FNIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the folliculin-interacting protein family. The encoded protein binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK) and be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This protein may also play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. A homologous binding partner of this protein, folliculin-interacting protein 1, has similar binding activities and may suggest functional redundancy within this protein family. Both folliculin-interacting proteins have also been shown to bind the molecular chaperone heat shock protein-90 (Hsp90) and they may function as a co-chaperones in the stabilization of tumor suppressor folliculin which is a target of Hsp90 chaperone activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)6.20426066
2modulation by symbiont of host defense response (GO:0052031)6.20426066
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.20426066
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.20426066
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.20426066
6modulation by symbiont of host immune response (GO:0052553)6.20426066
7neutrophil mediated immunity (GO:0002446)5.28252384
8neutrophil activation involved in immune response (GO:0002283)5.28070061
9regulation of interferon-beta biosynthetic process (GO:0045357)5.08102192
10natural killer cell mediated immunity (GO:0002228)4.95961004
11natural killer cell mediated cytotoxicity (GO:0042267)4.95961004
12regulation of vitamin D biosynthetic process (GO:0060556)4.89236433
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.69465876
14macroautophagy (GO:0016236)4.59877643
15oligosaccharide catabolic process (GO:0009313)4.56654795
16phospholipid homeostasis (GO:0055091)4.50646002
17regulation of fever generation (GO:0031620)4.49457723
18glycosphingolipid catabolic process (GO:0046479)4.40125323
19macrophage activation involved in immune response (GO:0002281)4.34392600
20cellular response to thyroid hormone stimulus (GO:0097067)4.33905516
21regulation of mononuclear cell migration (GO:0071675)4.12670917
22positive regulation of p38MAPK cascade (GO:1900745)4.00844726
23glycolipid catabolic process (GO:0019377)4.00347495
24I-kappaB phosphorylation (GO:0007252)3.94307253
25positive regulation of chemokine biosynthetic process (GO:0045080)3.94206694
26negative regulation of interleukin-12 production (GO:0032695)3.91218292
27response to host immune response (GO:0052572)3.89795439
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.89795439
29regulation of vitamin metabolic process (GO:0030656)3.88616840
30regulation of cytokine secretion involved in immune response (GO:0002739)3.85694708
31L-alpha-amino acid transmembrane transport (GO:1902475)3.84979878
32pinocytosis (GO:0006907)3.83818645
33myeloid leukocyte mediated immunity (GO:0002444)3.81350875
34lipoprotein transport (GO:0042953)3.78737311
35negative regulation of lipid storage (GO:0010888)3.72062609
36regulation of integrin activation (GO:0033623)3.67979704
37negative regulation of cell killing (GO:0031342)3.67265591
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.67265591
39positive regulation of interferon-alpha production (GO:0032727)3.66864538
40regulation of chronic inflammatory response (GO:0002676)3.66371107
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65452405
42ceramide catabolic process (GO:0046514)3.64673521
43positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.64352101
44regulation of heat generation (GO:0031650)3.59652324
45response to muramyl dipeptide (GO:0032495)3.59128901
46regulation of interferon-alpha production (GO:0032647)3.50241348
47regulation of podosome assembly (GO:0071801)3.49748414
48lipopolysaccharide-mediated signaling pathway (GO:0031663)3.45558359
49response to lipoprotein particle (GO:0055094)3.44590954
50neutrophil activation (GO:0042119)3.42593410
51modulation by symbiont of host cellular process (GO:0044068)3.40075740
52positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.40069092
53apoptotic cell clearance (GO:0043277)3.39857344
54basic amino acid transport (GO:0015802)3.37654710
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37197686
56response to host (GO:0075136)3.37197686
57response to host defenses (GO:0052200)3.37197686
58positive regulation of cellular amide metabolic process (GO:0034250)3.37013703
59positive regulation of gamma-delta T cell activation (GO:0046645)3.36810204
60myeloid cell activation involved in immune response (GO:0002275)3.36733893
61germinal center formation (GO:0002467)3.36729361
62granulocyte activation (GO:0036230)3.36140575
63response to peptidoglycan (GO:0032494)3.33485135
64microglial cell activation (GO:0001774)3.30608510
65regulation of T-helper 1 cell differentiation (GO:0045625)3.30174013
66response to thyroid hormone (GO:0097066)3.28214258
67regulation of chemokine biosynthetic process (GO:0045073)3.27968651
68negative regulation of interleukin-1 beta production (GO:0032691)3.27727363
69histone H3-K4 trimethylation (GO:0080182)3.26548963
70regulation of interleukin-8 biosynthetic process (GO:0045414)3.26473145
71cell adhesion mediated by integrin (GO:0033627)3.23716149
72negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.22980904
73membrane lipid catabolic process (GO:0046466)3.18812343
74negative regulation of nitric oxide biosynthetic process (GO:0045019)3.18750052
75positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.18122503
76monocyte chemotaxis (GO:0002548)3.16774168
77branching involved in labyrinthine layer morphogenesis (GO:0060670)3.11489680
78early endosome to late endosome transport (GO:0045022)3.11221275
79regulation of nitric oxide biosynthetic process (GO:0045428)3.05607028
80macrophage activation (GO:0042116)3.02603545
