FOXA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.02379700
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.02379700
3L-phenylalanine metabolic process (GO:0006558)6.71403039
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.71403039
5aromatic amino acid family catabolic process (GO:0009074)5.64637353
6COPI coating of Golgi vesicle (GO:0048205)5.57814613
7Golgi transport vesicle coating (GO:0048200)5.57814613
8* endocrine pancreas development (GO:0031018)4.97092011
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.74088453
10negative regulation of fibrinolysis (GO:0051918)4.52215542
11regulation of fibrinolysis (GO:0051917)4.48501462
12tryptophan metabolic process (GO:0006568)4.48275382
13sulfur amino acid catabolic process (GO:0000098)4.48077290
14glyoxylate metabolic process (GO:0046487)4.46853856
15indole-containing compound catabolic process (GO:0042436)4.46776382
16indolalkylamine catabolic process (GO:0046218)4.46776382
17tryptophan catabolic process (GO:0006569)4.46776382
18nephron epithelium morphogenesis (GO:0072088)4.46293959
19nephron tubule morphogenesis (GO:0072078)4.46293959
20tyrosine metabolic process (GO:0006570)4.45674738
21bile acid biosynthetic process (GO:0006699)4.44776020
22peptidyl-glutamic acid carboxylation (GO:0017187)4.41931562
23protein carboxylation (GO:0018214)4.41931562
24kynurenine metabolic process (GO:0070189)4.35224250
25high-density lipoprotein particle remodeling (GO:0034375)4.32719939
26alpha-linolenic acid metabolic process (GO:0036109)4.31169629
27intestinal cholesterol absorption (GO:0030299)4.29273442
28midbrain development (GO:0030901)4.28870891
29aromatic amino acid family metabolic process (GO:0009072)4.21876327
30COPII vesicle coating (GO:0048208)4.19850058
31cysteine metabolic process (GO:0006534)4.12473708
32dopamine biosynthetic process (GO:0042416)4.09873428
33hindbrain development (GO:0030902)4.09191979
34acylglycerol homeostasis (GO:0055090)4.08214579
35triglyceride homeostasis (GO:0070328)4.08214579
36bile acid metabolic process (GO:0008206)4.05414942
37glandular epithelial cell differentiation (GO:0002067)4.04595183
38urea metabolic process (GO:0019627)4.03354802
39urea cycle (GO:0000050)4.03354802
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.01055943
41reverse cholesterol transport (GO:0043691)3.94939426
42complement activation, alternative pathway (GO:0006957)3.94580074
43negative regulation of cholesterol transport (GO:0032375)3.90356086
44negative regulation of sterol transport (GO:0032372)3.90356086
45regulation of protein activation cascade (GO:2000257)3.88126053
46* dopaminergic neuron differentiation (GO:0071542)3.82989891
47bile acid and bile salt transport (GO:0015721)3.78249411
48cellular ketone body metabolic process (GO:0046950)3.76809153
49protein retention in ER lumen (GO:0006621)3.76766199
50lysine metabolic process (GO:0006553)3.76572586
51lysine catabolic process (GO:0006554)3.76572586
52nitrogen cycle metabolic process (GO:0071941)3.73656187
53regulation of cholesterol esterification (GO:0010872)3.66707317
54indolalkylamine metabolic process (GO:0006586)3.65855817
55homocysteine metabolic process (GO:0050667)3.64100517
56serine family amino acid catabolic process (GO:0009071)3.60759471
57regulation of complement activation (GO:0030449)3.57341447
58lung epithelium development (GO:0060428)3.56841070
59plasma lipoprotein particle remodeling (GO:0034369)3.56719654
60protein-lipid complex remodeling (GO:0034368)3.56719654
61macromolecular complex remodeling (GO:0034367)3.56719654
62imidazole-containing compound metabolic process (GO:0052803)3.55245581
63coenzyme catabolic process (GO:0009109)3.53636442
64regulation of cholesterol homeostasis (GO:2000188)3.53391100
65phospholipid efflux (GO:0033700)3.53180540
66alpha-amino acid catabolic process (GO:1901606)3.53065406
67neuron fate determination (GO:0048664)3.52580666
68intestinal absorption (GO:0050892)3.51542436
69behavioral response to nicotine (GO:0035095)3.51304207
70exocrine pancreas development (GO:0031017)3.49121116
714-hydroxyproline metabolic process (GO:0019471)3.48606176
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44575620
73peptide hormone processing (GO:0016486)3.41647196
74regulation of triglyceride catabolic process (GO:0010896)3.38127933
75cellular modified amino acid catabolic process (GO:0042219)3.36231137
76negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.35963798
77cellular amino acid catabolic process (GO:0009063)3.33205599
78renal tubule morphogenesis (GO:0061333)3.30683487
79cholesterol efflux (GO:0033344)3.29903304
80catechol-containing compound biosynthetic process (GO:0009713)3.29123277
81catecholamine biosynthetic process (GO:0042423)3.29123277
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28676730
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27365231
84lipoprotein metabolic process (GO:0042157)3.24267243
85ketone body metabolic process (GO:1902224)3.21910735
86* regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.20926631
87plasma lipoprotein particle clearance (GO:0034381)3.19138315
88retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18437978
89plasma lipoprotein particle assembly (GO:0034377)3.18293325
90kidney morphogenesis (GO:0060993)3.17396185
91positive regulation of glycolytic process (GO:0045821)3.16989086
92limb bud formation (GO:0060174)3.16519602
93regulation of bile acid biosynthetic process (GO:0070857)3.14764079
94benzene-containing compound metabolic process (GO:0042537)3.12895445
95amino-acid betaine metabolic process (GO:0006577)3.10072790
96positive regulation of fatty acid biosynthetic process (GO:0045723)3.09099038
97alkaloid metabolic process (GO:0009820)3.08945845
98type B pancreatic cell development (GO:0003323)3.08381054
99aldehyde catabolic process (GO:0046185)3.07964855
100epithelial cell fate commitment (GO:0072148)3.07487941
101embryonic retina morphogenesis in camera-type eye (GO:0060059)3.07024607
