FOCAD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.77299698
2cilium or flagellum-dependent cell motility (GO:0001539)4.21021249
3axonemal dynein complex assembly (GO:0070286)4.11068000
4cilium movement (GO:0003341)4.05988037
5nuclear pore complex assembly (GO:0051292)4.05580582
6nuclear pore organization (GO:0006999)3.90924482
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.66898340
8epithelial cilium movement (GO:0003351)3.61344157
9synaptic transmission, glutamatergic (GO:0035249)3.56681355
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52249312
11positive regulation of synapse maturation (GO:0090129)3.52118754
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.47412199
13intraciliary transport (GO:0042073)3.44539177
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44167093
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.43759672
16startle response (GO:0001964)3.39582782
17establishment of nucleus localization (GO:0040023)3.34268879
18glutamate receptor signaling pathway (GO:0007215)3.29370120
19replicative senescence (GO:0090399)3.27288952
20pre-miRNA processing (GO:0031054)3.20849085
21histone H4-K12 acetylation (GO:0043983)3.19992878
22paraxial mesoderm development (GO:0048339)3.19812007
23histone H4-K8 acetylation (GO:0043982)3.19229622
24histone H4-K5 acetylation (GO:0043981)3.19229622
25neuron-neuron synaptic transmission (GO:0007270)3.14316087
26regulation of synapse maturation (GO:0090128)3.12987193
27histone H3-K36 demethylation (GO:0070544)3.11169389
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10841245
29negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07552062
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06397889
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06215602
32regulation of glutamate receptor signaling pathway (GO:1900449)3.05994216
33regulation of helicase activity (GO:0051095)3.05541093
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.05171034
35regulation of sister chromatid cohesion (GO:0007063)2.95654285
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94245578
37positive regulation of dendritic spine morphogenesis (GO:0061003)2.94109791
38IMP biosynthetic process (GO:0006188)2.93586802
39cerebellar Purkinje cell differentiation (GO:0021702)2.92345176
40pore complex assembly (GO:0046931)2.91364571
41negative regulation of histone methylation (GO:0031061)2.91210893
42innervation (GO:0060384)2.90584663
43behavioral defense response (GO:0002209)2.89233221
44behavioral fear response (GO:0001662)2.89233221
45retinal ganglion cell axon guidance (GO:0031290)2.86569259
46negative regulation of DNA-dependent DNA replication (GO:2000104)2.85638207
47histone H3-K4 trimethylation (GO:0080182)2.85247683
48motile cilium assembly (GO:0044458)2.84788600
49regulation of telomere maintenance via telomerase (GO:0032210)2.84545491
50regulation of centriole replication (GO:0046599)2.84278360
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82209085
52glutamate secretion (GO:0014047)2.82104017
53positive regulation of DNA-dependent DNA replication (GO:2000105)2.82012416
54striatum development (GO:0021756)2.81980726
55G-protein coupled receptor internalization (GO:0002031)2.81236917
56locomotory exploration behavior (GO:0035641)2.76241015
57embryonic foregut morphogenesis (GO:0048617)2.74664403
58presynaptic membrane assembly (GO:0097105)2.74025719
59histone H3-K4 methylation (GO:0051568)2.74021226
60vocalization behavior (GO:0071625)2.71128580
61regulation of histone H3-K9 methylation (GO:0051570)2.71079996
62cilium assembly (GO:0042384)2.71046358
63synaptic vesicle endocytosis (GO:0048488)2.69956792
64regulation of telomere maintenance (GO:0032204)2.69382093
65protein localization to cilium (GO:0061512)2.68518442
66long-term memory (GO:0007616)2.67981122
67neurotransmitter-gated ion channel clustering (GO:0072578)2.66814235
68cilium organization (GO:0044782)2.66627401
69mitotic sister chromatid cohesion (GO:0007064)2.66301656
70apical protein localization (GO:0045176)2.66035756
71axonal fasciculation (GO:0007413)2.64826198
72regulation of DNA endoreduplication (GO:0032875)2.64748347
73membrane depolarization during action potential (GO:0086010)2.64712994
74neuron projection extension involved in neuron projection guidance (GO:1902284)2.63929774
75axon extension involved in axon guidance (GO:0048846)2.63929774
76regulation of histone H3-K27 methylation (GO:0061085)2.62934238
77histone H4-K16 acetylation (GO:0043984)2.62192461
78determination of adult lifespan (GO:0008340)2.61131326
79DNA replication initiation (GO:0006270)2.60476523
80microtubule-based movement (GO:0007018)2.59234697
81regulation of long-term neuronal synaptic plasticity (GO:0048169)2.57714323
82protein localization to synapse (GO:0035418)2.57013752
83regulation of synaptic transmission, glutamatergic (GO:0051966)2.56644530
84regulation of growth hormone secretion (GO:0060123)2.55288153
85left/right pattern formation (GO:0060972)2.54232883
86regulation of DNA damage checkpoint (GO:2000001)2.53459040
87regulation of excitatory postsynaptic membrane potential (GO:0060079)2.52833730
88nucleus localization (GO:0051647)2.52740559
89DNA strand renaturation (GO:0000733)2.52308856
90limb development (GO:0060173)2.51489663
91appendage development (GO:0048736)2.51489663
92regulation of neuronal synaptic plasticity (GO:0048168)2.51159310
93ventricular system development (GO:0021591)2.50760632
94positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50434900
95DNA geometric change (GO:0032392)2.49555679
96DNA duplex unwinding (GO:0032508)2.49160680
97cilium morphogenesis (GO:0060271)2.47922419
