FOSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.41449929
2skin morphogenesis (GO:0043589)6.08357283
3hemidesmosome assembly (GO:0031581)5.77948607
4wound healing, spreading of epidermal cells (GO:0035313)5.72184244
5chondrocyte proliferation (GO:0035988)4.93965542
6protein maturation by protein folding (GO:0022417)4.91085685
7wound healing, spreading of cells (GO:0044319)4.87629232
8COPI coating of Golgi vesicle (GO:0048205)4.68664542
9Golgi transport vesicle coating (GO:0048200)4.68664542
10keratinocyte proliferation (GO:0043616)4.42036622
11cell adhesion mediated by integrin (GO:0033627)4.26872751
12collagen fibril organization (GO:0030199)4.24193638
13positive regulation of endothelial cell apoptotic process (GO:2000353)4.05929128
14establishment of integrated proviral latency (GO:0075713)3.97532165
15protein retention in ER lumen (GO:0006621)3.89886616
16negative regulation of fatty acid transport (GO:2000192)3.87949408
17activation of Rac GTPase activity (GO:0032863)3.84654859
18negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.83175368
19endodermal cell differentiation (GO:0035987)3.81218137
20regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.77150710
21regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.71650682
22cell-substrate junction assembly (GO:0007044)3.71550631
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.70498527
24substrate-dependent cell migration (GO:0006929)3.66680240
25establishment of viral latency (GO:0019043)3.66493204
26regulation of tight junction assembly (GO:2000810)3.57144177
27muscle cell migration (GO:0014812)3.55512202
28mesodermal cell differentiation (GO:0048333)3.51953337
29barbed-end actin filament capping (GO:0051016)3.48537504
30hypotonic response (GO:0006971)3.47302676
31mesenchymal-epithelial cell signaling (GO:0060638)3.44905789
32trophoblast giant cell differentiation (GO:0060707)3.30751184
33atrioventricular valve morphogenesis (GO:0003181)3.30620328
34regulation of translational termination (GO:0006449)3.30491863
35type B pancreatic cell proliferation (GO:0044342)3.27437953
36DNA unwinding involved in DNA replication (GO:0006268)3.26256762
37heterochromatin organization (GO:0070828)3.24041846
38endothelial cell chemotaxis (GO:0035767)3.19546248
39keratinocyte differentiation (GO:0030216)3.17736051
40actin filament depolymerization (GO:0030042)3.17675947
41negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.17124775
42regulation of water loss via skin (GO:0033561)3.17008723
43negative regulation of smooth muscle cell migration (GO:0014912)3.15858041
44mammary gland epithelial cell proliferation (GO:0033598)3.15013331
45positive regulation of pseudopodium assembly (GO:0031274)3.13530857
46negative regulation of anoikis (GO:2000811)3.12283929
47cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.12053813
48cell-substrate adherens junction assembly (GO:0007045)3.11952882
49focal adhesion assembly (GO:0048041)3.11952882
50viral transcription (GO:0019083)3.10200203
51mRNA transcription (GO:0009299)3.10128339
52negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.09730548
53ribosomal small subunit biogenesis (GO:0042274)3.09368641
54mitotic chromosome condensation (GO:0007076)3.08700317
55negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.07023730
56positive regulation of blood vessel endothelial cell migration (GO:0043536)3.06937288
57positive regulation of astrocyte differentiation (GO:0048711)3.06634425
58epithelial cell-cell adhesion (GO:0090136)3.06379838
59regulation of metalloenzyme activity (GO:0048552)3.06366114
60pinocytosis (GO:0006907)3.05963730
61translational termination (GO:0006415)3.05092656
62positive regulation of osteoblast proliferation (GO:0033690)3.03998341
63peptidyl-proline hydroxylation (GO:0019511)3.03159961
64cellular response to interferon-alpha (GO:0035457)3.03033832
65interferon-gamma secretion (GO:0072643)3.02715229
66sequestering of extracellular ligand from receptor (GO:0035581)2.99722951
67decidualization (GO:0046697)2.98404642
68SMAD protein complex assembly (GO:0007183)2.96145998
69nucleobase-containing small molecule interconversion (GO:0015949)2.94621722
70regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94536930
71dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.93319044
72regulation of mitotic spindle organization (GO:0060236)2.93110045
73adherens junction assembly (GO:0034333)2.92764720
74cellular response to vitamin D (GO:0071305)2.92318809
75positive regulation of macrophage activation (GO:0043032)2.91377016
76regulation of chemokine secretion (GO:0090196)2.90588659
77regulation of vitamin D biosynthetic process (GO:0060556)2.87909178
78lymphangiogenesis (GO:0001946)2.86207334
79plasma membrane repair (GO:0001778)2.86152873
80regulation of anoikis (GO:2000209)2.84745605
81positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.84637286
82cellular response to vitamin (GO:0071295)2.84536896
83cellular copper ion homeostasis (GO:0006878)2.84015127
84regulation of integrin-mediated signaling pathway (GO:2001044)2.82863890
85endothelial cell morphogenesis (GO:0001886)2.82654804
86mitotic nuclear envelope reassembly (GO:0007084)2.82562410
87nuclear envelope reassembly (GO:0031468)2.82562410
88wound healing (GO:0042060)2.81410873
89stress fiber assembly (GO:0043149)2.78503406
90kidney mesenchyme development (GO:0072074)2.78452975
