FOLR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)6.41638896
2neutrophil activation involved in immune response (GO:0002283)6.27695171
3leukocyte migration involved in inflammatory response (GO:0002523)6.13501685
4detection of other organism (GO:0098543)6.09758941
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.09327815
6negative regulation of cell killing (GO:0031342)6.09327815
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.09172668
8detection of bacterium (GO:0016045)5.99362167
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.81299462
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.81299462
11modulation by symbiont of host immune response (GO:0052553)5.81299462
12positive regulation by symbiont of host defense response (GO:0052509)5.81299462
13modulation by symbiont of host defense response (GO:0052031)5.81299462
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.81299462
15response to peptidoglycan (GO:0032494)5.38831826
16positive regulation of gamma-delta T cell activation (GO:0046645)5.35409231
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.27890907
18antigen processing and presentation of endogenous antigen (GO:0019883)5.24902430
19detection of external biotic stimulus (GO:0098581)4.99049371
20macrophage activation involved in immune response (GO:0002281)4.90334621
21neutrophil activation (GO:0042119)4.77667373
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.75373763
23cellular extravasation (GO:0045123)4.69978670
24respiratory burst (GO:0045730)4.59145321
25regulation of B cell receptor signaling pathway (GO:0050855)4.51617144
26negative regulation of interleukin-12 production (GO:0032695)4.43662198
27granulocyte activation (GO:0036230)4.38035351
28detection of biotic stimulus (GO:0009595)4.34786608
29detection of molecule of bacterial origin (GO:0032490)4.33907692
30negative regulation of lymphocyte mediated immunity (GO:0002707)4.26507924
31regulation of mast cell degranulation (GO:0043304)4.14978056
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.12835072
33response to host immune response (GO:0052572)4.12835072
34production of molecular mediator involved in inflammatory response (GO:0002532)4.12551637
35immunoglobulin mediated immune response (GO:0016064)4.11053233
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.10129422
37regulation of interferon-beta biosynthetic process (GO:0045357)3.94334130
38regulation of myeloid leukocyte mediated immunity (GO:0002886)3.88343521
39microglial cell activation (GO:0001774)3.85101864
40defense response to fungus (GO:0050832)3.84723172
41regulation of mast cell activation involved in immune response (GO:0033006)3.83419593
42myeloid cell activation involved in immune response (GO:0002275)3.83113458
43negative regulation of leukocyte mediated immunity (GO:0002704)3.79382356
44response to host (GO:0075136)3.78911262
45response to host defenses (GO:0052200)3.78911262
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.78911262
47regulation of gamma-delta T cell activation (GO:0046643)3.75682726
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.74684132
49positive regulation of mast cell activation (GO:0033005)3.74296121
50response to interleukin-15 (GO:0070672)3.70461156
51regulation of leukocyte degranulation (GO:0043300)3.67103011
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.63574917
53macrophage activation (GO:0042116)3.63370958
54neutrophil chemotaxis (GO:0030593)3.57612436
55regulation of mast cell activation (GO:0033003)3.57278698
56neutrophil mediated immunity (GO:0002446)3.56042352
57neutrophil migration (GO:1990266)3.48721227
58negative regulation of T cell mediated immunity (GO:0002710)3.48230182
59leukocyte degranulation (GO:0043299)3.46017931
60response to fungus (GO:0009620)3.38871349
61positive regulation of mast cell activation involved in immune response (GO:0033008)3.37798810
62positive regulation of mast cell degranulation (GO:0043306)3.37798810
63mast cell activation (GO:0045576)3.30448148
64negative regulation of phagocytosis (GO:0050765)3.29841501
65regulation of regulated secretory pathway (GO:1903305)3.26953102
66cellular response to interleukin-15 (GO:0071350)3.26719243
