FOLR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of complement activation (GO:0045916)7.30884328
2surfactant homeostasis (GO:0043129)6.76329233
3negative regulation of protein activation cascade (GO:2000258)6.54500862
4negative regulation of humoral immune response (GO:0002921)6.13576887
5purine nucleobase biosynthetic process (GO:0009113)5.93974822
6midgut development (GO:0007494)5.82515577
7urate metabolic process (GO:0046415)5.57613277
8vitamin transmembrane transport (GO:0035461)5.46463595
9diaphragm development (GO:0060539)5.36583887
10nucleobase biosynthetic process (GO:0046112)5.36193097
11ribosome assembly (GO:0042255)5.30550703
12chemical homeostasis within a tissue (GO:0048875)5.11576663
13urea cycle (GO:0000050)5.11125633
14mitotic metaphase plate congression (GO:0007080)4.80061783
15urea metabolic process (GO:0019627)4.53516455
16skeletal muscle organ development (GO:0060538)4.50719725
17positive regulation of vascular permeability (GO:0043117)4.43335498
18COPI coating of Golgi vesicle (GO:0048205)4.41602065
19Golgi transport vesicle coating (GO:0048200)4.41602065
20citrulline metabolic process (GO:0000052)4.33417157
21pantothenate metabolic process (GO:0015939)4.21151532
22rRNA modification (GO:0000154)4.16400153
23nucleobase-containing small molecule interconversion (GO:0015949)4.12256456
24nitrogen cycle metabolic process (GO:0071941)4.12212332
25proteasome assembly (GO:0043248)4.11622207
26ribosome biogenesis (GO:0042254)4.09550244
27serine family amino acid catabolic process (GO:0009071)3.99252980
28biotin metabolic process (GO:0006768)3.95030013
29* modified amino acid transport (GO:0072337)3.93676739
30formation of translation preinitiation complex (GO:0001731)3.89642840
31DNA replication checkpoint (GO:0000076)3.88150454
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.87627480
33termination of RNA polymerase III transcription (GO:0006386)3.87627480
34NADH metabolic process (GO:0006734)3.86859104
35intestinal epithelial cell development (GO:0060576)3.81601837
36response to growth hormone (GO:0060416)3.80331186
37* folic acid metabolic process (GO:0046655)3.79101346
38regulation of spindle organization (GO:0090224)3.78174653
39lung-associated mesenchyme development (GO:0060484)3.75811003
40protein autoprocessing (GO:0016540)3.74302976
41glycine metabolic process (GO:0006544)3.69354796
42regulation of translation in response to stress (GO:0043555)3.58575056
43metaphase plate congression (GO:0051310)3.57137185
44blastocyst development (GO:0001824)3.57008154
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.56963642
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56860389
47serine family amino acid metabolic process (GO:0009069)3.52862984
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51828749
49drug transmembrane transport (GO:0006855)3.50613785
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46516681
51axonemal dynein complex assembly (GO:0070286)3.45044240
52tricarboxylic acid cycle (GO:0006099)3.45023378
53drug transport (GO:0015893)3.43995004
54response to dexamethasone (GO:0071548)3.43836560
55regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41955938
56transcription from RNA polymerase I promoter (GO:0006360)3.41928700
57* vitamin transport (GO:0051180)3.39709467
58termination of RNA polymerase I transcription (GO:0006363)3.39367888
59regulation of complement activation (GO:0030449)3.38058928
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35850612
617-methylguanosine mRNA capping (GO:0006370)3.34317707
62transcription elongation from RNA polymerase I promoter (GO:0006362)3.30975600
63DNA deamination (GO:0045006)3.28387008
64maturation of SSU-rRNA (GO:0030490)3.27519980
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26746052
66negative regulation of vascular permeability (GO:0043116)3.24784329
67tricarboxylic acid metabolic process (GO:0072350)3.24104360
68cGMP-mediated signaling (GO:0019934)3.21171553
69ribonucleoprotein complex biogenesis (GO:0022613)3.20432109
70RNA capping (GO:0036260)3.20231977
717-methylguanosine RNA capping (GO:0009452)3.20231977
72amino acid salvage (GO:0043102)3.19620099
73L-methionine salvage (GO:0071267)3.19620099
74L-methionine biosynthetic process (GO:0071265)3.19620099
75oxidative phosphorylation (GO:0006119)3.18209134
76serine family amino acid biosynthetic process (GO:0009070)3.16418486
77phosphate ion transport (GO:0006817)3.15997670
78viral transcription (GO:0019083)3.15823021
79telomere maintenance via semi-conservative replication (GO:0032201)3.15730233
80notochord development (GO:0030903)3.14802435
81cellular response to nitric oxide (GO:0071732)3.14656651
82aminoglycoside antibiotic metabolic process (GO:0030647)3.14363305
83ribosomal small subunit biogenesis (GO:0042274)3.13816640
84regulation of G0 to G1 transition (GO:0070316)3.12140392
85interferon-gamma secretion (GO:0072643)3.11276065
86homocysteine metabolic process (GO:0050667)3.11194937
87regulation of protein activation cascade (GO:2000257)3.10669976
88mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.10626667
89translational termination (GO:0006415)3.10148894
90positive regulation of chromosome segregation (GO:0051984)3.09827877
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09558583
92sulfur amino acid biosynthetic process (GO:0000097)3.09345470
93bundle of His cell to Purkinje myocyte communication (GO:0086069)3.09034426
94glutamine family amino acid biosynthetic process (GO:0009084)3.05163842
95fructose metabolic process (GO:0006000)3.04291110
96cotranslational protein targeting to membrane (GO:0006613)3.03913902
97positive regulation of ligase activity (GO:0051351)3.03727352