91ribosome assembly (GO:0042255)2.76276031
92apoptotic cell clearance (GO:0043277)2.75512431
93regulation of pseudopodium assembly (GO:0031272)2.72909597
94positive regulation of p38MAPK cascade (GO:1900745)2.72747772
95low-density lipoprotein particle clearance (GO:0034383)2.71656589
96eyelid development in camera-type eye (GO:0061029)2.70876185
97cell differentiation involved in embryonic placenta development (GO:0060706)2.70484536
98positive regulation of extracellular matrix organization (GO:1903055)2.70343293
99regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.69545519
100cell migration involved in sprouting angiogenesis (GO:0002042)2.68970993
101UV protection (GO:0009650)2.67504187
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67224212
103dermatan sulfate biosynthetic process (GO:0030208)2.66825417
104hippo signaling (GO:0035329)2.66512199
105positive regulation of epithelial to mesenchymal transition (GO:0010718)2.66103207
106retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.65863245
107extracellular fibril organization (GO:0043206)2.65685525
108collagen metabolic process (GO:0032963)2.64577627
109mitotic metaphase plate congression (GO:0007080)2.63987829
110substrate adhesion-dependent cell spreading (GO:0034446)2.63979168
111cartilage morphogenesis (GO:0060536)2.63376707
112endocytic recycling (GO:0032456)2.62108116
113myeloid cell homeostasis (GO:0002262)2.61514734
114protein heterotrimerization (GO:0070208)2.61429051
115nucleotide-sugar biosynthetic process (GO:0009226)2.60902386
116establishment of skin barrier (GO:0061436)2.60668254
117protein localization to cell surface (GO:0034394)2.59962439
118establishment of endothelial barrier (GO:0061028)2.59711703
119positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.59543943
120protein localization to endosome (GO:0036010)2.59403484
121protein localization to microtubule (GO:0035372)2.58213324
122regulation of early endosome to late endosome transport (GO:2000641)2.57345751
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.56876560
124membrane raft organization (GO:0031579)2.56224616
125protein hydroxylation (GO:0018126)2.56119430
126regulation of type B pancreatic cell apoptotic process (GO:2000674)2.55547481
127mitotic sister chromatid segregation (GO:0000070)2.54783322
128translational elongation (GO:0006414)2.53925109
129prostanoid biosynthetic process (GO:0046457)2.53425096
130prostaglandin biosynthetic process (GO:0001516)2.53425096
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.53371982
132mitotic cytokinesis (GO:0000281)2.53016799
133neural crest cell development (GO:0014032)2.52206128
134positive regulation of actin filament depolymerization (GO:0030836)2.52147143
135regulation of integrin activation (GO:0033623)2.52132437
136regulation of spindle organization (GO:0090224)2.52112366
137protein targeting to ER (GO:0045047)2.52057223
138regulation of vitamin metabolic process (GO:0030656)2.50643494
139lung vasculature development (GO:0060426)2.50319812
140collagen catabolic process (GO:0030574)2.49971356
141maturation of SSU-rRNA (GO:0030490)2.49352524
142extracellular matrix disassembly (GO:0022617)2.49258622
143negative regulation of chondrocyte differentiation (GO:0032331)2.48776198
144hyaluronan catabolic process (GO:0030214)2.48622420
145negative regulation of JAK-STAT cascade (GO:0046426)2.48316814
146cellular response to arsenic-containing substance (GO:0071243)2.48068033
147negative regulation of catenin import into nucleus (GO:0035414)2.47899722
148negative regulation of keratinocyte proliferation (GO:0010839)2.47323682
149epithelial to mesenchymal transition (GO:0001837)2.46545276
150regulation of cell aging (GO:0090342)2.45210027
151UDP-N-acetylglucosamine metabolic process (GO:0006047)2.44479750
152cotranslational protein targeting to membrane (GO:0006613)2.44304631
153blood vessel endothelial cell migration (GO:0043534)2.43967494
154cellular protein complex disassembly (GO:0043624)2.43719910
155establishment of protein localization to endoplasmic reticulum (GO:0072599)2.43342190
156multicellular organismal macromolecule metabolic process (GO:0044259)2.42880555
157basement membrane organization (GO:0071711)2.41964542
158cortical actin cytoskeleton organization (GO:0030866)2.41923250
159fibroblast migration (GO:0010761)2.41719610
160cyclooxygenase pathway (GO:0019371)2.41176894
161ventricular cardiac muscle cell development (GO:0055015)2.40424636
162regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.40369752
163lipopolysaccharide biosynthetic process (GO:0009103)2.40189773
164pyrimidine nucleoside salvage (GO:0043097)2.39629547
165pyrimidine-containing compound salvage (GO:0008655)2.39629547
166vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.37707320
167regulation of apoptotic process involved in morphogenesis (GO:1902337)2.35809241
168endoplasmic reticulum unfolded protein response (GO:0030968)2.33465728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.28860547
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.02753132
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.08890309
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.60393535
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.52886349
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.39416248
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.00841923
