FOPNL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.65631464
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.27099878
3ATP synthesis coupled proton transport (GO:0015986)6.27099878
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.99336614
5chaperone-mediated protein transport (GO:0072321)5.18758631
6respiratory electron transport chain (GO:0022904)5.16972838
7mitochondrial respiratory chain complex I assembly (GO:0032981)5.05652553
8NADH dehydrogenase complex assembly (GO:0010257)5.05652553
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.05652553
10electron transport chain (GO:0022900)5.03720196
11protein neddylation (GO:0045116)4.96559780
12protein complex biogenesis (GO:0070271)4.78869476
13mitochondrial respiratory chain complex assembly (GO:0033108)4.23979304
14ribosome assembly (GO:0042255)4.22625290
15cullin deneddylation (GO:0010388)4.10188994
16central nervous system myelination (GO:0022010)4.07515758
17axon ensheathment in central nervous system (GO:0032291)4.07515758
18CENP-A containing nucleosome assembly (GO:0034080)4.05309218
19protein deneddylation (GO:0000338)3.91856969
20chromatin remodeling at centromere (GO:0031055)3.91806700
21respiratory chain complex IV assembly (GO:0008535)3.84446607
22proteasome assembly (GO:0043248)3.82036108
23mannosylation (GO:0097502)3.79535039
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.79308310
25L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.70323961
26establishment of integrated proviral latency (GO:0075713)3.69814105
27purine nucleobase biosynthetic process (GO:0009113)3.67687510
28rRNA modification (GO:0000154)3.58226388
29long-chain fatty acid biosynthetic process (GO:0042759)3.57197556
30protein K6-linked ubiquitination (GO:0085020)3.55585791
31termination of RNA polymerase III transcription (GO:0006386)3.54833640
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.54833640
33DNA double-strand break processing (GO:0000729)3.54603995
34DNA replication checkpoint (GO:0000076)3.53097919
35pseudouridine synthesis (GO:0001522)3.53024378
36IMP biosynthetic process (GO:0006188)3.47798462
37presynaptic membrane assembly (GO:0097105)3.44821855
38nucleobase biosynthetic process (GO:0046112)3.44645242
39telomere maintenance via semi-conservative replication (GO:0032201)3.38731999
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.38400825
41histone exchange (GO:0043486)3.37822019
42GTP biosynthetic process (GO:0006183)3.37036797
43DNA strand elongation involved in DNA replication (GO:0006271)3.34503037
44positive regulation of ligase activity (GO:0051351)3.32172727
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25510853
46cytochrome complex assembly (GO:0017004)3.25148155
47viral protein processing (GO:0019082)3.24876481
48protein localization to kinetochore (GO:0034501)3.24579271
49fatty acid elongation (GO:0030497)3.24083060
50presynaptic membrane organization (GO:0097090)3.24003587
51mitotic metaphase plate congression (GO:0007080)3.22549152
52DNA strand elongation (GO:0022616)3.21589131
53positive regulation of protein homodimerization activity (GO:0090073)3.19051243
547-methylguanosine mRNA capping (GO:0006370)3.16882753
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15971454
56DNA catabolic process, exonucleolytic (GO:0000738)3.15853974
577-methylguanosine RNA capping (GO:0009452)3.14689552
58RNA capping (GO:0036260)3.14689552
59hydrogen ion transmembrane transport (GO:1902600)3.13726642
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13018640
61establishment of viral latency (GO:0019043)3.12863444
62IMP metabolic process (GO:0046040)3.12292351
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12233157
64dopamine transport (GO:0015872)3.09408846
65regulation of ubiquitin-protein transferase activity (GO:0051438)3.08253931
66DNA ligation (GO:0006266)3.08019897
67positive regulation of mitochondrial fission (GO:0090141)3.07959385
68metaphase plate congression (GO:0051310)3.07938936
69ribosomal large subunit biogenesis (GO:0042273)3.07632090
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.07057929
71regulation of centriole replication (GO:0046599)3.06603470
72regulation of cellular amino acid metabolic process (GO:0006521)3.05981178
73rRNA methylation (GO:0031167)3.05495793
74purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04989831
75mitotic recombination (GO:0006312)3.04670322
76regulation of ligase activity (GO:0051340)3.04365871
77telomere maintenance via recombination (GO:0000722)3.03040395
78inner mitochondrial membrane organization (GO:0007007)3.02798509
79GPI anchor biosynthetic process (GO:0006506)3.01782795
80regulation of mitochondrial translation (GO:0070129)3.01418568
81DNA replication-independent nucleosome assembly (GO:0006336)3.00592670
82DNA replication-independent nucleosome organization (GO:0034724)3.00592670
83neuron cell-cell adhesion (GO:0007158)2.99703993
84purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99660544
85maturation of 5.8S rRNA (GO:0000460)2.98471787
86oxidative phosphorylation (GO:0006119)2.98318034
87formation of translation preinitiation complex (GO:0001731)2.98110316
88transcription-coupled nucleotide-excision repair (GO:0006283)2.97706691
89tRNA aminoacylation (GO:0043039)2.96863948
90amino acid activation (GO:0043038)2.96863948
91folic acid-containing compound biosynthetic process (GO:0009396)2.96195602
92tRNA aminoacylation for protein translation (GO:0006418)2.96006615
93ATP biosynthetic process (GO:0006754)2.95833556
94ribosomal small subunit biogenesis (GO:0042274)2.95682186
95substantia nigra development (GO:0021762)2.95318704
96deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95270138
97proton transport (GO:0015992)2.94811093
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94712693
99kinetochore organization (GO:0051383)2.94498324
100regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.93501649
101regulation of mitotic spindle checkpoint (GO:1903504)2.93501649
102organelle disassembly (GO:1903008)2.93062842
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92512475
104negative regulation of ligase activity (GO:0051352)2.92512475
105somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91647924
106somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91647924
107isotype switching (GO:0045190)2.91647924
108protein targeting to mitochondrion (GO:0006626)2.90952540
109spindle checkpoint (GO:0031577)2.90219263
110cell cycle G1/S phase transition (GO:0044843)2.90006027
111G1/S transition of mitotic cell cycle (GO:0000082)2.90006027
112replication fork processing (GO:0031297)2.87094721
113mitotic G2/M transition checkpoint (GO:0044818)2.86511683
114guanosine-containing compound biosynthetic process (GO:1901070)2.86313304
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85691160
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85691160
117hydrogen transport (GO:0006818)2.85577344
118mitotic spindle checkpoint (GO:0071174)2.85044074
119signal peptide processing (GO:0006465)2.84645872
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83607315
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83607315
122signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83607315
123mitotic sister chromatid segregation (GO:0000070)2.82855845
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82604551
125mitochondrial RNA metabolic process (GO:0000959)2.82467017
126positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81877157
127protein prenylation (GO:0018342)2.81527431
128prenylation (GO:0097354)2.81527431
129ubiquinone metabolic process (GO:0006743)2.80346474
130aerobic respiration (GO:0009060)2.79984482
131cotranslational protein targeting to membrane (GO:0006613)2.78096878
132quinone biosynthetic process (GO:1901663)2.75981005
133ubiquinone biosynthetic process (GO:0006744)2.75981005
134establishment of protein localization to mitochondrion (GO:0072655)2.73921760
135nucleotide transmembrane transport (GO:1901679)2.72397158
136signal transduction involved in cell cycle checkpoint (GO:0072395)2.69938755
137GPI anchor metabolic process (GO:0006505)2.69812262
138signal transduction involved in DNA damage checkpoint (GO:0072422)2.69071089
139signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69071089
140limb bud formation (GO:0060174)2.67062127
141protein localization to endoplasmic reticulum (GO:0070972)2.66043169
142regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.65689905
143mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.65168964
144protein targeting to ER (GO:0045047)2.64638611
145SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64192602
146peptidyl-histidine modification (GO:0018202)2.64112219
147regulation of collateral sprouting (GO:0048670)2.62499203
148deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.62022514
149L-methionine salvage (GO:0071267)2.60558800
150L-methionine biosynthetic process (GO:0071265)2.60558800
151amino acid salvage (GO:0043102)2.60558800
152ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60472726
153protein localization to mitochondrion (GO:0070585)2.57268663
154regulation of neuron projection regeneration (GO:0070570)2.55419514
155regulation of axon regeneration (GO:0048679)2.55419514
156tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54851275
157RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54851275
158preassembly of GPI anchor in ER membrane (GO:0016254)2.53758370
159antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.53286857
160regulation of dopamine metabolic process (GO:0042053)2.52872281
161regulation of catecholamine metabolic process (GO:0042069)2.52872281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.58813971
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.59171107
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69506237
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68759541
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.41502226
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10045440
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97466179
8GBX2_23144817_ChIP-Seq_PC3_Human2.96728227
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.90457369
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79261539
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.74689386
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73642804
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68408908
14TAF15_26573619_Chip-Seq_HEK293_Human2.67158057
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64693784
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.55430152
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50492668
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46656827
19EZH2_22144423_ChIP-Seq_EOC_Human2.42409966
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35569442
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26024137
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24448615
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20594268
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.16163412
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15695099
26PADI4_21655091_ChIP-ChIP_MCF-7_Human2.06913671
27SRF_21415370_ChIP-Seq_HL-1_Mouse2.05331708
