormal_biliary_tract0.92759685
58MP0001986_abnormal_taste_sensitivity0.90135235
59MP0005645_abnormal_hypothalamus_physiol0.89741029
60MP0002067_abnormal_sensory_capabilities0.89737448
61MP0001502_abnormal_circadian_rhythm0.89241175
62MP0008961_abnormal_basal_metabolism0.87703906
63MP0003787_abnormal_imprinting0.87072831
64MP0001501_abnormal_sleep_pattern0.87001808
65MP0003077_abnormal_cell_cycle0.86137984
66MP0003879_abnormal_hair_cell0.84555236
67MP0009115_abnormal_fat_cell0.84098442
68MP0000681_abnormal_thyroid_gland0.83849655
69MP0001905_abnormal_dopamine_level0.80876004
70MP0005666_abnormal_adipose_tissue0.80784385
71MP0004811_abnormal_neuron_physiology0.79807956
72MP0003115_abnormal_respiratory_system0.79463231
73MP0000049_abnormal_middle_ear0.78985762
74MP0003959_abnormal_lean_body0.78052846
75MP0009697_abnormal_copulation0.76166727
76MP0002557_abnormal_social/conspecific_i0.75959901
77MP0002734_abnormal_mechanical_nocicepti0.75880712
78MP0008995_early_reproductive_senescence0.75023463
79MP0005248_abnormal_Harderian_gland0.75022629
80MP0005253_abnormal_eye_physiology0.74564301
81MP0004957_abnormal_blastocyst_morpholog0.74186335
82MP0004145_abnormal_muscle_electrophysio0.73972318
83MP0002735_abnormal_chemical_nociception0.73471306
84MP0002138_abnormal_hepatobiliary_system0.73464318
85MP0005174_abnormal_tail_pigmentation0.72648973
86MP0003633_abnormal_nervous_system0.72537317
87MP0000566_synostosis0.68120151
88MP0002822_catalepsy0.67984203
89MP0002882_abnormal_neuron_morphology0.67003958
90MP0004036_abnormal_muscle_relaxation0.66560377
91MP0000751_myopathy0.65959151
92MP0004142_abnormal_muscle_tone0.64973222
93MP0002066_abnormal_motor_capabilities/c0.64543762
94MP0002184_abnormal_innervation0.64534032
95MP0002152_abnormal_brain_morphology0.62624019
96MP0001348_abnormal_lacrimal_gland0.62609354
97MP0004510_myositis0.62189836
98MP0002752_abnormal_somatic_nervous0.61927718
99MP0002909_abnormal_adrenal_gland0.61836974
100MP0000516_abnormal_urinary_system0.60689608
101MP0005367_renal/urinary_system_phenotyp0.60689608
102MP0005647_abnormal_sex_gland0.60217193
103MP0005375_adipose_tissue_phenotype0.59443673
104MP0003631_nervous_system_phenotype0.58576725
105MP0003137_abnormal_impulse_conducting0.56471110
106MP0006072_abnormal_retinal_apoptosis0.55915040
107MP0005409_darkened_coat_color0.55752186
108MP0002229_neurodegeneration0.55341050
109MP0002928_abnormal_bile_duct0.54633426
110MP0001346_abnormal_lacrimal_gland0.53520929
111MP0005377_hearing/vestibular/ear_phenot0.53482271
112MP0003878_abnormal_ear_physiology0.53482271
113MP0000955_abnormal_spinal_cord0.53229204
114MP0005386_behavior/neurological_phenoty0.52173114
115MP0004924_abnormal_behavior0.52173114
116MP0001188_hyperpigmentation0.50586651
117MP0005167_abnormal_blood-brain_barrier0.50319813
118MP0003699_abnormal_female_reproductive0.49946254
119MP0005391_vision/eye_phenotype0.49842843
120MP0004484_altered_response_of0.49528056
121MP0004043_abnormal_pH_regulation0.49426086
122MP0002733_abnormal_thermal_nociception0.49372633
123MP0003950_abnormal_plasma_membrane0.49104128
124MP0006292_abnormal_olfactory_placode0.48995967
125MP0000003_abnormal_adipose_tissue0.48882699
126MP0005535_abnormal_body_temperature0.48798662
127MP0000920_abnormal_myelination0.48626878
128MP0001324_abnormal_eye_pigmentation0.47608625
129MP0000604_amyloidosis0.47319916
130MP0001963_abnormal_hearing_physiology0.46718394
131MP0001727_abnormal_embryo_implantation0.46660215