102amine catabolic process (GO:0009310)3.06733761
103cellular biogenic amine catabolic process (GO:0042402)3.06733761
104embryonic foregut morphogenesis (GO:0048617)3.04354716
105cell proliferation involved in metanephros development (GO:0072203)3.04146277
106glutamate metabolic process (GO:0006536)3.03303493
107establishment of protein localization to mitochondrial membrane (GO:0090151)3.03087216
108carboxylic acid catabolic process (GO:0046395)2.99691777
109organic acid catabolic process (GO:0016054)2.99691777
110macroautophagy (GO:0016236)2.98553516
111cell proliferation involved in kidney development (GO:0072111)2.98008561
112drug transmembrane transport (GO:0006855)2.97277034
113fibrinolysis (GO:0042730)2.97064205
114sequestering of actin monomers (GO:0042989)2.96438751
115glycerophospholipid catabolic process (GO:0046475)2.95162654
116cellular glucuronidation (GO:0052695)2.94807637
117drug metabolic process (GO:0017144)2.94535572
118positive regulation of insulin secretion (GO:0032024)2.94390780
119peristalsis (GO:0030432)2.93543291
120negative regulation of lipase activity (GO:0060192)2.91812625
121purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.91759411
1223-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.91759411
123glycine metabolic process (GO:0006544)2.91564413
124drug catabolic process (GO:0042737)2.89853487
125regulation of type B pancreatic cell apoptotic process (GO:2000674)2.89594764
126pyrimidine nucleoside catabolic process (GO:0046135)2.88646494
127blood coagulation, intrinsic pathway (GO:0007597)2.88376654
128regulation of mesenchymal cell apoptotic process (GO:2001053)2.88356838
129energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88136116
130ATP synthesis coupled proton transport (GO:0015986)2.88136116
131SMAD protein signal transduction (GO:0060395)2.84955601
132epithelial cilium movement (GO:0003351)2.78957861
133neuronal stem cell maintenance (GO:0097150)2.76492194
134thalamus development (GO:0021794)2.75552643
135spinal cord motor neuron differentiation (GO:0021522)2.75247355
136reflex (GO:0060004)2.71553294
137primary amino compound metabolic process (GO:1901160)2.69234464
138dopamine transport (GO:0015872)2.68946435
139negative regulation of activin receptor signaling pathway (GO:0032926)2.65020075
140retinal ganglion cell axon guidance (GO:0031290)2.64041930
141serotonin metabolic process (GO:0042428)2.61712014
142translational termination (GO:0006415)2.56033036
143toxin metabolic process (GO:0009404)2.55160140
144viral transcription (GO:0019083)2.54977514
145exogenous drug catabolic process (GO:0042738)2.54478498
146neuronal action potential (GO:0019228)2.54234343
147positive regulation of peptide hormone secretion (GO:0090277)2.54134320
148* regulation of glucokinase activity (GO:0033131)2.51919357
149* regulation of hexokinase activity (GO:1903299)2.51919357
150dendritic spine morphogenesis (GO:0060997)2.49007761
151cotranslational protein targeting to membrane (GO:0006613)2.46112052
152SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.41998704
153nitric oxide mediated signal transduction (GO:0007263)2.41612225
154positive regulation of peptide secretion (GO:0002793)2.41070959
155regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40873344
156glandular epithelial cell development (GO:0002068)2.40212960
157protein targeting to ER (GO:0045047)2.38952269
158negative regulation of axon guidance (GO:1902668)2.37621266
159mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.37314872
160protein complex biogenesis (GO:0070271)2.36412988
161positive regulation of fatty acid beta-oxidation (GO:0032000)2.36334578
162pyrimidine nucleobase catabolic process (GO:0006208)2.35644882
163auditory behavior (GO:0031223)2.35625357
164regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.35031424
165pancreas development (GO:0031016)2.34661033
166regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.34604468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.69346752
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.20762973
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.17325850
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.65387439
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.43766557
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.06286103
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.71441428
8* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61582022
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.50491375
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.45175607
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.09642988
12EZH2_22144423_ChIP-Seq_EOC_Human3.06241683
13* CBX2_27304074_Chip-Seq_ESCs_Mouse2.67780768
14ZNF274_21170338_ChIP-Seq_K562_Hela2.65400034
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54017990
16GBX2_23144817_ChIP-Seq_PC3_Human2.53591338
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51771336
18GATA1_22025678_ChIP-Seq_K562_Human2.40912359
19* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23704703
20VDR_22108803_ChIP-Seq_LS180_Human2.21109990
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18839558
22* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18446156
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17942035
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17329392
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.17143425
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.07404143
27CLOCK_20551151_ChIP-Seq_293T_Human2.03399793
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02541135
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.99331216
30TAF15_26573619_Chip-Seq_HEK293_Human1.95241749
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92783199
32* EZH2_27304074_Chip-Seq_ESCs_Mouse1.92209648
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.87561861
34FUS_26573619_Chip-Seq_HEK293_Human1.86880924
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74869658
36* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74405184
37* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70668697
38P300_19829295_ChIP-Seq_ESCs_Human1.69188376
39* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65535379
40* FOXA2_19822575_ChIP-Seq_HepG2_Human1.64275868
41* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.61624294
42* RNF2_27304074_Chip-Seq_NSC_Mouse1.60516120
43* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60010200
44* REST_21632747_ChIP-Seq_MESCs_Mouse1.57623328
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55140498
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53857877
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52895464
48EWS_26573619_Chip-Seq_HEK293_Human1.51901293
49* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51563198
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.50367938
51* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46926385
52AR_25329375_ChIP-Seq_VCAP_Human1.43508250
53DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43163128
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42832062
55* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39565908
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38926913
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38602895
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.36594796
59* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34781379
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34549882
61* RNF2_27304074_Chip-Seq_ESCs_Mouse1.33662535
62SMAD4_21799915_ChIP-Seq_A2780_Human1.33347629
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32725522
64* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32626170
65* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32626170
66ER_23166858_ChIP-Seq_MCF-7_Human1.31840510
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30592618
68* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30197781
69* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29961792
70* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29961792
71* EZH2_27294783_Chip-Seq_ESCs_Mouse1.28662668
72* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28468591
73GATA4_25053715_ChIP-Seq_YYC3_Human1.27757915
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26992902
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26599897
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22650229
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21721333
78* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21479255
79* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20350895
80* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18813894
81HTT_18923047_ChIP-ChIP_STHdh_Human1.18494294
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17938855
83* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17566505
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.17291473
85* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16040825
86* REST_18959480_ChIP-ChIP_MESCs_Mouse1.15705296
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15008336
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14996566
89AR_21572438_ChIP-Seq_LNCaP_Human1.14105500
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13659310
91* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12884298
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12760513
93IGF1R_20145208_ChIP-Seq_DFB_Human1.12431372
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11937685
95STAT3_23295773_ChIP-Seq_U87_Human1.11778239
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11244228
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10537531
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08352054
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07372213
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04895078
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04795094
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.04781810
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03995356
104* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03935644
105LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03826777
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03403593
107RUNX2_22187159_ChIP-Seq_PCA_Human1.03295057
108* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03293865
109* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02125099
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.01431511
111* TP53_20018659_ChIP-ChIP_R1E_Mouse1.01052778
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00846488
113TRIM28_21343339_ChIP-Seq_HEK293_Human1.00582169
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.00406220
115TCF4_22108803_ChIP-Seq_LS180_Human1.00243973
116SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00241611
117* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99874902
118* RING1B_27294783_Chip-Seq_ESCs_Mouse0.99055587
119* P53_22387025_ChIP-Seq_ESCs_Mouse0.98893379
120SOX2_19829295_ChIP-Seq_ESCs_Human0.98798195
121NANOG_19829295_ChIP-Seq_ESCs_Human0.98798195
122HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98218789
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98026151
124* FOXA1_25552417_ChIP-Seq_VCAP_Human0.95492168
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.93288912
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91763265
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90905816
128STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89355517
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86720871
130RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84964117
131RARB_24833708_ChIP-Seq_LIVER_Mouse0.84712330
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84296318
133* SOX2_20726797_ChIP-Seq_SW620_Human0.83178417
134TP63_17297297_ChIP-ChIP_HaCaT_Human0.83029508
135ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81317528
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81204412