81regulation of mast cell degranulation (GO:0043304)3.02196498
82B cell homeostasis (GO:0001782)3.01275952
83positive regulation of nitric oxide biosynthetic process (GO:0045429)3.00878397
84sphingolipid catabolic process (GO:0030149)3.00690682
85positive regulation of leukocyte apoptotic process (GO:2000108)2.99645188
86negative regulation of interleukin-1 production (GO:0032692)2.99514054
87T-helper 1 type immune response (GO:0042088)2.99444640
88positive regulation of antigen processing and presentation (GO:0002579)2.98530379
89leukocyte mediated cytotoxicity (GO:0001909)2.97123291
90adhesion of symbiont to host cell (GO:0044650)2.95967089
91virion attachment to host cell (GO:0019062)2.95967089
92regulation of mast cell activation involved in immune response (GO:0033006)2.93437288
93regulation of B cell receptor signaling pathway (GO:0050855)2.92011959
94modification by symbiont of host morphology or physiology (GO:0044003)2.90629023
95positive regulation of cholesterol efflux (GO:0010875)2.89699904
96negative regulation of mast cell activation (GO:0033004)2.88662088
97regulation of cholesterol storage (GO:0010885)2.84542313
98positive regulation of B cell differentiation (GO:0045579)2.84168320
99eosinophil chemotaxis (GO:0048245)2.83837968
100developmental pigmentation (GO:0048066)2.83789254
101positive regulation of heat generation (GO:0031652)2.83409414
102regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82212535
103positive regulation of lipid storage (GO:0010884)2.81740831
104negative regulation of granulocyte differentiation (GO:0030853)2.81582902
105osteoclast differentiation (GO:0030316)2.80668506
106regulation of membrane protein ectodomain proteolysis (GO:0051043)2.79952647
107cytidine deamination (GO:0009972)2.79556900
108cytidine metabolic process (GO:0046087)2.79556900
109cytidine catabolic process (GO:0006216)2.79556900
110tryptophan catabolic process (GO:0006569)2.79073930
111indole-containing compound catabolic process (GO:0042436)2.79073930
112indolalkylamine catabolic process (GO:0046218)2.79073930
113cellular response to ethanol (GO:0071361)2.78948563
114negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.77651689
115ovulation from ovarian follicle (GO:0001542)2.77396210
116leukocyte migration involved in inflammatory response (GO:0002523)2.77052894
117positive regulation of lymphocyte apoptotic process (GO:0070230)2.75648197
118viral entry into host cell (GO:0046718)2.75273179
119regulation of heterotypic cell-cell adhesion (GO:0034114)2.75257105
120G-protein coupled receptor internalization (GO:0002031)2.73602638
121wound healing, spreading of epidermal cells (GO:0035313)2.71980802
122regulation of leukocyte degranulation (GO:0043300)2.71065401
123respiratory burst (GO:0045730)2.70260595
124positive regulation of interferon-beta production (GO:0032728)2.68026429
125negative regulation of interleukin-6 production (GO:0032715)2.67981610
126myeloid dendritic cell differentiation (GO:0043011)2.67118939
127regulation of mast cell activation (GO:0033003)2.66905948
128sarcoplasmic reticulum calcium ion transport (GO:0070296)2.66835687
129positive regulation of insulin receptor signaling pathway (GO:0046628)2.66821849
130regulation of lipid storage (GO:0010883)2.65380664
131nerve growth factor signaling pathway (GO:0038180)2.64858184
132cellular response to lipopolysaccharide (GO:0071222)2.64829407
133autophagic vacuole fusion (GO:0000046)2.64808593
134immunoglobulin mediated immune response (GO:0016064)2.62805529
135positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.62604562
136regulation of sequestering of triglyceride (GO:0010889)2.62330161
137negative regulation of translation, ncRNA-mediated (GO:0040033)2.61434881
138regulation of translation, ncRNA-mediated (GO:0045974)2.61434881
139negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61434881
140mannose metabolic process (GO:0006013)2.61285436
141regulation of alkaline phosphatase activity (GO:0010692)2.61009558
142adhesion of symbiont to host (GO:0044406)2.60309378
143low-density lipoprotein particle clearance (GO:0034383)2.58941172
144regulation of protein polyubiquitination (GO:1902914)2.58587919
145positive regulation of T cell apoptotic process (GO:0070234)2.58300227
146positive regulation of interleukin-6 production (GO:0032755)2.57599350
147positive regulation of cholesterol transport (GO:0032376)2.57199257
148positive regulation of sterol transport (GO:0032373)2.57199257
149positive regulation of acute inflammatory response (GO:0002675)2.57172351
150negative regulation of amino acid transport (GO:0051956)2.56385466
151positive regulation of phagocytosis (GO:0050766)2.56169760
152cellular response to molecule of bacterial origin (GO:0071219)2.54775310
153response to nerve growth factor (GO:1990089)2.54410726
154cellular response to nerve growth factor stimulus (GO:1990090)2.54410726
155lysosome organization (GO:0007040)2.54395937
156amino sugar catabolic process (GO:0046348)2.53999534
157interferon-gamma-mediated signaling pathway (GO:0060333)2.53919417
158positive regulation of NF-kappaB import into nucleus (GO:0042346)2.52139460
159regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.52066740
160detection of molecule of bacterial origin (GO:0032490)2.49529946
161regulation of immunoglobulin secretion (GO:0051023)2.48481584
162ovulation (GO:0030728)2.48039103
163eosinophil migration (GO:0072677)2.47854507
164positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47300526
165negative regulation of cytokine production involved in immune response (GO:0002719)2.47286104
166positive regulation of toll-like receptor signaling pathway (GO:0034123)2.45139646
167kynurenine metabolic process (GO:0070189)2.45026246
168regulation of macrophage chemotaxis (GO:0010758)2.43957317
