FNTA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.62319915
2central nervous system myelination (GO:0022010)6.62319915
3fatty acid elongation (GO:0030497)5.90816654
4monoubiquitinated protein deubiquitination (GO:0035520)5.80934043
5cholesterol biosynthetic process (GO:0006695)5.30631675
6positive regulation of developmental pigmentation (GO:0048087)4.93821212
7L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.87989147
8protein K11-linked deubiquitination (GO:0035871)4.84349219
9establishment of protein localization to Golgi (GO:0072600)4.75894836
10sterol biosynthetic process (GO:0016126)4.72888281
11regulation of pigment cell differentiation (GO:0050932)4.68129783
12viral transcription (GO:0019083)4.49294995
13translational termination (GO:0006415)4.45627625
14histone H3-K4 trimethylation (GO:0080182)4.40688435
15neural tube formation (GO:0001841)4.39872832
16behavioral response to ethanol (GO:0048149)4.38234915
17ensheathment of neurons (GO:0007272)4.37517915
18axon ensheathment (GO:0008366)4.37517915
19snRNA transcription (GO:0009301)4.30446377
20myelination (GO:0042552)4.29157402
21cotranslational protein targeting to membrane (GO:0006613)4.12330742
22mitochondrion distribution (GO:0048311)4.07978299
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.07582161
24protein targeting to ER (GO:0045047)4.06530487
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04506243
26translational elongation (GO:0006414)3.98655685
27ribosomal small subunit biogenesis (GO:0042274)3.98357217
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.96801087
29protein localization to endoplasmic reticulum (GO:0070972)3.93843111
30phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.88384703
31isoprenoid biosynthetic process (GO:0008299)3.88347398
32response to methylmercury (GO:0051597)3.88093189
33interkinetic nuclear migration (GO:0022027)3.87345581
34protein targeting to Golgi (GO:0000042)3.86795102
35ribosomal large subunit biogenesis (GO:0042273)3.76802494
36protein K48-linked deubiquitination (GO:0071108)3.73520629
37long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.69569528
38L-methionine salvage (GO:0071267)3.68947412
39L-methionine biosynthetic process (GO:0071265)3.68947412
40amino acid salvage (GO:0043102)3.68947412
41retrograde transport, vesicle recycling within Golgi (GO:0000301)3.67134788
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66637923
43ATP synthesis coupled proton transport (GO:0015986)3.66637923
44myelin maintenance (GO:0043217)3.65773031
45viral life cycle (GO:0019058)3.64645730
46maturation of SSU-rRNA (GO:0030490)3.62064325
47translational initiation (GO:0006413)3.61195090
48cullin deneddylation (GO:0010388)3.57834615
49microtubule anchoring (GO:0034453)3.53733530
50peptidyl-lysine trimethylation (GO:0018023)3.50733470
51positive regulation of oligodendrocyte differentiation (GO:0048714)3.49776245
52photoreceptor cell maintenance (GO:0045494)3.46485399
53protein deneddylation (GO:0000338)3.46452215
54proteasome assembly (GO:0043248)3.46196298
55detection of light stimulus involved in sensory perception (GO:0050962)3.43756293
56detection of light stimulus involved in visual perception (GO:0050908)3.43756293
57ribosomal small subunit assembly (GO:0000028)3.42564730
58signal peptide processing (GO:0006465)3.39961303
59indolalkylamine metabolic process (GO:0006586)3.39932616
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39506464
61cellular protein complex disassembly (GO:0043624)3.38833987
62indolalkylamine catabolic process (GO:0046218)3.37278609
63tryptophan catabolic process (GO:0006569)3.37278609
64indole-containing compound catabolic process (GO:0042436)3.37278609
65long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.35990587
66cilium or flagellum-dependent cell motility (GO:0001539)3.33571497
67DNA deamination (GO:0045006)3.30642019
68creatine metabolic process (GO:0006600)3.30382144
69cellular response to ethanol (GO:0071361)3.29916749
70fatty-acyl-CoA biosynthetic process (GO:0046949)3.27656612
71substantia nigra development (GO:0021762)3.27480050
72translesion synthesis (GO:0019985)3.26484115
73NADPH regeneration (GO:0006740)3.25003306
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.24741974
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23482134
76negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.23037077
77negative regulation of translation, ncRNA-mediated (GO:0040033)3.23037077
78regulation of translation, ncRNA-mediated (GO:0045974)3.23037077
79cytoplasmic mRNA processing body assembly (GO:0033962)3.19712514
80protein K63-linked deubiquitination (GO:0070536)3.19681726
81regulation of posttranscriptional gene silencing (GO:0060147)3.15290749
82regulation of gene silencing by miRNA (GO:0060964)3.15290749
83regulation of gene silencing by RNA (GO:0060966)3.15290749
84negative regulation of neurotransmitter transport (GO:0051589)3.14503497
85hindbrain development (GO:0030902)3.13600671
86acyl-CoA biosynthetic process (GO:0071616)3.13206191
87thioester biosynthetic process (GO:0035384)3.13206191
88nucleus localization (GO:0051647)3.12753296
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10787788
90negative regulation of ligase activity (GO:0051352)3.10787788
91specification of organ identity (GO:0010092)3.10469532
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10145850
93replication fork processing (GO:0031297)3.09429832
94nuclear envelope reassembly (GO:0031468)3.09335723
95mitotic nuclear envelope reassembly (GO:0007084)3.09335723
96fatty-acyl-CoA metabolic process (GO:0035337)3.08964734
97adaptation of signaling pathway (GO:0023058)3.07416679
98translation (GO:0006412)3.05855535
99fibroblast migration (GO:0010761)3.05500259
100negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.04926778
101regulation of sarcomere organization (GO:0060297)3.04287513
102peptidyl-lysine methylation (GO:0018022)3.03620895
103regulation of collateral sprouting (GO:0048670)3.03026866
104establishment of mitochondrion localization (GO:0051654)3.00932030
105long-chain fatty acid biosynthetic process (GO:0042759)2.98180911
106protein targeting to membrane (GO:0006612)2.97528391
107tryptophan metabolic process (GO:0006568)2.97177847
108* prenylation (GO:0097354)2.95130870
109* protein prenylation (GO:0018342)2.95130870
110histone mRNA catabolic process (GO:0071044)2.94886565
111DNA double-strand break processing (GO:0000729)2.93615950
112establishment of integrated proviral latency (GO:0075713)2.92770385
113polyamine metabolic process (GO:0006595)2.92157969
114regulation of penile erection (GO:0060405)2.91893057
115short-term memory (GO:0007614)2.91327222
116negative regulation of neurotransmitter secretion (GO:0046929)2.90955388
117kynurenine metabolic process (GO:0070189)2.90763389
