FOLH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.06691436
2axon ensheathment in central nervous system (GO:0032291)8.06691436
3negative regulation of glycogen biosynthetic process (GO:0045719)6.78108098
4prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.32305578
5branching involved in prostate gland morphogenesis (GO:0060442)5.74824943
6alpha-linolenic acid metabolic process (GO:0036109)5.66269648
7auditory receptor cell differentiation (GO:0042491)5.65387729
8fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.36436728
9cerebellar Purkinje cell layer development (GO:0021680)5.31050319
10angiotensin maturation (GO:0002003)5.30994147
11L-serine metabolic process (GO:0006563)5.29935057
12beta-amyloid metabolic process (GO:0050435)5.23265181
13NADH metabolic process (GO:0006734)5.17609897
14negative regulation of glycogen metabolic process (GO:0070874)5.17544551
15positive regulation of histone deacetylation (GO:0031065)5.09847179
16insulin-like growth factor receptor signaling pathway (GO:0048009)5.01780520
17fatty acid elongation (GO:0030497)4.92195252
18copper ion transport (GO:0006825)4.84732431
19carnitine shuttle (GO:0006853)4.80266190
20aminoglycoside antibiotic metabolic process (GO:0030647)4.75934608
21myelin maintenance (GO:0043217)4.59456402
22drug transmembrane transport (GO:0006855)4.55774293
23phenol-containing compound catabolic process (GO:0019336)4.54785270
24regulation of endothelial cell chemotaxis (GO:2001026)4.48701665
25serine family amino acid biosynthetic process (GO:0009070)4.38735988
26cellular potassium ion homeostasis (GO:0030007)4.26869704
27fructose metabolic process (GO:0006000)4.26309495
28L-amino acid import (GO:0043092)4.26288396
29epithelial cell maturation (GO:0002070)4.17241572
30homocysteine metabolic process (GO:0050667)4.15909085
31linoleic acid metabolic process (GO:0043651)4.08702345
32neurotransmitter catabolic process (GO:0042135)4.05487757
33COPI coating of Golgi vesicle (GO:0048205)4.05438886
34Golgi transport vesicle coating (GO:0048200)4.05438886
35replicative senescence (GO:0090399)4.01831658
36organic cation transport (GO:0015695)4.01716094
37myelination (GO:0042552)3.98462822
38axon ensheathment (GO:0008366)3.96110410
39ensheathment of neurons (GO:0007272)3.96110410
40urate metabolic process (GO:0046415)3.92702150
41sodium ion export (GO:0071436)3.90020848
42regulation of receptor binding (GO:1900120)3.88982726
43fatty acid transmembrane transport (GO:1902001)3.86918533
44cerebellar granule cell differentiation (GO:0021707)3.85970848
45vascular endothelial growth factor signaling pathway (GO:0038084)3.84898565
46response to mercury ion (GO:0046689)3.84252592
47carnitine transmembrane transport (GO:1902603)3.81229341
48negative regulation of glucose import (GO:0046325)3.80967690
49intestinal epithelial cell development (GO:0060576)3.78873431
50amino acid import (GO:0043090)3.78010749
51proline biosynthetic process (GO:0006561)3.77643295
52positive regulation of protein deacetylation (GO:0090312)3.66526294
53epithelial cell differentiation involved in prostate gland development (GO:0060742)3.65195951
54aspartate family amino acid catabolic process (GO:0009068)3.64849521
55drug transport (GO:0015893)3.61347827
56alkaloid metabolic process (GO:0009820)3.57206410
57phosphate ion transport (GO:0006817)3.57098937
58positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.55171094
59response to methylmercury (GO:0051597)3.51555957
60metanephric tubule development (GO:0072170)3.48284468
61metanephric nephron tubule development (GO:0072234)3.48284468
62positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.46143304
63regulation of cholesterol metabolic process (GO:0090181)3.45979963
64neurotransmitter uptake (GO:0001504)3.45314425
65potassium ion import (GO:0010107)3.44692801
66nonribosomal peptide biosynthetic process (GO:0019184)3.41939955
67quaternary ammonium group transport (GO:0015697)3.41665020
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40938087
69very long-chain fatty acid metabolic process (GO:0000038)3.39146441
70fatty acid beta-oxidation (GO:0006635)3.38506198
71L-phenylalanine catabolic process (GO:0006559)3.36005589
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.36005589
73establishment of mitochondrion localization (GO:0051654)3.33142634
74short-chain fatty acid metabolic process (GO:0046459)3.31315040
75sulfur amino acid catabolic process (GO:0000098)3.27782450
76response to lead ion (GO:0010288)3.27446949
77ER overload response (GO:0006983)3.26957229
78positive regulation of cellular amine metabolic process (GO:0033240)3.26133024
79retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.25897630
80glutathione biosynthetic process (GO:0006750)3.25078439
81protein localization to synapse (GO:0035418)3.25035566
82prostate gland epithelium morphogenesis (GO:0060740)3.20216186
83creatine metabolic process (GO:0006600)3.18995514
84astrocyte differentiation (GO:0048708)3.18610629
85regulation of translational fidelity (GO:0006450)3.16922657
86glyoxylate metabolic process (GO:0046487)3.16487816
87excretion (GO:0007588)3.15829802
88import into cell (GO:0098657)3.14894275
89polyol transport (GO:0015791)3.14390672
90long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.13233971
91cellular sodium ion homeostasis (GO:0006883)3.11996451
92metanephric nephron epithelium development (GO:0072243)3.11556941
93C4-dicarboxylate transport (GO:0015740)3.09340045
94regulation of cholesterol biosynthetic process (GO:0045540)3.09096765
95zinc ion transmembrane transport (GO:0071577)3.07420463
96phosphate ion transmembrane transport (GO:0035435)3.06203794
97negative regulation of JUN kinase activity (GO:0043508)3.02162424
98long-chain fatty acid biosynthetic process (GO:0042759)3.01720369
99regulation of glucose import in response to insulin stimulus (GO:2001273)3.01428947
100coenzyme A metabolic process (GO:0015936)3.00241872
101fatty acid catabolic process (GO:0009062)2.99986661
102potassium ion homeostasis (GO:0055075)2.99035223
103lysine metabolic process (GO:0006553)2.98904544
104lysine catabolic process (GO:0006554)2.98904544
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.98026547
