FOLH1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.16224095
2drug catabolic process (GO:0042737)9.09639087
3epoxygenase P450 pathway (GO:0019373)8.68451583
4omega-hydroxylase P450 pathway (GO:0097267)8.14965073
5glyoxylate metabolic process (GO:0046487)7.87781946
6ethanol oxidation (GO:0006069)7.35601511
7regulation of fibrinolysis (GO:0051917)6.81936418
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.80947018
9L-phenylalanine catabolic process (GO:0006559)6.80947018
10complement activation, alternative pathway (GO:0006957)6.62506515
11negative regulation of fibrinolysis (GO:0051918)6.62064113
12regulation of protein activation cascade (GO:2000257)6.41596474
13urea metabolic process (GO:0019627)6.36958543
14drug metabolic process (GO:0017144)6.31981549
15oxidative demethylation (GO:0070989)6.30111761
16L-phenylalanine metabolic process (GO:0006558)6.20252973
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.20252973
18bile acid biosynthetic process (GO:0006699)6.14820312
19regulation of complement activation (GO:0030449)6.03268677
20ethanol metabolic process (GO:0006067)5.92342413
21cellular glucuronidation (GO:0052695)5.79627856
22nitrogen cycle metabolic process (GO:0071941)5.77620774
23bile acid metabolic process (GO:0008206)5.72907215
24uronic acid metabolic process (GO:0006063)5.67217994
25glucuronate metabolic process (GO:0019585)5.67217994
26peptidyl-glutamic acid carboxylation (GO:0017187)5.48400691
27protein carboxylation (GO:0018214)5.48400691
28fibrinolysis (GO:0042730)5.36788815
29urea cycle (GO:0000050)5.34939287
30aromatic amino acid family catabolic process (GO:0009074)5.31526039
31phenylpropanoid metabolic process (GO:0009698)5.26295266
32blood coagulation, intrinsic pathway (GO:0007597)5.18413379
33bile acid and bile salt transport (GO:0015721)5.13950616
34S-adenosylmethionine metabolic process (GO:0046500)5.08853647
35alkaloid metabolic process (GO:0009820)4.95389233
36serine family amino acid catabolic process (GO:0009071)4.83144553
37regulation of triglyceride catabolic process (GO:0010896)4.68192216
38negative regulation of cholesterol transport (GO:0032375)4.64351502
39negative regulation of sterol transport (GO:0032372)4.64351502
40protein activation cascade (GO:0072376)4.59738600
41complement activation, classical pathway (GO:0006958)4.54011972
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.50327320
43imidazole-containing compound metabolic process (GO:0052803)4.46956997
44complement activation (GO:0006956)4.46941408
45glycine metabolic process (GO:0006544)4.28427096
46regulation of plasminogen activation (GO:0010755)4.17852230
47negative regulation of blood coagulation (GO:0030195)4.16103689
48negative regulation of hemostasis (GO:1900047)4.16103689
49opsonization (GO:0008228)4.13323068
50amino-acid betaine metabolic process (GO:0006577)4.11237793
51hormone catabolic process (GO:0042447)4.10909735
52acylglycerol homeostasis (GO:0055090)4.10183898
53triglyceride homeostasis (GO:0070328)4.10183898
54arginine metabolic process (GO:0006525)4.02858017
55fat-soluble vitamin biosynthetic process (GO:0042362)4.01471815
56high-density lipoprotein particle remodeling (GO:0034375)4.00393691
57indole-containing compound catabolic process (GO:0042436)3.98707392
58indolalkylamine catabolic process (GO:0046218)3.98707392
59tryptophan catabolic process (GO:0006569)3.98707392
60phospholipid efflux (GO:0033700)3.97594860
61plasma lipoprotein particle remodeling (GO:0034369)3.96688600
62protein-lipid complex remodeling (GO:0034368)3.96688600
63macromolecular complex remodeling (GO:0034367)3.96688600
64tyrosine metabolic process (GO:0006570)3.85841040
65acute-phase response (GO:0006953)3.78883026
66negative regulation of wound healing (GO:0061045)3.76294719
67negative regulation of coagulation (GO:0050819)3.75450463
68alpha-amino acid catabolic process (GO:1901606)3.74545642
69regulation of humoral immune response (GO:0002920)3.71363874
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.71267027
71xenobiotic metabolic process (GO:0006805)3.70616556
72cholesterol efflux (GO:0033344)3.70543971