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.90271184
9* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.66782137
10* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.66782137
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.65898164
12CLOCK_20551151_ChIP-Seq_293T_Human2.60797837
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.55923481
14* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.52712496
15* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.44917148
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.23257543
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17334953
18* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17159466
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16468958
20CJUN_26792858_Chip-Seq_BT549_Human2.15108347
21* ATF3_27146783_Chip-Seq_COLON_Human2.08640293
22* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.08546023
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.06047291
24TP63_17297297_ChIP-ChIP_HaCaT_Human11.1806994
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.98365055
26* ELK3_25401928_ChIP-Seq_HUVEC_Human1.96560287
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95040167
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94713568
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.88902492
30BRD4_25478319_ChIP-Seq_HGPS_Human1.85686936
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84768057
32E2F7_22180533_ChIP-Seq_HELA_Human1.82918568
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.81643202
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.77500297
35* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.77148311
36JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77111002
37* UBF1/2_26484160_Chip-Seq_HMECs_Human1.72766975
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66732064
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65402150
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61449041
41JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61272611
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60608662
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.58696267
44SOX2_20726797_ChIP-Seq_SW620_Human1.58619979
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.56354603
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56096717
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.54972730
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.53791275
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51852132
50DCP1A_22483619_ChIP-Seq_HELA_Human1.51823739
51* RACK7_27058665_Chip-Seq_MCF-7_Human1.48675365
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48492876
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.46129977
54ZNF263_19887448_ChIP-Seq_K562_Human1.45121443
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43701295
56* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42175491
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41133713
58MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36900477
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35901831
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33900803
61VDR_21846776_ChIP-Seq_THP-1_Human1.32664501
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32599224
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32274646
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32088640
65XRN2_22483619_ChIP-Seq_HELA_Human1.27056794
66* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26355116
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26241910
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26241910
69* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25770219
70EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.25186558
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25040979
72* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24541344
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22701746
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21990881
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20898805
76* TP53_22127205_ChIP-Seq_IMR90_Human1.20580983
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20563350
78SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19778247
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19020555
80* TET1_21451524_ChIP-Seq_MESCs_Mouse1.18722566
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17862124
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17404029
83TP53_18474530_ChIP-ChIP_U2OS_Human1.16398793
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13739476
85* KLF5_25053715_ChIP-Seq_YYC3_Human1.13191405
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11322727
87MYC_18555785_ChIP-Seq_MESCs_Mouse1.11136119
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10595746
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.08785143
90TP53_16413492_ChIP-PET_HCT116_Human1.06313028
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05033881
92* TP53_20018659_ChIP-ChIP_R1E_Mouse1.04916817
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04584297
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.03220379
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02641687
96* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02311024
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.02248901
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01496915
99TFEB_21752829_ChIP-Seq_HELA_Human1.00220157
100GABP_19822575_ChIP-Seq_HepG2_Human1.00204194
101MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00149081
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99913229
103AR_21909140_ChIP-Seq_LNCAP_Human0.99555006
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99398759
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98946392
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97349609
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96215769
108* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94444708
109GATA6_25053715_ChIP-Seq_YYC3_Human0.94152087
110CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93280004
111ETS1_20019798_ChIP-Seq_JURKAT_Human0.92874046
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92483928
113BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92051244
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91680064
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91037485
116* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89745778
117* TP53_23651856_ChIP-Seq_MEFs_Mouse0.88792706
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88450034
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88283588
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88115047
121* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88111707
122EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87528396
123TCF7_22412390_ChIP-Seq_EML_Mouse0.86984348
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84533538
125GATA3_24758297_ChIP-Seq_MCF-7_Human0.84427200
126RXR_22108803_ChIP-Seq_LS180_Human0.83853548
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83419770
128TCF4_18268006_ChIP-ChIP_LS174T_Human0.82541006
129MYC_22102868_ChIP-Seq_BL_Human0.81016498
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.80158394
131STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.80103285
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.79357143
133KDM2B_26808549_Chip-Seq_DND41_Human0.79335427
134LXR_22292898_ChIP-Seq_THP-1_Human0.78708699
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78200676
136* CHD1_26751641_Chip-Seq_LNCaP_Human0.77408023
137SMC3_22415368_ChIP-Seq_MEFs_Mouse0.76639498
138NCOR1_26117541_ChIP-Seq_K562_Human0.75670783
139FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75061263
140KDM2B_26808549_Chip-Seq_K562_Human0.72916543
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72337047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.52536294
2MP0008438_abnormal_cutaneous_collagen4.06727430
3MP0005275_abnormal_skin_tensile3.70072040
4MP0010352_gastrointestinal_tract_polyps3.55647648
5MP0003566_abnormal_cell_adhesion3.09378149
6MP0005023_abnormal_wound_healing2.95046538
7MP0002060_abnormal_skin_morphology2.68144827
8MP0003191_abnormal_cellular_cholesterol2.56270692
9MP0003279_aneurysm2.51883195
10MP0005503_abnormal_tendon_morphology2.49716099
11MP0003941_abnormal_skin_development2.43843330
12MP0002796_impaired_skin_barrier2.42746011
13MP0002877_abnormal_melanocyte_morpholog2.39003397
14MP0003091_abnormal_cell_migration2.37572927
15MP0003453_abnormal_keratinocyte_physiol2.32527965
16MP0010030_abnormal_orbit_morphology2.29492832
17MP0005623_abnormal_meninges_morphology2.25143563
18MP0005076_abnormal_cell_differentiation2.22972035
19MP0004272_abnormal_basement_membrane2.14757218
20MP0009840_abnormal_foam_cell2.08065485
21MP0000751_myopathy2.05847879
22MP0000750_abnormal_muscle_regeneration2.05280018
23MP0001958_emphysema1.99590149
24MP0005501_abnormal_skin_physiology1.90860544
25MP0009384_cardiac_valve_regurgitation1.85885118
26MP0001216_abnormal_epidermal_layer1.85260445
27MP0005508_abnormal_skeleton_morphology1.83651671
28MP0009053_abnormal_anal_canal1.70887635
29MP0001243_abnormal_dermal_layer1.69677589
30MP0003950_abnormal_plasma_membrane1.63934288
31MP0000537_abnormal_urethra_morphology1.61907165
32MP0001542_abnormal_bone_strength1.60187170
33MP0005451_abnormal_body_composition1.59091775
34MP0010234_abnormal_vibrissa_follicle1.58600950
35MP0008004_abnormal_stomach_pH1.56626983
36MP0000749_muscle_degeneration1.55664177
37MP0000733_abnormal_muscle_development1.55640346
38MP0002933_joint_inflammation1.54882998
39MP0009250_abnormal_appendicular_skeleto1.54191705
40MP0010771_integument_phenotype1.52362647
41MP0010368_abnormal_lymphatic_system1.49628247
42MP0001849_ear_inflammation1.46779238
43MP0000762_abnormal_tongue_morphology1.42584485
44MP0002282_abnormal_trachea_morphology1.41653539
45MP0002896_abnormal_bone_mineralization1.40390025
46MP0005390_skeleton_phenotype1.40387714
47MP0004947_skin_inflammation1.38587210
48MP0005257_abnormal_intraocular_pressure1.38192193
49MP0006054_spinal_hemorrhage1.37712871
50MP0005165_increased_susceptibility_to1.36310398
51MP0002332_abnormal_exercise_endurance1.36194483
52MP0004858_abnormal_nervous_system1.34304246
53MP0001299_abnormal_eye_distance/1.30399423
54MP0000858_altered_metastatic_potential1.29787488
55MP0003303_peritoneal_inflammation1.29704129
56MP0003436_decreased_susceptibility_to1.27426733
57MP0003806_abnormal_nucleotide_metabolis1.26427956
58MP0003300_gastrointestinal_ulcer1.26377588
59MP0000377_abnormal_hair_follicle1.26118026
60MP0001533_abnormal_skeleton_physiology1.23399237
61MP0004233_abnormal_muscle_weight1.23219224