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03531512
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02686206
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01759653
31FUS_26573619_Chip-Seq_HEK293_Human1.95362832
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94453745
33VDR_22108803_ChIP-Seq_LS180_Human1.94337258
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88634561
35AR_21909140_ChIP-Seq_LNCAP_Human1.86626822
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86573579
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86341623
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72714916
39ELK1_19687146_ChIP-ChIP_HELA_Human1.70028422
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.69592700
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64689024
42VDR_23849224_ChIP-Seq_CD4+_Human1.61186501
43ER_23166858_ChIP-Seq_MCF-7_Human1.59153781
44IRF1_19129219_ChIP-ChIP_H3396_Human1.58698650
45GABP_19822575_ChIP-Seq_HepG2_Human1.58166966
46IGF1R_20145208_ChIP-Seq_DFB_Human1.57501736
47EWS_26573619_Chip-Seq_HEK293_Human1.57151054
48P300_19829295_ChIP-Seq_ESCs_Human1.55445449
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55311792
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.53980780
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50883336
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48200875
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47812130
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45841315
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45655093
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44636053
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43212302
58XRN2_22483619_ChIP-Seq_HELA_Human1.40346791
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.40226915
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36588407
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35278942
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33251440
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.30862694
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30741020
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.30090389
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28495804
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27980547
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26922908
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.26774615
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26043270
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.25723826
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25031420
73DCP1A_22483619_ChIP-Seq_HELA_Human1.23413227
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23356984
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.22623337
76FOXP3_21729870_ChIP-Seq_TREG_Human1.22542208
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21259178
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20920190
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20815971
80RNF2_27304074_Chip-Seq_NSC_Mouse1.20642137
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20445608
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18866164
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17204683
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16929184
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16106355
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15552316
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14931230
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13990570
89KDM5A_27292631_Chip-Seq_BREAST_Human1.13040993
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.12295853
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10081470
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08678855
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07330760
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06361466
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05522996
96CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05223301
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05045140
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04737300
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03766503
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.03282428
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03143438
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02674410
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02416469
104P53_22387025_ChIP-Seq_ESCs_Mouse1.01621895
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.01376990
106E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00569856
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99061909
108JUN_21703547_ChIP-Seq_K562_Human0.98913650
109STAT3_18555785_Chip-Seq_ESCs_Mouse0.98879896
110TTF2_22483619_ChIP-Seq_HELA_Human0.98682444
111MYC_18555785_ChIP-Seq_MESCs_Mouse0.96812096
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96374417
113SMAD3_21741376_ChIP-Seq_EPCs_Human0.95926415
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95349381
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.95208223
116ZNF274_21170338_ChIP-Seq_K562_Hela0.94938452
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94604617
118P300_18555785_Chip-Seq_ESCs_Mouse0.94144271
119SOX2_19829295_ChIP-Seq_ESCs_Human0.94076970
120NANOG_19829295_ChIP-Seq_ESCs_Human0.94076970
121NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93384767
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93287162
123TFEB_21752829_ChIP-Seq_HELA_Human0.92822614
124HTT_18923047_ChIP-ChIP_STHdh_Human0.92721263
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92717474
