FNTAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.22709813
2translational termination (GO:0006415)6.85042709
3ribosomal small subunit assembly (GO:0000028)6.67832723
4ribosomal small subunit biogenesis (GO:0042274)5.97510668
5translational elongation (GO:0006414)5.92643565
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.91614151
7paraxial mesoderm development (GO:0048339)5.82741579
8protein targeting to ER (GO:0045047)5.78443170
9cotranslational protein targeting to membrane (GO:0006613)5.76254594
10neuron remodeling (GO:0016322)5.72260137
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.63863916
12viral life cycle (GO:0019058)5.63251933
13protein complex biogenesis (GO:0070271)5.38708111
14protein localization to endoplasmic reticulum (GO:0070972)5.28224643
15cellular protein complex disassembly (GO:0043624)5.17313606
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.07701941
17regulation of mitochondrial translation (GO:0070129)5.07329536
18mitochondrial respiratory chain complex assembly (GO:0033108)4.94798483
19translational initiation (GO:0006413)4.90008825
20somatic diversification of immune receptors via somatic mutation (GO:0002566)4.65666393
21somatic hypermutation of immunoglobulin genes (GO:0016446)4.65666393
22protein-cofactor linkage (GO:0018065)4.62907853
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.62419924
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.52138040
25positive regulation of prostaglandin secretion (GO:0032308)4.43491364
26protein complex disassembly (GO:0043241)4.42454745
27chromatin remodeling at centromere (GO:0031055)4.32665129
28CENP-A containing nucleosome assembly (GO:0034080)4.26065935
29iron-sulfur cluster assembly (GO:0016226)4.23905053
30metallo-sulfur cluster assembly (GO:0031163)4.23905053
31macromolecular complex disassembly (GO:0032984)4.18769382
32spliceosomal complex assembly (GO:0000245)4.15380708
33mitotic G2 DNA damage checkpoint (GO:0007095)4.15203704
34cell proliferation in forebrain (GO:0021846)4.07989389
35regulation of gene silencing by RNA (GO:0060966)4.06019438
36regulation of posttranscriptional gene silencing (GO:0060147)4.06019438
37regulation of gene silencing by miRNA (GO:0060964)4.06019438
38protein complex localization (GO:0031503)4.03165054
39maturation of SSU-rRNA (GO:0030490)4.02663619
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.99672309
41NADH dehydrogenase complex assembly (GO:0010257)3.99672309
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99672309
43positive regulation of respiratory burst (GO:0060267)3.91424382
44mismatch repair (GO:0006298)3.81087134
45regulation of prostaglandin secretion (GO:0032306)3.77788519
46otic vesicle formation (GO:0030916)3.77346309
47protein targeting to membrane (GO:0006612)3.77235917
48respiratory electron transport chain (GO:0022904)3.71043964
49histone exchange (GO:0043486)3.66425724
50negative regulation of osteoblast proliferation (GO:0033689)3.65570985
51histone mRNA metabolic process (GO:0008334)3.65283706
52nuclear-transcribed mRNA catabolic process (GO:0000956)3.64590258
53regulation of mesoderm development (GO:2000380)3.64234025
54substrate-dependent cell migration (GO:0006929)3.59770125
55electron transport chain (GO:0022900)3.59285685
56regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.52192245
57mitotic G2/M transition checkpoint (GO:0044818)3.45981450
58mRNA catabolic process (GO:0006402)3.45570221
59omega-hydroxylase P450 pathway (GO:0097267)3.43122316
60ATP synthesis coupled proton transport (GO:0015986)3.38136039
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38136039
62translation (GO:0006412)3.35724324
63telomere maintenance via semi-conservative replication (GO:0032201)3.35607495
64regulation of cell fate specification (GO:0042659)3.30685680
65positive regulation of SMAD protein import into nucleus (GO:0060391)3.29686230
66ribosomal large subunit biogenesis (GO:0042273)3.26150487
67resolution of meiotic recombination intermediates (GO:0000712)3.22765171
68RNA catabolic process (GO:0006401)3.20424922
69folic acid transport (GO:0015884)3.20365410
70histone H4-K12 acetylation (GO:0043983)3.12591310