169negative regulation of systemic arterial blood pressure (GO:0003085)2.42534222
170fat-soluble vitamin biosynthetic process (GO:0042362)2.41914581
171positive regulation of type 2 immune response (GO:0002830)2.41338770
172lipid storage (GO:0019915)2.38309214
173regulation of NF-kappaB import into nucleus (GO:0042345)2.34859783
174cellular response to nicotine (GO:0071316)2.34678756
175positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.34380704
176vitamin D metabolic process (GO:0042359)2.34029459
177positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.32980957
178regulation of T-helper 2 cell differentiation (GO:0045628)2.32901631
179regulation of interleukin-12 production (GO:0032655)2.31817431
180keratan sulfate catabolic process (GO:0042340)2.31498491
181cellular response to arsenic-containing substance (GO:0071243)2.30340426
182regulation of macrophage derived foam cell differentiation (GO:0010743)2.28884232
183plasma lipoprotein particle clearance (GO:0034381)2.28210410
184regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.28016565
185sphingosine metabolic process (GO:0006670)2.27295290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse5.02695645
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.62329551
3* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.40712885
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.35404031
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.85340484
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.70539748
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45112302
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.70032074
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63358274
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50247147
11SCL_19346495_ChIP-Seq_HPC-7_Human2.44821673
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39496987
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.32052830
14SPI1_23127762_ChIP-Seq_K562_Human2.27350311
15VDR_24787735_ChIP-Seq_THP-1_Human2.12821437
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12006108
17PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.04662811
18PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.97890498
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.95636434
20* LXR_22158963_ChIP-Seq_LIVER_Mouse1.94617981
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93485081
22* GATA2_21666600_ChIP-Seq_HMVEC_Human1.92674664
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92048982
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91546359
25PU_27001747_Chip-Seq_BMDM_Mouse1.87910719
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.80104230
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78307739
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74946118
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69519242
30* RXR_22158963_ChIP-Seq_LIVER_Mouse1.60757419
31GATA1_22025678_ChIP-Seq_K562_Human1.58018707
32TFEB_21752829_ChIP-Seq_HELA_Human1.56133281
33EZH2_22144423_ChIP-Seq_EOC_Human1.54723016
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53268160
35NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48205781
36VDR_24763502_ChIP-Seq_THP-1_Human1.46915043
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.46246519
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45427978
39* FOXO3_23340844_ChIP-Seq_DLD1_Human1.43531747
40GBX2_23144817_ChIP-Seq_PC3_Human1.40181063
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38065470
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.37250236
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37045710
44SPI1_23547873_ChIP-Seq_NB4_Human1.37007375
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36209516
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36185767
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35509318
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32429785
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31338185
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25616601
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25081025
52* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24482471
53* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24374158
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24234414
55* FOXA2_19822575_ChIP-Seq_HepG2_Human1.22669553
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21531448
57* RUNX1_22412390_ChIP-Seq_EML_Mouse1.21168989
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19864066
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19686307
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.19533505
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19040168
62VDR_21846776_ChIP-Seq_THP-1_Human1.18044329
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.14254169
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13782908
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12774062
66TP53_16413492_ChIP-PET_HCT116_Human1.12183267
67* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11385380
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10906814
69GATA1_19941826_ChIP-Seq_K562_Human1.10530647
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10329120
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08635418
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08519956
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08009086
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08009086
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07976105
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07976105
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.07359552
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06168445