106L-phenylalanine metabolic process (GO:0006558)2.98026547
107oxaloacetate metabolic process (GO:0006107)2.97938911
108negative regulation of neurotransmitter transport (GO:0051589)2.96138639
109regulation of integrin-mediated signaling pathway (GO:2001044)2.96026670
110biotin metabolic process (GO:0006768)2.95751339
111regulation of protein homodimerization activity (GO:0043496)2.95361156
112long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.94076495
113very-low-density lipoprotein particle assembly (GO:0034379)2.91233655
114regulation of lipoprotein metabolic process (GO:0050746)2.90829092
115fatty-acyl-CoA biosynthetic process (GO:0046949)2.90717053
116Golgi to plasma membrane transport (GO:0006893)2.90397437
117peptide biosynthetic process (GO:0043043)2.89995755
118response to lipoprotein particle (GO:0055094)2.89180377
119presynaptic membrane organization (GO:0097090)2.87246006
120regulation of fatty acid beta-oxidation (GO:0031998)2.86960112
121regulation of histone deacetylation (GO:0031063)2.86349245
122thioester biosynthetic process (GO:0035384)2.86271763
123acyl-CoA biosynthetic process (GO:0071616)2.86271763
124fatty acid oxidation (GO:0019395)2.85701484
125zinc ion homeostasis (GO:0055069)2.85140045
126cellular response to electrical stimulus (GO:0071257)2.84618591
127metanephric epithelium development (GO:0072207)2.84200892
128branched-chain amino acid metabolic process (GO:0009081)2.83761179
129anterior/posterior axis specification, embryo (GO:0008595)2.83323949
130urea metabolic process (GO:0019627)2.82148171
131eye photoreceptor cell differentiation (GO:0001754)2.81909011
132photoreceptor cell differentiation (GO:0046530)2.81909011
133negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.81181628
134lipid oxidation (GO:0034440)2.80376835
135vitamin D metabolic process (GO:0042359)2.80098490
136triglyceride biosynthetic process (GO:0019432)2.79155758
137cell communication by electrical coupling (GO:0010644)2.79035398
138neurotransmitter biosynthetic process (GO:0042136)2.78405209
139carnitine metabolic process (GO:0009437)2.78203903
140membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78080059
141response to testosterone (GO:0033574)2.77966427
142endocrine hormone secretion (GO:0060986)2.77436204
143regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.75606040
144artery development (GO:0060840)2.75015621
145negative regulation of glucose transport (GO:0010829)2.74218055
146cholesterol biosynthetic process (GO:0006695)2.74038282
147diaphragm development (GO:0060539)2.73557308
148purine ribonucleotide transport (GO:0015868)2.73448718
149urea cycle (GO:0000050)2.73118113
150fatty-acyl-CoA metabolic process (GO:0035337)2.72769123
151branched-chain amino acid catabolic process (GO:0009083)2.71383395
152regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.70548882
153negative regulation of protein localization to cell surface (GO:2000009)2.70295651
154proline metabolic process (GO:0006560)2.70047916
155hair cell differentiation (GO:0035315)2.69963880
156positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.69817580
157presynaptic membrane assembly (GO:0097105)2.68936922
158dicarboxylic acid catabolic process (GO:0043649)2.68833841
159epoxygenase P450 pathway (GO:0019373)2.67410597
160desmosome organization (GO:0002934)2.67155976
161neutral lipid biosynthetic process (GO:0046460)2.65737436
162acylglycerol biosynthetic process (GO:0046463)2.65737436
163inner ear receptor cell differentiation (GO:0060113)2.65408762
164nucleotide transport (GO:0006862)2.65301803
165cysteine metabolic process (GO:0006534)2.65160660
166purine nucleotide transport (GO:0015865)2.64254956
167acetyl-CoA metabolic process (GO:0006084)2.59381259
168response to dietary excess (GO:0002021)2.57424063
169glycerol metabolic process (GO:0006071)2.57067614
170amino-acid betaine transport (GO:0015838)2.53879653
171carnitine transport (GO:0015879)2.53879653
172positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53459425
173negative regulation of response to reactive oxygen species (GO:1901032)2.53316898
174negative regulation of neurotransmitter secretion (GO:0046929)2.53030945
175response to phenylpropanoid (GO:0080184)2.52464615
176oligodendrocyte differentiation (GO:0048709)2.51610002
177L-serine transport (GO:0015825)2.50953690
178regulation of cardiac muscle cell contraction (GO:0086004)2.50218751
179renal absorption (GO:0070293)2.49564169
180gamma-aminobutyric acid transport (GO:0015812)2.49499166
181asymmetric protein localization (GO:0008105)2.48799418
182exogenous drug catabolic process (GO:0042738)2.48746173
183regulation of hydrogen peroxide-induced cell death (GO:1903205)2.48196773
184peripheral nervous system axon ensheathment (GO:0032292)2.48108377
185myelination in peripheral nervous system (GO:0022011)2.48108377
186iron ion import (GO:0097286)10.0072682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21909140_ChIP-Seq_LNCAP_Human7.45464173
2* CHD1_26751641_Chip-Seq_LNCaP_Human4.46505589
3FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human3.73298861
4ZNF263_19887448_ChIP-Seq_K562_Human3.58911035
5GBX2_23144817_ChIP-Seq_PC3_Human3.13846237
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.82870032
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.50512667
8CREB1_26743006_Chip-Seq_LNCaP_Human2.35488060
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32367860
10EZH2_22144423_ChIP-Seq_EOC_Human2.31636014
11RACK7_27058665_Chip-Seq_MCF-7_Human2.27358320
12FOXA1_25552417_ChIP-Seq_VCAP_Human2.25921606
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25818223
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.19736864
15* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18975115
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10989445
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08574612
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.02161185
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01413130
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01329621
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00833325
22FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.99258275