71viral protein processing (GO:0019082)3.10742283
72anterior/posterior axis specification, embryo (GO:0008595)3.07461892
73regulation of mitotic spindle checkpoint (GO:1903504)3.04178787
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04178787
75protein K11-linked deubiquitination (GO:0035871)2.99671948
76DNA replication-independent nucleosome organization (GO:0034724)2.95053836
77DNA replication-independent nucleosome assembly (GO:0006336)2.95053836
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88432336
79negative regulation of translation, ncRNA-mediated (GO:0040033)2.88432336
80regulation of translation, ncRNA-mediated (GO:0045974)2.88432336
81mitotic recombination (GO:0006312)2.88302926
82cellular response to hepatocyte growth factor stimulus (GO:0035729)2.88113424
83response to hepatocyte growth factor (GO:0035728)2.88113424
84telomere maintenance via recombination (GO:0000722)2.88070877
85spliceosomal snRNP assembly (GO:0000387)2.87070029
86regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.86969315
87negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.84568378
88inner ear receptor cell development (GO:0060119)2.79881846
89prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.78340056
90regulation of gene silencing (GO:0060968)2.76031933
91cellular protein complex localization (GO:0034629)2.75277940
92glutamine metabolic process (GO:0006541)2.72099265
93UDP-N-acetylglucosamine metabolic process (GO:0006047)2.71909102
94positive regulation of T cell cytokine production (GO:0002726)2.71763065
95nucleotide-excision repair, DNA gap filling (GO:0006297)2.70423916
96phosphatidylserine acyl-chain remodeling (GO:0036150)2.69176433
97endothelial cell morphogenesis (GO:0001886)2.69096703
98lysine metabolic process (GO:0006553)2.69041298
99lysine catabolic process (GO:0006554)2.69041298
100atrial cardiac muscle cell action potential (GO:0086014)2.64866356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.86397778
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.95027757
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.80637650
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.79483851
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.53201003
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.22175873
7FUS_26573619_Chip-Seq_HEK293_Human3.09195691
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.01594237
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44268349
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.29309936
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26696543
12BCAT_22108803_ChIP-Seq_LS180_Human2.23501497
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20209458
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.15372263
15P300_19829295_ChIP-Seq_ESCs_Human2.12082784
16MYC_18940864_ChIP-ChIP_HL60_Human2.11331160
17ELK1_19687146_ChIP-ChIP_HELA_Human2.04748817
18EWS_26573619_Chip-Seq_HEK293_Human2.03248225
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95896846
20TP53_16413492_ChIP-PET_HCT116_Human1.85779737
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.84828679
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83332935
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80789550
24POU5F1_16153702_ChIP-ChIP_HESCs_Human1.79892608
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79534205
26SOX2_19829295_ChIP-Seq_ESCs_Human1.79048974
27NANOG_19829295_ChIP-Seq_ESCs_Human1.79048974
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71720803
29VDR_22108803_ChIP-Seq_LS180_Human1.67573639
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63361873
31TP53_22573176_ChIP-Seq_HFKS_Human1.59930931
32E2F7_22180533_ChIP-Seq_HELA_Human1.59116838
33NANOG_16153702_ChIP-ChIP_HESCs_Human1.58465497
34TAF15_26573619_Chip-Seq_HEK293_Human1.58252016
35AR_21572438_ChIP-Seq_LNCaP_Human1.57485999
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.57382006
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55751123
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.53020829
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51966942