62MP0002295_abnormal_pulmonary_circulatio1.22831128
63MP0000163_abnormal_cartilage_morphology1.22793112
64MP0003755_abnormal_palate_morphology1.21200382
65MP0005058_abnormal_lysosome_morphology1.17167501
66MP0000534_abnormal_ureter_morphology1.15740085
67MP0003111_abnormal_nucleus_morphology1.14522223
68MP0004957_abnormal_blastocyst_morpholog1.12061049
69MP0005197_abnormal_uvea_morphology1.11578577
70MP0003448_altered_tumor_morphology1.10858876
71MP0000767_abnormal_smooth_muscle1.10377252
72MP0008932_abnormal_embryonic_tissue1.08530133
73MP0001191_abnormal_skin_condition1.07685093
74MP0000467_abnormal_esophagus_morphology1.06038450
75MP0000383_abnormal_hair_follicle1.05022870
76MP0009780_abnormal_chondrocyte_physiolo1.04791273
77MP0005621_abnormal_cell_physiology1.04634170
78MP0009379_abnormal_foot_pigmentation1.03461093
79MP0009931_abnormal_skin_appearance1.03237995
80MP0000759_abnormal_skeletal_muscle1.01772319
81MP0002113_abnormal_skeleton_development1.00851109
82MP0000013_abnormal_adipose_tissue1.00723066
83MP0003385_abnormal_body_wall1.00477227
84MP0009697_abnormal_copulation1.00318290
85MP0005164_abnormal_response_to0.99932238
86MP0001851_eye_inflammation0.99907707
87MP0000647_abnormal_sebaceous_gland0.98709387
88MP0000350_abnormal_cell_proliferation0.97955373
89MP0002115_abnormal_skeleton_extremities0.97536407
90MP0001879_abnormal_lymphatic_vessel0.95356883
91MP0004510_myositis0.93475411
92MP0000627_abnormal_mammary_gland0.93446247
93MP0010678_abnormal_skin_adnexa0.91565383
94MP0002234_abnormal_pharynx_morphology0.90310718
95MP0001340_abnormal_eyelid_morphology0.90284112
96MP0002098_abnormal_vibrissa_morphology0.90235981
97* MP0003795_abnormal_bone_structure0.89542259
98MP0000358_abnormal_cell_content/0.89310954
99MP0003315_abnormal_perineum_morphology0.89294483
100MP0003077_abnormal_cell_cycle0.88222996
101MP0002254_reproductive_system_inflammat0.88209078
102MP0005330_cardiomyopathy0.87267868
103MP0001730_embryonic_growth_arrest0.86707074
104MP0003693_abnormal_embryo_hatching0.85857941
105MP0005375_adipose_tissue_phenotype0.85832769
106MP0001346_abnormal_lacrimal_gland0.85593843
107MP0001853_heart_inflammation0.85457511
108MP0005595_abnormal_vascular_smooth0.84566705
109MP0008260_abnormal_autophagy0.82976373
110MP0003786_premature_aging0.82151179
111MP0000003_abnormal_adipose_tissue0.81881348
112MP0003045_fibrosis0.81842704
113MP0004185_abnormal_adipocyte_glucose0.81832966
114* MP0002998_abnormal_bone_remodeling0.80902146
115MP0000343_altered_response_to0.80236921
116MP0000432_abnormal_head_morphology0.78539779
117* MP0002080_prenatal_lethality0.78484018
118MP0003828_pulmonary_edema0.77098654
119MP0005083_abnormal_biliary_tract0.76941596
120MP0003075_altered_response_to0.75971985
121MP0000678_abnormal_parathyroid_gland0.75960833
122MP0004808_abnormal_hematopoietic_stem0.75056288
123MP0005384_cellular_phenotype0.74695618
124MP0003942_abnormal_urinary_system0.73382793
125MP0005193_abnormal_anterior_eye0.72110568
126MP0004087_abnormal_muscle_fiber0.71922600
127MP0008007_abnormal_cellular_replicative0.71912887
128MP0002177_abnormal_outer_ear0.71464562
129MP0001348_abnormal_lacrimal_gland0.71127627
130MP0002111_abnormal_tail_morphology0.70773357
131MP0004197_abnormal_fetal_growth/weight/0.70663197
132MP0000427_abnormal_hair_cycle0.70481431
133MP0002089_abnormal_postnatal_growth/wei0.69910106
134MP0004134_abnormal_chest_morphology0.69437277
135MP0002932_abnormal_joint_morphology0.68597002
136* MP0001614_abnormal_blood_vessel0.68401342
137MP0005670_abnormal_white_adipose0.67221654
138MP0002108_abnormal_muscle_morphology0.66674013
139* MP0002925_abnormal_cardiovascular_devel0.66513171
140MP0005248_abnormal_Harderian_gland0.66264894
141MP0005360_urolithiasis0.65328015
142MP0002128_abnormal_blood_circulation0.65178211
143MP0001915_intracranial_hemorrhage0.64615075

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.38176431
2Protrusio acetabuli (HP:0003179)5.98527282
3Atrophic scars (HP:0001075)4.18925899
4Reduced subcutaneous adipose tissue (HP:0003758)3.71884536
5Increased connective tissue (HP:0009025)3.63345406
6Neonatal short-limb short stature (HP:0008921)3.51661078
7Fragile skin (HP:0001030)3.42852732
8Spinal rigidity (HP:0003306)3.33623757
9Vertebral compression fractures (HP:0002953)3.31444282
10Short nail (HP:0001799)3.31201777
11Distal lower limb amyotrophy (HP:0008944)3.30156653
12Peritonitis (HP:0002586)3.27511557
13Cervical subluxation (HP:0003308)3.26271497
14Shallow orbits (HP:0000586)3.24410045
15Distal lower limb muscle weakness (HP:0009053)3.16875044
16Soft skin (HP:0000977)3.08825267
17Milia (HP:0001056)3.06793427
18Dilatation of the ascending aorta (HP:0005111)2.93570992
19Wormian bones (HP:0002645)2.93274373
20Increased density of long bones (HP:0006392)2.86831920
21Generalized amyotrophy (HP:0003700)2.86418393
22Hyperacusis (HP:0010780)2.77029951
23Right ventricular cardiomyopathy (HP:0011663)2.75988226
24Vascular tortuosity (HP:0004948)2.70334013
25Arterial tortuosity (HP:0005116)2.70159516
26Coxa vara (HP:0002812)2.69680799
27Aortic dissection (HP:0002647)2.69411951
28Ankle contracture (HP:0006466)2.65140213
29Glucose intolerance (HP:0000833)2.64736269
30Aortic aneurysm (HP:0004942)2.63610512
31Genu recurvatum (HP:0002816)2.63500595
32Epiphyseal dysplasia (HP:0002656)2.63078259
33Rough bone trabeculation (HP:0100670)2.61200264