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95407637
24GATA6_25053715_ChIP-Seq_YYC3_Human1.94584549
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93112584
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89719301
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.89644149
28CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.89288735
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87799720
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86602611
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86602611
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85430214
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79540493
34* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75657690
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.73633415
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.68969344
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67438755
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65330834
39CLOCK_20551151_ChIP-Seq_293T_Human1.64580529
40TAF15_26573619_Chip-Seq_HEK293_Human1.61184450
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60330281
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59745443
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57138860
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.54927553
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53978061
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50293847
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48168446
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47194947
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.44719694
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.44266654
51EGR1_19032775_ChIP-ChIP_M12_Human1.43578161
52* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39586751
53KDM5A_27292631_Chip-Seq_BREAST_Human1.39092388
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.37862110
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37224633
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36910607
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36567025
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36363751
59P300_19829295_ChIP-Seq_ESCs_Human1.33802389
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.33559728
61DROSHA_22980978_ChIP-Seq_HELA_Human1.33376717
62LXR_22292898_ChIP-Seq_THP-1_Human1.33218360
63ER_23166858_ChIP-Seq_MCF-7_Human1.33041134
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32936003
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.32327166
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31868993
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30396685
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30055976
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29931449
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29875844
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27812930
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27812930
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27567739
74* AR_21572438_ChIP-Seq_LNCaP_Human1.26784499
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.25462975
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24009952
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24009612
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22947935
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22403226
80* RXR_22108803_ChIP-Seq_LS180_Human1.22160871
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22135909
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.22046460
83* VDR_22108803_ChIP-Seq_LS180_Human1.19982013
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.18879355
85* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18820461
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18474746
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.17927897
88ATF3_27146783_Chip-Seq_COLON_Human1.17878400
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17371820
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16869227
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16640457
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16640457
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16640457
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16055814
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15936666
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15651416
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14443023
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13774387
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13151878
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12514407
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12395519
102SMAD4_21799915_ChIP-Seq_A2780_Human1.12309377
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12130941
104SOX2_20726797_ChIP-Seq_SW620_Human1.11668567
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11611061
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11118454
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.10803716
108ERG_21242973_ChIP-ChIP_JURKAT_Human1.10468804
109GATA4_25053715_ChIP-Seq_YYC3_Human1.10353950
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09620191
111AHR_22903824_ChIP-Seq_MCF-7_Human1.09485831
112AR_25329375_ChIP-Seq_VCAP_Human1.07740766
113TP53_18474530_ChIP-ChIP_U2OS_Human1.07685942
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07492201
115ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07294953
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07123907
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.06604295
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06348015
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05869689
120GATA3_24758297_ChIP-Seq_MCF-7_Human1.05331473
121HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05218114
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05067713
123LXR_22158963_ChIP-Seq_LIVER_Mouse1.04676404
124P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04550241
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04320472
126* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03785491
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01565709