98prostaglandin biosynthetic process (GO:0001516)3.02683682
99prostanoid biosynthetic process (GO:0046457)3.02683682
100protein targeting to ER (GO:0045047)3.02527119
101ribosomal small subunit assembly (GO:0000028)3.02050822
102transcription initiation from RNA polymerase I promoter (GO:0006361)3.01779149
103establishment of protein localization to mitochondrial membrane (GO:0090151)3.00234116
104rRNA methylation (GO:0031167)2.99527543
105negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.99083459
106negative regulation of ligase activity (GO:0051352)2.99083459
107regulation of mitochondrial translation (GO:0070129)2.99040293
108protein localization to kinetochore (GO:0034501)2.98806408
109regulation of cellular amino acid metabolic process (GO:0006521)2.98684651
110pentose-phosphate shunt (GO:0006098)2.98627153
111pyrimidine-containing compound transmembrane transport (GO:0072531)2.98365289
112CDP-diacylglycerol metabolic process (GO:0046341)2.98272248
113rRNA processing (GO:0006364)2.97463745
114labyrinthine layer development (GO:0060711)2.95612836
115desmosome organization (GO:0002934)2.95110761
116establishment of apical/basal cell polarity (GO:0035089)2.94719845
117DNA strand elongation involved in DNA replication (GO:0006271)2.94401860
118galactose metabolic process (GO:0006012)2.94184424
119guanosine-containing compound biosynthetic process (GO:1901070)2.93955193
120regulation of mitotic spindle organization (GO:0060236)2.92625747
121amino sugar catabolic process (GO:0046348)2.92508874
122protein localization to endoplasmic reticulum (GO:0070972)2.91250244
123spliceosomal snRNP assembly (GO:0000387)2.91247332
124establishment of protein localization to endoplasmic reticulum (GO:0072599)2.88884015
125negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.88856165
126rRNA metabolic process (GO:0016072)2.88124548
127phosphate ion transmembrane transport (GO:0035435)2.88037968
128NADPH regeneration (GO:0006740)2.87040207
129spindle checkpoint (GO:0031577)2.86404374
130methionine biosynthetic process (GO:0009086)2.85559955
131regulation of ubiquitin-protein transferase activity (GO:0051438)2.83936420
132autophagic vacuole assembly (GO:0000045)2.82849844
133DNA strand elongation (GO:0022616)2.82151567
134negative regulation of translational initiation (GO:0045947)2.82014709
135DNA replication initiation (GO:0006270)2.81712709
136chaperone-mediated protein complex assembly (GO:0051131)2.80512229
137galactose catabolic process (GO:0019388)2.79213323
138ribosomal large subunit biogenesis (GO:0042273)2.78618542
139regulation of integrin-mediated signaling pathway (GO:2001044)2.78084367
140establishment of chromosome localization (GO:0051303)2.77536818
141mitotic spindle checkpoint (GO:0071174)2.76183644
142cysteine metabolic process (GO:0006534)2.75779302
143methionine metabolic process (GO:0006555)2.74935350
144GMP metabolic process (GO:0046037)2.74765635
145histone-serine phosphorylation (GO:0035404)2.74460963
146N-acetylneuraminate metabolic process (GO:0006054)2.73736522
147mitotic nuclear envelope disassembly (GO:0007077)2.73628057
148regulation of chromosome segregation (GO:0051983)2.71366658
149transcription elongation from RNA polymerase II promoter (GO:0006368)2.69926233
150translational elongation (GO:0006414)2.69588205
151negative regulation of chromosome segregation (GO:0051985)2.68161267
152organic cation transport (GO:0015695)2.67716424
153DNA-templated transcription, elongation (GO:0006354)2.66728262
154regulation of ligase activity (GO:0051340)2.66411563
155signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66316137
156signal transduction involved in DNA damage checkpoint (GO:0072422)2.66316137
157positive regulation of viral transcription (GO:0050434)2.66117348
158protein maturation by protein folding (GO:0022417)2.65631760
159lysine metabolic process (GO:0006553)2.65514585
160viral life cycle (GO:0019058)2.65452615
161regulation of apoptotic process involved in morphogenesis (GO:1902337)2.64764034
162nuclear pore complex assembly (GO:0051292)2.63482006
163negative regulation of response to reactive oxygen species (GO:1901032)2.62337179
164translational initiation (GO:0006413)2.62207723
165cellular response to antibiotic (GO:0071236)2.60612074
166motile cilium assembly (GO:0044458)2.54716090
167respiratory electron transport chain (GO:0022904)2.54119920
168positive regulation of hair cycle (GO:0042635)2.53312471
169positive regulation of hair follicle development (GO:0051798)2.53312471
170telomere maintenance via recombination (GO:0000722)2.50992541
171nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.50316216
172cellular response to dexamethasone stimulus (GO:0071549)2.48974613
173renal absorption (GO:0070293)2.48914986
174electron transport chain (GO:0022900)2.48477201
175signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.47187543
176intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.47187543
177signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.45384543
178signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.45384543
179signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.45384543
180regulation of hydrogen peroxide-induced cell death (GO:1903205)2.45213362
181DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.45069011
182cellular protein complex disassembly (GO:0043624)2.44536593
183cilium movement (GO:0003341)2.43948834
184positive regulation of p38MAPK cascade (GO:1900745)2.43672172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.89928250
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.45839918
3E2F7_22180533_ChIP-Seq_HELA_Human3.96810122
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.66075062
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49818418