98regulation of mitotic spindle organization (GO:0060236)2.47864746
99pyrimidine nucleobase catabolic process (GO:0006208)2.47754562
100morphogenesis of an epithelial sheet (GO:0002011)2.47359645
101regulation of postsynaptic membrane potential (GO:0060078)2.47241177
102chemosensory behavior (GO:0007635)2.47236195
103cell communication by electrical coupling (GO:0010644)2.46498692
104regulation of DNA-dependent DNA replication (GO:0090329)2.46185598
105microtubule bundle formation (GO:0001578)2.46020029
106dorsal/ventral axis specification (GO:0009950)2.45899895
107protein polyglutamylation (GO:0018095)2.45759745
108fear response (GO:0042596)2.45239451
109calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44578406
110regulation of centrosome duplication (GO:0010824)2.43505115
111cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.43322299
112sister chromatid segregation (GO:0000819)2.43049696
113axoneme assembly (GO:0035082)2.42981574
114neuron recognition (GO:0008038)2.42185376
115cellular component assembly involved in morphogenesis (GO:0010927)2.40596145
116artery development (GO:0060840)2.40228241
117protein K6-linked ubiquitination (GO:0085020)2.40151943
118auditory receptor cell stereocilium organization (GO:0060088)2.40053790
119mitotic nuclear envelope disassembly (GO:0007077)2.39884617
120presynaptic membrane organization (GO:0097090)2.39741727
121atrial cardiac muscle cell action potential (GO:0086014)2.39595044
122negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.39126963
123regulation of MHC class I biosynthetic process (GO:0045343)2.38838439
124stress granule assembly (GO:0034063)2.38012087
125urinary tract smooth muscle contraction (GO:0014848)2.37832646
126inner ear receptor cell development (GO:0060119)2.37480014
127histone H3-K9 methylation (GO:0051567)2.36766828
128histone lysine methylation (GO:0034968)2.36391064
129kinetochore organization (GO:0051383)2.36333149
130righting reflex (GO:0060013)2.36215317
131mRNA splice site selection (GO:0006376)2.36004399
132auditory behavior (GO:0031223)2.35349349
133nucleobase biosynthetic process (GO:0046112)2.35205012
134transmission of nerve impulse (GO:0019226)2.35113640
135response to auditory stimulus (GO:0010996)2.34994786
136prepulse inhibition (GO:0060134)2.34936990
137mitotic sister chromatid segregation (GO:0000070)2.33337109
138DNA unwinding involved in DNA replication (GO:0006268)2.33284194
139regulation of centrosome cycle (GO:0046605)2.32923256
140synaptic vesicle maturation (GO:0016188)2.32888137
141gastrulation with mouth forming second (GO:0001702)2.32422325
142asymmetric protein localization (GO:0008105)2.32037306
143nonmotile primary cilium assembly (GO:0035058)2.31798509
144regulation of cilium movement (GO:0003352)2.31544117
145left/right axis specification (GO:0070986)2.28384305
146detection of calcium ion (GO:0005513)2.25636820
147establishment of monopolar cell polarity (GO:0061162)2.25466291
148establishment or maintenance of monopolar cell polarity (GO:0061339)2.25466291
149cerebral cortex development (GO:0021987)2.24534245
150NLS-bearing protein import into nucleus (GO:0006607)2.23732607
151double-strand break repair via nonhomologous end joining (GO:0006303)2.23020068
152non-recombinational repair (GO:0000726)2.23020068
153nucleobase catabolic process (GO:0046113)2.22979286
154regulation of cardioblast proliferation (GO:0003264)2.21388450
155regulation of secondary heart field cardioblast proliferation (GO:0003266)2.21388450
156axon extension (GO:0048675)2.17569419
157retinal rod cell development (GO:0046548)2.17074955
158glomerular epithelial cell development (GO:0072310)2.16125286
159microtubule-based transport (GO:0010970)2.15383687
160cytoskeleton-dependent intracellular transport (GO:0030705)2.14181270
161negative chemotaxis (GO:0050919)2.14167486
162ephrin receptor signaling pathway (GO:0048013)2.13509090
163smoothened signaling pathway (GO:0007224)2.12594617
164biotin metabolic process (GO:0006768)2.09855118
165establishment of planar polarity (GO:0001736)2.07475790
166establishment of tissue polarity (GO:0007164)2.07475790
167establishment of apical/basal cell polarity (GO:0035089)2.06248007
168lateral ventricle development (GO:0021670)2.05038241
169microtubule severing (GO:0051013)2.02895772
170myoblast fusion (GO:0007520)2.02475431
171regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.01365274
172olfactory bulb development (GO:0021772)2.00688054
173mesenchymal cell differentiation (GO:0048762)1.98778149
174negative regulation of chondrocyte differentiation (GO:0032331)1.97757448
175myelin assembly (GO:0032288)1.97644203
176lung-associated mesenchyme development (GO:0060484)1.96710875
177vesicle transport along microtubule (GO:0047496)1.95566716
178regulation of hippo signaling (GO:0035330)1.95178700
179pancreas development (GO:0031016)1.94289006
180peptidyl-lysine dimethylation (GO:0018027)1.94061613
181positive regulation of neurological system process (GO:0031646)1.93991622
182notochord development (GO:0030903)1.93250910
183hippo signaling (GO:0035329)1.93021872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.67285398
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.52786265
3GBX2_23144817_ChIP-Seq_PC3_Human4.43371003
4EZH2_22144423_ChIP-Seq_EOC_Human3.49404313
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.18059710
6SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.68397729
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.59122085
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48949618
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.47633713
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45033093