132MP0001879_abnormal_lymphatic_vessel0.46262809
133MP0003693_abnormal_embryo_hatching0.46237227
134MP0000778_abnormal_nervous_system0.46155166
135MP0005195_abnormal_posterior_eye0.45670113
136MP0005389_reproductive_system_phenotype0.44774537
137MP0004215_abnormal_myocardial_fiber0.44267910
138MP0004885_abnormal_endolymph0.43278972
139MP0000613_abnormal_salivary_gland0.42816309
140MP0000470_abnormal_stomach_morphology0.42701674
141MP0004085_abnormal_heartbeat0.41959504
142MP0001970_abnormal_pain_threshold0.41285396
143MP0003861_abnormal_nervous_system0.40619585
144MP0001666_abnormal_nutrient_absorption0.40530820
145MP0006276_abnormal_autonomic_nervous0.39892182
146MP0003045_fibrosis0.39196478
147MP0005636_abnormal_mineral_homeostasis0.37100303
148MP0008872_abnormal_physiological_respon0.36521983
149MP0003936_abnormal_reproductive_system0.36026871
150MP0003091_abnormal_cell_migration0.34257292
151MP0008789_abnormal_olfactory_epithelium0.33597562
152MP0001299_abnormal_eye_distance/0.32543249
153MP0000015_abnormal_ear_pigmentation0.31219524
154MP0005332_abnormal_amino_acid0.30043233

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.59698417
2Abnormal respiratory motile cilium morphology (HP:0005938)8.59698417
3Abnormal respiratory motile cilium physiology (HP:0012261)8.46739894
4Severe visual impairment (HP:0001141)7.37675416
5Abnormal ciliary motility (HP:0012262)6.75807278
6Rhinitis (HP:0012384)6.67546089
7Infertility (HP:0000789)6.33177789
8Chronic bronchitis (HP:0004469)6.13289159
9Bony spicule pigmentary retinopathy (HP:0007737)5.25404104
10Nasal polyposis (HP:0100582)5.20860006
11Chronic hepatic failure (HP:0100626)5.04983318
12Asymmetric septal hypertrophy (HP:0001670)4.96772444
13Resting tremor (HP:0002322)4.57797103
14Cone-rod dystrophy (HP:0000548)4.40377001
15Abnormality of the nasal mucosa (HP:0000433)4.23098327
16Male infertility (HP:0003251)4.07034644
17Hyperkalemia (HP:0002153)4.02281577
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.96523377
19Nephronophthisis (HP:0000090)3.93572262
20Bronchiectasis (HP:0002110)3.77488873
21Hypoplasia of the thymus (HP:0000778)3.67507753
22Enlarged epiphyses (HP:0010580)3.66027305
23Bronchitis (HP:0012387)3.65128151
24Bell-shaped thorax (HP:0001591)3.63838208
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.62044116
26Abnormal rod and cone electroretinograms (HP:0008323)3.37971162
27Potter facies (HP:0002009)3.36421631
28Facial shape deformation (HP:0011334)3.36421631
29Hypoplastic ischia (HP:0003175)3.31639466
30Hypoalphalipoproteinemia (HP:0003233)3.10917379
31Abnormality of the costochondral junction (HP:0000919)3.07578370
32Renovascular hypertension (HP:0100817)3.04898832
33Abnormal spermatogenesis (HP:0008669)3.04541827
34Abnormality of the ischium (HP:0003174)2.93301452
35Recurrent otitis media (HP:0000403)2.90458660
36Abnormality of the renal medulla (HP:0100957)2.87239317
37Recurrent sinusitis (HP:0011108)2.84578301
38Progressive sensorineural hearing impairment (HP:0000408)2.80347712
39Abnormal gallbladder physiology (HP:0012438)2.79211138
40Cholecystitis (HP:0001082)2.79211138
41Abnormality of midbrain morphology (HP:0002418)2.74643773
42Molar tooth sign on MRI (HP:0002419)2.74643773
43Abnormal urine output (HP:0012590)2.72904865
44Amelogenesis imperfecta (HP:0000705)2.70039973
45Generalized aminoaciduria (HP:0002909)2.67592461
46Abnormality of the hepatic vasculature (HP:0006707)2.57733091