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.34168287
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.33824848
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.21578634
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.21497732
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.95120218
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93388296
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92066619
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.91351704
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.89566562
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.76813321
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68288128
17AR_21909140_ChIP-Seq_LNCAP_Human2.63379318
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63081023
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59168208
20NANOG_18555785_ChIP-Seq_MESCs_Mouse2.39345849
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.38868837
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.33957516
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32254790
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.29919857
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.23153623
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18896565
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18428456
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17163111
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16582730
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13072018
31CLOCK_20551151_ChIP-Seq_293T_Human2.10481630
32VDR_23849224_ChIP-Seq_CD4+_Human2.08820631
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07407987
34ZNF263_19887448_ChIP-Seq_K562_Human2.01502137
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96414435
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95638544
37XRN2_22483619_ChIP-Seq_HELA_Human1.94120819
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.92082708
39GABP_19822575_ChIP-Seq_HepG2_Human1.87070442
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86812891
41HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.85493019
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84956673
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83936978
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.83648685
45DCP1A_22483619_ChIP-Seq_HELA_Human1.75293996
46NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72353038
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70331538
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69063991
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68155528
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63224868
51KDM5A_27292631_Chip-Seq_BREAST_Human1.58691198
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57682797
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57189997
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57015086
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55658503
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54329203
57* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.51177271
58FOXP3_21729870_ChIP-Seq_TREG_Human1.50053682
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48118255
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47739060
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46162046
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44667920
63ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.44119643
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43651179
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43353475
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42070140
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41109233
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39361533
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36914042
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36914042
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.36123298
72NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35436766
73TTF2_22483619_ChIP-Seq_HELA_Human1.34734603
74* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33474425
75RACK7_27058665_Chip-Seq_MCF-7_Human1.33161500
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32735806
77SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32081446
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31873879
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30616426
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30260839
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27356106
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26963910
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26963910
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26963910
85SMC4_20622854_ChIP-Seq_HELA_Human1.26222075
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25028564
87* NANOG_21062744_ChIP-ChIP_HESCs_Human1.23459183
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.22576537
89NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22404851
90GATA6_25053715_ChIP-Seq_YYC3_Human1.21664504
91* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21409546
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21013616
93GATA3_24758297_ChIP-Seq_MCF-7_Human1.19800964
94* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17363373
95ATF3_27146783_Chip-Seq_COLON_Human1.17299904
96ELK1_22589737_ChIP-Seq_MCF10A_Human1.16992235
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.15664695
98* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14936380
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.14306271
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13131266