118protein complex disassembly (GO:0043241)2.90540396
119L-serine metabolic process (GO:0006563)2.88494567
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88440952
121positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.86546986
122regulation of hippo signaling (GO:0035330)2.86421742
123pentose-phosphate shunt (GO:0006098)2.85891739
124regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85873271
125amyloid precursor protein metabolic process (GO:0042982)2.84790610
126regulation of establishment of cell polarity (GO:2000114)2.83213008
127intraciliary transport (GO:0042073)2.82156058
128macromolecular complex disassembly (GO:0032984)2.79832592
129ribosome assembly (GO:0042255)2.77538271
130positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.77469335
131chaperone-mediated protein transport (GO:0072321)2.76508102
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74667280
133negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.74298534
134behavioral response to nicotine (GO:0035095)2.72854280
135protein neddylation (GO:0045116)2.72763766
136centrosome duplication (GO:0051298)2.72540860
137pseudouridine synthesis (GO:0001522)2.71591790
138negative regulation of cell cycle G2/M phase transition (GO:1902750)2.71511091
139regulation of neurotransmitter uptake (GO:0051580)2.71351874
140termination of RNA polymerase III transcription (GO:0006386)2.71055991
141transcription elongation from RNA polymerase III promoter (GO:0006385)2.71055991
142double-strand break repair via homologous recombination (GO:0000724)2.70682842
143cellular protein complex localization (GO:0034629)2.70157491
144DNA strand elongation involved in DNA replication (GO:0006271)2.69549849
145negative regulation of mast cell activation (GO:0033004)2.69406390
146ribonucleoprotein complex biogenesis (GO:0022613)2.68554783
147protein localization to Golgi apparatus (GO:0034067)2.68101797
148pre-miRNA processing (GO:0031054)2.67880821
149protein complex localization (GO:0031503)2.67795165
150rRNA catabolic process (GO:0016075)2.67182520
151RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66649244
152pteridine-containing compound biosynthetic process (GO:0042559)2.65840743
153maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.65367270
154positive regulation of mRNA processing (GO:0050685)2.64079701
155recombinational repair (GO:0000725)2.63703362
156peripheral nervous system axon ensheathment (GO:0032292)2.62359449
157myelination in peripheral nervous system (GO:0022011)2.62359449
158regulation of cellular amino acid metabolic process (GO:0006521)2.62157535
159histone lysine methylation (GO:0034968)2.61326239
160formation of translation preinitiation complex (GO:0001731)2.60286938
161magnesium ion transport (GO:0015693)2.58148937
162DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.56900353
163regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.56857045
164regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.56857045
165postreplication repair (GO:0006301)2.56827281
166reciprocal DNA recombination (GO:0035825)2.56813699
167reciprocal meiotic recombination (GO:0007131)2.56813699
168spinal cord motor neuron differentiation (GO:0021522)2.53619842
169very long-chain fatty acid metabolic process (GO:0000038)2.53257185
170methionine biosynthetic process (GO:0009086)2.53004872
171respiratory electron transport chain (GO:0022904)2.52556438
172nonmotile primary cilium assembly (GO:0035058)2.51706127
173lipid translocation (GO:0034204)2.51267463
174phospholipid translocation (GO:0045332)2.51267463
175positive regulation of ligase activity (GO:0051351)2.51216043
176peptidyl-histidine modification (GO:0018202)2.51153234
177NADH dehydrogenase complex assembly (GO:0010257)2.50841698
178mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50841698
179mitochondrial respiratory chain complex I assembly (GO:0032981)2.50841698
180mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50830392
1817-methylguanosine mRNA capping (GO:0006370)2.50148601
182regulation of ligase activity (GO:0051340)2.50089566
183nuclear-transcribed mRNA catabolic process (GO:0000956)2.49995173
184protein targeting to mitochondrion (GO:0006626)2.49549977
185IMP metabolic process (GO:0046040)2.49486301
186protein targeting to lysosome (GO:0006622)2.49438519
187establishment of protein localization to vacuole (GO:0072666)2.49438519
188protein targeting to vacuole (GO:0006623)2.49438519
189attachment of spindle microtubules to kinetochore (GO:0008608)2.49319883
190establishment of nucleus localization (GO:0040023)2.49124763
191pyrimidine nucleobase catabolic process (GO:0006208)2.48830480
192positive regulation of histone H3-K4 methylation (GO:0051571)2.48420574
193regulation of centrosome duplication (GO:0010824)2.47009322
194ncRNA catabolic process (GO:0034661)2.46818988
195regulation of developmental pigmentation (GO:0048070)2.46318318
196nerve growth factor signaling pathway (GO:0038180)2.42988322
197replicative senescence (GO:0090399)2.42611053
198regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.41629923
199positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.41629923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.73228503
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.33044208
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.99466272
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.57639398
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51489841
6* GABP_17652178_ChIP-ChIP_JURKAT_Human3.49385491
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.38494735
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26717768
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25715567
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.25262838
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23305506
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.21699035
13SALL1_21062744_ChIP-ChIP_HESCs_Human3.18885865
14EST1_17652178_ChIP-ChIP_JURKAT_Human3.13646710
15MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04239521
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98947916
17GBX2_23144817_ChIP-Seq_PC3_Human2.84265907
18IGF1R_20145208_ChIP-Seq_DFB_Human2.72802182
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.72733298
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72290298
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61460219
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58828071
23ZNF274_21170338_ChIP-Seq_K562_Hela2.55582054
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53595830
25VDR_22108803_ChIP-Seq_LS180_Human2.48552978
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.45452715
27XRN2_22483619_ChIP-Seq_HELA_Human2.40509719
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.36186387