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01159019
129POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01146341
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00691246
131* STAT3_23295773_ChIP-Seq_U87_Human1.00392796
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00346307
133TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99512753
134ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99401332
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98930493
136MYC_22102868_ChIP-Seq_BL_Human0.97986029
137TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97518308
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97256366
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96890955
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.96623232
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96481008
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.96060244
143TCF7_22412390_ChIP-Seq_EML_Mouse0.95880486
144REST_21632747_ChIP-Seq_MESCs_Mouse0.95875276
145KDM2B_26808549_Chip-Seq_REH_Human0.95741505
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.95648023
147MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94693288
148SMAD3_21741376_ChIP-Seq_HESCs_Human0.94248320
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93537098
150BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92404193
151E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91407485
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.90821116
153NANOG_19829295_ChIP-Seq_ESCs_Human0.90275211
154SOX2_19829295_ChIP-Seq_ESCs_Human0.90275211
155RXR_22158963_ChIP-Seq_LIVER_Mouse0.90037318
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89803243
157RING1B_27294783_Chip-Seq_ESCs_Mouse0.89566948
158GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89487209
159GATA1_22025678_ChIP-Seq_K562_Human0.89413516
160SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89041020
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88487711
162KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87343143
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87306304
164RARB_27405468_Chip-Seq_BRAIN_Mouse0.87082195
165FOXA2_19822575_ChIP-Seq_HepG2_Human0.86577151
166TCF4_23295773_ChIP-Seq_U87_Human0.86321604
167* SOX2_21211035_ChIP-Seq_LN229_Gbm0.85811957
168HNF4A_19822575_ChIP-Seq_HepG2_Human0.85725418
169TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85114960
170LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85109297
171NANOG_18555785_Chip-Seq_ESCs_Mouse0.84903315
172MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84668818
173FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84640508
174EOMES_21245162_ChIP-Seq_HESCs_Human0.82770118
175KDM2B_26808549_Chip-Seq_K562_Human0.82496844
176HTT_18923047_ChIP-ChIP_STHdh_Human0.79698060
177YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78728588
178XRN2_22483619_ChIP-Seq_HELA_Human0.78118188
179ELF5_23300383_ChIP-Seq_T47D_Human0.77756797
180VDR_21846776_ChIP-Seq_THP-1_Human0.76299559
181FOXO3_23340844_ChIP-Seq_DLD1_Human0.74942533
182CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73944034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting5.14429298
2MP0004043_abnormal_pH_regulation4.97204737
3MP0002009_preneoplasia4.85307557
4MP0000537_abnormal_urethra_morphology4.42119379
5MP0010234_abnormal_vibrissa_follicle3.71380473
6MP0004233_abnormal_muscle_weight3.44660939
7MP0002166_altered_tumor_susceptibility3.42747196
8MP0003136_yellow_coat_color3.39472073
9MP0000920_abnormal_myelination3.28129442
10MP0003690_abnormal_glial_cell3.25669091
11MP0004885_abnormal_endolymph3.23776254
12MP0002822_catalepsy3.03382795
13MP0005360_urolithiasis3.03062851
14MP0003705_abnormal_hypodermis_morpholog2.89328650
15MP0005647_abnormal_sex_gland2.79536438
16MP0003315_abnormal_perineum_morphology2.78348547
17MP0005332_abnormal_amino_acid2.72334261
18MP0003195_calcinosis2.64755468
19MP0004270_analgesia2.63632997
20* MP0004858_abnormal_nervous_system2.62339248
21MP0003950_abnormal_plasma_membrane2.51565488
22MP0003329_amyloid_beta_deposits2.49900221
23MP0002006_tumorigenesis2.37243944
24MP0005377_hearing/vestibular/ear_phenot2.32491712
25MP0003878_abnormal_ear_physiology2.32491712
26MP0004264_abnormal_extraembryonic_tissu2.28083320
27MP0003880_abnormal_central_pattern2.24110969
28MP0004019_abnormal_vitamin_homeostasis2.23166938
29MP0005171_absent_coat_pigmentation2.19747219
30MP0005310_abnormal_salivary_gland2.03846466
31MP0001765_abnormal_ion_homeostasis2.03548942
32MP0009780_abnormal_chondrocyte_physiolo1.94291859
33MP0003183_abnormal_peptide_metabolism1.93301101
34MP0001666_abnormal_nutrient_absorption1.90197560
35MP0001485_abnormal_pinna_reflex1.89975725
36MP0005058_abnormal_lysosome_morphology1.89824325
37MP0005423_abnormal_somatic_nervous1.86886761
38MP0001486_abnormal_startle_reflex1.85455717
39MP0004947_skin_inflammation1.84002051
40MP0004742_abnormal_vestibular_system1.81760504
41MP0003634_abnormal_glial_cell1.79101463
42MP0005085_abnormal_gallbladder_physiolo1.76799084
43MP0001958_emphysema1.76320649
44MP0009643_abnormal_urine_homeostasis1.75365157
45MP0001873_stomach_inflammation1.72319628
46MP0003879_abnormal_hair_cell1.71731222
47MP0000627_abnormal_mammary_gland1.65597671
48MP0005670_abnormal_white_adipose1.60197565
49MP0002139_abnormal_hepatobiliary_system1.58764312
50MP0002064_seizures1.57717764
51MP0005365_abnormal_bile_salt1.53828548
52MP0004145_abnormal_muscle_electrophysio1.53660087
53MP0002272_abnormal_nervous_system1.51546416
54MP0009046_muscle_twitch1.49838783
55MP0003633_abnormal_nervous_system1.48899364
56MP0000613_abnormal_salivary_gland1.46344999
57MP0000538_abnormal_urinary_bladder1.44897811
58MP0005636_abnormal_mineral_homeostasis1.44530183
59MP0005409_darkened_coat_color1.39594697
60MP0004142_abnormal_muscle_tone1.39534836
61MP0004147_increased_porphyrin_level1.38037377
62MP0001881_abnormal_mammary_gland1.36920352
63MP0001440_abnormal_grooming_behavior1.36552228
64MP0001764_abnormal_homeostasis1.35778741
65MP0001756_abnormal_urination1.34195703
66MP0003631_nervous_system_phenotype1.34033365
67MP0002229_neurodegeneration1.33571564
68MP0002876_abnormal_thyroid_physiology1.32219378