47Unilateral renal agenesis (HP:0000122)2.57181852
48Truncal obesity (HP:0001956)2.57150740
49Abnormality of dental color (HP:0011073)2.53410114
50Choroideremia (HP:0001139)2.52833611
51Medial flaring of the eyebrow (HP:0010747)2.50899634
52Neurofibrillary tangles (HP:0002185)2.49313427
53Hypophosphatemic rickets (HP:0004912)2.47210322
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.46210283
55Portal hypertension (HP:0001409)2.40245452
56Double outlet right ventricle (HP:0001719)2.39634214
57Congenital malformation of the right heart (HP:0011723)2.39634214
58Menstrual irregularities (HP:0000858)2.39548712
59Abnormality of the parathyroid morphology (HP:0011766)2.33768192
60Renal dysplasia (HP:0000110)2.31031737
61Abnormality of the aortic arch (HP:0012303)2.30843274
62Flattened epiphyses (HP:0003071)2.29570612
63Obsessive-compulsive behavior (HP:0000722)2.26012797
64Tubulointerstitial nephritis (HP:0001970)2.25040226
65Spastic tetraparesis (HP:0001285)2.24371134
66Widely patent fontanelles and sutures (HP:0004492)2.23166949
67Abnormality of potassium homeostasis (HP:0011042)2.22995150
68Polyuria (HP:0000103)2.22763018
69Pendular nystagmus (HP:0012043)2.20153412
70Decreased central vision (HP:0007663)2.19996684
71Cerebral inclusion bodies (HP:0100314)2.17792368
72Impulsivity (HP:0100710)2.16838881
73Tubular atrophy (HP:0000092)2.15420160
74Insulin-resistant diabetes mellitus (HP:0000831)2.14574100
75Dyschromatopsia (HP:0007641)2.13146788
76Progressive cerebellar ataxia (HP:0002073)2.12673402
77Epiphyseal dysplasia (HP:0002656)2.08303654
78Renal Fanconi syndrome (HP:0001994)2.03251762
79Dynein arm defect of respiratory motile cilia (HP:0012255)12.5082773
80Absent/shortened dynein arms (HP:0200106)12.5082773
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.5424835
82Recurrent bronchitis (HP:0002837)1.99687479
83Intellectual disability, moderate (HP:0002342)1.98793508
84Tubulointerstitial abnormality (HP:0001969)1.97154947
85Recurrent corneal erosions (HP:0000495)1.96657959
86Gonadotropin excess (HP:0000837)1.93978918
87Hemiparesis (HP:0001269)1.93769775
88Hyponatremia (HP:0002902)1.93127722
89Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90612534
90Focal motor seizures (HP:0011153)1.89576344
91Congenital stationary night blindness (HP:0007642)1.86333918
92Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83209065
93Absent epiphyses (HP:0010577)1.83209065
94Abnormal drinking behavior (HP:0030082)1.81406467
95Polydipsia (HP:0001959)1.81406467
96Heterotopia (HP:0002282)1.80756931
97Photophobia (HP:0000613)1.80117745
98Azoospermia (HP:0000027)1.80024849
99Abnormality of the epiphysis of the femoral head (HP:0010574)1.78271238
100Progressive hearing impairment (HP:0001730)1.77250566
101Amyotrophic lateral sclerosis (HP:0007354)1.76062769
102Osteomalacia (HP:0002749)1.74660477
103Sensory axonal neuropathy (HP:0003390)1.74020657
104Hypoplastic heart (HP:0001961)1.73143504
105Abnormality of the dental root (HP:0006486)1.72848867
106Taurodontia (HP:0000679)1.72848867
107Abnormality of permanent molar morphology (HP:0011071)1.72848867
108Epileptic encephalopathy (HP:0200134)1.72519282
109Aplasia/Hypoplasia of the thymus (HP:0010515)1.71276015
110Bile duct proliferation (HP:0001408)1.71167503
111Abnormal biliary tract physiology (HP:0012439)1.71167503
112Abnormality of macular pigmentation (HP:0008002)1.70573110
113Aplasia/Hypoplasia of the lens (HP:0008063)1.69861346