73flavonoid metabolic process (GO:0009812)3.69368254
74negative regulation of lipase activity (GO:0060192)3.68936050
75heme transport (GO:0015886)3.68435279
76reverse cholesterol transport (GO:0043691)3.66514448
77regulation of cholesterol esterification (GO:0010872)3.62282190
78serine family amino acid metabolic process (GO:0009069)3.58960779
79negative regulation of protein activation cascade (GO:2000258)3.52666341
80killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.51569479
81disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.51569479
82phospholipid homeostasis (GO:0055091)3.51433561
83glutamate metabolic process (GO:0006536)3.50298095
84cellular ketone body metabolic process (GO:0046950)3.48088639
85primary alcohol metabolic process (GO:0034308)3.47839138
86primary alcohol catabolic process (GO:0034310)3.44570938
87very-low-density lipoprotein particle assembly (GO:0034379)3.42013560
88intestinal cholesterol absorption (GO:0030299)3.41621829
89steroid catabolic process (GO:0006706)3.39545720
90aromatic amino acid family metabolic process (GO:0009072)3.37358250
91cytolysis (GO:0019835)3.36253682
92response to mercury ion (GO:0046689)3.29697252
93tryptophan metabolic process (GO:0006568)3.28470404
94sodium-independent organic anion transport (GO:0043252)3.27527098
95positive regulation of triglyceride lipase activity (GO:0061365)3.26708009
96positive regulation of lipoprotein lipase activity (GO:0051006)3.26708009
97cellular amino acid catabolic process (GO:0009063)3.26423999
98monocarboxylic acid catabolic process (GO:0072329)3.23523662
99cysteine metabolic process (GO:0006534)3.18268444
100intestinal absorption (GO:0050892)3.16190603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.45763567
2EGR1_23403033_ChIP-Seq_LIVER_Mouse5.34886320
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.30468923
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.62763835
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.53207634
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.19204005
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.24226119
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.01025908
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.93253877
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.60047359
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30606921
12PIAS1_25552417_ChIP-Seq_VCAP_Human2.12036473
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.03941760
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98741463
15AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.86768120
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81149071
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.80686255
18FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.79846089
19HNF4A_19822575_ChIP-Seq_HepG2_Human1.75591676
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64744309
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59112295
22CDX2_20551321_ChIP-Seq_CACO-2_Human1.59043097
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56910635
24FOXA1_25552417_ChIP-Seq_VCAP_Human1.53231934
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.51828213
26HTT_18923047_ChIP-ChIP_STHdh_Human1.50063000
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49891743
28GATA4_25053715_ChIP-Seq_YYC3_Human1.49771831
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45205771
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42666694
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42577194
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42013033
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37662515
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35475468
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30772156
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27193426
37ER_23166858_ChIP-Seq_MCF-7_Human1.21915930
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21436166
39BCAT_22108803_ChIP-Seq_LS180_Human1.16697533
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15995835
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12335244
