ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of guanylate cyclase activity (GO:0031284)	6.98486744
2	regulation of guanylate cyclase activity (GO:0031282)	6.27472999
3	peptidyl-arginine methylation (GO:0018216)	5.02699778
4	peptidyl-arginine N-methylation (GO:0035246)	5.02699778
5	purine ribonucleotide transport (GO:0015868)	4.57989145
6	iron-sulfur cluster assembly (GO:0016226)	4.57982865
7	metallo-sulfur cluster assembly (GO:0031163)	4.57982865
8	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.52479350
9	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.52479350
10	respiratory chain complex IV assembly (GO:0008535)	4.42294616
11	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	4.32361679
12	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.29979379
13	cerebral cortex neuron differentiation (GO:0021895)	4.23925252
14	glucosamine-containing compound catabolic process (GO:1901072)	4.21581600
15	positive regulation of cGMP biosynthetic process (GO:0030828)	4.20928907
16	adenine nucleotide transport (GO:0051503)	4.19296078
17	cellular ketone body metabolic process (GO:0046950)	4.14589299
18	prenylation (GO:0097354)	4.05722064
19	protein prenylation (GO:0018342)	4.05722064
20	lung secretory cell differentiation (GO:0061140)	3.91591117
21	regulation of cGMP biosynthetic process (GO:0030826)	3.90686428
22	base-excision repair, AP site formation (GO:0006285)	3.87882571
23	forebrain neuron differentiation (GO:0021879)	3.86443550
24	regulation of development, heterochronic (GO:0040034)	3.71996088
25	spinal cord association neuron differentiation (GO:0021527)	3.71740112
26	ketone body metabolic process (GO:1902224)	3.69190343
27	positive regulation of cGMP metabolic process (GO:0030825)	3.65089378
28	regulation of mitochondrial translation (GO:0070129)	3.64351775
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.63714118
30	NADH dehydrogenase complex assembly (GO:0010257)	3.63714118
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.63714118
32	cullin deneddylation (GO:0010388)	3.59593381
33	positive regulation of prostaglandin secretion (GO:0032308)	3.59342777
34	short-term memory (GO:0007614)	3.57542022
35	cytochrome complex assembly (GO:0017004)	3.53919815
36	positive regulation of protein kinase C signaling (GO:0090037)	3.53148914
37	platelet dense granule organization (GO:0060155)	3.53023867
38	regulation of timing of cell differentiation (GO:0048505)	3.52892074
39	regulation of cGMP metabolic process (GO:0030823)	3.47829921
40	regulation of cilium movement (GO:0003352)	3.45733605
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.43938633
42	signal peptide processing (GO:0006465)	3.36313595
43	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.34771586
44	regulation of hydrogen peroxide metabolic process (GO:0010310)	3.32187134
45	protein complex biogenesis (GO:0070271)	3.31698091
46	ATP synthesis coupled proton transport (GO:0015986)	3.30894308
47	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.30894308
48	GPI anchor biosynthetic process (GO:0006506)	3.28564140
49	protein deneddylation (GO:0000338)	3.27652753
50	guanosine-containing compound biosynthetic process (GO:1901070)	3.24295789
51	purine nucleotide transport (GO:0015865)	3.19381850
52	deoxyribonucleotide catabolic process (GO:0009264)	3.19327417
53	mitochondrial respiratory chain complex assembly (GO:0033108)	3.15846379
54	GTP biosynthetic process (GO:0006183)	3.14382367
55	cysteine metabolic process (GO:0006534)	3.11513979
56	glycolipid biosynthetic process (GO:0009247)	3.11069667
57	positive regulation of fatty acid transport (GO:2000193)	3.11056288
58	glycosphingolipid biosynthetic process (GO:0006688)	3.09173921
59	nucleoside transport (GO:0015858)	3.07952950
60	dermatan sulfate metabolic process (GO:0030205)	3.04415704
61	pyrimidine nucleotide catabolic process (GO:0006244)	3.01730809
62	nucleotide transport (GO:0006862)	2.98311357
63	positive regulation of icosanoid secretion (GO:0032305)	2.97227469
64	GPI anchor metabolic process (GO:0006505)	2.97164895
65	deoxyribose phosphate catabolic process (GO:0046386)	2.96859710
66	histone H2A acetylation (GO:0043968)	2.96219896
67	heme metabolic process (GO:0042168)	2.95251739
68	galactose catabolic process (GO:0019388)	2.93879432
69	sequestering of actin monomers (GO:0042989)	2.92599460
70	respiratory electron transport chain (GO:0022904)	2.92411934