29EWS_26573619_Chip-Seq_HEK293_Human2.29368315
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.27341721
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.27060241
32DCP1A_22483619_ChIP-Seq_HELA_Human2.23731193
33* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23065033
34VDR_23849224_ChIP-Seq_CD4+_Human2.20220193
35TAF15_26573619_Chip-Seq_HEK293_Human2.15791194
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12846726
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12567285
38ZFX_18555785_ChIP-Seq_MESCs_Mouse2.11667057
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08687241
40P300_19829295_ChIP-Seq_ESCs_Human2.05393000
41SRF_21415370_ChIP-Seq_HL-1_Mouse2.03290749
42FUS_26573619_Chip-Seq_HEK293_Human2.02254197
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00144914
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97437814
45GABP_19822575_ChIP-Seq_HepG2_Human1.92655277
46AR_21909140_ChIP-Seq_LNCAP_Human1.92187865
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89365578
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85332683
49* STAT3_23295773_ChIP-Seq_U87_Human1.85318173
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84266329
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.80695811
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80444038
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.80400509
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.79971501
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78192848
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77699096
57SMAD4_21799915_ChIP-Seq_A2780_Human1.77148915
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76086275
59ER_23166858_ChIP-Seq_MCF-7_Human1.70889304
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69754124
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69368236
62* FOXP3_21729870_ChIP-Seq_TREG_Human1.68910302
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67638658
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66166203
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65832192
66BCAT_22108803_ChIP-Seq_LS180_Human1.63597170
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62045305
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61832610
69TTF2_22483619_ChIP-Seq_HELA_Human1.60973709
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.60858886
71TCF4_23295773_ChIP-Seq_U87_Human1.60621255
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60527764
73* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60074644
74ZNF263_19887448_ChIP-Seq_K562_Human1.59721611
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56720836
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56060758
77TP53_16413492_ChIP-PET_HCT116_Human1.54544819
78CBP_20019798_ChIP-Seq_JUKART_Human1.54382069
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54382069
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52881589
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52804489
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51737579
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51550118
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.51010437
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49895659
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49121327
87E2F7_22180533_ChIP-Seq_HELA_Human1.47788027
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46428588
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46219766
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45987109
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.45573381
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45016753
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44131017
94AR_21572438_ChIP-Seq_LNCaP_Human1.43470718
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.43447995
96TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.43410850
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42284903
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41843140
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.41325070
100ELK1_22589737_ChIP-Seq_MCF10A_Human1.40909535
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39526777
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38882881
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38882881
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.38272176
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37945460
106AR_25329375_ChIP-Seq_VCAP_Human1.37878387
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37433981
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35934728
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.35180471
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35030736
111P53_22387025_ChIP-Seq_ESCs_Mouse1.34622618
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34451997
113RUNX2_22187159_ChIP-Seq_PCA_Human1.34346804
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33778177
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32727610
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32245814
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30827071
118HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29998655
119TCF4_22108803_ChIP-Seq_LS180_Human1.29973321
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.29963279
121ELK1_19687146_ChIP-ChIP_HELA_Human1.29553082
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29051968
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.27762113
124IRF1_19129219_ChIP-ChIP_H3396_Human1.27231772
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.26991474
126CMYC_18555785_Chip-Seq_ESCs_Mouse1.25979814
127EZH2_22144423_ChIP-Seq_EOC_Human1.25372259
128SOX17_20123909_ChIP-Seq_XEN_Mouse1.24320135
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23959933
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.22111046
131* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21663659
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21454777
133ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20819514
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19523346
135STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18899305
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18840314
137E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17359192
138YY1_21170310_ChIP-Seq_MESCs_Mouse1.17214518
139OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16589133
140P300_18555785_Chip-Seq_ESCs_Mouse1.16538785
141* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15638105
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15537557
143FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15520991
144STAT3_18555785_Chip-Seq_ESCs_Mouse1.15307810
145CDX2_22108803_ChIP-Seq_LS180_Human1.14287215
146* TFEB_21752829_ChIP-Seq_HELA_Human1.12395843