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10799164
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.06813714
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.05664199
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99097656
46ESR1_21235772_ChIP-Seq_MCF-7_Human0.96995721
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96434643
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94559298
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93721534
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90564391
51NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90564391
52AR_20517297_ChIP-Seq_VCAP_Human0.89972192
53GATA6_25053715_ChIP-Seq_YYC3_Human0.89056974
54CBP_21632823_ChIP-Seq_H3396_Human0.88199591
55IGF1R_20145208_ChIP-Seq_DFB_Human0.86397144
56SOX2_20726797_ChIP-Seq_SW620_Human0.84544971
57GBX2_23144817_ChIP-Seq_PC3_Human0.79931155
58DROSHA_22980978_ChIP-Seq_HELA_Human0.79179615
59TAF15_26573619_Chip-Seq_HEK293_Human0.77496404
60CDX2_22108803_ChIP-Seq_LS180_Human0.77431591
61ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76154777
62GATA3_24758297_ChIP-Seq_MCF-7_Human0.75513320
63TP53_18474530_ChIP-ChIP_U2OS_Human0.75326729
64FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75087753
65CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74765086
66IRF1_19129219_ChIP-ChIP_H3396_Human0.71648132
67SOX2_21211035_ChIP-Seq_LN229_Human0.71548469
68KAP1_22055183_ChIP-Seq_ESCs_Mouse0.70545375
69EZH2_27294783_Chip-Seq_ESCs_Mouse0.69783839
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.69156644
71ZFP57_27257070_Chip-Seq_ESCs_Mouse0.69125243
72IRF8_22096565_ChIP-ChIP_GC-B_Human0.68905144
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68638754
74STAT3_23295773_ChIP-Seq_U87_Human0.68393836
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68207107
76RUNX2_22187159_ChIP-Seq_PCA_Human0.67253530
77AR_21909140_ChIP-Seq_LNCAP_Human0.67249926
78HNFA_21074721_ChIP-Seq_CACO-2_Human0.67207022
79P53_21459846_ChIP-Seq_SAOS-2_Human0.66787441
80CEBPB_22108803_ChIP-Seq_LS180_Human0.66456606
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.65590334
82FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.63767172
83NANOG_19829295_ChIP-Seq_ESCs_Human0.63687465
84SOX2_19829295_ChIP-Seq_ESCs_Human0.63687465
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.63355648
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.62510323
87SMAD4_21741376_ChIP-Seq_EPCs_Human0.62443909
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.62372003
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.62086429
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.62012451
91RXRA_24833708_ChIP-Seq_LIVER_Mouse0.62010414
92AR_25329375_ChIP-Seq_VCAP_Human0.61871075
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61582928
94ERG_20517297_ChIP-Seq_VCAP_Human0.59602758
95ERA_21632823_ChIP-Seq_H3396_Human0.59486252
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.59364225
97PHF8_20622853_ChIP-Seq_HELA_Human0.58247840
98TCF4_22108803_ChIP-Seq_LS180_Human0.57991016
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57931031
100NFYA_21822215_ChIP-Seq_K562_Human0.57577879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.84125619
2MP0005360_urolithiasis6.42482810
3MP0005085_abnormal_gallbladder_physiolo6.41723529
4MP0005365_abnormal_bile_salt5.52865644
5MP0008875_abnormal_xenobiotic_pharmacok5.45468608
6MP0001666_abnormal_nutrient_absorption4.13294272
7MP0003195_calcinosis3.86021965
8MP0003252_abnormal_bile_duct3.63716573
9MP0002138_abnormal_hepatobiliary_system3.20760500
10MP0003868_abnormal_feces_composition3.01956218
11MP0010329_abnormal_lipoprotein_level2.92652299
12MP0003191_abnormal_cellular_cholesterol2.40283404
13MP0005451_abnormal_body_composition2.37562891
14MP0003806_abnormal_nucleotide_metabolis2.36519856
15MP0009840_abnormal_foam_cell2.35760818
16MP0005332_abnormal_amino_acid2.34236943
17MP0004019_abnormal_vitamin_homeostasis2.07081500
18MP0009697_abnormal_copulation2.06687994
19MP0001764_abnormal_homeostasis2.04230980
20MP0002876_abnormal_thyroid_physiology1.92123302