71	branched-chain amino acid catabolic process (GO:0009083)	2.88352649
72	nucleotide transmembrane transport (GO:1901679)	2.87817360
73	electron transport chain (GO:0022900)	2.87393986
74	GMP metabolic process (GO:0046037)	2.87222872
75	peptidyl-arginine modification (GO:0018195)	2.86633135
76	regulation of prostaglandin secretion (GO:0032306)	2.86115887
77	nonribosomal peptide biosynthetic process (GO:0019184)	2.85749717
78	dermatan sulfate biosynthetic process (GO:0030208)	2.83034472
79	glutathione biosynthetic process (GO:0006750)	2.82953822
80	positive regulation of Notch signaling pathway (GO:0045747)	2.82775543
81	fatty acid elongation (GO:0030497)	2.81118175
82	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.79343651
83	nephron epithelium morphogenesis (GO:0072088)	2.78827229
84	nephron tubule morphogenesis (GO:0072078)	2.78827229
85	GDP-mannose metabolic process (GO:0019673)	2.76977790
86	centriole replication (GO:0007099)	2.76538201
87	adenosine metabolic process (GO:0046085)	2.74107354
88	positive regulation of mitochondrial fission (GO:0090141)	2.73347609
89	aggressive behavior (GO:0002118)	2.70663798
90	amino sugar catabolic process (GO:0046348)	2.68439508
91	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.66191627
92	detection of molecule of bacterial origin (GO:0032490)	2.65406591
93	head development (GO:0060322)	2.64730589
94	oxidative phosphorylation (GO:0006119)	2.63246686
95	norepinephrine metabolic process (GO:0042415)	2.62981208
96	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.61516209
97	response to gravity (GO:0009629)	2.60674640
98	UTP metabolic process (GO:0046051)	2.60178641
99	sodium-independent organic anion transport (GO:0043252)	2.59897180
100	positive regulation of insulin receptor signaling pathway (GO:0046628)	2.57363738

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	6.41272962
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.83527728
3	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	3.75326681
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.69371048
5	IGF1R_20145208_ChIP-Seq_DFB_Human	3.63891434
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.51744702
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.44720807
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.36847440
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.17854726
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.10089195
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.03429485
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.78866265
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.73726713
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.59712385
15	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.49987784
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.45801190
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.23676153
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.21618255
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.20999612
20	CBP_20019798_ChIP-Seq_JUKART_Human	2.00338897
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.00338897
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.93894630
23	GATA1_22025678_ChIP-Seq_K562_Human	1.84196615
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.80439257
25	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.76143157
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.73979493
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.67829611
28	GABP_19822575_ChIP-Seq_HepG2_Human	1.67190527
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.61696860
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.54438583
31	EWS_26573619_Chip-Seq_HEK293_Human	1.48828215
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46202810
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.44272310
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.43129634
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.39207603
36	HTT_18923047_ChIP-ChIP_STHdh_Human	1.38050030
37	P300_19829295_ChIP-Seq_ESCs_Human	1.33225849
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32795932
39	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.31575502
40	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.29327640
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29003280
42	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.28591791
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.27194197
44	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25682276
45	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25331441
46	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.24060325
47	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.21418461
48	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.20224353
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20212755
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20212755
51	ERA_21632823_ChIP-Seq_H3396_Human	1.18976240
52	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16797928
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.15975962
54	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.11464624
55	VDR_22108803_ChIP-Seq_LS180_Human	1.11281832
56	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10524720
57	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10123467
58	TTF2_22483619_ChIP-Seq_HELA_Human	1.09285559
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05840484
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05260877
61	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.03945550
62	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.03852898
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.02152925
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00493734
65	FOXP3_21729870_ChIP-Seq_TREG_Human	0.99999840
66	AR_20517297_ChIP-Seq_VCAP_Human	0.98805083
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.97298396
68	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96892910
69	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96554708
70	OCT4_20526341_ChIP-Seq_ESCs_Human	0.95407671
71	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.94764587
72	MYC_19829295_ChIP-Seq_ESCs_Human	0.93157005
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91915617
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.91210349
75	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.91142380
76	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.90583943
77	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.89899700
78	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.89342956
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.88644218
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.88137718
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.88137718
82	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.87967386
83	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.87649509
84	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.87575842
85	HOXB7_26014856_ChIP-Seq_BT474_Human	0.85538658
86	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.85122735
87	RNF2_27304074_Chip-Seq_NSC_Mouse	0.84644523
88	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.82725972
89	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.81535114
90	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.80719051
91	MYC_18940864_ChIP-ChIP_HL60_Human	0.80216560
92	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.79784288
93	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.79654298
94	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.79211903
95	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.79121063
96	NCOR_22424771_ChIP-Seq_293T_Human	0.78330447
97	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.78137693
98	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.77902697
99	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.77299482
100	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.77023654

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.61198875
2	MP0002139_abnormal_hepatobiliary_system	3.34915903
3	MP0003880_abnormal_central_pattern	3.29693273
4	MP0003136_yellow_coat_color	3.26822335
5	MP0008995_early_reproductive_senescence	3.14049336
6	MP0003183_abnormal_peptide_metabolism	3.01854069
7	MP0005645_abnormal_hypothalamus_physiol	2.85985059
8	MP0001485_abnormal_pinna_reflex	2.71163659
9	MP0008004_abnormal_stomach_pH	2.58160135
10	MP0005174_abnormal_tail_pigmentation	2.46365781
11	MP0002234_abnormal_pharynx_morphology	2.42431241
12	MP0004885_abnormal_endolymph	2.31009079
13	MP0001764_abnormal_homeostasis	2.30639296
14	MP0008789_abnormal_olfactory_epithelium	2.30156392
15	MP0000013_abnormal_adipose_tissue	2.29584959
16	MP0005646_abnormal_pituitary_gland	2.17141054
17	MP0000049_abnormal_middle_ear	2.11232358
18	MP0005394_taste/olfaction_phenotype	2.04949246
19	MP0005499_abnormal_olfactory_system	2.04949246
20	MP0001849_ear_inflammation	2.03740466
21	MP0006292_abnormal_olfactory_placode	2.03527699
22	MP0009697_abnormal_copulation	2.00904940
23	MP0000569_abnormal_digit_pigmentation	2.00875013
24	MP0003656_abnormal_erythrocyte_physiolo	1.99664387
25	MP0004133_heterotaxia	1.86586529
26	MP0000681_abnormal_thyroid_gland	1.85472450
27	MP0002837_dystrophic_cardiac_calcinosis	1.84393006
28	MP0005551_abnormal_eye_electrophysiolog	1.73022657
29	MP0003195_calcinosis	1.71401845
30	MP0002282_abnormal_trachea_morphology	1.71116351
31	MP0002638_abnormal_pupillary_reflex	1.66822210
32	MP0002249_abnormal_larynx_morphology	1.59807010
33	MP0006072_abnormal_retinal_apoptosis	1.58654030
34	MP0001545_abnormal_hematopoietic_system	1.58295018
35	MP0005397_hematopoietic_system_phenotyp	1.58295018
36	MP0001968_abnormal_touch/_nociception	1.52659282
37	MP0000015_abnormal_ear_pigmentation	1.50957035
38	MP0003119_abnormal_digestive_system	1.46061847
39	MP0001984_abnormal_olfaction	1.42084646
40	MP0003718_maternal_effect	1.38746543
41	MP0002277_abnormal_respiratory_mucosa	1.38471721
42	MP0003806_abnormal_nucleotide_metabolis	1.37397710
43	MP0003221_abnormal_cardiomyocyte_apopto	1.34288465
44	MP0005647_abnormal_sex_gland	1.32217574
45	MP0008058_abnormal_DNA_repair	1.31901994
46	MP0002736_abnormal_nociception_after	1.27292554
47	MP0002233_abnormal_nose_morphology	1.24945236
48	MP0002177_abnormal_outer_ear	1.22571892
49	MP0002095_abnormal_skin_pigmentation	1.22068971
50	MP0003938_abnormal_ear_development	1.21527023
51	MP0004381_abnormal_hair_follicle	1.21053731
52	MP0003172_abnormal_lysosome_physiology	1.20759166
53	MP0008961_abnormal_basal_metabolism	1.18920780
54	MP0000003_abnormal_adipose_tissue	1.18034859
55	MP0009278_abnormal_bone_marrow	1.13727976
56	MP0005670_abnormal_white_adipose	1.11009054
57	MP0003191_abnormal_cellular_cholesterol	1.10718577
58	MP0002332_abnormal_exercise_endurance	1.10622736
59	MP0002751_abnormal_autonomic_nervous	1.09739150
60	MP0002653_abnormal_ependyma_morphology	1.07379554
61	MP0000026_abnormal_inner_ear	1.06733387
62	MP0008875_abnormal_xenobiotic_pharmacok	1.05303690
63	MP0005253_abnormal_eye_physiology	1.05144617
64	MP0001905_abnormal_dopamine_level	1.05030224
65	MP0000639_abnormal_adrenal_gland	1.03276360
66	MP0001664_abnormal_digestion	1.02027868
67	MP0010678_abnormal_skin_adnexa	0.99443207
68	MP0002163_abnormal_gland_morphology	0.98148481
69	MP0000383_abnormal_hair_follicle	0.97061388
70	MP0005360_urolithiasis	0.96698290
71	MP0003252_abnormal_bile_duct	0.96361336
72	MP0006036_abnormal_mitochondrial_physio	0.96116245
73	MP0000631_abnormal_neuroendocrine_gland	0.94431103
74	MP0002090_abnormal_vision	0.87185073
75	MP0005266_abnormal_metabolism	0.85881688
76	MP0005167_abnormal_blood-brain_barrier	0.85504580
77	MP0005084_abnormal_gallbladder_morpholo	0.82921762
78	MP0000358_abnormal_cell_content/	0.82522619
79	MP0005075_abnormal_melanosome_morpholog	0.80775589
80	MP0005376_homeostasis/metabolism_phenot	0.79215997
81	MP0005332_abnormal_amino_acid	0.77834803
82	MP0001963_abnormal_hearing_physiology	0.76779864
83	MP0003122_maternal_imprinting	0.76088068
84	MP0000647_abnormal_sebaceous_gland	0.75225375
85	MP0002909_abnormal_adrenal_gland	0.72128184
86	MP0003890_abnormal_embryonic-extraembry	0.70391022
87	MP0008057_abnormal_DNA_replication	0.65686732
88	MP0001286_abnormal_eye_development	0.65010051
89	MP0000467_abnormal_esophagus_morphology	0.64910248
90	MP0002132_abnormal_respiratory_system	0.63934419
91	MP0008872_abnormal_physiological_respon	0.63265044
92	MP0003638_abnormal_response/metabolism_	0.62809585
93	MP0001970_abnormal_pain_threshold	0.61870929
94	MP0001529_abnormal_vocalization	0.61291924
95	MP0005584_abnormal_enzyme/coenzyme_acti	0.60322204
96	MP0005085_abnormal_gallbladder_physiolo	0.59027834
97	MP0003121_genomic_imprinting	0.58896749
98	MP0002752_abnormal_somatic_nervous	0.58890433
99	MP0002254_reproductive_system_inflammat	0.58114618
100	MP0001340_abnormal_eyelid_morphology	0.57054092

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Thyroid-stimulating hormone excess (HP:0002925)	5.42339308
2	Carpal bone hypoplasia (HP:0001498)	4.88594798
3	J-shaped sella turcica (HP:0002680)	4.54472298
4	Intestinal atresia (HP:0011100)	4.22229353
5	Reduced antithrombin III activity (HP:0001976)	4.08161162
6	Type I transferrin isoform profile (HP:0003642)	3.77426745
7	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.67289020
8	Neonatal respiratory distress (HP:0002643)	3.62818557
9	Tubulointerstitial nephritis (HP:0001970)	3.43578750
10	Hepatocellular necrosis (HP:0001404)	3.38230244
11	Abnormal number of erythroid precursors (HP:0012131)	3.25917098
12	Vertebral arch anomaly (HP:0008438)	3.25188826
13	Acute necrotizing encephalopathy (HP:0006965)	3.21883443
14	Hepatic necrosis (HP:0002605)	3.21424468
15	Deformed sella turcica (HP:0002681)	3.20410129
16	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.19186751
17	Abnormal protein N-linked glycosylation (HP:0012347)	3.19186751
18	Abnormal protein glycosylation (HP:0012346)	3.19186751
19	Abnormal glycosylation (HP:0012345)	3.19186751
20	Mitochondrial inheritance (HP:0001427)	3.18924984
21	Acute encephalopathy (HP:0006846)	3.15565378
22	Increased CSF lactate (HP:0002490)	3.04257977
23	Abnormality of glycolipid metabolism (HP:0010969)	2.93978171
24	Abnormality of liposaccharide metabolism (HP:0010968)	2.93978171
25	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.93978171
26	Epidermoid cyst (HP:0200040)	2.75724761
27	Abnormal mitochondria in muscle tissue (HP:0008316)	2.68410357
28	Progressive microcephaly (HP:0000253)	2.68189578
29	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.60623297
30	Gonadotropin excess (HP:0000837)	2.58589309
31	Progressive macrocephaly (HP:0004481)	2.57994513
32	Chronic hepatic failure (HP:0100626)	2.46948422
33	Microvesicular hepatic steatosis (HP:0001414)	2.46025265
34	Hyperglycinemia (HP:0002154)	2.45563226
35	3-Methylglutaconic aciduria (HP:0003535)	2.44744197
36	Nephronophthisis (HP:0000090)	2.44591060
37	Hyperpituitarism (HP:0010514)	2.44524014
38	Ependymoma (HP:0002888)	2.43994783
39	Thoracolumbar scoliosis (HP:0002944)	2.43376769
40	Albinism (HP:0001022)	2.42686612
41	Increased serum pyruvate (HP:0003542)	2.41908210
42	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.41297733
43	Polyphagia (HP:0002591)	2.40784162
44	Progressive inability to walk (HP:0002505)	2.33350976
45	Abnormality of cells of the erythroid lineage (HP:0012130)	2.31302890
46	Aortic regurgitation (HP:0001659)	2.30700163
47	Cerebral edema (HP:0002181)	2.29537948
48	Gout (HP:0001997)	2.27453116
49	Pancreatic fibrosis (HP:0100732)	2.26923582
50	Pancreatic cysts (HP:0001737)	2.26763583
51	True hermaphroditism (HP:0010459)	2.23942536
52	Thoracic kyphosis (HP:0002942)	2.19996723
53	Abnormality of the sella turcica (HP:0002679)	2.19598866
54	Renal Fanconi syndrome (HP:0001994)	2.15018564
55	Opisthotonus (HP:0002179)	2.13050992
56	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.10302196
57	Absent epiphyses (HP:0010577)	2.10302196
58	Abnormality of glycolysis (HP:0004366)	2.10261991
59	Lactic acidosis (HP:0003128)	2.08751264
60	Tubular atrophy (HP:0000092)	2.06322772
61	Long nose (HP:0003189)	2.04688334
62	Spastic tetraparesis (HP:0001285)	2.02115019
63	Broad distal phalanx of finger (HP:0009836)	2.01743819
64	Gastrointestinal atresia (HP:0002589)	1.98535724
65	Glioma (HP:0009733)	1.90652927
66	Renal cortical cysts (HP:0000803)	1.89882771
67	Diastasis recti (HP:0001540)	1.88768691
68	Respiratory distress (HP:0002098)	1.88087761
69	Occipital encephalocele (HP:0002085)	1.87257105
70	Cerebral palsy (HP:0100021)	1.86696122
71	Abnormality of alanine metabolism (HP:0010916)	1.84851305
72	Hyperalaninemia (HP:0003348)	1.84851305
73	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84851305
74	Attenuation of retinal blood vessels (HP:0007843)	1.84755356
75	Increased serum lactate (HP:0002151)	1.84336531
76	Gait imbalance (HP:0002141)	1.82696217
77	Dicarboxylic aciduria (HP:0003215)	1.81062664
78	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.81062664
79	Nephrogenic diabetes insipidus (HP:0009806)	1.79896575
80	Respiratory failure (HP:0002878)	1.77751544
81	Optic disc pallor (HP:0000543)	1.77237035
82	Congenital primary aphakia (HP:0007707)	1.77097037
83	Inability to walk (HP:0002540)	1.76310938
84	Abnormality of the astrocytes (HP:0100707)	1.75724190
85	Astrocytoma (HP:0009592)	1.75724190
86	Vitreoretinal degeneration (HP:0000655)	1.75532895
87	Abolished electroretinogram (ERG) (HP:0000550)	1.74738131
88	Ketosis (HP:0001946)	1.74656982