147TBX5_21415370_ChIP-Seq_HL-1_Mouse1.11740357
148KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11596758
149KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11596758
150KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11596758
151SOX2_18555785_Chip-Seq_ESCs_Mouse1.10865005
152ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10653419
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10423195
154FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10379217
155OCT4_18555785_Chip-Seq_ESCs_Mouse1.10222378
156* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09994920
157KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09501938
158* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09448127
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09392613
160MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08664471
161SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08089952
162SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07779635
163SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07295024
164TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07282509
165GATA1_22025678_ChIP-Seq_K562_Human1.05093597
166* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04685255
167TBL1_22424771_ChIP-Seq_293T_Human1.04411639
168FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04184142
169SMAD4_21741376_ChIP-Seq_EPCs_Human1.04180679
170KDM2B_26808549_Chip-Seq_REH_Human1.04081778
171POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03872340
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03387503
173STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03156455
174NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02815631
175NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02680243
176AHR_22903824_ChIP-Seq_MCF-7_Human1.02646257
177EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02414070
178ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01599216
179EOMES_21245162_ChIP-Seq_HESCs_Human1.01264420
180STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00838631
181KDM5A_27292631_Chip-Seq_BREAST_Human1.00409039
182CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98574191
183FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97733882
184SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97568339
185CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97384518
186SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96912618
187YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95302146
188HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95209449
189TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93524002
190MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92799090
191DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91749073
192EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90812455
193CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90307894
194* FOXP1_21924763_ChIP-Seq_HESCs_Human0.90039860
195RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87202045
196TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84406291
197TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81419221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.29065512
2MP0000569_abnormal_digit_pigmentation5.09672327
3MP0003806_abnormal_nucleotide_metabolis4.56057943
4MP0000920_abnormal_myelination3.96680901
5MP0008877_abnormal_DNA_methylation2.95533037
6MP0003787_abnormal_imprinting2.57591653
7MP0000747_muscle_weakness2.52556121
8MP0002638_abnormal_pupillary_reflex2.48877576
9MP0003950_abnormal_plasma_membrane2.47168831
10MP0000427_abnormal_hair_cycle2.47023334
11MP0004957_abnormal_blastocyst_morpholog2.46840025
12MP0002009_preneoplasia2.46319639
13MP0000749_muscle_degeneration2.32311574
14MP0001529_abnormal_vocalization2.31549451
15MP0005410_abnormal_fertilization2.20452442
16MP0005551_abnormal_eye_electrophysiolog2.20163661
17MP0004134_abnormal_chest_morphology2.13452103
18MP0006036_abnormal_mitochondrial_physio2.13076144
19MP0005670_abnormal_white_adipose2.11033289
20MP0008438_abnormal_cutaneous_collagen2.07845401
21MP0004185_abnormal_adipocyte_glucose2.02508183
22MP0004145_abnormal_muscle_electrophysio1.96919142
23MP0003890_abnormal_embryonic-extraembry1.96473937
24MP0004036_abnormal_muscle_relaxation1.95286298
25MP0000383_abnormal_hair_follicle1.92931666
26MP0000462_abnormal_digestive_system1.90061345
27MP0004084_abnormal_cardiac_muscle1.88455100
28MP0004272_abnormal_basement_membrane1.88062822
29MP0000013_abnormal_adipose_tissue1.85632908
30MP0008932_abnormal_embryonic_tissue1.84415764
31MP0010094_abnormal_chromosome_stability1.84211100
32MP0002938_white_spotting1.82828642
33MP0002095_abnormal_skin_pigmentation1.79544076
34MP0005174_abnormal_tail_pigmentation1.78764181
35MP0004043_abnormal_pH_regulation1.72997883
36MP0001485_abnormal_pinna_reflex1.72828389
37MP0003136_yellow_coat_color1.71778306
38MP0003690_abnormal_glial_cell1.66549307
39MP0001661_extended_life_span1.62458749
40MP0001324_abnormal_eye_pigmentation1.61664108
41MP0005075_abnormal_melanosome_morpholog1.60659407
42MP0005623_abnormal_meninges_morphology1.59069687
43MP0005253_abnormal_eye_physiology1.57915546
44MP0002396_abnormal_hematopoietic_system1.57774127
45MP0003656_abnormal_erythrocyte_physiolo1.57512636
46MP0005058_abnormal_lysosome_morphology1.56183011
47MP0005666_abnormal_adipose_tissue1.55587293
48MP0000371_diluted_coat_color1.53361907
49MP0003186_abnormal_redox_activity1.53229913
50MP0001984_abnormal_olfaction1.53083485
51MP0000015_abnormal_ear_pigmentation1.51956627
52MP0001905_abnormal_dopamine_level1.51450030
53MP0003121_genomic_imprinting1.44293062
54MP0000003_abnormal_adipose_tissue1.42858820
55MP0003221_abnormal_cardiomyocyte_apopto1.41194982
56MP0008058_abnormal_DNA_repair1.40740376
57MP0005375_adipose_tissue_phenotype1.40212340
58MP0002928_abnormal_bile_duct1.40202835
59MP0003329_amyloid_beta_deposits1.39996425
60MP0003567_abnormal_fetal_cardiomyocyte1.38751957
61MP0001730_embryonic_growth_arrest1.37004165
62MP0003693_abnormal_embryo_hatching1.35508532
63MP0005330_cardiomyopathy1.32650360
64MP0009115_abnormal_fat_cell1.32633913
65MP0005275_abnormal_skin_tensile1.30626196
66MP0001348_abnormal_lacrimal_gland1.30165256
67MP0005310_abnormal_salivary_gland1.30067988
68MP0008260_abnormal_autophagy1.29484283
69MP0004130_abnormal_muscle_cell1.27690441
70MP0006276_abnormal_autonomic_nervous1.26066539
71MP0006054_spinal_hemorrhage1.25913339
72MP0002653_abnormal_ependyma_morphology1.24768940
73MP0009384_cardiac_valve_regurgitation1.24556057
74MP0003634_abnormal_glial_cell1.23836471
75MP0002269_muscular_atrophy1.23695807
76MP0000778_abnormal_nervous_system1.23238878
77MP0002876_abnormal_thyroid_physiology1.22796704
78MP0002233_abnormal_nose_morphology1.22425334