21MP0002118_abnormal_lipid_homeostasis1.80240116
22MP0000609_abnormal_liver_physiology1.70295107
23MP0003011_delayed_dark_adaptation1.47421155
24MP0000537_abnormal_urethra_morphology1.26949062
25MP0009053_abnormal_anal_canal1.14884751
26MP0005584_abnormal_enzyme/coenzyme_acti1.14418413
27MP0005319_abnormal_enzyme/_coenzyme1.07658750
28MP0002249_abnormal_larynx_morphology1.06851317
29MP0009643_abnormal_urine_homeostasis1.06747228
30MP0004043_abnormal_pH_regulation1.05863466
31MP0003183_abnormal_peptide_metabolism1.04713099
32MP0003315_abnormal_perineum_morphology1.02188338
33MP0005636_abnormal_mineral_homeostasis0.95359799
34MP0000598_abnormal_liver_morphology0.93513922
35MP0004858_abnormal_nervous_system0.89556953
36MP0010368_abnormal_lymphatic_system0.87877646
37MP0005395_other_phenotype0.87304475
38MP0005187_abnormal_penis_morphology0.86568429
39MP0000566_synostosis0.82034223
40MP0009642_abnormal_blood_homeostasis0.78328115
41MP0000604_amyloidosis0.78010393
42MP0008872_abnormal_physiological_respon0.74455694
43MP0002971_abnormal_brown_adipose0.73492455
44MP0003879_abnormal_hair_cell0.73014118
45MP0005376_homeostasis/metabolism_phenot0.72293278
46MP0002009_preneoplasia0.71905038
47MP0001440_abnormal_grooming_behavior0.71094140
48MP0002168_other_aberrant_phenotype0.70648787
49MP0003656_abnormal_erythrocyte_physiolo0.69290153
50MP0005670_abnormal_white_adipose0.67365738
51MP0000538_abnormal_urinary_bladder0.65956402
52MP0001881_abnormal_mammary_gland0.65505487
53MP0005367_renal/urinary_system_phenotyp0.65434086
54MP0000516_abnormal_urinary_system0.65434086
55MP0001756_abnormal_urination0.65206742
56MP0002282_abnormal_trachea_morphology0.63860318
57MP0005408_hypopigmentation0.62846364
58MP0005535_abnormal_body_temperature0.62690951
59MP0003186_abnormal_redox_activity0.62300412
60MP0005647_abnormal_sex_gland0.62184342
61MP0004782_abnormal_surfactant_physiolog0.60873962
62MP0005166_decreased_susceptibility_to0.60712424
63MP0003718_maternal_effect0.60200137
64MP0008469_abnormal_protein_level0.59673692
65MP0002078_abnormal_glucose_homeostasis0.59401082
66MP0002736_abnormal_nociception_after0.57073024
67MP0009763_increased_sensitivity_to0.57048001
68MP0005646_abnormal_pituitary_gland0.55190269
69MP0001661_extended_life_span0.54957510
70MP0004742_abnormal_vestibular_system0.50581178
71MP0001485_abnormal_pinna_reflex0.49722969
72MP0005645_abnormal_hypothalamus_physiol0.49619770
73MP0005334_abnormal_fat_pad0.48524408
74MP0003959_abnormal_lean_body0.48480971
75MP0010386_abnormal_urinary_bladder0.48341527
76MP0002136_abnormal_kidney_physiology0.47260157
77MP0003690_abnormal_glial_cell0.45524049
78MP0003638_abnormal_response/metabolism_0.43271993
79MP0008874_decreased_physiological_sensi0.42613037
80MP0009764_decreased_sensitivity_to0.40796633
81MP0001664_abnormal_digestion0.40534926
82MP0002822_catalepsy0.40398041
83MP0003953_abnormal_hormone_level0.40353997
84MP0002102_abnormal_ear_morphology0.37863062
85MP0005448_abnormal_energy_balance0.37832788
86MP0005266_abnormal_metabolism0.37062643
87MP0003705_abnormal_hypodermis_morpholog0.36829481
88MP0003329_amyloid_beta_deposits0.35313543
89MP0005551_abnormal_eye_electrophysiolog0.34585634
90MP0009115_abnormal_fat_cell0.33984489
91MP0001919_abnormal_reproductive_system0.33765639
92MP0004924_abnormal_behavior0.33713326
93MP0005386_behavior/neurological_phenoty0.33713326
94MP0003075_altered_response_to0.32875350
95MP0000026_abnormal_inner_ear0.31825120
96MP0000249_abnormal_blood_vessel0.31052553
97MP0000639_abnormal_adrenal_gland0.30915219
98MP0004147_increased_porphyrin_level0.29859436
99MP0003866_abnormal_defecation0.26764953
100MP0002697_abnormal_eye_size0.26054111

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.72588165
2Deep venous thrombosis (HP:0002625)8.93158364
3Complement deficiency (HP:0004431)8.52087778
4Prolonged partial thromboplastin time (HP:0003645)7.84854996
5Hypobetalipoproteinemia (HP:0003563)7.00013992
6Abnormality of complement system (HP:0005339)6.85979173
7Abnormality of aromatic amino acid family metabolism (HP:0004338)6.81826246
8Conjugated hyperbilirubinemia (HP:0002908)6.29696647