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92428670
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92398361
128SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92112197
129SALL4_22934838_ChIP-ChIP_CD34+_Human0.91829244
130SOX17_20123909_ChIP-Seq_XEN_Mouse0.91300177
131CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90998218
132JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90206150
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.89671434
134PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89438827
135NOTCH1_21737748_ChIP-Seq_TLL_Human0.88917363
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.88482549
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87584922
138MYC_18940864_ChIP-ChIP_HL60_Human0.86849100
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86579065
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85415535
141SOX2_16153702_ChIP-ChIP_HESCs_Human0.84454087
142FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82724368
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.81829789
144TP53_22573176_ChIP-Seq_HFKS_Human0.78594168
145EGR1_23403033_ChIP-Seq_LIVER_Mouse0.77845743
146IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.73217297
147ELF5_23300383_ChIP-Seq_T47D_Human0.72973022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.63522614
2MP0010094_abnormal_chromosome_stability4.52594947
3MP0003806_abnormal_nucleotide_metabolis4.45916818
4MP0008058_abnormal_DNA_repair4.38521051
5MP0001529_abnormal_vocalization4.02158343
6MP0004957_abnormal_blastocyst_morpholog3.86527948
7MP0003693_abnormal_embryo_hatching3.55589166
8MP0003111_abnormal_nucleus_morphology3.52644121
9MP0003718_maternal_effect3.26404882
10MP0001905_abnormal_dopamine_level2.92817659
11MP0003077_abnormal_cell_cycle2.85382780
12MP0009379_abnormal_foot_pigmentation2.74757384
13MP0001188_hyperpigmentation2.73485783
14MP0008932_abnormal_embryonic_tissue2.69926040
15MP0008007_abnormal_cellular_replicative2.67396957
16MP0005409_darkened_coat_color2.46668880
17MP0003186_abnormal_redox_activity2.44410794
18MP0003786_premature_aging2.41620339
19MP0002736_abnormal_nociception_after2.34598885
20MP0006276_abnormal_autonomic_nervous2.32817054
21MP0008057_abnormal_DNA_replication2.24754395
22MP0003136_yellow_coat_color2.20661521
23MP0001968_abnormal_touch/_nociception2.20120761
24MP0002735_abnormal_chemical_nociception2.12875467
25MP0004142_abnormal_muscle_tone2.00036693
26MP0003941_abnormal_skin_development1.99783923
27MP0004147_increased_porphyrin_level1.93005634
28MP0002272_abnormal_nervous_system1.89749966
29MP0002837_dystrophic_cardiac_calcinosis1.85738666
30MP0000566_synostosis1.85543233
31MP0009745_abnormal_behavioral_response1.81364869
32MP0001986_abnormal_taste_sensitivity1.76507739
33MP0002876_abnormal_thyroid_physiology1.73962001
34MP0002734_abnormal_mechanical_nocicepti1.72847879
35MP0000358_abnormal_cell_content/1.71357013
36MP0000015_abnormal_ear_pigmentation1.69164793
37MP0002064_seizures1.68115296
38MP0000372_irregular_coat_pigmentation1.66738601
39MP0005171_absent_coat_pigmentation1.65603385
40MP0008877_abnormal_DNA_methylation1.65077474
41MP0003635_abnormal_synaptic_transmissio1.63964338
42MP0000920_abnormal_myelination1.63718301
43MP0002163_abnormal_gland_morphology1.63315372
44MP0004145_abnormal_muscle_electrophysio1.63213179
45MP0004270_analgesia1.62590647
46MP0008875_abnormal_xenobiotic_pharmacok1.60558317
47MP0005464_abnormal_platelet_physiology1.58309233
48MP0005645_abnormal_hypothalamus_physiol1.56285722
49MP0005646_abnormal_pituitary_gland1.56189211
50MP0002572_abnormal_emotion/affect_behav1.54575678
51MP0010386_abnormal_urinary_bladder1.54091737
52MP0002638_abnormal_pupillary_reflex1.52574525
53MP0006036_abnormal_mitochondrial_physio1.49055973
54MP0002102_abnormal_ear_morphology1.46307825
55MP0001486_abnormal_startle_reflex1.43754095
56MP0001970_abnormal_pain_threshold1.42140817
57MP0000778_abnormal_nervous_system1.41614732
58MP0005379_endocrine/exocrine_gland_phen1.39230669
59MP0002063_abnormal_learning/memory/cond1.37721412
60MP0003122_maternal_imprinting1.36489468
61MP0000350_abnormal_cell_proliferation1.34916218
62MP0001697_abnormal_embryo_size1.34107623
63MP0009046_muscle_twitch1.33863097
64MP0001485_abnormal_pinna_reflex1.33121882
65MP0002067_abnormal_sensory_capabilities1.31261133
66MP0005423_abnormal_somatic_nervous1.31058725
67MP0001440_abnormal_grooming_behavior1.30973219
68MP0002938_white_spotting1.30735301
69MP0005084_abnormal_gallbladder_morpholo1.29553292
70MP0004742_abnormal_vestibular_system1.28890458
71MP0002132_abnormal_respiratory_system1.27651974
72MP0003950_abnormal_plasma_membrane1.27485661
73MP0003195_calcinosis1.27094700
74MP0010307_abnormal_tumor_latency1.24033463
75MP0003787_abnormal_imprinting1.23405080
76MP0001929_abnormal_gametogenesis1.22971791
77MP0005386_behavior/neurological_phenoty1.22448903
78MP0004924_abnormal_behavior1.22448903
79MP0009697_abnormal_copulation1.21184732
80MP0001730_embryonic_growth_arrest1.19946080
81MP0002184_abnormal_innervation1.19489249
82MP0008995_early_reproductive_senescence1.19282078
83MP0002733_abnormal_thermal_nociception1.18452130
84MP0001963_abnormal_hearing_physiology1.16652363
85MP0001661_extended_life_span1.14981132
86MP0006035_abnormal_mitochondrial_morpho1.14810685
87MP0001984_abnormal_olfaction1.13847549
88MP0008872_abnormal_physiological_respon1.13705385
89MP0002160_abnormal_reproductive_system1.12259285
90MP0004859_abnormal_synaptic_plasticity1.11688211
91MP0000647_abnormal_sebaceous_gland1.10535333
92MP0005332_abnormal_amino_acid1.07849762
93MP0000313_abnormal_cell_death1.06173086