67antigen processing and presentation via MHC class Ib (GO:0002475)3.24446943
68type I interferon signaling pathway (GO:0060337)3.23983019
69cellular response to type I interferon (GO:0071357)3.23983019
70regulation of T cell tolerance induction (GO:0002664)3.23756005
71B cell mediated immunity (GO:0019724)3.22081424
72response to type I interferon (GO:0034340)3.21082273
73regulation of tolerance induction (GO:0002643)3.20902875
74negative regulation of interleukin-6 production (GO:0032715)3.20199066
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.14965194
76myeloid leukocyte mediated immunity (GO:0002444)3.14792586
77positive regulation of cellular amide metabolic process (GO:0034250)3.14227411
78regulation of T-helper 2 cell differentiation (GO:0045628)3.13003065
79response to muramyl dipeptide (GO:0032495)3.12729119
80lipopolysaccharide-mediated signaling pathway (GO:0031663)3.12000551
81positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.11991430
82regulation of gamma-delta T cell differentiation (GO:0045586)3.11458070
83defense response to protozoan (GO:0042832)3.07780974
84myeloid leukocyte activation (GO:0002274)3.07741012
85B cell receptor signaling pathway (GO:0050853)3.06686295
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.05503988
87interferon-gamma-mediated signaling pathway (GO:0060333)3.04400581
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00701103
89negative regulation of T-helper cell differentiation (GO:0045623)3.00701103
90germinal center formation (GO:0002467)2.97320331
91granulocyte chemotaxis (GO:0071621)2.97212618
92regulation of B cell differentiation (GO:0045577)2.97012920
93negative regulation of cytokine production involved in immune response (GO:0002719)2.96981232
94negative regulation of innate immune response (GO:0045824)2.90938530
95regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90661452
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90156931
97superoxide anion generation (GO:0042554)2.88956618
98dendritic cell migration (GO:0036336)2.88538633
99granulocyte migration (GO:0097530)2.88472136
100positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.88364491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.01760110
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.61907132
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.39061372
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.83762169
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.33953201
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.28812712
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.27948274
8SPI1_23547873_ChIP-Seq_NB4_Human2.96689927
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95664256
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.89730766
11VDR_21846776_ChIP-Seq_THP-1_Human2.81313760
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77752606
13VDR_24763502_ChIP-Seq_THP-1_Human2.76838778
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73660202
15SPI1_23127762_ChIP-Seq_K562_Human2.68274260
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.66514106
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55018719
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52116504
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49914300
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40681771
21RUNX_20019798_ChIP-Seq_JUKART_Human2.35900247
22MAF_26560356_Chip-Seq_TH1_Human2.34501154
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.30570123
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23277707
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13837484
26UTX_26944678_Chip-Seq_JUKART_Human2.13382557
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12662311
28* MYB_26560356_Chip-Seq_TH2_Human2.07394747
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03131283
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00997863
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95440725
32SCL_19346495_ChIP-Seq_HPC-7_Human1.94647982
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94595395
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.89905039
