FNTB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)4.97660522
2positive regulation of mitotic sister chromatid separation (GO:1901970)4.87734421
3positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.87734421
4positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.87734421
5long-chain fatty acid biosynthetic process (GO:0042759)4.62201671
6regulation of gene silencing by RNA (GO:0060966)4.38147809
7regulation of posttranscriptional gene silencing (GO:0060147)4.38147809
8regulation of gene silencing by miRNA (GO:0060964)4.38147809
9DNA deamination (GO:0045006)4.38121029
10regulation of female gonad development (GO:2000194)4.26374756
11formation of translation preinitiation complex (GO:0001731)4.09080562
12regulation of sister chromatid cohesion (GO:0007063)3.94399454
13regulation of nuclear cell cycle DNA replication (GO:0033262)3.89525309
14DNA strand elongation involved in DNA replication (GO:0006271)3.86941370
15cullin deneddylation (GO:0010388)3.78979476
16somatic hypermutation of immunoglobulin genes (GO:0016446)3.75916221
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.75916221
18histone H4-K12 acetylation (GO:0043983)3.75371232
19regulation of meiosis I (GO:0060631)3.74841365
20fatty acid elongation (GO:0030497)3.72617474
21DNA replication initiation (GO:0006270)3.70397526
22DNA strand elongation (GO:0022616)3.65755369
23histone arginine methylation (GO:0034969)3.64138907
24mitotic sister chromatid segregation (GO:0000070)3.62872478
25pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.57014293
26telomere maintenance via semi-conservative replication (GO:0032201)3.54863524
27DNA replication checkpoint (GO:0000076)3.51795010
28protein deneddylation (GO:0000338)3.51179348
29DNA unwinding involved in DNA replication (GO:0006268)3.49432533
30protein localization to kinetochore (GO:0034501)3.46517984
31IMP biosynthetic process (GO:0006188)3.46381331
32nucleobase biosynthetic process (GO:0046112)3.44297299
33metaphase plate congression (GO:0051310)3.43335648
34regulation of spindle organization (GO:0090224)3.42747443
35peptidyl-arginine omega-N-methylation (GO:0035247)3.38287247
36vesicle fusion (GO:0006906)3.34915906
37microtubule depolymerization (GO:0007019)3.32350814
38mitotic chromosome condensation (GO:0007076)3.29318874
39ribosome biogenesis (GO:0042254)3.28596116
40DNA replication-dependent nucleosome organization (GO:0034723)3.28462598
41DNA replication-dependent nucleosome assembly (GO:0006335)3.28462598
42CENP-A containing nucleosome assembly (GO:0034080)3.24425752
43regulation of mitotic spindle organization (GO:0060236)3.23347072
44regulation of integrin-mediated signaling pathway (GO:2001044)3.22096050
45thrombin receptor signaling pathway (GO:0070493)3.20358646
46regulation of acrosome reaction (GO:0060046)3.19661099
47establishment of chromosome localization (GO:0051303)3.18654075
48GDP-mannose metabolic process (GO:0019673)3.17540505
49IMP metabolic process (GO:0046040)3.13653100
50regulation of telomere maintenance via telomerase (GO:0032210)3.10996934
51chromatin remodeling at centromere (GO:0031055)3.08543711
52purine nucleobase biosynthetic process (GO:0009113)3.07499733
53transcription from mitochondrial promoter (GO:0006390)3.06246540
54negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.03657731
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.03422004
56single strand break repair (GO:0000012)3.03254699
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00554207
58viral mRNA export from host cell nucleus (GO:0046784)2.98610613
59regulation of translational fidelity (GO:0006450)2.97631131
60negative regulation of chromosome segregation (GO:0051985)2.97551661
61nucleotide-excision repair, DNA gap filling (GO:0006297)2.96633571
62negative regulation of Ras GTPase activity (GO:0034261)2.96293681
63sister chromatid segregation (GO:0000819)2.95965867
64beta-amyloid metabolic process (GO:0050435)2.94737691
65short-term memory (GO:0007614)2.92835583
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92667691
67pseudouridine synthesis (GO:0001522)2.92430312
68relaxation of smooth muscle (GO:0044557)2.91215436
69folic acid-containing compound biosynthetic process (GO:0009396)2.89530737
70mitotic metaphase plate congression (GO:0007080)2.88979780
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.88462697
72linoleic acid metabolic process (GO:0043651)2.87642198
73spliceosomal snRNP assembly (GO:0000387)2.86918394
74pyrimidine nucleotide catabolic process (GO:0006244)2.86848225
75negative regulation of heart rate (GO:0010459)2.84389641
76protein localization to chromosome, centromeric region (GO:0071459)2.83492176
77mitotic nuclear envelope disassembly (GO:0007077)2.83177588
78negative regulation of homotypic cell-cell adhesion (GO:0034111)2.82886359
79telomere maintenance via recombination (GO:0000722)2.82748141
80negative regulation of reproductive process (GO:2000242)2.82158062
81fusion of sperm to egg plasma membrane (GO:0007342)2.82130260
82negative regulation of norepinephrine secretion (GO:0010700)2.81743922
83protein complex localization (GO:0031503)2.79889132
84transcription-coupled nucleotide-excision repair (GO:0006283)2.79637936
85telomere maintenance via telomere lengthening (GO:0010833)2.79255004
86rRNA modification (GO:0000154)2.77568146
87negative regulation of telomere maintenance (GO:0032205)2.77223859
88negative regulation of mitotic sister chromatid separation (GO:2000816)2.76696459
89negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76696459
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76696459
91negative regulation of sister chromatid segregation (GO:0033046)2.76696459
92mitotic spindle assembly checkpoint (GO:0007094)2.75843500
93deoxyribose phosphate biosynthetic process (GO:0046385)2.75787597
942-deoxyribonucleotide biosynthetic process (GO:0009265)2.75787597
95replication fork processing (GO:0031297)2.74954330
96spindle assembly checkpoint (GO:0071173)2.74359939