94MP0006072_abnormal_retinal_apoptosis1.04669607
95MP0005636_abnormal_mineral_homeostasis1.04526240
96MP0002019_abnormal_tumor_incidence1.03727641
97MP0001727_abnormal_embryo_implantation1.03374177
98MP0006292_abnormal_olfactory_placode1.02262789
99MP0005408_hypopigmentation1.01704833
100MP0004381_abnormal_hair_follicle1.01152264
101MP0008260_abnormal_autophagy0.99943937
102MP0003567_abnormal_fetal_cardiomyocyte0.99600670
103MP0001293_anophthalmia0.98886734
104MP0000631_abnormal_neuroendocrine_gland0.98177501
105MP0002095_abnormal_skin_pigmentation0.97570883
106MP0002090_abnormal_vision0.97431023
107MP0002557_abnormal_social/conspecific_i0.97217922
108MP0000653_abnormal_sex_gland0.96689567
109MP0001501_abnormal_sleep_pattern0.96488345
110MP0000026_abnormal_inner_ear0.96420414
111MP0008775_abnormal_heart_ventricle0.95145381
112MP0005551_abnormal_eye_electrophysiolog0.94970874
113MP0002210_abnormal_sex_determination0.94814606
114MP0003890_abnormal_embryonic-extraembry0.93804912
115MP0005389_reproductive_system_phenotype0.93056145
116MP0002080_prenatal_lethality0.92857781
117MP0006054_spinal_hemorrhage0.92649758
118MP0000751_myopathy0.92156720
119MP0002396_abnormal_hematopoietic_system0.92124900
120MP0001664_abnormal_digestion0.92046075
121MP0005395_other_phenotype0.91309824
122MP0005380_embryogenesis_phenotype0.91100348
123MP0001672_abnormal_embryogenesis/_devel0.91100348
124MP0001145_abnormal_male_reproductive0.89527970
125MP0000749_muscle_degeneration0.89185425
126MP0005075_abnormal_melanosome_morpholog0.88054597
127MP0003221_abnormal_cardiomyocyte_apopto0.87549769
128MP0001881_abnormal_mammary_gland0.87391873
129MP0008004_abnormal_stomach_pH0.86932078
130MP0004036_abnormal_muscle_relaxation0.86854479
131MP0002229_neurodegeneration0.86432035
132MP0004215_abnormal_myocardial_fiber0.84058575
133MP0005174_abnormal_tail_pigmentation0.83621481
134MP0000681_abnormal_thyroid_gland0.83250847
135MP0005266_abnormal_metabolism0.82726721
136MP0002877_abnormal_melanocyte_morpholog0.82200252
137MP0002752_abnormal_somatic_nervous0.82067411
138MP0003183_abnormal_peptide_metabolism0.81252865
139MP0002066_abnormal_motor_capabilities/c0.81098935
140MP0002084_abnormal_developmental_patter0.80717110
141MP0002751_abnormal_autonomic_nervous0.80016280
142MP0003121_genomic_imprinting0.79453688
143MP0002882_abnormal_neuron_morphology0.78039290
144MP0001502_abnormal_circadian_rhythm0.76004086
145MP0001119_abnormal_female_reproductive0.75920930
146MP0005253_abnormal_eye_physiology0.75031665
147MP0005410_abnormal_fertilization0.74988925
148MP0001873_stomach_inflammation0.74902432
149MP0003315_abnormal_perineum_morphology0.74622044
150MP0003656_abnormal_erythrocyte_physiolo0.74551782
151MP0003698_abnormal_male_reproductive0.73636466
152MP0003724_increased_susceptibility_to0.72748735
153MP0000427_abnormal_hair_cycle0.72140051
154MP0003984_embryonic_growth_retardation0.72095261
155MP0002822_catalepsy0.71371059
156MP0004134_abnormal_chest_morphology0.70552667
157MP0009250_abnormal_appendicular_skeleto0.70350962
158MP0002088_abnormal_embryonic_growth/wei0.69946861
159MP0000049_abnormal_middle_ear0.69003307
160MP0000955_abnormal_spinal_cord0.68908312
161MP0003938_abnormal_ear_development0.68545415
162MP0001764_abnormal_homeostasis0.68543532
163MP0002269_muscular_atrophy0.66676680
164MP0005187_abnormal_penis_morphology0.65784978
165MP0010352_gastrointestinal_tract_polyps0.65574418
166MP0008873_increased_physiological_sensi0.64451001
167MP0002085_abnormal_embryonic_tissue0.62206166
168MP0004084_abnormal_cardiac_muscle0.56232622
169MP0003937_abnormal_limbs/digits/tail_de0.56213781
170MP0002086_abnormal_extraembryonic_tissu0.56108145
171MP0001853_heart_inflammation0.56028105
172MP0005384_cellular_phenotype0.55592849

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.45333475
2Abnormal mitochondria in muscle tissue (HP:0008316)5.77655201
3Mitochondrial inheritance (HP:0001427)5.41639485
4Progressive macrocephaly (HP:0004481)5.37823100
5Acute encephalopathy (HP:0006846)4.95794248
6Hepatocellular necrosis (HP:0001404)4.68666607
7Increased CSF lactate (HP:0002490)4.59307479
8Abnormality of glycolysis (HP:0004366)4.21760007
9Increased serum pyruvate (HP:0003542)4.21760007
10Increased hepatocellular lipid droplets (HP:0006565)3.93516743
11Hepatic necrosis (HP:0002605)3.88906551
12Renal Fanconi syndrome (HP:0001994)3.70275046
133-Methylglutaconic aciduria (HP:0003535)3.59264867
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.51315063
15Abnormality of alanine metabolism (HP:0010916)3.51315063
16Hyperalaninemia (HP:0003348)3.51315063
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.47277683
18Optic disc pallor (HP:0000543)3.38486172
19Lipid accumulation in hepatocytes (HP:0006561)3.28683888
20Leukodystrophy (HP:0002415)3.23468292
21Exercise intolerance (HP:0003546)3.20239748
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19194208
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19194208
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.11537342
25Chromosomal breakage induced by crosslinking agents (HP:0003221)3.08098344
26Respiratory failure (HP:0002878)3.03594452
27Lactic acidosis (HP:0003128)3.02134563
28Cerebral edema (HP:0002181)3.01572078
29Abnormal hair whorl (HP:0010721)2.94245681
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93919350
31Chromsome breakage (HP:0040012)2.90966003
32Hypothermia (HP:0002045)2.90593594
33Medial flaring of the eyebrow (HP:0010747)2.88069904
34Meckel diverticulum (HP:0002245)2.85100507
35Neuroendocrine neoplasm (HP:0100634)2.83228362
36Abnormality of the ileum (HP:0001549)2.79423545