9Systemic lupus erythematosus (HP:0002725)6.06531727
10Hyperlipoproteinemia (HP:0010980)5.93235623
11Joint hemorrhage (HP:0005261)5.27763134
12Intrahepatic cholestasis (HP:0001406)5.07470757
13Hypolipoproteinemia (HP:0010981)4.69680651
14Glomerulonephritis (HP:0000099)4.69412923
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.39428057
16Xanthomatosis (HP:0000991)4.32160540
17Abnormality of pyrimidine metabolism (HP:0004353)4.25256183
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19633009
19Spontaneous abortion (HP:0005268)3.91311019
20Hyperglycinemia (HP:0002154)3.90543324
21Nephritis (HP:0000123)3.79184311
22Hyperammonemia (HP:0001987)3.77902922
23Abnormality of serine family amino acid metabolism (HP:0010894)3.71659324
24Abnormality of glycine metabolism (HP:0010895)3.71659324
25Fat malabsorption (HP:0002630)3.68783112
26Hypoalphalipoproteinemia (HP:0003233)3.66912264
27Recurrent gram-negative bacterial infections (HP:0005420)3.54404297
28Abnormality of the common coagulation pathway (HP:0010990)3.49699484
29Hyperglycinuria (HP:0003108)3.38244671
30Abnormality of methionine metabolism (HP:0010901)3.24706907
31Abnormality of the intrinsic pathway (HP:0010989)3.13116486
32Generalized aminoaciduria (HP:0002909)3.10982671
33Neonatal hypoglycemia (HP:0001998)3.03387246
34Abnormality of aspartate family amino acid metabolism (HP:0010899)2.92620419
35Abnormality of serum amino acid levels (HP:0003112)2.91482827
36Epidermoid cyst (HP:0200040)2.86629266
37Osteomalacia (HP:0002749)2.86598926
38Delayed CNS myelination (HP:0002188)2.80763098
39Abnormality of nucleobase metabolism (HP:0010932)2.65360705
40Rickets (HP:0002748)2.65234118
41Steatorrhea (HP:0002570)2.64413467
42Abnormality of sulfur amino acid metabolism (HP:0004339)2.63764311
43Hemorrhage of the eye (HP:0011885)2.60135153
44Abnormality of urine glucose concentration (HP:0011016)2.58742494
45Glycosuria (HP:0003076)2.58742494
46Fair hair (HP:0002286)2.51274775
47Vascular calcification (HP:0004934)2.51111284
48Abnormality of vitamin metabolism (HP:0100508)2.48108662
49Metabolic acidosis (HP:0001942)2.47734149
50Congenital sensorineural hearing impairment (HP:0008527)2.44628209
51Ketosis (HP:0001946)2.39958119
52Bifid scrotum (HP:0000048)2.38347078
53Hypercholesterolemia (HP:0003124)2.33263202
54Hyperbilirubinemia (HP:0002904)2.25811617
55Alkalosis (HP:0001948)2.24590672
56Proximal tubulopathy (HP:0000114)2.21387210
57Cerebral palsy (HP:0100021)2.20064666
58Gingival bleeding (HP:0000225)2.14202264
59Cardiovascular calcification (HP:0011915)2.14061321
60Reduced antithrombin III activity (HP:0001976)2.13838337
61Pulmonary embolism (HP:0002204)2.10341163
62Hyperphosphaturia (HP:0003109)2.08951281
63Blue irides (HP:0000635)2.08813480
64Thrombophlebitis (HP:0004418)2.07153272
65Malnutrition (HP:0004395)1.97729479
66Back pain (HP:0003418)1.97683608
67Abnormality of proline metabolism (HP:0010907)1.96331462
68Hydroxyprolinuria (HP:0003080)1.96331462
69Abnormality of purine metabolism (HP:0004352)1.92075278
70Purpura (HP:0000979)1.82677500
71Generalized hypopigmentation of hair (HP:0011358)1.81857997
72Lethargy (HP:0001254)1.81627940
73Arthropathy (HP:0003040)1.80913974
74Stroke (HP:0001297)1.79077790
75Irritability (HP:0000737)1.78774237
76Skin nodule (HP:0200036)1.77303161
77Ketoacidosis (HP:0001993)1.76901835
78Abnormal urine phosphate concentration (HP:0012599)1.75929384
79Hypoglycemic coma (HP:0001325)1.74291396
80Abnormality of fatty-acid metabolism (HP:0004359)1.70731317
81Pancreatitis (HP:0001733)1.69613747
82Elevated alkaline phosphatase (HP:0003155)1.69088781
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.66590480
84Amyloidosis (HP:0011034)1.65266103
85Abnormal enzyme/coenzyme activity (HP:0012379)1.65009841
86Abnormality of alkaline phosphatase activity (HP:0004379)1.60563749
87Abnormality of iron homeostasis (HP:0011031)1.58190152
88Menorrhagia (HP:0000132)1.58166554
89Nephrolithiasis (HP:0000787)1.57984607
90Abnormality of transition element cation homeostasis (HP:0011030)1.57712194
91Hepatocellular carcinoma (HP:0001402)1.57041563
92Acanthocytosis (HP:0001927)1.56382310