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51058995
41GBX2_23144817_ChIP-Seq_PC3_Human1.50538266
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.50151192
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45281665
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42099526
45AR_25329375_ChIP-Seq_VCAP_Human1.39479921
46ZNF274_21170338_ChIP-Seq_K562_Hela1.37323822
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37028734
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35417064
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35161202
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.32458300
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30599383
52VDR_23849224_ChIP-Seq_CD4+_Human1.28467682
53STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27063107
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20538717
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20179750
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20179750
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.16551365
58RNF2_27304074_Chip-Seq_NSC_Mouse1.04326284
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03011466
60TCF4_23295773_ChIP-Seq_U87_Human1.02154158
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01434280
62AR_20517297_ChIP-Seq_VCAP_Human1.00258334
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97871938
64ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97810452
65SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97295991
66FLI1_27457419_Chip-Seq_LIVER_Mouse0.95321722
67SMAD3_21741376_ChIP-Seq_HESCs_Human0.94653247
68TTF2_22483619_ChIP-Seq_HELA_Human0.94412442
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92625718
70GABP_17652178_ChIP-ChIP_JURKAT_Human0.92136489
71IRF1_19129219_ChIP-ChIP_H3396_Human0.92111420
72RUNX2_22187159_ChIP-Seq_PCA_Human0.92100161
73SMAD4_21799915_ChIP-Seq_A2780_Human0.92062728
74CDX2_22108803_ChIP-Seq_LS180_Human0.90865194
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90612481
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87859443
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87620366
78CBP_20019798_ChIP-Seq_JUKART_Human0.87620366
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.87241531
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87241531
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86482302
82TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85834181
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85415509
84TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84493722
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84454178
86FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82952402
87ER_23166858_ChIP-Seq_MCF-7_Human0.82806840
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.82786573
89TCF4_22108803_ChIP-Seq_LS180_Human0.82593594
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82564842
91NFYB_21822215_ChIP-Seq_K562_Human0.81838495
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.81603576
93HTT_18923047_ChIP-ChIP_STHdh_Human0.80568188
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80128849
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.79260885
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79260885
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.79260885
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78989076
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78676888
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.78670938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode8.74204884
2MP0009379_abnormal_foot_pigmentation6.37287961
3MP0002396_abnormal_hematopoietic_system4.01590188
4MP0003941_abnormal_skin_development3.81827939
5MP0002736_abnormal_nociception_after3.75426419
6MP0005248_abnormal_Harderian_gland3.37548882
7MP0008004_abnormal_stomach_pH3.31202702
8MP0003890_abnormal_embryonic-extraembry2.97890013
9MP0003136_yellow_coat_color2.84506444
10MP0001293_anophthalmia2.82611272
11MP0003567_abnormal_fetal_cardiomyocyte2.80233090
12MP0004742_abnormal_vestibular_system2.79425729
13MP0003195_calcinosis2.75523200
14MP0005084_abnormal_gallbladder_morpholo2.26950414
