FNDC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.36611081
2keratinization (GO:0031424)5.15440087
3positive regulation of gamma-delta T cell activation (GO:0046645)4.86126174
4establishment of skin barrier (GO:0061436)4.54700115
5negative regulation of cell killing (GO:0031342)4.48728121
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.48728121
7regulation of cell communication by electrical coupling (GO:0010649)4.38006405
8prepulse inhibition (GO:0060134)4.34672078
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31305084
10histone H4-K8 acetylation (GO:0043982)4.27486669
11histone H4-K5 acetylation (GO:0043981)4.27486669
12response to histamine (GO:0034776)4.17258124
13neuronal action potential propagation (GO:0019227)3.99064147
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.96611093
15gamma-aminobutyric acid transport (GO:0015812)3.95655456
16adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.94373634
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.91737297
18B cell receptor signaling pathway (GO:0050853)3.90587961
19positive regulation of synaptic transmission, GABAergic (GO:0032230)3.87552775
20regulation of relaxation of muscle (GO:1901077)3.87478042
21regulation of water loss via skin (GO:0033561)3.86169252
22histone H4-K16 acetylation (GO:0043984)3.85493031
23locomotory exploration behavior (GO:0035641)3.82339282
24activated T cell proliferation (GO:0050798)3.82133127
25neurotransmitter uptake (GO:0001504)3.81675439
26auditory behavior (GO:0031223)3.80901456
27cAMP-mediated signaling (GO:0019933)3.75969794
28desmosome organization (GO:0002934)3.74077282
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70865896
30regulation of glutamate receptor signaling pathway (GO:1900449)3.70203171
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.69783171
32neurotransmitter transport (GO:0006836)3.63771927
33regulation of gamma-delta T cell differentiation (GO:0045586)3.63344022
34T cell selection (GO:0045058)3.59889015
35regulation of synaptic vesicle exocytosis (GO:2000300)3.55814139
36regulation of neuronal synaptic plasticity (GO:0048168)3.55407187
37cellular response to epinephrine stimulus (GO:0071872)3.53768041
38synaptic transmission, dopaminergic (GO:0001963)3.53168065
39regulation of lymphocyte chemotaxis (GO:1901623)3.49649608
40regulation of neurotransmitter levels (GO:0001505)3.46928234
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45930050
42drinking behavior (GO:0042756)3.45495424
43regulation of gamma-delta T cell activation (GO:0046643)3.43830252
44phosphorelay signal transduction system (GO:0000160)3.43010752
45tachykinin receptor signaling pathway (GO:0007217)3.42814265
46regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.41653752
47regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.41653752
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37305653
49negative regulation of actin filament bundle assembly (GO:0032232)3.37235754
50synaptic vesicle maturation (GO:0016188)3.37099664
51positive T cell selection (GO:0043368)3.34589927
52synaptic vesicle exocytosis (GO:0016079)3.33472404
53cAMP catabolic process (GO:0006198)3.32381073
54regulation of cardiac muscle cell contraction (GO:0086004)3.29660915
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.28703551
56regulation of neurotransmitter secretion (GO:0046928)3.28357348
57cellular potassium ion homeostasis (GO:0030007)3.27391860
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.25569321
59regulation of postsynaptic membrane potential (GO:0060078)3.23906898
60striatum development (GO:0021756)3.21549913
61transmission of nerve impulse (GO:0019226)3.21469330
62regulation of cAMP-dependent protein kinase activity (GO:2000479)3.19425438
63regulation of synapse structural plasticity (GO:0051823)3.16743564
64long-chain fatty acid biosynthetic process (GO:0042759)3.16595295
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16417230
66negative regulation of microtubule polymerization (GO:0031115)3.14477465
67regulation of voltage-gated calcium channel activity (GO:1901385)3.13755873
68negative regulation of stress fiber assembly (GO:0051497)3.09622834
69dopamine receptor signaling pathway (GO:0007212)3.09063719
70cellular response to monoamine stimulus (GO:0071868)3.08778766
71cellular response to catecholamine stimulus (GO:0071870)3.08778766
72negative regulation of heart contraction (GO:0045822)3.07990425
73vesicle transport along microtubule (GO:0047496)3.07395470
74mechanosensory behavior (GO:0007638)3.07114215
75negative regulation of protein localization to plasma membrane (GO:1903077)3.06733251
76positive regulation of neurotransmitter secretion (GO:0001956)3.06652476
77behavioral response to cocaine (GO:0048148)3.03800617
78vocalization behavior (GO:0071625)3.02964932
79cyclic nucleotide catabolic process (GO:0009214)3.01993511
80regulation of synaptic vesicle transport (GO:1902803)3.00114413
81postsynaptic membrane organization (GO:0001941)2.99051539
82thymic T cell selection (GO:0045061)2.97821777
83L-amino acid import (GO:0043092)2.96475443
84negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.96234389
85positive thymic T cell selection (GO:0045059)2.95721714