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06168445
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05722525
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.05284468
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05091578
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.04893317
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04345585
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04318288
86AHR_22903824_ChIP-Seq_MCF-7_Human1.04228388
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04040259
88GATA2_19941826_ChIP-Seq_K562_Human1.02838385
89* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02468773
90* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02078370
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01703742
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00933064
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00489091
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99666833
95TCF7_22412390_ChIP-Seq_EML_Mouse0.99509854
96SMAD4_21799915_ChIP-Seq_A2780_Human0.98914156
97* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98426620
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97489076
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96912782
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96682574
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96137505
102BRD4_25478319_ChIP-Seq_HGPS_Human0.95681430
103TAF15_26573619_Chip-Seq_HEK293_Human0.95266842
104NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94765177
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94099673
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91774024
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91640760
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.91282959
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91154129
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91141006
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90570428
112* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90304501
113MYB_26560356_Chip-Seq_TH1_Human0.90282420
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89693416
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89679447
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89641709
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89589919
118FOXM1_23109430_ChIP-Seq_U2OS_Human0.89086019
119AR_25329375_ChIP-Seq_VCAP_Human0.88771389
120* E2F1_18555785_Chip-Seq_ESCs_Mouse0.88690780
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88556356
122PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88324432
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.88172449
124RUNX_20019798_ChIP-Seq_JUKART_Human0.87856698
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87472588
126P300_19829295_ChIP-Seq_ESCs_Human0.87345358
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87097669
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86834600
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86825528
130* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86500210
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86466210
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.85791737
133* TP63_23658742_ChIP-Seq_EP156T_Human0.85319737
134MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85251678
135* CMYC_18555785_Chip-Seq_ESCs_Mouse0.84702721
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.84557896
137GATA6_25053715_ChIP-Seq_YYC3_Human0.84338839
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.84214653
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83067559
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83060171
141GF1_26923725_Chip-Seq_HPCs_Mouse0.83054897
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82265821
143* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82086896
144CJUN_26792858_Chip-Seq_BT549_Human0.81807038
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81638077
146IGF1R_20145208_ChIP-Seq_DFB_Human0.80416999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.68588412
2MP0003172_abnormal_lysosome_physiology4.53092680
3MP0005174_abnormal_tail_pigmentation3.81155412
4MP0000015_abnormal_ear_pigmentation3.15842372
5MP0005257_abnormal_intraocular_pressure2.67972374
6MP0000371_diluted_coat_color2.27049087
7MP0002419_abnormal_innate_immunity2.15995185
8MP0003075_altered_response_to2.15181779
9MP0009840_abnormal_foam_cell2.13575823
10MP0009278_abnormal_bone_marrow2.13475101
11MP0005451_abnormal_body_composition2.12435419
12MP0001835_abnormal_antigen_presentation2.12090399
13MP0003183_abnormal_peptide_metabolism2.06765691
14MP0003646_muscle_fatigue2.06055830
15MP0000343_altered_response_to2.05495537
16MP0006082_CNS_inflammation2.04999116
17MP0008004_abnormal_stomach_pH2.04068088
18MP0004510_myositis2.01888484
19MP0000569_abnormal_digit_pigmentation10.0925467
20MP0003303_peritoneal_inflammation1.97965567
21MP0003436_decreased_susceptibility_to1.97668851
22MP0005464_abnormal_platelet_physiology1.94583364
23MP0001958_emphysema1.92229352
24MP0003300_gastrointestinal_ulcer1.92166316
25MP0004381_abnormal_hair_follicle1.84285366
26MP0010307_abnormal_tumor_latency1.76873029
27MP0003690_abnormal_glial_cell1.68323015
28MP0005671_abnormal_response_to1.64867570
29MP0006054_spinal_hemorrhage1.62523753
30MP0003566_abnormal_cell_adhesion1.58603602
31MP0001501_abnormal_sleep_pattern1.53842927
32MP0005076_abnormal_cell_differentiation1.52404281
33MP0002139_abnormal_hepatobiliary_system1.49586004
34MP0005408_hypopigmentation1.49549593
35MP0000920_abnormal_myelination1.48773561
36MP0002166_altered_tumor_susceptibility1.47703110
37MP0005647_abnormal_sex_gland1.44931662
38MP0003191_abnormal_cellular_cholesterol1.41350548
39MP0002452_abnormal_antigen_presenting1.39614727