97peptidyl-arginine N-methylation (GO:0035246)2.74077531
98peptidyl-arginine methylation (GO:0018216)2.74077531
99negative regulation of protein localization to cell surface (GO:2000009)2.74007724
100acrosome assembly (GO:0001675)2.73936869
101maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72577036
102proteasome assembly (GO:0043248)2.70590578
103positive regulation of endothelial cell differentiation (GO:0045603)2.69336591
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.68164369
105DNA duplex unwinding (GO:0032508)2.68046719
106proline biosynthetic process (GO:0006561)2.67777428
107nuclear envelope reassembly (GO:0031468)2.67152362
108mitotic nuclear envelope reassembly (GO:0007084)2.67152362
109establishment of integrated proviral latency (GO:0075713)2.67004808
110DNA geometric change (GO:0032392)2.66345124
111negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66105783
112microtubule polymerization or depolymerization (GO:0031109)2.65794260
113axon ensheathment in central nervous system (GO:0032291)2.65025417
114central nervous system myelination (GO:0022010)2.65025417
115mitotic recombination (GO:0006312)2.64500977
116establishment of mitochondrion localization (GO:0051654)2.64068502
117base-excision repair (GO:0006284)2.63795505
118positive regulation of chromosome segregation (GO:0051984)2.63324704
119negative regulation of telomerase activity (GO:0051974)2.62992730
120mitochondrial DNA metabolic process (GO:0032042)2.62629137
121coenzyme A biosynthetic process (GO:0015937)2.62358532
122regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62340483
123regulation of exit from mitosis (GO:0007096)2.61868397
124base-excision repair, AP site formation (GO:0006285)2.61730535
125regulation of helicase activity (GO:0051095)2.60891328
126nuclear envelope disassembly (GO:0051081)2.60613146
127membrane disassembly (GO:0030397)2.60613146
128seminiferous tubule development (GO:0072520)2.60397165
129kinetochore organization (GO:0051383)2.59711830
130nodal signaling pathway (GO:0038092)2.59442369
131oocyte development (GO:0048599)2.58000903
132histone H4-K5 acetylation (GO:0043981)2.57450008
133histone H4-K8 acetylation (GO:0043982)2.57450008
134rRNA processing (GO:0006364)2.56514953
135deoxyribonucleotide biosynthetic process (GO:0009263)2.55787393
136pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.55501655
137negative regulation of microtubule depolymerization (GO:0007026)2.55083754
138regulation of DNA methylation (GO:0044030)2.55042960
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.54321509
140regulation of chromosome segregation (GO:0051983)2.54049775
141peptidyl-arginine modification (GO:0018195)2.53748462
142negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.52726000
143mitotic spindle checkpoint (GO:0071174)2.52268965
144regulation of translation in response to stress (GO:0043555)2.51685963
145binding of sperm to zona pellucida (GO:0007339)2.51556522
146regulation of double-strand break repair via homologous recombination (GO:0010569)2.51114110
147cellular protein complex localization (GO:0034629)2.50742572
148ribonucleoprotein complex biogenesis (GO:0022613)2.50594939
149determination of adult lifespan (GO:0008340)2.48877074
150piRNA metabolic process (GO:0034587)2.48604141
151positive regulation of male gonad development (GO:2000020)2.48572541
152regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48050632
153DNA replication-independent nucleosome organization (GO:0034724)2.47903565
154DNA replication-independent nucleosome assembly (GO:0006336)2.47903565
155* prenylation (GO:0097354)2.47776599
156* protein prenylation (GO:0018342)2.47776599
157blood coagulation, intrinsic pathway (GO:0007597)2.47241519
158mismatch repair (GO:0006298)2.46732181
159maturation of 5.8S rRNA (GO:0000460)2.46693708
160spliceosomal complex assembly (GO:0000245)2.46306855
161double-strand break repair via nonhomologous end joining (GO:0006303)2.45552621
162non-recombinational repair (GO:0000726)2.45552621
163polyamine biosynthetic process (GO:0006596)2.44378605
164female gamete generation (GO:0007292)2.44265993
165multicellular organism reproduction (GO:0032504)2.44197035
166adenosine receptor signaling pathway (GO:0001973)2.44016505
167lipoxygenase pathway (GO:0019372)2.42300446
168vesicle targeting (GO:0006903)2.42161515
169metallo-sulfur cluster assembly (GO:0031163)2.42067220
170iron-sulfur cluster assembly (GO:0016226)2.42067220
171histone exchange (GO:0043486)2.38477321
172citrulline biosynthetic process (GO:0019240)2.37832484
173kinetochore assembly (GO:0051382)2.35756865
174regulation of microtubule depolymerization (GO:0031114)2.35649708
175establishment of mitotic spindle localization (GO:0040001)2.34030622
176regulation of catecholamine metabolic process (GO:0042069)2.33954586
177regulation of dopamine metabolic process (GO:0042053)2.33954586
178synaptonemal complex organization (GO:0070193)2.32461403
179negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.31299449
180positive regulation of reproductive process (GO:2000243)2.30150911
181negative regulation of circadian rhythm (GO:0042754)2.27011200
182positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.25147484
183negative regulation of response to food (GO:0032096)2.25021114
184negative regulation of appetite (GO:0032099)2.25021114
185histone H2A acetylation (GO:0043968)2.25020809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.58670238
2EZH2_22144423_ChIP-Seq_EOC_Human6.23214847
3E2F7_22180533_ChIP-Seq_HELA_Human5.98180420
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.64854924
5* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.60014465
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22858379
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.21214915
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.21214915
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.21214915
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.90401112
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87900046
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64922251
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59129236
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.55149871
15GBX2_23144817_ChIP-Seq_PC3_Human2.55042338
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52326959
17* ETS1_20019798_ChIP-Seq_JURKAT_Human2.48370067
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42355124
19* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41391322
20* EST1_17652178_ChIP-ChIP_JURKAT_Human2.40109003
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38839505
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35007564
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34365738
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27678388
25* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.27452488
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.25817006
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16384546
28* HTT_18923047_ChIP-ChIP_STHdh_Human2.13548034
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13524039
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11760786
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.09855131
32VDR_22108803_ChIP-Seq_LS180_Human2.06886902
33XRN2_22483619_ChIP-Seq_HELA_Human2.05445496
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03785940
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03353213
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.99919492
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99514832
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.96315609
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.90972627
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89400837
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87401138
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87346585
43SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.87126062
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85284505
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81638905
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79228998
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.78368148
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77802026
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74321948
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.74022652
51* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73415053
52GABP_19822575_ChIP-Seq_HepG2_Human1.71735206
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.71603491
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.67239450
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64263591
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63270646
57IRF1_19129219_ChIP-ChIP_H3396_Human1.62863416
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62539251
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61536972
60* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60382674
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59752540
62DCP1A_22483619_ChIP-Seq_HELA_Human1.57684959
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56276612
64* VDR_23849224_ChIP-Seq_CD4+_Human1.53941242
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52821385
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51973553
67NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.51318286
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49862345
69* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47367141
70CIITA_25753668_ChIP-Seq_RAJI_Human1.46457750
71TTF2_22483619_ChIP-Seq_HELA_Human1.45015337
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44712943
73TAF15_26573619_Chip-Seq_HEK293_Human1.44489562
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42222796
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42069496
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41901819
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41861660
78MYC_22102868_ChIP-Seq_BL_Human1.41632773
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.41290245
80NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40346115
81FOXP3_21729870_ChIP-Seq_TREG_Human1.39965419
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39771158
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37018428
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34082321
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.33800533
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31269658
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31203149
88POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31123369
89* KDM5A_27292631_Chip-Seq_BREAST_Human1.28186018
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27347762
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27171125
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25871782
93* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24386585
94SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22534640
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22281799
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.21953731
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20172626
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19086941
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18037959
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17940827
101POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17648078
102OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16887558
103TFEB_21752829_ChIP-Seq_HELA_Human1.16281181
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14596108
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.13006774
106NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10947994
107ZNF263_19887448_ChIP-Seq_K562_Human1.10610608
108CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.10412883
109NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09932709
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09751411
111E2F1_21310950_ChIP-Seq_MCF-7_Human1.08660828
112* SRF_21415370_ChIP-Seq_HL-1_Mouse1.07323812
113TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06702129
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06651635
115AR_21909140_ChIP-Seq_LNCAP_Human1.04120195
116ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01357234
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01319313
118WT1_19549856_ChIP-ChIP_CCG9911_Human1.00924675
119* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98400391
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98326160
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97609070
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97334357
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95932666
124KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95870345
125* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.93586391
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.92299815
127KAP1_27257070_Chip-Seq_ESCs_Mouse0.92144083
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89268751
129VDR_21846776_ChIP-Seq_THP-1_Human0.89102324
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.88067270
131* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87837391
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.86248067
133* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85334638
134FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83649275
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83440946
136* SOX17_20123909_ChIP-Seq_XEN_Mouse0.76146532
137CBP_21632823_ChIP-Seq_H3396_Human0.75925007
138* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.74498438
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74427561
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73008508
141TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72605142
142TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71738078
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.71682592
144NANOG_20526341_ChIP-Seq_ESCs_Human0.71274122
145TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68697399
146* REST_18959480_ChIP-ChIP_MESCs_Mouse0.67235447
147E2F1_17053090_ChIP-ChIP_MCF-7_Human0.67213368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.34786247
2MP0008057_abnormal_DNA_replication3.67458216
3MP0005464_abnormal_platelet_physiology3.53268891
4MP0002653_abnormal_ependyma_morphology3.45601593
5MP0004957_abnormal_blastocyst_morpholog3.45134685
6MP0003111_abnormal_nucleus_morphology3.17514910
7MP0010030_abnormal_orbit_morphology3.10304415
8MP0003693_abnormal_embryo_hatching2.95368309
9MP0010094_abnormal_chromosome_stability2.82642831
10* MP0003077_abnormal_cell_cycle2.72780279
11MP0008058_abnormal_DNA_repair2.39491365
12MP0008004_abnormal_stomach_pH2.37831997
13* MP0008932_abnormal_embryonic_tissue2.24018484
14MP0004133_heterotaxia2.19904578
15MP0003136_yellow_coat_color2.18185998
16MP0003123_paternal_imprinting2.16045485
17MP0003880_abnormal_central_pattern2.15832923
18MP0005171_absent_coat_pigmentation2.07903212
19MP0003890_abnormal_embryonic-extraembry2.06410257
20MP0006292_abnormal_olfactory_placode2.05124803
21MP0002736_abnormal_nociception_after2.02820300
22MP0005410_abnormal_fertilization1.88750724
23* MP0000350_abnormal_cell_proliferation1.71379031
24MP0004233_abnormal_muscle_weight1.69432444
25MP0003121_genomic_imprinting1.64748600
26* MP0002085_abnormal_embryonic_tissue1.60840092
27MP0001730_embryonic_growth_arrest1.60404523
28MP0003786_premature_aging1.58093254
29MP0001697_abnormal_embryo_size1.53898930
30MP0008877_abnormal_DNA_methylation1.52269056
31MP0003283_abnormal_digestive_organ1.52048213
32* MP0002084_abnormal_developmental_patter1.49906667
33MP0005423_abnormal_somatic_nervous1.47834556
34MP0006276_abnormal_autonomic_nervous1.46566885
35MP0004859_abnormal_synaptic_plasticity1.46015098
36MP0005646_abnormal_pituitary_gland1.44210280
37MP0001293_anophthalmia1.44017187
38MP0005395_other_phenotype1.42798563
39MP0001672_abnormal_embryogenesis/_devel1.42664570
40MP0005380_embryogenesis_phenotype1.42664570
41MP0008775_abnormal_heart_ventricle1.42327800
42MP0006036_abnormal_mitochondrial_physio1.41932684
43MP0000467_abnormal_esophagus_morphology1.40190327
44MP0004264_abnormal_extraembryonic_tissu1.39701376
45MP0005499_abnormal_olfactory_system1.39042069
46MP0005394_taste/olfaction_phenotype1.39042069
47MP0001968_abnormal_touch/_nociception1.34497864
48MP0008007_abnormal_cellular_replicative1.34164734
49MP0006072_abnormal_retinal_apoptosis1.32982157
50MP0003119_abnormal_digestive_system1.31840513
51* MP0002080_prenatal_lethality1.28623793
52MP0002249_abnormal_larynx_morphology1.28553761
53MP0004084_abnormal_cardiac_muscle1.24933968
54MP0002751_abnormal_autonomic_nervous1.24889049
55MP0003122_maternal_imprinting1.24323289
56MP0002735_abnormal_chemical_nociception1.22864783
57MP0001529_abnormal_vocalization1.22725649
58MP0010368_abnormal_lymphatic_system1.22378032
59MP0004142_abnormal_muscle_tone1.21078129
60MP0000653_abnormal_sex_gland1.20337708
61MP0003806_abnormal_nucleotide_metabolis1.18436884
62MP0008789_abnormal_olfactory_epithelium1.16675992
63MP0003186_abnormal_redox_activity1.15809610
64MP0000049_abnormal_middle_ear1.15539549
65MP0003984_embryonic_growth_retardation1.15276685
66MP0009046_muscle_twitch1.14828865
67MP0000749_muscle_degeneration1.13238619
68MP0000751_myopathy1.13045867
69MP0010352_gastrointestinal_tract_polyps1.12618435
70MP0002086_abnormal_extraembryonic_tissu1.12507322
71MP0004885_abnormal_endolymph1.11805359
72MP0002938_white_spotting1.11111412
73MP0003303_peritoneal_inflammation1.11040284
74MP0000372_irregular_coat_pigmentation1.10698701
75MP0002088_abnormal_embryonic_growth/wei1.10251688
76MP0001986_abnormal_taste_sensitivity1.05538406
77MP0001485_abnormal_pinna_reflex1.04993995
78MP0002161_abnormal_fertility/fecundity1.02772351
79MP0001849_ear_inflammation1.02638376