114Flat capital femoral epiphysis (HP:0003370)1.69659664
115Sandal gap (HP:0001852)1.68514497
116Gait imbalance (HP:0002141)1.66808034
117Stage 5 chronic kidney disease (HP:0003774)1.66554761
118Optic nerve hypoplasia (HP:0000609)1.66164735
119Hyperuricemia (HP:0002149)1.65911790
120Increased purine levels (HP:0004368)1.65911790
121Impaired vibration sensation in the lower limbs (HP:0002166)1.65287275
122Abnormality of femoral epiphyses (HP:0006499)1.65181580
123Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.65181580
124Hypoalbuminemia (HP:0003073)1.64633687
125Abnormal albumin level (HP:0012116)1.64633687
126Bradycardia (HP:0001662)1.63374472
127Dysdiadochokinesis (HP:0002075)1.60960416
128Abnormality of molar morphology (HP:0011070)1.59738793
129Abnormality of molar (HP:0011077)1.59738793
130Tubulointerstitial fibrosis (HP:0005576)1.57984314
131Absent eyebrow (HP:0002223)1.57954788
132Exercise-induced myalgia (HP:0003738)1.57880232
133Abnormality of the dental pulp (HP:0006479)1.55943404
134Supranuclear gaze palsy (HP:0000605)1.55771865
135Peripheral hypomyelination (HP:0007182)1.53021120
136Postaxial hand polydactyly (HP:0001162)1.52677407
137Oculomotor apraxia (HP:0000657)1.52393131
138Congenital primary aphakia (HP:0007707)1.52157882
139Neuronal loss in central nervous system (HP:0002529)1.51315127
140Abnormality of renal excretion (HP:0011036)1.51251265
141Postural instability (HP:0002172)1.50373045
142Visual hallucinations (HP:0002367)1.48850543
143Gaze-evoked nystagmus (HP:0000640)1.48079179
144Postaxial foot polydactyly (HP:0001830)1.47762935
145Abnormality of the lower motor neuron (HP:0002366)1.47497535
146Retinal dysplasia (HP:0007973)1.45242905
147Decreased electroretinogram (ERG) amplitude (HP:0000654)1.45047277
148Bundle branch block (HP:0011710)1.42967659
149Congenital hepatic fibrosis (HP:0002612)1.42819421
150Vaginal atresia (HP:0000148)1.42793378
151Abnormality of saccadic eye movements (HP:0000570)1.41338263
152Abnormality of ocular smooth pursuit (HP:0000617)1.40565821
153Focal seizures (HP:0007359)1.39312949
154Myokymia (HP:0002411)1.38478291
155Polyphagia (HP:0002591)1.34669135
156Genital tract atresia (HP:0001827)1.34629532
157Impaired smooth pursuit (HP:0007772)1.33633169
158Febrile seizures (HP:0002373)1.32979261
159Constricted visual fields (HP:0001133)1.32591374
160Attenuation of retinal blood vessels (HP:0007843)1.32205029
161Hyperventilation (HP:0002883)1.30772241
162Genetic anticipation (HP:0003743)1.30290364
163Nephrogenic diabetes insipidus (HP:0009806)1.28764251
164Hypoplasia of the capital femoral epiphysis (HP:0003090)1.28342114
165Abnormality of the corticospinal tract (HP:0002492)1.28108024
166Degeneration of the lateral corticospinal tracts (HP:0002314)1.27941867

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.89124252
2PDK46.74722161
3PDK36.74722161
4TESK16.11605063
5PRKD35.56906565
6ICK4.57303052
7PDK24.26051694
8DDR23.98748832
9BRD43.63925714
10INSRR3.35328524
11PTK2B2.44601627
12MAP4K22.37266107
13PNCK2.35825369
14STK382.19544718
15STK392.02697347
16STK38L2.01978044
17PIK3CG1.90557361
18WNK41.70124610
19RIPK41.68570690
20NEK61.67386203
21MST1R1.66307711
22DYRK1B1.57541161
23CDK121.46895729
24CDK71.43774568
25EPHA41.37467702
26PDK11.29689645
27NTRK21.21209851
28PAK61.18553554
29WNK11.09568236
30TYRO31.06341695
31PHKG11.03964737
32PHKG21.03964737
33NTRK31.02680141
34PRKCG0.98000541
35MARK10.96303004
36CAMK1D0.95093490
37PDPK10.88876834
38CAMK1G0.87146396