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.81140989
138LXR_22292898_ChIP-Seq_THP-1_Human0.79916683
139GATA6_25053715_ChIP-Seq_YYC3_Human0.79720789
140BCAT_22108803_ChIP-Seq_LS180_Human0.78200652
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77992703
142REST_19997604_ChIP-ChIP_NEURONS_Mouse0.75704652
143* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.74465438
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74201437
145* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73949712
146ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.73588400
147GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71989736
148SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70253262
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.67166969
150GATA3_24758297_ChIP-Seq_MCF-7_Human0.67140217
151AR_20517297_ChIP-Seq_VCAP_Human0.66981964
152PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66759423
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.64890422
154ETV2_25802403_ChIP-Seq_MESCs_Mouse0.63481349
155CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.63450233
156CREB1_26743006_Chip-Seq_LNCaP_Human0.61594124
157EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.59429127
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.59112612
159* SOX17_20123909_ChIP-Seq_XEN_Mouse0.59010376
160TET1_21451524_ChIP-Seq_MESCs_Mouse0.57786432
161GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.57743127
162PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.56152517
163ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.56122059
164CTCF_27219007_Chip-Seq_Bcells_Human0.55696839
165ERG_20517297_ChIP-Seq_VCAP_Human0.54787017
166RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.54542768
167SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54159015
168ZNF263_19887448_ChIP-Seq_K562_Human0.53759898
169PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.52925010
170ZNF217_24962896_ChIP-Seq_MCF-7_Human0.52710603
171BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.51052879
172RUNX1_26923725_Chip-Seq_HPCs_Mouse0.50852712
173FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.50600438
174CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.49803919
175* CDX2_20551321_ChIP-Seq_CACO-2_Human0.49765106
176TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.49655196
177ZFX_18555785_ChIP-Seq_MESCs_Mouse0.49647304
178NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.47294937
179RAD21_21589869_ChIP-Seq_MESCs_Mouse0.46354330
180GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.45985342
181RBPJ_22232070_ChIP-Seq_NCS_Mouse0.45634348
182NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.45431374
183ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.44846330
184CHD1_26751641_Chip-Seq_LNCaP_Human0.44412618
185KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.43519354
186* ISL1_27105846_Chip-Seq_CPCs_Mouse0.43438320
187JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.43224377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.94515932
2MP0005365_abnormal_bile_salt5.51962123
3MP0005360_urolithiasis5.17146262
4MP0005085_abnormal_gallbladder_physiolo5.15755347
5MP0003283_abnormal_digestive_organ3.67699921
6MP0008875_abnormal_xenobiotic_pharmacok3.63618198
7MP0005083_abnormal_biliary_tract3.54144320
8MP0003195_calcinosis3.49087414
9MP0003252_abnormal_bile_duct3.45841306
10MP0000569_abnormal_digit_pigmentation3.23974032
11MP0003806_abnormal_nucleotide_metabolis3.12812987
12MP0005220_abnormal_exocrine_pancreas3.07315939
13MP0001666_abnormal_nutrient_absorption2.94838204
14MP0010329_abnormal_lipoprotein_level2.73639857
15MP0002138_abnormal_hepatobiliary_system2.59056029
16* MP0001944_abnormal_pancreas_morphology2.47204738
17MP0003868_abnormal_feces_composition2.43280511
18* MP0002693_abnormal_pancreas_physiology2.21961544
19MP0009840_abnormal_foam_cell2.21655513
20MP0002909_abnormal_adrenal_gland2.09083276
21MP0005332_abnormal_amino_acid2.06341429
22MP0003136_yellow_coat_color1.98018845
23MP0002837_dystrophic_cardiac_calcinosis1.94580059
24MP0003011_delayed_dark_adaptation1.94437567
25MP0005084_abnormal_gallbladder_morpholo1.85852849
26MP0002877_abnormal_melanocyte_morpholog1.76111731
27* MP0002118_abnormal_lipid_homeostasis1.75521435
28MP0003880_abnormal_central_pattern1.70440629
29MP0004043_abnormal_pH_regulation1.70173419
30MP0005379_endocrine/exocrine_gland_phen1.68612136
31* MP0004133_heterotaxia1.68339358
32* MP0002078_abnormal_glucose_homeostasis1.67174970
33MP0003121_genomic_imprinting1.65457841
34MP0010386_abnormal_urinary_bladder1.64815832
35MP0000013_abnormal_adipose_tissue1.63321461
36MP0000566_synostosis1.63209715
37MP0009780_abnormal_chondrocyte_physiolo1.60640876
38MP0004019_abnormal_vitamin_homeostasis1.60508383
39MP0001905_abnormal_dopamine_level1.60360409
40* MP0000609_abnormal_liver_physiology1.60276768
41MP0009643_abnormal_urine_homeostasis1.59782383
42MP0003123_paternal_imprinting1.57123862
43MP0002928_abnormal_bile_duct1.49315559
44MP0004264_abnormal_extraembryonic_tissu1.47877631
45MP0002102_abnormal_ear_morphology1.47237880
46MP0000462_abnormal_digestive_system1.42052109
47MP0008995_early_reproductive_senescence1.39712281
48MP0004742_abnormal_vestibular_system1.36581019
49MP0000778_abnormal_nervous_system1.34046939
50MP0003315_abnormal_perineum_morphology1.32090375
51MP0005408_hypopigmentation1.29218516
52MP0002822_catalepsy1.28289746
53MP0002557_abnormal_social/conspecific_i1.27993842
54MP0002234_abnormal_pharynx_morphology1.25557882
55MP0003183_abnormal_peptide_metabolism1.24471325
56MP0001764_abnormal_homeostasis1.24267824
57MP0005636_abnormal_mineral_homeostasis1.22283983
58MP0006292_abnormal_olfactory_placode1.21855786
59MP0005551_abnormal_eye_electrophysiolog1.20872336
60MP0009046_muscle_twitch1.20607035
61MP0000678_abnormal_parathyroid_gland1.20515869
62MP0003191_abnormal_cellular_cholesterol1.19141354
63MP0001485_abnormal_pinna_reflex1.17120202
64MP0001986_abnormal_taste_sensitivity1.16443212