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12937990
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12770254
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11667251
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10898821
105GATA4_25053715_ChIP-Seq_YYC3_Human1.10344251
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10122620
107KAP1_27257070_Chip-Seq_ESCs_Mouse1.08069340
108TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.07520351
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07176521
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07062710
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06914721
112* SOX2_20726797_ChIP-Seq_SW620_Human1.06890575
113CIITA_25753668_ChIP-Seq_RAJI_Human1.06810344
114* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06097455
115POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05707908
116* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04116180
117KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03652039
118ELK1_19687146_ChIP-ChIP_HELA_Human1.03568456
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02736674
120ELF5_23300383_ChIP-Seq_T47D_Human1.02629033
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02393131
122SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01954680
123TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01819713
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01649459
125SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00782278
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98630588
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97885867
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97264007
129* SOX17_20123909_ChIP-Seq_XEN_Mouse0.97260965
130* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97189510
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96917800
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96123851
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96021306
134TFEB_21752829_ChIP-Seq_HELA_Human0.95449101
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94684606
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94678109
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94232930
138* EOMES_21245162_ChIP-Seq_HESCs_Human0.93288413
139NANOG_18692474_ChIP-Seq_MESCs_Mouse0.92161181
140CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91260851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.32644180
2MP0004782_abnormal_surfactant_physiolog4.20325896
3MP0000537_abnormal_urethra_morphology3.95565781
4MP0003718_maternal_effect3.91874035
5MP0003111_abnormal_nucleus_morphology3.72182312
6MP0004957_abnormal_blastocyst_morpholog3.53177240
7MP0005623_abnormal_meninges_morphology3.45910435
8* MP0004019_abnormal_vitamin_homeostasis3.36122914
9MP0003878_abnormal_ear_physiology3.19316461
10MP0005377_hearing/vestibular/ear_phenot3.19316461
11MP0004043_abnormal_pH_regulation3.13202488
12MP0002877_abnormal_melanocyte_morpholog3.04870222
13MP0008004_abnormal_stomach_pH2.76560795
14* MP0005332_abnormal_amino_acid2.71965939
15MP0005083_abnormal_biliary_tract2.68170382
16MP0001756_abnormal_urination2.66658289
17MP0005360_urolithiasis2.64425726
18MP0003077_abnormal_cell_cycle2.60412479
19MP0010386_abnormal_urinary_bladder2.56713961
20MP0008260_abnormal_autophagy2.50855006
21MP0001881_abnormal_mammary_gland2.44795754
22MP0010094_abnormal_chromosome_stability2.36611102
23MP0009643_abnormal_urine_homeostasis2.34570920
24MP0003786_premature_aging2.28549450
25MP0009840_abnormal_foam_cell2.23095902
26MP0005395_other_phenotype2.12566631
27MP0010030_abnormal_orbit_morphology2.11892718
28MP0000579_abnormal_nail_morphology2.09779699
29MP0003195_calcinosis2.09504973
30MP0008995_early_reproductive_senescence2.07232732
31MP0001853_heart_inflammation2.04361475
32MP0001661_extended_life_span2.00919491
33MP0001730_embryonic_growth_arrest1.97398879
34MP0003566_abnormal_cell_adhesion1.96194436
35MP0003123_paternal_imprinting1.95747502
36MP0004264_abnormal_extraembryonic_tissu1.81514182
37MP0008058_abnormal_DNA_repair1.80601854
38MP0003186_abnormal_redox_activity1.79807942
39MP0005058_abnormal_lysosome_morphology1.78426126
40MP0005451_abnormal_body_composition1.73545997
41MP0005636_abnormal_mineral_homeostasis1.72465371
42MP0001765_abnormal_ion_homeostasis1.69237404
43MP0002136_abnormal_kidney_physiology1.65688690
44* MP0008932_abnormal_embryonic_tissue1.63771666
45MP0000013_abnormal_adipose_tissue1.62441706
46MP0004233_abnormal_muscle_weight1.61307048
47MP0008057_abnormal_DNA_replication1.58942175
48MP0001346_abnormal_lacrimal_gland1.57018589
49* MP0001672_abnormal_embryogenesis/_devel1.53875886
50* MP0005380_embryogenesis_phenotype1.53875886
51MP0002132_abnormal_respiratory_system1.50341903
52MP0003315_abnormal_perineum_morphology1.49776576
53MP0008875_abnormal_xenobiotic_pharmacok1.49213355
54MP0010678_abnormal_skin_adnexa1.48012155
55MP0003950_abnormal_plasma_membrane1.47071518
56MP0000003_abnormal_adipose_tissue1.45446658
57MP0004272_abnormal_basement_membrane1.43900155
58MP0001697_abnormal_embryo_size1.43094775
59MP0003806_abnormal_nucleotide_metabolis1.36354424
60MP0005670_abnormal_white_adipose1.36036510
61* MP0003984_embryonic_growth_retardation1.35893768
62MP0003136_yellow_coat_color1.33965081
63* MP0002088_abnormal_embryonic_growth/wei1.33594004
64MP0000350_abnormal_cell_proliferation1.32716738
65MP0000383_abnormal_hair_follicle1.32453011
66MP0008007_abnormal_cellular_replicative1.31935197
67MP0001764_abnormal_homeostasis1.31382084
68MP0000627_abnormal_mammary_gland1.27258704
69MP0002295_abnormal_pulmonary_circulatio1.26087912
70* MP0002080_prenatal_lethality1.24218665
71MP0002653_abnormal_ependyma_morphology1.21329182