15MP0001968_abnormal_touch/_nociception2.14468584
16MP0008057_abnormal_DNA_replication2.10017456
17MP0003787_abnormal_imprinting1.98656015
18MP0004885_abnormal_endolymph1.80776241
19MP0000566_synostosis1.68510888
20MP0005377_hearing/vestibular/ear_phenot1.66186131
21MP0003878_abnormal_ear_physiology1.66186131
22MP0010030_abnormal_orbit_morphology1.66105486
23MP0006072_abnormal_retinal_apoptosis1.59394806
24MP0002837_dystrophic_cardiac_calcinosis1.47620099
25MP0003942_abnormal_urinary_system1.36783156
26MP0001764_abnormal_homeostasis1.34451705
27MP0001188_hyperpigmentation1.33248966
28MP0000383_abnormal_hair_follicle1.32614749
29MP0001286_abnormal_eye_development1.23726577
30MP0001486_abnormal_startle_reflex1.19428237
31MP0000579_abnormal_nail_morphology1.15692925
32MP0003868_abnormal_feces_composition1.13858978
33MP0009672_abnormal_birth_weight1.13210249
34MP0002697_abnormal_eye_size1.11889517
35MP0003121_genomic_imprinting1.11287660
36MP0002277_abnormal_respiratory_mucosa1.09712237
37MP0004808_abnormal_hematopoietic_stem1.09415215
38MP0005075_abnormal_melanosome_morpholog1.07939073
39MP0010678_abnormal_skin_adnexa1.05974127
40MP0008995_early_reproductive_senescence1.03797244
41MP0003119_abnormal_digestive_system1.03620399
42MP0000537_abnormal_urethra_morphology1.03483455
43MP0002928_abnormal_bile_duct1.01773866
44MP0000428_abnormal_craniofacial_morphol0.98322825
45MP0002234_abnormal_pharynx_morphology0.95907603
46MP0006035_abnormal_mitochondrial_morpho0.91553434
47MP0001485_abnormal_pinna_reflex0.91215039
48MP0005253_abnormal_eye_physiology0.90301531
49MP0009780_abnormal_chondrocyte_physiolo0.90130198
50MP0003122_maternal_imprinting0.85744135
51MP0004924_abnormal_behavior0.84756908
52MP0005386_behavior/neurological_phenoty0.84756908
53MP0003186_abnormal_redox_activity0.80659679
54MP0000427_abnormal_hair_cycle0.79973397
55MP0008872_abnormal_physiological_respon0.79835915
56MP0001663_abnormal_digestive_system0.79065014
57MP0009764_decreased_sensitivity_to0.76840964
58MP0002009_preneoplasia0.76711929
59MP0002102_abnormal_ear_morphology0.73816115
60MP0001346_abnormal_lacrimal_gland0.73078558
61MP0001440_abnormal_grooming_behavior0.73003902
62MP0002138_abnormal_hepatobiliary_system0.72607425
63MP0005220_abnormal_exocrine_pancreas0.71978217
64MP0001502_abnormal_circadian_rhythm0.71757674
65MP0003252_abnormal_bile_duct0.70400752
66MP0000631_abnormal_neuroendocrine_gland0.70147176
67MP0000490_abnormal_crypts_of0.69619184
68MP0010771_integument_phenotype0.69499348
69MP0005391_vision/eye_phenotype0.69361788
70MP0005551_abnormal_eye_electrophysiolog0.68416916
71MP0004142_abnormal_muscle_tone0.67373437
72MP0005083_abnormal_biliary_tract0.66850133
73MP0002095_abnormal_skin_pigmentation0.65661028
74MP0005381_digestive/alimentary_phenotyp0.65622299
75MP0008873_increased_physiological_sensi0.65194883
76MP0008877_abnormal_DNA_methylation0.63605327
77MP0002092_abnormal_eye_morphology0.62970725
78MP0009384_cardiac_valve_regurgitation0.62722095
79MP0000026_abnormal_inner_ear0.62508038
80MP0010386_abnormal_urinary_bladder0.62219964
81MP0003115_abnormal_respiratory_system0.61647074
82MP0000778_abnormal_nervous_system0.60869482
83MP0001501_abnormal_sleep_pattern0.60579739
84MP0004145_abnormal_muscle_electrophysio0.60191909
85MP0004133_heterotaxia0.59069119
86MP0003943_abnormal_hepatobiliary_system0.58911635
87MP0003937_abnormal_limbs/digits/tail_de0.58037157
88MP0000613_abnormal_salivary_gland0.55066339
89MP0008058_abnormal_DNA_repair0.54512378
90MP0000647_abnormal_sebaceous_gland0.52982127
91MP0005423_abnormal_somatic_nervous0.52853562
92MP0005195_abnormal_posterior_eye0.48031396
93MP0001963_abnormal_hearing_physiology0.47328688
94MP0001324_abnormal_eye_pigmentation0.46947838
95MP0005187_abnormal_penis_morphology0.46823226
96MP0005666_abnormal_adipose_tissue0.46593851
97MP0002111_abnormal_tail_morphology0.45211392
98MP0010094_abnormal_chromosome_stability0.44062049
99MP0003111_abnormal_nucleus_morphology0.43078295
100MP0005319_abnormal_enzyme/_coenzyme0.42438866

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.51641228
2Colon cancer (HP:0003003)5.48963396
3Reticulocytopenia (HP:0001896)4.94045705