69MP0003718_maternal_effect1.31859502
70MP0009384_cardiac_valve_regurgitation1.31711609
71MP0000604_amyloidosis1.29833847
72MP0003121_genomic_imprinting1.29544209
73MP0005410_abnormal_fertilization1.28340663
74MP0000778_abnormal_nervous_system1.22001393
75MP0003806_abnormal_nucleotide_metabolis1.20999254
76MP0003632_abnormal_nervous_system1.20887679
77MP0001905_abnormal_dopamine_level1.20708966
78MP0002734_abnormal_mechanical_nocicepti1.19943137
79MP0004782_abnormal_surfactant_physiolog1.19285178
80MP0001661_extended_life_span1.19182015
81MP0005584_abnormal_enzyme/coenzyme_acti1.18770328
82MP0001919_abnormal_reproductive_system1.18437784
83MP0002249_abnormal_larynx_morphology1.18038620
84MP0002136_abnormal_kidney_physiology1.16974578
85MP0003635_abnormal_synaptic_transmissio1.16916833
86MP0009745_abnormal_behavioral_response1.16714448
87MP0005666_abnormal_adipose_tissue1.12709758
88MP0002138_abnormal_hepatobiliary_system1.12258383
89MP0000566_synostosis1.11052066
90MP0001963_abnormal_hearing_physiology1.09839745
91MP0000516_abnormal_urinary_system1.09368915
92MP0005367_renal/urinary_system_phenotyp1.09368915
93MP0002067_abnormal_sensory_capabilities1.08942020
94MP0004859_abnormal_synaptic_plasticity1.08783225
95MP0005646_abnormal_pituitary_gland1.04501354
96MP0005551_abnormal_eye_electrophysiolog1.02266966
97MP0000377_abnormal_hair_follicle1.02234158
98MP0001529_abnormal_vocalization1.01501712
99MP0009840_abnormal_foam_cell0.99299120
100MP0003959_abnormal_lean_body0.98887318
101MP0002736_abnormal_nociception_after0.98259213
102MP0002063_abnormal_learning/memory/cond0.96804700
103MP0000747_muscle_weakness0.96785778
104MP0004185_abnormal_adipocyte_glucose0.96558048
105MP0002090_abnormal_vision0.95331444
106MP0008875_abnormal_xenobiotic_pharmacok0.94689847
107MP0005220_abnormal_exocrine_pancreas0.94592517
108MP0002098_abnormal_vibrissa_morphology0.94256977
109MP0003186_abnormal_redox_activity0.94025590
110MP0005395_other_phenotype0.93589874
111MP0003936_abnormal_reproductive_system0.93385584
112MP0002796_impaired_skin_barrier0.92364215
113MP0003941_abnormal_skin_development0.91995019
114MP0008260_abnormal_autophagy0.91667818
115MP0002066_abnormal_motor_capabilities/c0.91125542
116MP0003868_abnormal_feces_composition0.89328126
117MP0002118_abnormal_lipid_homeostasis0.88445461
118* MP0002572_abnormal_emotion/affect_behav0.87452863
119MP0001968_abnormal_touch/_nociception0.86229091
120MP0008569_lethality_at_weaning0.86014524
121MP0005535_abnormal_body_temperature0.85797877
122MP0005451_abnormal_body_composition0.85269181
123MP0010352_gastrointestinal_tract_polyps0.82419984
124MP0001177_atelectasis0.82061942
125MP0003011_delayed_dark_adaptation0.82048358
126MP0005187_abnormal_penis_morphology0.81626495
127MP0005375_adipose_tissue_phenotype0.81358133
128MP0002735_abnormal_chemical_nociception0.80670342
129MP0001970_abnormal_pain_threshold0.80547809
130MP0002882_abnormal_neuron_morphology0.79463668
131MP0000026_abnormal_inner_ear0.79360934
132* MP0000230_abnormal_systemic_arterial0.77554504
133MP0004134_abnormal_chest_morphology0.76030551
134MP0005386_behavior/neurological_phenoty0.74305417
135MP0004924_abnormal_behavior0.74305417
136MP0000534_abnormal_ureter_morphology0.71434323
137MP0001501_abnormal_sleep_pattern0.71081838
138MP0002733_abnormal_thermal_nociception0.69674219
139MP0002909_abnormal_adrenal_gland0.65887708
140MP0002168_other_aberrant_phenotype0.63180475
141MP0005167_abnormal_blood-brain_barrier0.63110817
142MP0001664_abnormal_digestion0.63056403
143MP0010678_abnormal_skin_adnexa0.61647867
144MP0003137_abnormal_impulse_conducting0.60223373
145MP0006138_congestive_heart_failure0.59640397
146MP0003938_abnormal_ear_development0.59627604
147MP0005319_abnormal_enzyme/_coenzyme0.59598230
148MP0002295_abnormal_pulmonary_circulatio0.59389426
149MP0000955_abnormal_spinal_cord0.59219877
150MP0002557_abnormal_social/conspecific_i0.58987905
151MP0004130_abnormal_muscle_cell0.58970792
152* MP0002752_abnormal_somatic_nervous0.57840796
153MP0001502_abnormal_circadian_rhythm0.57724815
154MP0001944_abnormal_pancreas_morphology0.57179724
155MP0000609_abnormal_liver_physiology0.54907710
156MP0001731_abnormal_postnatal_growth0.54246450
157MP0002078_abnormal_glucose_homeostasis0.52941361
158MP0003045_fibrosis0.50854251
159MP0004197_abnormal_fetal_growth/weight/0.49701948
160MP0003953_abnormal_hormone_level0.49619669
161MP0001216_abnormal_epidermal_layer0.49532430

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.12501401
2Sparse lateral eyebrow (HP:0005338)6.86028830
3Metabolic alkalosis (HP:0200114)6.58016299
4Hypokalemic alkalosis (HP:0001949)6.41537796
5Hypomagnesemia (HP:0002917)5.92760401
6Neonatal hypoglycemia (HP:0001998)5.91448207
7Abnormality of the axillary hair (HP:0100134)5.60316471
8Abnormality of secondary sexual hair (HP:0009888)5.60316471
9Polyuria (HP:0000103)5.18397630
10Abnormal urine output (HP:0012590)5.04197005
11Obstructive sleep apnea (HP:0002870)4.84440570
12Abnormality of magnesium homeostasis (HP:0004921)4.75630872
13Abnormality of renal excretion (HP:0011036)4.67960434
14Hyperactive renin-angiotensin system (HP:0000841)4.59952747
15Polydipsia (HP:0001959)4.54817795
16Abnormal drinking behavior (HP:0030082)4.54817795
17Neurofibrillary tangles (HP:0002185)4.51085146
18Prostate neoplasm (HP:0100787)4.21637857
19Abnormality of chloride homeostasis (HP:0011422)4.19756962
20Germ cell neoplasia (HP:0100728)4.17422130
21Lip pit (HP:0100267)4.15132612
22Gonadotropin excess (HP:0000837)3.98927409
23Hyperaldosteronism (HP:0000859)3.93584469
24Abnormality of the fingertips (HP:0001211)3.93145410
25Renal salt wasting (HP:0000127)3.90469563
26Abnormality of renin-angiotensin system (HP:0000847)3.88814797
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.80631075
28Alkalosis (HP:0001948)3.69818740
29Testicular atrophy (HP:0000029)3.69724094
30Azoospermia (HP:0000027)3.64042294
31Depressed nasal tip (HP:0000437)3.58549535
32Gout (HP:0001997)3.56789263
33Dysmetric saccades (HP:0000641)3.52930591
34Calf muscle hypertrophy (HP:0008981)3.52323122
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.49293681
36Hyperammonemia (HP:0001987)3.48322125
37Overgrowth (HP:0001548)3.45097415
