FOLR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.22867512
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.22867512
3modulation by symbiont of host immune response (GO:0052553)6.22867512
4positive regulation by symbiont of host defense response (GO:0052509)6.22867512
5modulation by symbiont of host defense response (GO:0052031)6.22867512
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.22867512
7regulation of interferon-beta biosynthetic process (GO:0045357)5.35750072
8negative regulation of interleukin-12 production (GO:0032695)5.35597309
9neutrophil activation involved in immune response (GO:0002283)5.29077100
10positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.06883706
11regulation of mononuclear cell migration (GO:0071675)4.96531320
12pinocytosis (GO:0006907)4.82561278
13immunoglobulin mediated immune response (GO:0016064)4.76626572
14positive regulation of interferon-alpha production (GO:0032727)4.42354297
15regulation of macrophage chemotaxis (GO:0010758)4.36136142
16glycosphingolipid catabolic process (GO:0046479)4.32077705
17regulation of interferon-alpha production (GO:0032647)4.28205192
18virion attachment to host cell (GO:0019062)4.26196579
19adhesion of symbiont to host cell (GO:0044650)4.26196579
20lymphocyte chemotaxis (GO:0048247)4.23292403
21complement activation, alternative pathway (GO:0006957)4.22152397
22macrophage activation involved in immune response (GO:0002281)4.22095052
23amyloid precursor protein catabolic process (GO:0042987)4.13430763
24regulation of cytokine secretion involved in immune response (GO:0002739)4.07661816
25regulation of vitamin D biosynthetic process (GO:0060556)4.05052521
26respiratory burst (GO:0045730)4.04493694
27oligosaccharide catabolic process (GO:0009313)4.01573059
28microglial cell activation (GO:0001774)3.97979241
29positive regulation of chemokine biosynthetic process (GO:0045080)3.96589181
30cellular extravasation (GO:0045123)3.96095882
31positive regulation of heat generation (GO:0031652)3.95051005
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.94849689
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.94154119
34response to host immune response (GO:0052572)3.94154119
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90659444
36response to peptidoglycan (GO:0032494)3.90085726
37negative regulation of nitric oxide biosynthetic process (GO:0045019)3.88876268
38positive regulation of antigen processing and presentation (GO:0002579)3.88254785
39amino sugar catabolic process (GO:0046348)3.88101480
40glycolipid catabolic process (GO:0019377)3.87027858
41myeloid dendritic cell differentiation (GO:0043011)3.82329055
42regulation of cholesterol storage (GO:0010885)3.79451896
43monocyte chemotaxis (GO:0002548)3.78749675
44regulation of fever generation (GO:0031620)3.76215227
45adhesion of symbiont to host (GO:0044406)3.75626276
46production of molecular mediator involved in inflammatory response (GO:0002532)3.74569545
47negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.69675157
48regulation of interleukin-8 biosynthetic process (GO:0045414)3.66844080
49macrophage activation (GO:0042116)3.66704686
50myeloid cell activation involved in immune response (GO:0002275)3.64228938
51regulation of podosome assembly (GO:0071801)3.60211296
52negative regulation of cytokine production involved in immune response (GO:0002719)3.55432113
53regulation of T-helper 1 cell differentiation (GO:0045625)3.55253090
54negative regulation of granulocyte differentiation (GO:0030853)3.54395778
55positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.54299911
56NIK/NF-kappaB signaling (GO:0038061)3.54261957
57response to host (GO:0075136)3.49998625
58response to host defenses (GO:0052200)3.49998625
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.49998625
60low-density lipoprotein particle clearance (GO:0034383)3.47325345
61regulation of chemokine biosynthetic process (GO:0045073)3.45998935
62N-acetylneuraminate metabolic process (GO:0006054)3.44012281
63ceramide catabolic process (GO:0046514)3.43192290
64interferon-gamma-mediated signaling pathway (GO:0060333)3.42772306
65regulation of chronic inflammatory response (GO:0002676)3.35213011
66eosinophil chemotaxis (GO:0048245)3.33998019
67myeloid dendritic cell activation (GO:0001773)3.33938578
68plasma lipoprotein particle clearance (GO:0034381)3.32097686
69basic amino acid transport (GO:0015802)3.30176960
70regulation of antigen processing and presentation (GO:0002577)3.27930881
71regulation of membrane protein ectodomain proteolysis (GO:0051043)3.26977990
72membrane lipid catabolic process (GO:0046466)3.26357213
73branching involved in labyrinthine layer morphogenesis (GO:0060670)3.25236228
74positive regulation of smooth muscle cell migration (GO:0014911)3.22556443
75triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.22410021
76cellular response to type I interferon (GO:0071357)3.22252436
77type I interferon signaling pathway (GO:0060337)3.22252436
78B cell mediated immunity (GO:0019724)3.20480069
79mast cell activation (GO:0045576)3.20131259