93Gout (HP:0001997)1.56187324
94Potter facies (HP:0002009)1.55819763
95Facial shape deformation (HP:0011334)1.55819763
96Abnormal tarsal ossification (HP:0008369)1.55706117
97Poikilocytosis (HP:0004447)1.54604171
98Sensorimotor neuropathy (HP:0007141)1.53903524
99Abnormality of secondary sexual hair (HP:0009888)1.52997150
100Abnormality of the axillary hair (HP:0100134)1.52997150

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.82839402
2PRKD34.32839137
3PNCK3.81416000
4AKT33.46689849
5EPHB13.43460204
6TSSK63.05856304
7ACVR1B2.53379073
8MAPKAPK32.43046108
9NEK92.37521816
10MAPK132.33886388
11CASK2.22521551
12CAMK1D2.08766083
13MAPKAPK52.01015503
14FER1.97203457
15PIK3CA1.94398147
16STK391.92642983
17TNK21.89965779
18CAMK1G1.80192077
19FGFR41.73487251
20GRK11.61150498
21LATS11.55021004
22ERN11.45403593
23TRIB31.39679972
24TAOK31.37225956
25MAP2K21.33865301
26EPHA31.29414196
27NLK1.26344730
28EPHA41.16770510
29RIPK11.15820982
30MAP2K41.14329596
31CAMKK21.10690984
32DDR21.10222659
33DAPK21.09626250
34PRKD21.05592375
35TYRO31.02562615
36PKN20.98355000
37OXSR10.97003370
38PRKACG0.96380050
39PTK60.91909170
40MAP3K120.90595960
41MST1R0.89336966
42PKN10.83075436
43NTRK30.82851947
44SIK10.81030165
45WNK30.80635355
46SGK2230.80268543
47SGK4940.80268543
48ERBB20.78803157
49SGK20.76503664
50MAP3K20.75800739
51MYLK0.73051039
52TAOK10.72775369
53MELK0.72563454
54PRKCG0.71690496
55PRKAA20.66207569
56STK380.65702874
57DYRK1B0.65492434
58RET0.64323052
59CAMKK10.63927457
60PRKCZ0.63831276
61PRKACA0.62034410
62KSR20.60466966
63EPHB20.57218352
64KSR10.57101430
65FGFR30.55896287
66MAP3K10.53152263
67EEF2K0.51834883
68WNK40.49317503
69PRKD10.47188960
70MAP3K90.46941705
71PAK30.46537113
72MAP3K30.45579838
73IGF1R0.45222032
74PRKCA0.44319456
75PDPK10.43328003
76EPHA20.42181801
77WEE10.41835097
78MAPK110.40923317
79PAK20.40781265
80PINK10.40276622
81SGK10.39263091
82TYK20.37217198
83STK38L0.37109329
84MAP3K110.36871951
85LMTK20.35532261
86PRKCH0.35519586
87FRK0.35195181
88MARK20.34194584
89GRK70.32487278
90SGK30.31648717
91CSNK1A10.29321651
92PRKCE0.27668029
93CDC42BPA0.27089192
94PRKCI0.26338268
95MAP2K10.26055444
96BCKDK0.26046678
97MET0.25511076
98RPS6KA30.24958981
99MAPKAPK20.24841680
100SRC0.23463151

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.67428661
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.10351135
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.45599883
4Retinol metabolism_Homo sapiens_hsa008303.40042412
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21386691
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.20114690
7Complement and coagulation cascades_Homo sapiens_hsa046103.13876176
8Chemical carcinogenesis_Homo sapiens_hsa052042.97653087
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.91579740
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.58930711
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.51280768
12Fatty acid degradation_Homo sapiens_hsa000712.47761851
13Arginine biosynthesis_Homo sapiens_hsa002202.46475135
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.37892445
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.37555027
16Phenylalanine metabolism_Homo sapiens_hsa003602.31243593
17Cyanoamino acid metabolism_Homo sapiens_hsa004602.27244022
18Linoleic acid metabolism_Homo sapiens_hsa005912.25098236
19Histidine metabolism_Homo sapiens_hsa003402.21965258
20Tyrosine metabolism_Homo sapiens_hsa003502.18952082
21Butanoate metabolism_Homo sapiens_hsa006502.06807804
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93288377
23Bile secretion_Homo sapiens_hsa049761.92025290
24Tryptophan metabolism_Homo sapiens_hsa003801.82643635
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66250112
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.54560981
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47485685
28Starch and sucrose metabolism_Homo sapiens_hsa005001.46530294
29beta-Alanine metabolism_Homo sapiens_hsa004101.46178338
30Arachidonic acid metabolism_Homo sapiens_hsa005901.45029640
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44658900