35TCF7_22412390_ChIP-Seq_EML_Mouse1.85633311
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85584218
37MYC_22102868_ChIP-Seq_BL_Human1.82336558
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80488887
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.80123724
40VDR_24787735_ChIP-Seq_THP-1_Human1.79007700
41* MYB_26560356_Chip-Seq_TH1_Human1.78710398
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77977687
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69594428
44MAF_26560356_Chip-Seq_TH2_Human1.69569732
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66162074
46KDM2B_26808549_Chip-Seq_DND41_Human1.63604010
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61109945
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59453115
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58552903
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54587109
51PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54023049
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53853440
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52905306
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.52335776
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.52223515
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50557550
57GATA3_27048872_Chip-Seq_THYMUS_Human1.50491514
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.45675197
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45128744
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42184332
61LXR_22292898_ChIP-Seq_THP-1_Human1.38149620
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38049850
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36912528
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35301356
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33533137
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31196619
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31100078
68PU_27001747_Chip-Seq_BMDM_Mouse1.28583526
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28138741
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27276610
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26459976
72* GATA3_26560356_Chip-Seq_TH2_Human1.23181918
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21756658
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21527451
75GATA1_19941826_ChIP-Seq_K562_Human1.17731839
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17048893
77BCL6_27268052_Chip-Seq_Bcells_Human1.16383900
78BCOR_27268052_Chip-Seq_Bcells_Human1.15812890
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13924961
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12214622
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11723438
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11603006
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11585009
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07606594
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07525042
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.07236658
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06067127
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.03361764
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01543860
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95900656
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95883079
92GATA1_22025678_ChIP-Seq_K562_Human0.95227779
93SPI1_20517297_ChIP-Seq_HL60_Human0.94344231
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91836406
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91552361
96NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90254103
97GATA2_19941826_ChIP-Seq_K562_Human0.88427980
98NCOR1_26117541_ChIP-Seq_K562_Human0.88038235
99RACK7_27058665_Chip-Seq_MCF-7_Human0.84777146
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82274895

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.27971365
2MP0003436_decreased_susceptibility_to4.49384463
3MP0003303_peritoneal_inflammation3.83168867
4MP0001835_abnormal_antigen_presentation3.53596876
5MP0002419_abnormal_innate_immunity3.49924081
6MP0009785_altered_susceptibility_to3.33461320
7MP0005025_abnormal_response_to3.12406317