80regulation of vitamin metabolic process (GO:0030656)3.19461565
81lipopolysaccharide-mediated signaling pathway (GO:0031663)3.18879306
82complement activation (GO:0006956)3.18595330
83sphingolipid catabolic process (GO:0030149)3.17353637
84response to protozoan (GO:0001562)3.16912006
85response to type I interferon (GO:0034340)3.16749513
86phagocytosis, engulfment (GO:0006911)3.16634253
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14150307
88germinal center formation (GO:0002467)3.13660913
89positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.08226958
90hyaluronan catabolic process (GO:0030214)3.06476612
91regulation of B cell receptor signaling pathway (GO:0050855)3.06211020
92positive regulation of gamma-delta T cell activation (GO:0046645)3.06030103
93positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.05437879
94positive regulation of cholesterol efflux (GO:0010875)3.04248304
95defense response to protozoan (GO:0042832)3.03572756
96dendritic cell differentiation (GO:0097028)3.03062363
97positive regulation of cellular amide metabolic process (GO:0034250)3.02698589
98cellular response to lipopolysaccharide (GO:0071222)3.02613964
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01197068
100regulation of cholesterol esterification (GO:0010872)3.00820112
101cellular response to thyroid hormone stimulus (GO:0097067)2.99670504
102regulation of heat generation (GO:0031650)2.99604700
103negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.97217896
104positive regulation of leukocyte degranulation (GO:0043302)2.96792950
105response to thyroid hormone (GO:0097066)2.95346907
106positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.95253945
107positive regulation of mast cell activation (GO:0033005)2.94933881
108granulocyte activation (GO:0036230)2.94913161
109positive regulation of macrophage cytokine production (GO:0060907)2.94578158
110regulation of T-helper 2 cell differentiation (GO:0045628)2.94462941
111regulation of complement activation (GO:0030449)2.94385424
112negative regulation of myeloid cell apoptotic process (GO:0033033)2.94382587
113response to interferon-alpha (GO:0035455)2.93739865
114negative regulation of production of molecular mediator of immune response (GO:0002701)2.93646899
115lipoxygenase pathway (GO:0019372)2.92908175
116regulation of nitric oxide biosynthetic process (GO:0045428)2.92336749
117cellular response to molecule of bacterial origin (GO:0071219)2.92264108
118regulation of inflammatory response to antigenic stimulus (GO:0002861)2.91787721
119regulation of macrophage derived foam cell differentiation (GO:0010743)2.91533659
120neutrophil activation (GO:0042119)2.91127888
121intracellular pH reduction (GO:0051452)2.90764244
122negative regulation of lipid storage (GO:0010888)2.90534457
123response to muramyl dipeptide (GO:0032495)2.89795957
124negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.87503348
125eosinophil migration (GO:0072677)2.87221391
126cellular response to interferon-gamma (GO:0071346)2.87064895
127T cell migration (GO:0072678)2.86436792
128regulation of protein activation cascade (GO:2000257)2.86292820
129negative regulation of erythrocyte differentiation (GO:0045647)2.86157278
130positive regulation of sterol transport (GO:0032373)2.85748389
131positive regulation of cholesterol transport (GO:0032376)2.85748389
132positive regulation of NF-kappaB import into nucleus (GO:0042346)2.84945661
133positive regulation of mast cell degranulation (GO:0043306)2.84731663
134positive regulation of mast cell activation involved in immune response (GO:0033008)2.84731663
135adenosine receptor signaling pathway (GO:0001973)2.84553733
136complement activation, classical pathway (GO:0006958)2.84534897
137T-helper 1 type immune response (GO:0042088)2.84086697
138regulation of interleukin-12 production (GO:0032655)2.83821196
139macroautophagy (GO:0016236)2.83023420
140positive regulation of lipid storage (GO:0010884)2.82868134
141phospholipid efflux (GO:0033700)2.82455530
142G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.80341011
143regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80131733
144positive regulation of interleukin-6 production (GO:0032755)2.79985555
145regulation of mast cell degranulation (GO:0043304)2.79891607
146positive regulation of B cell differentiation (GO:0045579)2.77726496
147positive regulation of type 2 immune response (GO:0002830)2.77407248
148positive regulation of lymphocyte apoptotic process (GO:0070230)2.77276461
149amyloid precursor protein metabolic process (GO:0042982)2.76511347
150positive regulation of monocyte chemotaxis (GO:0090026)2.74900826
151positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.71146129
152positive regulation of interferon-beta production (GO:0032728)2.71096070
153regulation of macrophage cytokine production (GO:0010935)2.70994087
154positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.70626271
155low-density lipoprotein particle remodeling (GO:0034374)2.70332530
156regulation of MHC class II biosynthetic process (GO:0045346)2.68494424