39NEK20.86536359
40MAPK150.77113241
41CDK40.76386225
42SIK20.72754852
43MINK10.72593337
44MAP3K110.70145791
45MAP3K90.69319962
46AKT30.64613536
47MAP3K20.64208302
48MARK20.62697047
49MAPKAPK50.62649925
50LMTK20.62476970
51PRKG20.62240724
52PKN10.61758768
53TLK10.61444939
54TESK20.60178759
55CDK20.59939464
56PRKAA20.57818377
57CDK10.55370290
58MAP2K20.54332870
59LATS20.53743863
60RPS6KA10.53686072
61IRAK10.53260064
62MAP2K70.52985742
63CAMK2A0.52517307
64PINK10.51549634
65GRK10.51180589
66CDK30.50115806
67EEF2K0.50076513
68MAP3K40.49899350
69STK110.49851689
70ROCK10.49424397
71DYRK30.49356295
72UHMK10.49320524
73CDK150.47288183
74RPS6KA20.46647972
75MAP3K80.46497440
76MUSK0.45577527
77CDK180.43978469
78CAMKK10.43963120
79CCNB10.42178690
80MTOR0.41956461
81LATS10.41414010
82CDK11A0.40711132
83MAPK10.40310100
84CDK140.39828314
85CDK50.39006348
86PRKCZ0.38102697
87BLK0.37592734
88KSR20.37275932
89TIE10.36032722
90PAK20.35590740
91STK30.34965287
92SGK4940.34165218
93SGK2230.34165218
94TNIK0.33194623
95CASK0.32918989
96MAP2K60.32500877
97PLK10.32409964
98NUAK10.32252641
99CHEK20.31319038
100DAPK20.30158763
101VRK10.30002111
102PAK10.29708148
103ALK0.29243853
104PRKCQ0.27053085
105PRKAA10.26838147
106SGK10.26095560
107DYRK20.25835995
108GRK50.25433140
109MKNK20.25386454
110TAOK10.24898343
111BRSK10.24821055
112TTK0.24752640
113RPS6KL10.24681567
114RPS6KC10.24681567
115MAPK130.24615750
116MAP3K100.24513780
117CSNK1D0.24448417
118CAMK10.24136708
119MAPK140.23654938
120RPS6KA60.23375235
121PLK20.22804276
122PRKG10.22743174
123VRK20.22610010
124OBSCN0.22222771
125AURKA0.21299576
126PRKCB0.21201882
127ARAF0.21054917
128PRKCA0.20829847
129MAP2K40.20754029
130ACVR1B0.20631400
131RPS6KA30.19179547
132DYRK1A0.18671788
133RPS6KB10.18012889
134CLK10.17431948
135TAF10.17180879
136CAMK2B0.17003520
137BMPR1B0.16732447
138PRKACA0.16061903
139MAP3K10.16046116
140MAPK100.15776746
141CAMK2D0.15593433
142CHEK10.15514140
143GSK3B0.14981165
144PRKACG0.14887918
145DMPK0.14485422
146CAMK40.14294178
147BMPR20.13037874
148PAK30.12693257
149GRK70.12200877
150EPHB20.11917001
151MAPK80.11904804
152AKT10.11527412
153OXSR10.11270872
154BRAF0.10679593
155FES0.10668824
156MAPK110.09519594
157MAP2K10.09306417

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.31902508
2Fatty acid biosynthesis_Homo sapiens_hsa000614.08865488
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.93188542
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.80335434
5Butanoate metabolism_Homo sapiens_hsa006502.54291680
6Amphetamine addiction_Homo sapiens_hsa050312.50041846
7Nicotine addiction_Homo sapiens_hsa050332.31643363
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.31004626
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18227264
10Synaptic vesicle cycle_Homo sapiens_hsa047212.17485367
11Olfactory transduction_Homo sapiens_hsa047402.05270633
12Glucagon signaling pathway_Homo sapiens_hsa049222.04065090
13Pyruvate metabolism_Homo sapiens_hsa006201.97633655
14Long-term potentiation_Homo sapiens_hsa047201.97598719
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96185474
16Renin secretion_Homo sapiens_hsa049241.93751731
17Linoleic acid metabolism_Homo sapiens_hsa005911.93532424
18RNA transport_Homo sapiens_hsa030131.92834479
19Cardiac muscle contraction_Homo sapiens_hsa042601.87884758
20Circadian entrainment_Homo sapiens_hsa047131.75251888
21Insulin secretion_Homo sapiens_hsa049111.74726285
22Collecting duct acid secretion_Homo sapiens_hsa049661.68468843