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95391655
87serine transport (GO:0032329)2.95098305
88activation of protein kinase A activity (GO:0034199)2.94324488
89neurotransmitter secretion (GO:0007269)2.94075754
90DNA deamination (GO:0045006)2.93790890
91protein localization to synapse (GO:0035418)2.93244174
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.93107275
93startle response (GO:0001964)2.92448507
94regulation of neurotransmitter transport (GO:0051588)2.91260314
95L-serine transport (GO:0015825)2.91192947
96positive regulation of B cell differentiation (GO:0045579)2.90570161
97positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.90056064
98cerebellar granule cell differentiation (GO:0021707)2.89513584
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89282252
100neurotransmitter-gated ion channel clustering (GO:0072578)2.87763293
101negative regulation of amino acid transport (GO:0051956)2.87554208
102neuron-neuron synaptic transmission (GO:0007270)2.87513169
103sodium ion export (GO:0071436)2.87186748
104regulation of glutamate secretion (GO:0014048)2.86812455
105negative regulation of T cell mediated immunity (GO:0002710)2.86352033
106positive regulation of calcium-mediated signaling (GO:0050850)2.84918373
107long-term synaptic potentiation (GO:0060291)2.84022657
108neuron cell-cell adhesion (GO:0007158)2.81524754
109regulation of synaptic transmission, dopaminergic (GO:0032225)2.81234725
110negative T cell selection (GO:0043383)2.80695552
111gamma-aminobutyric acid signaling pathway (GO:0007214)2.80603208
112positive regulation of catecholamine secretion (GO:0033605)2.79684336
113glycerophospholipid catabolic process (GO:0046475)2.79611236
114positive regulation of natural killer cell mediated immunity (GO:0002717)2.79583872
115clathrin coat assembly (GO:0048268)2.79527672
116adaptation of signaling pathway (GO:0023058)2.79225744
117membrane depolarization (GO:0051899)2.78628976
118positive regulation of neurotransmitter transport (GO:0051590)2.77937950
119regulation of female receptivity (GO:0045924)2.77420274
120glutamate secretion (GO:0014047)2.77149905
121regulation of B cell receptor signaling pathway (GO:0050855)2.76407805
122negative regulation of adaptive immune response (GO:0002820)2.75643107
123cerebellar Purkinje cell differentiation (GO:0021702)2.75572137
124cellular response to interleukin-15 (GO:0071350)2.75521616
125V(D)J recombination (GO:0033151)2.75285000
126response to epinephrine (GO:0071871)2.74177044
127positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73753710
128regulation of dendritic spine morphogenesis (GO:0061001)2.73147880
129regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72821373
130negative thymic T cell selection (GO:0045060)2.72699131
131serotonin metabolic process (GO:0042428)2.72213201
132response to auditory stimulus (GO:0010996)2.71763876
133keratinocyte differentiation (GO:0030216)2.71710470
134regulation of interleukin-5 production (GO:0032674)2.71520471
135regulation of neurotransmitter uptake (GO:0051580)2.70521125
136glutamate receptor signaling pathway (GO:0007215)2.69818534
137exploration behavior (GO:0035640)2.69491658
138regulation of synaptic plasticity (GO:0048167)2.69461606
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.69322964
140histone H3-K36 demethylation (GO:0070544)2.69307658
141synaptic transmission (GO:0007268)2.67846460
142social behavior (GO:0035176)2.65678431
143intraspecies interaction between organisms (GO:0051703)2.65678431
144female mating behavior (GO:0060180)2.64031542
145presynaptic membrane assembly (GO:0097105)2.63969688
146regulation of ARF protein signal transduction (GO:0032012)2.63938969
147layer formation in cerebral cortex (GO:0021819)2.63915661
148leukocyte aggregation (GO:0070486)2.62787693
149synaptic transmission, glutamatergic (GO:0035249)2.58341190
150regulation of excitatory postsynaptic membrane potential (GO:0060079)2.54730183
151response to interleukin-15 (GO:0070672)2.54542748
152G-protein coupled receptor internalization (GO:0002031)2.53674462
153regulation of synaptic transmission, GABAergic (GO:0032228)2.53222618
154positive regulation of membrane potential (GO:0045838)2.50368230
155long-term memory (GO:0007616)2.50083431
156multicellular organismal water homeostasis (GO:0050891)2.49616927
157dendritic spine morphogenesis (GO:0060997)2.48830820
158proline transport (GO:0015824)2.48643684
159regulation of vesicle fusion (GO:0031338)2.47013127
160positive regulation of synaptic transmission (GO:0050806)2.46344843
161vesicle targeting (GO:0006903)2.44948924
162tolerance induction (GO:0002507)2.44043634
163visual learning (GO:0008542)2.43939087
164regulation of synaptic transmission, glutamatergic (GO:0051966)2.43865204
165antigen receptor-mediated signaling pathway (GO:0050851)2.43601367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.21089747
2EZH2_22144423_ChIP-Seq_EOC_Human4.19477931
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.52754518
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.51599295
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.35554996
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.25956843
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.99823066