157detection of molecule of bacterial origin (GO:0032490)2.68358641
158apoptotic cell clearance (GO:0043277)2.68341202
159myeloid leukocyte activation (GO:0002274)2.67810798
160Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63159756
161positive regulation of lymphocyte migration (GO:2000403)2.62410666
162positive regulation of phagocytosis (GO:0050766)2.61613743
163neutrophil chemotaxis (GO:0030593)2.60051097
164adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.56612046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.17669461
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.95879183
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.72962052
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.49185272
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.37531627
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72450196
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.61794509
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.50584332
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.40028241
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.81956066
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77304622
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.71579617
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58000790
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48316255
15GATA1_22025678_ChIP-Seq_K562_Human2.43406520
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.42774896
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.41056816
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31422343
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19736684
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19021096
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04454813
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01620767
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95258325
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94502266
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94054613
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.92557713
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90754344
28VDR_24787735_ChIP-Seq_THP-1_Human1.90175629
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88858744
30SPI1_23127762_ChIP-Seq_K562_Human1.85558579
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85447962
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.77871782
33SPI1_23547873_ChIP-Seq_NB4_Human1.72620895
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71708134
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69974797
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68690960
37RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64219763
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64054239
39PU_27001747_Chip-Seq_BMDM_Mouse1.62534329
40EGR1_19032775_ChIP-ChIP_M12_Human1.56571544
41RUNX_20019798_ChIP-Seq_JUKART_Human1.55694720
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.54971027
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54425670
44VDR_24763502_ChIP-Seq_THP-1_Human1.50355837
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49026984
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.45291711
47CLOCK_20551151_ChIP-Seq_293T_Human1.39842343
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.35626407
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33422230
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.31363714
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31145837
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29695456
53CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28564083
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27475802
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26420753
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26144232
57TFEB_21752829_ChIP-Seq_HELA_Human1.25802025
58SCL_19346495_ChIP-Seq_HPC-7_Human1.24823633
59VDR_21846776_ChIP-Seq_THP-1_Human1.24484597
60MAF_26560356_Chip-Seq_TH1_Human1.21438728
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.19951890
62GATA1_19941826_ChIP-Seq_K562_Human1.19778542
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19538042
64KDM2B_26808549_Chip-Seq_DND41_Human1.18571689
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16954113
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16554819
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15383034
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15064909
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14335128
70* STAT1_20625510_ChIP-Seq_HELA_Human1.14205963
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13013182
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12088597
73TCF7_22412390_ChIP-Seq_EML_Mouse1.11112622
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10599258
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10075521
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09839957
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.09146833