72MP0003941_abnormal_skin_development1.19710758
73MP0006036_abnormal_mitochondrial_physio1.18659917
74MP0000647_abnormal_sebaceous_gland1.17083830
75MP0002086_abnormal_extraembryonic_tissu1.12095549
76MP0002139_abnormal_hepatobiliary_system1.11717402
77MP0005023_abnormal_wound_healing1.11704546
78* MP0002085_abnormal_embryonic_tissue1.10220057
79MP0001145_abnormal_male_reproductive1.07736789
80MP0003453_abnormal_keratinocyte_physiol1.05356958
81MP0001542_abnormal_bone_strength1.05061753
82MP0000762_abnormal_tongue_morphology1.04239425
83* MP0002084_abnormal_developmental_patter1.04152690
84MP0001216_abnormal_epidermal_layer1.04040104
85MP0000358_abnormal_cell_content/1.03455664
86MP0000750_abnormal_muscle_regeneration1.03366637
87MP0001958_emphysema1.03148632
88MP0001348_abnormal_lacrimal_gland1.00936959
89MP0008438_abnormal_cutaneous_collagen1.00824170
90MP0005666_abnormal_adipose_tissue1.00458809
91MP0010771_integument_phenotype1.00210720
92MP0006035_abnormal_mitochondrial_morpho0.99833058
93MP0003567_abnormal_fetal_cardiomyocyte0.99271295
94MP0005410_abnormal_fertilization0.98831963
95MP0001243_abnormal_dermal_layer0.97548751
96MP0005584_abnormal_enzyme/coenzyme_acti0.96720474
97MP0004885_abnormal_endolymph0.96585224
98MP0003221_abnormal_cardiomyocyte_apopto0.96371695
99MP0002796_impaired_skin_barrier0.96205851
100MP0005165_increased_susceptibility_to0.95695028
101MP0001293_anophthalmia0.95150499
102MP0000733_abnormal_muscle_development0.92206497
103MP0009672_abnormal_birth_weight0.92009687
104MP0002697_abnormal_eye_size0.90512904
105MP0004185_abnormal_adipocyte_glucose0.89834452
106MP0003011_delayed_dark_adaptation0.89272102
107MP0002168_other_aberrant_phenotype0.89036027
108MP0002060_abnormal_skin_morphology0.88513261
109MP0010234_abnormal_vibrissa_follicle0.87673457
110MP0002210_abnormal_sex_determination0.87169787
111MP0003656_abnormal_erythrocyte_physiolo0.86753022
112MP0005319_abnormal_enzyme/_coenzyme0.86090658
113MP0010307_abnormal_tumor_latency0.85447941
114MP0001727_abnormal_embryo_implantation0.85217565
115MP0003936_abnormal_reproductive_system0.84934020
116MP0005389_reproductive_system_phenotype0.84610075
117MP0001929_abnormal_gametogenesis0.84283151
118MP0002396_abnormal_hematopoietic_system0.84017637
119MP0000653_abnormal_sex_gland0.82490596
120MP0005501_abnormal_skin_physiology0.80978788
121MP0000313_abnormal_cell_death0.80441273
122MP0005330_cardiomyopathy0.79689435
123MP0000747_muscle_weakness0.77645046
124MP0010352_gastrointestinal_tract_polyps0.76663746
125MP0009333_abnormal_splenocyte_physiolog0.75315972
126MP0000566_synostosis0.74566791
127MP0003638_abnormal_response/metabolism_0.72859956
128MP0004084_abnormal_cardiac_muscle0.72558252
129MP0002098_abnormal_vibrissa_morphology0.72141488
130MP0005275_abnormal_skin_tensile0.71766607
131MP0000377_abnormal_hair_follicle0.71162391
132MP0003119_abnormal_digestive_system0.71003297
133MP0005384_cellular_phenotype0.70671287
134MP0002160_abnormal_reproductive_system0.70057061
135MP0001919_abnormal_reproductive_system0.69190850
136MP0003705_abnormal_hypodermis_morpholog0.68133225
137MP0002138_abnormal_hepatobiliary_system0.67792991
138* MP0000490_abnormal_crypts_of0.66941116
139MP0005621_abnormal_cell_physiology0.66780755
140MP0008877_abnormal_DNA_methylation0.66494085
141MP0005085_abnormal_gallbladder_physiolo0.66251763
142MP0002896_abnormal_bone_mineralization0.65836374
143MP0009703_decreased_birth_body0.64818163
144MP0003879_abnormal_hair_cell0.64198456
145MP0003646_muscle_fatigue0.64095759
146MP0002092_abnormal_eye_morphology0.63819418
147MP0005197_abnormal_uvea_morphology0.61860783
148MP0003283_abnormal_digestive_organ0.61204075
149MP0005076_abnormal_cell_differentiation0.60400047

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)6.88350314
2Hyperglycinuria (HP:0003108)5.99038590
3Hyperglycinemia (HP:0002154)5.30544603
4Interstitial pulmonary disease (HP:0006530)4.78919362
5Abnormality of glycine metabolism (HP:0010895)4.78346650
6Abnormality of serine family amino acid metabolism (HP:0010894)4.78346650
7Carpal bone hypoplasia (HP:0001498)4.41082440
8Increased purine levels (HP:0004368)4.40102287
9Hyperuricemia (HP:0002149)4.40102287
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.37717543
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.30389854
12Abnormality of pyrimidine metabolism (HP:0004353)4.26688643
13Hypokalemic alkalosis (HP:0001949)4.19673202
14Increased circulating renin level (HP:0000848)4.16268913
15Proximal tubulopathy (HP:0000114)4.07422251
16Hypomagnesemia (HP:0002917)3.93961003
17Polyuria (HP:0000103)3.92241519
18Metabolic alkalosis (HP:0200114)3.89448906
19Breast hypoplasia (HP:0003187)3.89037799
20Abnormality of renal excretion (HP:0011036)3.88479540
21Birth length less than 3rd percentile (HP:0003561)3.83275446
22Renal salt wasting (HP:0000127)3.76545796
23Hyperactive renin-angiotensin system (HP:0000841)3.76474537
24Rough bone trabeculation (HP:0100670)3.76058594
25Cerebral edema (HP:0002181)3.66142319
26Abnormal urine output (HP:0012590)3.65064610
27Abnormality of purine metabolism (HP:0004352)3.61453045
28Abnormal respiratory motile cilium physiology (HP:0012261)3.61067475
29Cerebral hypomyelination (HP:0006808)3.57715197
30Abnormality of chloride homeostasis (HP:0011422)3.49204574
31Rhinitis (HP:0012384)3.49024944
32Abnormality of magnesium homeostasis (HP:0004921)3.44066065
33Impulsivity (HP:0100710)3.43650441
34Chronic bronchitis (HP:0004469)3.29784890
35Abnormal ciliary motility (HP:0012262)3.17559804
36Abnormal trabecular bone morphology (HP:0100671)3.12469806
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.01708054
38Multiple enchondromatosis (HP:0005701)2.99533442