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.74363513
9MYC_22102868_ChIP-Seq_BL_Human2.38219989
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.36668616
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26938245
12DROSHA_22980978_ChIP-Seq_HELA_Human2.09992585
13REST_21632747_ChIP-Seq_MESCs_Mouse2.07728610
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05527376
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03487077
16AR_21572438_ChIP-Seq_LNCaP_Human1.98891781
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93578149
18DNAJC2_21179169_ChIP-ChIP_NT2_Human1.88742801
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84860516
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83981323
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83792656
22RUNX_20019798_ChIP-Seq_JUKART_Human1.83218010
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81665739
24VDR_21846776_ChIP-Seq_THP-1_Human1.79510444
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79378600
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78754303
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78039525
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73513580
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73451611
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.67234345
31KDM2B_26808549_Chip-Seq_DND41_Human1.67006080
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66019765
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62775805
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60599462
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60529566
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60266462
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57739067
38GBX2_23144817_ChIP-Seq_PC3_Human1.55882456
39TCF7_22412390_ChIP-Seq_EML_Mouse1.54922577
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.54874226
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50652257
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.47371368
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46008235
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46008235
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45474376
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45260432
47RXR_22108803_ChIP-Seq_LS180_Human1.44113551
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41226727
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.40133015
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36204680
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.33659489
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.32942149
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32783408
54SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31518361
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31368249
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.29838136
57SCL_19346495_ChIP-Seq_HPC-7_Human1.28766050
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27773496
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26428607
60UTX_26944678_Chip-Seq_JUKART_Human1.25557083
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25084944
62KDM2B_26808549_Chip-Seq_K562_Human1.23992211
63RNF2_27304074_Chip-Seq_NSC_Mouse1.22752103
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.22209392
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20624120
66AHR_22903824_ChIP-Seq_MCF-7_Human1.20449694
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20324996
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19850624
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19040652
70MYB_26560356_Chip-Seq_TH2_Human1.18695500
71TCF4_23295773_ChIP-Seq_U87_Human1.15230345
72MAF_26560356_Chip-Seq_TH1_Human1.14677245
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14549361
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.13306906
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12079692
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.11948537
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10977347
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10747535
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10656953
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10656953
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09681594
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08205229
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08086891
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07166859
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06310983
86SMAD4_21799915_ChIP-Seq_A2780_Human1.05731140
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05626312
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.05430828
89BCAT_22108803_ChIP-Seq_LS180_Human1.04244735
90VDR_24763502_ChIP-Seq_THP-1_Human1.04104130
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03771159
92TAF15_26573619_Chip-Seq_HEK293_Human1.03051841
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02870818
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02742500
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02513608
96SMAD3_21741376_ChIP-Seq_ESCs_Human1.01889581
97AR_25329375_ChIP-Seq_VCAP_Human1.00622730
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.00322883