8MP0003191_abnormal_cellular_cholesterol2.87091226
9MP0005387_immune_system_phenotype2.84660947
10MP0001790_abnormal_immune_system2.84660947
11MP0005000_abnormal_immune_tolerance2.84364509
12MP0006082_CNS_inflammation2.82978948
13MP0005671_abnormal_response_to2.76127071
14MP0001800_abnormal_humoral_immune2.73507618
15MP0000685_abnormal_immune_system2.68833894
16MP0002723_abnormal_immune_serum2.55303904
17MP0002420_abnormal_adaptive_immunity2.52340134
18MP0002452_abnormal_antigen_presenting2.49865453
19MP0001819_abnormal_immune_cell2.49412823
20MP0002148_abnormal_hypersensitivity_rea2.44907700
21MP0008260_abnormal_autophagy2.44785426
22MP0001533_abnormal_skeleton_physiology2.37708491
23MP0003300_gastrointestinal_ulcer2.35482047
24MP0005464_abnormal_platelet_physiology2.12934373
25MP0002405_respiratory_system_inflammati1.99993703
26MP0003172_abnormal_lysosome_physiology1.90814989
27MP0001845_abnormal_inflammatory_respons1.86786067
28MP0003828_pulmonary_edema1.83451963
29MP0002132_abnormal_respiratory_system1.83338203
30MP0000716_abnormal_immune_system1.80191659
31MP0002398_abnormal_bone_marrow1.78268906
32MP0009278_abnormal_bone_marrow1.73686482
33MP0004947_skin_inflammation1.70358421
34MP0010155_abnormal_intestine_physiology1.70014300
35MP0003763_abnormal_thymus_physiology1.69078486
36MP0002277_abnormal_respiratory_mucosa1.64482734
37MP0008469_abnormal_protein_level1.53356082
38MP0003183_abnormal_peptide_metabolism1.53217586
39MP0009764_decreased_sensitivity_to1.51321605
40MP0000465_gastrointestinal_hemorrhage1.51277688
41MP0002396_abnormal_hematopoietic_system1.50297643
42MP0009333_abnormal_splenocyte_physiolog1.48063369
43MP0002722_abnormal_immune_system1.47961088
44MP0000689_abnormal_spleen_morphology1.47654765
45MP0004883_abnormal_blood_vessel1.45323864
46MP0003806_abnormal_nucleotide_metabolis1.44783449
47MP0002429_abnormal_blood_cell1.42346320
48MP0005058_abnormal_lysosome_morphology1.41788517
49MP0004381_abnormal_hair_follicle1.41350868
50MP0000858_altered_metastatic_potential1.40632101
51MP0001851_eye_inflammation1.39584152
52MP0003075_altered_response_to1.38444807
53MP0003866_abnormal_defecation1.36189128
54MP0004510_myositis1.31894461
55MP0005397_hematopoietic_system_phenotyp1.30307619
56MP0001545_abnormal_hematopoietic_system1.30307619
57MP0005310_abnormal_salivary_gland1.27246908
58MP0002998_abnormal_bone_remodeling1.26136597
59MP0005164_abnormal_response_to1.25518718
60MP0005451_abnormal_body_composition1.22087311
61MP0000703_abnormal_thymus_morphology1.20747752
62MP0003690_abnormal_glial_cell1.16978026
63MP0000343_altered_response_to1.10214289
64MP0005166_decreased_susceptibility_to0.99254943
65MP0005390_skeleton_phenotype0.98582091
66MP0003448_altered_tumor_morphology0.90614377
67MP0009763_increased_sensitivity_to0.90167364
68MP0008004_abnormal_stomach_pH0.87004950
69MP0009840_abnormal_foam_cell0.85720566
70MP0000604_amyloidosis0.84566652
71MP0000490_abnormal_crypts_of0.79175582
72MP0001663_abnormal_digestive_system0.77335689
73MP0001853_heart_inflammation0.74221572
74MP0001958_emphysema0.74190346
75MP0003795_abnormal_bone_structure0.74133201
76MP0003656_abnormal_erythrocyte_physiolo0.73439520
77MP0005075_abnormal_melanosome_morpholog0.72604284
78MP0005083_abnormal_biliary_tract0.72123839
79MP0003566_abnormal_cell_adhesion0.71511627
80MP0009765_abnormal_xenobiotic_induced0.69527946
81MP0003045_fibrosis0.68863333
82MP0008874_decreased_physiological_sensi0.66591550
83MP0001986_abnormal_taste_sensitivity0.66204174
84MP0002166_altered_tumor_susceptibility0.63754316
85MP0005319_abnormal_enzyme/_coenzyme0.62423747
86MP0002933_joint_inflammation0.61025966
87MP0000249_abnormal_blood_vessel0.59862378
88MP0004808_abnormal_hematopoietic_stem0.59778168
89MP0002138_abnormal_hepatobiliary_system0.56714410
90MP0001542_abnormal_bone_strength0.55510484
91MP0003221_abnormal_cardiomyocyte_apopto0.54674549
92MP0005388_respiratory_system_phenotype0.54202019
93MP0002133_abnormal_respiratory_system0.54202019
94MP0000015_abnormal_ear_pigmentation0.54112487
95MP0000920_abnormal_myelination0.53671029
96MP0004858_abnormal_nervous_system0.52409912
97MP0003453_abnormal_keratinocyte_physiol0.52243421