4Maternal diabetes (HP:0009800)4.42521576
5Increased hepatocellular lipid droplets (HP:0006565)4.29324839
6Abnormality of the labia minora (HP:0012880)3.80212584
7Lipid accumulation in hepatocytes (HP:0006561)3.69910516
8Broad metatarsal (HP:0001783)3.67621871
9Absent septum pellucidum (HP:0001331)3.63346044
10Basal cell carcinoma (HP:0002671)3.58641076
11Absent hand (HP:0004050)3.51722805
12Abnormal number of erythroid precursors (HP:0012131)3.44021308
13Abnormality of cells of the erythroid lineage (HP:0012130)3.43141261
14Abnormality of the septum pellucidum (HP:0007375)3.22174520
15Biliary tract neoplasm (HP:0100574)3.22065687
16Exertional dyspnea (HP:0002875)3.19695997
17Abnormality of the middle phalanges of the toes (HP:0010183)3.15833701
18Abnormality of the lacrimal duct (HP:0011481)3.06057685
19Porencephaly (HP:0002132)2.97851033
20Renal Fanconi syndrome (HP:0001994)2.92523573
21Abdominal situs inversus (HP:0003363)2.91174594
22Abnormality of abdominal situs (HP:0011620)2.91174594
23Hyperphosphaturia (HP:0003109)2.85986577
24Megalencephaly (HP:0001355)2.85168349
25Supernumerary ribs (HP:0005815)2.83904322
26Increased intramyocellular lipid droplets (HP:0012240)2.83567821
27Medulloblastoma (HP:0002885)2.83470032
28Hypoglycemic seizures (HP:0002173)2.81012313
29Birth length less than 3rd percentile (HP:0003561)2.77025552
30Hypoplastic labia majora (HP:0000059)2.76506112
31Partial duplication of thumb phalanx (HP:0009944)2.74515227
32Hepatoblastoma (HP:0002884)2.72306110
33Axonal loss (HP:0003447)2.68100744
34Stomach cancer (HP:0012126)2.67230950
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67053528
36Hyperinsulinemic hypoglycemia (HP:0000825)2.66136265
37Coronal craniosynostosis (HP:0004440)2.63450244
38Nasolacrimal duct obstruction (HP:0000579)2.61364365
39Hypoglycemic coma (HP:0001325)2.60204199
40Abnormality of the labia majora (HP:0012881)2.55728784
41Supernumerary bones of the axial skeleton (HP:0009144)2.50073462
42Abnormality of the nasolacrimal system (HP:0000614)2.48281784
43Humeroradial synostosis (HP:0003041)2.43208748
44Synostosis involving the elbow (HP:0003938)2.43208748
45Macrocytic anemia (HP:0001972)2.39725940
46Duplication of thumb phalanx (HP:0009942)2.39551739
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38173831
48Abnormality of renal resorption (HP:0011038)2.37882452
49Abnormality of DNA repair (HP:0003254)2.36590670
50Oral leukoplakia (HP:0002745)2.31174513
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28031249
52Abnormality of the renal cortex (HP:0011035)2.26200569
53Partial duplication of the phalanx of hand (HP:0009999)2.25267745
54Aplastic anemia (HP:0001915)2.24400234
55Optic nerve hypoplasia (HP:0000609)2.24367046
56Breast hypoplasia (HP:0003187)2.23898006
57Neoplasm of the small intestine (HP:0100833)2.23378175
58Pancreatic cysts (HP:0001737)2.22867521
59Glioma (HP:0009733)2.21906076
60Chronic otitis media (HP:0000389)2.21610261
61Increased muscle lipid content (HP:0009058)2.21132617
62Absent eyebrow (HP:0002223)2.17419290
63Abnormality of incisor morphology (HP:0011063)2.15825590
64Type II lissencephaly (HP:0007260)2.13887931
65Thickened helices (HP:0000391)2.10965633
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.09030979
67Abnormal urine phosphate concentration (HP:0012599)2.08987115
68Hemivertebrae (HP:0002937)2.07679652
69Pallor (HP:0000980)2.07055899
70Choanal stenosis (HP:0000452)2.05614805
71Aqueductal stenosis (HP:0002410)2.04990581
72Ependymoma (HP:0002888)2.03120483
73Wide nose (HP:0000445)1.99382280
74Cerebellar dysplasia (HP:0007033)1.99266960
75Labial hypoplasia (HP:0000066)1.99004048
76Neoplasm of the adrenal cortex (HP:0100641)1.96439077
77Neoplasm of the rectum (HP:0100743)1.95581946
78Agnosia (HP:0010524)1.95105517
79High anterior hairline (HP:0009890)1.94579469
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94540998
81Entropion (HP:0000621)1.91215316
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89462962
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89462962
84Rhabdomyosarcoma (HP:0002859)1.89439929
85Bronchomalacia (HP:0002780)1.88849014