37Increased serum lactate (HP:0002151)2.78264350
38Abnormality of methionine metabolism (HP:0010901)2.74678671
39Parakeratosis (HP:0001036)2.64537014
40Increased intramyocellular lipid droplets (HP:0012240)2.64286556
41Focal motor seizures (HP:0011153)2.63892901
42Abnormality of chromosome stability (HP:0003220)2.59601438
43Pancreatic islet-cell hyperplasia (HP:0004510)2.55512970
44Pancreatic cysts (HP:0001737)2.53160802
45Exertional dyspnea (HP:0002875)2.52825646
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.51786065
47Cerebral hypomyelination (HP:0006808)2.51608194
48Abnormality of serum amino acid levels (HP:0003112)2.49545842
49Gait imbalance (HP:0002141)2.49020408
50Abnormality of the preputium (HP:0100587)2.46666839
51Nephrogenic diabetes insipidus (HP:0009806)2.42658974
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42101132
53Congenital primary aphakia (HP:0007707)2.39943309
54Type I transferrin isoform profile (HP:0003642)2.39843012
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.39227937
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39227937
57Respiratory difficulties (HP:0002880)2.36787664
58Myelodysplasia (HP:0002863)2.34941026
59Pheochromocytoma (HP:0002666)2.34507252
60Abnormality of the anterior horn cell (HP:0006802)2.31497387
61Degeneration of anterior horn cells (HP:0002398)2.31497387
62Abnormality of renal resorption (HP:0011038)2.30297175
63X-linked dominant inheritance (HP:0001423)2.27922134
64Abnormality of cells of the erythroid lineage (HP:0012130)2.27721207
65Small intestinal stenosis (HP:0012848)2.26572675
66Duodenal stenosis (HP:0100867)2.26572675
67Nephroblastoma (Wilms tumor) (HP:0002667)2.24243725
68Abnormal lung lobation (HP:0002101)2.24102157
69Retinal dysplasia (HP:0007973)2.23548298
70Pancytopenia (HP:0001876)2.22186411
71Hyperventilation (HP:0002883)2.20399234
72Hypoglycemic coma (HP:0001325)2.19575046
73Reduced antithrombin III activity (HP:0001976)2.15764588
74Atonic seizures (HP:0010819)2.15560843
75Congenital ichthyosiform erythroderma (HP:0007431)2.14573741
76Abnormal number of erythroid precursors (HP:0012131)2.10149903
77Lethargy (HP:0001254)2.09038472
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.08782204
79Microvesicular hepatic steatosis (HP:0001414)2.08620666
80Embryonal renal neoplasm (HP:0011794)2.08225985
81Abnormal ciliary motility (HP:0012262)2.07036864
82Pancreatic fibrosis (HP:0100732)2.06115552
83Progressive inability to walk (HP:0002505)2.05324800
84Birth length less than 3rd percentile (HP:0003561)2.05280221
85Dyschromatopsia (HP:0007641)2.04757830
86Vaginal atresia (HP:0000148)2.03332376
87Renal cortical cysts (HP:0000803)2.03183245
88Sloping forehead (HP:0000340)2.02998242
89Aplasia/hypoplasia of the uterus (HP:0008684)2.01896914
90Increased muscle lipid content (HP:0009058)2.00931197
91Exercise-induced muscle cramps (HP:0003710)2.00107732
92Genital tract atresia (HP:0001827)1.99727142
93Palpitations (HP:0001962)1.97070539
94Nemaline bodies (HP:0003798)1.96412504
95Generalized aminoaciduria (HP:0002909)1.95752357
96Poor suck (HP:0002033)1.95259139
97True hermaphroditism (HP:0010459)1.93390730
98Sensory axonal neuropathy (HP:0003390)1.93067761
99Hypoplasia of the uterus (HP:0000013)1.92714149
100Abnormal protein N-linked glycosylation (HP:0012347)1.91726575
101Abnormal protein glycosylation (HP:0012346)1.91726575
102Abnormal glycosylation (HP:0012345)1.91726575
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91726575
104Epileptic encephalopathy (HP:0200134)1.90680269
105Methylmalonic acidemia (HP:0002912)1.90162800
106Irregular epiphyses (HP:0010582)1.88115496
107Aplastic anemia (HP:0001915)1.87716270
108Paralysis (HP:0003470)1.86461938
109Abnormal respiratory epithelium morphology (HP:0012253)1.85100066
110Abnormal respiratory motile cilium morphology (HP:0005938)1.85100066
111Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.84862636
112Abnormal spermatogenesis (HP:0008669)1.83943902
113Neoplasm of the colon (HP:0100273)1.83566029
114Abnormality of the duodenum (HP:0002246)1.82865269
115Muscle fiber inclusion bodies (HP:0100299)1.82291082
116Hyperglycinemia (HP:0002154)1.82017509
117Inability to walk (HP:0002540)1.80638124
118CNS hypomyelination (HP:0003429)1.77095313
119Dynein arm defect of respiratory motile cilia (HP:0012255)1.76872324
120Absent/shortened dynein arms (HP:0200106)1.76872324
121CNS demyelination (HP:0007305)1.75489728
122Emotional lability (HP:0000712)1.74299080
123Volvulus (HP:0002580)1.73330235
124Esotropia (HP:0000565)1.71889704
125Patchy hypopigmentation of hair (HP:0011365)1.71562887
126Hyperglycinuria (HP:0003108)1.70720406
127Myokymia (HP:0002411)1.69075199
128Nausea (HP:0002018)1.69000588
129Type 2 muscle fiber atrophy (HP:0003554)1.68455784
130Methylmalonic aciduria (HP:0012120)1.67696709
131Muscle hypertrophy of the lower extremities (HP:0008968)1.67662548
132Neoplasm of the adrenal gland (HP:0100631)1.67423144
133Postnatal microcephaly (HP:0005484)1.66994028
134Hypoplastic left heart (HP:0004383)1.66945651
135Clubbing of toes (HP:0100760)1.65842592
136Respiratory insufficiency due to muscle weakness (HP:0002747)1.65539984
137Abnormal pupillary function (HP:0007686)1.65504920
138Colon cancer (HP:0003003)1.65243533
139Oral leukoplakia (HP:0002745)1.65169646
140Broad-based gait (HP:0002136)1.62115559
141Flat capital femoral epiphysis (HP:0003370)1.61796547
142Aplasia/Hypoplasia of the lens (HP:0008063)1.61674813
143Autoamputation (HP:0001218)1.61665722
144Molar tooth sign on MRI (HP:0002419)1.61141735
145Abnormality of midbrain morphology (HP:0002418)1.61141735
146Poor coordination (HP:0002370)1.60716288