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99599519
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.99365344
101SPI1_23127762_ChIP-Seq_K562_Human0.98522349
102SOX2_21211035_ChIP-Seq_LN229_Gbm0.98369273
103P53_22387025_ChIP-Seq_ESCs_Mouse0.97100763
104PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96343053
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96327731
106BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96148570
107ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95564811
108ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95548352
109E2F1_18555785_Chip-Seq_ESCs_Mouse0.95419997
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.94131012
111SMAD3_21741376_ChIP-Seq_EPCs_Human0.93917955
112ER_23166858_ChIP-Seq_MCF-7_Human0.93677222
113EED_16625203_ChIP-ChIP_MESCs_Mouse0.93581331
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92934757
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92512701
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91821789
117SMAD4_21741376_ChIP-Seq_ESCs_Human0.90917157
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89156817
119IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88663630
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87679449
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87174523
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87173250
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.87034779
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86490636
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85995785
126TP53_16413492_ChIP-PET_HCT116_Human0.85742599
127GATA3_27048872_Chip-Seq_THYMUS_Human0.85733330
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.85567441
129SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84437565
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84020317
131IRF8_27001747_Chip-Seq_BMDM_Mouse0.83763075
132SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83680499
133RUNX2_22187159_ChIP-Seq_PCA_Human0.83579159
134P300_19829295_ChIP-Seq_ESCs_Human0.83366380
135NMYC_18555785_Chip-Seq_ESCs_Mouse0.82817406
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82292245
137SMRT_27268052_Chip-Seq_Bcells_Human0.82087394
138IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82013583
139CBP_20019798_ChIP-Seq_JUKART_Human0.82013583
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81687951
141MYB_26560356_Chip-Seq_TH1_Human0.80836569
142AR_19668381_ChIP-Seq_PC3_Human0.80205163
143RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.80057767
144STAT3_23295773_ChIP-Seq_U87_Human0.79647330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.17191986
2MP0010234_abnormal_vibrissa_follicle3.94655124
3MP0002796_impaired_skin_barrier3.84582109
4MP0001968_abnormal_touch/_nociception2.95347835
5MP0003880_abnormal_central_pattern2.75700785
6MP0003635_abnormal_synaptic_transmissio2.66448882
7MP0005645_abnormal_hypothalamus_physiol2.65205263
8MP0005451_abnormal_body_composition2.61773457
9MP0009745_abnormal_behavioral_response2.46708286
10MP0005501_abnormal_skin_physiology2.39698218
11MP0003787_abnormal_imprinting2.33439215
12MP0002653_abnormal_ependyma_morphology2.33195439
13MP0002063_abnormal_learning/memory/cond2.29249789
14MP0002736_abnormal_nociception_after2.20377785
15MP0004947_skin_inflammation2.19218015
16MP0003303_peritoneal_inflammation2.14472043
17MP0002064_seizures2.03636180
18MP0009046_muscle_twitch2.02600217
19MP0001440_abnormal_grooming_behavior2.02252351
20MP0005423_abnormal_somatic_nervous1.98021252
21MP0002572_abnormal_emotion/affect_behav1.97667687
22MP0005275_abnormal_skin_tensile1.96675122
23MP0001800_abnormal_humoral_immune1.96420826
24MP0008961_abnormal_basal_metabolism1.90210975
25MP0004742_abnormal_vestibular_system1.87372555
26MP0003122_maternal_imprinting1.83501450
27MP0008877_abnormal_DNA_methylation1.82738119
28MP0010771_integument_phenotype1.78665658
29MP0005387_immune_system_phenotype1.75220075
30MP0001790_abnormal_immune_system1.75220075
31MP0003763_abnormal_thymus_physiology1.69018872
32MP0001501_abnormal_sleep_pattern1.67863244
33MP0000685_abnormal_immune_system1.61189995
34MP0001216_abnormal_epidermal_layer1.55646219
35MP0002254_reproductive_system_inflammat1.50185696
36MP0004142_abnormal_muscle_tone1.48820716
37MP0001529_abnormal_vocalization1.47146201
38MP0003172_abnormal_lysosome_physiology1.45591684
39MP0001984_abnormal_olfaction1.43970088
40MP0008569_lethality_at_weaning1.43795335
41MP0000569_abnormal_digit_pigmentation1.43245210
42MP0004270_analgesia1.42506882
43MP0003633_abnormal_nervous_system1.41265486
44MP0002822_catalepsy1.39813411
45MP0002067_abnormal_sensory_capabilities1.38602108
46MP0002166_altered_tumor_susceptibility1.38085193
47MP0003183_abnormal_peptide_metabolism1.37574629
48MP0000015_abnormal_ear_pigmentation1.37368384
49MP0003453_abnormal_keratinocyte_physiol1.33876483
50MP0008995_early_reproductive_senescence1.33737654
51MP0001486_abnormal_startle_reflex1.33238748
52MP0005000_abnormal_immune_tolerance1.32548107
53MP0002735_abnormal_chemical_nociception1.32217194
54MP0002066_abnormal_motor_capabilities/c1.29070153
55MP0002452_abnormal_antigen_presenting1.28952076
56MP0003121_genomic_imprinting1.27998429