78SPI1_20517297_ChIP-Seq_HL60_Human1.09021308
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07186167
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06375093
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06300707
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04326347
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03996050
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03913133
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02910659
86BCOR_27268052_Chip-Seq_Bcells_Human1.02087793
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02039812
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02024474
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01372855
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01173764
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00191920
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00099477
93BCL6_27268052_Chip-Seq_Bcells_Human0.99825768
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99589287
95MYB_26560356_Chip-Seq_TH2_Human0.99390780
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99020228
97KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97929741
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97678482
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97443792
100GATA2_19941826_ChIP-Seq_K562_Human0.97095498
101IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96852712
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96624246
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96624246
104FOXO3_23340844_ChIP-Seq_DLD1_Human0.96562163
105LXR_22292898_ChIP-Seq_THP-1_Human0.95726959
106MAF_26560356_Chip-Seq_TH2_Human0.95211555
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.95156871
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.94991341
109SOX2_20726797_ChIP-Seq_SW620_Human0.94139551
110UTX_26944678_Chip-Seq_JUKART_Human0.93349407
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92972542
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92803698
113GATA3_26560356_Chip-Seq_TH2_Human0.92775247
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91472871
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.89888419
116KDM2B_26808549_Chip-Seq_K562_Human0.89080781
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87916739
118MYC_22102868_ChIP-Seq_BL_Human0.86234802
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84515741
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83384518
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83227862
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83211964
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79366992
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.78504200
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77549435
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.77221756
127CJUN_26792858_Chip-Seq_BT549_Human0.75655015
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.74953891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.31838964
2MP0009840_abnormal_foam_cell4.20480746
3MP0003436_decreased_susceptibility_to3.88124998
4MP0001835_abnormal_antigen_presentation3.56191703
5MP0006082_CNS_inflammation2.99085580
6MP0002148_abnormal_hypersensitivity_rea2.96995627
7MP0003191_abnormal_cellular_cholesterol2.87204102
8MP0002419_abnormal_innate_immunity2.85260018
9MP0003303_peritoneal_inflammation2.77645171
10MP0003690_abnormal_glial_cell2.65981516
11MP0005000_abnormal_immune_tolerance2.56458291
12MP0003172_abnormal_lysosome_physiology2.39903905
13MP0001533_abnormal_skeleton_physiology2.33065227
14MP0003724_increased_susceptibility_to2.27015749
15MP0009785_altered_susceptibility_to2.26036957
16MP0001790_abnormal_immune_system2.24777364
17MP0005387_immune_system_phenotype2.24777364
18MP0005025_abnormal_response_to2.21752135
19MP0000604_amyloidosis2.21070526
20MP0000343_altered_response_to2.19429153
21MP0004510_myositis2.18002463
22MP0003300_gastrointestinal_ulcer2.13002519
23MP0005464_abnormal_platelet_physiology1.97948136
24MP0001800_abnormal_humoral_immune1.95471417
25MP0000685_abnormal_immune_system1.94465522
26MP0002452_abnormal_antigen_presenting1.92434336
27MP0008004_abnormal_stomach_pH1.90647704
28MP0006054_spinal_hemorrhage1.84535195
29MP0003806_abnormal_nucleotide_metabolis1.81548393
30MP0003075_altered_response_to1.80130504
31MP0008438_abnormal_cutaneous_collagen1.77772342
32MP0005257_abnormal_intraocular_pressure1.72765766
33MP0002723_abnormal_immune_serum1.72651327
34MP0002405_respiratory_system_inflammati1.66165557
35MP0003828_pulmonary_edema1.64851362
36MP0005360_urolithiasis1.62155684
37MP0008469_abnormal_protein_level1.62052497
38MP0003453_abnormal_keratinocyte_physiol1.61478664
39MP0010329_abnormal_lipoprotein_level1.60108266
40MP0002139_abnormal_hepatobiliary_system1.58179275
41MP0009764_decreased_sensitivity_to1.57462167
42MP0001545_abnormal_hematopoietic_system1.55373716
43MP0005397_hematopoietic_system_phenotyp1.55373716
44MP0005451_abnormal_body_composition1.55175208
45MP0001845_abnormal_inflammatory_respons1.55067116