65MP0004782_abnormal_surfactant_physiolog1.16093294
66MP0005319_abnormal_enzyme/_coenzyme1.12845733
67MP0004142_abnormal_muscle_tone1.12756729
68MP0009745_abnormal_behavioral_response1.08809849
69MP0003937_abnormal_limbs/digits/tail_de1.08193289
70MP0004924_abnormal_behavior1.07564909
71MP0005386_behavior/neurological_phenoty1.07564909
72MP0002184_abnormal_innervation1.04919685
73MP0003938_abnormal_ear_development1.04376745
74MP0001756_abnormal_urination1.02915206
75MP0002572_abnormal_emotion/affect_behav1.02765888
76MP0000538_abnormal_urinary_bladder1.00393218
77* MP0003953_abnormal_hormone_level1.00313796
78* MP0002064_seizures1.00248193
79MP0001440_abnormal_grooming_behavior0.94545303
80MP0004885_abnormal_endolymph0.94258251
81MP0004270_analgesia0.93279402
82MP0000026_abnormal_inner_ear0.93273236
83MP0002282_abnormal_trachea_morphology0.92632239
84MP0002272_abnormal_nervous_system0.92103582
85MP0002734_abnormal_mechanical_nocicepti0.89853792
86MP0009053_abnormal_anal_canal0.89084520
87* MP0003119_abnormal_digestive_system0.88444570
88MP0005448_abnormal_energy_balance0.88185700
89MP0002653_abnormal_ependyma_morphology0.87389459
90* MP0009642_abnormal_blood_homeostasis0.86141878
91MP0001486_abnormal_startle_reflex0.85907307
92MP0000383_abnormal_hair_follicle0.84435258
93MP0005253_abnormal_eye_physiology0.84076558
94MP0000598_abnormal_liver_morphology0.83431237
95MP0003787_abnormal_imprinting0.83015212
96MP0003943_abnormal_hepatobiliary_system0.80819053
97MP0002896_abnormal_bone_mineralization0.80607185
98MP0000613_abnormal_salivary_gland0.80273001
99MP0005535_abnormal_body_temperature0.80186000
100* MP0003959_abnormal_lean_body0.79050705
101MP0005584_abnormal_enzyme/coenzyme_acti0.78634940
102MP0000003_abnormal_adipose_tissue0.78596683
103MP0005195_abnormal_posterior_eye0.78411659
104MP0002876_abnormal_thyroid_physiology0.77259594
105MP0002163_abnormal_gland_morphology0.76999979
106MP0008877_abnormal_DNA_methylation0.76676406
107MP0008872_abnormal_physiological_respon0.75823165
108MP0001293_anophthalmia0.73192150
109* MP0003890_abnormal_embryonic-extraembry0.72949672
110MP0001346_abnormal_lacrimal_gland0.72786790
111MP0009672_abnormal_birth_weight0.72584909
112MP0006072_abnormal_retinal_apoptosis0.72372266
113MP0002089_abnormal_postnatal_growth/wei0.71012132
114* MP0002067_abnormal_sensory_capabilities0.69991394
115MP0002638_abnormal_pupillary_reflex0.69720955
116MP0005334_abnormal_fat_pad0.69580343
117MP0001765_abnormal_ion_homeostasis0.69557403
118MP0001324_abnormal_eye_pigmentation0.69056224
119MP0005058_abnormal_lysosome_morphology0.68367801
120MP0000639_abnormal_adrenal_gland0.67461832
121MP0010368_abnormal_lymphatic_system0.66928064
122MP0002098_abnormal_vibrissa_morphology0.66214712
123MP0003186_abnormal_redox_activity0.63684464
124MP0003122_maternal_imprinting0.61934224
125MP0005187_abnormal_penis_morphology0.61334729
126MP0002938_white_spotting0.60814171
127MP0009697_abnormal_copulation0.57806525
128MP0003300_gastrointestinal_ulcer0.55925619
129MP0006276_abnormal_autonomic_nervous0.55021958
130MP0006036_abnormal_mitochondrial_physio0.53745613
131MP0009379_abnormal_foot_pigmentation0.53065998
132MP0005646_abnormal_pituitary_gland0.52618258
133MP0005257_abnormal_intraocular_pressure0.50484426
134MP0001529_abnormal_vocalization0.50158692
135MP0010234_abnormal_vibrissa_follicle0.48958058
136MP0000230_abnormal_systemic_arterial0.48417377
137MP0000467_abnormal_esophagus_morphology0.47575217
138MP0001664_abnormal_digestion0.47571419
139MP0002168_other_aberrant_phenotype0.45350774
140MP0003172_abnormal_lysosome_physiology0.44171959
141MP0009384_cardiac_valve_regurgitation0.43580763
142MP0003329_amyloid_beta_deposits0.42709509
143MP0000579_abnormal_nail_morphology0.42431149
144MP0005248_abnormal_Harderian_gland0.41619696
145MP0000537_abnormal_urethra_morphology0.41099261
146* MP0005376_homeostasis/metabolism_phenot0.39897932
147MP0009763_increased_sensitivity_to0.39666599
148MP0002751_abnormal_autonomic_nervous0.39304921
149MP0000604_amyloidosis0.38420617
150MP0002971_abnormal_brown_adipose0.37660676
151MP0005645_abnormal_hypothalamus_physiol0.36834313
152MP0000631_abnormal_neuroendocrine_gland0.36584290

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.33991980
2Hypoglycemic coma (HP:0001325)6.61873936
3Hypoglycemic seizures (HP:0002173)6.31923316
4Hyperinsulinemic hypoglycemia (HP:0000825)6.23507338
5Intrahepatic cholestasis (HP:0001406)5.68073220
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.24819592
7Symptomatic seizures (HP:0011145)5.18083107
8Deep venous thrombosis (HP:0002625)5.14571626
9Prolonged partial thromboplastin time (HP:0003645)5.02946081
10Ketoacidosis (HP:0001993)4.84874456
11Hypobetalipoproteinemia (HP:0003563)4.58687706
12Ketosis (HP:0001946)4.54619588
13Xanthomatosis (HP:0000991)4.44759020
14Late onset (HP:0003584)4.39845825
15Abnormality of the intrinsic pathway (HP:0010989)4.27102126
16Abnormality of endocrine pancreas physiology (HP:0012093)4.24181492
17Abnormality of the pancreatic islet cells (HP:0006476)4.24181492
18Conjugated hyperbilirubinemia (HP:0002908)4.14176137
19Abnormality of the common coagulation pathway (HP:0010990)4.08298755
20Hypothermia (HP:0002045)4.07707197
21Hyperglycemia (HP:0003074)4.04257200
22Hyperlipoproteinemia (HP:0010980)3.69846391
23Pancreatic islet-cell hyperplasia (HP:0004510)3.53193120
24Fat malabsorption (HP:0002630)3.50517710
25Complement deficiency (HP:0004431)3.49125066
26Limb dystonia (HP:0002451)3.45051089
27Gout (HP:0001997)3.28449577
28Congenital, generalized hypertrichosis (HP:0004540)3.25237125
29Hyperglycinemia (HP:0002154)3.22093159
30Joint hemorrhage (HP:0005261)3.19074347
31Hypolipoproteinemia (HP:0010981)3.14889137
32Hyperammonemia (HP:0001987)3.07041665
33Epidermoid cyst (HP:0200040)3.06944623
34Bilateral microphthalmos (HP:0007633)3.04241103
35True hermaphroditism (HP:0010459)3.04131158
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04084416