79MP0001293_anophthalmia1.21867966
80MP0000751_myopathy1.17635056
81MP0002106_abnormal_muscle_physiology1.17395342
82MP0004885_abnormal_endolymph1.16782558
83MP0003252_abnormal_bile_duct1.13762778
84MP0003123_paternal_imprinting1.13472992
85MP0009840_abnormal_foam_cell1.13196865
86MP0008007_abnormal_cellular_replicative1.12476223
87MP0003943_abnormal_hepatobiliary_system1.12275243
88MP0005501_abnormal_skin_physiology1.10148749
89MP0004142_abnormal_muscle_tone1.10072552
90MP0000762_abnormal_tongue_morphology1.08534465
91MP0000750_abnormal_muscle_regeneration1.06597530
92MP0009250_abnormal_appendicular_skeleto1.05693749
93MP0001299_abnormal_eye_distance/1.05208212
94MP0002837_dystrophic_cardiac_calcinosis1.05182181
95MP0000759_abnormal_skeletal_muscle1.04852090
96MP0003632_abnormal_nervous_system1.04442000
97MP0004215_abnormal_myocardial_fiber1.03826793
98MP0005386_behavior/neurological_phenoty1.03243786
99MP0004924_abnormal_behavior1.03243786
100MP0002166_altered_tumor_susceptibility1.03230241
101MP0000358_abnormal_cell_content/1.02921962
102MP0008995_early_reproductive_senescence1.02012072
103MP0003077_abnormal_cell_cycle1.01757679
104MP0008789_abnormal_olfactory_epithelium0.99187893
105MP0005171_absent_coat_pigmentation0.98941266
106MP0000647_abnormal_sebaceous_gland0.97757541
107MP0005389_reproductive_system_phenotype0.97389193
108MP0001929_abnormal_gametogenesis0.95908972
109MP0000631_abnormal_neuroendocrine_gland0.95475557
110MP0003183_abnormal_peptide_metabolism0.94877878
111MP0005369_muscle_phenotype0.93814971
112MP0009379_abnormal_foot_pigmentation0.92929239
113MP0005645_abnormal_hypothalamus_physiol0.92763150
114MP0001986_abnormal_taste_sensitivity0.92468735
115MP0004087_abnormal_muscle_fiber0.92319286
116MP0005195_abnormal_posterior_eye0.92066765
117MP0001501_abnormal_sleep_pattern0.89756390
118MP0008961_abnormal_basal_metabolism0.89709319
119MP0002080_prenatal_lethality0.89701832
120MP0003195_calcinosis0.89271576
121MP0002796_impaired_skin_barrier0.88891223
122MP0000465_gastrointestinal_hemorrhage0.88828440
123MP0003763_abnormal_thymus_physiology0.88682606
124MP0003718_maternal_effect0.87734355
125MP0004381_abnormal_hair_follicle0.85354301
126MP0010307_abnormal_tumor_latency0.85131623
127MP0010678_abnormal_skin_adnexa0.83600076
128MP0003315_abnormal_perineum_morphology0.82107040
129MP0004147_increased_porphyrin_level0.82091494
130MP0006138_congestive_heart_failure0.80948373
131MP0004133_heterotaxia0.80729675
132MP0003646_muscle_fatigue0.80091099
133MP0002075_abnormal_coat/hair_pigmentati0.79517788
134MP0003937_abnormal_limbs/digits/tail_de0.79308548
135MP0002971_abnormal_brown_adipose0.77877562
136MP0002229_neurodegeneration0.77423681
137MP0003698_abnormal_male_reproductive0.77324032
138MP0009046_muscle_twitch0.76352138
139MP0005391_vision/eye_phenotype0.76166199
140MP0001145_abnormal_male_reproductive0.76095412
141MP0001697_abnormal_embryo_size0.74687583
142MP0002752_abnormal_somatic_nervous0.74268657
143MP0001486_abnormal_startle_reflex0.74234722
144MP0002210_abnormal_sex_determination0.73360200
145MP0002067_abnormal_sensory_capabilities0.72578761
146MP0000372_irregular_coat_pigmentation0.72511100
147MP0006072_abnormal_retinal_apoptosis0.72339411
148MP0002102_abnormal_ear_morphology0.72333321
149MP0002168_other_aberrant_phenotype0.72201542
150MP0002138_abnormal_hepatobiliary_system0.71937727
151MP0002006_tumorigenesis0.71786528
152MP0002092_abnormal_eye_morphology0.71369946
153MP0002234_abnormal_pharynx_morphology0.71076457
154MP0006035_abnormal_mitochondrial_morpho0.71058414
155MP0003172_abnormal_lysosome_physiology0.70288547
156MP0000653_abnormal_sex_gland0.69609186
157MP0000733_abnormal_muscle_development0.69366373
158MP0005266_abnormal_metabolism0.69311585
159MP0004197_abnormal_fetal_growth/weight/0.69184506
160MP0001958_emphysema0.68293804
161MP0008775_abnormal_heart_ventricle0.68222136
162MP0005584_abnormal_enzyme/coenzyme_acti0.68151018
163MP0001919_abnormal_reproductive_system0.66929305
164MP0002751_abnormal_autonomic_nervous0.66777649
165MP0002160_abnormal_reproductive_system0.65594361
166MP0000955_abnormal_spinal_cord0.65227991
167MP0003045_fibrosis0.65007043
168MP0000516_abnormal_urinary_system0.64912609
169MP0005367_renal/urinary_system_phenotyp0.64912609
170MP0001119_abnormal_female_reproductive0.64905325
171MP0002127_abnormal_cardiovascular_syste0.63717483
172MP0005394_taste/olfaction_phenotype0.60751604

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)5.06156340
2Increased serum pyruvate (HP:0003542)5.06156340
3Cerebral hypomyelination (HP:0006808)4.86503114
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.91847666
5Degeneration of the lateral corticospinal tracts (HP:0002314)3.91847666
6Genetic anticipation (HP:0003743)3.80088325
7Volvulus (HP:0002580)3.62952240
8Segmental peripheral demyelination/remyelination (HP:0003481)3.57198796
9Peripheral hypomyelination (HP:0007182)3.57068284
10Insidious onset (HP:0003587)3.47494884
11Termporal pattern (HP:0011008)3.47494884
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.45811281
13Gaze-evoked nystagmus (HP:0000640)3.42587365
14Chronic hepatic failure (HP:0100626)3.38786774
15Pancreatic cysts (HP:0001737)3.35022651
16Acute necrotizing encephalopathy (HP:0006965)3.33239960
17Hepatocellular necrosis (HP:0001404)3.30418698
18Hepatic necrosis (HP:0002605)3.28866853
19CNS hypomyelination (HP:0003429)3.24378979
20Hyperventilation (HP:0002883)3.16955600
21Abnormality of cells of the erythroid lineage (HP:0012130)3.16736255
22Abnormal mitochondria in muscle tissue (HP:0008316)3.08078230
23Medial flaring of the eyebrow (HP:0010747)3.06963313
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.04490121
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.04490121
26Leukodystrophy (HP:0002415)3.02650827
27Retinal dysplasia (HP:0007973)3.00082752
28Pancreatic fibrosis (HP:0100732)2.99729386
29True hermaphroditism (HP:0010459)2.98912476
30Protruding tongue (HP:0010808)2.94662077
31Acute encephalopathy (HP:0006846)2.92801543
32Mitochondrial inheritance (HP:0001427)2.92121605
33Gait imbalance (HP:0002141)2.89113364
34Stridor (HP:0010307)2.86355365
35Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.82937742
36Congenital stationary night blindness (HP:0007642)2.78891740
37Abnormal number of erythroid precursors (HP:0012131)2.78399092
38Abnormality of the renal cortex (HP:0011035)2.78304952
39Nephrogenic diabetes insipidus (HP:0009806)2.77463762
40Thyroiditis (HP:0100646)2.76232649
41Congenital primary aphakia (HP:0007707)2.75194033
42Neurofibrillary tangles (HP:0002185)2.74717117
43Absent speech (HP:0001344)2.73016540
44Postnatal microcephaly (HP:0005484)2.69010193
45Increased CSF lactate (HP:0002490)2.68523667
46Fair hair (HP:0002286)2.67534003
47Congenital ichthyosiform erythroderma (HP:0007431)2.66334718