89	Congenital hepatic fibrosis (HP:0002612)	1.74170127
90	Medial flaring of the eyebrow (HP:0010747)	1.73798281
91	Molar tooth sign on MRI (HP:0002419)	1.72806610
92	Abnormality of midbrain morphology (HP:0002418)	1.72806610
93	Lethargy (HP:0001254)	1.72592958
94	Abnormality of the renal medulla (HP:0100957)	1.72188608
95	Sleep apnea (HP:0010535)	1.71669517
96	Neoplasm of the heart (HP:0100544)	1.71550350
97	Short 1st metacarpal (HP:0010034)	1.70791981
98	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	1.70791981
99	Hypoplasia of the pons (HP:0012110)	1.69104502
100	Abnormal biliary tract physiology (HP:0012439)	1.68293074

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	7.96221035
2	BCKDK	3.94591252
3	MAP3K6	3.28873182
4	VRK2	3.08196932
5	BCR	2.96229023
6	BMPR1B	2.90973252
7	TIE1	2.58871894
8	MAP4K2	2.51912026
9	TRIM28	2.42073481
10	MAP2K3	2.40431566
11	KDR	2.36220109
12	MUSK	2.30396468
13	MAP2K6	2.25054585
14	WNK4	2.17838324
15	MINK1	2.03635602
16	SRPK1	1.99157615
17	VRK1	1.52206366
18	MST4	1.50130771
19	PINK1	1.45015436
20	PIM2	1.40470050
21	ACVR1B	1.37662355
22	NUAK1	1.32312744
23	TNIK	1.26257642
24	RPS6KA4	1.24842996
25	PDK2	1.21855769
26	CSNK1G3	1.17669792
27	EIF2AK1	1.16860993
28	PBK	1.14386605
29	MATK	1.14364466
30	PKN2	1.13783037
31	ADRBK1	1.11334572
32	TGFBR1	1.04020088
33	MAP2K4	1.02795255
34	CSNK1A1L	1.00697831
35	FRK	0.98184914
36	CSNK1G2	0.96902442
37	FLT3	0.96022172
38	ADRBK2	0.95598081
39	MST1R	0.90574057
40	ERBB2	0.87117628
41	CSNK1G1	0.84981487
42	SIK3	0.83716980
43	WNK3	0.81294320
44	EPHA4	0.78853515
45	NME2	0.77282653
46	NTRK2	0.75729320
47	NME1	0.73190143
48	DYRK2	0.72821214
49	GRK1	0.72613117
50	CDK19	0.66583067
51	OXSR1	0.65937458
52	BMX	0.64968959
53	DYRK3	0.62266534
54	NEK9	0.58716914
55	PHKG1	0.57314242
56	PHKG2	0.57314242
57	MAPK13	0.56984152
58	ZAK	0.54789797
59	STK38	0.52125826
60	BLK	0.51547087
61	ABL2	0.50663775
62	PRKCE	0.48592289
63	DAPK2	0.44127254
64	NEK2	0.43989714
65	TESK1	0.41859933
66	EPHA2	0.39709106
67	PRKCI	0.39359771
68	TLK1	0.39024622
69	MAP2K7	0.37428833
70	CCNB1	0.36743555
71	CSNK1A1	0.35295435
72	TNK2	0.34917729
73	ZAP70	0.33689671
74	PRKD3	0.33285699
75	ATR	0.32940175
76	RAF1	0.32431807
77	PRKG1	0.32126213
78	PTK2B	0.29594593
79	CSNK2A1	0.29475459
80	MET	0.29161961
81	DAPK1	0.28404336
82	MKNK1	0.25314155
83	RET	0.24640490
84	FER	0.24164510
85	NTRK3	0.24064462
86	PLK3	0.23772734
87	TBK1	0.23582543
88	CAMK2A	0.22950587
89	PAK4	0.21725292
90	LRRK2	0.21462478
91	RPS6KA5	0.20447331
92	RPS6KA6	0.18729695
93	AURKB	0.18522622
94	CSNK2A2	0.17426257
95	CHUK	0.17361494
96	PKN1	0.17153283
97	PRKACA	0.16988773
98	EGFR	0.16755059
99	MAP3K5	0.16531032
100	IRAK1	0.16460768

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.66406846
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.41245471
3	Phototransduction_Homo sapiens_hsa04744	3.16224957
4	Parkinsons disease_Homo sapiens_hsa05012	3.05983245
5	Protein export_Homo sapiens_hsa03060	2.78393763
6	Butanoate metabolism_Homo sapiens_hsa00650	2.36111653
7	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.32908602
8	Proteasome_Homo sapiens_hsa03050	2.26174344
9	Huntingtons disease_Homo sapiens_hsa05016	2.20006524
10	Sulfur relay system_Homo sapiens_hsa04122	2.12469078
11	Alzheimers disease_Homo sapiens_hsa05010	1.88348514
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86863001
13	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.84778585
14	Base excision repair_Homo sapiens_hsa03410	1.82370338
15	RNA polymerase_Homo sapiens_hsa03020	1.80610709
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.78065071
17	Fatty acid elongation_Homo sapiens_hsa00062	1.77830361
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76039173
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.72230734
20	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.67998585
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62861703
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.62306042
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.58504993
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.58096614
25	Homologous recombination_Homo sapiens_hsa03440	1.57842732
26	Mismatch repair_Homo sapiens_hsa03430	1.49300173
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.42002493
28	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.40643717
29	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.39990306