39Abnormality of serum amino acid levels (HP:0003112)2.98280670
40Megaloblastic anemia (HP:0001889)2.97630164
41Hypokinesia (HP:0002375)2.87255498
42Delayed epiphyseal ossification (HP:0002663)2.78920960
43Abnormality of nucleobase metabolism (HP:0010932)2.78525598
44Abnormal respiratory epithelium morphology (HP:0012253)2.78218206
45Abnormal respiratory motile cilium morphology (HP:0005938)2.78218206
46Calcaneovalgus deformity (HP:0001848)2.78109483
47Oligodactyly (hands) (HP:0001180)2.76482289
48Short nail (HP:0001799)2.75211677
49Tetany (HP:0001281)2.74091564
50Right ventricular cardiomyopathy (HP:0011663)2.73846249
51Sparse lateral eyebrow (HP:0005338)2.73331189
52Abnormality of the distal phalanges of the toes (HP:0010182)2.71972397
53Cutaneous melanoma (HP:0012056)2.68844868
54Progressive muscle weakness (HP:0003323)2.65394460
55Abnormality of glycolysis (HP:0004366)2.64695527
56Squamous cell carcinoma (HP:0002860)2.64021925
57Hyperammonemia (HP:0001987)2.62315482
58Hyperaldosteronism (HP:0000859)2.54781056
59Abnormal mitochondria in muscle tissue (HP:0008316)2.54447471
60Renal tubular acidosis (HP:0001947)2.53890056
61Death in infancy (HP:0001522)2.53884848
62Stenosis of the external auditory canal (HP:0000402)2.53110190
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.51786782
64Osteolytic defects of the hand bones (HP:0009699)2.51786782
65Alkalosis (HP:0001948)2.51015823
66Secondary amenorrhea (HP:0000869)2.50517369
67Spinal muscular atrophy (HP:0007269)2.50355515
68Tachypnea (HP:0002789)2.50067576
69Ureteral duplication (HP:0000073)2.49705331
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.47852232
71Absent/shortened dynein arms (HP:0200106)2.47852232
72Aplasia/Hypoplasia involving the musculature (HP:0001460)2.47302778
73Lethargy (HP:0001254)2.44465989
74Premature ovarian failure (HP:0008209)2.43698671
75Generalized aminoaciduria (HP:0002909)2.43423977
76Increased serum pyruvate (HP:0003542)2.42155571
77Abnormal drinking behavior (HP:0030082)2.41598804
78Polydipsia (HP:0001959)2.41598804
79Glycosuria (HP:0003076)2.39461273
80Abnormality of urine glucose concentration (HP:0011016)2.39461273
81Abnormality of the umbilical cord (HP:0010881)2.37665059
82Aplasia/Hypoplasia of the patella (HP:0006498)2.33450180
83Deformed tarsal bones (HP:0008119)2.32938284
84Nausea (HP:0002018)2.32731671
85Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32229200
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32229200
87Patellar aplasia (HP:0006443)2.30119802
88CNS hypomyelination (HP:0003429)2.28578177
89Tubulointerstitial nephritis (HP:0001970)2.26951941
90Abnormality of renin-angiotensin system (HP:0000847)2.26652210
91Ventricular fibrillation (HP:0001663)2.25550940
92Bell-shaped thorax (HP:0001591)2.23598296
93Dicarboxylic aciduria (HP:0003215)2.22207287
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22207287
95Muscle fiber splitting (HP:0003555)2.20212278
96Vertebral compression fractures (HP:0002953)2.19420514
97Abnormality of cells of the erythroid lineage (HP:0012130)2.14907274
98Oligodactyly (HP:0012165)2.13661174
99Neoplasm of head and neck (HP:0012288)2.12969755
100Esophageal neoplasm (HP:0100751)2.12969755
101Abnormality of liposaccharide metabolism (HP:0010968)2.12096204
102Abnormality of glycosphingolipid metabolism (HP:0004343)2.12096204
103Abnormality of glycolipid metabolism (HP:0010969)2.12096204
104Abnormality of fatty-acid metabolism (HP:0004359)2.09291893
105Irritability (HP:0000737)2.08526423
106Elbow flexion contracture (HP:0002987)2.08504460
107Respiratory distress (HP:0002098)2.08311616
108Degeneration of anterior horn cells (HP:0002398)2.08269154
109Abnormality of the anterior horn cell (HP:0006802)2.08269154
110Prolonged neonatal jaundice (HP:0006579)2.07264141
111Methylmalonic aciduria (HP:0012120)2.06988310
112Tubulointerstitial fibrosis (HP:0005576)2.06052239
113Microvesicular hepatic steatosis (HP:0001414)2.05619892
114Glucose intolerance (HP:0000833)2.05297861
115Abnormality of dentin (HP:0010299)2.03879431
116Premature rupture of membranes (HP:0001788)2.02903746
117Increased CSF lactate (HP:0002490)1.99201856
118Sparse eyelashes (HP:0000653)1.99149345
119Vascular calcification (HP:0004934)1.99097875
120Confusion (HP:0001289)1.98904246
121Ankyloglossia (HP:0010296)1.98650474
122Submucous cleft hard palate (HP:0000176)1.96941609
123Malnutrition (HP:0004395)1.96779464
124Hypokalemia (HP:0002900)1.96698216
125Aplasia/hypoplasia of the humerus (HP:0006507)1.95748981
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95578963
127Abnormality of alanine metabolism (HP:0010916)1.95578963
128Hyperalaninemia (HP:0003348)1.95578963
129Abnormality of renal resorption (HP:0011038)1.94995131
130Bicornuate uterus (HP:0000813)1.94461706
131Entropion (HP:0000621)1.94211530
132CNS demyelination (HP:0007305)1.94196490
133Metaphyseal cupping (HP:0003021)1.93742542
134Macrocytic anemia (HP:0001972)1.93737705
135Mitral stenosis (HP:0001718)1.93646045
136Microretrognathia (HP:0000308)1.93414431
137Tubular atrophy (HP:0000092)1.93329112
138Nephrocalcinosis (HP:0000121)1.93167204
139Segmental peripheral demyelination/remyelination (HP:0003481)1.92572902
140Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91933049
141Hypercalciuria (HP:0002150)1.91117984
142Bronchiectasis (HP:0002110)1.89985288
143Absent radius (HP:0003974)1.88662370
144Acute necrotizing encephalopathy (HP:0006965)1.88541538
145Aplasia/hypoplasia of the uterus (HP:0008684)1.88371955
146Abnormalities of placenta or umbilical cord (HP:0001194)1.88369615
147Hepatocellular necrosis (HP:0001404)1.86402051
148Abnormality of the calcaneus (HP:0008364)1.86384195