57MP0004924_abnormal_behavior1.27442080
58MP0005386_behavior/neurological_phenoty1.27442080
59MP0001986_abnormal_taste_sensitivity1.27155851
60MP0010678_abnormal_skin_adnexa1.26738670
61MP0000427_abnormal_hair_cycle1.26715079
62MP0002723_abnormal_immune_serum1.26613520
63MP0002272_abnormal_nervous_system1.25396311
64MP0002420_abnormal_adaptive_immunity1.24741733
65MP0002006_tumorigenesis1.23958937
66MP0001970_abnormal_pain_threshold1.23162159
67MP0001188_hyperpigmentation1.22889861
68MP0002733_abnormal_thermal_nociception1.22121472
69MP0001819_abnormal_immune_cell1.22088395
70MP0004381_abnormal_hair_follicle1.21846650
71MP0002882_abnormal_neuron_morphology1.20963608
72MP0003300_gastrointestinal_ulcer1.20755513
73MP0001502_abnormal_circadian_rhythm1.20445597
74MP0002398_abnormal_bone_marrow1.19737333
75MP0003631_nervous_system_phenotype1.19208748
76MP0000703_abnormal_thymus_morphology1.16526758
77MP0005671_abnormal_response_to1.15891846
78MP0001835_abnormal_antigen_presentation1.14078988
79MP0002734_abnormal_mechanical_nocicepti1.11867437
80MP0003690_abnormal_glial_cell1.11823893
81MP0002557_abnormal_social/conspecific_i1.11386339
82MP0004484_altered_response_of1.07669385
83MP0002060_abnormal_skin_morphology1.07251634
84MP0003436_decreased_susceptibility_to1.06874419
85MP0004510_myositis1.05020234
86MP0002229_neurodegeneration1.04388676
87MP0000579_abnormal_nail_morphology1.02586867
88MP0005535_abnormal_body_temperature1.02414600
89MP0005076_abnormal_cell_differentiation1.00968175
90MP0003866_abnormal_defecation1.00570052
91MP0004130_abnormal_muscle_cell1.00396152
92MP0004811_abnormal_neuron_physiology1.00319640
93MP0003879_abnormal_hair_cell0.98674289
94MP0000716_abnormal_immune_system0.98546555
95MP0000955_abnormal_spinal_cord0.98061243
96MP0006276_abnormal_autonomic_nervous0.97608419
97MP0003329_amyloid_beta_deposits0.96773816
98MP0005167_abnormal_blood-brain_barrier0.91076021
99MP0002184_abnormal_innervation0.90888270
100MP0001963_abnormal_hearing_physiology0.90336123
101MP0009931_abnormal_skin_appearance0.90319256
102MP0000383_abnormal_hair_follicle0.90056207
103MP0008874_decreased_physiological_sensi0.90021756
104MP0005551_abnormal_eye_electrophysiolog0.89486937
105MP0000371_diluted_coat_color0.87781909
106MP0005646_abnormal_pituitary_gland0.86235276
107MP0001905_abnormal_dopamine_level0.86134710
108MP0002722_abnormal_immune_system0.85151510
109MP0004043_abnormal_pH_regulation0.84524686
110MP0004885_abnormal_endolymph0.84248694
111MP0000689_abnormal_spleen_morphology0.84187406
112MP0002909_abnormal_adrenal_gland0.83949858
113MP0008872_abnormal_physiological_respon0.83899415
114MP0009333_abnormal_splenocyte_physiolog0.80591893
115MP0005394_taste/olfaction_phenotype0.78777344
116MP0005499_abnormal_olfactory_system0.78777344
117MP0002152_abnormal_brain_morphology0.77707843
118MP0005310_abnormal_salivary_gland0.76821685
119MP0001873_stomach_inflammation0.76496549
120MP0000465_gastrointestinal_hemorrhage0.76444172
121MP0003123_paternal_imprinting0.76189419
122MP0000367_abnormal_coat/_hair0.75923027
123MP0004145_abnormal_muscle_electrophysio0.75370358
124MP0001191_abnormal_skin_condition0.75304188
125MP0000604_amyloidosis0.75235430
126MP0000920_abnormal_myelination0.74564589
127MP0009780_abnormal_chondrocyte_physiolo0.74078562
128MP0000377_abnormal_hair_follicle0.72872478
129MP0000647_abnormal_sebaceous_gland0.72473792
130MP0000778_abnormal_nervous_system0.72341966
131MP0003632_abnormal_nervous_system0.64942606
132MP0001485_abnormal_pinna_reflex0.62785075
133MP0001177_atelectasis0.62485531
134MP0008260_abnormal_autophagy0.60986904
135MP0002102_abnormal_ear_morphology0.59419372
136MP0001765_abnormal_ion_homeostasis0.57652630

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)5.11552371
2Papilloma (HP:0012740)4.72043133
3Verrucae (HP:0200043)4.72043133
4Conjunctival hamartoma (HP:0100780)4.30943036
5Fair hair (HP:0002286)4.04142976
6Abnormality of B cell number (HP:0010975)3.96936163
7B lymphocytopenia (HP:0010976)3.96936163
8Agammaglobulinemia (HP:0004432)3.89526990
9Focal motor seizures (HP:0011153)3.83171867
10Abnormality of alanine metabolism (HP:0010916)3.78021784
11Hyperalaninemia (HP:0003348)3.78021784
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.78021784
13Erythroderma (HP:0001019)3.72340422
14Abnormal hair whorl (HP:0010721)3.70573475
15Thyroiditis (HP:0100646)3.57370563
16Generalized hypopigmentation of hair (HP:0011358)3.56059096
17Chronic sinusitis (HP:0011109)3.53249912
18Hamartoma of the eye (HP:0010568)3.51262124
19Panhypogammaglobulinemia (HP:0003139)3.40681213
20Palmoplantar hyperkeratosis (HP:0000972)3.31948843
21Action tremor (HP:0002345)3.28006185
22Cellulitis (HP:0100658)3.21661616
23Spastic gait (HP:0002064)3.14484861
24Ankle clonus (HP:0011448)3.11473428
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.07931198
26Degeneration of the lateral corticospinal tracts (HP:0002314)3.07931198
27Plantar hyperkeratosis (HP:0007556)3.05977760
28Hemiplegia (HP:0002301)3.05622634
29Palmar hyperkeratosis (HP:0010765)3.02568094
30Gaze-evoked nystagmus (HP:0000640)3.01450286
31Erythema (HP:0010783)2.98152793
32Recurrent viral infections (HP:0004429)2.97032546
33Abnormality of the corticospinal tract (HP:0002492)2.96728544