32Peroxisome_Homo sapiens_hsa041461.43542024
33PPAR signaling pathway_Homo sapiens_hsa033201.41778467
34Fat digestion and absorption_Homo sapiens_hsa049751.29720380
35Arginine and proline metabolism_Homo sapiens_hsa003301.23860236
36Prion diseases_Homo sapiens_hsa050201.19078140
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.18464897
38Propanoate metabolism_Homo sapiens_hsa006401.13766941
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10501113
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04658839
41Staphylococcus aureus infection_Homo sapiens_hsa051501.03629795
42Vitamin B6 metabolism_Homo sapiens_hsa007500.93171615
43Sulfur metabolism_Homo sapiens_hsa009200.91648638
44Pyruvate metabolism_Homo sapiens_hsa006200.91227811
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88272221
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83832734
47Vitamin digestion and absorption_Homo sapiens_hsa049770.81828748
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77521584
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76707322
50Biosynthesis of amino acids_Homo sapiens_hsa012300.74605133
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.73995279
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72927302
53Fatty acid metabolism_Homo sapiens_hsa012120.70325744
54ABC transporters_Homo sapiens_hsa020100.67675000
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67656400
56Carbon metabolism_Homo sapiens_hsa012000.62136856
57Fructose and mannose metabolism_Homo sapiens_hsa000510.54750464
58Sulfur relay system_Homo sapiens_hsa041220.50749334
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50030471
60Lysine degradation_Homo sapiens_hsa003100.49145170
61One carbon pool by folate_Homo sapiens_hsa006700.48046618
62Renin-angiotensin system_Homo sapiens_hsa046140.47939634
63Mineral absorption_Homo sapiens_hsa049780.45425216
64Glycerolipid metabolism_Homo sapiens_hsa005610.42742168
65Metabolic pathways_Homo sapiens_hsa011000.41739989
66Glutathione metabolism_Homo sapiens_hsa004800.33283297
67Pertussis_Homo sapiens_hsa051330.20401752
68Fatty acid biosynthesis_Homo sapiens_hsa000610.19807384
69Ether lipid metabolism_Homo sapiens_hsa005650.18400036
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16301759
71Selenocompound metabolism_Homo sapiens_hsa004500.14374036
72Insulin resistance_Homo sapiens_hsa049310.13794478
73Nitrogen metabolism_Homo sapiens_hsa009100.13646784
74Glucagon signaling pathway_Homo sapiens_hsa049220.10767267
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09658724
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.09170729
77Serotonergic synapse_Homo sapiens_hsa047260.08428550
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.02437467
79Galactose metabolism_Homo sapiens_hsa000520.00851439
80Insulin signaling pathway_Homo sapiens_hsa04910-0.2260685
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.2017548
82TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1951712
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1575803
84Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1502289
85Pentose phosphate pathway_Homo sapiens_hsa00030-0.1272271
86Pancreatic secretion_Homo sapiens_hsa04972-0.1207147
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.1142688
88African trypanosomiasis_Homo sapiens_hsa05143-0.1108534
89Cocaine addiction_Homo sapiens_hsa05030-0.0992608
90Amoebiasis_Homo sapiens_hsa05146-0.0854081
91Sphingolipid metabolism_Homo sapiens_hsa00600-0.0822026
92Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0788263
93Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0749879
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0642699
95Fatty acid elongation_Homo sapiens_hsa00062-0.0579166
96AMPK signaling pathway_Homo sapiens_hsa04152-0.0333621
97Protein digestion and absorption_Homo sapiens_hsa04974-0.0272441
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0151582
99Steroid biosynthesis_Homo sapiens_hsa00100-0.0142262
100Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0016450

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »