FOS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO5.97400328
2regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)5.97400328
3radial glial cell differentiation (GO:0060019)5.78035007
4regulation of cardioblast proliferation (GO:0003264)5.68981620
5regulation of secondary heart field cardioblast proliferation (GO:0003266)5.68981620
6regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.17996935
7positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.17996935
8definitive hemopoiesis (GO:0060216)5.04496312
9tolerance induction (GO:0002507)5.04318904
10regulation of cell proliferation involved in kidney development (GO:1901722)5.01119663
11positive regulation of astrocyte differentiation (GO:0048711)4.88776778
12positive regulation of mRNA catabolic process (GO:0061014)4.81990131
13response to muramyl dipeptide (GO:0032495)4.81207305
14endoderm formation (GO:0001706)4.44972810
15regulation of germinal center formation (GO:0002634)4.41763911
16cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.40214277
17regulation of timing of cell differentiation (GO:0048505)4.34743570
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33639923
19negative regulation of cell killing (GO:0031342)4.33639923
20regulation of mRNA catabolic process (GO:0061013)4.31835094
21neuron fate determination (GO:0048664)4.28547794
22RNA destabilization (GO:0050779)4.19261972
23thrombin receptor signaling pathway (GO:0070493)4.05582275
24interleukin-1-mediated signaling pathway (GO:0070498)4.04987174
25negative regulation of interleukin-1 beta production (GO:0032691)4.02326929
26regulation of gamma-delta T cell differentiation (GO:0045586)3.97953973
27platelet dense granule organization (GO:0060155)3.96971610
28positive regulation of glomerulus development (GO:0090193)3.89654180
29regulation of B cell receptor signaling pathway (GO:0050855)3.75250118
30endothelial cell chemotaxis (GO:0035767)3.74141448
31negative regulation of bone resorption (GO:0045779)3.74012555
32regulation of gamma-delta T cell activation (GO:0046643)3.72078630
33regulation of development, heterochronic (GO:0040034)3.69124872
34negative regulation of epidermal cell differentiation (GO:0045605)3.63697125
35regulation of memory T cell differentiation (GO:0043380)3.62165846
36negative regulation of interleukin-1 production (GO:0032692)3.61803172
37cell wall macromolecule catabolic process (GO:0016998)3.61752569
38negative thymic T cell selection (GO:0045060)3.59831944
39cellular response to interleukin-15 (GO:0071350)3.58635203
40cell proliferation involved in kidney development (GO:0072111)3.57137765
41negative T cell selection (GO:0043383)3.55243034
42mitotic cell cycle arrest (GO:0071850)3.54484468
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.53196087
44cellular response to antibiotic (GO:0071236)3.51495811
45T-helper cell differentiation (GO:0042093)3.45047026
46CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.45047026
47microglial cell activation (GO:0001774)3.43371156
48cell morphogenesis involved in neuron differentiation (GO:0048667)3.39693987
49neuronal stem cell maintenance (GO:0097150)3.39577706
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.36588064
51negative regulation of protein autophosphorylation (GO:0031953)3.33355201
52regulation of T cell mediated cytotoxicity (GO:0001914)3.32390628
53positive regulation of gamma-delta T cell activation (GO:0046645)3.28033110
54negative regulation of erythrocyte differentiation (GO:0045647)3.27758269
55positive regulation of p38MAPK cascade (GO:1900745)3.26891723
56peptidyl-tyrosine autophosphorylation (GO:0038083)3.24931368
57positive regulation of T cell differentiation in thymus (GO:0033089)3.24444590
58neutrophil activation (GO:0042119)3.24080830
59positive regulation of mRNA 3-end processing (GO:0031442)3.19442869
60positive regulation of T cell mediated cytotoxicity (GO:0001916)3.17898992
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16953593
62cellular response to gonadotropin stimulus (GO:0071371)3.14330348
63positive regulation of Notch signaling pathway (GO:0045747)3.13900131
64regulation of cellular extravasation (GO:0002691)3.13471104
65response to laminar fluid shear stress (GO:0034616)3.13361185
66positive regulation of T-helper 1 type immune response (GO:0002827)3.11768431
67cell wall macromolecule metabolic process (GO:0044036)3.10439277
68positive thymic T cell selection (GO:0045059)3.08606163
69T cell differentiation involved in immune response (GO:0002292)3.07561047
70alpha-beta T cell differentiation involved in immune response (GO:0002293)3.07561047
71alpha-beta T cell activation involved in immune response (GO:0002287)3.07561047
72oligodendrocyte differentiation (GO:0048709)3.06909856
73response to follicle-stimulating hormone (GO:0032354)3.06729775
74nephron tubule morphogenesis (GO:0072078)3.06706826
75nephron epithelium morphogenesis (GO:0072088)3.06706826
76interferon-gamma production (GO:0032609)3.05354987
77regulation of glomerulus development (GO:0090192)3.05147675
78germ cell migration (GO:0008354)3.04890953
79negative regulation of glial cell proliferation (GO:0060253)3.03878466
80endocardial cushion morphogenesis (GO:0003203)3.03150632
81negative regulation of innate immune response (GO:0045824)3.02356666
82positive regulation of metanephros development (GO:0072216)3.02310617
83protein K11-linked deubiquitination (GO:0035871)2.98952629
84positive regulation of defense response to virus by host (GO:0002230)2.98004791
85regulation of monocyte differentiation (GO:0045655)2.95639222
86mast cell activation (GO:0045576)2.95304903
87response to interleukin-15 (GO:0070672)2.95065520
88lymph vessel development (GO:0001945)2.93188846
89regulation of regulatory T cell differentiation (GO:0045589)2.92187150
90negative regulation of glycoprotein biosynthetic process (GO:0010561)2.92167873
91negative regulation of bone remodeling (GO:0046851)2.91722517
92negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.91696790
93negative regulation of T cell mediated immunity (GO:0002710)2.86980630