11TAF15_26573619_Chip-Seq_HEK293_Human2.43851910
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.37729586
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28987628
14DROSHA_22980978_ChIP-Seq_HELA_Human2.26448403
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22967556
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18207640
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15330325
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04013023
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96836789
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.94361606
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86203109
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84945583
23REST_21632747_ChIP-Seq_MESCs_Mouse1.81451717
24TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.80885774
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80494819
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74484039
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.74057551
28STAT3_23295773_ChIP-Seq_U87_Human1.71106114
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70303057
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.68868501
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65137401
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63045654
33SMAD4_21799915_ChIP-Seq_A2780_Human1.57881199
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57857934
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57186587
36FUS_26573619_Chip-Seq_HEK293_Human1.54146600
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53703832
38TCF4_23295773_ChIP-Seq_U87_Human1.44827412
39TBX3_20139965_ChIP-Seq_ESCs_Mouse1.43764087
40TBX3_20139965_ChIP-Seq_MESCs_Mouse1.41762944
41YAP1_20516196_ChIP-Seq_MESCs_Mouse1.40642564
42TP53_16413492_ChIP-PET_HCT116_Human1.39566579
43ZNF274_21170338_ChIP-Seq_K562_Hela1.39362938
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38001801
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36779479
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.36441801
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35261591
48AR_19668381_ChIP-Seq_PC3_Human1.33580236
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33369332
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.32765039
51EWS_26573619_Chip-Seq_HEK293_Human1.32273089
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32175750
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31795576
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29468023
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29468023
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29468023
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28207180
58ISL1_27105846_Chip-Seq_CPCs_Mouse1.26521489
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.26225109
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.26126125
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26110769
62RNF2_27304074_Chip-Seq_NSC_Mouse1.25476497
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24987722
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.23838712
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23196942
66STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22196071
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22154395
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21925390
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.21457935
70TP53_18474530_ChIP-ChIP_U2OS_Human1.21256120
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20979001
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20410847
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20336932
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.20116108
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.19071671
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18538836
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18182250
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.15977363
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15713528
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15713528
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15690817
82AR_25329375_ChIP-Seq_VCAP_Human1.13757453
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13274152
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12816865
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12713807
86RUNX2_22187159_ChIP-Seq_PCA_Human1.11660497
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.11584209
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.10441382
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10330762
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.09871762
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09807810
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.09728754
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09600643
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09311436
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.09273584
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09074828
97POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09065746
98P300_19829295_ChIP-Seq_ESCs_Human1.09036421
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08026844
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08026844
101EED_16625203_ChIP-ChIP_MESCs_Mouse1.07778709
102EZH2_27304074_Chip-Seq_ESCs_Mouse1.07372784
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07050906
104POU5F1_16518401_ChIP-PET_MESCs_Mouse1.06608982
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06159812
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05898853