40MP0002837_dystrophic_cardiac_calcinosis1.39293763
41MP0005083_abnormal_biliary_tract1.38340187
42MP0005310_abnormal_salivary_gland1.36441495
43MP0005000_abnormal_immune_tolerance1.35636746
44MP0008260_abnormal_autophagy1.34364853
45MP0004947_skin_inflammation1.34051471
46MP0000604_amyloidosis1.34011422
47MP0003329_amyloid_beta_deposits1.30368310
48MP0005025_abnormal_response_to1.29873897
49MP0005166_decreased_susceptibility_to1.29787963
50MP0005360_urolithiasis1.28028321
51MP0003448_altered_tumor_morphology1.25559070
52MP0005075_abnormal_melanosome_morpholog1.23902011
53MP0001790_abnormal_immune_system1.23324298
54MP0005387_immune_system_phenotype1.23324298
55MP0001800_abnormal_humoral_immune1.21488855
56MP0002723_abnormal_immune_serum1.20935967
57MP0002090_abnormal_vision1.14099341
58MP0003633_abnormal_nervous_system1.12235087
59MP0005164_abnormal_response_to1.12047537
60MP0001324_abnormal_eye_pigmentation1.09497537
61MP0002998_abnormal_bone_remodeling1.09465218
62MP0003252_abnormal_bile_duct1.09208862
63MP0003195_calcinosis1.04832470
64MP0005197_abnormal_uvea_morphology1.03795636
65MP0003879_abnormal_hair_cell1.01010279
66MP0005165_increased_susceptibility_to1.00623369
67MP0001819_abnormal_immune_cell1.00309144
68MP0002006_tumorigenesis0.99419534
69MP0002075_abnormal_coat/hair_pigmentati0.99151526
70MP0003656_abnormal_erythrocyte_physiolo0.98750910
71MP0001533_abnormal_skeleton_physiology0.98589774
72MP0002420_abnormal_adaptive_immunity0.98114552
73MP0003705_abnormal_hypodermis_morpholog0.96702389
74MP0005167_abnormal_blood-brain_barrier0.95624182
75MP0008469_abnormal_protein_level0.93174734
76MP0003091_abnormal_cell_migration0.91531069
77MP0002928_abnormal_bile_duct0.91389068
78MP0005365_abnormal_bile_salt0.91339425
79MP0004043_abnormal_pH_regulation0.90409096
80MP0010155_abnormal_intestine_physiology0.89053321
81MP0000465_gastrointestinal_hemorrhage0.87866032
82MP0002095_abnormal_skin_pigmentation0.87374518
83MP0002138_abnormal_hepatobiliary_system0.87222699
84MP0005535_abnormal_body_temperature0.86478921
85MP0002254_reproductive_system_inflammat0.86379648
86MP0009046_muscle_twitch0.85633836
87MP0003453_abnormal_keratinocyte_physiol0.85411415
88MP0002405_respiratory_system_inflammati0.85073682
89MP0009763_increased_sensitivity_to0.81629399
90MP0005595_abnormal_vascular_smooth0.81483730
91MP0001845_abnormal_inflammatory_respons0.81469465
92MP0002148_abnormal_hypersensitivity_rea0.79364961
93MP0003631_nervous_system_phenotype0.78836995
94MP0005397_hematopoietic_system_phenotyp0.78602472
95MP0001545_abnormal_hematopoietic_system0.78602472
96MP0010352_gastrointestinal_tract_polyps0.78336892
97MP0001915_intracranial_hemorrhage0.77859424
98MP0001851_eye_inflammation0.77800962
99MP0000685_abnormal_immune_system0.77578257
100MP0003634_abnormal_glial_cell0.77399706
101MP0000609_abnormal_liver_physiology0.76594225
102MP0000858_altered_metastatic_potential0.76142664
103MP0000689_abnormal_spleen_morphology0.75945063
104MP0001186_pigmentation_phenotype0.75372430
105MP0002877_abnormal_melanocyte_morpholog0.74831307
106MP0002118_abnormal_lipid_homeostasis0.74191126
107MP0002332_abnormal_exercise_endurance0.73747470
108MP0010386_abnormal_urinary_bladder0.73488428
109MP0001542_abnormal_bone_strength0.73176573
110MP0009115_abnormal_fat_cell0.72702930
111MP0001243_abnormal_dermal_layer0.72054330
112MP0008438_abnormal_cutaneous_collagen0.71768330
113MP0002168_other_aberrant_phenotype0.71452024
114MP0005448_abnormal_energy_balance0.69959274
115MP0000767_abnormal_smooth_muscle0.69815956
116MP0003950_abnormal_plasma_membrane0.68035826
117MP0003632_abnormal_nervous_system0.67934209
118MP0005334_abnormal_fat_pad0.67796360
119MP0002693_abnormal_pancreas_physiology0.67077236
120MP0005410_abnormal_fertilization0.66072476
121MP0003724_increased_susceptibility_to0.65533481
122MP0003828_pulmonary_edema0.64926940
123MP0009764_decreased_sensitivity_to0.64832526
124MP0002396_abnormal_hematopoietic_system0.64671357
125MP0009785_altered_susceptibility_to0.64601764
126MP0001853_heart_inflammation0.62632712
127MP0005621_abnormal_cell_physiology0.62576083
128MP0000716_abnormal_immune_system0.61963173
129MP0008874_decreased_physiological_sensi0.61582365
130MP0002060_abnormal_skin_morphology0.61465621
131MP0002933_joint_inflammation0.61433293
132MP0008875_abnormal_xenobiotic_pharmacok0.61135068
133MP0004883_abnormal_blood_vessel0.60755556
134MP0003045_fibrosis0.60483378
135MP0010329_abnormal_lipoprotein_level0.60405224
136MP0000383_abnormal_hair_follicle0.59283759
137MP0005266_abnormal_metabolism0.58906100
138MP0000249_abnormal_blood_vessel0.58675712
139MP0001873_stomach_inflammation0.58415646
140MP0005171_absent_coat_pigmentation0.58129905
141MP0005666_abnormal_adipose_tissue0.58126662
142MP0001727_abnormal_embryo_implantation0.57712182

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.79523715
2Recurrent bacterial skin infections (HP:0005406)5.64789108
3Increased cerebral lipofuscin (HP:0011813)5.08218847
4Vacuolated lymphocytes (HP:0001922)4.61227725
5Neurofibrillary tangles (HP:0002185)4.27469830
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.24790366
7Mutism (HP:0002300)4.07231021
8Abnormality of glycolipid metabolism (HP:0010969)3.89502757
9Abnormality of liposaccharide metabolism (HP:0010968)3.89502757
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.89502757
11Gingivitis (HP:0000230)3.85896957
12Axonal loss (HP:0003447)3.72596715
13Abnormality of macrophages (HP:0004311)3.71770305
14Prostate neoplasm (HP:0100787)3.62133515
15Recurrent gram-negative bacterial infections (HP:0005420)3.61951464
16Periodontitis (HP:0000704)3.48985255
17Eczematoid dermatitis (HP:0000976)3.47580337
18Abnormality of polysaccharide metabolism (HP:0011012)3.30190517
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.30190517