23Salivary secretion_Homo sapiens_hsa049701.63817229
24Glutamatergic synapse_Homo sapiens_hsa047241.60272351
25Phenylalanine metabolism_Homo sapiens_hsa003601.60113509
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58825752
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.56328958
28Mineral absorption_Homo sapiens_hsa049781.54555488
29Taste transduction_Homo sapiens_hsa047421.44769825
30Calcium signaling pathway_Homo sapiens_hsa040201.44596085
31Morphine addiction_Homo sapiens_hsa050321.41134334
32Dorso-ventral axis formation_Homo sapiens_hsa043201.39557984
33Glycerolipid metabolism_Homo sapiens_hsa005611.38573733
34Gastric acid secretion_Homo sapiens_hsa049711.36613573
35Sulfur relay system_Homo sapiens_hsa041221.29893123
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29220683
37Oocyte meiosis_Homo sapiens_hsa041141.28573743
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26751091
39GABAergic synapse_Homo sapiens_hsa047271.26006816
40Vitamin B6 metabolism_Homo sapiens_hsa007501.25240594
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24651614
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21806329
43Propanoate metabolism_Homo sapiens_hsa006401.20029497
44Ether lipid metabolism_Homo sapiens_hsa005651.19293161
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18356054
46Dopaminergic synapse_Homo sapiens_hsa047281.15457825
47PPAR signaling pathway_Homo sapiens_hsa033201.12876035
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11619864
49Phototransduction_Homo sapiens_hsa047441.07830078
50Type I diabetes mellitus_Homo sapiens_hsa049401.06405297
51cAMP signaling pathway_Homo sapiens_hsa040241.06202037
52Estrogen signaling pathway_Homo sapiens_hsa049151.04456387
53Arginine and proline metabolism_Homo sapiens_hsa003301.04250933
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02336716
55Base excision repair_Homo sapiens_hsa034101.01062155
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00087136
57Cocaine addiction_Homo sapiens_hsa050301.00075283
58Autoimmune thyroid disease_Homo sapiens_hsa053200.98410937
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.96809554
60Allograft rejection_Homo sapiens_hsa053300.96423367
61Oxytocin signaling pathway_Homo sapiens_hsa049210.95683756
62Protein digestion and absorption_Homo sapiens_hsa049740.94710178
63Arginine biosynthesis_Homo sapiens_hsa002200.90305107
64Thyroid hormone synthesis_Homo sapiens_hsa049180.87221206
65Homologous recombination_Homo sapiens_hsa034400.86179943
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85099524
67Basal transcription factors_Homo sapiens_hsa030220.84545059
68Fatty acid metabolism_Homo sapiens_hsa012120.83402163
69Fructose and mannose metabolism_Homo sapiens_hsa000510.82616124
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82235248
71Antigen processing and presentation_Homo sapiens_hsa046120.81400265
72Cholinergic synapse_Homo sapiens_hsa047250.77246688
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76909355
74Purine metabolism_Homo sapiens_hsa002300.76317965
75Hedgehog signaling pathway_Homo sapiens_hsa043400.75708747
76Long-term depression_Homo sapiens_hsa047300.75269336
77Bile secretion_Homo sapiens_hsa049760.75071751
78Serotonergic synapse_Homo sapiens_hsa047260.73557980
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73513974
80Graft-versus-host disease_Homo sapiens_hsa053320.73298549