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04889123
108NANOG_16518401_ChIP-PET_MESCs_Mouse1.04684555
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04134697
110SOX9_26525672_Chip-Seq_HEART_Mouse1.03784565
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03422892
112SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02084672
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01797322
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.01768609
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.01391369
116IGF1R_20145208_ChIP-Seq_DFB_Human1.01059535
117IRF1_19129219_ChIP-ChIP_H3396_Human1.00743127
118BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00672562
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00306143
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99294980
121NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96922876
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96502462
123AR_21572438_ChIP-Seq_LNCaP_Human0.96291646
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95760392
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95497604
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.95214342
127AHR_22903824_ChIP-Seq_MCF-7_Human0.95148998
128SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95093010
129SOX2_16153702_ChIP-ChIP_HESCs_Human0.94896888
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94119064
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93992244
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93932914
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.93642502
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93033775
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92809435
136CBP_20019798_ChIP-Seq_JUKART_Human0.92809435
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92764589
138POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92441860
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92336516
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.92303698
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91725205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.43705586
2MP0003111_abnormal_nucleus_morphology3.01691906
3MP0003787_abnormal_imprinting2.88496902
4MP0010094_abnormal_chromosome_stability2.75146304
5MP0005623_abnormal_meninges_morphology2.61568268
6MP0001188_hyperpigmentation2.56618513
7MP0002822_catalepsy2.41011924
8MP0003121_genomic_imprinting2.40051177
9MP0003635_abnormal_synaptic_transmissio2.39093913
10MP0000569_abnormal_digit_pigmentation2.31856060
11MP0008058_abnormal_DNA_repair2.28462864
12MP0008877_abnormal_DNA_methylation2.20546749
13MP0003123_paternal_imprinting2.20203267
14MP0005670_abnormal_white_adipose2.12097209
15MP0002063_abnormal_learning/memory/cond2.08471805
16MP0003283_abnormal_digestive_organ2.04025381
17MP0009745_abnormal_behavioral_response1.99932658
18MP0006292_abnormal_olfactory_placode1.84918213
19MP0008057_abnormal_DNA_replication1.84806243
20MP0003941_abnormal_skin_development1.80088597
21MP0002572_abnormal_emotion/affect_behav1.76951231
22MP0003937_abnormal_limbs/digits/tail_de1.76487811
23MP0002102_abnormal_ear_morphology1.74852233
24MP0003890_abnormal_embryonic-extraembry1.69638170
25MP0004133_heterotaxia1.69507578
26MP0001486_abnormal_startle_reflex1.68522561
27MP0002233_abnormal_nose_morphology1.64678134
28MP0009046_muscle_twitch1.62325143
29MP0005646_abnormal_pituitary_gland1.60455194
30MP0002735_abnormal_chemical_nociception1.59875064
31MP0001968_abnormal_touch/_nociception1.58842264
32MP0003880_abnormal_central_pattern1.56716046
33MP0003122_maternal_imprinting1.56249520
34MP0000383_abnormal_hair_follicle1.52647116
35MP0009780_abnormal_chondrocyte_physiolo1.50873347
36MP0010678_abnormal_skin_adnexa1.49030961
37MP0003693_abnormal_embryo_hatching1.45471755
38MP0004233_abnormal_muscle_weight1.42446220
39MP0008789_abnormal_olfactory_epithelium1.42080786
40MP0002736_abnormal_nociception_after1.41880491
41MP0002064_seizures1.39860461
42MP0005248_abnormal_Harderian_gland1.39830859
43MP0002697_abnormal_eye_size1.39764648
44MP0000537_abnormal_urethra_morphology1.36624636
45MP0003077_abnormal_cell_cycle1.33629402
46MP0000013_abnormal_adipose_tissue1.32859242
47MP0000566_synostosis1.32362900
48MP0006276_abnormal_autonomic_nervous1.32056421
49MP0010030_abnormal_orbit_morphology1.31070825
50MP0004270_analgesia1.31065977
51MP0010234_abnormal_vibrissa_follicle1.29337593
52MP0010307_abnormal_tumor_latency1.27465657
53MP0002272_abnormal_nervous_system1.21663029
54MP0004272_abnormal_basement_membrane1.21350516
55MP0002067_abnormal_sensory_capabilities1.19592515
56MP0003119_abnormal_digestive_system1.19582998
57MP0002938_white_spotting1.17385658
58MP0002653_abnormal_ependyma_morphology1.16470522
59MP0002557_abnormal_social/conspecific_i1.15629981
60MP0005551_abnormal_eye_electrophysiolog1.12950832
61MP0002734_abnormal_mechanical_nocicepti1.12839597
62MP0001502_abnormal_circadian_rhythm1.12266301
63MP0002184_abnormal_innervation1.12145910
64MP0005386_behavior/neurological_phenoty1.09958047
65MP0004924_abnormal_behavior1.09958047
66MP0000955_abnormal_spinal_cord1.07675819
67MP0003861_abnormal_nervous_system1.06161793
68MP0005423_abnormal_somatic_nervous1.04354216
69MP0006072_abnormal_retinal_apoptosis1.03258455
70MP0003385_abnormal_body_wall1.01829598
71MP0005187_abnormal_penis_morphology1.01801199
72MP0001501_abnormal_sleep_pattern1.01458231
73MP0002234_abnormal_pharynx_morphology1.01244345
74MP0010368_abnormal_lymphatic_system1.00974245
75MP0001286_abnormal_eye_development1.00481418
76MP0002837_dystrophic_cardiac_calcinosis1.00123020
77MP0009703_decreased_birth_body0.99159205