94antigen processing and presentation of endogenous antigen (GO:0019883)2.85436129
95G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.84753222
96ventricular septum development (GO:0003281)2.83345019
97dentate gyrus development (GO:0021542)2.81985336
98regulation of T-helper 1 type immune response (GO:0002825)2.81611412
99regulation of p38MAPK cascade (GO:1900744)2.80998324
100cell-cell signaling involved in cell fate commitment (GO:0045168)2.80239854
101regulation of defense response to virus by host (GO:0050691)2.79866054
102ventricular septum morphogenesis (GO:0060412)2.79409903
103negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79160418
104negative regulation of translation, ncRNA-mediated (GO:0040033)2.79160418
105regulation of translation, ncRNA-mediated (GO:0045974)2.79160418
106negative regulation of interleukin-6 production (GO:0032715)2.77645970
107negative regulation of oligodendrocyte differentiation (GO:0048715)2.76701790
108regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.76130440
109cellular response to exogenous dsRNA (GO:0071360)2.76115882
110positive regulation of alpha-beta T cell proliferation (GO:0046641)2.74917634
111negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.74341110
112mature B cell differentiation involved in immune response (GO:0002313)2.74109049
113neutrophil activation involved in immune response (GO:0002283)2.73675917
114negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.73508318
115regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72622633
116negative regulation of transcription by competitive promoter binding (GO:0010944)2.70476933
117positive regulation of mRNA metabolic process (GO:1903313)2.70370847
118regulation of alpha-beta T cell proliferation (GO:0046640)2.69148324
119neural crest cell development (GO:0014032)2.68456141
120granulocyte activation (GO:0036230)2.68064062
121* response to progesterone (GO:0032570)2.67416265
122alpha-beta T cell differentiation (GO:0046632)2.67216809
123nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.66481427
124positive regulation of sterol transport (GO:0032373)2.66185906
125positive regulation of cholesterol transport (GO:0032376)2.66185906
126negative regulation of lymphocyte mediated immunity (GO:0002707)2.66156089
127response to nitrosative stress (GO:0051409)2.65865307
128relaxation of smooth muscle (GO:0044557)2.65780363
129phospholipid scrambling (GO:0017121)2.63353665
130* skeletal muscle cell differentiation (GO:0035914)2.62267898
131fucose catabolic process (GO:0019317)2.62263566
132L-fucose metabolic process (GO:0042354)2.62263566
133L-fucose catabolic process (GO:0042355)2.62263566
134regulation of mRNA 3-end processing (GO:0031440)2.61896212
135telencephalon development (GO:0021537)2.61577462
136antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61335853
137CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.61292337
138dendritic cell chemotaxis (GO:0002407)2.61136740
139cranial nerve development (GO:0021545)2.61132582
140negative regulation of meiotic cell cycle (GO:0051447)2.60995776
141regulation of T cell receptor signaling pathway (GO:0050856)2.60617658
142negative regulation of epidermis development (GO:0045683)2.58110730
143activated T cell proliferation (GO:0050798)2.57911659
144regulation of antigen processing and presentation (GO:0002577)2.57814277
145atrioventricular valve morphogenesis (GO:0003181)2.57116481
146positive T cell selection (GO:0043368)2.56839154
147gland morphogenesis (GO:0022612)2.55244905
148regulation of mast cell activation (GO:0033003)2.55037305
149mast cell degranulation (GO:0043303)2.54977924
150mast cell activation involved in immune response (GO:0002279)2.54977924
151cellular response to thyroid hormone stimulus (GO:0097067)2.54106190
152negative regulation of smooth muscle contraction (GO:0045986)2.53233870
153positive regulation of glial cell differentiation (GO:0045687)2.52026229
154regulation of T cell mediated immunity (GO:0002709)2.51614059
155positive regulation of antigen processing and presentation (GO:0002579)2.50860702
156negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50617575
157renal tubule morphogenesis (GO:0061333)2.50187530
158Notch receptor processing (GO:0007220)2.49937394
159lymphoid progenitor cell differentiation (GO:0002320)2.49922071
160positive regulation of mRNA processing (GO:0050685)2.49898015
161positive regulation of T cell mediated immunity (GO:0002711)2.48916844
162alpha-beta T cell activation (GO:0046631)2.47687315
163T cell selection (GO:0045058)2.46351653
164purinergic nucleotide receptor signaling pathway (GO:0035590)2.45576529
165positive regulation of granulocyte differentiation (GO:0030854)2.44990685
166viral protein processing (GO:0019082)2.44339332
167inactivation of MAPK activity (GO:0000188)2.43850541
168negative regulation of tissue remodeling (GO:0034104)2.43785083
169adaptation of signaling pathway (GO:0023058)2.43075643
170labyrinthine layer blood vessel development (GO:0060716)2.43058870
171T cell differentiation (GO:0030217)2.42578964
172peptidyl-threonine dephosphorylation (GO:0035970)2.42100082
173angiogenesis involved in wound healing (GO:0060055)2.41766897
174blood vessel maturation (GO:0001955)2.41678111
175DNA deamination (GO:0045006)2.41450524
176positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.41340318
177positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.41220649
178mesenchymal cell development (GO:0014031)2.40167340
179cell fate determination (GO:0001709)2.40025528
180cellular response to toxic substance (GO:0097237)2.39367898
181negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.37190101
182negative regulation of cAMP-mediated signaling (GO:0043951)2.37096283
183facial nerve structural organization (GO:0021612)2.36473185
184heart valve morphogenesis (GO:0003179)2.34902541
185negative regulation of gluconeogenesis (GO:0045721)2.34558413
186regulation of cytokine production involved in inflammatory response (GO:1900015)2.34423213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.22340991
2NOTCH1_21737748_ChIP-Seq_TLL_Human3.35554554