37Generalized aminoaciduria (HP:0002909)3.02125060
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.01603855
39Abnormal pancreas size (HP:0012094)2.99581703
40Skin nodule (HP:0200036)2.84607244
41Sex reversal (HP:0012245)2.84083114
42Abnormal sex determination (HP:0012244)2.84083114
43Pancreatic cysts (HP:0001737)2.81768079
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.81652451
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.80959103
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.80899159
47Insulin-resistant diabetes mellitus (HP:0000831)2.78402345
48Abnormality of purine metabolism (HP:0004352)2.71032829
49Retinal atrophy (HP:0001105)2.70472133
50Hyperbilirubinemia (HP:0002904)2.69775849
51Intestinal atresia (HP:0011100)2.69311934
52Prominent supraorbital ridges (HP:0000336)2.63087095
53Insulin resistance (HP:0000855)2.63041795
54Pancreatic fibrosis (HP:0100732)2.59619690
55Maternal diabetes (HP:0009800)2.54843659
56Abnormality of methionine metabolism (HP:0010901)2.54101771
57Hyperglycinuria (HP:0003108)2.53367652
58Anophthalmia (HP:0000528)2.53108210
59Abnormality of glycine metabolism (HP:0010895)2.52991866
60Abnormality of serine family amino acid metabolism (HP:0010894)2.52991866
61Abnormality of nucleobase metabolism (HP:0010932)2.52444256
62Abnormality of midbrain morphology (HP:0002418)2.50583975
63Molar tooth sign on MRI (HP:0002419)2.50583975
64Hypoalphalipoproteinemia (HP:0003233)2.50491010
65Type II lissencephaly (HP:0007260)2.50123175
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48352582
67Irritability (HP:0000737)2.48329668
68Abnormality of fatty-acid metabolism (HP:0004359)2.47666899
69Abnormality of complement system (HP:0005339)2.42020640
70Vascular calcification (HP:0004934)2.37323096
71Glycosuria (HP:0003076)2.36768805
72Abnormality of urine glucose concentration (HP:0011016)2.36768805
73Nephronophthisis (HP:0000090)2.33807430
74Enlarged kidneys (HP:0000105)2.33193807
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31365660
76Large for gestational age (HP:0001520)2.31091500
77Steatorrhea (HP:0002570)2.30609568
78Cystic liver disease (HP:0006706)2.28853769
79Urinary glycosaminoglycan excretion (HP:0003541)2.25919962
80Mucopolysacchariduria (HP:0008155)2.25919962
81Metabolic acidosis (HP:0001942)2.24990193
82Abnormal ciliary motility (HP:0012262)2.24230467
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23672721
84Dicarboxylic aciduria (HP:0003215)2.23672721
85Hypercholesterolemia (HP:0003124)2.18518766
86Abnormality of calcium-phosphate metabolism (HP:0100530)2.18327760
87Abnormal respiratory epithelium morphology (HP:0012253)2.15753492
88Abnormal respiratory motile cilium morphology (HP:0005938)2.15753492
89Increased hepatocellular lipid droplets (HP:0006565)2.15710550
90Abnormality of pyrimidine metabolism (HP:0004353)2.15267109
91Concave nail (HP:0001598)2.13848856
92Male pseudohermaphroditism (HP:0000037)2.13478379
93Chronic hepatic failure (HP:0100626)2.13303855
94Abnormality of polysaccharide metabolism (HP:0011012)2.13070382
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13070382
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13070382
97Abnormality of the renal cortex (HP:0011035)2.12954378
98Abdominal distention (HP:0003270)2.12901718
99Congenital stationary night blindness (HP:0007642)2.11342854
100Epileptiform EEG discharges (HP:0011182)2.10930543
101EEG with generalized epileptiform discharges (HP:0011198)2.10615622
102Esophageal varix (HP:0002040)2.10074780
103Oligodactyly (hands) (HP:0001180)2.10031942
104Brushfield spots (HP:0001088)2.08791126
105Delayed CNS myelination (HP:0002188)2.08356799
106Acute necrotizing encephalopathy (HP:0006965)2.08096590
107Aplasia/hypoplasia of the uterus (HP:0008684)2.06834449
108Hepatocellular carcinoma (HP:0001402)2.05648739
109Abnormal number of erythroid precursors (HP:0012131)2.04064237
110Proximal tubulopathy (HP:0000114)2.02974692
111Hyperphosphaturia (HP:0003109)2.02114599
112Abnormal enzyme/coenzyme activity (HP:0012379)2.01589967
113Limb hypertonia (HP:0002509)2.01388299
114Glomerulonephritis (HP:0000099)2.01291324
115Hepatic necrosis (HP:0002605)2.00132415
116Gastrointestinal atresia (HP:0002589)1.99917208
117Lethargy (HP:0001254)1.99823553
118Abnormality of the renal medulla (HP:0100957)1.99440871
119Mitochondrial inheritance (HP:0001427)1.99319323
120Agitation (HP:0000713)1.98440075
121Renal cortical cysts (HP:0000803)1.97496617
122Abnormality of serum amino acid levels (HP:0003112)1.95005203
123Abnormality of the vitreous humor (HP:0004327)1.94841338
124Osteomalacia (HP:0002749)1.94370661
125Abnormality of vitamin metabolism (HP:0100508)1.94201907
126Malnutrition (HP:0004395)1.93201058
127Progressive macrocephaly (HP:0004481)1.93192393
128Pendular nystagmus (HP:0012043)1.92722870
129Elevated alkaline phosphatase (HP:0003155)1.90962435
130Septo-optic dysplasia (HP:0100842)1.90929737
131Pancreatitis (HP:0001733)1.90839643
132Tachypnea (HP:0002789)1.90765696
133Protuberant abdomen (HP:0001538)1.90127479
134Midline defect of the nose (HP:0004122)1.89880472
135Abnormality of alkaline phosphatase activity (HP:0004379)1.89857190
136Abnormal gallbladder morphology (HP:0012437)1.88935926
137Furrowed tongue (HP:0000221)1.88685735
138Macrocytic anemia (HP:0001972)1.88276441
139Hypophosphatemia (HP:0002148)1.88238412
140Arthropathy (HP:0003040)1.88142913
141Cardiovascular calcification (HP:0011915)1.88075590
142Decreased circulating renin level (HP:0003351)1.87374626
143Acute encephalopathy (HP:0006846)1.86386003
144Cerebellar dysplasia (HP:0007033)1.86123424
145Scrotal hypoplasia (HP:0000046)1.86117107
1463-Methylglutaconic aciduria (HP:0003535)1.85594833
147Esophageal atresia (HP:0002032)1.83912366
148Medial flaring of the eyebrow (HP:0010747)1.83433422
149Renal Fanconi syndrome (HP:0001994)1.83148050
150Spontaneous abortion (HP:0005268)1.82493217
151Methylmalonic acidemia (HP:0002912)1.82384374
152Abnormality of vitamin B metabolism (HP:0004340)1.82280475