34Focal seizures (HP:0007359)2.93223307
35Oligodactyly (hands) (HP:0001180)2.93179660
36Mild short stature (HP:0003502)2.93163328
37Hyperventilation (HP:0002883)2.85373639
38Sepsis (HP:0100806)2.82044451
39Atonic seizures (HP:0010819)2.79615900
40Genetic anticipation (HP:0003743)2.78740207
41Lower limb muscle weakness (HP:0007340)2.78555340
42Myokymia (HP:0002411)2.76968562
43Chronic otitis media (HP:0000389)2.76881175
44T lymphocytopenia (HP:0005403)2.76217828
45Abnormality of nail color (HP:0100643)2.70519695
46Limb dystonia (HP:0002451)2.69907810
47Poor eye contact (HP:0000817)2.69648899
48Abnormality of T cell number (HP:0011839)2.67330619
49Vertebral arch anomaly (HP:0008438)2.62495769
50Impaired vibratory sensation (HP:0002495)2.61806578
51Hypotrichosis (HP:0001006)2.61791756
52Absence seizures (HP:0002121)2.59715836
53Meningitis (HP:0001287)2.57233217
54Recurrent fungal infections (HP:0002841)2.56007722
55Hyperthyroidism (HP:0000836)2.48383906
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.47406725
57Status epilepticus (HP:0002133)2.44552216
58Recurrent bronchitis (HP:0002837)2.43680145
59Failure to thrive in infancy (HP:0001531)2.43244348
60Epileptiform EEG discharges (HP:0011182)2.43024321
61Polyphagia (HP:0002591)2.40212849
62Papilledema (HP:0001085)2.38416323
63Severe combined immunodeficiency (HP:0004430)2.38101592
64Tetraparesis (HP:0002273)2.37663281
65Abnormality of T cells (HP:0002843)2.37294316
66Increased circulating renin level (HP:0000848)2.34326035
67Supranuclear gaze palsy (HP:0000605)2.30070885
68Colitis (HP:0002583)2.30006188
69Lip pit (HP:0100267)2.29500432
70Febrile seizures (HP:0002373)2.28957712
71Congenital ichthyosiform erythroderma (HP:0007431)2.27858587
72Blue irides (HP:0000635)2.27558166
73Epileptic encephalopathy (HP:0200134)2.25377156
74Alacrima (HP:0000522)2.24763040
75Gastrointestinal inflammation (HP:0004386)2.24668925
76Urinary bladder sphincter dysfunction (HP:0002839)2.24526473
77Impaired smooth pursuit (HP:0007772)2.23855149
78Sleep apnea (HP:0010535)2.23514877
79Visual hallucinations (HP:0002367)2.19593873
80Inflammation of the large intestine (HP:0002037)2.19140807
81Abnormality of the labia minora (HP:0012880)2.18675321
82Slow saccadic eye movements (HP:0000514)2.18428117
83Woolly hair (HP:0002224)2.17862955
84Sparse scalp hair (HP:0002209)2.17824567
85EEG with generalized epileptiform discharges (HP:0011198)2.17618850
86Abnormal eating behavior (HP:0100738)2.17451097
87Hypoplasia of the thymus (HP:0000778)2.16709384
88Encephalitis (HP:0002383)2.16484354
89Ocular albinism (HP:0001107)2.14910169
90Volvulus (HP:0002580)2.14544665
91Thick nail (HP:0001805)2.14234683
92Dialeptic seizures (HP:0011146)2.14028224
93Bradykinesia (HP:0002067)2.13469804
94Impaired vibration sensation in the lower limbs (HP:0002166)2.13296355
95Hypoplastic nipples (HP:0002557)2.12895022
96Recurrent sinusitis (HP:0011108)2.12136258
97Generalized tonic-clonic seizures (HP:0002069)2.11938729
98Broad-based gait (HP:0002136)2.11820010
99Hypsarrhythmia (HP:0002521)2.11424151
100Macroorchidism (HP:0000053)2.10137759
101Eosinophilia (HP:0001880)2.09780953
102Gangrene (HP:0100758)2.09636548
103Abnormal social behavior (HP:0012433)2.09460436
104Impaired social interactions (HP:0000735)2.09460436
105Abnormality of the left ventricular outflow tract (HP:0011103)2.09446303
106Subaortic stenosis (HP:0001682)2.09446303
107Peripheral hypomyelination (HP:0007182)2.07482406
108Recurrent cutaneous fungal infections (HP:0011370)2.07140362
109Chronic mucocutaneous candidiasis (HP:0002728)2.07140362
110Eczematoid dermatitis (HP:0000976)2.04695862
111Milia (HP:0001056)2.04376697
112Glucose intolerance (HP:0000833)2.04336559
113Gastrointestinal stroma tumor (HP:0100723)2.03491394
114Dysautonomia (HP:0002459)2.02929413
115Aqueductal stenosis (HP:0002410)2.02922077
116Truncal ataxia (HP:0002078)2.02801564
117Iris hypopigmentation (HP:0007730)2.02761075
118Abnormal delayed hypersensitivity skin test (HP:0002963)2.01842918
119Clonus (HP:0002169)2.00587820
120Progressive inability to walk (HP:0002505)2.00146875
121Spinal canal stenosis (HP:0003416)1.99700466
122Urinary urgency (HP:0000012)1.98332332
123Ankyloglossia (HP:0010296)1.97599923
124Delusions (HP:0000746)1.97362639
125Neuronal loss in central nervous system (HP:0002529)1.96290301
126Stomatitis (HP:0010280)1.95557906
127Combined immunodeficiency (HP:0005387)1.95446867
128Decreased lacrimation (HP:0000633)1.93017313
129Small epiphyses (HP:0010585)1.92232353
130Mediastinal lymphadenopathy (HP:0100721)1.91592635
131Generalized hypotonia (HP:0001290)1.90983342
132Lower limb amyotrophy (HP:0007210)1.90869633
133Postural instability (HP:0002172)1.88480125
134Resting tremor (HP:0002322)1.86910565
135Progressive cerebellar ataxia (HP:0002073)1.85510773
136Dysmetric saccades (HP:0000641)1.85249409
137Open mouth (HP:0000194)1.84908329
138Amyotrophic lateral sclerosis (HP:0007354)1.84240131
139Ectropion (HP:0000656)1.83885142
140Mutism (HP:0002300)1.83791276
141Anxiety (HP:0000739)1.83192830
142Obstructive lung disease (HP:0006536)1.81511094
143Chronic obstructive pulmonary disease (HP:0006510)1.81511094
144IgG deficiency (HP:0004315)1.81022509