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.35552852
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.31436283
5SCL_19346495_ChIP-Seq_HPC-7_Human3.21666700
6* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.20939828
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.00355813
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93460860
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.59326199
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52814947
11FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.34929953
12* GATA2_21666600_ChIP-Seq_HMVEC_Human2.26941117
13MYB_26560356_Chip-Seq_TH2_Human2.20468734
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17224329
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.13526082
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.12479215
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.03818136
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.02639193
19* RUNX_20019798_ChIP-Seq_JUKART_Human1.96406388
20* CLOCK_20551151_ChIP-Seq_293T_Human1.95102131
21VDR_22108803_ChIP-Seq_LS180_Human1.91592579
22GATA3_26560356_Chip-Seq_TH2_Human1.89709641
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79286329
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73237532
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69450127
26* GATA3_27048872_Chip-Seq_THYMUS_Human1.67677928
27ZNF274_21170338_ChIP-Seq_K562_Hela1.66909623
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66649923
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61889644
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61662930
31CDX2_20551321_ChIP-Seq_CACO-2_Human1.58393980
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.56761340
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56541296
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55223021
35* IRF8_27001747_Chip-Seq_BMDM_Mouse1.52885836
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51937157
37* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50721698
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.42176632
39* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39895403
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38732685
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37952164
42MYB_26560356_Chip-Seq_TH1_Human1.36857283
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36666018
44TAF15_26573619_Chip-Seq_HEK293_Human1.36495893
45CJUN_26792858_Chip-Seq_BT549_Human1.34740458
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34336122
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33885908
48* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33764627
49* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33764627
50* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33764627
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.32874639
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32502455
53* GATA1_19941826_ChIP-Seq_K562_Human1.31314258
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31243074
55SOX2_20726797_ChIP-Seq_SW620_Human1.30604746
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27549968
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27524965
58* AHR_22903824_ChIP-Seq_MCF-7_Human1.25881017
59IGF1R_20145208_ChIP-Seq_DFB_Human1.24974689
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24882270
61* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23998525
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23213582
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20471783
64ER_23166858_ChIP-Seq_MCF-7_Human1.19489427
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18895622
66GATA1_22025678_ChIP-Seq_K562_Human1.18637633
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17781906
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17764988
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17764988
70* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17396537
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17185547
72* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16575907
73* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16276737
74* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16227986
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15692532
76* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15376937
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14123536
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13207435
79BCAT_22108803_ChIP-Seq_LS180_Human1.13117799
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12825719
81UTX_26944678_Chip-Seq_JUKART_Human1.12222955
82* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11688045
83* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10888484
84EZH2_27304074_Chip-Seq_ESCs_Mouse1.10829210
85AR_21572438_ChIP-Seq_LNCaP_Human1.10410199
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10118982
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09826741
88MAF_26560356_Chip-Seq_TH1_Human1.09185600
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08825891
90* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08704520
91* RUNX1_22412390_ChIP-Seq_EML_Mouse1.07828071
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07393879
93* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05828997
94TP53_18474530_ChIP-ChIP_U2OS_Human1.05792925
95* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05767976
96JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05296266
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04669756
98* EZH2_27294783_Chip-Seq_ESCs_Mouse1.04362960
99IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04172121
100* TP53_20018659_ChIP-ChIP_R1E_Mouse1.03289705
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.03258973
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.01701193
103* RING1B_27294783_Chip-Seq_NPCs_Mouse1.01290432
104GBX2_23144817_ChIP-Seq_PC3_Human1.01219068
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00875716
106* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99451942
107AR_20517297_ChIP-Seq_VCAP_Human0.99156088
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98756005
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98178669
110* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98116066
111* GATA2_19941826_ChIP-Seq_K562_Human0.97717398
112* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97681490
113PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96672529
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96268728
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95942915
116* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95748342
117POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95697390
118MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94856743
119IRF1_19129219_ChIP-ChIP_H3396_Human0.94812974
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94411924
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94403846
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94000498
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94000498
124GATA3_21878914_ChIP-Seq_MCF-7_Human0.92984834
125DROSHA_22980978_ChIP-Seq_HELA_Human0.91867821
126* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91852231
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91655761
128* SMRT_27268052_Chip-Seq_Bcells_Human0.91497078
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91156121
130VDR_24763502_ChIP-Seq_THP-1_Human0.91029898
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90645157
132TP53_22573176_ChIP-Seq_HFKS_Human0.90386517
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.90293556
134* SPI1_23547873_ChIP-Seq_NB4_Human0.90211239
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.89190579
136* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89169953
137SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88934461
138NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88236785
139* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87005167
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86710546
141RXR_22108803_ChIP-Seq_LS180_Human0.86332634
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86136223
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86136223
144VDR_24787735_ChIP-Seq_THP-1_Human0.86111872
145DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85920594
146SMAD_19615063_ChIP-ChIP_OVARY_Human0.85915651
147GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85519640
148VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85209202
149STAT1_20625510_ChIP-Seq_HELA_Human0.84983365
150RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84945330
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84923233
152* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84482093
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84396586
154FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84367123
155* RUNX1_27514584_Chip-Seq_MCF-7_Human0.84199236
156EZH2_27294783_Chip-Seq_NPCs_Mouse0.83450352
157FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83120122
158ZNF263_19887448_ChIP-Seq_K562_Human0.82763987
159* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82629875
160ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82107566
161AR_25329375_ChIP-Seq_VCAP_Human0.81455375
162FOXA1_25329375_ChIP-Seq_VCAP_Human0.81362973
163FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81362973
164NFE2_27457419_Chip-Seq_LIVER_Mouse0.80420295
165P300_19829295_ChIP-Seq_ESCs_Human0.80027014
166* FLI1_21867929_ChIP-Seq_TH2_Mouse0.79599101
167CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78275341
168JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78218049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.58810420
2MP0010368_abnormal_lymphatic_system4.20166971
3MP0002254_reproductive_system_inflammat3.90040999
4MP0003828_pulmonary_edema3.57859996
5MP0005646_abnormal_pituitary_gland3.06553115
6MP0005084_abnormal_gallbladder_morpholo2.83981884
7MP0001879_abnormal_lymphatic_vessel2.82992951
8MP0002009_preneoplasia2.73795351
9MP0001851_eye_inflammation2.69080398
10MP0005671_abnormal_response_to2.69030811
11MP0002877_abnormal_melanocyte_morpholog2.28615255
12MP0006292_abnormal_olfactory_placode2.25112160
13MP0002928_abnormal_bile_duct2.22121465
14MP0009278_abnormal_bone_marrow2.00810857
15MP0000685_abnormal_immune_system1.97880953
16MP0003943_abnormal_hepatobiliary_system1.94374025
17MP0009379_abnormal_foot_pigmentation1.93392248
18MP0003183_abnormal_peptide_metabolism1.86779668
19MP0001346_abnormal_lacrimal_gland1.82540914
20MP0009785_altered_susceptibility_to1.81643008
21MP0002006_tumorigenesis1.75618797
22MP0001853_heart_inflammation1.74207504
23* MP0001501_abnormal_sleep_pattern1.70052364
24MP0002876_abnormal_thyroid_physiology1.67987405
25MP0003136_yellow_coat_color1.62884169
26MP0002277_abnormal_respiratory_mucosa1.59744216
27* MP0005025_abnormal_response_to1.59566932
28MP0004883_abnormal_blood_vessel1.58799398
29MP0002933_joint_inflammation1.57005352
30MP0005409_darkened_coat_color1.56563405
31MP0003690_abnormal_glial_cell1.55285087
32MP0004808_abnormal_hematopoietic_stem1.53135538
33MP0000465_gastrointestinal_hemorrhage1.50029874
34MP0004147_increased_porphyrin_level1.48265690
35MP0001533_abnormal_skeleton_physiology1.47871876
36MP0002938_white_spotting1.44427605
37MP0000678_abnormal_parathyroid_gland1.43813508
38MP0003075_altered_response_to1.43716578
39MP0003279_aneurysm1.40723279
40MP0001845_abnormal_inflammatory_respons1.39488896
41MP0009764_decreased_sensitivity_to1.38571620
42MP0001188_hyperpigmentation1.33682495
43MP0005167_abnormal_blood-brain_barrier1.32551667
44MP0004885_abnormal_endolymph1.32451224
45MP0005670_abnormal_white_adipose1.31654381
46MP0005164_abnormal_response_to1.30924134
47MP0002405_respiratory_system_inflammati1.29168954
48MP0003656_abnormal_erythrocyte_physiolo1.29081714
49MP0000613_abnormal_salivary_gland1.27315156
50* MP0000716_abnormal_immune_system1.26955886
51MP0000762_abnormal_tongue_morphology1.25825420
52MP0001919_abnormal_reproductive_system1.25420509
53MP0003866_abnormal_defecation1.25081430
54MP0004381_abnormal_hair_follicle1.22349969
55MP0002148_abnormal_hypersensitivity_rea1.20010383
56MP0004272_abnormal_basement_membrane1.19763499
57* MP0002398_abnormal_bone_marrow1.19431736
58MP0005000_abnormal_immune_tolerance1.19333562
59* MP0002419_abnormal_innate_immunity1.18878865
60MP0004947_skin_inflammation1.18573433
61* MP0000689_abnormal_spleen_morphology1.17912329
62MP0002396_abnormal_hematopoietic_system1.17792548
63MP0003011_delayed_dark_adaptation1.17387484
64MP0002132_abnormal_respiratory_system1.15637823
65MP0000467_abnormal_esophagus_morphology1.14134196
66MP0001986_abnormal_taste_sensitivity1.13858426
67MP0002060_abnormal_skin_morphology1.12934475
68* MP0002722_abnormal_immune_system1.11555235
69MP0005390_skeleton_phenotype1.11308360
70MP0008875_abnormal_xenobiotic_pharmacok1.11274209
71MP0001542_abnormal_bone_strength1.10697277
72MP0000383_abnormal_hair_follicle1.10419316
73MP0008995_early_reproductive_senescence1.09806834
74MP0008007_abnormal_cellular_replicative1.09502715
75MP0003195_calcinosis1.08524663
76MP0005165_increased_susceptibility_to1.06133960
77MP0006082_CNS_inflammation1.06121525
78MP0001270_distended_abdomen1.04206262
79MP0005023_abnormal_wound_healing1.03977934
80MP0000631_abnormal_neuroendocrine_gland1.03471165
81MP0008469_abnormal_protein_level1.01757740
82MP0001835_abnormal_antigen_presentation1.01348003
83MP0001790_abnormal_immune_system1.01139281
84MP0005387_immune_system_phenotype1.01139281
85MP0000249_abnormal_blood_vessel1.00038413
86MP0001873_stomach_inflammation0.96596198
87MP0001765_abnormal_ion_homeostasis0.95557533
88MP0001502_abnormal_circadian_rhythm0.94818173
89* MP0002452_abnormal_antigen_presenting0.92623814
90* MP0002429_abnormal_blood_cell0.91895489
91MP0008872_abnormal_physiological_respon0.91681147
92MP0003763_abnormal_thymus_physiology0.90872536
93* MP0000703_abnormal_thymus_morphology0.90010401
94MP0008877_abnormal_DNA_methylation0.89739824
95* MP0002723_abnormal_immune_serum0.88622614
96MP0002295_abnormal_pulmonary_circulatio0.87689769
97MP0008004_abnormal_stomach_pH0.87065982
98MP0002166_altered_tumor_susceptibility0.86705009
99MP0003436_decreased_susceptibility_to0.86581158
100MP0005397_hematopoietic_system_phenotyp0.85744895
101MP0001545_abnormal_hematopoietic_system0.85744895
102MP0000230_abnormal_systemic_arterial0.85740631
103MP0002138_abnormal_hepatobiliary_system0.85669833
104MP0008961_abnormal_basal_metabolism0.85338575
105MP0005174_abnormal_tail_pigmentation0.84194077
106MP0005171_absent_coat_pigmentation0.84089266
107MP0001958_emphysema0.83718877
108MP0002133_abnormal_respiratory_system0.83624997
109MP0005388_respiratory_system_phenotype0.83624997
110MP0001944_abnormal_pancreas_morphology0.83272866
111MP0005464_abnormal_platelet_physiology0.83114653
112MP0002998_abnormal_bone_remodeling0.81720919
113MP0000767_abnormal_smooth_muscle0.81654419
114MP0001800_abnormal_humoral_immune0.81103776
115* MP0005551_abnormal_eye_electrophysiolog0.80694674
116MP0010386_abnormal_urinary_bladder0.80572980
117MP0005310_abnormal_salivary_gland0.79959490
118MP0001191_abnormal_skin_condition0.79639463
119MP0003303_peritoneal_inflammation0.79620609
120MP0005075_abnormal_melanosome_morpholog0.78598857
121MP0002098_abnormal_vibrissa_morphology0.78543835
122MP0005379_endocrine/exocrine_gland_phen0.78338223
123MP0003453_abnormal_keratinocyte_physiol0.78022587
124* MP0002420_abnormal_adaptive_immunity0.77934116
125MP0003252_abnormal_bile_duct0.77440925
126MP0005508_abnormal_skeleton_morphology0.77180468
127MP0010329_abnormal_lipoprotein_level0.76992599
128MP0000013_abnormal_adipose_tissue0.76686024
129MP0005389_reproductive_system_phenotype0.76424920
130MP0001968_abnormal_touch/_nociception0.75063658
131MP0003638_abnormal_response/metabolism_0.74489864
132MP0000049_abnormal_middle_ear0.74068753
133* MP0001819_abnormal_immune_cell0.73951117
134MP0002102_abnormal_ear_morphology0.73838540
135MP0005595_abnormal_vascular_smooth0.73395221
136MP0010678_abnormal_skin_adnexa0.73180685
137MP0001905_abnormal_dopamine_level0.73180493
138MP0010155_abnormal_intestine_physiology0.72656800
139MP0005166_decreased_susceptibility_to0.71251221
140MP0002653_abnormal_ependyma_morphology0.71235782
141MP0004484_altered_response_of0.67867889
142MP0005377_hearing/vestibular/ear_phenot0.67367242
143MP0003878_abnormal_ear_physiology0.67367242
144MP0002136_abnormal_kidney_physiology0.65828762
145MP0009763_increased_sensitivity_to0.65748236
146* MP0003795_abnormal_bone_structure0.64438883

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.60317546
2Stomatitis (HP:0010280)4.43377598
3Myositis (HP:0100614)4.29093738
4Prostate neoplasm (HP:0100787)4.27582965
5Hypothermia (HP:0002045)4.18231383
6IgG deficiency (HP:0004315)4.05470667
7White forelock (HP:0002211)4.02360776
8Patchy hypopigmentation of hair (HP:0011365)3.85548524
9Optic neuritis (HP:0100653)3.79955021
10Retrobulbar optic neuritis (HP:0100654)3.79955021
11Stomach cancer (HP:0012126)3.68241134
12Split foot (HP:0001839)3.50229923
13Orchitis (HP:0100796)3.48829834
14Severe combined immunodeficiency (HP:0004430)3.13591475
15Partial duplication of thumb phalanx (HP:0009944)3.12423132
16Hematochezia (HP:0002573)3.06966385
17Median cleft lip (HP:0000161)3.03890439
18Pulmonary infiltrates (HP:0002113)3.03357665
19Congenital stationary night blindness (HP:0007642)3.01685985
20Keratoconjunctivitis (HP:0001096)2.96238114
21Abnormality of eosinophils (HP:0001879)2.94755796
22True hermaphroditism (HP:0010459)2.91685377
23Submucous cleft hard palate (HP:0000176)2.85350323
24Lip pit (HP:0100267)2.84804821
25Chronic otitis media (HP:0000389)2.80612671
26Pustule (HP:0200039)2.79828128
27Recurrent fungal infections (HP:0002841)2.78885274
28Abnormality of T cell physiology (HP:0011840)2.77138737
29Abnormality of T cells (HP:0002843)2.75675687
30Panhypogammaglobulinemia (HP:0003139)2.71614864
31Prolonged bleeding time (HP:0003010)2.71494471
32Partial duplication of the phalanx of hand (HP:0009999)2.70422973
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.69512271
34Leukocytosis (HP:0001974)2.63746935
35Stridor (HP:0010307)2.63633525
36Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62246254
37Abolished electroretinogram (ERG) (HP:0000550)2.62242953
38Vacuolated lymphocytes (HP:0001922)2.61122462
39Hemoptysis (HP:0002105)2.60326238
40Chronic mucocutaneous candidiasis (HP:0002728)2.60192846
41Recurrent cutaneous fungal infections (HP:0011370)2.60192846
42Clumsiness (HP:0002312)2.59608556
43Abnormality of the renal cortex (HP:0011035)2.56978392
44Congenital sensorineural hearing impairment (HP:0008527)2.53415255
45Pancreatic cysts (HP:0001737)2.53237362
46Abnormal ciliary motility (HP:0012262)2.52871798
47Abnormality of T cell number (HP:0011839)2.50896567
48Keratoconjunctivitis sicca (HP:0001097)2.49969748
49Large for gestational age (HP:0001520)2.48802948
50Intestinal atresia (HP:0011100)2.46097623
51Attenuation of retinal blood vessels (HP:0007843)2.45589923
52Nasolacrimal duct obstruction (HP:0000579)2.44249945
53T lymphocytopenia (HP:0005403)2.42692104
54Arterial tortuosity (HP:0005116)2.40990721
55Granulocytopenia (HP:0001913)2.38146041
56Aplasia/hypoplasia of the uterus (HP:0008684)2.37684947
57Thyroiditis (HP:0100646)2.35812743
58Joint swelling (HP:0001386)2.35570197
59Conical tooth (HP:0000698)2.35283785
60Eosinophilia (HP:0001880)2.35261385
61Type II lissencephaly (HP:0007260)2.33029742
62Alveolar cell carcinoma (HP:0006519)2.32468021
63Chronic sinusitis (HP:0011109)2.32337460
64Cupped ear (HP:0000378)2.31564064
65Vascular tortuosity (HP:0004948)2.30947484
66Abnormality of the nasal septum (HP:0000419)2.29356606
67Vasculitis (HP:0002633)2.29346194
68Symptomatic seizures (HP:0011145)2.29206406
69Abnormal rod and cone electroretinograms (HP:0008323)2.28020385
70Nephronophthisis (HP:0000090)2.27844421
71Pulmonary fibrosis (HP:0002206)2.25028164
72Gastrointestinal atresia (HP:0002589)2.23294425
73Stenosis of the external auditory canal (HP:0000402)2.22663044
74Segmental peripheral demyelination/remyelination (HP:0003481)2.20811148
75Gastrointestinal infarctions (HP:0005244)2.19840398
76Type I transferrin isoform profile (HP:0003642)2.19382180
77Pancreatic fibrosis (HP:0100732)2.17411882
78Hypoplasia of dental enamel (HP:0006297)2.16957258
79Renal cortical cysts (HP:0000803)2.16775690
80Abnormality of the renal medulla (HP:0100957)2.15994434
81Keratitis (HP:0000491)2.14454098
82Abnormal drinking behavior (HP:0030082)2.14272267
83Polydipsia (HP:0001959)2.14272267
84Mixed hearing impairment (HP:0000410)2.13755066
85Abnormality of the pleura (HP:0002103)2.13495469
86Abnormal respiratory motile cilium physiology (HP:0012261)2.12618575
87Hemiparesis (HP:0001269)2.12312032
88Metaphyseal dysplasia (HP:0100255)2.11350403
89Aplasia involving bones of the extremities (HP:0009825)2.11094381
90Aplasia involving bones of the upper limbs (HP:0009823)2.11094381
91Aplasia of the phalanges of the hand (HP:0009802)2.11094381
92Abnormality of the prostate (HP:0008775)2.10866349
93Hypoplasia of the uterus (HP:0000013)2.08861858
94Episodic fever (HP:0001954)2.08392873
95Abnormal sex determination (HP:0012244)2.08370283
96Sex reversal (HP:0012245)2.08370283
97Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06139064
98Agitation (HP:0000713)2.05991508
99Increased neuronal autofluorescent lipopigment (HP:0002074)2.05538435
100Neoplasm of the tracheobronchial system (HP:0100552)2.05249804
101Encephalitis (HP:0002383)2.04824223
102Amyloidosis (HP:0011034)2.03681405
103Pulmonary artery stenosis (HP:0004415)2.03052005
104Abnormality of calcium-phosphate metabolism (HP:0100530)2.02595251
105Recurrent abscess formation (HP:0002722)2.01674300
106Spondylolisthesis (HP:0003302)2.01437215
107Generalized aminoaciduria (HP:0002909)2.01294767
108Petechiae (HP:0000967)2.00751620
109Arterial thrombosis (HP:0004420)2.00663935
110Milia (HP:0001056)2.00583602
111Facial diplegia (HP:0001349)2.00357177
112Mediastinal lymphadenopathy (HP:0100721)2.00056291
113Eczematoid dermatitis (HP:0000976)1.99344482
114Asplenia (HP:0001746)1.98541220
115Follicular hyperkeratosis (HP:0007502)1.98360600
116Onycholysis (HP:0001806)1.97459966
117Hemiplegia (HP:0002301)1.94807758
118Abnormal respiratory motile cilium morphology (HP:0005938)1.94665981
119Abnormal respiratory epithelium morphology (HP:0012253)1.94665981
120Hypoglycemic seizures (HP:0002173)1.93234690
121Vertigo (HP:0002321)1.92857167
122Macular degeneration (HP:0000608)1.92091171
123Decreased circulating renin level (HP:0003351)1.91647957
124Abnormality of secondary sexual hair (HP:0009888)1.91127096
125Abnormality of the axillary hair (HP:0100134)1.91127096
126Xerostomia (HP:0000217)1.91108074
127Hypergonadotropic hypogonadism (HP:0000815)1.90369135
128Broad face (HP:0000283)1.89685548
129Combined immunodeficiency (HP:0005387)1.89422222
130Hypoplasia of the iris (HP:0007676)1.88963099
131Epistaxis (HP:0000421)1.88683872
132Recurrent skin infections (HP:0001581)1.88239774
133Papilledema (HP:0001085)1.87318662
134Hyperkalemia (HP:0002153)1.86155677
135Anorexia (HP:0002039)1.85535888
136Amelogenesis imperfecta (HP:0000705)1.85459458
137Urethral obstruction (HP:0000796)1.85067516
138Abnormality of the lacrimal duct (HP:0011481)1.84376085
139Hyperactive renin-angiotensin system (HP:0000841)1.83800429
140Abnormality of the nasolacrimal system (HP:0000614)1.83394543
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.83188132
142Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82529417
143Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82221560
144Abnormality of polysaccharide metabolism (HP:0011012)1.82221560
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82221560
146Recurrent bacterial skin infections (HP:0005406)1.81016306
147Diplopia (HP:0000651)1.80523891
148Abnormality of binocular vision (HP:0011514)1.80523891
149Impaired platelet aggregation (HP:0003540)1.80283577
150Abnormal platelet function (HP:0011869)1.80283577
151Pulmonary embolism (HP:0002204)1.79547185
152Spontaneous hematomas (HP:0007420)1.78819617
153Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78460063
154Increased IgE level (HP:0003212)1.78111905
155Interstitial pulmonary disease (HP:0006530)1.77935829
156Inflammation of the large intestine (HP:0002037)1.77177865