38Aplasia involving bones of the upper limbs (HP:0009823)3.43125906
39Aplasia of the phalanges of the hand (HP:0009802)3.43125906
40Aplasia involving bones of the extremities (HP:0009825)3.43125906
41Proximal tubulopathy (HP:0000114)3.40721276
42Degeneration of the lateral corticospinal tracts (HP:0002314)3.35479383
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.35479383
44Cerebral inclusion bodies (HP:0100314)3.32552894
45Hyperglycinuria (HP:0003108)3.24365633
46Tetany (HP:0001281)3.23845116
47Abnormal auditory evoked potentials (HP:0006958)3.16376156
48Confusion (HP:0001289)3.15961463
49Abnormality of glycine metabolism (HP:0010895)3.12422072
50Abnormality of serine family amino acid metabolism (HP:0010894)3.12422072
51Aplasia of the musculature (HP:0100854)3.04648129
52Muscle hypertrophy of the lower extremities (HP:0008968)3.01867993
53Advanced eruption of teeth (HP:0006288)2.98570897
54Intrahepatic cholestasis (HP:0001406)2.94616677
55Amelogenesis imperfecta (HP:0000705)2.92105746
56Hypokalemia (HP:0002900)2.90434234
57Limb hypertonia (HP:0002509)2.88166426
58Fat malabsorption (HP:0002630)2.87697382
59Death in childhood (HP:0003819)2.71264761
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69620836
61Shallow orbits (HP:0000586)2.65700790
62Anal stenosis (HP:0002025)2.65089040
63Long palpebral fissure (HP:0000637)2.64553436
64Hyperuricemia (HP:0002149)2.62250555
65Increased purine levels (HP:0004368)2.62250555
66Glossoptosis (HP:0000162)2.59713507
67Ketoacidosis (HP:0001993)2.56256307
68Supranuclear gaze palsy (HP:0000605)2.55391952
69Segmental peripheral demyelination/remyelination (HP:0003481)2.53254687
70Renal tubular acidosis (HP:0001947)2.48038213
71Abnormality of potassium homeostasis (HP:0011042)2.46364780
72Abnormality of the corticospinal tract (HP:0002492)2.46344146
73Onion bulb formation (HP:0003383)2.45348675
74Flat acetabular roof (HP:0003180)2.44401630
75Bulbar palsy (HP:0001283)2.39454198
76Hypothermia (HP:0002045)2.38051930
77Testicular neoplasm (HP:0010788)2.37489839
78Potter facies (HP:0002009)2.35065844
79Facial shape deformation (HP:0011334)2.35065844
80Axonal loss (HP:0003447)2.34778366
81Bifid scrotum (HP:0000048)2.33633369
82Abnormal spermatogenesis (HP:0008669)2.32638174
83Right ventricular cardiomyopathy (HP:0011663)2.32225277
84Hypercalciuria (HP:0002150)2.31102504
85Abnormality of glutamine family amino acid metabolism (HP:0010902)2.28866954
86Abnormality of homocysteine metabolism (HP:0010919)2.28730444
87Homocystinuria (HP:0002156)2.28730444
88Malnutrition (HP:0004395)2.27529685
89Pheochromocytoma (HP:0002666)2.23685983
90Broad face (HP:0000283)2.20906394
91Synostosis involving the elbow (HP:0003938)2.19976797
92Humeroradial synostosis (HP:0003041)2.19976797
93Macroorchidism (HP:0000053)2.18191547
94Sensorimotor neuropathy (HP:0007141)2.18107386
95Hypoglycemic coma (HP:0001325)2.17128154
96Precocious puberty (HP:0000826)2.15393877
97Metabolic acidosis (HP:0001942)2.13737366
98Seborrheic dermatitis (HP:0001051)2.13645162
99Generalized aminoaciduria (HP:0002909)2.12069854
100Abnormality of binocular vision (HP:0011514)2.10524169
101Diplopia (HP:0000651)2.10524169
102Glycosuria (HP:0003076)2.10335439
103Abnormality of urine glucose concentration (HP:0011016)2.10335439
104Abnormality of purine metabolism (HP:0004352)2.10193851
105Abnormal pupillary function (HP:0007686)2.09566274
106Peripheral hypomyelination (HP:0007182)2.07841649
107Vascular calcification (HP:0004934)2.07739029
108Hypophosphatemic rickets (HP:0004912)2.07512575
109Abnormal eating behavior (HP:0100738)2.07458121
110Laryngomalacia (HP:0001601)2.07419650
111Abnormality of the parathyroid morphology (HP:0011766)2.07206648
112Rickets (HP:0002748)2.06860435
113Abnormality of renal resorption (HP:0011038)2.06782546
114Hyperglycinemia (HP:0002154)2.06383484
115Sleep apnea (HP:0010535)2.05380492
116Ketosis (HP:0001946)2.02582438
117Absent hair (HP:0002298)2.02427357
118Clumsiness (HP:0002312)2.01382300
119Skin pits (HP:0100276)2.01270078
120Exercise-induced myalgia (HP:0003738)1.99998973
121Hypoplasia of the odontoid process (HP:0003311)1.99867944
122Paraparesis (HP:0002385)1.99740559
123Parakeratosis (HP:0001036)1.99595373
124Enlarged kidneys (HP:0000105)1.99363091
125Hypoplastic left heart (HP:0004383)1.99072625
126Impulsivity (HP:0100710)1.97745669
127Intention tremor (HP:0002080)1.97484453
128Widely patent fontanelles and sutures (HP:0004492)1.96535921
129Limb ataxia (HP:0002070)1.96448509
130Dysmetria (HP:0001310)1.94185336
131Breast hypoplasia (HP:0003187)1.92504682
132Hypoplasia of the iris (HP:0007676)1.91743009
133Neuroendocrine neoplasm (HP:0100634)1.89866471
134Papilledema (HP:0001085)1.89752924
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89312345
136Hemiparesis (HP:0001269)1.87902524
137Abnormality of the middle phalanges of the toes (HP:0010183)1.87179108
138Broad nasal tip (HP:0000455)1.86056666
139Nephrocalcinosis (HP:0000121)1.85497384
140Morphological abnormality of the inner ear (HP:0011390)1.84459062
141Abnormally folded helix (HP:0008544)1.84381485
142Pseudobulbar signs (HP:0002200)1.82486475
143Cardiovascular calcification (HP:0011915)1.81596670
144Spastic paraparesis (HP:0002313)1.80704723
145Abnormal urine phosphate concentration (HP:0012599)1.79904880
146Megalencephaly (HP:0001355)1.79142343
147Abnormality of permanent molar morphology (HP:0011071)1.78587557
148Abnormality of the dental root (HP:0006486)1.78587557
149Taurodontia (HP:0000679)1.78587557
150Choanal stenosis (HP:0000452)1.76869121
151Abnormality of sulfur amino acid metabolism (HP:0004339)1.74182633
152Leukodystrophy (HP:0002415)1.73282639
153Hyperphosphaturia (HP:0003109)1.72922777
154Partial agenesis of the corpus callosum (HP:0001338)1.72873089
155Blue sclerae (HP:0000592)1.72125160
156Abnormality of fatty-acid metabolism (HP:0004359)1.71630069
157Delayed epiphyseal ossification (HP:0002663)1.71567235
158Abnormality of glycolysis (HP:0004366)1.71464586
159Tubulointerstitial fibrosis (HP:0005576)1.71193750
160Abnormality of the dental pulp (HP:0006479)1.71183002
161Stridor (HP:0010307)1.70407022
162Thin bony cortex (HP:0002753)1.70177117
163Abnormality of the columella (HP:0009929)1.69740625