98MP0003091_abnormal_cell_migration0.52085451
99MP0005377_hearing/vestibular/ear_phenot0.51230633
100MP0003878_abnormal_ear_physiology0.51230633

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.28981846
2Recurrent abscess formation (HP:0002722)6.82151036
3Recurrent bacterial skin infections (HP:0005406)6.51578865
4Abnormality of macrophages (HP:0004311)6.21832882
5Myositis (HP:0100614)5.83024205
6Recurrent gram-negative bacterial infections (HP:0005420)5.57150047
7Stomatitis (HP:0010280)5.38431566
8Orchitis (HP:0100796)5.37210503
9Optic neuritis (HP:0100653)4.98824731
10Retrobulbar optic neuritis (HP:0100654)4.98824731
11Chronic obstructive pulmonary disease (HP:0006510)4.44028371
12Obstructive lung disease (HP:0006536)4.44028371
13Elevated erythrocyte sedimentation rate (HP:0003565)4.37421354
14Mediastinal lymphadenopathy (HP:0100721)4.33227272
15Gastrointestinal infarctions (HP:0005244)4.14826663
16Recurrent skin infections (HP:0001581)4.10054779
17Recurrent fungal infections (HP:0002841)4.02556334
18Meningitis (HP:0001287)3.93236025
19Gingivitis (HP:0000230)3.89162212
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.88777682
21Urticaria (HP:0001025)3.85103197
22Keratoconjunctivitis sicca (HP:0001097)3.74005072
23Hypochromic microcytic anemia (HP:0004840)3.61632619
24Increased IgE level (HP:0003212)3.51675246
25Encephalitis (HP:0002383)3.45177287
26Keratoconjunctivitis (HP:0001096)3.44594594
27Recurrent cutaneous fungal infections (HP:0011370)3.33090488
28Chronic mucocutaneous candidiasis (HP:0002728)3.33090488
29Prolonged bleeding time (HP:0003010)3.32689320
30Spontaneous hematomas (HP:0007420)3.31197254
31Episodic fever (HP:0001954)3.26640906
32Cellulitis (HP:0100658)3.25219984
33Vasculitis (HP:0002633)3.22282599
34Hypochromic anemia (HP:0001931)3.13444343
35Petechiae (HP:0000967)3.08812429
36Anorexia (HP:0002039)2.98086929
37Gingival bleeding (HP:0000225)2.97356393
38Chest pain (HP:0100749)2.94345166
39Pulmonary infiltrates (HP:0002113)2.92334709
40Hemoptysis (HP:0002105)2.87422115
41Abnormality of glycolipid metabolism (HP:0010969)2.87258966
42Abnormality of liposaccharide metabolism (HP:0010968)2.87258966
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.87258966
44Peritonitis (HP:0002586)2.84828501
45Pustule (HP:0200039)2.73620616
46Epistaxis (HP:0000421)2.70139043
47Amyloidosis (HP:0011034)2.65354578
48Osteomyelitis (HP:0002754)2.63792112
49Inflammation of the large intestine (HP:0002037)2.59758885
50Leukocytosis (HP:0001974)2.59456236
51T lymphocytopenia (HP:0005403)2.56135928
52Increased IgM level (HP:0003496)2.55462296
53Increased cerebral lipofuscin (HP:0011813)2.53898003
54Arterial thrombosis (HP:0004420)2.53339411
55Gastrointestinal inflammation (HP:0004386)2.50115043
56Abnormality of T cell number (HP:0011839)2.49030542
57Hepatosplenomegaly (HP:0001433)2.48051804
58Purpura (HP:0000979)2.46765144
59Sepsis (HP:0100806)2.42685643
60Recurrent viral infections (HP:0004429)2.42317295
61Pulmonary embolism (HP:0002204)2.40332494
62Premature loss of primary teeth (HP:0006323)2.39363333
63Loss of speech (HP:0002371)2.34427797
64Abnormality of T cells (HP:0002843)2.31479563
65Panhypogammaglobulinemia (HP:0003139)2.31009520
66Microcytic anemia (HP:0001935)2.28927016
67Increased serum ferritin (HP:0003281)2.27613700
68Granulocytopenia (HP:0001913)2.27603966
69Hypergammaglobulinemia (HP:0010702)2.27511777
70Gangrene (HP:0100758)2.23019582
71Disinhibition (HP:0000734)2.22862833
72Skin ulcer (HP:0200042)2.21407695
73Abnormality of the pleura (HP:0002103)2.18676253
74Abnormality of iron homeostasis (HP:0011031)2.15435447
75Lymphopenia (HP:0001888)2.14370471
76Abnormality of T cell physiology (HP:0011840)2.10576805
77Abnormality of the peritoneum (HP:0002585)2.09082638
78Metaphyseal cupping (HP:0003021)2.08304104
79Abnormal platelet volume (HP:0011876)2.06806507
80Interstitial pulmonary disease (HP:0006530)2.06451271
81Colitis (HP:0002583)2.04410872
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.04395980
83Abnormality of cells of the lymphoid lineage (HP:0012140)1.99765729
84Abnormality of the pericardium (HP:0001697)1.98213892
85Slow saccadic eye movements (HP:0000514)1.97580183