157Decreased central vision (HP:0007663)1.76752810
158Esophageal atresia (HP:0002032)1.76636963
159Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76515283
160Thrombocytosis (HP:0001894)1.76105760
161Portal hypertension (HP:0001409)1.75253279
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.75122476
163Dysostosis multiplex (HP:0000943)1.73691792
164Meningitis (HP:0001287)1.73665426
165Medial flaring of the eyebrow (HP:0010747)1.73502334
166Abnormality of B cell number (HP:0010975)1.73128153
167Gangrene (HP:0100758)1.73067651
168Abnormality of the dental pulp (HP:0006479)1.73024217
169Progressive neurologic deterioration (HP:0002344)1.72982027
170Chest pain (HP:0100749)1.72139014
171Short tibia (HP:0005736)1.71393796
172Upper limb muscle weakness (HP:0003484)1.71067648
173Congenital, generalized hypertrichosis (HP:0004540)1.70851094
174Oligodontia (HP:0000677)1.70356587
175Autoimmune thrombocytopenia (HP:0001973)1.70285591
176Anhidrosis (HP:0000970)1.69876691
177Nephrotic syndrome (HP:0000100)1.69853039
178Supernumerary bones of the axial skeleton (HP:0009144)1.69071410
179Cheilitis (HP:0100825)1.68101941
180Rhinitis (HP:0012384)1.67355602
181Abnormality of male internal genitalia (HP:0000022)1.67338661
182Thyroid-stimulating hormone excess (HP:0002925)1.66713763
183Distal lower limb muscle weakness (HP:0009053)1.66639836
184Laryngomalacia (HP:0001601)1.66453959
185Acne (HP:0001061)1.66051092
186Broad nasal tip (HP:0000455)1.65292253
187Abnormality of the columella (HP:0009929)1.61915695
188Ulnar claw (HP:0001178)1.61775188
189Plantar hyperkeratosis (HP:0007556)1.61731485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.60691797
2TAOK34.78210526
3TIE13.71812817
4GRK63.57047799
5TGFBR23.11370394
6* MAP2K22.63228794
7MAPKAPK52.63017783
8VRK12.52308160
9FRK2.39107818
10MAP3K22.07595838
11INSRR1.93864384
12EPHB11.85805423
13PIK3CG1.84204347
14GRK71.84163050
15HIPK21.80436023
16MAP3K141.78532338
17PIM21.66918073
18MAP3K31.66459103
19TLK11.60120857
20BMPR1B1.59648321
21MAP4K21.59275345
22MUSK1.58113605
23ZAP701.56484315
24NUAK11.51548819
25KDR1.48213502
26TGFBR11.44815240
27IRAK31.43234364
28KIT1.41345534
29CDK31.31689068
30TNK21.29796043
31MAP3K121.29729571
32SYK1.24682988
33RIPK41.23833606
34TSSK61.19574042
35PINK11.12850999
36MYLK1.11346802
37NLK1.09979314
38CDK81.09613312
39MAP2K11.02823364
40JAK31.01548462
41ADRBK21.01498260
42IKBKE1.01303323
43MOS1.00512457
44CASK0.98989787
45TEC0.97463587
46MAPKAPK30.91935244
47DYRK30.90705548
48EPHA30.87850172
49PAK20.85999800
50TNIK0.84737207
51PIM10.83761758
52IRAK40.83728826
53TYK20.82185825
54CHUK0.81884390
55HCK0.81418266
56CAMKK20.81390123
57GSK3A0.81159039
58PRKG20.80937176
59MAP3K130.80488799
60TRPM70.80120438
61DAPK20.79317237
62BCKDK0.79237822
63WNK40.78508814
64PASK0.78502671
65MAPKAPK20.78100972
66PIK3CA0.76901676
67TBK10.76232206
68PAK30.75313367
69PTK2B0.75176976
70NEK60.74876014
71BTK0.74121234
72IRAK10.72824977
73ERBB30.72175001
74PRKCQ0.71561972
75MARK30.71492683
76TESK20.66997138
77CDK190.64626758
78STK100.62355075
79GRK10.61011596
80RIPK10.60814093
81MAPK130.59484301
82MATK0.58816056
83RPS6KA50.58811903
84ABL10.58757659
85* MAPK30.58437831
86FER0.57939703
87* MAPK40.56952050
88BRD40.56258733
89FES0.55408244
90* IKBKB0.55382447
91FLT30.54726131
92MKNK20.53989114
93MAP3K10.53450543
94JAK20.53142000
95CDK90.52039544
96ITK0.51951610
97BMPR20.51711394
98PRKD20.51571483
99CAMK10.51359535
100OXSR10.51018554
101MST40.49456971
102CSF1R0.49100155
103PDK20.47278636
104ERBB20.46556459
105TXK0.45993373
106SIK20.45283847
107* MAPK70.44445902
108MAP2K30.43621284
109STK390.42542147
110CLK10.42031420
111PRKCE0.41665878
112GRK50.40929772
113MAP3K70.39097168
114MKNK10.38972744
115* RPS6KA10.38299883
116EIF2AK20.37938515
117PRKD10.37399438
118MAP4K10.35691267
119FGFR30.35554231
120MAP2K60.35499797
121MAPK120.35354694
122PHKG20.35254788
123PHKG10.35254788
124MARK20.35098054
125PDK10.34416642
126ADRBK10.33661492
127JAK10.33490335
128CSK0.33417026
129IGF1R0.33066370
130* MAPK10.32856230
131RPS6KB20.32427391
132ZAK0.32235833
133BLK0.32032203
134CAMK40.31798111
135LYN0.31571518
136SGK4940.31496074
137SGK2230.31496074
138LCK0.30515262

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.59022864
2Primary immunodeficiency_Homo sapiens_hsa053402.60017812
3Protein export_Homo sapiens_hsa030602.24533879
4Graft-versus-host disease_Homo sapiens_hsa053322.23823088
5Allograft rejection_Homo sapiens_hsa053302.20100956
6Asthma_Homo sapiens_hsa053102.17616961
7Autoimmune thyroid disease_Homo sapiens_hsa053202.05850679
8Notch signaling pathway_Homo sapiens_hsa043302.02262624
9Type I diabetes mellitus_Homo sapiens_hsa049401.93972939
10* Osteoclast differentiation_Homo sapiens_hsa043801.81862037
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81446376
12Sulfur metabolism_Homo sapiens_hsa009201.74320604
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71714631
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66501586
15Cocaine addiction_Homo sapiens_hsa050301.64663290
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60642923
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.58821129
18Staphylococcus aureus infection_Homo sapiens_hsa051501.53803290
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53407738
20Nitrogen metabolism_Homo sapiens_hsa009101.52575077
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39683433
22Phototransduction_Homo sapiens_hsa047441.38643712
23* TNF signaling pathway_Homo sapiens_hsa046681.35779853
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35670730
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35488174
26Prion diseases_Homo sapiens_hsa050201.32454924
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32091806
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30023860
29Sphingolipid metabolism_Homo sapiens_hsa006001.29536937
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25413982
31Malaria_Homo sapiens_hsa051441.24883784
32* Rheumatoid arthritis_Homo sapiens_hsa053231.23589479
33Other glycan degradation_Homo sapiens_hsa005111.23259823