20Abnormality of mucopolysaccharide metabolism (HP:0011020)3.30190517
21Retrobulbar optic neuritis (HP:0100654)3.28620735
22Optic neuritis (HP:0100653)3.28620735
23Dysostosis multiplex (HP:0000943)3.28469329
24Disinhibition (HP:0000734)3.28402149
25Nuclear cataract (HP:0100018)3.27012264
26Asymmetric septal hypertrophy (HP:0001670)3.24577159
27Thick nail (HP:0001805)3.14667539
28Pathologic fracture (HP:0002756)3.14345163
29Recurrent skin infections (HP:0001581)3.14329732
30Cerebral inclusion bodies (HP:0100314)3.14010057
31Apathy (HP:0000741)3.13605323
32Stomatitis (HP:0010280)3.04549370
33Premature loss of primary teeth (HP:0006323)3.04325961
34Myocardial infarction (HP:0001658)3.01847057
35Complement deficiency (HP:0004431)3.00984924
36Orchitis (HP:0100796)2.99570997
37Global brain atrophy (HP:0002283)2.99493925
38Diminished motivation (HP:0000745)2.97659216
39Metaphyseal irregularity (HP:0003025)2.97164402
40Mucopolysacchariduria (HP:0008155)2.94795368
41Urinary glycosaminoglycan excretion (HP:0003541)2.94795368
42Submucous cleft hard palate (HP:0000176)2.94736261
43Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.83012015
44Joint hemorrhage (HP:0005261)2.81048889
45Autoimmune thrombocytopenia (HP:0001973)2.81030497
46Peripheral demyelination (HP:0011096)2.79434360
47Gingival bleeding (HP:0000225)2.79050512
48Distal lower limb amyotrophy (HP:0008944)2.66981140
49Upper motor neuron abnormality (HP:0002127)2.63591606
50Bone pain (HP:0002653)2.59505488
51Loss of speech (HP:0002371)2.59308706
52Absent frontal sinuses (HP:0002688)2.56406468
53Tetany (HP:0001281)2.51954713
54Generalized hypopigmentation (HP:0007513)2.48770864
55Abnormality of the periventricular white matter (HP:0002518)2.45010769
56Aplasia/Hypoplasia of the macula (HP:0008059)2.44964829
57Hypophosphatemia (HP:0002148)2.44311383
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.42940209
59Hypercholesterolemia (HP:0003124)2.40290707
60Basal ganglia calcification (HP:0002135)2.39029395
61Amyloidosis (HP:0011034)2.36387816
62Urethral obstruction (HP:0000796)2.36381883
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31484148
64Ocular albinism (HP:0001107)2.30992920
65Abnormality of vision evoked potentials (HP:0000649)2.30850116
66Increased CSF protein (HP:0002922)2.29947598
67Interstitial pulmonary disease (HP:0006530)2.28912983
68Abnormality of the fingertips (HP:0001211)2.27819608
69Dementia (HP:0000726)2.27605852
70Nausea (HP:0002018)2.27062277
71Myositis (HP:0100614)2.26704651
72Progressive neurologic deterioration (HP:0002344)2.25079374
73Neurodegeneration (HP:0002180)2.24467706
74Large earlobe (HP:0009748)2.23875836
75Hematochezia (HP:0002573)2.23187752
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22789312
77Neuronal loss in central nervous system (HP:0002529)2.22585652
78Chromsome breakage (HP:0040012)2.22138139
79Keratoconjunctivitis sicca (HP:0001097)2.21430630
80Aplasia/Hypoplasia affecting the retina (HP:0008061)2.17336071
81Intrahepatic cholestasis (HP:0001406)2.17331484
82Thoracic kyphosis (HP:0002942)2.17310229
83Upper limb muscle weakness (HP:0003484)2.16152278
84Mediastinal lymphadenopathy (HP:0100721)2.14963478
85Retinal atrophy (HP:0001105)2.12947044
86Slow saccadic eye movements (HP:0000514)2.12227171
87Protuberant abdomen (HP:0001538)2.09786822
88Osteomyelitis (HP:0002754)2.09442070
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09330044
90Abnormality of complement system (HP:0005339)2.08999358
91Recurrent fungal infections (HP:0002841)2.08530796
92Turricephaly (HP:0000262)2.08127845
93Skin nodule (HP:0200036)2.07353333
94Purpura (HP:0000979)2.04965889
95Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04597781
96Keratoconjunctivitis (HP:0001096)2.03076671
97Bruising susceptibility (HP:0000978)2.01638909
98Abnormality of the thoracic spine (HP:0100711)2.00967233
99Conjunctival telangiectasia (HP:0000524)1.99370985
100Lower limb amyotrophy (HP:0007210)1.99255283
101Systemic lupus erythematosus (HP:0002725)1.98893593
102Xanthomatosis (HP:0000991)1.98005800
103Frequent falls (HP:0002359)1.97599126
104Pulmonary infiltrates (HP:0002113)1.95081064
105Distal lower limb muscle weakness (HP:0009053)1.92564990
106Elevated erythrocyte sedimentation rate (HP:0003565)1.92362948
107Polyneuropathy (HP:0001271)1.90669819
108Elevated alkaline phosphatase (HP:0003155)1.89192842
109Reticulocytosis (HP:0001923)1.88709153
110Supranuclear gaze palsy (HP:0000605)1.88367358
111Steatorrhea (HP:0002570)1.88229348
112Epidermoid cyst (HP:0200040)1.87934261
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.86935801
114Osteolytic defects of the hand bones (HP:0009699)1.86935801
115Pulmonary artery stenosis (HP:0004415)1.86139387
116Prolonged neonatal jaundice (HP:0006579)1.85441890
117Inappropriate behavior (HP:0000719)1.85276221
118Gangrene (HP:0100758)1.84798205
119Abnormality of the lumbar spine (HP:0100712)1.84157719
120Albinism (HP:0001022)1.83611718
121Abnormality of the frontal sinuses (HP:0002687)1.82945590
122Chronic obstructive pulmonary disease (HP:0006510)1.82304689
123Obstructive lung disease (HP:0006536)1.82304689
124Sensorimotor neuropathy (HP:0007141)1.81621087
125Abnormality of primary teeth (HP:0006481)1.81007819
126Cardiomegaly (HP:0001640)1.80455727
127Agnosia (HP:0010524)1.79208141
128Ovoid vertebral bodies (HP:0003300)1.78824910
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78382999
130Long toe (HP:0010511)1.77799265
131Zonular cataract (HP:0010920)1.77461555
132Impaired platelet aggregation (HP:0003540)1.76672284
133Abnormal platelet function (HP:0011869)1.76672284
134Abnormality of the basal ganglia (HP:0002134)1.76175844
135Glomerulonephritis (HP:0000099)1.76010538
136Epistaxis (HP:0000421)1.75034091