46MP0005671_abnormal_response_to1.51951184
47MP0001819_abnormal_immune_cell1.46586973
48MP0002420_abnormal_adaptive_immunity1.46115288
49MP0005083_abnormal_biliary_tract1.45704701
50MP0005310_abnormal_salivary_gland1.44118911
51MP0005365_abnormal_bile_salt1.43713130
52MP0001853_heart_inflammation1.39390959
53MP0005670_abnormal_white_adipose1.31591415
54MP0000609_abnormal_liver_physiology1.31491421
55MP0003448_altered_tumor_morphology1.29136087
56MP0004947_skin_inflammation1.27679071
57MP0003705_abnormal_hypodermis_morpholog1.25016231
58MP0010155_abnormal_intestine_physiology1.24976718
59MP0004130_abnormal_muscle_cell1.24883005
60MP0005166_decreased_susceptibility_to1.24162712
61MP0001542_abnormal_bone_strength1.23432714
62MP0009763_increased_sensitivity_to1.18273556
63MP0002998_abnormal_bone_remodeling1.17879874
64MP0000465_gastrointestinal_hemorrhage1.13719472
65MP0002332_abnormal_exercise_endurance1.13281768
66MP0002277_abnormal_respiratory_mucosa1.07035068
67MP0005085_abnormal_gallbladder_physiolo1.05124424
68MP0009333_abnormal_splenocyte_physiolog1.03872484
69MP0008875_abnormal_xenobiotic_pharmacok1.02374417
70MP0005390_skeleton_phenotype1.01946472
71MP0002118_abnormal_lipid_homeostasis0.99637021
72MP0010368_abnormal_lymphatic_system0.99365463
73MP0000689_abnormal_spleen_morphology0.99295453
74MP0005164_abnormal_response_to0.98393572
75MP0003195_calcinosis0.98392693
76MP0003566_abnormal_cell_adhesion0.96710021
77MP0000716_abnormal_immune_system0.95995030
78MP0004019_abnormal_vitamin_homeostasis0.95008010
79MP0003329_amyloid_beta_deposits0.92537862
80MP0002837_dystrophic_cardiac_calcinosis0.91944826
81MP0005319_abnormal_enzyme/_coenzyme0.91808538
82MP0000920_abnormal_myelination0.90479663
83MP0002254_reproductive_system_inflammat0.89952473
84MP0004782_abnormal_surfactant_physiolog0.89090316
85MP0001663_abnormal_digestive_system0.88957736
86MP0000249_abnormal_blood_vessel0.88533181
87MP0003186_abnormal_redox_activity0.86573317
88MP0009278_abnormal_bone_marrow0.85081525
89MP0005584_abnormal_enzyme/coenzyme_acti0.83585486
90MP0001851_eye_inflammation0.83559521
91MP0004883_abnormal_blood_vessel0.81907360
92MP0003183_abnormal_peptide_metabolism0.81284248
93MP0008260_abnormal_autophagy0.81016557
94MP0009643_abnormal_urine_homeostasis0.80532329
95MP0003656_abnormal_erythrocyte_physiolo0.77769439
96MP0002398_abnormal_bone_marrow0.77422459
97MP0002429_abnormal_blood_cell0.76963252
98MP0010307_abnormal_tumor_latency0.76898631
99MP0002166_altered_tumor_susceptibility0.76375524
100MP0005647_abnormal_sex_gland0.75887196
101MP0003634_abnormal_glial_cell0.75796462
102MP0005165_increased_susceptibility_to0.75604795
103MP0005167_abnormal_blood-brain_barrier0.74271757
104MP0000598_abnormal_liver_morphology0.73008912
105MP0002090_abnormal_vision0.72742241
106MP0009115_abnormal_fat_cell0.72417409
107MP0002722_abnormal_immune_system0.72405903
108MP0002136_abnormal_kidney_physiology0.72275085
109MP0000858_altered_metastatic_potential0.71800297
110MP0002933_joint_inflammation0.71419543
111MP0001727_abnormal_embryo_implantation0.71265466
112MP0005023_abnormal_wound_healing0.71141329
113MP0005334_abnormal_fat_pad0.71082002
114MP0005595_abnormal_vascular_smooth0.70937404
115MP0002138_abnormal_hepatobiliary_system0.70139582
116MP0003795_abnormal_bone_structure0.69641178
117MP0003091_abnormal_cell_migration0.69562530
118MP0001756_abnormal_urination0.68220286
119MP0003646_muscle_fatigue0.67074466
120MP0008874_decreased_physiological_sensi0.67015848
121MP0003279_aneurysm0.65718281
122MP0001501_abnormal_sleep_pattern0.65412357
123MP0005666_abnormal_adipose_tissue0.62865970
124MP0003879_abnormal_hair_cell0.62198513
125MP0009765_abnormal_xenobiotic_induced0.60705102
126MP0005535_abnormal_body_temperature0.57498868
127MP0001873_stomach_inflammation0.56091188

Predicted human phenotypes

RankGene SetZ-score
1Glomerulonephritis (HP:0000099)7.58674595
2Complement deficiency (HP:0004431)7.20935287
3Abnormality of complement system (HP:0005339)6.48948777
4Increased cerebral lipofuscin (HP:0011813)6.39228908
5Increased neuronal autofluorescent lipopigment (HP:0002074)6.08033474
6Vacuolated lymphocytes (HP:0001922)5.79923974
7Recurrent abscess formation (HP:0002722)5.37968484
8Recurrent bacterial skin infections (HP:0005406)5.04979199
9Dysostosis multiplex (HP:0000943)4.55667786
10Eczematoid dermatitis (HP:0000976)4.41431677
11Axonal loss (HP:0003447)4.41085715
12Nephritis (HP:0000123)4.35577173
13Nuclear cataract (HP:0100018)4.31380078
14Recurrent gram-negative bacterial infections (HP:0005420)4.26739617
15Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.24994272
16Disinhibition (HP:0000734)4.07797095
17Urinary glycosaminoglycan excretion (HP:0003541)3.65667952
18Mucopolysacchariduria (HP:0008155)3.65667952
19Spontaneous hematomas (HP:0007420)3.51712019
20Autoimmune thrombocytopenia (HP:0001973)3.50764585
21Abnormality of polysaccharide metabolism (HP:0011012)3.38288676
22Abnormality of glycosaminoglycan metabolism (HP:0004371)3.38288676
23Abnormality of mucopolysaccharide metabolism (HP:0011020)3.38288676