153Focal motor seizures (HP:0011153)1.81448339
154Death in childhood (HP:0003819)1.80035901
155Hemiparesis (HP:0001269)1.78992135
156Abnormal cartilage morphology (HP:0002763)1.78889783
157Exocrine pancreatic insufficiency (HP:0001738)1.78388155
158Dysostosis multiplex (HP:0000943)1.76933634
159Lipid accumulation in hepatocytes (HP:0006561)1.76920167
160Abnormal respiratory motile cilium physiology (HP:0012261)1.76504140
161Double outlet right ventricle (HP:0001719)1.76343302
162Congenital malformation of the right heart (HP:0011723)1.76343302
163Sclerocornea (HP:0000647)1.76254178
164Alkalosis (HP:0001948)1.75985309
165Occipital encephalocele (HP:0002085)1.74875848
166Mitral stenosis (HP:0001718)1.74404688
167Acute hepatic failure (HP:0006554)1.73661394
168Fair hair (HP:0002286)1.72353075
169Anterior segment dysgenesis (HP:0007700)1.71607042
170Potter facies (HP:0002009)1.71386744
171Facial shape deformation (HP:0011334)1.71386744
172Hepatoblastoma (HP:0002884)1.70155330
173Hypsarrhythmia (HP:0002521)1.68995139
174Labial hypoplasia (HP:0000066)1.68529438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.48206937
2PNCK6.31656567
3MAPK154.82441816
4PASK4.27473884
5ERN13.99237841
6BCKDK3.59160082
7TAOK33.26632289
8FGFR43.23057018
9SIK12.83200341
10CASK2.74996884
11WNK32.60317134
12NTRK32.54092370
13FRK2.38012781
14WEE12.29362981
15TNIK2.04740002
16MARK12.01159365
17ADRBK22.00734545
18HIPK21.97684876
19DYRK1B1.78620820
20MAP3K21.75212420
21FLT31.75167477
22EPHA21.69818700
23PDGFRA1.62435287
24MAP3K41.60587791
25WNK41.58258987
26UHMK11.57753178
27SIK31.57386678
28PRKD31.56596370
29TRIB31.52998910
30FGFR21.51978474
31PTK61.50958803
32BCR1.48271690
33VRK21.48102562
34PIK3CG1.48063166
35ERBB41.47875762
36PINK11.45722677
37PHKG21.40177845
38PHKG11.40177845
39PTK21.38356990
40VRK11.37599087
41PRKCG1.36828671
42MAPK131.33962906
43MAP2K21.33290088
44DYRK31.31820272
45EPHB21.22299668
46TAF11.14534502
47MKNK21.13915336
48PAK31.12831473
49NME11.11627133
50KSR11.08232313
51CDK31.08066532
52TSSK61.05911658
53MST1R1.03790162
54CDC42BPA1.02912723
55ERBB21.01030690
56MET0.96658354
57MAP3K10.95417624
58NTRK20.88699194
59IRAK10.86080239
60DYRK20.84907023
61EPHA30.84709416
62STK160.84293206
63BRD40.84171248
64ACVR1B0.83201453
65TLK10.81078273
66LMTK20.80105996
67MAP4K20.78531350
68IRAK20.77685913
69STK390.76108449
70MKNK10.75207346
71ADRBK10.74914483
72SGK20.74850802
73SGK2230.72333554
74SGK4940.72333554
75MAP2K70.70413855
76MAPK110.70318160
77MAP3K100.70018352
78FER0.67995357
79BRSK10.67326207
80LATS10.66645412
81ZAK0.64940415
82IRAK30.64626165
83NEK20.64258208
84STK38L0.63217852
85TAOK10.62700406
86PKN20.61560408
87STK110.61542202
88MELK0.60369247
89NTRK10.60094124
90PLK30.59376368
91AKT30.58291590
92PRKCZ0.57565751
93MAP2K40.57383974
94GSK3A0.57091848
95MAPKAPK50.57065837
96STK30.56137445
97PTK2B0.56117032
98RET0.54640914
99MTOR0.52787870
100CSNK1E0.51350347
101MAP3K30.51033992
102ABL20.50012553
103NLK0.49348585
104MAP2K10.48899898
105PRKG10.48440630
106DAPK20.47107623
107PRKACG0.46815641
108BUB10.45451180
109ERBB30.45123199
110DYRK1A0.45044852
111CAMK2D0.44898477
112JAK20.44835667
113CDK80.44557097
114OXSR10.43704516
115PRKAA10.42293074
116BRAF0.41955737
117SGK10.40819004
118EIF2AK30.40234074
119PRKACB0.38962323
120CAMK2A0.37740614
121YES10.37498267
122TRIM280.37220160
123EPHA40.36619041
124CSNK1G30.35954795
125BRSK20.35653292
126CSNK1G10.35310116
127SCYL20.35296817
128ITK0.34325401
129FGFR30.34177282
130PRKCI0.33198662
131PRKCE0.30618273
132CAMK1D0.29823934
133PRKAA20.28442492
134CSNK1A1L0.26786431
135MAP2K60.26454930
136CSNK1G20.26433179
137IGF1R0.26352977
138PRKD20.26031815
139ICK0.25055645
140TYRO30.25041963
141CAMK2G0.24325613
142FGFR10.23875006
143CAMKK20.23695495
144PDGFRB0.22479970
145BMPR1B0.21984674
146PRKG20.21831207
147NEK90.21241964
148CSNK1A10.20402130
149PRKD10.20289007
150CAMK2B0.18706843
151PRKACA0.18461120
152CAMK1G0.18459545
153CSK0.18457432
154AURKA0.16889619
155GRK10.16766735
156TIE10.16637602
157TGFBR10.15897281

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049505.89084471
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.71084578
3Nitrogen metabolism_Homo sapiens_hsa009102.89478214
4Tryptophan metabolism_Homo sapiens_hsa003802.88918745
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83516207
6Sulfur metabolism_Homo sapiens_hsa009202.78075403
7Oxidative phosphorylation_Homo sapiens_hsa001902.51837553
8Protein export_Homo sapiens_hsa030602.45290868
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37692724
10Selenocompound metabolism_Homo sapiens_hsa004502.32558325
11Fatty acid degradation_Homo sapiens_hsa000712.23992893
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.22129236
13Butanoate metabolism_Homo sapiens_hsa006502.20220004
14Arginine biosynthesis_Homo sapiens_hsa002202.17010152
15Complement and coagulation cascades_Homo sapiens_hsa046102.16882195
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05564042
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02986341
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02935124
19Folate biosynthesis_Homo sapiens_hsa007901.93315951
20Histidine metabolism_Homo sapiens_hsa003401.89637331
21Ribosome_Homo sapiens_hsa030101.87677942
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86154236
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78397687
24Peroxisome_Homo sapiens_hsa041461.77704699
25Parkinsons disease_Homo sapiens_hsa050121.77020217
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.68515631
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64188351
28Phenylalanine metabolism_Homo sapiens_hsa003601.63366097
29Fat digestion and absorption_Homo sapiens_hsa049751.57512798
30Fatty acid metabolism_Homo sapiens_hsa012121.47859072
31Tyrosine metabolism_Homo sapiens_hsa003501.45919813
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44372173
33Chemical carcinogenesis_Homo sapiens_hsa052041.42170894
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37874451