86Enlarged penis (HP:0000040)1.88503294
87Hypothermia (HP:0002045)1.88404998
88Conical tooth (HP:0000698)1.86818992
89Pigmentary retinal degeneration (HP:0001146)1.86162050
90Symptomatic seizures (HP:0011145)1.81209981
91Volvulus (HP:0002580)1.79230949
92Confusion (HP:0001289)1.78794707
93Neoplasm of the colon (HP:0100273)1.78568977
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77153476
95Prolonged neonatal jaundice (HP:0006579)1.75966062
96Short middle phalanx of finger (HP:0005819)1.75840005
97Skull defect (HP:0001362)1.73480089
98Short hallux (HP:0010109)1.72798690
99Increased IgM level (HP:0003496)1.72774673
100Hypoplastic female external genitalia (HP:0012815)1.72750749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.96954529
2CDK194.82452302
3ZAK4.11538871
4STK163.80071984
5WNK33.33114830
6NUAK13.30110596
7EIF2AK32.88814106
8LATS12.49033138
9EPHA42.41225126
10RIPK42.36595765
11FGFR22.30526826
12STK382.17513935
13BCKDK1.94557118
14MAP3K101.85331080
15BMPR21.83773259
16BRD41.71220761
17OXSR11.47516999
18TEC1.45844107
19FGFR11.43832630
20NME21.43137152
21CDK121.39399946
22BRSK21.39023996
23STK38L1.30969062
24NLK1.29687880
25CDC71.21699099
26EIF2AK21.17244835
27ADRBK21.13888133
28ACVR1B1.12633294
29BMPR1B1.09175149
30MAP3K91.06952250
31PKN21.02851635
32ITK1.01498301
33PASK1.01067323
34MAP3K21.00435044
35TTK0.96082673
36TNIK0.93628843
37BMX0.92569713
38GRK10.92136045
39FRK0.89893193
40NEK20.86350550
41MARK30.84176348
42SRPK10.83175711
43MAP4K20.76645820
44INSRR0.76097267
45PLK30.72483439
46MKNK10.72178429
47FGFR30.71321336
48FLT30.66156526
49CASK0.65257466
50MAP4K10.64041925
51PRKG10.63897208
52STK40.63756045
53IKBKB0.63730766
54DMPK0.62633608
55MATK0.62295849
56PIK3CA0.61750223
57FGR0.54515393
58YES10.54100464
59PIM10.52878769
60PTK60.52290550
61CDK60.49908516
62NTRK30.46651245
63DYRK20.46620157
64RPS6KB20.45050883
65STK30.44837702
66CDK70.44385342
67PNCK0.43661597
68NEK60.42946338
69SYK0.42511839
70MKNK20.42494082
71PRKACB0.42218866
72TIE10.40979594
73ATM0.40973708
74MUSK0.39686557
75CSNK2A20.37817198
76EGFR0.37523809
77ADRBK10.37243336
78CDK20.36815769
79PDK10.36665958
80CHEK20.36499038
81IRAK10.36019860
82ABL10.33874762
83PRKCB0.33329474
84RET0.32704039
85KIT0.31994028
86SGK10.31545768
87CSNK1A10.31480801
88BTK0.31323525
89LYN0.31316434
90CSNK1E0.30795607
91TXK0.30784223
92BRSK10.29532790
93CSNK1G20.28603971
94PRKCQ0.27560955
95PRKCG0.26915459
96TGFBR10.26281247
97MAP2K60.25024172
98ILK0.24651828
99CAMK2A0.24481623
100OBSCN0.23836977

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.56963539
2Folate biosynthesis_Homo sapiens_hsa007904.37626075
3Mismatch repair_Homo sapiens_hsa034303.96156163
4Oxidative phosphorylation_Homo sapiens_hsa001903.67579633
5Parkinsons disease_Homo sapiens_hsa050123.43302803
6Sulfur relay system_Homo sapiens_hsa041223.28927683
7Homologous recombination_Homo sapiens_hsa034403.03784225
8DNA replication_Homo sapiens_hsa030302.43437398
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.39404559
10Huntingtons disease_Homo sapiens_hsa050162.31802950
11Nitrogen metabolism_Homo sapiens_hsa009102.17471252
12Alzheimers disease_Homo sapiens_hsa050102.13541182
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99094518
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85331906
15Cardiac muscle contraction_Homo sapiens_hsa042601.72346710
16Nucleotide excision repair_Homo sapiens_hsa034201.71301708
17Fanconi anemia pathway_Homo sapiens_hsa034601.70081057
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64277345
19Proteasome_Homo sapiens_hsa030501.56126148
20Dorso-ventral axis formation_Homo sapiens_hsa043201.54078026
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39794032
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37755930
23Fatty acid degradation_Homo sapiens_hsa000711.34244248
24Phototransduction_Homo sapiens_hsa047441.30455227
25Non-homologous end-joining_Homo sapiens_hsa034501.29445388
26Vitamin digestion and absorption_Homo sapiens_hsa049771.20275608
27Linoleic acid metabolism_Homo sapiens_hsa005911.20266530
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15624645
29Pyruvate metabolism_Homo sapiens_hsa006201.13419387