24Thick nail (HP:0001805)3.34514860
25Joint hemorrhage (HP:0005261)3.34210495
26Abnormality of macrophages (HP:0004311)3.32071987
27Myocardial infarction (HP:0001658)3.31709424
28Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.02257723
29Xanthomatosis (HP:0000991)2.95177462
30Abnormality of liposaccharide metabolism (HP:0010968)2.95067157
31Abnormality of glycosphingolipid metabolism (HP:0004343)2.95067157
32Abnormality of glycolipid metabolism (HP:0010969)2.95067157
33Purpura (HP:0000979)2.89081858
34Upper motor neuron abnormality (HP:0002127)2.87777647
35Agnosia (HP:0010524)2.68202685
36Neurofibrillary tangles (HP:0002185)2.67223461
37Recurrent skin infections (HP:0001581)2.63344537
38Progressive neurologic deterioration (HP:0002344)2.62014584
39Progressive visual loss (HP:0000529)2.61726707
40Gingivitis (HP:0000230)2.57811952
41Pustule (HP:0200039)2.55818720
42Mutism (HP:0002300)2.54201462
43Chronic obstructive pulmonary disease (HP:0006510)2.50762055
44Obstructive lung disease (HP:0006536)2.50762055
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.49991843
46Osteolytic defects of the hand bones (HP:0009699)2.49991843
47Myositis (HP:0100614)2.49190473
48Abnormality of the vasculature of the conjunctiva (HP:0008054)2.48135097
49Mediastinal lymphadenopathy (HP:0100721)2.47405073
50Orchitis (HP:0100796)2.42858106
51Cellulitis (HP:0100658)2.41976844
52Conjunctival telangiectasia (HP:0000524)2.40669677
53Loss of speech (HP:0002371)2.37887426
54Dementia (HP:0000726)2.37443449
55Chronic otitis media (HP:0000389)2.34199744
56Pathologic fracture (HP:0002756)2.31288903
57Hypercholesterolemia (HP:0003124)2.27480841
58Asymmetric septal hypertrophy (HP:0001670)2.26446375
59Prostate neoplasm (HP:0100787)2.26276479
60J-shaped sella turcica (HP:0002680)2.24543005
61Hepatosplenomegaly (HP:0001433)2.21934560
62Peripheral demyelination (HP:0011096)2.20878387
63Polyneuropathy (HP:0001271)2.19878677
64Metaphyseal irregularity (HP:0003025)2.18756179
65Keratoconjunctivitis sicca (HP:0001097)2.18552061
66Abnormality of the lumbar spine (HP:0100712)2.17684256
67Hyperlipoproteinemia (HP:0010980)2.15522405
68Petechiae (HP:0000967)2.15368058
69Personality changes (HP:0000751)2.12274231
70Memory impairment (HP:0002354)2.11132982
71Urticaria (HP:0001025)2.10788688
72Cerebral inclusion bodies (HP:0100314)2.09453713
73Deep venous thrombosis (HP:0002625)2.07599745
74Basal ganglia calcification (HP:0002135)2.06612907
75Abnormality of the common coagulation pathway (HP:0010990)2.04926035
76Supranuclear gaze palsy (HP:0000605)2.04728070
77Skin nodule (HP:0200036)2.04667506
78Inappropriate behavior (HP:0000719)2.01562236
79Systemic lupus erythematosus (HP:0002725)10.1442355
80Abnormality of the prostate (HP:0008775)1.99139666
81Hemoptysis (HP:0002105)1.99102370
82Retinal atrophy (HP:0001105)1.98850390
83Keratoconjunctivitis (HP:0001096)1.97113217
84Bone pain (HP:0002653)1.95707875
85Elevated erythrocyte sedimentation rate (HP:0003565)1.95032073
86Retrobulbar optic neuritis (HP:0100654)1.94845355
87Optic neuritis (HP:0100653)1.94845355
88Recurrent viral infections (HP:0004429)1.94010028
89Interstitial pulmonary disease (HP:0006530)1.92894442
90Vasculitis (HP:0002633)1.91111992
91Cardiomegaly (HP:0001640)1.89973697
92Vertebral compression fractures (HP:0002953)1.88379512
93Amyloidosis (HP:0011034)1.87484038
94Beaking of vertebral bodies (HP:0004568)1.86113593
95Increased IgM level (HP:0003496)1.85415634
96Abnormality of iron homeostasis (HP:0011031)1.85306741
97Nausea (HP:0002018)1.84938672
98Apathy (HP:0000741)1.83858877
99Thoracic kyphosis (HP:0002942)1.83829316
100Hypoalphalipoproteinemia (HP:0003233)1.83791475
101Acrocyanosis (HP:0001063)1.83256907
102Zonular cataract (HP:0010920)1.83176300
103Abnormality of the basal ganglia (HP:0002134)1.82801896
104Abnormality of the nasal mucosa (HP:0000433)1.82530268
105Hematochezia (HP:0002573)1.82245520
106Abnormality of lateral ventricle (HP:0030047)1.81742799
107Diminished motivation (HP:0000745)1.78771213
108Malnutrition (HP:0004395)1.77785997
109Periodontitis (HP:0000704)1.77499316
110Gangrene (HP:0100758)1.77017032
111Increased serum ferritin (HP:0003281)1.75020850
112Epidermoid cyst (HP:0200040)1.73116797
113Frequent falls (HP:0002359)1.72967885
114Neuronal loss in central nervous system (HP:0002529)1.71752703
115Pulmonary infiltrates (HP:0002113)1.70206454
116Prolonged neonatal jaundice (HP:0006579)1.69737766
117Bone cyst (HP:0012062)1.69726590
118Osteomyelitis (HP:0002754)1.69049168
119Recurrent pneumonia (HP:0006532)1.68678915
120Anorexia (HP:0002039)1.68564753
121Urinary incontinence (HP:0000020)1.67313775
122Recurrent fungal infections (HP:0002841)1.66826656
123Gingival bleeding (HP:0000225)1.66702248
124Abnormality of transition element cation homeostasis (HP:0011030)1.66562436
125Meningitis (HP:0001287)1.65853229
126Global brain atrophy (HP:0002283)1.65798512
127Restrictive lung disease (HP:0002091)1.65391678
128Esophageal varix (HP:0002040)1.65349871
129Mucosal telangiectasiae (HP:0100579)1.65076653
130Disproportionate tall stature (HP:0001519)1.63639144