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96785815
87Abnormality of the endocardium (HP:0004306)1.95703779
88Difficulty running (HP:0009046)1.95088286
89Hypermelanotic macule (HP:0001034)1.95029440
90Acne (HP:0001061)1.94529492
91Recurrent pneumonia (HP:0006532)1.94200615
92Glomerulopathy (HP:0100820)1.93849905
93Vertigo (HP:0002321)1.92392433
94Keratitis (HP:0000491)1.88537663
95Abnormality of the heme biosynthetic pathway (HP:0010472)1.85894145
96Cheilitis (HP:0100825)1.81889952
97Eosinophilia (HP:0001880)1.80934515
98Skin rash (HP:0000988)1.79493488
99Systemic lupus erythematosus (HP:0002725)1.79280588
100Pathologic fracture (HP:0002756)1.78396605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.41302057
2MAP2K33.58102430
3IRAK43.29895257
4BLK3.21485409
5MAP4K13.17867713
6ERN12.95698383
7CSK2.90499164
8FES2.70504155
9TYK22.68688606
10GRK62.47833578
11TNK22.38955546
12EPHB12.26806544
13MAP3K32.20510843
14FGR2.18465235
15ZAP702.15998841
16TAOK12.15474783
17PRPF4B2.03077195
18BTK1.84524164
19HCK1.82602686
20MAP3K111.72977980
21JAK31.67329052
22SYK1.63304320
23LYN1.45686259
24TXK1.39333044
25SIK31.38299332
26JAK21.36485721
27YES11.29670366
28KSR21.29317994
29TBK11.27668197
30MAP3K141.27087498
31MAP3K11.26827106
32MAP3K61.26108038
33IKBKE1.24218634
34CSF1R1.21842809
35JAK11.17259060
36TAOK21.16914387
37MAP3K131.15896064
38LCK1.13499790
39MARK31.06237062
40PRKD21.04866724
41PTK61.03962356
42MARK20.98888367
43TESK20.97012858
44ITK0.96667906
45KIT0.95406921
46STK100.94088991
47TEC0.92112892
48PDK10.88086567
49TGFBR20.87797010
50PDPK10.86405495
51MATK0.84857916
52TRIB30.81561990
53SIK20.79022497
54CDK190.78047574
55MAP2K40.76261778
56IRAK20.76182056
57FYN0.76078020
58PTK2B0.75965700
59IRAK10.74596450
60BMPR20.73544947
61TAOK30.73274837
62IKBKB0.73031283
63MAP3K50.72129516
64LRRK20.70729085
65SMG10.67275909
66SIK10.61502608
67MAP3K20.60446686
68CDC42BPA0.58571940
69MAPK120.56268971
70MAP2K60.55934560
71STK110.55920030
72STK380.54204562
73GRK70.53288680
74MAP3K70.52913109
75DYRK1B0.51846697
76RET0.49470033
77SGK30.48883106
78PIK3CG0.47537443
79RPS6KL10.47244848
80RPS6KC10.47244848
81PRKCQ0.46041764
82PRKG20.45170286
83RAF10.44956450
84EPHA30.44577366
85MAPKAPK20.43844565
86MAPK70.40933105
87MOS0.40482249
88DAPK20.39669084
89PRKCD0.39243706
90RPS6KA60.38495872
91BMX0.38045665
92KSR10.37965848
93HIPK20.34438454
94MAP3K80.33672543
95FGFR40.33460663
96PIM10.32983839
97ALK0.32811815
98PRKCZ0.31836034
99FGFR30.31535830
100ABL10.28063595

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.32413910
2Osteoclast differentiation_Homo sapiens_hsa043803.24658272
3Leishmaniasis_Homo sapiens_hsa051403.06877016
4Staphylococcus aureus infection_Homo sapiens_hsa051502.98709586
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.32422721
6Tuberculosis_Homo sapiens_hsa051522.27841160
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.21958124
8Graft-versus-host disease_Homo sapiens_hsa053322.14598565
9B cell receptor signaling pathway_Homo sapiens_hsa046622.11445170
10Malaria_Homo sapiens_hsa051442.07459928
11Allograft rejection_Homo sapiens_hsa053302.07000091
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99342009
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99078614
14Autoimmune thyroid disease_Homo sapiens_hsa053201.89884354
15Legionellosis_Homo sapiens_hsa051341.77162557
16Hematopoietic cell lineage_Homo sapiens_hsa046401.76307580
17Primary immunodeficiency_Homo sapiens_hsa053401.70952509
18Phagosome_Homo sapiens_hsa041451.69872884
19Chemokine signaling pathway_Homo sapiens_hsa040621.67630049
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64431018
21Measles_Homo sapiens_hsa051621.60286040
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59976005
23Acute myeloid leukemia_Homo sapiens_hsa052211.55930300
24Other glycan degradation_Homo sapiens_hsa005111.53215521
25Antigen processing and presentation_Homo sapiens_hsa046121.51617448
26Toxoplasmosis_Homo sapiens_hsa051451.50632131
27Type I diabetes mellitus_Homo sapiens_hsa049401.48563625
28Viral myocarditis_Homo sapiens_hsa054161.45203346
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.41858178