145Abnormality of ocular smooth pursuit (HP:0000617)1.80931752
146Abnormality of oral frenula (HP:0000190)1.80514261
147Paraplegia (HP:0010550)1.80314256
148Bowel incontinence (HP:0002607)1.79403794
149Excessive salivation (HP:0003781)1.78728601
150Drooling (HP:0002307)1.78728601
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78404111
152Spastic paraplegia (HP:0001258)1.78324332
153Truncal obesity (HP:0001956)1.77584868
154Ventricular fibrillation (HP:0001663)1.76880377
155Widely spaced teeth (HP:0000687)1.76274539
156Depression (HP:0000716)1.75949745
157Stereotypic behavior (HP:0000733)1.75904486
158Absent speech (HP:0001344)1.75902634
159Hemiparesis (HP:0001269)1.75793755
160Hamartoma (HP:0010566)1.75560599
161Abnormality of binocular vision (HP:0011514)1.75318040
162Diplopia (HP:0000651)1.75318040
163Abnormality of the fingertips (HP:0001211)1.75001214
164Osteomyelitis (HP:0002754)1.74971848
165Thyroid-stimulating hormone excess (HP:0002925)1.74683776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.89489868
2MAP3K93.88023545
3RIPK43.04453589
4SIK23.00542650
5NTRK32.96165909
6NTRK22.69345893
7GRK62.39061252
8MAP3K132.34844817
9CAMK42.21071569
10SIK32.13043258
11MAP4K12.12718232
12STK392.10731319
13MAP3K42.09634850
14WNK42.07325790
15SYK1.87224215
16EEF2K1.84602882
17EPHA41.83114056
18FES1.79288489
19CAMKK21.77550126
20KSR21.67431230
21BLK1.58943981
22TAOK31.58343177
23PIK3CG1.55838159
24SCYL21.55222585
25WNK11.45192110
26OXSR11.44285362
27GRK51.38029133
28TNK21.36434055
29MAP2K71.33369380
30KSR11.32977397
31MINK11.31482304
32TAOK11.30905314
33ITK1.29314407
34MAP3K121.21388994
35ERBB31.20966893
36ZAP701.20894858
37CASK1.20085638
38HCK1.19829556
39MARK11.18919975
40MAP4K21.16572347
41MARK21.16474622
42PINK11.14395929
43ERN11.13763393
44MAP2K41.13362323
45CAMK2A1.10188609
46MAP3K21.08088379
47MAP3K71.03353931
48DAPK21.00993268
49TRPM70.99932481
50PAK60.97414530
51CDK50.97347997
52CAMK2B0.96291532
53SGK30.96158657
54DYRK30.95510494
55FGFR30.95480333
56MARK30.94797123
57FGFR20.94750030
58PKN20.90359330
59ARAF0.90345748
60PRKCH0.89850461
61SGK20.88276148
62CCNB10.88092512
63MAP3K110.88055840
64MST40.87696324
65TNIK0.86974497
66TRIB30.85892692
67EPHA30.85847565
68BTK0.82672303
69ALK0.82584780
70BCR0.80360812
71MAP3K10.79947494
72BUB10.78681046
73FGR0.78547290
74MAPK130.77966424
75PDK10.76772290
76TXK0.75973846
77TYRO30.75883902
78CDK120.74606655
79FYN0.72441714
80SGK10.72389883
81MAP3K50.72346003
82MAP3K140.70962866
83RAF10.70684234
84JAK20.68337394
85SGK4940.68215134
86SGK2230.68215134
87STK110.67531508
88PRKCQ0.66983857
89MAPKAPK30.66664661
90LCK0.66535192
91MAPK120.66216932
92CSK0.64561617
93STK100.63499833
94UHMK10.61942023
95CAMK1G0.61078158
96PRKCZ0.60568190
97RET0.59768559
98FRK0.59398249
99MAPK100.59124068
100JAK10.57202580
101CSNK1A1L0.56964088
102RPS6KA20.54684497
103CSNK1G20.53849563
104CAMK10.52519492
105PKN10.52507464
106TLK10.51457297
107WNK30.51285597
108CDK190.50484081
109TEC0.49423841
110PRKCG0.48970208
111CDK140.48481610
112CAMKK10.48360774
113DYRK1A0.48124511
114LRRK20.48052792
115CDK180.47685862
116MAPK70.47556591
117BRAF0.46930346
118DYRK1B0.46803653
119PDPK10.46273178
120LYN0.45006091
121MAPK40.44986168
122PLK20.44984763
123BMPR20.44585307
124TSSK60.43706443
125JAK30.43234624
126EPHB10.42156261
127CDK150.41158167
128TYK20.40438280
129CAMK2G0.39511935
130HIPK20.38866368
131IKBKE0.37994567
132EGFR0.37479441
133MAP2K60.36950317
134PAK30.36425333
135RPS6KA30.36028364
136DAPK10.35796633
137CSNK1D0.35660125
138CSNK1G30.35339125
139PRKD30.35176583
140ERBB20.34763045
141PTK2B0.34715644

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.53900781
2Nicotine addiction_Homo sapiens_hsa050332.35418922
3Primary immunodeficiency_Homo sapiens_hsa053402.34947779
4Synaptic vesicle cycle_Homo sapiens_hsa047212.27436656
5B cell receptor signaling pathway_Homo sapiens_hsa046622.13017908
6Long-term potentiation_Homo sapiens_hsa047202.11934120
7Morphine addiction_Homo sapiens_hsa050322.10814374
8GABAergic synapse_Homo sapiens_hsa047271.85262665
9Dopaminergic synapse_Homo sapiens_hsa047281.82371656
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81716706
11Circadian entrainment_Homo sapiens_hsa047131.78322303
12Renin secretion_Homo sapiens_hsa049241.64342617
13Glutamatergic synapse_Homo sapiens_hsa047241.62880538
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57937954
15T cell receptor signaling pathway_Homo sapiens_hsa046601.56188567
16Amphetamine addiction_Homo sapiens_hsa050311.51825972
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.48802744
18Collecting duct acid secretion_Homo sapiens_hsa049661.48482971
19Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.47316356
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46873621
21Gastric acid secretion_Homo sapiens_hsa049711.44655511
22Long-term depression_Homo sapiens_hsa047301.41485656
23Salivary secretion_Homo sapiens_hsa049701.41368485
24Oxytocin signaling pathway_Homo sapiens_hsa049211.38948981
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37941142
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37603734
27Cholinergic synapse_Homo sapiens_hsa047251.36076758
28Cocaine addiction_Homo sapiens_hsa050301.31143872
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30143093