149Respiratory failure (HP:0002878)1.85138896
150Personality changes (HP:0000751)1.84236235
151Renal tubular dysfunction (HP:0000124)1.82148712
152Stillbirth (HP:0003826)1.81018551
153Congenital ichthyosiform erythroderma (HP:0007431)1.80881193
154Nephrolithiasis (HP:0000787)1.79730770
155Trismus (HP:0000211)1.79498288
156Abnormal pancreas size (HP:0012094)1.79465613
157Cardiovascular calcification (HP:0011915)1.79133918
158Abnormality of oral frenula (HP:0000190)1.79127127
159Hepatic necrosis (HP:0002605)1.78887438
160Hypoplasia of the uterus (HP:0000013)1.78241367
161Hyponatremia (HP:0002902)1.77664902
162Vacuolated lymphocytes (HP:0001922)1.76332528
163Oral leukoplakia (HP:0002745)1.76041212
164Ulnar deviation of the wrist (HP:0003049)1.75438378
165Ulnar bowing (HP:0003031)1.75354189
166Reticulocytopenia (HP:0001896)1.75227960
167Postnatal microcephaly (HP:0005484)1.73335666
168Glomerulosclerosis (HP:0000096)1.72981725
169Absent forearm bone (HP:0003953)1.72686217
170Aplasia involving forearm bones (HP:0009822)1.72686217
171Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71329723
172Vertebral hypoplasia (HP:0008417)1.71329723
173Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70739460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.86748790
2PBK4.65717615
3WEE14.30957509
4MST1R3.90313355
5EPHA23.80606593
6WNK33.64757661
7WNK42.90475563
8PLK42.80372039
9TSSK62.68469557
10AKT32.59658955
11PDK32.47558434
12PDK42.47558434
13NEK12.45154801
14EIF2AK12.37232765
15NME22.35502694
16STK38L2.33752961
17TTK2.28957592
18OXSR12.25248454
19PNCK2.17623632
20NEK22.15150405
21MAP3K122.05304108
22PDK22.00274041
23IRAK31.99301747
24BRSK21.98854811
25STK161.87871771
26SRPK11.83029883
27DYRK31.69654077
28BCKDK1.65174483
29PLK11.64543285
30EIF2AK31.62138871
31ZAK1.52489515
32PLK31.49342856
33PINK11.37741319
34TESK11.37313596
35STK391.30861549
36NEK61.29552128
37MAPKAPK51.25938832
38PRKCI1.21951798
39BRSK11.19100842
40MUSK1.14882062
41CHEK21.12167597
42ACVR1B1.12143815
43AURKA1.08286795
44AURKB1.08002427
45TESK21.03508226
46VRK20.99185581
47ILK0.98541623
48MAPK150.97561238
49MYLK0.96380910
50ARAF0.90953102
51STK380.89868200
52BRAF0.89117213
53LATS20.88403136
54STK30.87589617
55RPS6KB20.85997369
56PAK40.84228922
57CDK60.81646151
58MAP3K80.79248251
59NME10.77782865
60CDK80.75397295
61CDK70.74957981
62CCNB10.74313774
63LIMK10.72996890
64MKNK20.70572882
65SCYL20.68349094
66ERBB40.68217548
67CDK40.67642045
68CDC70.66663445
69MAP3K20.63753258
70FER0.63038007
71CHEK10.62316422
72MAP3K30.61923274
73PAK10.60848445
74RPS6KA40.59601613
75CDK120.59157885
76EEF2K0.55140309
77PIM10.55120775
78PRKAA10.54500929
79BMPR20.53253514
80MST40.53113298
81PTK20.51205486
82ALK0.50075487
83ABL20.49937016
84PIM20.49797877
85CSNK1E0.46931092
86VRK10.45888153
87CSNK2A20.44928123
88PRKG20.44914312
89CDK20.44882905
90CAMK2G0.44335720
91DAPK10.43991872
92ATR0.43901653
93MELK0.43669702
94DYRK20.43611433
95MTOR0.41180001
96EIF2AK20.40976955
97CSNK2A10.38298418
98PDPK10.37913285
99MKNK10.37822989
100LATS10.37790553
101TTN0.37733917
102STK100.36460533
103MAP2K20.34510146
104LRRK20.34338761
105MAP2K10.34321323
106AKT20.34244084
107CSNK1A10.33156896
108MAPKAPK30.30817727
109GSK3A0.30341538
110ERBB30.30311726
111CSNK1G10.29761293
112MARK30.28486179
113CDK10.28050225
114CAMK1D0.27349044
115DAPK30.27106098
116BMX0.24652695
117GRK10.22960959
118MET0.21814102
119ZAP700.19588332
120PRKCG0.18621220
121CAMK2B0.17587133
122CSNK1G30.16305881
123RPS6KA50.16104279
124KDR0.15824426
125ATM0.15317358
126MARK10.15279687
127TRIB30.14834410
128IRAK20.14462956
129PRKCD0.14296879
130STK40.14286376
131SGK2230.11473244
132SGK4940.11473244
133STK240.11350674
134TLK10.10966607

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.55273604
2RNA polymerase_Homo sapiens_hsa030203.72031236
3Proteasome_Homo sapiens_hsa030503.39336752
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37073289
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71496427
6Folate biosynthesis_Homo sapiens_hsa007902.56753542
7RNA transport_Homo sapiens_hsa030132.52236509
8Vitamin digestion and absorption_Homo sapiens_hsa049772.41228857
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.29598287
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27081892
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20595877
12Regulation of autophagy_Homo sapiens_hsa041402.19729662
13Pyrimidine metabolism_Homo sapiens_hsa002402.09863539
14DNA replication_Homo sapiens_hsa030301.92147355
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.83738458
16Spliceosome_Homo sapiens_hsa030401.73048574
17Phenylalanine metabolism_Homo sapiens_hsa003601.71664933
18Butanoate metabolism_Homo sapiens_hsa006501.67517513
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.67063693
20Pentose phosphate pathway_Homo sapiens_hsa000301.66534001
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64551880
22Ribosome_Homo sapiens_hsa030101.64176028
23Cell cycle_Homo sapiens_hsa041101.58186897
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56017904
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.54297603
26Mismatch repair_Homo sapiens_hsa034301.52126466
27Fructose and mannose metabolism_Homo sapiens_hsa000511.51832776
28Propanoate metabolism_Homo sapiens_hsa006401.49772439
29Carbon metabolism_Homo sapiens_hsa012001.46516260
30Biosynthesis of amino acids_Homo sapiens_hsa012301.43955361
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.40156652
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.40010268
33Glutathione metabolism_Homo sapiens_hsa004801.39626111
34Alzheimers disease_Homo sapiens_hsa050101.38159442
35Nucleotide excision repair_Homo sapiens_hsa034201.37198597
36Basal transcription factors_Homo sapiens_hsa030221.31677384
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28388283
38Purine metabolism_Homo sapiens_hsa002301.25806792
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25031712
40Homologous recombination_Homo sapiens_hsa034401.20752157
41Base excision repair_Homo sapiens_hsa034101.20685271
42Galactose metabolism_Homo sapiens_hsa000521.19265656
43Vibrio cholerae infection_Homo sapiens_hsa051101.15302630
44Nitrogen metabolism_Homo sapiens_hsa009101.15122189
45Complement and coagulation cascades_Homo sapiens_hsa046101.13760130
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.11935930
47Collecting duct acid secretion_Homo sapiens_hsa049661.09771437
48p53 signaling pathway_Homo sapiens_hsa041151.07459638
49Pyruvate metabolism_Homo sapiens_hsa006201.06672113
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06061075
51Selenocompound metabolism_Homo sapiens_hsa004501.05558975
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04565691
53Arginine and proline metabolism_Homo sapiens_hsa003301.03683417
54Sulfur metabolism_Homo sapiens_hsa009201.01221661
55One carbon pool by folate_Homo sapiens_hsa006701.01105212
56Fatty acid biosynthesis_Homo sapiens_hsa000611.01084266
57Mineral absorption_Homo sapiens_hsa049780.98448881
58Caffeine metabolism_Homo sapiens_hsa002320.98022518
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97189100
60N-Glycan biosynthesis_Homo sapiens_hsa005100.95095765
61Peroxisome_Homo sapiens_hsa041460.94957689
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92713989
63beta-Alanine metabolism_Homo sapiens_hsa004100.92276342
64Sulfur relay system_Homo sapiens_hsa041220.89753847
65Tyrosine metabolism_Homo sapiens_hsa003500.88448027
66Lysosome_Homo sapiens_hsa041420.86330860
67Systemic lupus erythematosus_Homo sapiens_hsa053220.85863445
68Fatty acid metabolism_Homo sapiens_hsa012120.83927660
69Fanconi anemia pathway_Homo sapiens_hsa034600.82959103
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82567056
71Non-homologous end-joining_Homo sapiens_hsa034500.79714069
72Histidine metabolism_Homo sapiens_hsa003400.79190812
73Metabolic pathways_Homo sapiens_hsa011000.79057060
74Renin-angiotensin system_Homo sapiens_hsa046140.75153376
75Chemical carcinogenesis_Homo sapiens_hsa052040.72201632
76Other glycan degradation_Homo sapiens_hsa005110.71695742
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71291508
78Epstein-Barr virus infection_Homo sapiens_hsa051690.70873652
79Glycerolipid metabolism_Homo sapiens_hsa005610.70279593
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67335930
81Fatty acid degradation_Homo sapiens_hsa000710.62281864
82Cardiac muscle contraction_Homo sapiens_hsa042600.61900387
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61623079
84Oocyte meiosis_Homo sapiens_hsa041140.61581015
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60756672
86Small cell lung cancer_Homo sapiens_hsa052220.59328680
87RNA degradation_Homo sapiens_hsa030180.57986420
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57629190
89Arachidonic acid metabolism_Homo sapiens_hsa005900.56267803
90mRNA surveillance pathway_Homo sapiens_hsa030150.54386789
91Thyroid cancer_Homo sapiens_hsa052160.52380363
92Huntingtons disease_Homo sapiens_hsa050160.49547433
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49334248
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48067250
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47970979
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47195180
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47068721
98Oxidative phosphorylation_Homo sapiens_hsa001900.46978304
99Tryptophan metabolism_Homo sapiens_hsa003800.44666461
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44347047
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.44082126
102ECM-receptor interaction_Homo sapiens_hsa045120.43490584
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41907163
104Starch and sucrose metabolism_Homo sapiens_hsa005000.41811816
105Protein digestion and absorption_Homo sapiens_hsa049740.41668902
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41044985
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39945865
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.35459778
109Sphingolipid metabolism_Homo sapiens_hsa006000.35376131
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34921770
111PPAR signaling pathway_Homo sapiens_hsa033200.34840383
112mTOR signaling pathway_Homo sapiens_hsa041500.32251415
113Phagosome_Homo sapiens_hsa041450.31966337
114Circadian rhythm_Homo sapiens_hsa047100.29129996
115Tight junction_Homo sapiens_hsa045300.27419580
116Hippo signaling pathway_Homo sapiens_hsa043900.27129556
117Steroid biosynthesis_Homo sapiens_hsa001000.27119760
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26424011
119Protein export_Homo sapiens_hsa030600.26136880
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.26099973
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25686394
122Pertussis_Homo sapiens_hsa051330.25530959
123Adherens junction_Homo sapiens_hsa045200.25411643
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24940194
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23693675
126Hedgehog signaling pathway_Homo sapiens_hsa043400.22704193
127AMPK signaling pathway_Homo sapiens_hsa041520.21285436
128Antigen processing and presentation_Homo sapiens_hsa046120.20982947
129Parkinsons disease_Homo sapiens_hsa050120.19488035
130Arginine biosynthesis_Homo sapiens_hsa002200.18527585
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18335380
132Fatty acid elongation_Homo sapiens_hsa000620.17868945

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