78MP0002160_abnormal_reproductive_system0.98765708
79MP0003045_fibrosis0.98573742
80MP0005499_abnormal_olfactory_system0.97342267
81MP0005394_taste/olfaction_phenotype0.97342267
82MP0002092_abnormal_eye_morphology0.97051112
83MP0005391_vision/eye_phenotype0.96632036
84MP0004134_abnormal_chest_morphology0.93184964
85MP0004145_abnormal_muscle_electrophysio0.91715646
86MP0004811_abnormal_neuron_physiology0.91625855
87MP0001299_abnormal_eye_distance/0.91611367
88MP0002152_abnormal_brain_morphology0.90818620
89MP0003942_abnormal_urinary_system0.90793687
90MP0000778_abnormal_nervous_system0.89228166
91MP0002085_abnormal_embryonic_tissue0.89013814
92MP0001293_anophthalmia0.88481267
93MP0002751_abnormal_autonomic_nervous0.88413451
94MP0002084_abnormal_developmental_patter0.88292692
95MP0003935_abnormal_craniofacial_develop0.88132526
96MP0000631_abnormal_neuroendocrine_gland0.88085178
97MP0008007_abnormal_cellular_replicative0.87542350
98MP0000534_abnormal_ureter_morphology0.87486166
99MP0000049_abnormal_middle_ear0.86234993
100MP0002909_abnormal_adrenal_gland0.85256999
101MP0005253_abnormal_eye_physiology0.84836793
102MP0001346_abnormal_lacrimal_gland0.84327579
103MP0002882_abnormal_neuron_morphology0.83514584
104MP0003879_abnormal_hair_cell0.83505547
105MP0005171_absent_coat_pigmentation0.82672802
106MP0003786_premature_aging0.82554419
107MP0000432_abnormal_head_morphology0.82514738
108MP0004197_abnormal_fetal_growth/weight/0.81605219
109MP0001672_abnormal_embryogenesis/_devel0.81195761
110MP0005380_embryogenesis_phenotype0.81195761
111MP0001440_abnormal_grooming_behavior0.80093872
112MP0005645_abnormal_hypothalamus_physiol0.79505017
113MP0002638_abnormal_pupillary_reflex0.77896239
114MP0005220_abnormal_exocrine_pancreas0.77621839
115MP0002116_abnormal_craniofacial_bone0.77421844
116MP0010352_gastrointestinal_tract_polyps0.77264102
117MP0004957_abnormal_blastocyst_morpholog0.77053605
118MP0002090_abnormal_vision0.76165147
119MP0005076_abnormal_cell_differentiation0.76129316
120MP0002075_abnormal_coat/hair_pigmentati0.75477336
121MP0008961_abnormal_basal_metabolism0.74352325
122MP0000427_abnormal_hair_cycle0.73940254
123MP0000026_abnormal_inner_ear0.73279942
124MP0000350_abnormal_cell_proliferation0.72600712
125MP0002081_perinatal_lethality0.72451146
126MP0001529_abnormal_vocalization0.72244495
127MP0001485_abnormal_pinna_reflex0.72219747
128MP0002086_abnormal_extraembryonic_tissu0.71524086
129MP0001984_abnormal_olfaction0.71348488
130MP0003632_abnormal_nervous_system0.70677800
131MP0002127_abnormal_cardiovascular_syste0.70633027
132MP0002269_muscular_atrophy0.70194534
133MP0002108_abnormal_muscle_morphology0.69656114
134MP0009672_abnormal_birth_weight0.69473850
135MP0003755_abnormal_palate_morphology0.69397581
136MP0002114_abnormal_axial_skeleton0.68430154
137MP0002752_abnormal_somatic_nervous0.67715651
138MP0001177_atelectasis0.67161484
139MP0003567_abnormal_fetal_cardiomyocyte0.66836521
140MP0000428_abnormal_craniofacial_morphol0.66459777

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.63200428
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.46691041
3Rhinitis (HP:0012384)3.98345031
4Chromsome breakage (HP:0040012)3.96147034
5Abnormal ciliary motility (HP:0012262)3.78105552
6Focal motor seizures (HP:0011153)3.76314177
7Abnormal respiratory motile cilium physiology (HP:0012261)3.66901610
8Febrile seizures (HP:0002373)3.46361705
9Anal stenosis (HP:0002025)3.45139580
10Abnormal respiratory motile cilium morphology (HP:0005938)3.42684016
11Abnormal respiratory epithelium morphology (HP:0012253)3.42684016
12Abnormality of the labia minora (HP:0012880)3.26179647
13Absent/shortened dynein arms (HP:0200106)3.24229376
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.24229376
15Occipital encephalocele (HP:0002085)3.09749910
16Astrocytoma (HP:0009592)2.95110481
17Abnormality of the astrocytes (HP:0100707)2.95110481
18Glioma (HP:0009733)2.88412287
19Tubulointerstitial nephritis (HP:0001970)2.84061885
20Pancreatic fibrosis (HP:0100732)2.82031974
21Focal seizures (HP:0007359)2.63951236
22Ependymoma (HP:0002888)2.62727302
23Nephronophthisis (HP:0000090)2.58384006
24Oligodactyly (hands) (HP:0001180)2.56438363
25True hermaphroditism (HP:0010459)2.53494222
26Urethral obstruction (HP:0000796)2.50099321
27Gait imbalance (HP:0002141)2.49999591
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.48923557
29Chronic bronchitis (HP:0004469)2.47638566
30Congenital primary aphakia (HP:0007707)2.42435677
31Medial flaring of the eyebrow (HP:0010747)2.41907299
32Medulloblastoma (HP:0002885)2.41097645
33Meckel diverticulum (HP:0002245)2.33827659
34Genital tract atresia (HP:0001827)2.32717830
35Birth length less than 3rd percentile (HP:0003561)2.29966498
36Bifid tongue (HP:0010297)2.27410165
37Vaginal atresia (HP:0000148)2.27197763
38Epileptic encephalopathy (HP:0200134)2.24611928
39Drooling (HP:0002307)2.22342676
40Neoplasm of the adrenal cortex (HP:0100641)2.22262534
41Abnormality of the carotid arteries (HP:0005344)2.20761566
42Tubular atrophy (HP:0000092)2.19328379
43Colon cancer (HP:0003003)2.18929644
44Abnormality of the ileum (HP:0001549)2.18605327
45Abnormality of chromosome stability (HP:0003220)2.17376224
46Obsessive-compulsive behavior (HP:0000722)2.17252015
47Acute lymphatic leukemia (HP:0006721)2.16932016
48Bronchiectasis (HP:0002110)2.16871334
49Nephrogenic diabetes insipidus (HP:0009806)2.15304597
50Elfin facies (HP:0004428)2.14312099
51Abnormality of the renal medulla (HP:0100957)2.14148559
52Congenital stationary night blindness (HP:0007642)2.12930506
53Cutaneous finger syndactyly (HP:0010554)2.12724720
54Postaxial foot polydactyly (HP:0001830)2.11735410