48Molar tooth sign on MRI (HP:0002419)2.66208675
49Abnormality of midbrain morphology (HP:0002418)2.66208675
50Type II lissencephaly (HP:0007260)2.64308508
51Abnormality of the renal medulla (HP:0100957)2.63505239
52Progressive macrocephaly (HP:0004481)2.60152402
53Spastic paraparesis (HP:0002313)2.59552069
54Acute myeloid leukemia (HP:0004808)2.58083087
55Lipid accumulation in hepatocytes (HP:0006561)2.58070717
56Nephronophthisis (HP:0000090)2.56886188
57Ulnar claw (HP:0001178)2.56871698
58Onion bulb formation (HP:0003383)2.51073008
59Muscle fiber splitting (HP:0003555)2.49436113
60Drooling (HP:0002307)2.44957520
61Poor coordination (HP:0002370)2.44350143
62Increased hepatocellular lipid droplets (HP:0006565)2.44247511
63Febrile seizures (HP:0002373)2.41449092
64Parakeratosis (HP:0001036)2.41220239
653-Methylglutaconic aciduria (HP:0003535)2.39733516
66Attenuation of retinal blood vessels (HP:0007843)2.37584761
67Rhabdomyolysis (HP:0003201)2.36001501
68Progressive cerebellar ataxia (HP:0002073)2.35930467
69Abnormality of the corticospinal tract (HP:0002492)2.35629662
70Intestinal atresia (HP:0011100)2.35135378
71Increased serum lactate (HP:0002151)2.35123883
72Stomach cancer (HP:0012126)2.33621403
73Genital tract atresia (HP:0001827)2.31348847
74Clumsiness (HP:0002312)2.31344890
75Aplasia/Hypoplasia of the tibia (HP:0005772)2.30713324
76Stenosis of the external auditory canal (HP:0000402)2.29285011
77Broad-based gait (HP:0002136)2.29040977
78Multiple enchondromatosis (HP:0005701)2.27161177
79Excessive salivation (HP:0003781)2.26953676
80Tubular atrophy (HP:0000092)2.26353763
81Vaginal atresia (HP:0000148)2.26350101
82Respiratory failure (HP:0002878)2.25974754
83Abnormality of chromosome stability (HP:0003220)2.25378512
84Delayed epiphyseal ossification (HP:0002663)2.23286994
85Widely spaced teeth (HP:0000687)2.23260136
86Abnormal drinking behavior (HP:0030082)2.22397340
87Polydipsia (HP:0001959)2.22397340
88Cerebellar dysplasia (HP:0007033)2.21501136
89Lactic acidosis (HP:0003128)2.20709622
90Macrocytic anemia (HP:0001972)2.20184644
91Truncal obesity (HP:0001956)2.19601006
92Steppage gait (HP:0003376)2.18769322
93Chromsome breakage (HP:0040012)2.13384681
94Panhypogammaglobulinemia (HP:0003139)2.13141164
95Increased muscle lipid content (HP:0009058)2.12846760
96Abnormality of the umbilical cord (HP:0010881)2.12727233
97Progressive inability to walk (HP:0002505)2.12680200
98Abnormal hemoglobin (HP:0011902)2.11398669
99Congenital hepatic fibrosis (HP:0002612)2.11076114
100Hypoplasia of the thymus (HP:0000778)2.10691718
101Tubulointerstitial nephritis (HP:0001970)2.10533682
102Abnormal pupillary function (HP:0007686)2.10387935
103Hyporeflexia of lower limbs (HP:0002600)2.10167007
104Small hand (HP:0200055)2.08587489
105Tented upper lip vermilion (HP:0010804)2.06978072
106Astigmatism (HP:0000483)2.06974687
107Myoglobinuria (HP:0002913)2.06795533
108Premature skin wrinkling (HP:0100678)2.05792653
109Abnormal auditory evoked potentials (HP:0006958)2.05697780
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05553164
111Dicarboxylic aciduria (HP:0003215)2.05553164
112Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05419722
113Short foot (HP:0001773)2.05370719
114Progressive muscle weakness (HP:0003323)2.04216441
115Hypoplastic pelvis (HP:0008839)2.02703087
116Papillary thyroid carcinoma (HP:0002895)2.01899002
117Lissencephaly (HP:0001339)2.01063431
118Foot dorsiflexor weakness (HP:0009027)2.00508031
119Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99380605
120Hypoplasia of the uterus (HP:0000013)1.98962001
121Acute lymphatic leukemia (HP:0006721)1.98227711
122Hypoplastic labia majora (HP:0000059)1.98161708
123Colon cancer (HP:0003003)1.97764156
124Cystic liver disease (HP:0006706)1.97472368
125Increased intramyocellular lipid droplets (HP:0012240)1.97343681
126Calcaneovalgus deformity (HP:0001848)1.97309144
127Hepatosplenomegaly (HP:0001433)1.97048259
128Esophageal atresia (HP:0002032)1.96802302
129Cerebral edema (HP:0002181)1.95960817
130Exercise intolerance (HP:0003546)1.95147212
131Hip dysplasia (HP:0001385)1.94832241
132CNS demyelination (HP:0007305)1.93981622
133Sensory axonal neuropathy (HP:0003390)1.92848139
134Abnormality of the salivary glands (HP:0010286)1.92818143
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.92635480
136Renal Fanconi syndrome (HP:0001994)1.92541378
137Abnormal protein glycosylation (HP:0012346)1.92405791
138Abnormal glycosylation (HP:0012345)1.92405791
139Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92405791
140Abnormal protein N-linked glycosylation (HP:0012347)1.92405791
141Abnormal rod and cone electroretinograms (HP:0008323)1.92315809
142Bony spicule pigmentary retinopathy (HP:0007737)1.91319089
143Hammertoe (HP:0001765)1.90723731
144Abnormality of the foot musculature (HP:0001436)1.89095750
145Birth length less than 3rd percentile (HP:0003561)1.88779336
146Reticulocytopenia (HP:0001896)1.88116387
147Hypoplastic ischia (HP:0003175)1.87750580
148Clubbing of toes (HP:0100760)1.87677707
149Abnormality of the ischium (HP:0003174)1.86180514
150Sloping forehead (HP:0000340)1.85667039
151Abnormality of the labia majora (HP:0012881)1.85081741
152Muscle stiffness (HP:0003552)1.84924811
153Abnormality of T cell number (HP:0011839)1.84451804
154Cupped ear (HP:0000378)1.84335182
155Central scotoma (HP:0000603)1.84213128
156Increased neuronal autofluorescent lipopigment (HP:0002074)1.84097813
157Gowers sign (HP:0003391)1.83715590
158Enlarged kidneys (HP:0000105)1.81940419
159Aplasia/hypoplasia of the uterus (HP:0008684)1.81657322
160Deformed tarsal bones (HP:0008119)1.81628653
161Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81446158
162Generalized hypopigmentation of hair (HP:0011358)1.81232750
163Asplenia (HP:0001746)1.81081276
164Inability to walk (HP:0002540)1.80468355
165Amyotrophic lateral sclerosis (HP:0007354)1.80449332
166Exercise-induced muscle cramps (HP:0003710)1.79652249
167Abnormality of alanine metabolism (HP:0010916)1.79387183
168Hyperalaninemia (HP:0003348)1.79387183
169Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79387183
170Failure to thrive in infancy (HP:0001531)1.78683791
171T lymphocytopenia (HP:0005403)1.78482697
172Loss of speech (HP:0002371)1.78481317
173Distal arthrogryposis (HP:0005684)1.78022332
174Nemaline bodies (HP:0003798)1.76496370
175Postaxial foot polydactyly (HP:0001830)1.75979634
176Partial agenesis of the corpus callosum (HP:0001338)1.75399285
177Abnormality of the heme biosynthetic pathway (HP:0010472)1.75058305
178Emotional lability (HP:0000712)1.74467625
179Neuroendocrine neoplasm (HP:0100634)1.74405790
180Abnormality of glycine metabolism (HP:0010895)1.73629155
181Abnormality of serine family amino acid metabolism (HP:0010894)1.73629155