147Abnormal respiratory motile cilium physiology (HP:0012261)1.59676098
148Delayed gross motor development (HP:0002194)1.57152177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.03942292
2TNIK3.33537212
3STK163.19103727
4MAP3K123.13919309
5NME12.78241424
6VRK22.59644812
7NEK12.57600626
8TTK2.43163040
9BMPR1B2.40003814
10MAP2K72.35313010
11CDK192.18740154
12STK392.11819225
13TRIM282.10380688
14ARAF2.08659081
15VRK12.05441126
16GRK72.04980030
17OXSR12.04817257
18BCR2.01637987
19MST41.98314353
20CDC71.97422271
21BCKDK1.93452870
22PLK41.82403965
23MKNK11.79152549
24SIK31.76470466
25LIMK11.73545354
26MAPK131.72130049
27MAPKAPK51.70957173
28BUB11.63611446
29NME21.62263675
30MYLK1.61456354
31STK31.49501497
32MAP4K21.46357320
33MKNK21.45547213
34SRPK11.41862667
35MUSK1.37457332
36DYRK21.34477999
37PLK21.32097561
38PLK11.29657380
39SCYL21.19318687
40EPHA41.16620091
41CCNB11.15574934
42ADRBK21.15536665
43CSNK1G31.13046967
44BRAF1.10199896
45CAMK2B1.09354074
46UHMK11.07674768
47BMPR21.06375600
48NEK61.06050458
49IRAK41.02879744
50EIF2AK31.02829939
51PIM21.02494359
52PBK1.02300790
53TAOK31.02170973
54PDK21.01068081
55CHEK20.99952740
56TLK10.96170306
57MARK10.94227636
58MAP3K40.93902560
59OBSCN0.90712717
60GRK10.89691573
61ATR0.89272613
62STK38L0.87945205
63ERBB40.83769851
64GRK50.82582227
65YES10.82544980
66ERBB30.82190220
67AURKB0.82133299
68NEK20.81211816
69CAMK2D0.80779432
70BRSK10.78139303
71STK240.78125815
72PKN10.77641589
73PIK3CG0.76403619
74CAMK2A0.76079745
75CLK10.72283887
76CDK80.71903462
77PRKCE0.71516067
78INSRR0.68912406
79PINK10.68724386
80TAF10.67500363
81CSNK1A1L0.65552997
82CSNK1G20.64520969
83PLK30.63656576
84NTRK30.63517626
85MINK10.63189292
86FGR0.63096777
87CAMK2G0.62666324
88MST1R0.62263535
89ADRBK10.62047542
90IRAK20.62035409
91TSSK60.61406831
92ZAK0.60019853
93ATM0.59648866
94ROCK20.59590817
95EIF2AK10.59526327
96CSNK1G10.59418150
97TXK0.58525615
98MAPKAPK30.57971807
99DYRK1A0.56931464
100CDK180.56914490
101ACVR1B0.55922208
102STK40.55533838
103PNCK0.54992051
104CDK140.54187352
105LATS10.53672140
106AKT30.53193880
107PRKCG0.52844318
108CSNK2A10.51411246
109RPS6KA50.50789822
110TEC0.48941397
111PIK3CA0.48532701
112CSNK2A20.48521458
113WEE10.48302212
114TGFBR10.47935091
115CHEK10.47559625
116CDK150.47173408
117TESK20.46951584
118RPS6KA40.46266788
119PRPF4B0.45899923
120NTRK20.45768486
121CDK11A0.45563937
122CDK30.45505261
123CAMKK20.45447805
124ALK0.45290818
125BRSK20.44746339
126CDK70.43976549
127NUAK10.43918362
128WNK40.43803137
129PHKG20.41575545
130PHKG10.41575545
131MAP3K60.41341274
132DAPK10.40792499
133AURKA0.40650151
134PRKACA0.39843128
135EIF2AK20.39159993
136FRK0.39021089
137MAP2K40.38983814
138WNK30.38960809
139KIT0.38848094
140ILK0.35743175
141MAP3K50.34188098
142FGFR10.33491062
143BMX0.32482274
144DYRK30.31669525
145FLT30.30728876
146STK100.28621833
147PASK0.27388656

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.19878052
2Parkinsons disease_Homo sapiens_hsa050124.38517044
3Protein export_Homo sapiens_hsa030603.86969230
4Proteasome_Homo sapiens_hsa030503.59210617
5Alzheimers disease_Homo sapiens_hsa050103.35139182
6Ribosome_Homo sapiens_hsa030103.18965454
7Huntingtons disease_Homo sapiens_hsa050163.10302091
8RNA polymerase_Homo sapiens_hsa030202.74187688
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.59238574
10One carbon pool by folate_Homo sapiens_hsa006702.43820878
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.39738896
12Collecting duct acid secretion_Homo sapiens_hsa049661.96462188
13Fatty acid elongation_Homo sapiens_hsa000621.91073788
14Cardiac muscle contraction_Homo sapiens_hsa042601.89751665
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86461126
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84025321
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75808684
18Vibrio cholerae infection_Homo sapiens_hsa051101.61822863
19Cell cycle_Homo sapiens_hsa041101.61366160
20Nicotine addiction_Homo sapiens_hsa050331.56374590
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.53314218
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44026032
23Ether lipid metabolism_Homo sapiens_hsa005651.44022808
24Pyrimidine metabolism_Homo sapiens_hsa002401.41602910
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38848575
26Basal transcription factors_Homo sapiens_hsa030221.33149747
27Selenocompound metabolism_Homo sapiens_hsa004501.24800049
28Serotonergic synapse_Homo sapiens_hsa047261.19862477
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16164223
30Sphingolipid metabolism_Homo sapiens_hsa006001.14830483
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14422694
32Spliceosome_Homo sapiens_hsa030401.10885457
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10349624
34Purine metabolism_Homo sapiens_hsa002301.08742547
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08041531
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07845749
37Steroid biosynthesis_Homo sapiens_hsa001001.07603325
38Synaptic vesicle cycle_Homo sapiens_hsa047211.04077444
39Carbon metabolism_Homo sapiens_hsa012001.01887987
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00135499
41Rheumatoid arthritis_Homo sapiens_hsa053230.98974385
42Nucleotide excision repair_Homo sapiens_hsa034200.98694520
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97496920
44Nitrogen metabolism_Homo sapiens_hsa009100.95682671
45Sulfur metabolism_Homo sapiens_hsa009200.93801767
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92560071
47Arachidonic acid metabolism_Homo sapiens_hsa005900.90604733
48Biosynthesis of amino acids_Homo sapiens_hsa012300.89878732