55Neoplasm of the oral cavity (HP:0100649)2.11568994
56Absent speech (HP:0001344)2.07029748
57Hepatoblastoma (HP:0002884)2.06795593
58Impaired vibration sensation in the lower limbs (HP:0002166)2.06141871
59Protruding tongue (HP:0010808)2.06062676
60Pancreatic cysts (HP:0001737)2.03612859
61Urinary urgency (HP:0000012)2.03005526
62Absent radius (HP:0003974)2.02814669
63Abnormality of the preputium (HP:0100587)2.01136992
64Renovascular hypertension (HP:0100817)1.98946843
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.98833981
66Aqueductal stenosis (HP:0002410)1.98659580
67Abnormality of midbrain morphology (HP:0002418)1.98411084
68Molar tooth sign on MRI (HP:0002419)1.98411084
69Gastroesophageal reflux (HP:0002020)1.98054470
70Oligodactyly (HP:0012165)1.97959334
71Impaired smooth pursuit (HP:0007772)1.97557552
72Poor coordination (HP:0002370)1.95582133
73Absent forearm bone (HP:0003953)1.94712036
74Aplasia involving forearm bones (HP:0009822)1.94712036
75Duplicated collecting system (HP:0000081)1.92260408
76Anencephaly (HP:0002323)1.91173897
77Anophthalmia (HP:0000528)1.90389008
78Abnormality of the lower motor neuron (HP:0002366)1.90293826
79Postaxial hand polydactyly (HP:0001162)1.90142207
80Abnormality of dentin (HP:0010299)1.90023170
81Abnormality of abdominal situs (HP:0011620)1.90007535
82Abdominal situs inversus (HP:0003363)1.90007535
83Excessive salivation (HP:0003781)1.89275772
84Volvulus (HP:0002580)1.89227290
85Gaze-evoked nystagmus (HP:0000640)1.88175272
86Ectopic kidney (HP:0000086)1.87090756
87Anal atresia (HP:0002023)1.86759548
88Aplasia/Hypoplasia of the sternum (HP:0006714)1.86687074
89Cutaneous syndactyly (HP:0012725)1.86172957
90Cystic liver disease (HP:0006706)1.85935631
91Skull defect (HP:0001362)1.85122299
92Duodenal stenosis (HP:0100867)1.84177796
93Small intestinal stenosis (HP:0012848)1.84177796
94Chronic hepatic failure (HP:0100626)1.81414302
95Abnormality of ocular smooth pursuit (HP:0000617)1.79970313
96Trigonocephaly (HP:0000243)1.79524740
97Nephroblastoma (Wilms tumor) (HP:0002667)1.78152951
98Intestinal atresia (HP:0011100)1.76860796
99Distal lower limb amyotrophy (HP:0008944)1.75974498
100Tubulointerstitial abnormality (HP:0001969)1.72605972
101Abnormality of the duodenum (HP:0002246)1.72331435
102Cerebellar dysplasia (HP:0007033)1.71657874
103Delayed puberty (HP:0000823)1.70591987
104Abnormality of the fingertips (HP:0001211)1.70517201
105Pointed chin (HP:0000307)1.70027523
106Shawl scrotum (HP:0000049)1.69892869
107Abnormality of the renal collecting system (HP:0004742)1.69835165
108Hip dysplasia (HP:0001385)1.69188757
109Abnormality of the corticospinal tract (HP:0002492)1.68376629
110Embryonal renal neoplasm (HP:0011794)1.67479544
111Labial hypoplasia (HP:0000066)1.65882609
112Distal lower limb muscle weakness (HP:0009053)1.65527871
113Flat cornea (HP:0007720)1.65201954
114Generalized hypopigmentation of hair (HP:0011358)1.64714372
115Progressive cerebellar ataxia (HP:0002073)1.63803923
116Breast aplasia (HP:0100783)1.63728325
117Preaxial hand polydactyly (HP:0001177)1.62931762
118Supernumerary spleens (HP:0009799)1.62870364
119Generalized tonic-clonic seizures (HP:0002069)1.62453146
120Breast hypoplasia (HP:0003187)1.62027623
121Abnormal pancreas size (HP:0012094)1.61937378
122Neoplasm of striated muscle (HP:0009728)1.61396634
123Mesomelia (HP:0003027)1.61231348
124Renal duplication (HP:0000075)1.61026068
125Micropenis (HP:0000054)1.60776442
126Bowel diverticulosis (HP:0005222)1.59829851
127Hyperinsulinemic hypoglycemia (HP:0000825)1.59329124
128Abnormality of DNA repair (HP:0003254)1.59317086
129Epileptiform EEG discharges (HP:0011182)1.57849384
130Truncal obesity (HP:0001956)1.57767050
131Prominent nose (HP:0000448)1.57716409
132Long eyelashes (HP:0000527)1.57594871
133Increased nuchal translucency (HP:0010880)1.57169645
134Broad foot (HP:0001769)1.56974867
135Abnormality of the renal cortex (HP:0011035)1.56255070
136Small hand (HP:0200055)1.56070205
137Septo-optic dysplasia (HP:0100842)1.55695902
138Hypoplastic female external genitalia (HP:0012815)1.55109759
139Omphalocele (HP:0001539)1.55071877
140Postural instability (HP:0002172)1.54664633
141Osteomalacia (HP:0002749)1.54652602
142Amblyopia (HP:0000646)1.54197175
143Narrow forehead (HP:0000341)1.54073918
144Congenital hepatic fibrosis (HP:0002612)1.53845537
145Papillary thyroid carcinoma (HP:0002895)1.53501358
146Abnormality of the labia (HP:0000058)1.53352243
147Megalocornea (HP:0000485)1.53245491
148Dysmetric saccades (HP:0000641)1.52697220
149Hypoplastic nipples (HP:0002557)1.52635219
150Biliary tract neoplasm (HP:0100574)1.52367682
151Abnormality of the nasal septum (HP:0000419)1.52263019
152Cortical dysplasia (HP:0002539)1.52138399
153Insidious onset (HP:0003587)1.51744283
154Termporal pattern (HP:0011008)1.51744283
155Vesicoureteral reflux (HP:0000076)1.50575412
156Rhabdomyosarcoma (HP:0002859)1.50440668
157Fair hair (HP:0002286)1.49891873
158EEG with generalized epileptiform discharges (HP:0011198)1.49040267
159Upper limb muscle weakness (HP:0003484)1.48963381
160Pelvic girdle muscle weakness (HP:0003749)1.48909980
161Esophageal atresia (HP:0002032)1.48879336
162Poor eye contact (HP:0000817)1.48194277
163Hyperventilation (HP:0002883)1.47841458
164Intellectual disability, moderate (HP:0002342)1.47743366
165Leiomyosarcoma (HP:0100243)1.47436308
166Specific learning disability (HP:0001328)1.47327145
167Facial cleft (HP:0002006)1.45078704
168Abnormal biliary tract physiology (HP:0012439)1.44980233
169Bile duct proliferation (HP:0001408)1.44980233
170Hand muscle atrophy (HP:0009130)1.43493558
171Hypsarrhythmia (HP:0002521)1.43446166