30Non-small cell lung cancer_Homo sapiens_hsa052231.30007750
31GnRH signaling pathway_Homo sapiens_hsa049121.28172986
32Serotonergic synapse_Homo sapiens_hsa047261.28022475
33Glioma_Homo sapiens_hsa052141.25364681
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23064484
35Type II diabetes mellitus_Homo sapiens_hsa049301.22984610
36Osteoclast differentiation_Homo sapiens_hsa043801.21363704
37Taste transduction_Homo sapiens_hsa047421.20449173
38Phototransduction_Homo sapiens_hsa047441.20408187
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19333876
40Calcium signaling pathway_Homo sapiens_hsa040201.15979674
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13951999
42VEGF signaling pathway_Homo sapiens_hsa043701.12247248
43Estrogen signaling pathway_Homo sapiens_hsa049151.10460351
44Chemokine signaling pathway_Homo sapiens_hsa040621.09610857
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09395817
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.08679083
47ErbB signaling pathway_Homo sapiens_hsa040121.04154159
48Insulin secretion_Homo sapiens_hsa049111.02677248
49Alcoholism_Homo sapiens_hsa050341.01261199
50MAPK signaling pathway_Homo sapiens_hsa040100.99061068
51Type I diabetes mellitus_Homo sapiens_hsa049400.98972395
52Dorso-ventral axis formation_Homo sapiens_hsa043200.91758938
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90859189
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.90233380
55Gap junction_Homo sapiens_hsa045400.88560580
56cAMP signaling pathway_Homo sapiens_hsa040240.88138629
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87464561
58Inositol phosphate metabolism_Homo sapiens_hsa005620.86770626
59Axon guidance_Homo sapiens_hsa043600.86691532
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85773504
61Fatty acid biosynthesis_Homo sapiens_hsa000610.85257286
62Regulation of autophagy_Homo sapiens_hsa041400.84700018
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.83246403
64Vibrio cholerae infection_Homo sapiens_hsa051100.82996937
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80392909
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80388334
67Choline metabolism in cancer_Homo sapiens_hsa052310.79908765
68Platelet activation_Homo sapiens_hsa046110.78527655
69Chronic myeloid leukemia_Homo sapiens_hsa052200.76732515
70Melanogenesis_Homo sapiens_hsa049160.76249154
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75010023
72Tuberculosis_Homo sapiens_hsa051520.74349767
73Endometrial cancer_Homo sapiens_hsa052130.73553260
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.71550920
75Acute myeloid leukemia_Homo sapiens_hsa052210.70500902
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70338048
77mTOR signaling pathway_Homo sapiens_hsa041500.70174584
78Renal cell carcinoma_Homo sapiens_hsa052110.67690100
79Pancreatic cancer_Homo sapiens_hsa052120.66000159
80Ras signaling pathway_Homo sapiens_hsa040140.65770248
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64530519
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.63670988
83Thyroid hormone synthesis_Homo sapiens_hsa049180.62043205
84Endocytosis_Homo sapiens_hsa041440.61937327
85FoxO signaling pathway_Homo sapiens_hsa040680.61826179
86Circadian rhythm_Homo sapiens_hsa047100.60923658
87Pancreatic secretion_Homo sapiens_hsa049720.60690104
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60298088
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.60104012
90Colorectal cancer_Homo sapiens_hsa052100.57574243
91Salmonella infection_Homo sapiens_hsa051320.55932254
92Insulin signaling pathway_Homo sapiens_hsa049100.55446350
93Leishmaniasis_Homo sapiens_hsa051400.55159726
94Prolactin signaling pathway_Homo sapiens_hsa049170.53746068
95Ovarian steroidogenesis_Homo sapiens_hsa049130.53657595
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53624334
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53351577
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53027286
99Oocyte meiosis_Homo sapiens_hsa041140.51771531
100Hematopoietic cell lineage_Homo sapiens_hsa046400.51365215
101Ether lipid metabolism_Homo sapiens_hsa005650.50664966
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50627364
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50023203
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.49600435
105Hepatitis B_Homo sapiens_hsa051610.48424116
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48211198
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.45630700
108Glucagon signaling pathway_Homo sapiens_hsa049220.45630385
109Rheumatoid arthritis_Homo sapiens_hsa053230.45330124
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45259556
111Measles_Homo sapiens_hsa051620.44574473
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.44342162
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.41165979
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39746994
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39484739
116Linoleic acid metabolism_Homo sapiens_hsa005910.35469554
117Rap1 signaling pathway_Homo sapiens_hsa040150.34844827
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33120594

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