131Stomatitis (HP:0010280)1.63246270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.46717304
2IRAK43.57222871
3TYK23.31896034
4TGFBR23.14268799
5TAOK23.00014661
6ERN12.98581913
7TBK12.98347761
8DDR22.81228343
9MAP3K142.80758400
10MAP3K112.75144924
11CAMK1D2.58148642
12EPHB12.48848879
13GRK72.48377674
14TAOK12.43760079
15IKBKE2.38332098
16KIT2.31875755
17BTK2.25025216
18RIPK41.96916222
19CSF1R1.92457494
20IRAK31.90639651
21CSK1.82958129
22JAK11.78402566
23ACVR1B1.72895493
24CAMK1G1.70308147
25HCK1.70273595
26FES1.69183339
27MAP4K11.67541591
28ZAP701.65502219
29IKBKB1.60333093
30LYN1.47341288
31TTN1.46750661
32PRPF4B1.45821614
33NEK91.37886293
34CDC42BPA1.36917174
35TRIB31.35219106
36SCYL21.34036921
37TAOK31.33081319
38SYK1.29265198
39CAMKK21.28980637
40BMX1.28708443
41FGR1.26281179
42FGFR41.23674562
43TXK1.20519015
44ADRBK21.13616352
45TEC1.13008106
46CDK61.08418729
47JAK21.06854600
48TESK11.06439643
49TESK21.06366363
50MAP3K51.06141787
51LCK1.05689643
52ABL21.05056044
53ITK1.03113897
54YES10.98831706
55DMPK0.94247361
56MAP3K130.90842895
57CAMKK10.89739313
58EPHB20.88988006
59EGFR0.83299794
60PKN20.79682782
61PIM20.77303959
62MAP2K60.76585359
63IRAK10.76178991
64CHUK0.75812141
65ABL10.75543420
66PIK3CG0.74758560
67SIK30.73922519
68TYRO30.73540574
69MAP3K30.72986821
70MARK30.72887427
71STK100.72542119
72TGFBR10.71850031
73NME20.68720376
74IRAK20.68611462
75BMPR20.67570244
76SIK10.66804333
77PTK60.65999603
78PTK2B0.65142977
79PRKCD0.64905290
80KDR0.63501316
81EPHA30.62708171
82MATK0.62231601
83MAP2K30.60447174
84PDGFRA0.59524409
85PAK40.57757931
86ICK0.57255579
87PDGFRB0.56672487
88GSK3A0.56579585
89PKN10.56529444
90DAPK30.56038529
91FGFR30.55822560
92DAPK20.53662741
93PIM10.53386891
94TNK20.53216628
95ARAF0.53167739
96JAK30.52569856
97BCKDK0.52312178
98IGF1R0.51803364
99MAP2K20.51141812
100MOS0.49389954
101FYN0.47595514
102EIF2AK20.44982324
103RIPK10.44124565
104DYRK30.44100523
105RPS6KL10.40452759
106RPS6KC10.40452759
107MAPK40.39973396
108LRRK20.39331510
109LATS20.38675188
110SRC0.38622324
111MAPK70.36515055
112STK240.35658175
113MAPKAPK20.34732958
114PBK0.32084989
115RPS6KA60.30846703
116GRK60.30003889
117MET0.28941997
118SIK20.28302742
119CLK10.27751329
120MAPK110.27475740
121PRKD10.27325912
122PDPK10.27132040
123PRKCG0.26755277
124MST1R0.26470061
125MAP3K20.25809922
126DYRK1B0.25277819
127INSR0.25098653
128PRKACG0.25000059
129MAPK120.24351020
130HIPK20.23720132
131MAP3K10.23707917
132STK30.23051862
133MARK20.22347008
134PRKAA20.22319681
135RPS6KA20.22157154
136PRKG20.21477067
137CDK40.19838527
138PDK10.18716637

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051506.52458036
2Complement and coagulation cascades_Homo sapiens_hsa046103.37039049
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.15650232
4Lysosome_Homo sapiens_hsa041423.09337429
5Leishmaniasis_Homo sapiens_hsa051402.58053303
6Pertussis_Homo sapiens_hsa051332.56555859
7Autoimmune thyroid disease_Homo sapiens_hsa053202.28880832
8Osteoclast differentiation_Homo sapiens_hsa043802.27445588
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.20118885
10Other glycan degradation_Homo sapiens_hsa005112.06510459
11Malaria_Homo sapiens_hsa051441.86993020
12Type I diabetes mellitus_Homo sapiens_hsa049401.84504835
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.83141958
14Tuberculosis_Homo sapiens_hsa051521.78051407
15Prion diseases_Homo sapiens_hsa050201.73203604
16Phagosome_Homo sapiens_hsa041451.64691819
17Caffeine metabolism_Homo sapiens_hsa002321.61292500
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60507085
19Legionellosis_Homo sapiens_hsa051341.58528791
20B cell receptor signaling pathway_Homo sapiens_hsa046621.51317315
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.47015636
22Salmonella infection_Homo sapiens_hsa051321.41098772
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37617623
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36548132
25Rheumatoid arthritis_Homo sapiens_hsa053231.32183812
26PPAR signaling pathway_Homo sapiens_hsa033201.26818590
27Toxoplasmosis_Homo sapiens_hsa051451.23735737
28Measles_Homo sapiens_hsa051621.23551363
29Asthma_Homo sapiens_hsa053101.18549136
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15543547
31Nitrogen metabolism_Homo sapiens_hsa009101.15199027
32Collecting duct acid secretion_Homo sapiens_hsa049661.14728478
33Antigen processing and presentation_Homo sapiens_hsa046121.08850120
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08135021
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07326989
36Arginine biosynthesis_Homo sapiens_hsa002201.03455599
37ABC transporters_Homo sapiens_hsa020101.01819159
38Amoebiasis_Homo sapiens_hsa051461.01205502
39Influenza A_Homo sapiens_hsa051640.97137985
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97092099
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.95227024
42Chemokine signaling pathway_Homo sapiens_hsa040620.93193483
43Shigellosis_Homo sapiens_hsa051310.92026816
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91146671