164Abnormality of molar morphology (HP:0011070)1.69247174
165Abnormality of molar (HP:0011077)1.69247174
166Split foot (HP:0001839)1.68859502
167Hyperlipoproteinemia (HP:0010980)1.68585866
168Overfolded helix (HP:0000396)1.68126030
169Cerebral hemorrhage (HP:0001342)1.67761243
170Ankle clonus (HP:0011448)1.66765630
171Short hallux (HP:0010109)1.66697355
172Termporal pattern (HP:0011008)1.66372668
173Neonatal death (HP:0003811)1.66199728
174Severe short stature (HP:0003510)1.63176250
175Congenital stationary night blindness (HP:0007642)1.62729475
176Absent hand (HP:0004050)1.61088372
177Steatorrhea (HP:0002570)1.60794710
178Aplasia/Hypoplasia of the sternum (HP:0006714)1.60475526
179Abnormality of the prostate (HP:0008775)1.59195022
180Thoracic kyphosis (HP:0002942)1.58887250
181Abnormality of the thoracic spine (HP:0100711)1.58479534
182Fasciculations (HP:0002380)1.58349809
183Abnormality of vitamin metabolism (HP:0100508)1.57642049
184Hyperphosphatemia (HP:0002905)1.57533108
185Prolonged neonatal jaundice (HP:0006579)1.57502028
186Hyperthyroidism (HP:0000836)1.57471595
187Truncal ataxia (HP:0002078)1.57251933
188Shawl scrotum (HP:0000049)1.56623094
189Neoplasm of the adrenal cortex (HP:0100641)1.56550941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.23027976
2OXSR16.46843680
3STK396.19525602
4WNK45.79298710
5WNK34.03374594
6TNK23.38020003
7EEF2K3.16477188
8TRIB32.89892641
9TAF12.72099438
10ICK2.45417269
11SMG12.44545422
12EPHB12.32081718
13WNK12.15842160
14SGK4942.13052623
15SGK2232.13052623
16MAPKAPK52.08372754
17PRKD31.83617005
18GRK11.75633916
19MET1.68121355
20FGFR21.62186211
21NEK61.61196793
22TNIK1.59855416
23PKN11.58358030
24MST41.54265281
25NTRK11.49974131
26BCR1.44897170
27TESK21.43170586
28SIK11.38092995
29PKN21.34185836
30EPHA41.24551710
31PHKG21.24168733
32PHKG11.24168733
33MAPK121.23803434
34PBK1.21545144
35CASK1.21332601
36EIF2AK11.13153961
37PDK21.03650411
38BRSK21.00439618
39ERN10.99834770
40CAMKK20.99328478
41CAMK1G0.98207888
42CAMK2B0.97406449
43LATS10.97163343
44PINK10.96056584
45LMTK20.95978204
46PNCK0.93021578
47ROCK20.91707480
48BCKDK0.89811186
49VRK20.89137112
50PDK40.88742689
51PDK30.88742689
52MAPK130.87766383
53PAK30.86343544
54UHMK10.85262192
55PRKCE0.84315535
56PIK3CA0.83281122
57MAPK70.81688791
58MUSK0.81633253
59NEK90.81628108
60PDPK10.80965655
61PAK60.78524223
62SCYL20.78440835
63FGR0.77758334
64PRKD20.76428677
65CAMK2G0.76262759
66NTRK20.74771439
67CAMKK10.74507039
68CDK70.74186723
69CDK190.73539170
70TAOK10.71898595
71CAMK2D0.69978046
72EPHA20.69776930
73MARK10.68723207
74EPHA30.68253020
75MARK20.68245732
76CAMK2A0.67434271
77CDK50.67162214
78LATS20.65062602
79MTOR0.64995436
80PRKD10.64934824
81CAMK1D0.64425066
82GSK3A0.63033551
83LIMK10.60234718
84PAK20.59541150
85SGK10.57338405
86MAPKAPK30.56975513
87CDK120.55986069
88CSNK1G10.55399755
89CSNK1G20.54773927
90PRKCG0.54664827
91PRKCQ0.54090604
92SGK20.54044148
93NUAK10.52255303
94NTRK30.52142733
95IRAK20.51461793
96PTK60.51438083
97MAP3K20.50869789
98PDK10.50854254
99HIPK20.50526208
100ERBB40.50425147
101CSNK1A1L0.49958999
102PRKCH0.49815146
103CSNK1G30.48866273
104SGK30.46903132
105TIE10.46114099
106MAP2K40.43525362
107PRKAA20.42901896
108MST1R0.41961160
109CDK140.41462780
110KSR20.40153127
111TYRO30.40095175
112PRKACB0.39452884
113MAP3K130.39363843
114CDK150.38729566
115STK380.38566247
116PTK2B0.38453204
117PRKACA0.38413468
118CSNK1A10.37818823
119MAP2K70.37786754
120MINK10.37416502
121FER0.37410262
122ILK0.37196308
123TSSK60.35728310
124FYN0.34481275
125CDK180.33633346
126MAPK150.33632466
127DYRK1A0.33425624
128PRKCA0.32659303
129CLK10.32082214
130PRKCZ0.31203305
131PRKAA10.31179666
132ARAF0.30522137
133BRSK10.30469168
134INSRR0.30051969
135IRAK30.30042076
136BMX0.30014417
137CDK11A0.29416643
138LRRK20.29293323
139RPS6KA20.29227361
140RPS6KB20.28860895
141CSNK1D0.28687938
142DYRK20.28403450
143PRKG10.28283254
144MAP3K40.27904690
145RET0.26675726
146NEK10.26631141
147CSNK1E0.21433009
148MAP3K10.20639781
149MAP3K110.20541083
150DAPK30.17634878
151FGFR40.17370234
152MAP3K90.17207431
153CDC42BPA0.16223112
154ERBB20.15894605
155ACVR1B0.13565885
156YES10.12973418
157AKT10.11891203
158RPS6KB10.10595894
159DAPK10.09668638
160ALK0.09415971
161TAOK30.09268392
162CDK60.09020141
163MAPK140.08067150
164PDGFRA0.06840919
165MAPK100.06361524
166CDK90.06278332
167AURKA0.05522875

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.93374401
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.63064985
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.21453589
4Fatty acid elongation_Homo sapiens_hsa000623.01259164
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.82012528
6Steroid biosynthesis_Homo sapiens_hsa001002.70472530
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56501128
8Butanoate metabolism_Homo sapiens_hsa006502.48566547
9Propanoate metabolism_Homo sapiens_hsa006402.47607498
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41102768
11Sulfur metabolism_Homo sapiens_hsa009201.98358449
12Fatty acid metabolism_Homo sapiens_hsa012121.95219055
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84578740
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70767274
15Fructose and mannose metabolism_Homo sapiens_hsa000511.69663509
16Prion diseases_Homo sapiens_hsa050201.68313064
17Peroxisome_Homo sapiens_hsa041461.68239335
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66793159
19Fatty acid degradation_Homo sapiens_hsa000711.65017439
20Collecting duct acid secretion_Homo sapiens_hsa049661.64246199
21Pyruvate metabolism_Homo sapiens_hsa006201.62791382
22Mineral absorption_Homo sapiens_hsa049781.56948210
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51454088
24Bile secretion_Homo sapiens_hsa049761.48301410
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46255737
26Ether lipid metabolism_Homo sapiens_hsa005651.45923745
27Biosynthesis of amino acids_Homo sapiens_hsa012301.38550011
28Histidine metabolism_Homo sapiens_hsa003401.36563639
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.29734321
30Arginine and proline metabolism_Homo sapiens_hsa003301.27176174
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25637707