80MP0000678_abnormal_parathyroid_gland1.02099427
81MP0004036_abnormal_muscle_relaxation1.01892119
82MP0004197_abnormal_fetal_growth/weight/1.01156760
83MP0003755_abnormal_palate_morphology0.99634250
84MP0003699_abnormal_female_reproductive0.99520529
85* MP0000313_abnormal_cell_death0.99393234
86MP0003861_abnormal_nervous_system0.98504130
87MP0003656_abnormal_erythrocyte_physiolo0.97196735
88MP0000762_abnormal_tongue_morphology0.96909658
89MP0005075_abnormal_melanosome_morpholog0.96770261
90MP0005389_reproductive_system_phenotype0.95767242
91MP0002114_abnormal_axial_skeleton0.95229228
92MP0002111_abnormal_tail_morphology0.93742927
93MP0003115_abnormal_respiratory_system0.92528427
94MP0000955_abnormal_spinal_cord0.92259434
95MP0004134_abnormal_chest_morphology0.91925111
96MP0003718_maternal_effect0.90944749
97MP0001119_abnormal_female_reproductive0.89602285
98MP0005551_abnormal_eye_electrophysiolog0.89448184
99MP0004215_abnormal_myocardial_fiber0.89406295
100MP0003698_abnormal_male_reproductive0.86979056
101MP0006138_congestive_heart_failure0.86868108
102MP0002075_abnormal_coat/hair_pigmentati0.86780665
103MP0001905_abnormal_dopamine_level0.84244240
104MP0002932_abnormal_joint_morphology0.84000457
105MP0002295_abnormal_pulmonary_circulatio0.82801056
106MP0000490_abnormal_crypts_of0.82727539
107MP0002210_abnormal_sex_determination0.82059582
108MP0002822_catalepsy0.81936802
109MP0001145_abnormal_male_reproductive0.81755514
110MP0004270_analgesia0.81137413
111MP0001919_abnormal_reproductive_system0.80790593
112MP0002396_abnormal_hematopoietic_system0.80745024
113MP0003566_abnormal_cell_adhesion0.80276788
114MP0000465_gastrointestinal_hemorrhage0.80026934
115MP0005253_abnormal_eye_physiology0.79048266
116MP0000015_abnormal_ear_pigmentation0.78789236
117MP0005508_abnormal_skeleton_morphology0.78642308
118MP0001984_abnormal_olfaction0.77036517
119MP0002116_abnormal_craniofacial_bone0.76755690
120MP0003787_abnormal_imprinting0.76063497
121MP0003879_abnormal_hair_cell0.75979626
122MP0002067_abnormal_sensory_capabilities0.75820706
123* MP0000358_abnormal_cell_content/0.75575633
124MP0001915_intracranial_hemorrhage0.74842228
125MP0000534_abnormal_ureter_morphology0.74784789
126MP0003635_abnormal_synaptic_transmissio0.74582115
127MP0001664_abnormal_digestion0.74405327
128MP0002752_abnormal_somatic_nervous0.71969783
129MP0006035_abnormal_mitochondrial_morpho0.71657657
130MP0005391_vision/eye_phenotype0.70752548
131* MP0002019_abnormal_tumor_incidence0.70719995
132MP0001970_abnormal_pain_threshold0.69398844
133MP0005058_abnormal_lysosome_morphology0.69296946
134MP0000778_abnormal_nervous_system0.69159990
135MP0002733_abnormal_thermal_nociception0.69002043
136MP0001486_abnormal_startle_reflex0.68826075
137MP0001286_abnormal_eye_development0.68733930
138MP0008872_abnormal_physiological_respon0.68206228
139* MP0005384_cellular_phenotype0.68136134
140MP0008260_abnormal_autophagy0.68016444
141MP0003941_abnormal_skin_development0.68006092
142MP0003935_abnormal_craniofacial_develop0.67736950
143MP0003950_abnormal_plasma_membrane0.67496573
144MP0002089_abnormal_postnatal_growth/wei0.67467518
145MP0002269_muscular_atrophy0.67302032
146MP0000343_altered_response_to0.66945593
147MP0003937_abnormal_limbs/digits/tail_de0.66604504
148MP0001963_abnormal_hearing_physiology0.66575540
149MP0003942_abnormal_urinary_system0.65557846
150MP0001929_abnormal_gametogenesis0.65091905
151MP0000230_abnormal_systemic_arterial0.64181249
152MP0010386_abnormal_urinary_bladder0.64161104
153MP0003632_abnormal_nervous_system0.64040763
154MP0002160_abnormal_reproductive_system0.63559697
155MP0000432_abnormal_head_morphology0.63489719
156MP0005621_abnormal_cell_physiology0.63120044
157MP0002152_abnormal_brain_morphology0.62897955
158MP0002233_abnormal_nose_morphology0.62565477
159MP0001186_pigmentation_phenotype0.61887742
160MP0002272_abnormal_nervous_system0.60896218
161MP0002882_abnormal_neuron_morphology0.60671195

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)5.17729919
2Increased mean platelet volume (HP:0011877)5.07365263
3Prolonged bleeding time (HP:0003010)5.01087993
4Menorrhagia (HP:0000132)5.01014189
5Purpura (HP:0000979)4.64420469
6Petechiae (HP:0000967)4.58170174
7Abnormal platelet volume (HP:0011876)4.52617607
8Ependymoma (HP:0002888)4.16832860
9Hypoplastic pelvis (HP:0008839)3.93991200
10Cholecystitis (HP:0001082)3.88557750
11Abnormal gallbladder physiology (HP:0012438)3.88557750
12Tubulointerstitial nephritis (HP:0001970)3.48910180
13Abnormality of the labia minora (HP:0012880)3.45369517
14Birth length less than 3rd percentile (HP:0003561)3.28768087
15Rib fusion (HP:0000902)3.26637280
16Astrocytoma (HP:0009592)3.19498071
17Abnormality of the astrocytes (HP:0100707)3.19498071
18Breast hypoplasia (HP:0003187)3.05373551
19Male infertility (HP:0003251)3.04150319
20Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01203235
21Decreased lacrimation (HP:0000633)2.93337373
22CNS hypomyelination (HP:0003429)2.82159642
23Dyschromatopsia (HP:0007641)2.81718242
24Broad alveolar ridges (HP:0000187)2.75520149
25Long foot (HP:0001833)2.74432734
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.72604627
27Absent radius (HP:0003974)2.69666427
28Carpal bone hypoplasia (HP:0001498)2.65984570
29Gonadal dysgenesis (HP:0000133)2.65206864
30Medulloblastoma (HP:0002885)2.64459577
31Neoplasm of the oral cavity (HP:0100649)2.63681667
32Gingival bleeding (HP:0000225)2.60190846
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.59955853
34Hypoplasia of the fovea (HP:0007750)2.59955853
35Epistaxis (HP:0000421)2.59595697
36Tongue fasciculations (HP:0001308)2.55492241
37Aplasia involving forearm bones (HP:0009822)2.54161990
38Absent forearm bone (HP:0003953)2.54161990
39Abnormality of cochlea (HP:0000375)2.48862089
40Selective tooth agenesis (HP:0001592)2.48490692
41Abnormal ventriculo-arterial connection (HP:0011563)2.47851344
42Transposition of the great arteries (HP:0001669)2.47851344