172Spastic diplegia (HP:0001264)1.42918096
173Sclerocornea (HP:0000647)1.42784131
174Short thorax (HP:0010306)1.42233112
175Oculomotor apraxia (HP:0000657)1.41589481
176Renal hypoplasia (HP:0000089)1.41381162
177Lower limb muscle weakness (HP:0007340)1.39540650
178Abnormality of the metopic suture (HP:0005556)1.39167729
179Dandy-Walker malformation (HP:0001305)1.38830460
180Hypoplastic labia majora (HP:0000059)1.38698977
181Broad-based gait (HP:0002136)1.38604277
182Overlapping toe (HP:0001845)1.38009030
183Disproportionate short-trunk short stature (HP:0003521)1.37709156
184Preaxial foot polydactyly (HP:0001841)1.36524858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.36433142
2EPHA43.72792901
3AKT33.38339643
4ZAK3.18563589
5TNIK2.85275006
6CDC72.45818461
7CDK122.20136208
8PKN22.14532025
9INSRR2.05998462
10BCR2.00700675
11EPHA22.00176743
12TTK1.97078295
13MAP3K41.82692290
14NEK11.76369784
15NTRK21.67130830
16BRD41.64780779
17MAP3K91.57585714
18CAMK1D1.54271177
19MAP4K21.47562105
20ATR1.45536088
21FRK1.44259709
22TRIM281.43803728
23BRSK21.42026454
24STK391.38459937
25CDK191.38282876
26SGK21.37281183
27OBSCN1.36159398
28MET1.32348905
29KSR11.27962628
30NEK61.27503840
31EIF2AK21.25570745
32PRPF4B1.24993025
33PINK11.24733030
34WNK31.20657174
35ERBB31.18027929
36STK381.17746251
37FLT31.16769991
38CHEK21.16760195
39STK38L1.15952205
40MKNK11.14432397
41CAMK1G1.13916181
42TSSK61.11921654
43TAOK21.11256100
44BMPR1B1.09110504
45TIE11.07936526
46LATS11.07918603
47SRPK11.07798912
48SGK31.06231689
49NEK21.05575801
50CSNK1G11.03987034
51CSNK1A1L1.02898294
52NEK90.96912989
53PAK30.96676009
54FER0.96449780
55EPHB20.95834458
56MAP2K70.94630515
57MKNK20.93638192
58PLK10.93545353
59CHEK10.91926311
60FGFR20.91205289
61CSNK1G30.90762929
62ATM0.89528206
63MAPK130.89504215
64ICK0.88733365
65CCNB10.88541051
66DAPK20.88126379
67DAPK10.88115299
68ALK0.87912029
69MAP3K130.87647014
70CAMKK20.85807399
71PHKG20.85104273
72PHKG10.85104273
73PLK30.83655923
74STK30.83129765
75CDC42BPA0.81336043
76MARK20.81085045
77PNCK0.80751006
78EEF2K0.80111595
79BRSK10.79329485
80NTRK10.78856340
81MAPK70.78720530
82MAP2K40.77887227
83MAP3K70.77610126
84RPS6KB20.77596144
85PLK40.77531704
86AKT20.77506728
87SGK10.77408920
88SIK30.76824434
89MTOR0.76761253
90LATS20.76298492
91PBK0.76171840
92CASK0.75376661
93PRKD30.74333472
94CDK20.73504671
95PRKCG0.73168517
96RPS6KB10.72988630
97STK240.72899508
98EPHA30.72620311
99MAPK100.72315575
100CAMK40.70625867
101CDK10.67693606
102CAMK10.67117631
103FGFR10.66592569
104PASK0.66349177
105GSK3B0.65504215
106MINK10.65123338
107PLK20.64642424
108PRKCE0.64491071
109CSNK1E0.63899661
110STK160.63653249
111DYRK30.62900251
112OXSR10.61767688
113CDK30.61282244
114CDK70.60464065
115MAPK140.59439101
116PRKAA10.59437733
117SGK4940.57134892
118SGK2230.57134892
119PDGFRA0.54819351
120PAK60.54180762
121PRKDC0.53530705
122MELK0.53517513
123DDR20.53470898
124RPS6KA30.53045478
125VRK10.52797350
126MARK10.52121128
127CDK50.51811064
128MST40.51543407
129CSNK1D0.51483840
130AURKB0.50971277
131TLK10.50690029
132TAF10.50150394
133MAPK80.49253898
134MAP3K60.48288104
135CSNK1G20.45209552
136BRAF0.44682933
137SIK20.44347485
138STK110.43890679
139CAMKK10.43143159
140RET0.42554140
141AKT10.42197338
142MAPK150.42073054
143PRKCB0.40786932
144ROCK20.40422580
145TGFBR10.40002844

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.18754234
2Circadian entrainment_Homo sapiens_hsa047132.18919872
3Fanconi anemia pathway_Homo sapiens_hsa034602.02868248
4Steroid biosynthesis_Homo sapiens_hsa001002.02569065
5One carbon pool by folate_Homo sapiens_hsa006701.99877407
6Long-term potentiation_Homo sapiens_hsa047201.95937620
7Glutamatergic synapse_Homo sapiens_hsa047241.95734671
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93956111
9Morphine addiction_Homo sapiens_hsa050321.93617313
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90780932
11Amphetamine addiction_Homo sapiens_hsa050311.90631066
12Olfactory transduction_Homo sapiens_hsa047401.88366145
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.79437946
14GABAergic synapse_Homo sapiens_hsa047271.77221580
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77168969
16Insulin secretion_Homo sapiens_hsa049111.74308991
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73345552
18Mismatch repair_Homo sapiens_hsa034301.66257418
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63469559
20DNA replication_Homo sapiens_hsa030301.58961743
21Vitamin B6 metabolism_Homo sapiens_hsa007501.56928923
22Calcium signaling pathway_Homo sapiens_hsa040201.53821500
23Propanoate metabolism_Homo sapiens_hsa006401.53630799
24Taste transduction_Homo sapiens_hsa047421.53550150
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48304109
26Synaptic vesicle cycle_Homo sapiens_hsa047211.47163749
27Alcoholism_Homo sapiens_hsa050341.45108939
28Non-homologous end-joining_Homo sapiens_hsa034501.43933915
29Homologous recombination_Homo sapiens_hsa034401.41340288
30Tight junction_Homo sapiens_hsa045301.40588768
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39831084
32Type II diabetes mellitus_Homo sapiens_hsa049301.37068329
33Dopaminergic synapse_Homo sapiens_hsa047281.36916163
34Cell cycle_Homo sapiens_hsa041101.36324290
35Cocaine addiction_Homo sapiens_hsa050301.34203653
36Phototransduction_Homo sapiens_hsa047441.33362564
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33004384
38ECM-receptor interaction_Homo sapiens_hsa045121.31451220
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30919412
40Salivary secretion_Homo sapiens_hsa049701.30421870
41Circadian rhythm_Homo sapiens_hsa047101.29343458
42Systemic lupus erythematosus_Homo sapiens_hsa053221.26884808