34Abnormality of the distal phalanges of the toes (HP:0010182)2.58049763
35Difficulty climbing stairs (HP:0003551)2.57932441
36Spinal cord lesions (HP:0100561)2.56328699
37Syringomyelia (HP:0003396)2.56328699
38Broad face (HP:0000283)2.56319543
39Cupped ribs (HP:0000887)2.55938253
40Thin bony cortex (HP:0002753)2.53998748
41Axonal loss (HP:0003447)2.45438167
42Osteolytic defects of the hand bones (HP:0009699)2.45333827
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.45333827
44Lower limb amyotrophy (HP:0007210)2.42864652
45Hand muscle atrophy (HP:0009130)2.40863186
46Abnormality of dentin (HP:0010299)2.39717651
47Aplasia involving bones of the extremities (HP:0009825)2.38661202
48Aplasia involving bones of the upper limbs (HP:0009823)2.38661202
49Aplasia of the phalanges of the hand (HP:0009802)2.38661202
50Distal upper limb amyotrophy (HP:0007149)2.38253427
51Upper limb amyotrophy (HP:0009129)2.38253427
52Biconcave vertebral bodies (HP:0004586)2.37645024
53Cerebral aneurysm (HP:0004944)2.35626785
54Nail dystrophy (HP:0008404)2.35102530
55Thick nail (HP:0001805)2.33675094
56Fragile nails (HP:0001808)2.32888472
57Tibial bowing (HP:0002982)2.32787083
58Achilles tendon contracture (HP:0001771)2.31820352
59Cardiovascular calcification (HP:0011915)2.30176083
60Flat acetabular roof (HP:0003180)2.30073629
61Blue sclerae (HP:0000592)2.28673633
62Natal tooth (HP:0000695)2.27693880
63Insomnia (HP:0100785)2.25091673
64Slender build (HP:0001533)2.23092858
65Abnormality of the acetabulum (HP:0003170)2.21511959
66Upper limb muscle weakness (HP:0003484)2.20196616
67Mitral regurgitation (HP:0001653)2.19456196
68Onycholysis (HP:0001806)2.17791744
69Elbow flexion contracture (HP:0002987)2.16217935
70Hypoplastic ischia (HP:0003175)2.16019701
71Abnormality of the calcaneus (HP:0008364)2.15504082
72Insulin resistance (HP:0000855)2.15252108
73Abnormal vertebral ossification (HP:0100569)2.14608420
74Spondylolisthesis (HP:0003302)2.14420645
75Spinal cord compression (HP:0002176)2.14368182
76Vascular calcification (HP:0004934)2.13660684
77Overgrowth (HP:0001548)2.12734427
78Radial bowing (HP:0002986)2.12018411
79Pterygium (HP:0001059)2.11854496
80Trismus (HP:0000211)2.11567116
81Mildly elevated creatine phosphokinase (HP:0008180)2.10141999
82Ulnar bowing (HP:0003031)2.09391298
83Selective tooth agenesis (HP:0001592)2.07740287
84Nuclear cataract (HP:0100018)2.04322052
85Plantar hyperkeratosis (HP:0007556)2.02263231
86Mitral valve prolapse (HP:0001634)2.01844568
87Abnormality of the Achilles tendon (HP:0005109)2.00952532
88Bladder diverticulum (HP:0000015)1.99948273
89Wrist flexion contracture (HP:0001239)1.98662092
90Scapular winging (HP:0003691)1.98580675
91Abnormal trabecular bone morphology (HP:0100671)1.96518844
92Decreased subcutaneous fat (HP:0001002)1.96238941
93Poikiloderma (HP:0001029)1.94390634
94Abnormal hemoglobin (HP:0011902)1.93156342
95Delayed epiphyseal ossification (HP:0002663)1.92872806
96Limb-girdle muscle atrophy (HP:0003797)1.92771980
97Coronal craniosynostosis (HP:0004440)1.91338256
98Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.88787515
99Vertebral hypoplasia (HP:0008417)1.88787515
100Type 1 muscle fiber predominance (HP:0003803)1.88415091
101Short clavicles (HP:0000894)1.87852160
102Joint stiffness (HP:0001387)1.87592833
103Beaking of vertebral bodies (HP:0004568)1.87383364
104Entropion (HP:0000621)1.87151606
105Disproportionate tall stature (HP:0001519)1.87100343
106Alopecia of scalp (HP:0002293)1.86914950
107Abnormality of the umbilical cord (HP:0010881)1.86825268
108Abnormality of the 2nd finger (HP:0004100)1.86451340
109Stillbirth (HP:0003826)1.86072432
110Acanthosis nigricans (HP:0000956)1.85213520
111Limited elbow extension (HP:0001377)1.85035163
112Follicular hyperkeratosis (HP:0007502)1.83261795
113Femoral bowing (HP:0002980)1.82442501
114Down-sloping shoulders (HP:0200021)1.81989302
115Thoracolumbar scoliosis (HP:0002944)1.81943672
116Abnormal ossification of hand bones (HP:0005921)1.81768749
117Abnormal delivery (HP:0001787)1.81297587
118Long palpebral fissure (HP:0000637)1.81286061
119Osteoarthritis (HP:0002758)1.80802904
120Hyperextensible skin (HP:0000974)1.80800907
121Abnormality of oral frenula (HP:0000190)1.80769641
122Vitreoretinal degeneration (HP:0000655)1.80281205
123Myocardial infarction (HP:0001658)1.80099947
124Abnormality of the ischium (HP:0003174)1.78869690
125Deviation of the thumb (HP:0009603)1.78586990
126Bowed forearm bones (HP:0003956)1.78497250
127Bowing of the arm (HP:0006488)1.78497250
128Abnormality of carpal bone ossification (HP:0006257)1.78486131
129Aplasia/Hypoplasia of the clavicles (HP:0006710)1.78038696
130Mesomelia (HP:0003027)1.77547621
131Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.77246665
132Glossoptosis (HP:0000162)1.76976479
133Abnormality of skeletal muscle fiber size (HP:0012084)1.76475076
134Irregular epiphyses (HP:0010582)1.75492897
135Shoulder girdle muscle weakness (HP:0003547)1.75192842
136Delayed cranial suture closure (HP:0000270)1.74593581
137Increased variability in muscle fiber diameter (HP:0003557)1.74526541
138Pelvic girdle muscle weakness (HP:0003749)1.73657761
139Abnormalities of placenta or umbilical cord (HP:0001194)1.71066771
140Cerebral inclusion bodies (HP:0100314)1.69293069
141Interstitial pulmonary disease (HP:0006530)1.68997450
142Upper motor neuron abnormality (HP:0002127)1.68929262