43Abnormal connection of the cardiac segments (HP:0011545)2.47851344
44Glioma (HP:0009733)2.46340356
45Supernumerary spleens (HP:0009799)2.42070565
46Patellar aplasia (HP:0006443)2.41637625
47Abnormality of the ileum (HP:0001549)2.40537021
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39990473
49Rectovaginal fistula (HP:0000143)2.39936355
50Rectal fistula (HP:0100590)2.39936355
51Hypokinesia (HP:0002375)2.38454143
52Abnormality of the salivary glands (HP:0010286)2.36861133
53Aplasia/hypoplasia of the humerus (HP:0006507)2.36512931
54Esophageal atresia (HP:0002032)2.34412197
55Hyperglycinemia (HP:0002154)2.33135649
56Hypoplastic left heart (HP:0004383)2.32620918
57Morphological abnormality of the inner ear (HP:0011390)2.30707770
58Degeneration of anterior horn cells (HP:0002398)2.30151061
59Abnormality of the anterior horn cell (HP:0006802)2.30151061
60Microvesicular hepatic steatosis (HP:0001414)2.29841792
61Spinal muscular atrophy (HP:0007269)2.29100480
62Muscle fibrillation (HP:0010546)2.28826929
63Autoamputation (HP:0001218)2.28271172
64Hyperlipoproteinemia (HP:0010980)2.28107855
65Upper limb muscle weakness (HP:0003484)2.26949676
66Abnormality of the fovea (HP:0000493)2.22221281
67Aplasia/Hypoplasia of the patella (HP:0006498)2.21455197
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20724672
69Meckel diverticulum (HP:0002245)2.20469914
70Papillary thyroid carcinoma (HP:0002895)2.19285311
71Osteomalacia (HP:0002749)2.19117654
72Atrophy/Degeneration involving motor neurons (HP:0007373)2.18774895
73Shoulder girdle muscle weakness (HP:0003547)2.18543561
74Facial hemangioma (HP:0000329)2.18362148
75Abnormal pupillary function (HP:0007686)2.16770794
76Rhabdomyosarcoma (HP:0002859)2.16371581
77Myokymia (HP:0002411)2.14361128
78Polyphagia (HP:0002591)2.13785764
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.13512879
80Generalized aminoaciduria (HP:0002909)2.13073306
81Short humerus (HP:0005792)2.11529776
82Testicular neoplasm (HP:0010788)2.09142023
83Intestinal fistula (HP:0100819)2.08396113
84Bilateral microphthalmos (HP:0007633)2.06164290
85Abnormality of fatty-acid metabolism (HP:0004359)2.04696601
86Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03933322
87Abnormal lung lobation (HP:0002101)2.03115947
88Basal cell carcinoma (HP:0002671)2.00940510
89Neoplasm of striated muscle (HP:0009728)2.00890002
90Septo-optic dysplasia (HP:0100842)1.99179388
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97847195
92Abnormality of the lower motor neuron (HP:0002366)1.96514764
93Duodenal stenosis (HP:0100867)1.96372953
94Small intestinal stenosis (HP:0012848)1.96372953
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95885210
96Degeneration of the lateral corticospinal tracts (HP:0002314)1.95885210
97Premature graying of hair (HP:0002216)1.95286087
98Hypoplastic heart (HP:0001961)1.94282214
99Increased serum pyruvate (HP:0003542)1.94257153
100Abnormality of glycolysis (HP:0004366)1.94257153
101Broad distal phalanx of finger (HP:0009836)1.94077727
102Limb dystonia (HP:0002451)1.94044728
103Absent thumb (HP:0009777)1.92527580
104Impaired vibration sensation in the lower limbs (HP:0002166)1.91881921
105Infertility (HP:0000789)1.91648325
106Type I transferrin isoform profile (HP:0003642)1.91531656
107Shawl scrotum (HP:0000049)1.90326507
108Vaginal fistula (HP:0004320)1.89982990
109Abnormality of the heme biosynthetic pathway (HP:0010472)1.89945123
110Abdominal situs inversus (HP:0003363)1.89826027
111Abnormality of abdominal situs (HP:0011620)1.89826027
112Concave nail (HP:0001598)1.89555783
113Postnatal microcephaly (HP:0005484)1.89416036
114Chromsome breakage (HP:0040012)1.89089350
115Gastrointestinal atresia (HP:0002589)1.88767484
116Renal Fanconi syndrome (HP:0001994)1.88402798
117Absent epiphyses (HP:0010577)1.88157658
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88157658
119Impaired platelet aggregation (HP:0003540)1.87739436
120Abnormal platelet function (HP:0011869)1.87739436
121Agnosia (HP:0010524)1.87165307
122Premature ovarian failure (HP:0008209)1.86890955
123Alacrima (HP:0000522)1.86828701
124Diaphragmatic weakness (HP:0009113)1.86651028
125Nausea (HP:0002018)1.86155470
126Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85394962
127Abnormality of the preputium (HP:0100587)1.84736390
128Paralysis (HP:0003470)1.84218546
129Large for gestational age (HP:0001520)1.84204366
130Orthostatic hypotension (HP:0001278)1.84159206
131Hypophosphatemic rickets (HP:0004912)1.83076333
132Rough bone trabeculation (HP:0100670)1.83040997
133Trismus (HP:0000211)1.81135937
134Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.79152051
135Heterochromia iridis (HP:0001100)1.78602390
136Duplicated collecting system (HP:0000081)1.77958096
137Peripheral hypomyelination (HP:0007182)1.77929698
138Progressive muscle weakness (HP:0003323)1.77604915
139Abnormality of lateral ventricle (HP:0030047)1.76933269
140Abnormality of the renal collecting system (HP:0004742)1.76795098
141Dry hair (HP:0011359)1.73924421
142White forelock (HP:0002211)1.71777714
143Amyotrophic lateral sclerosis (HP:0007354)1.71250922
144Bifid tongue (HP:0010297)1.70269268
145Urinary urgency (HP:0000012)1.69301956
146Conjunctival telangiectasia (HP:0000524)1.69301066
147Nephroblastoma (Wilms tumor) (HP:0002667)1.68544937
148Hemivertebrae (HP:0002937)1.67232876
149Failure to thrive in infancy (HP:0001531)1.65538888
150Overlapping toe (HP:0001845)1.65172911
151Abnormality of the duodenum (HP:0002246)1.64686303
152Irregular epiphyses (HP:0010582)1.63748785
153Exercise-induced muscle cramps (HP:0003710)1.62189538
154Atresia of the external auditory canal (HP:0000413)1.62060190
155Missing ribs (HP:0000921)1.61337152
156Polymicrogyria (HP:0002126)1.60661760
157Acute necrotizing encephalopathy (HP:0006965)1.60554561
158Anomalous pulmonary venous return (HP:0010772)1.60552625
159Delusions (HP:0000746)1.60491447
160Aplasia/Hypoplasia of the sacrum (HP:0008517)1.60128803