34African trypanosomiasis_Homo sapiens_hsa051431.22151085
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20537011
36Hematopoietic cell lineage_Homo sapiens_hsa046401.20117914
37ECM-receptor interaction_Homo sapiens_hsa045121.17172373
38Platelet activation_Homo sapiens_hsa046111.16059397
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16010111
40* B cell receptor signaling pathway_Homo sapiens_hsa046621.14576298
41* Leishmaniasis_Homo sapiens_hsa051401.13621373
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.12657115
43Circadian rhythm_Homo sapiens_hsa047101.11402121
44Caffeine metabolism_Homo sapiens_hsa002321.07785986
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06437431
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05567031
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05535181
48Chemical carcinogenesis_Homo sapiens_hsa052041.02660754
49Tryptophan metabolism_Homo sapiens_hsa003801.02419929
50Arachidonic acid metabolism_Homo sapiens_hsa005901.02067077
51* Pertussis_Homo sapiens_hsa051330.99151472
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98653380
53Regulation of autophagy_Homo sapiens_hsa041400.98244800
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98217022
55Ether lipid metabolism_Homo sapiens_hsa005650.95832199
56Serotonergic synapse_Homo sapiens_hsa047260.93769698
57* MAPK signaling pathway_Homo sapiens_hsa040100.93541592
58* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91562793
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91062289
60* Herpes simplex infection_Homo sapiens_hsa051680.90995880
61* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90683691
62Salivary secretion_Homo sapiens_hsa049700.89756397
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.86806671
64Toxoplasmosis_Homo sapiens_hsa051450.86034229
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.85947047
66TGF-beta signaling pathway_Homo sapiens_hsa043500.83623459
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.81882449
68Wnt signaling pathway_Homo sapiens_hsa043100.81210074
69Tuberculosis_Homo sapiens_hsa051520.80353949
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.79070754
71Influenza A_Homo sapiens_hsa051640.78941397
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78609977
73Ovarian steroidogenesis_Homo sapiens_hsa049130.76647275
74Olfactory transduction_Homo sapiens_hsa047400.76334883
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76309122
76Antigen processing and presentation_Homo sapiens_hsa046120.75606327
77Focal adhesion_Homo sapiens_hsa045100.75013158
78Glycerolipid metabolism_Homo sapiens_hsa005610.73324219
79Fatty acid elongation_Homo sapiens_hsa000620.72013429
80Acute myeloid leukemia_Homo sapiens_hsa052210.71768293
81Hepatitis C_Homo sapiens_hsa051600.71565207
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.68360925
83Morphine addiction_Homo sapiens_hsa050320.67978765
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67642473
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67422593
86* Estrogen signaling pathway_Homo sapiens_hsa049150.67407695
87* HTLV-I infection_Homo sapiens_hsa051660.67367435
88Prostate cancer_Homo sapiens_hsa052150.67081681
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66808160
90Measles_Homo sapiens_hsa051620.66776364
91Taste transduction_Homo sapiens_hsa047420.66491593
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66468066
93ABC transporters_Homo sapiens_hsa020100.66102143
94Lysosome_Homo sapiens_hsa041420.65573487
95Insulin secretion_Homo sapiens_hsa049110.65228232
96* Apoptosis_Homo sapiens_hsa042100.63989977
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63848508
98GnRH signaling pathway_Homo sapiens_hsa049120.63824829
99Amoebiasis_Homo sapiens_hsa051460.63694301
100* Hepatitis B_Homo sapiens_hsa051610.63278703
101Histidine metabolism_Homo sapiens_hsa003400.62408811
102Chemokine signaling pathway_Homo sapiens_hsa040620.62181172
103Renal cell carcinoma_Homo sapiens_hsa052110.61779219
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.61418058
105Legionellosis_Homo sapiens_hsa051340.59983512
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59474595
107Vitamin digestion and absorption_Homo sapiens_hsa049770.59468980
108* Amphetamine addiction_Homo sapiens_hsa050310.59305711
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58950079
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58843498
111Ras signaling pathway_Homo sapiens_hsa040140.58162777
112* Pathways in cancer_Homo sapiens_hsa052000.57679534
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.57456712
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57309364
115* T cell receptor signaling pathway_Homo sapiens_hsa046600.56518872
116Protein digestion and absorption_Homo sapiens_hsa049740.55980861
117Rap1 signaling pathway_Homo sapiens_hsa040150.55533477
118Chronic myeloid leukemia_Homo sapiens_hsa052200.54943345
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54573126
120ErbB signaling pathway_Homo sapiens_hsa040120.54484588
121Galactose metabolism_Homo sapiens_hsa000520.54083056
122Viral myocarditis_Homo sapiens_hsa054160.53753958
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53734838
124Linoleic acid metabolism_Homo sapiens_hsa005910.53686158
125Vibrio cholerae infection_Homo sapiens_hsa051100.53039106
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52777395
127Dorso-ventral axis formation_Homo sapiens_hsa043200.51780809
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51260060
129Renin secretion_Homo sapiens_hsa049240.49987326
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.49500614
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48829299
132* cAMP signaling pathway_Homo sapiens_hsa040240.45510909
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42166648
134Butanoate metabolism_Homo sapiens_hsa006500.40005956
135Gastric acid secretion_Homo sapiens_hsa049710.39423162
136Calcium signaling pathway_Homo sapiens_hsa040200.37128840
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.36639202

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