182Dialeptic seizures (HP:0011146)1.70970001
183Tubulointerstitial abnormality (HP:0001969)1.70590645
184Delayed puberty (HP:0000823)1.69608881
185Polyuria (HP:0000103)1.68559884
186Highly arched eyebrow (HP:0002553)1.67411857
187Abnormality of DNA repair (HP:0003254)1.67297588
188Neoplasm of the adrenal cortex (HP:0100641)1.67058374
189Renal cortical cysts (HP:0000803)1.66640238
190Aplasia/Hypoplasia of the tongue (HP:0010295)1.66622742
191Abnormality of the axillary hair (HP:0100134)1.65513247
192Abnormality of secondary sexual hair (HP:0009888)1.65513247
193Broad foot (HP:0001769)1.65122131
194Retinitis pigmentosa (HP:0000510)1.64485783
195Severe combined immunodeficiency (HP:0004430)1.63488169
196Sandal gap (HP:0001852)1.63367826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.89173627
2STK394.36269476
3EPHB13.57072804
4BUB13.39760590
5TESK23.37262795
6MAPKAPK52.92864016
7NME22.57437134
8TNIK2.51984447
9MKNK22.44343157
10WEE12.28772054
11EIF2AK12.26000587
12STK162.20458173
13BCKDK2.18107444
14LIMK12.14062920
15WNK42.09417133
16AKT32.09156470
17MET2.05740243
18WNK32.01342823
19PRPF4B2.00832701
20TRIM281.97603649
21ACVR1B1.91261544
22OXSR11.90189289
23BRD41.88093060
24FLT31.84446034
25CAMK1D1.72162906
26BRSK21.67757343
27CDK191.65178119
28TAOK31.63987070
29PDK31.60821072
30PDK41.60821072
31TLK11.59285310
32MST41.55453734
33MKNK11.54501165
34CAMK1G1.51528300
35MAP3K41.51447326
36STK38L1.51102391
37BCR1.50726832
38MAPK131.47770939
39TESK11.44351223
40ZAK1.42692722
41PBK1.42523451
42NUAK11.40544103
43PASK1.33312783
44LATS11.32514660
45RPS6KB21.28258342
46PIK3CG1.27347917
47LRRK21.26721652
48TEC1.23788680
49DYRK21.22072813
50CAMKK21.21542747
51TGFBR11.18583810
52ERBB31.17548026
53CASK1.16746637
54UHMK11.15457155
55SGK21.15447814
56EIF2AK31.12141347
57MUSK1.11620853
58MAP3K71.08648856
59INSRR1.05892757
60NLK1.04600336
61ADRBK21.00459844
62PRKAA20.98082530
63SCYL20.97570373
64ARAF0.95957431
65OBSCN0.91989173
66ILK0.91791507
67PKN10.90764241
68KIT0.88500565
69MAP4K20.88422966
70STK30.88257646
71PDK20.87906100
72CSNK1G30.87607492
73GRK10.87227953
74EPHA20.87020698
75TRPM70.86553244
76NTRK10.86086309
77PRKAA10.84179483
78TXK0.83487553
79PAK10.81846898
80VRK10.79996913
81KDR0.79838176
82SGK4940.79491042
83SGK2230.79491042
84MELK0.77512499
85ROCK20.77099313
86RPS6KA50.74729114
87KSR20.74647375
88IKBKE0.74259060
89PLK40.73017826
90BLK0.71842616
91TAOK20.71146122
92DYRK30.71001819
93DYRK1A0.70757194
94TTN0.70078861
95STK110.69509661
96WNK10.69485990
97MAP3K80.68494164
98AURKA0.67604508
99NEK20.66869123
100IRAK20.64804527
101MAP2K20.64537736
102BRAF0.64328586
103MARK30.62939774
104ATM0.62878311
105IRAK10.62686995
106NME10.61502531
107TNK20.61048312
108NTRK30.60785620
109SRPK10.58320127
110CSNK1G10.57540573
111CLK10.57466065
112PAK40.56632791
113CDK140.55734875
114PIM20.54495469
115PKN20.53140098
116CSNK1A1L0.53125743
117ATR0.53061919
118PIM10.52054877
119EPHA40.51340306
120TIE10.51081226
121CDK60.50915501
122MAPK150.50894174
123PNCK0.50565550
124CAMK40.50466334
125TYRO30.49772681
126CAMK2D0.49639932
127MOS0.48686577
128PRKG20.47835461
129PRKD10.47774815
130TTK0.46981766
131PAK30.46424293
132ADRBK10.45493638
133BRSK10.45216733
134SGK10.44354303
135CSNK2A20.44222052
136NEK10.43842679
137SGK30.42719735
138ITK0.42366764
139MARK10.41990213
140JAK10.41913159
141CHUK0.41070225
142PTK20.40888900
143PHKG10.40871292
144PHKG20.40871292
145CDK70.40338935
146CDC70.40154227
147MAP2K30.38554352
148ERBB20.37750190
149FGFR30.37732208
150RPS6KB10.37486181
151MAP3K20.37416775
152CDK30.37277253
153CDK80.36718434
154YES10.36702599
155ABL10.36154739
156PRKCH0.35891253
157CHEK10.35664851
158PRKCE0.35197851
159CHEK20.35159166
160PAK20.34409597
161MAPK110.34399922
162BMPR1B0.34276959
163FGFR20.34271392
164CSNK1G20.34259839
165STK100.34158408
166PIK3CA0.34154861
167MAP3K110.33909995
168BTK0.33518493
169NEK90.33093939
170CSNK1D0.32590911
171CDK11A0.32309605
172PRKACB0.30892466
173PINK10.29557130

Predicted pathways (KEGG)

RankGene SetZ-score
1* Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.68333246
2Fatty acid elongation_Homo sapiens_hsa000623.57278256
3Steroid biosynthesis_Homo sapiens_hsa001003.47139482
4Ribosome_Homo sapiens_hsa030103.46151362
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.26028251
6Proteasome_Homo sapiens_hsa030503.01667360
7DNA replication_Homo sapiens_hsa030302.39103701
8RNA polymerase_Homo sapiens_hsa030202.37751084
9Protein export_Homo sapiens_hsa030602.31610559
10Dorso-ventral axis formation_Homo sapiens_hsa043202.29898059
11Fanconi anemia pathway_Homo sapiens_hsa034602.24930702
12Mismatch repair_Homo sapiens_hsa034302.23593882
13Oxidative phosphorylation_Homo sapiens_hsa001902.07794023
14Parkinsons disease_Homo sapiens_hsa050122.05032636
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.01672544
16Phototransduction_Homo sapiens_hsa047441.91989023
17Propanoate metabolism_Homo sapiens_hsa006401.86339349
18Folate biosynthesis_Homo sapiens_hsa007901.86263975
19Ether lipid metabolism_Homo sapiens_hsa005651.85269702
20Nucleotide excision repair_Homo sapiens_hsa034201.84486828
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76672165
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74546643
23Vitamin B6 metabolism_Homo sapiens_hsa007501.73706177
24ABC transporters_Homo sapiens_hsa020101.69144051
25Lysine degradation_Homo sapiens_hsa003101.68211671
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64554369
27Circadian rhythm_Homo sapiens_hsa047101.62781744
28Pyruvate metabolism_Homo sapiens_hsa006201.59539354
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57709371
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57299997
31Spliceosome_Homo sapiens_hsa030401.55621146
32Fatty acid metabolism_Homo sapiens_hsa012121.52952234
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.42055854
34Basal transcription factors_Homo sapiens_hsa030221.41233448
35Huntingtons disease_Homo sapiens_hsa050161.40502315
36Sulfur metabolism_Homo sapiens_hsa009201.37101143
37RNA transport_Homo sapiens_hsa030131.36146255
38Sulfur relay system_Homo sapiens_hsa041221.35548507
39Pyrimidine metabolism_Homo sapiens_hsa002401.35012448
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30662987
41Tryptophan metabolism_Homo sapiens_hsa003801.27922766
42Butanoate metabolism_Homo sapiens_hsa006501.26271730
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25308465
44Alzheimers disease_Homo sapiens_hsa050101.25047079
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22730621
46Caffeine metabolism_Homo sapiens_hsa002321.21989101
47TGF-beta signaling pathway_Homo sapiens_hsa043501.20758422
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19567182
49Carbon metabolism_Homo sapiens_hsa012001.19544789
50Arginine and proline metabolism_Homo sapiens_hsa003301.16532324