161Asplenia (HP:0001746)1.58571458
162Abnormality of vision evoked potentials (HP:0000649)1.58243387
163Spastic gait (HP:0002064)1.58105726
164Myelodysplasia (HP:0002863)1.58033570
165Muscle fiber splitting (HP:0003555)1.57586462
166Sex reversal (HP:0012245)1.57144905
167Abnormal sex determination (HP:0012244)1.57144905
168Exercise intolerance (HP:0003546)1.56570261
169Increased nuchal translucency (HP:0010880)1.56414112
170Intestinal atresia (HP:0011100)1.55809489
171Microglossia (HP:0000171)1.55622319
172Poor suck (HP:0002033)1.55289108
173Rimmed vacuoles (HP:0003805)1.55278153
174Aplasia/Hypoplasia of the macula (HP:0008059)1.55220011
175Abnormal auditory evoked potentials (HP:0006958)1.55214370
176Sparse eyelashes (HP:0000653)1.54915659
177High anterior hairline (HP:0009890)1.54813630
178Abnormal number of incisors (HP:0011064)1.54712261
179Emotional lability (HP:0000712)1.53967709
180Aplasia/Hypoplasia of the spleen (HP:0010451)1.53732429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.63725426
2MAP4K23.44337502
3MAP3K33.28218397
4TAOK13.09050464
5TRIM282.91942465
6WEE12.76596573
7TESK22.75781208
8CDK122.59146341
9UHMK12.25984140
10CDC72.23843670
11TTK2.23079973
12ICK2.22562524
13NEK12.13355373
14EPHA22.03477535
15MST41.99997220
16MAP2K31.89748808
17CDK71.88349106
18TYRO31.87985838
19AKT31.86165235
20ARAF1.83653540
21PLK11.82279765
22MAP3K51.80662203
23LMTK21.72438067
24PBK1.69374068
25TSSK61.64044372
26EPHA41.62597320
27ABL21.60112361
28TLK11.56766369
29PASK1.55939315
30CSNK1G31.51015413
31CDK191.50958014
32RPS6KB21.50257302
33AURKA1.49060484
34DYRK1A1.48823535
35DYRK31.47992800
36LIMK11.46329059
37BRSK11.46080755
38CHEK21.45676466
39DYRK21.36867090
40PRKD31.35810346
41NEK21.35203775
42DDR21.31502436
43LATS21.30766383
44ATR1.26162786
45CDK81.25747630
46CSNK1G11.24375010
47MAP2K71.23854141
48ADRBK21.18175965
49MATK1.15168091
50EPHB11.14249017
51CHEK11.11915896
52TNIK1.11630309
53VRK11.09551995
54MAP3K111.08605966
55PLK21.07245137
56CSNK1G21.06790497
57MYLK1.06231486
58BCKDK1.05338023
59MINK11.05152543
60DAPK11.04997420
61PAK41.04748507
62MKNK11.04473420
63STK161.02381320
64ALK1.01340985
65MAP3K80.99629672
66PKN10.98895879
67MAP3K90.97707526
68ZAK0.97619239
69NTRK30.94357597
70CDK20.94007111
71CDK140.93454358
72PLK30.92548793
73MAP3K120.92261807
74AURKB0.92076001
75CDK180.91847629
76PAK10.91409210
77PTK2B0.91066547
78EIF2AK10.90609734
79CDK150.89841755
80STK100.89547569
81GRK50.88802187
82HIPK20.88085163
83PHKG10.87863032
84PHKG20.87863032
85NTRK10.86764751
86CDK11A0.85602618
87PRKCI0.84819028
88SIK30.84181029
89SCYL20.82711013
90CSNK1A1L0.81279591
91EIF2AK30.80064195
92ILK0.79326354
93PRPF4B0.78590839
94PIM20.77074542
95SRPK10.77049274
96TNK20.76630442
97GRK60.74689191
98BRSK20.72847635
99CDK10.69565724
100TESK10.67133486
101MTOR0.66378656
102ATM0.66144017
103MAPK150.65461494
104MAPKAPK30.64659096
105CDK90.64308634
106ERBB40.63781465
107PRKD20.63451486
108NME20.61667121
109CDK40.60978217
110PINK10.60299742
111STK40.58931969
112BRAF0.58296080
113MAP3K40.56601886
114OBSCN0.56192021
115MAP3K10.56077023
116AKT20.54422524
117CSNK2A20.54280479
118MKNK20.54033074
119CCNB10.53935226
120STK390.53160633
121CAMK2G0.52053377
122BRD40.51498251
123CSNK1E0.50668486
124STK38L0.49812610
125CAMK2A0.49639656
126WNK30.49078410
127MAP3K60.48183714
128TAOK20.47969470
129MET0.47968655
130FGFR10.47444699
131WNK10.47426600
132MAPK100.45729270
133YES10.45549511
134CSNK2A10.45364521
135CAMK2D0.44794859
136CAMK2B0.43164712
137BMPR1B0.42692812
138BMX0.42434837
139NEK60.41719017
140KSR20.41411207
141BCR0.40848121
142RAF10.38977556
143PRKCG0.38934324
144MARK20.38511427
145MAPK140.38498540
146PLK40.38306265
147GSK3B0.38288493
148STK380.38134863
149MAPK70.37928104
150MAPK10.37639297
151VRK20.36808532
152NME10.34167775
153STK30.33684286
154KSR10.33683160
155CSNK1A10.31861715
156PRKD10.31669871

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.20084198
2Mismatch repair_Homo sapiens_hsa034304.18652298
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31665450
4Base excision repair_Homo sapiens_hsa034103.01149107
5Spliceosome_Homo sapiens_hsa030402.97840326
6RNA polymerase_Homo sapiens_hsa030202.84973804
7RNA transport_Homo sapiens_hsa030132.82121173
8Nucleotide excision repair_Homo sapiens_hsa034202.72858276
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63432820
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53987536
11Cell cycle_Homo sapiens_hsa041102.53221710
12Proteasome_Homo sapiens_hsa030502.40837724
13Homologous recombination_Homo sapiens_hsa034402.31751599
14Ribosome_Homo sapiens_hsa030102.10847673
15Fanconi anemia pathway_Homo sapiens_hsa034602.02266668
16Basal transcription factors_Homo sapiens_hsa030221.99944656
17One carbon pool by folate_Homo sapiens_hsa006701.90518814
18Propanoate metabolism_Homo sapiens_hsa006401.88008497
19mRNA surveillance pathway_Homo sapiens_hsa030151.80656990
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73694336
21* Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65706233
22Pyrimidine metabolism_Homo sapiens_hsa002401.60755322
23RNA degradation_Homo sapiens_hsa030181.60269555
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53398098
25Carbon metabolism_Homo sapiens_hsa012001.46456445
26Non-homologous end-joining_Homo sapiens_hsa034501.44915733
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44747190
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43185501
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30693250
30Hedgehog signaling pathway_Homo sapiens_hsa043401.30679777
31Oocyte meiosis_Homo sapiens_hsa041141.28419980
32Vitamin B6 metabolism_Homo sapiens_hsa007501.28385112
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25703835
34Fatty acid metabolism_Homo sapiens_hsa012121.25479157
35beta-Alanine metabolism_Homo sapiens_hsa004101.23977245
36Hippo signaling pathway_Homo sapiens_hsa043901.22731418
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17317743