137Hyperventilation (HP:0002883)1.74333998
138Esophageal varix (HP:0002040)1.74040583
139Hepatosplenomegaly (HP:0001433)1.73938945
140Iris hypopigmentation (HP:0007730)1.73877329
141Increased serum ferritin (HP:0003281)1.73090194
142Tetraparesis (HP:0002273)1.73063776
143Menorrhagia (HP:0000132)1.73009081
144Memory impairment (HP:0002354)1.72634762
145Parakeratosis (HP:0001036)1.72346572
146Progressive hearing impairment (HP:0001730)1.71670410
147Ectopic kidney (HP:0000086)1.71664151
148Acne (HP:0001061)1.69624682
149Hemoptysis (HP:0002105)1.69154551
150Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68197716
151Malnutrition (HP:0004395)1.66925770
152Vertigo (HP:0002321)1.66895949
153Nephritis (HP:0000123)1.66694885
154Joint swelling (HP:0001386)1.65799929
155Bundle branch block (HP:0011710)1.64987276
156Action tremor (HP:0002345)1.62674403
157Postural tremor (HP:0002174)1.61825649
158Fat malabsorption (HP:0002630)1.57441165

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.15587472
2GRK73.66849877
3IRAK33.53037882
4DDR23.45672315
5KIT3.25545071
6MAP3K143.23710529
7CDK123.21659111
8CAMK1D3.16803401
9ACVR1B2.91736376
10CAMK1G2.86056472
11RIPK42.45479982
12IRAK42.42331285
13MATK2.36612695
14TTN2.22460606
15TAOK12.11971167
16SIK22.09579323
17BRD42.07673473
18TAOK22.01859089
19TYK21.90058208
20ADRBK21.88275385
21TBK11.84436910
22MAP3K131.75668071
23PTK61.73545325
24BMPR21.68430406
25IKBKB1.63105761
26MOS1.63064824
27CDK61.53895828
28IKBKE1.52302554
29CDC42BPA1.50475684
30JAK11.47733000
31FES1.44027243
32FRK1.40691263
33INSRR1.38512012
34HCK1.38225419
35CSF1R1.37941910
36BLK1.36919853
37PKN11.33379685
38EPHB11.31652882
39CHUK1.31218852
40FGR1.30055963
41LATS21.20579651
42TRPM71.19153518
43IRAK11.17670988
44TGFBR21.17018604
45JAK31.14237064
46STK241.11545095
47AKT31.10106481
48DAPK21.09891449
49EPHA31.09870085
50MAP3K111.09790823
51TYRO31.09693145
52CSK1.09516543
53ICK1.09383810
54NME21.07670715
55PIM21.06763882
56SGK21.05582973
57SGK31.05016130
58NEK91.02564934
59IRAK21.02463091
60MAP3K51.01928788
61STK40.99971429
62MTOR0.97474318
63MAP3K10.96956258
64FGFR30.89581926
65RIPK10.87695190
66STK30.87683522
67EGFR0.86702986
68MAPK70.85293349
69JAK20.84116119
70PBK0.83928754
71LCK0.83762033
72SGK10.83653813
73PDGFRB0.83085931
74NTRK30.82086900
75YES10.81476651
76MARK30.79487845
77PTK20.79138695
78OBSCN0.78834207
79ABL10.78197207
80MAP3K90.77117825
81WNK10.74546030
82MAP3K30.74011723
83MAP2K60.72997049
84PDGFRA0.71582058
85MAP3K20.70502804
86CLK10.70039557
87LYN0.68255584
88SYK0.66003665
89PIM10.65380584
90EIF2AK20.65277325
91MAPK120.65124683
92ZAP700.65072109
93ERN10.65057112
94SCYL20.63852652
95MAPK40.62976294
96MAP3K100.62164640
97MARK10.62119686
98CAMKK20.61239029
99MAPK100.60826773
100DYRK30.59900610
101ERBB20.59751599
102GSK3A0.59700593
103PDK20.58730252
104TXK0.57326680
105MAP4K10.57183175
106PRPF4B0.55975308
107SGK2230.55750608
108SGK4940.55750608
109MAP2K30.54667516
110PRKAA20.53942637
111HIPK20.53243941
112ZAK0.52897369
113PDK10.51568019
114TNIK0.49816610
115FYN0.49584835
116KSR10.46516426
117FER0.46146149
118RPS6KA20.45397278
119PDPK10.45327408
120MELK0.43271997
121MET0.42227376
122SIK10.42044734
123KSR20.41927494
124LATS10.41764664
125CDK90.40594972
126NLK0.40578826
127CAMK40.39993415
128CASK0.39186406
129ITK0.39025195
130ERBB40.38254524
131AKT10.38164816
132CSNK1A1L0.37758517
133BMX0.36702064
134INSR0.36270883
135NUAK10.34925208
136SRC0.33843355
137ATR0.33558832
138MARK20.33013719
139ATM0.32475551
140FLT30.31772118
141RPS6KL10.31616897
142RPS6KC10.31616897
143MAPK10.31475874
144ABL20.31052890
145PRKACG0.30976635
146PAK40.30914285
147PRKG10.30619712

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.34167195
2Lysosome_Homo sapiens_hsa041423.04809137
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.04357094
4Staphylococcus aureus infection_Homo sapiens_hsa051502.67586309
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.65869312
6Other glycan degradation_Homo sapiens_hsa005112.19854860
7Osteoclast differentiation_Homo sapiens_hsa043802.10754560
8Lysine degradation_Homo sapiens_hsa003101.96572440
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.88253291
10Leishmaniasis_Homo sapiens_hsa051401.84518566
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83383715
12Tuberculosis_Homo sapiens_hsa051521.76876573
13Malaria_Homo sapiens_hsa051441.75971342
14Phagosome_Homo sapiens_hsa041451.73925365
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72554145
16Collecting duct acid secretion_Homo sapiens_hsa049661.70752047
17Complement and coagulation cascades_Homo sapiens_hsa046101.58268798
18B cell receptor signaling pathway_Homo sapiens_hsa046621.55472142
19Rheumatoid arthritis_Homo sapiens_hsa053231.52240924
20Type II diabetes mellitus_Homo sapiens_hsa049301.50015013
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.45239505
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40896535
23Type I diabetes mellitus_Homo sapiens_hsa049401.40018308
24Steroid biosynthesis_Homo sapiens_hsa001001.34035187
25ABC transporters_Homo sapiens_hsa020101.30100743
26Pertussis_Homo sapiens_hsa051331.24688654
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24140661
28Measles_Homo sapiens_hsa051621.22447906
29Autoimmune thyroid disease_Homo sapiens_hsa053201.20990160
30Apoptosis_Homo sapiens_hsa042101.19370829
31Sphingolipid metabolism_Homo sapiens_hsa006001.18468511
32Influenza A_Homo sapiens_hsa051641.18360364
33Prion diseases_Homo sapiens_hsa050201.17675726
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17536505
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16988717
36Chronic myeloid leukemia_Homo sapiens_hsa052201.14528281
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11840216
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04743498