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88902646
50Peroxisome_Homo sapiens_hsa041460.88374667
51Phototransduction_Homo sapiens_hsa047440.87519152
52Butanoate metabolism_Homo sapiens_hsa006500.86608263
53Homologous recombination_Homo sapiens_hsa034400.85212247
54Phagosome_Homo sapiens_hsa041450.85130958
55Mismatch repair_Homo sapiens_hsa034300.84857860
56Taste transduction_Homo sapiens_hsa047420.84101376
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83487481
58RNA degradation_Homo sapiens_hsa030180.82894796
59Non-homologous end-joining_Homo sapiens_hsa034500.81268851
60Regulation of autophagy_Homo sapiens_hsa041400.80881909
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79842686
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79154947
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78715215
64Morphine addiction_Homo sapiens_hsa050320.75912679
65Autoimmune thyroid disease_Homo sapiens_hsa053200.73888066
66Metabolic pathways_Homo sapiens_hsa011000.73657197
67GABAergic synapse_Homo sapiens_hsa047270.71477581
68p53 signaling pathway_Homo sapiens_hsa041150.71070891
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69685608
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69567785
71DNA replication_Homo sapiens_hsa030300.69124613
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68727421
73Linoleic acid metabolism_Homo sapiens_hsa005910.68391065
74Amphetamine addiction_Homo sapiens_hsa050310.68286237
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66561042
76Pentose phosphate pathway_Homo sapiens_hsa000300.66551334
77mRNA surveillance pathway_Homo sapiens_hsa030150.63104066
78Dopaminergic synapse_Homo sapiens_hsa047280.63048245
79Fatty acid metabolism_Homo sapiens_hsa012120.60474398
80Glutamatergic synapse_Homo sapiens_hsa047240.59025162
81Base excision repair_Homo sapiens_hsa034100.57149171
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56804860
83Long-term depression_Homo sapiens_hsa047300.55457046
84Circadian entrainment_Homo sapiens_hsa047130.53608217
85Olfactory transduction_Homo sapiens_hsa047400.51861465
86N-Glycan biosynthesis_Homo sapiens_hsa005100.50925279
87Other glycan degradation_Homo sapiens_hsa005110.50891104
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50598914
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50188775
90Alcoholism_Homo sapiens_hsa050340.47890420
91Calcium signaling pathway_Homo sapiens_hsa040200.46781260
92Axon guidance_Homo sapiens_hsa043600.44487580
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43966900
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43526828
95Fatty acid degradation_Homo sapiens_hsa000710.42092410
96Cocaine addiction_Homo sapiens_hsa050300.41906391
97Tryptophan metabolism_Homo sapiens_hsa003800.41067467
98Glutathione metabolism_Homo sapiens_hsa004800.40245062
99Chemical carcinogenesis_Homo sapiens_hsa052040.40228849
100Systemic lupus erythematosus_Homo sapiens_hsa053220.40050411
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.39928313
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39784564
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39587704
104Allograft rejection_Homo sapiens_hsa053300.39040727
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38370487
106Pyruvate metabolism_Homo sapiens_hsa006200.37278299
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37228810
108Vitamin B6 metabolism_Homo sapiens_hsa007500.36887450
109Propanoate metabolism_Homo sapiens_hsa006400.35693497
110Asthma_Homo sapiens_hsa053100.35473041
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.35263923
112Epstein-Barr virus infection_Homo sapiens_hsa051690.33353667
113Cholinergic synapse_Homo sapiens_hsa047250.32878274
114Primary immunodeficiency_Homo sapiens_hsa053400.32155957
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31622695
116Fanconi anemia pathway_Homo sapiens_hsa034600.31444735
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30483646
118Renin secretion_Homo sapiens_hsa049240.30200786
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29370438
120Long-term potentiation_Homo sapiens_hsa047200.27850644
121RNA transport_Homo sapiens_hsa030130.27811242
122Caffeine metabolism_Homo sapiens_hsa002320.26048591
123Sulfur relay system_Homo sapiens_hsa041220.25610633
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.25518936
125beta-Alanine metabolism_Homo sapiens_hsa004100.24765463
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.24113431
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23505846
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22952485
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.21462933
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21298320
131Folate biosynthesis_Homo sapiens_hsa007900.20672909
132Hematopoietic cell lineage_Homo sapiens_hsa046400.19817508
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19799153
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18658511
135Insulin secretion_Homo sapiens_hsa049110.18267512
136Histidine metabolism_Homo sapiens_hsa003400.17086436
137Starch and sucrose metabolism_Homo sapiens_hsa005000.16608059
138Graft-versus-host disease_Homo sapiens_hsa053320.16494665
139Arginine and proline metabolism_Homo sapiens_hsa003300.16286304
140Circadian rhythm_Homo sapiens_hsa047100.15580934
141Viral carcinogenesis_Homo sapiens_hsa052030.14221856
142Salivary secretion_Homo sapiens_hsa049700.13744404
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13000979
144Oocyte meiosis_Homo sapiens_hsa041140.11139562
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10872488

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