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.38533144
31Influenza A_Homo sapiens_hsa051641.37395877
32T cell receptor signaling pathway_Homo sapiens_hsa046601.34483357
33African trypanosomiasis_Homo sapiens_hsa051431.31687769
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31455033
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.27274896
36Salmonella infection_Homo sapiens_hsa051321.26861533
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25390475
38TNF signaling pathway_Homo sapiens_hsa046681.20902424
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19498038
40Herpes simplex infection_Homo sapiens_hsa051681.18437843
41Lysosome_Homo sapiens_hsa041421.17743260
42Pertussis_Homo sapiens_hsa051331.16737256
43Shigellosis_Homo sapiens_hsa051311.16397199
44Platelet activation_Homo sapiens_hsa046111.13622042
45Rheumatoid arthritis_Homo sapiens_hsa053231.13028606
46Asthma_Homo sapiens_hsa053101.08339900
47Non-small cell lung cancer_Homo sapiens_hsa052231.05205995
48Hepatitis B_Homo sapiens_hsa051610.99158155
49Hepatitis C_Homo sapiens_hsa051600.98166361
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.96160027
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96078207
52VEGF signaling pathway_Homo sapiens_hsa043700.91787844
53Pancreatic cancer_Homo sapiens_hsa052120.91441008
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88291246
55Apoptosis_Homo sapiens_hsa042100.87792111
56Amoebiasis_Homo sapiens_hsa051460.84966145
57* Endocytosis_Homo sapiens_hsa041440.82718126
58Chronic myeloid leukemia_Homo sapiens_hsa052200.81812206
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78817433
60Collecting duct acid secretion_Homo sapiens_hsa049660.77376173
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75533944
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.75479352
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74532466
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74382611
65Renal cell carcinoma_Homo sapiens_hsa052110.72504871
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71829948
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.70998438
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.70187010
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69723589
70Prolactin signaling pathway_Homo sapiens_hsa049170.67034860
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.64036298
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.63940671
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63856856
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63455605
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61541421
76Notch signaling pathway_Homo sapiens_hsa043300.60866827
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60791226
78HIF-1 signaling pathway_Homo sapiens_hsa040660.59581541
79Epstein-Barr virus infection_Homo sapiens_hsa051690.56870476
80FoxO signaling pathway_Homo sapiens_hsa040680.55935001
81GnRH signaling pathway_Homo sapiens_hsa049120.55638616
82Type II diabetes mellitus_Homo sapiens_hsa049300.55421021
83Viral carcinogenesis_Homo sapiens_hsa052030.54086103
84Endometrial cancer_Homo sapiens_hsa052130.52789410
85Regulation of autophagy_Homo sapiens_hsa041400.52653721
86Choline metabolism in cancer_Homo sapiens_hsa052310.49341678
87Galactose metabolism_Homo sapiens_hsa000520.48930479
88Rap1 signaling pathway_Homo sapiens_hsa040150.48095796
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45849611
90HTLV-I infection_Homo sapiens_hsa051660.42564230
91Insulin resistance_Homo sapiens_hsa049310.41479172
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41248722
93MAPK signaling pathway_Homo sapiens_hsa040100.41162705
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40935477
95mTOR signaling pathway_Homo sapiens_hsa041500.39489590
96Inositol phosphate metabolism_Homo sapiens_hsa005620.39467195
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.39370331
98Colorectal cancer_Homo sapiens_hsa052100.38234288
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38188515
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35821195

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