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13056533
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08150076
32One carbon pool by folate_Homo sapiens_hsa006700.98681409
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98417043
34Systemic lupus erythematosus_Homo sapiens_hsa053220.96089486
35p53 signaling pathway_Homo sapiens_hsa041150.95248661
36Lysine degradation_Homo sapiens_hsa003100.91906811
37Wnt signaling pathway_Homo sapiens_hsa043100.88247511
38Sulfur metabolism_Homo sapiens_hsa009200.87691188
39RNA transport_Homo sapiens_hsa030130.84156331
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79728307
41Selenocompound metabolism_Homo sapiens_hsa004500.76629253
42Primary immunodeficiency_Homo sapiens_hsa053400.74853492
43RNA degradation_Homo sapiens_hsa030180.70263619
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70218789
45TGF-beta signaling pathway_Homo sapiens_hsa043500.69587467
46Thyroid cancer_Homo sapiens_hsa052160.69531645
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69226699
48Spliceosome_Homo sapiens_hsa030400.67564569
49RNA polymerase_Homo sapiens_hsa030200.65682440
50Insulin secretion_Homo sapiens_hsa049110.61581255
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.59518160
52Base excision repair_Homo sapiens_hsa034100.59278597
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.58723889
54Basal transcription factors_Homo sapiens_hsa030220.57740472
55Taste transduction_Homo sapiens_hsa047420.55745826
56HIF-1 signaling pathway_Homo sapiens_hsa040660.53779721
57Protein export_Homo sapiens_hsa030600.52861319
58Tryptophan metabolism_Homo sapiens_hsa003800.51923112
59Ether lipid metabolism_Homo sapiens_hsa005650.48644305
60Butanoate metabolism_Homo sapiens_hsa006500.45845717
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.45769020
62Purine metabolism_Homo sapiens_hsa002300.42709181
63Gastric acid secretion_Homo sapiens_hsa049710.42231290
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40780915
65B cell receptor signaling pathway_Homo sapiens_hsa046620.37380356
66Prostate cancer_Homo sapiens_hsa052150.37337165
67Type I diabetes mellitus_Homo sapiens_hsa049400.37269695
68Long-term potentiation_Homo sapiens_hsa047200.36071761
69Metabolic pathways_Homo sapiens_hsa011000.34651081
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34479210
71mRNA surveillance pathway_Homo sapiens_hsa030150.33356753
72Olfactory transduction_Homo sapiens_hsa047400.33301168
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32707844
74Asthma_Homo sapiens_hsa053100.32135796
75Arachidonic acid metabolism_Homo sapiens_hsa005900.30591417
76Fatty acid metabolism_Homo sapiens_hsa012120.30269214
77Inositol phosphate metabolism_Homo sapiens_hsa005620.29964996
78Pyrimidine metabolism_Homo sapiens_hsa002400.29934046
79Propanoate metabolism_Homo sapiens_hsa006400.29686817
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28466324
81Fat digestion and absorption_Homo sapiens_hsa049750.28234898
82Pancreatic secretion_Homo sapiens_hsa049720.27637105
83Herpes simplex infection_Homo sapiens_hsa051680.27237944
84Hippo signaling pathway_Homo sapiens_hsa043900.26328645
85Hedgehog signaling pathway_Homo sapiens_hsa043400.26296845
86Oocyte meiosis_Homo sapiens_hsa041140.25620695
87Basal cell carcinoma_Homo sapiens_hsa052170.23465872
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22427798
89Arginine biosynthesis_Homo sapiens_hsa002200.22008202
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20664373
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.19818154
92Adherens junction_Homo sapiens_hsa045200.19487619
93Epstein-Barr virus infection_Homo sapiens_hsa051690.18428494
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.17098548
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15407358
96Pentose phosphate pathway_Homo sapiens_hsa000300.15120751
97Axon guidance_Homo sapiens_hsa043600.14763458
98Cell cycle_Homo sapiens_hsa041100.14628993
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14610611
100Long-term depression_Homo sapiens_hsa047300.13440229

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