32PPAR signaling pathway_Homo sapiens_hsa033201.23679446
33Sphingolipid metabolism_Homo sapiens_hsa006001.21299691
34Gastric acid secretion_Homo sapiens_hsa049711.19381451
35beta-Alanine metabolism_Homo sapiens_hsa004101.17781490
36Cocaine addiction_Homo sapiens_hsa050301.16111992
37Glycerolipid metabolism_Homo sapiens_hsa005611.12627996
38Fatty acid biosynthesis_Homo sapiens_hsa000611.11307154
39Caffeine metabolism_Homo sapiens_hsa002321.06408888
40* Vitamin digestion and absorption_Homo sapiens_hsa049771.06225278
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.06224002
42Glutathione metabolism_Homo sapiens_hsa004801.04958486
43Oxidative phosphorylation_Homo sapiens_hsa001901.04707382
44Amphetamine addiction_Homo sapiens_hsa050311.03339838
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01431379
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98831679
47Prostate cancer_Homo sapiens_hsa052150.96443692
48AMPK signaling pathway_Homo sapiens_hsa041520.95805968
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94619564
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94078674
51Tryptophan metabolism_Homo sapiens_hsa003800.91493472
52Fat digestion and absorption_Homo sapiens_hsa049750.88721336
53GABAergic synapse_Homo sapiens_hsa047270.88484439
54Protein digestion and absorption_Homo sapiens_hsa049740.87414352
55Endometrial cancer_Homo sapiens_hsa052130.86791596
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86698264
57Salivary secretion_Homo sapiens_hsa049700.86627742
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84226824
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83433118
60mTOR signaling pathway_Homo sapiens_hsa041500.83208299
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82200654
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82058038
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81383768
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80710565
65Insulin resistance_Homo sapiens_hsa049310.77417133
66Lysosome_Homo sapiens_hsa041420.77227997
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74087702
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73258958
69Vitamin B6 metabolism_Homo sapiens_hsa007500.72889293
70Arginine biosynthesis_Homo sapiens_hsa002200.72037100
71* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70397712
72Carbon metabolism_Homo sapiens_hsa012000.70320293
73Glutamatergic synapse_Homo sapiens_hsa047240.69623663
74Glucagon signaling pathway_Homo sapiens_hsa049220.69162418
75Thyroid hormone synthesis_Homo sapiens_hsa049180.68790854
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68687892
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64454487
78Parkinsons disease_Homo sapiens_hsa050120.64436504
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64394134
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62869032
81Insulin signaling pathway_Homo sapiens_hsa049100.62448592
82Alzheimers disease_Homo sapiens_hsa050100.60567301
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59455227
84Cardiac muscle contraction_Homo sapiens_hsa042600.59180050
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58157625
86Lysine degradation_Homo sapiens_hsa003100.57780273
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.55796869
88Linoleic acid metabolism_Homo sapiens_hsa005910.55679252
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54415047
90Morphine addiction_Homo sapiens_hsa050320.53850204
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.53686257
92Renin-angiotensin system_Homo sapiens_hsa046140.53498231
93Pancreatic secretion_Homo sapiens_hsa049720.52103734
94Folate biosynthesis_Homo sapiens_hsa007900.50884050
95Arachidonic acid metabolism_Homo sapiens_hsa005900.50392372
96Estrogen signaling pathway_Homo sapiens_hsa049150.50273318
97Selenocompound metabolism_Homo sapiens_hsa004500.49611025
98ABC transporters_Homo sapiens_hsa020100.49274950
99Dorso-ventral axis formation_Homo sapiens_hsa043200.49003705
100* Metabolic pathways_Homo sapiens_hsa011000.48406422
101Thyroid cancer_Homo sapiens_hsa052160.47583088
102Renin secretion_Homo sapiens_hsa049240.46470820
103Choline metabolism in cancer_Homo sapiens_hsa052310.45838230
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44567697
105Serotonergic synapse_Homo sapiens_hsa047260.43768712
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43669383
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42881940
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.42720716
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.42408601
110Axon guidance_Homo sapiens_hsa043600.42408031
111Insulin secretion_Homo sapiens_hsa049110.41670738
112Synaptic vesicle cycle_Homo sapiens_hsa047210.41639081
113Dopaminergic synapse_Homo sapiens_hsa047280.41429016
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.41016441
115VEGF signaling pathway_Homo sapiens_hsa043700.38651223
116Retinol metabolism_Homo sapiens_hsa008300.38148336
117Long-term potentiation_Homo sapiens_hsa047200.37242501
118Tyrosine metabolism_Homo sapiens_hsa003500.36834440
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.36527309
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36188149
121Vibrio cholerae infection_Homo sapiens_hsa051100.35993452
122Chemical carcinogenesis_Homo sapiens_hsa052040.35967887
123Hepatitis C_Homo sapiens_hsa051600.35931629
124Gap junction_Homo sapiens_hsa045400.34357470
125Phenylalanine metabolism_Homo sapiens_hsa003600.34142115
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32891339
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32776837
128Circadian entrainment_Homo sapiens_hsa047130.31595949
129Other glycan degradation_Homo sapiens_hsa005110.31322729
130Notch signaling pathway_Homo sapiens_hsa043300.31214571
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31025013
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30978709
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30512236
134Starch and sucrose metabolism_Homo sapiens_hsa005000.28908331
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.26184497
136Ovarian steroidogenesis_Homo sapiens_hsa049130.25756173

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