30	Glutathione metabolism_Homo sapiens_hsa00480	1.38636580
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37052748
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34415556
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.33633182
34	Peroxisome_Homo sapiens_hsa04146	1.33586000
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.31697216
36	Folate biosynthesis_Homo sapiens_hsa00790	1.29811471
37	Basal transcription factors_Homo sapiens_hsa03022	1.21372220
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.19619970
39	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.19519710
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.18172484
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.17185651
42	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13365243
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.10724823
44	Steroid biosynthesis_Homo sapiens_hsa00100	1.08508566
45	Purine metabolism_Homo sapiens_hsa00230	1.01073590
46	RNA degradation_Homo sapiens_hsa03018	1.00816526
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96371712
48	Metabolic pathways_Homo sapiens_hsa01100	0.93452224
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92624594
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.90360996
51	Spliceosome_Homo sapiens_hsa03040	0.89383401
52	Sulfur metabolism_Homo sapiens_hsa00920	0.86634789
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.86100012
54	DNA replication_Homo sapiens_hsa03030	0.84963699
55	Non-homologous end-joining_Homo sapiens_hsa03450	0.84857747
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81130076
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80454417
58	Propanoate metabolism_Homo sapiens_hsa00640	0.78688688
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78566257
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75964260
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75664009
62	Galactose metabolism_Homo sapiens_hsa00052	0.73967571
63	ABC transporters_Homo sapiens_hsa02010	0.72056592
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71547497
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70306660
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68131944
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67283731
68	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.64371701
69	Nicotine addiction_Homo sapiens_hsa05033	0.62247195
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.61271200
71	One carbon pool by folate_Homo sapiens_hsa00670	0.61068976
72	Oocyte meiosis_Homo sapiens_hsa04114	0.60680245
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.59512378
74	Notch signaling pathway_Homo sapiens_hsa04330	0.58293281
75	Retinol metabolism_Homo sapiens_hsa00830	0.56790449
76	Ribosome_Homo sapiens_hsa03010	0.56145128
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.54801418
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52973597
79	Insulin secretion_Homo sapiens_hsa04911	0.47872394
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.46788142
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.44723317
82	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44218301
83	Renin-angiotensin system_Homo sapiens_hsa04614	0.43956353
84	Taste transduction_Homo sapiens_hsa04742	0.43886861
85	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.42684863
86	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37726367
87	RNA transport_Homo sapiens_hsa03013	0.37351871
88	Other glycan degradation_Homo sapiens_hsa00511	0.36339114
89	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.35681225
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.33945887
91	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.33001859
92	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.32333272
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27717392
94	Tryptophan metabolism_Homo sapiens_hsa00380	0.27448467
95	Fat digestion and absorption_Homo sapiens_hsa04975	0.26568277
96	GABAergic synapse_Homo sapiens_hsa04727	0.25679745
97	Salivary secretion_Homo sapiens_hsa04970	0.24780268
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.24660579
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.19549783
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.18842538

FOSL1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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