143Long toe (HP:0010511)1.68644215
144Joint laxity (HP:0001388)1.67204514
145Limb-girdle muscle weakness (HP:0003325)1.65168878
146Breast hypoplasia (HP:0003187)1.63194611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.92157877
2MAP3K33.81912371
3IRAK33.79126733
4LATS22.93101923
5PIM22.79769240
6TESK12.75276462
7RPS6KA42.69784311
8LMTK22.66340431
9DDR22.65235581
10MOS2.53922772
11TRIB32.52573026
12ERN12.45460980
13BUB12.40918547
14LIMK12.35041918
15MST42.32209590
16NME22.26337922
17STK102.18596053
18TTN2.12638590
19LATS11.99464585
20TRPM71.97536087
21PAK21.94533527
22BMX1.91915768
23TAOK21.90900538
24MST1R1.80689175
25MAP3K111.78306385
26ICK1.77190546
27TAOK11.77057215
28FER1.68186237
29DMPK1.67043716
30LRRK21.65289476
31TESK21.57649306
32ARAF1.56803139
33PTK21.55243885
34ERBB31.54409968
35EPHB11.52020150
36PKN21.46461561
37VRK21.41869930
38MAPKAPK31.39950817
39EPHB21.35880200
40EPHA31.33477871
41RIPK11.32589271
42CDK81.30432658
43EEF2K1.28139019
44PTK61.27889110
45RPS6KB21.27086100
46MET1.25942761
47MYLK1.24432047
48MAP2K31.22750735
49NTRK11.20371613
50SMG11.12752792
51PDGFRA1.12580426
52TGFBR21.06532176
53MAPKAPK51.00201855
54MAP3K20.93848276
55PRKG20.91450358
56MAP3K80.90988694
57PRPF4B0.88836181
58SIK30.88742240
59STK380.85052636
60NEK10.84893768
61PTK2B0.84589982
62PRKD20.82550039
63FLT30.82313977
64TBK10.81333702
65MAP3K10.80454472
66MAP2K10.78311947
67BRSK10.76883636
68MKNK10.75671334
69ROCK10.74159091
70STK30.73166872
71PIK3CG0.72093377
72MAP3K120.72050971
73ILK0.71642100
74MAPKAPK20.71440083
75PAK40.68986081
76NEK20.68879581
77BRAF0.67871245
78PDGFRB0.67727479
79FGFR10.67359848
80IKBKB0.65900262
81CDK60.65737341
82KDR0.64747619
83PAK30.63847637
84CDK120.63754723
85MTOR0.62442006
86PAK10.60274635
87SIK10.59421556
88ALK0.58473363
89PAK60.57388070
90PBK0.57165064
91MAP3K50.56139607
92ABL20.55756228
93CHUK0.53763026
94FGFR40.53742994
95IRAK20.52168276
96PLK40.52088429
97PRKCI0.51809935
98STK38L0.51071618
99MAP3K140.50807237
100RPS6KA50.49484127
101ERBB40.49386753
102ROCK20.48270298
103FRK0.47476207
104CDK70.46980716
105MAP3K90.46607576
106DYRK1B0.45590865
107GSK3A0.44743834
108TGFBR10.44532562
109TSSK60.43944829
110NEK90.42930063
111INSR0.41413030
112DAPK10.40284870
113MELK0.38950576
114MAP3K60.38624972
115AURKB0.36929000
116PHKG10.36466700
117PHKG20.36466700
118ERBB20.35038420
119CSK0.34154113
120WEE10.33823804
121AURKA0.33270396
122PIM10.33262896
123MAP2K20.33034759
124PRKD10.32618545
125ABL10.31584162
126GRK70.31298693
127HIPK20.30902860
128EIF2AK20.29564085
129CHEK20.28143855
130HCK0.27967857
131PIK3CA0.27789376
132CDK90.27769547
133CDK140.27618332
134SCYL20.27139829
135PRKD30.26986959
136MAPK150.26875840
137PLK10.26805654
138CDK180.26764587
139CDK11A0.26339026
140EGFR0.24436146
141MAPK10.23528322
142EIF2AK10.23452651

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.18034452
2Bladder cancer_Homo sapiens_hsa052192.75576624
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.50085816
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.43192563
5Proteoglycans in cancer_Homo sapiens_hsa052052.41065566
6Proteasome_Homo sapiens_hsa030502.36364288
7Malaria_Homo sapiens_hsa051442.32600684
8Focal adhesion_Homo sapiens_hsa045102.28998023
9Ribosome_Homo sapiens_hsa030102.06129871
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.01755124
11Adherens junction_Homo sapiens_hsa045201.97886475
12MicroRNAs in cancer_Homo sapiens_hsa052061.94699619
13TNF signaling pathway_Homo sapiens_hsa046681.94585282
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.90430841
15p53 signaling pathway_Homo sapiens_hsa041151.87118491
16Small cell lung cancer_Homo sapiens_hsa052221.86784720
17Shigellosis_Homo sapiens_hsa051311.79589239
18TGF-beta signaling pathway_Homo sapiens_hsa043501.71321271
19DNA replication_Homo sapiens_hsa030301.69197314
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67231117
21Pyrimidine metabolism_Homo sapiens_hsa002401.61619484
22Pentose phosphate pathway_Homo sapiens_hsa000301.59922684
23Amoebiasis_Homo sapiens_hsa051461.56192707
24Hippo signaling pathway_Homo sapiens_hsa043901.53204886
25Sulfur relay system_Homo sapiens_hsa041221.52749872
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.50318644
27Galactose metabolism_Homo sapiens_hsa000521.50081349
28Chronic myeloid leukemia_Homo sapiens_hsa052201.48711553
29Apoptosis_Homo sapiens_hsa042101.42825406
30Biosynthesis of amino acids_Homo sapiens_hsa012301.38396718
31Fructose and mannose metabolism_Homo sapiens_hsa000511.38178337
32N-Glycan biosynthesis_Homo sapiens_hsa005101.35672217
33Nucleotide excision repair_Homo sapiens_hsa034201.35658521
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.33340303
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.31201840
36Cell cycle_Homo sapiens_hsa041101.30648509
37Salmonella infection_Homo sapiens_hsa051321.25246569
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.23211388
39Thyroid cancer_Homo sapiens_hsa052161.22413967
40Vibrio cholerae infection_Homo sapiens_hsa051101.20522643
41Legionellosis_Homo sapiens_hsa051341.19701380
42Protein digestion and absorption_Homo sapiens_hsa049741.17040719
43Viral myocarditis_Homo sapiens_hsa054161.16980271
44Dilated cardiomyopathy_Homo sapiens_hsa054141.16791268
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16564639
46Acute myeloid leukemia_Homo sapiens_hsa052211.15616325