38Basal cell carcinoma_Homo sapiens_hsa052171.16044523
39Pyruvate metabolism_Homo sapiens_hsa006201.13910516
40Steroid biosynthesis_Homo sapiens_hsa001001.08437361
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06372038
42p53 signaling pathway_Homo sapiens_hsa041151.03602421
43Purine metabolism_Homo sapiens_hsa002301.03467481
44Platelet activation_Homo sapiens_hsa046111.00522294
45Folate biosynthesis_Homo sapiens_hsa007900.95567989
46Notch signaling pathway_Homo sapiens_hsa043300.94006135
47Thyroid cancer_Homo sapiens_hsa052160.90336015
48Fructose and mannose metabolism_Homo sapiens_hsa000510.89896783
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88599375
50Biosynthesis of amino acids_Homo sapiens_hsa012300.88020011
51Protein export_Homo sapiens_hsa030600.87090184
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86827088
53Sulfur relay system_Homo sapiens_hsa041220.85067059
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82125207
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80641338
56Synaptic vesicle cycle_Homo sapiens_hsa047210.79622593
57Epstein-Barr virus infection_Homo sapiens_hsa051690.78114907
58GABAergic synapse_Homo sapiens_hsa047270.75469416
59Taste transduction_Homo sapiens_hsa047420.75175343
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74892908
61Viral carcinogenesis_Homo sapiens_hsa052030.73695782
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72413739
63Wnt signaling pathway_Homo sapiens_hsa043100.72205804
64Tight junction_Homo sapiens_hsa045300.71338324
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67378540
66Vibrio cholerae infection_Homo sapiens_hsa051100.67281762
67Ovarian steroidogenesis_Homo sapiens_hsa049130.67030736
68Colorectal cancer_Homo sapiens_hsa052100.66292120
69Bladder cancer_Homo sapiens_hsa052190.66192981
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65981425
71ECM-receptor interaction_Homo sapiens_hsa045120.65578594
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64234633
73mTOR signaling pathway_Homo sapiens_hsa041500.64054844
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.62832637
75Serotonergic synapse_Homo sapiens_hsa047260.60154769
76Regulation of autophagy_Homo sapiens_hsa041400.58770559
77Ether lipid metabolism_Homo sapiens_hsa005650.58740911
78Huntingtons disease_Homo sapiens_hsa050160.57670946
79Glycerolipid metabolism_Homo sapiens_hsa005610.56876761
80Fatty acid elongation_Homo sapiens_hsa000620.54054896
81HTLV-I infection_Homo sapiens_hsa051660.53772426
82Gap junction_Homo sapiens_hsa045400.52665559
83Linoleic acid metabolism_Homo sapiens_hsa005910.49947584
84N-Glycan biosynthesis_Homo sapiens_hsa005100.49919094
85Alcoholism_Homo sapiens_hsa050340.49456473
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47852107
87TGF-beta signaling pathway_Homo sapiens_hsa043500.47804073
88Olfactory transduction_Homo sapiens_hsa047400.47503607
89Sphingolipid metabolism_Homo sapiens_hsa006000.46413263
90MicroRNAs in cancer_Homo sapiens_hsa052060.46246832
91Peroxisome_Homo sapiens_hsa041460.45720532
92Pathways in cancer_Homo sapiens_hsa052000.44059793
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43919710
94Collecting duct acid secretion_Homo sapiens_hsa049660.43138203
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42858509
96Butanoate metabolism_Homo sapiens_hsa006500.41943362
97Parkinsons disease_Homo sapiens_hsa050120.39833859
98Nitrogen metabolism_Homo sapiens_hsa009100.39452922
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39410355
100Galactose metabolism_Homo sapiens_hsa000520.39137621
101Phototransduction_Homo sapiens_hsa047440.38625132
102Lysine degradation_Homo sapiens_hsa003100.37625269
103Arachidonic acid metabolism_Homo sapiens_hsa005900.37340872
104Arginine and proline metabolism_Homo sapiens_hsa003300.36940732
105Shigellosis_Homo sapiens_hsa051310.36652518
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36523796
107Circadian entrainment_Homo sapiens_hsa047130.36117745
108Oxidative phosphorylation_Homo sapiens_hsa001900.35553982
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34225000
110Dilated cardiomyopathy_Homo sapiens_hsa054140.34047848
111Fatty acid degradation_Homo sapiens_hsa000710.33824694
112AMPK signaling pathway_Homo sapiens_hsa041520.32882945
113ErbB signaling pathway_Homo sapiens_hsa040120.32833902
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32742843
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32711185
116Dopaminergic synapse_Homo sapiens_hsa047280.32202439
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32084080
118Endocytosis_Homo sapiens_hsa041440.31665746
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31561299
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31289858
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30394685
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30340794
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29497393
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.29478759
125Cardiac muscle contraction_Homo sapiens_hsa042600.28350379
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.26589250
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25157610
128Pentose phosphate pathway_Homo sapiens_hsa000300.25006718
129Melanogenesis_Homo sapiens_hsa049160.24404534
130Renal cell carcinoma_Homo sapiens_hsa052110.23761919
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23244971
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22411072
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22088501
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21659909
135Long-term depression_Homo sapiens_hsa047300.21404076
136Axon guidance_Homo sapiens_hsa043600.20367180
137Selenocompound metabolism_Homo sapiens_hsa004500.19946032
138Glutathione metabolism_Homo sapiens_hsa004800.18816612
139Metabolic pathways_Homo sapiens_hsa011000.18000551
140Adherens junction_Homo sapiens_hsa045200.17327313

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