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88577474
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87813359
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85865909
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84170077
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79751384
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78536863
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77473595
52Vitamin digestion and absorption_Homo sapiens_hsa049770.77155668
53Steroid biosynthesis_Homo sapiens_hsa001000.76739609
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76378412
55Bladder cancer_Homo sapiens_hsa052190.76074976
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74883242
57Apoptosis_Homo sapiens_hsa042100.74649627
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73971194
59Starch and sucrose metabolism_Homo sapiens_hsa005000.66096224
60Vibrio cholerae infection_Homo sapiens_hsa051100.65424566
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65217674
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.65044265
63Fatty acid degradation_Homo sapiens_hsa000710.64362074
64Hepatitis C_Homo sapiens_hsa051600.63979479
65TNF signaling pathway_Homo sapiens_hsa046680.63805329
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.63357701
67Peroxisome_Homo sapiens_hsa041460.63279701
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63049438
69Allograft rejection_Homo sapiens_hsa053300.62467611
70Fat digestion and absorption_Homo sapiens_hsa049750.62176449
71Primary immunodeficiency_Homo sapiens_hsa053400.60473352
72Epstein-Barr virus infection_Homo sapiens_hsa051690.60189051
73African trypanosomiasis_Homo sapiens_hsa051430.59103374
74beta-Alanine metabolism_Homo sapiens_hsa004100.56607541
75T cell receptor signaling pathway_Homo sapiens_hsa046600.56574245
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56411418
77Histidine metabolism_Homo sapiens_hsa003400.56103391
78Retinol metabolism_Homo sapiens_hsa008300.56006044
79Fatty acid metabolism_Homo sapiens_hsa012120.55729187
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.54977445
81Platelet activation_Homo sapiens_hsa046110.54913590
82Pentose phosphate pathway_Homo sapiens_hsa000300.54164356
83Pancreatic cancer_Homo sapiens_hsa052120.54131279
84Systemic lupus erythematosus_Homo sapiens_hsa053220.53425921
85Mineral absorption_Homo sapiens_hsa049780.53286760
86Sphingolipid metabolism_Homo sapiens_hsa006000.53158966
87* Endocytosis_Homo sapiens_hsa041440.52250164
88Sulfur metabolism_Homo sapiens_hsa009200.51910122
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51122670
90Herpes simplex infection_Homo sapiens_hsa051680.50828577
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50031772
92Viral myocarditis_Homo sapiens_hsa054160.49747735
93Tryptophan metabolism_Homo sapiens_hsa003800.49650918
94Graft-versus-host disease_Homo sapiens_hsa053320.49315129
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48267480
96Hepatitis B_Homo sapiens_hsa051610.47732542
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47508444
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47069668
99Prolactin signaling pathway_Homo sapiens_hsa049170.45738299
100Arachidonic acid metabolism_Homo sapiens_hsa005900.45657880
101VEGF signaling pathway_Homo sapiens_hsa043700.43900253
102Hematopoietic cell lineage_Homo sapiens_hsa046400.43868719
103Chronic myeloid leukemia_Homo sapiens_hsa052200.43728529
104Ether lipid metabolism_Homo sapiens_hsa005650.43117287
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.41940864
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41144362
107Galactose metabolism_Homo sapiens_hsa000520.41122274
108Type II diabetes mellitus_Homo sapiens_hsa049300.40787896
109Insulin resistance_Homo sapiens_hsa049310.39472707
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38976738
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.37614779
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35824585
113Synaptic vesicle cycle_Homo sapiens_hsa047210.35448174
114Glycerolipid metabolism_Homo sapiens_hsa005610.35139758
115Renin-angiotensin system_Homo sapiens_hsa046140.34557896
116HTLV-I infection_Homo sapiens_hsa051660.33666297
117Acute myeloid leukemia_Homo sapiens_hsa052210.33191897
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32592364
119Chemical carcinogenesis_Homo sapiens_hsa052040.29405884
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28623429
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.25333983
122Glutathione metabolism_Homo sapiens_hsa004800.22763493
123HIF-1 signaling pathway_Homo sapiens_hsa040660.19337974
124Notch signaling pathway_Homo sapiens_hsa043300.13985154
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.12017161
126MAPK signaling pathway_Homo sapiens_hsa040100.08439590
127Viral carcinogenesis_Homo sapiens_hsa052030.06140787
128Fructose and mannose metabolism_Homo sapiens_hsa000510.06055907
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05409782

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