35Propanoate metabolism_Homo sapiens_hsa006401.36511298
36Starch and sucrose metabolism_Homo sapiens_hsa005001.35629629
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.35330308
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31329002
39PPAR signaling pathway_Homo sapiens_hsa033201.31114292
40Cardiac muscle contraction_Homo sapiens_hsa042601.30492751
41Retinol metabolism_Homo sapiens_hsa008301.28468836
42Alzheimers disease_Homo sapiens_hsa050101.27935883
43beta-Alanine metabolism_Homo sapiens_hsa004101.27834950
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27629842
45ABC transporters_Homo sapiens_hsa020101.26998977
46Nicotine addiction_Homo sapiens_hsa050331.26708550
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23392152
48Fatty acid elongation_Homo sapiens_hsa000621.20784360
49Bile secretion_Homo sapiens_hsa049761.19612681
50Huntingtons disease_Homo sapiens_hsa050161.15311820
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13692104
52Lysine degradation_Homo sapiens_hsa003101.07850551
53Pyruvate metabolism_Homo sapiens_hsa006201.06214061
54Insulin secretion_Homo sapiens_hsa049111.06157223
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05184290
56Basal cell carcinoma_Homo sapiens_hsa052171.03130227
57Taste transduction_Homo sapiens_hsa047421.02703635
58Ether lipid metabolism_Homo sapiens_hsa005651.01923027
59Steroid biosynthesis_Homo sapiens_hsa001000.99109315
60Caffeine metabolism_Homo sapiens_hsa002320.96737739
61Amphetamine addiction_Homo sapiens_hsa050310.95186500
62Staphylococcus aureus infection_Homo sapiens_hsa051500.91918230
63Arginine and proline metabolism_Homo sapiens_hsa003300.90758260
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88861727
65Phototransduction_Homo sapiens_hsa047440.84943903
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82738515
67Prion diseases_Homo sapiens_hsa050200.81504225
68Collecting duct acid secretion_Homo sapiens_hsa049660.81430316
69Mineral absorption_Homo sapiens_hsa049780.81002104
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75402962
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.74151290
72Carbon metabolism_Homo sapiens_hsa012000.73218935
73Serotonergic synapse_Homo sapiens_hsa047260.71563073
74Sulfur relay system_Homo sapiens_hsa041220.70255879
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69363704
76Biosynthesis of amino acids_Homo sapiens_hsa012300.67901100
77Arachidonic acid metabolism_Homo sapiens_hsa005900.67303164
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67258901
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66120366
80Hedgehog signaling pathway_Homo sapiens_hsa043400.66054297
81TGF-beta signaling pathway_Homo sapiens_hsa043500.64832806
82Glutamatergic synapse_Homo sapiens_hsa047240.64091665
83Type II diabetes mellitus_Homo sapiens_hsa049300.63307581
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60826171
85Vitamin digestion and absorption_Homo sapiens_hsa049770.60622549
86Dopaminergic synapse_Homo sapiens_hsa047280.60479392
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.60205341
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59906609
89Ovarian steroidogenesis_Homo sapiens_hsa049130.57977943
90N-Glycan biosynthesis_Homo sapiens_hsa005100.57649345
91Galactose metabolism_Homo sapiens_hsa000520.56115651
92GABAergic synapse_Homo sapiens_hsa047270.55319910
93Vibrio cholerae infection_Homo sapiens_hsa051100.55185164
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53865645
95Glucagon signaling pathway_Homo sapiens_hsa049220.51843945
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50471782
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50212010
98One carbon pool by folate_Homo sapiens_hsa006700.48873560
99Fatty acid biosynthesis_Homo sapiens_hsa000610.48838302
100RNA polymerase_Homo sapiens_hsa030200.48698227
101Insulin resistance_Homo sapiens_hsa049310.48426190
102Circadian entrainment_Homo sapiens_hsa047130.47256199
103Metabolic pathways_Homo sapiens_hsa011000.47223744
104Linoleic acid metabolism_Homo sapiens_hsa005910.46589885
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44963836
106Cocaine addiction_Homo sapiens_hsa050300.44478956
107Axon guidance_Homo sapiens_hsa043600.44133854
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42205427
109Glutathione metabolism_Homo sapiens_hsa004800.40102870
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38859780
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38212565
112Glycerolipid metabolism_Homo sapiens_hsa005610.37656540
113Pancreatic secretion_Homo sapiens_hsa049720.35709989
114Basal transcription factors_Homo sapiens_hsa030220.35123954
115Lysosome_Homo sapiens_hsa041420.34478907
116Regulation of autophagy_Homo sapiens_hsa041400.32645590
117Wnt signaling pathway_Homo sapiens_hsa043100.31612373
118Dorso-ventral axis formation_Homo sapiens_hsa043200.30918714
119Type I diabetes mellitus_Homo sapiens_hsa049400.30077767
120Pentose phosphate pathway_Homo sapiens_hsa000300.29567409
121Thyroid hormone synthesis_Homo sapiens_hsa049180.23745998
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.22687017
123Vitamin B6 metabolism_Homo sapiens_hsa007500.21638024
124Fructose and mannose metabolism_Homo sapiens_hsa000510.18972336
125Bladder cancer_Homo sapiens_hsa052190.17237684
126Circadian rhythm_Homo sapiens_hsa047100.16815784
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16340865
128Other glycan degradation_Homo sapiens_hsa005110.15051682
129Protein digestion and absorption_Homo sapiens_hsa049740.14638670
130AMPK signaling pathway_Homo sapiens_hsa041520.13027158
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.11663481
132Insulin signaling pathway_Homo sapiens_hsa049100.07244630
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06419910
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06262047
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06156131

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