39TNF signaling pathway_Homo sapiens_hsa046681.03136897
40Hepatitis C_Homo sapiens_hsa051600.98550694
41Toxoplasmosis_Homo sapiens_hsa051450.97456996
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97298850
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97045143
44Prolactin signaling pathway_Homo sapiens_hsa049170.93730174
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92982342
46Tryptophan metabolism_Homo sapiens_hsa003800.90466642
47MicroRNAs in cancer_Homo sapiens_hsa052060.90336888
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89300617
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87495502
50Chemokine signaling pathway_Homo sapiens_hsa040620.85547951
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83098688
52Inositol phosphate metabolism_Homo sapiens_hsa005620.82403180
53Starch and sucrose metabolism_Homo sapiens_hsa005000.81337945
54Pancreatic cancer_Homo sapiens_hsa052120.81232983
55Fatty acid biosynthesis_Homo sapiens_hsa000610.80768192
56Insulin resistance_Homo sapiens_hsa049310.80544788
57Small cell lung cancer_Homo sapiens_hsa052220.80390629
58One carbon pool by folate_Homo sapiens_hsa006700.77602046
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.76338378
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76017686
61Acute myeloid leukemia_Homo sapiens_hsa052210.74699194
62Legionellosis_Homo sapiens_hsa051340.74636516
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73588788
64Circadian rhythm_Homo sapiens_hsa047100.73231865
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69425655
66Sulfur metabolism_Homo sapiens_hsa009200.68442577
67Dorso-ventral axis formation_Homo sapiens_hsa043200.68398959
68Amoebiasis_Homo sapiens_hsa051460.67642263
69Hematopoietic cell lineage_Homo sapiens_hsa046400.67436843
70Salmonella infection_Homo sapiens_hsa051320.66335379
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65986677
72Vibrio cholerae infection_Homo sapiens_hsa051100.65807509
73Selenocompound metabolism_Homo sapiens_hsa004500.65202428
74mTOR signaling pathway_Homo sapiens_hsa041500.64835785
75Renin secretion_Homo sapiens_hsa049240.64741142
76Hepatitis B_Homo sapiens_hsa051610.64197102
77PPAR signaling pathway_Homo sapiens_hsa033200.60637371
78Antigen processing and presentation_Homo sapiens_hsa046120.60243014
79Prostate cancer_Homo sapiens_hsa052150.59878893
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.59392133
81Ovarian steroidogenesis_Homo sapiens_hsa049130.58484270
82Notch signaling pathway_Homo sapiens_hsa043300.58304800
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58078007
84Synaptic vesicle cycle_Homo sapiens_hsa047210.57920733
85Proteoglycans in cancer_Homo sapiens_hsa052050.57273227
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.56772171
87Bladder cancer_Homo sapiens_hsa052190.56761417
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.55533817
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.55039987
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.54835081
91T cell receptor signaling pathway_Homo sapiens_hsa046600.54769293
92Viral myocarditis_Homo sapiens_hsa054160.53066605
93Nitrogen metabolism_Homo sapiens_hsa009100.50497001
94Arginine biosynthesis_Homo sapiens_hsa002200.49760764
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49633729
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49207472
97Graft-versus-host disease_Homo sapiens_hsa053320.49159829
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.49016889
99Endocytosis_Homo sapiens_hsa041440.47734825
100Histidine metabolism_Homo sapiens_hsa003400.47495194
101Platelet activation_Homo sapiens_hsa046110.47376201
102Asthma_Homo sapiens_hsa053100.46973754
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.46295946
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45968237
105Herpes simplex infection_Homo sapiens_hsa051680.45948325
106African trypanosomiasis_Homo sapiens_hsa051430.45785956
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.45746510
108Retinol metabolism_Homo sapiens_hsa008300.45402459
109Bile secretion_Homo sapiens_hsa049760.44366988
110Shigellosis_Homo sapiens_hsa051310.44095017
111Melanoma_Homo sapiens_hsa052180.43847375
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42520670
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42429126
114Allograft rejection_Homo sapiens_hsa053300.42227692
115Choline metabolism in cancer_Homo sapiens_hsa052310.41650067
116FoxO signaling pathway_Homo sapiens_hsa040680.41492455
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41469265
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41395878
119GnRH signaling pathway_Homo sapiens_hsa049120.41384717
120VEGF signaling pathway_Homo sapiens_hsa043700.41107082
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40425092
122Mineral absorption_Homo sapiens_hsa049780.40165156
123HIF-1 signaling pathway_Homo sapiens_hsa040660.36013392
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34712767
125Renal cell carcinoma_Homo sapiens_hsa052110.32195659
126MAPK signaling pathway_Homo sapiens_hsa040100.31868675
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30882268
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28473881
129Ether lipid metabolism_Homo sapiens_hsa005650.28055177
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27930891
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27642785
132Oxytocin signaling pathway_Homo sapiens_hsa049210.26020467
133Renin-angiotensin system_Homo sapiens_hsa046140.25178998
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.23898409
135Estrogen signaling pathway_Homo sapiens_hsa049150.22920889
136Insulin signaling pathway_Homo sapiens_hsa049100.22368388

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