81Pancreatic secretion_Homo sapiens_hsa049720.71549267
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69607062
83Renin-angiotensin system_Homo sapiens_hsa046140.67824872
84Tyrosine metabolism_Homo sapiens_hsa003500.65327607
85Axon guidance_Homo sapiens_hsa043600.65221171
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64937921
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.64055596
88VEGF signaling pathway_Homo sapiens_hsa043700.63710296
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.62822808
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.61787459
91Viral myocarditis_Homo sapiens_hsa054160.60555901
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60005435
93Alcoholism_Homo sapiens_hsa050340.58607103
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57980727
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57377008
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56941959
97Fatty acid degradation_Homo sapiens_hsa000710.55768353
98Endocytosis_Homo sapiens_hsa041440.55250511
99Type II diabetes mellitus_Homo sapiens_hsa049300.55149033
100Mismatch repair_Homo sapiens_hsa034300.53859048
101Biosynthesis of amino acids_Homo sapiens_hsa012300.53552768
102Retinol metabolism_Homo sapiens_hsa008300.51551167
103Influenza A_Homo sapiens_hsa051640.51417933
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.51231972
105Huntingtons disease_Homo sapiens_hsa050160.50720450
106Inositol phosphate metabolism_Homo sapiens_hsa005620.50504492
107ABC transporters_Homo sapiens_hsa020100.49558922
108MAPK signaling pathway_Homo sapiens_hsa040100.48801542
109Fat digestion and absorption_Homo sapiens_hsa049750.48455362
110Carbon metabolism_Homo sapiens_hsa012000.47028957
111Nitrogen metabolism_Homo sapiens_hsa009100.46233155
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45174175
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44386969
114DNA replication_Homo sapiens_hsa030300.42908340
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41706610
116Gap junction_Homo sapiens_hsa045400.40809438
117Tight junction_Homo sapiens_hsa045300.40554177
118Selenocompound metabolism_Homo sapiens_hsa004500.40376994
119Acute myeloid leukemia_Homo sapiens_hsa052210.38842630
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38424410
121mRNA surveillance pathway_Homo sapiens_hsa030150.38393805
122Pentose phosphate pathway_Homo sapiens_hsa000300.38180025
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37763627
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.37120531
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.36898896
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35503938
127Wnt signaling pathway_Homo sapiens_hsa043100.33667763
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33414419
129Melanogenesis_Homo sapiens_hsa049160.32980558
130Arachidonic acid metabolism_Homo sapiens_hsa005900.32518227
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32477686
132Metabolic pathways_Homo sapiens_hsa011000.32019935
133Fanconi anemia pathway_Homo sapiens_hsa034600.31463119
134Pyrimidine metabolism_Homo sapiens_hsa002400.31181693
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27818356
136RNA polymerase_Homo sapiens_hsa030200.27731096
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26515567
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.18915167
139mTOR signaling pathway_Homo sapiens_hsa041500.15053954

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