51Linoleic acid metabolism_Homo sapiens_hsa005911.16503004
52Glutathione metabolism_Homo sapiens_hsa004801.16497501
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13706061
54Homologous recombination_Homo sapiens_hsa034401.13211857
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.11879220
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09156859
57FoxO signaling pathway_Homo sapiens_hsa040681.09085747
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07243694
59Fatty acid degradation_Homo sapiens_hsa000711.05281055
60Taste transduction_Homo sapiens_hsa047421.04566640
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01118384
62Pentose phosphate pathway_Homo sapiens_hsa000301.00456281
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96632957
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.96052914
65Selenocompound metabolism_Homo sapiens_hsa004500.95654241
66Base excision repair_Homo sapiens_hsa034100.95105744
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94012803
68Biosynthesis of amino acids_Homo sapiens_hsa012300.92996217
69Inositol phosphate metabolism_Homo sapiens_hsa005620.92831752
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.89867087
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89685642
72Cell cycle_Homo sapiens_hsa041100.89559775
73Nicotine addiction_Homo sapiens_hsa050330.84300219
74Non-homologous end-joining_Homo sapiens_hsa034500.83373333
75Asthma_Homo sapiens_hsa053100.81126672
76Sphingolipid metabolism_Homo sapiens_hsa006000.80583493
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78263564
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78173958
79Purine metabolism_Homo sapiens_hsa002300.77409296
80RNA degradation_Homo sapiens_hsa030180.77001607
81Olfactory transduction_Homo sapiens_hsa047400.76312424
82Metabolic pathways_Homo sapiens_hsa011000.75870485
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74585964
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73158147
85Retinol metabolism_Homo sapiens_hsa008300.72570739
86Tight junction_Homo sapiens_hsa045300.72221685
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71687988
88Long-term depression_Homo sapiens_hsa047300.71366980
89Chemical carcinogenesis_Homo sapiens_hsa052040.69723780
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67244297
91Colorectal cancer_Homo sapiens_hsa052100.66718118
92Primary immunodeficiency_Homo sapiens_hsa053400.66202108
93Measles_Homo sapiens_hsa051620.64875195
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64823347
95Cardiac muscle contraction_Homo sapiens_hsa042600.63677636
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63160349
97Nitrogen metabolism_Homo sapiens_hsa009100.62891821
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61702403
99Arachidonic acid metabolism_Homo sapiens_hsa005900.61643402
100Peroxisome_Homo sapiens_hsa041460.61392975
101Melanoma_Homo sapiens_hsa052180.60332922
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.60042075
103ErbB signaling pathway_Homo sapiens_hsa040120.59065931
104One carbon pool by folate_Homo sapiens_hsa006700.58985999
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58835531
106T cell receptor signaling pathway_Homo sapiens_hsa046600.58795733
107Morphine addiction_Homo sapiens_hsa050320.58558624
108Ras signaling pathway_Homo sapiens_hsa040140.58516400
109Choline metabolism in cancer_Homo sapiens_hsa052310.57829839
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56341927
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56305432
112Ovarian steroidogenesis_Homo sapiens_hsa049130.55527998
113Renin secretion_Homo sapiens_hsa049240.52855302
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52566979
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51634460
116Hedgehog signaling pathway_Homo sapiens_hsa043400.50948471
117Platelet activation_Homo sapiens_hsa046110.50576154
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.50571215
119Glutamatergic synapse_Homo sapiens_hsa047240.50135832
120MicroRNAs in cancer_Homo sapiens_hsa052060.49490922
121Oxytocin signaling pathway_Homo sapiens_hsa049210.48972596
122Dopaminergic synapse_Homo sapiens_hsa047280.46569835
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45861401
124Graft-versus-host disease_Homo sapiens_hsa053320.45509983
125MAPK signaling pathway_Homo sapiens_hsa040100.45496844
126mTOR signaling pathway_Homo sapiens_hsa041500.45080163
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42835984
128Thyroid cancer_Homo sapiens_hsa052160.42723700
129Chronic myeloid leukemia_Homo sapiens_hsa052200.41003200
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40547582
131Prolactin signaling pathway_Homo sapiens_hsa049170.40336061
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40043180
133Prostate cancer_Homo sapiens_hsa052150.39746733
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39253217
135N-Glycan biosynthesis_Homo sapiens_hsa005100.38837071
136Serotonergic synapse_Homo sapiens_hsa047260.38798295
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38722904
138Histidine metabolism_Homo sapiens_hsa003400.38158390
139Hippo signaling pathway_Homo sapiens_hsa043900.38029934
140ECM-receptor interaction_Homo sapiens_hsa045120.36259955
141Renal cell carcinoma_Homo sapiens_hsa052110.35871423
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35774488
143Systemic lupus erythematosus_Homo sapiens_hsa053220.34886307
144Regulation of autophagy_Homo sapiens_hsa041400.33444387
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.32811217
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.30703841
147Oocyte meiosis_Homo sapiens_hsa041140.30366953
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27327920
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27290813
150Fatty acid biosynthesis_Homo sapiens_hsa000610.27253039
151beta-Alanine metabolism_Homo sapiens_hsa004100.26215265
152Lysosome_Homo sapiens_hsa041420.26036494
153AMPK signaling pathway_Homo sapiens_hsa041520.21911748
154Alcoholism_Homo sapiens_hsa050340.21279417
155mRNA surveillance pathway_Homo sapiens_hsa030150.21009755
156Fat digestion and absorption_Homo sapiens_hsa049750.19273538
157Epstein-Barr virus infection_Homo sapiens_hsa051690.19014060
158Endocytosis_Homo sapiens_hsa041440.18868537
159PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18816005
160Shigellosis_Homo sapiens_hsa051310.17247973
161Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16541676
162p53 signaling pathway_Homo sapiens_hsa041150.16244750
163Glycerolipid metabolism_Homo sapiens_hsa005610.15844947
164Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14922538
165Leukocyte transendothelial migration_Homo sapiens_hsa046700.14450497

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