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.15459042
48Prion diseases_Homo sapiens_hsa050201.14851496
49Toxoplasmosis_Homo sapiens_hsa051451.13910245
50Other glycan degradation_Homo sapiens_hsa005111.13713384
51* HTLV-I infection_Homo sapiens_hsa051661.12031623
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09485635
53HIF-1 signaling pathway_Homo sapiens_hsa040661.08141003
54VEGF signaling pathway_Homo sapiens_hsa043701.07537608
55Prostate cancer_Homo sapiens_hsa052151.07517906
56Melanoma_Homo sapiens_hsa052181.07453004
57Leishmaniasis_Homo sapiens_hsa051401.06865369
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05767024
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04673662
60Rap1 signaling pathway_Homo sapiens_hsa040151.02270110
61Tight junction_Homo sapiens_hsa045301.01050900
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98289071
63Hepatitis B_Homo sapiens_hsa051610.95736599
64Pancreatic cancer_Homo sapiens_hsa052120.95183085
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.95148146
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94507537
67Renal cell carcinoma_Homo sapiens_hsa052110.92634535
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91991456
69Hematopoietic cell lineage_Homo sapiens_hsa046400.91267885
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89746350
71Base excision repair_Homo sapiens_hsa034100.89353665
72Phagosome_Homo sapiens_hsa041450.87749929
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.86139942
74Viral carcinogenesis_Homo sapiens_hsa052030.86071491
75Pertussis_Homo sapiens_hsa051330.85791104
76Folate biosynthesis_Homo sapiens_hsa007900.85135562
77Platelet activation_Homo sapiens_hsa046110.84048066
78* Osteoclast differentiation_Homo sapiens_hsa043800.84021701
79Basal cell carcinoma_Homo sapiens_hsa052170.82952124
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.82779931
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82527349
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81869016
83Arachidonic acid metabolism_Homo sapiens_hsa005900.81560728
84Pathways in cancer_Homo sapiens_hsa052000.81501209
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.80962167
86ErbB signaling pathway_Homo sapiens_hsa040120.80291256
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80204587
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80041235
89RNA polymerase_Homo sapiens_hsa030200.78640996
90Glioma_Homo sapiens_hsa052140.77546528
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75948083
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.74712737
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74620444
94Sphingolipid metabolism_Homo sapiens_hsa006000.74109884
95Hedgehog signaling pathway_Homo sapiens_hsa043400.73510027
96Non-small cell lung cancer_Homo sapiens_hsa052230.72766298
97GnRH signaling pathway_Homo sapiens_hsa049120.72119696
98One carbon pool by folate_Homo sapiens_hsa006700.71144777
99MAPK signaling pathway_Homo sapiens_hsa040100.70963671
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69168022
101Endometrial cancer_Homo sapiens_hsa052130.68343261
102Ras signaling pathway_Homo sapiens_hsa040140.67060407
103Carbon metabolism_Homo sapiens_hsa012000.66607662
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66298220
105Axon guidance_Homo sapiens_hsa043600.65090008
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63764473
107Prolactin signaling pathway_Homo sapiens_hsa049170.63356880
108Epstein-Barr virus infection_Homo sapiens_hsa051690.63189076
109Glutathione metabolism_Homo sapiens_hsa004800.63120452
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62543223
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62493710
112Spliceosome_Homo sapiens_hsa030400.62030218
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61479532
114Lysosome_Homo sapiens_hsa041420.60195685
115FoxO signaling pathway_Homo sapiens_hsa040680.56701294
116Rheumatoid arthritis_Homo sapiens_hsa053230.56188977
117Estrogen signaling pathway_Homo sapiens_hsa049150.55761920
118Tuberculosis_Homo sapiens_hsa051520.55367385
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54813680
120Mismatch repair_Homo sapiens_hsa034300.54381722
121Gap junction_Homo sapiens_hsa045400.52609103
122RNA transport_Homo sapiens_hsa030130.52021259
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50848284
124Endocytosis_Homo sapiens_hsa041440.49443761
125Hepatitis C_Homo sapiens_hsa051600.49072449
126Influenza A_Homo sapiens_hsa051640.48177072
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.47671368
128Antigen processing and presentation_Homo sapiens_hsa046120.47180984
129Colorectal cancer_Homo sapiens_hsa052100.46535891
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.46212797
131Sulfur metabolism_Homo sapiens_hsa009200.45378796
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44766741
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44637429
134Insulin signaling pathway_Homo sapiens_hsa049100.44508063
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44444657
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44035724
137* Wnt signaling pathway_Homo sapiens_hsa043100.43882916
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43829579
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42117576

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