43Oocyte meiosis_Homo sapiens_hsa041141.25124396
44Lysine degradation_Homo sapiens_hsa003101.19825034
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19824668
46Cholinergic synapse_Homo sapiens_hsa047251.19322349
47Oxytocin signaling pathway_Homo sapiens_hsa049211.14462112
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14387786
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13238583
50mRNA surveillance pathway_Homo sapiens_hsa030151.12941127
51Base excision repair_Homo sapiens_hsa034101.10980308
52mTOR signaling pathway_Homo sapiens_hsa041501.09776946
53cAMP signaling pathway_Homo sapiens_hsa040241.07102314
54Selenocompound metabolism_Homo sapiens_hsa004501.04604724
55Renin secretion_Homo sapiens_hsa049241.04095671
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03575088
57RNA transport_Homo sapiens_hsa030131.03574168
58Butanoate metabolism_Homo sapiens_hsa006501.00409355
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98675989
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97431814
61Basal cell carcinoma_Homo sapiens_hsa052170.96738547
62Serotonergic synapse_Homo sapiens_hsa047260.96261774
63Inositol phosphate metabolism_Homo sapiens_hsa005620.95466212
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93711373
65Dilated cardiomyopathy_Homo sapiens_hsa054140.93034440
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92078858
67Gap junction_Homo sapiens_hsa045400.91510160
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90214047
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89392575
70Fatty acid metabolism_Homo sapiens_hsa012120.89307895
71GnRH signaling pathway_Homo sapiens_hsa049120.87981181
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86863645
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85927369
74ErbB signaling pathway_Homo sapiens_hsa040120.85558500
75Thyroid hormone synthesis_Homo sapiens_hsa049180.85159029
76beta-Alanine metabolism_Homo sapiens_hsa004100.84817451
77Pyruvate metabolism_Homo sapiens_hsa006200.84176130
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.82463934
79Long-term depression_Homo sapiens_hsa047300.82441828
80Wnt signaling pathway_Homo sapiens_hsa043100.81452662
81Melanogenesis_Homo sapiens_hsa049160.81391914
82Nucleotide excision repair_Homo sapiens_hsa034200.80911719
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79729103
84Protein export_Homo sapiens_hsa030600.79484871
85MicroRNAs in cancer_Homo sapiens_hsa052060.79483690
86Focal adhesion_Homo sapiens_hsa045100.79359008
87Estrogen signaling pathway_Homo sapiens_hsa049150.78679296
88RNA degradation_Homo sapiens_hsa030180.78264791
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77386426
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75988464
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74616374
92Glucagon signaling pathway_Homo sapiens_hsa049220.74014599
93Glioma_Homo sapiens_hsa052140.73375930
94Hippo signaling pathway_Homo sapiens_hsa043900.73188666
95Hedgehog signaling pathway_Homo sapiens_hsa043400.73068105
96Endometrial cancer_Homo sapiens_hsa052130.72240203
97Arginine and proline metabolism_Homo sapiens_hsa003300.71661112
98Dorso-ventral axis formation_Homo sapiens_hsa043200.71127622
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70136104
100Vibrio cholerae infection_Homo sapiens_hsa051100.70086392
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67662529
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.67522946
103Choline metabolism in cancer_Homo sapiens_hsa052310.67343822
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67183192
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66892827
106MAPK signaling pathway_Homo sapiens_hsa040100.66807211
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66067591
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64433173
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64360993
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.63446698
111Axon guidance_Homo sapiens_hsa043600.63339211
112Basal transcription factors_Homo sapiens_hsa030220.62993245
113Tryptophan metabolism_Homo sapiens_hsa003800.62766590
114Purine metabolism_Homo sapiens_hsa002300.62733357
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.62615540
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.61098768
117Ovarian steroidogenesis_Homo sapiens_hsa049130.60284247
118Phenylalanine metabolism_Homo sapiens_hsa003600.60276878
119p53 signaling pathway_Homo sapiens_hsa041150.59320498
120Proteoglycans in cancer_Homo sapiens_hsa052050.58786175
121Adherens junction_Homo sapiens_hsa045200.56896258
122TGF-beta signaling pathway_Homo sapiens_hsa043500.56882278
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.56310819
124Gastric acid secretion_Homo sapiens_hsa049710.55176114
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54909883
126Colorectal cancer_Homo sapiens_hsa052100.54095573
127Rap1 signaling pathway_Homo sapiens_hsa040150.51510374
128Melanoma_Homo sapiens_hsa052180.51215305
129AMPK signaling pathway_Homo sapiens_hsa041520.50233427
130Protein digestion and absorption_Homo sapiens_hsa049740.50001439
131Histidine metabolism_Homo sapiens_hsa003400.49635964
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49543080
133Sphingolipid metabolism_Homo sapiens_hsa006000.49304472
134Fatty acid biosynthesis_Homo sapiens_hsa000610.48880609
135N-Glycan biosynthesis_Homo sapiens_hsa005100.48630129
136Pancreatic secretion_Homo sapiens_hsa049720.47524759
137Insulin signaling pathway_Homo sapiens_hsa049100.46123488
138HTLV-I infection_Homo sapiens_hsa051660.45924501

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