FOXA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53388040
2L-phenylalanine catabolic process (GO:0006559)7.53388040
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25068966
4L-phenylalanine metabolic process (GO:0006558)7.25068966
5aromatic amino acid family catabolic process (GO:0009074)6.62851268
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.09045556
7indole-containing compound catabolic process (GO:0042436)5.88763613
8indolalkylamine catabolic process (GO:0046218)5.88763613
9tryptophan catabolic process (GO:0006569)5.88763613
10bile acid biosynthetic process (GO:0006699)5.69887679
11kynurenine metabolic process (GO:0070189)5.67650987
12urea cycle (GO:0000050)5.60279036
13urea metabolic process (GO:0019627)5.60279036
14tryptophan metabolic process (GO:0006568)5.58165538
15glyoxylate metabolic process (GO:0046487)5.57849723
16negative regulation of fibrinolysis (GO:0051918)5.50145163
17high-density lipoprotein particle remodeling (GO:0034375)5.43612643
18regulation of fibrinolysis (GO:0051917)5.37776468
19sulfur amino acid catabolic process (GO:0000098)5.30680067
20epoxygenase P450 pathway (GO:0019373)5.29884530
21regulation of protein activation cascade (GO:2000257)5.28192146
22cysteine metabolic process (GO:0006534)5.25225801
23protein carboxylation (GO:0018214)5.24233543
24peptidyl-glutamic acid carboxylation (GO:0017187)5.24233543
25complement activation, alternative pathway (GO:0006957)5.23147138
26nitrogen cycle metabolic process (GO:0071941)5.15550601
27alpha-linolenic acid metabolic process (GO:0036109)5.05398926
28bile acid metabolic process (GO:0008206)4.97768535
29regulation of complement activation (GO:0030449)4.90775337
30serine family amino acid catabolic process (GO:0009071)4.87278413
31reverse cholesterol transport (GO:0043691)4.85804816
32aromatic amino acid family metabolic process (GO:0009072)4.85311800
33homocysteine metabolic process (GO:0050667)4.84345721
34L-serine metabolic process (GO:0006563)4.81924660
35regulation of triglyceride catabolic process (GO:0010896)4.81434795
36regulation of cholesterol esterification (GO:0010872)4.78630803
37protein-lipid complex remodeling (GO:0034368)4.77625143
38macromolecular complex remodeling (GO:0034367)4.77625143
39plasma lipoprotein particle remodeling (GO:0034369)4.77625143
40acylglycerol homeostasis (GO:0055090)4.72131524
41triglyceride homeostasis (GO:0070328)4.72131524
42tyrosine metabolic process (GO:0006570)4.63392680
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.59964155
44ethanol metabolic process (GO:0006067)4.55987966
45phospholipid efflux (GO:0033700)4.54104114
46exogenous drug catabolic process (GO:0042738)4.49968436
47alpha-amino acid catabolic process (GO:1901606)4.45404136
48coenzyme catabolic process (GO:0009109)4.42815210
49bile acid and bile salt transport (GO:0015721)4.40036414
50amino-acid betaine metabolic process (GO:0006577)4.31601883
51lysine catabolic process (GO:0006554)4.31521800
52lysine metabolic process (GO:0006553)4.31521800
53negative regulation of sterol transport (GO:0032372)4.28001337
54negative regulation of cholesterol transport (GO:0032375)4.28001337
55glycine metabolic process (GO:0006544)4.26679362
56indolalkylamine metabolic process (GO:0006586)4.24876441
57intestinal absorption (GO:0050892)4.24043668
58plasma lipoprotein particle clearance (GO:0034381)4.18492204
59cellular ketone body metabolic process (GO:0046950)4.15989568
60cellular amino acid catabolic process (GO:0009063)4.14981523
61cholesterol efflux (GO:0033344)4.13424074
62cellular biogenic amine catabolic process (GO:0042402)4.11105293
63amine catabolic process (GO:0009310)4.11105293
64cellular glucuronidation (GO:0052695)4.10604800
65cellular modified amino acid catabolic process (GO:0042219)4.09776804
66regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.09120947
67serine family amino acid metabolic process (GO:0009069)4.05530845
68imidazole-containing compound metabolic process (GO:0052803)4.05248044
69proline metabolic process (GO:0006560)4.04702474
70intestinal cholesterol absorption (GO:0030299)4.01908171
71plasma lipoprotein particle assembly (GO:0034377)3.99111522
72glutamate metabolic process (GO:0006536)3.97815329
73low-density lipoprotein particle remodeling (GO:0034374)3.92834657
74blood coagulation, intrinsic pathway (GO:0007597)3.90096532
75fibrinolysis (GO:0042730)3.89920749
76serine family amino acid biosynthetic process (GO:0009070)3.88921437
77benzene-containing compound metabolic process (GO:0042537)3.87925713
78positive regulation of lipoprotein lipase activity (GO:0051006)3.86380378
79positive regulation of triglyceride lipase activity (GO:0061365)3.86380378
80arginine metabolic process (GO:0006525)3.83689160
81cofactor catabolic process (GO:0051187)3.82149979
82primary alcohol catabolic process (GO:0034310)3.82147956
83regulation of bile acid biosynthetic process (GO:0070857)3.81647397
84aldehyde catabolic process (GO:0046185)3.79368032
85omega-hydroxylase P450 pathway (GO:0097267)3.78248264
86cytolysis (GO:0019835)3.77585837
87protein-lipid complex subunit organization (GO:0071825)3.74424998
88regulation of cholesterol homeostasis (GO:2000188)3.72758657
89cholesterol homeostasis (GO:0042632)3.72232314
90drug metabolic process (GO:0017144)3.68425466
91complement activation, classical pathway (GO:0006958)3.68407982
92very-low-density lipoprotein particle assembly (GO:0034379)3.67300980
93protein activation cascade (GO:0072376)3.67047381
94sterol homeostasis (GO:0055092)3.65980164
95ethanol oxidation (GO:0006069)3.65485164
96plasma lipoprotein particle organization (GO:0071827)3.65151294
97regulation of apoptotic cell clearance (GO:2000425)3.64250095
98phospholipid homeostasis (GO:0055091)3.64075325
99negative regulation of lipase activity (GO:0060192)3.64046526
100glucuronate metabolic process (GO:0019585)3.63804619
101uronic acid metabolic process (GO:0006063)3.63804619
102organic acid catabolic process (GO:0016054)3.63089627
103carboxylic acid catabolic process (GO:0046395)3.63089627
104acute-phase response (GO:0006953)3.61153264
105complement activation (GO:0006956)3.59110585
106ketone body metabolic process (GO:1902224)3.58629716
107drug catabolic process (GO:0042737)3.57025826
108dicarboxylic acid biosynthetic process (GO:0043650)3.55690533
109regulation of plasminogen activation (GO:0010755)3.55246613
110lipoprotein metabolic process (GO:0042157)3.54518572
111positive regulation of lipid catabolic process (GO:0050996)3.53299618
112protein-lipid complex assembly (GO:0065005)3.52841376
113negative regulation of hemostasis (GO:1900047)3.50575889
114negative regulation of blood coagulation (GO:0030195)3.50575889
115positive regulation of fatty acid biosynthetic process (GO:0045723)3.48689955
116folic acid-containing compound biosynthetic process (GO:0009396)3.46912668
117glutamine family amino acid biosynthetic process (GO:0009084)3.44737342
118heme transport (GO:0015886)3.44415220
119aminoglycoside antibiotic metabolic process (GO:0030647)3.40764470
120tetrahydrofolate metabolic process (GO:0046653)3.34798404
121negative regulation of coagulation (GO:0050819)3.29235461
122desmosome organization (GO:0002934)3.24874587
123primary alcohol metabolic process (GO:0034308)3.18935053
124renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.17944511
125negative regulation of wound healing (GO:0061045)3.12862447
126lipoprotein transport (GO:0042953)3.11949858
127L-ascorbic acid metabolic process (GO:0019852)3.08305313
128diacylglycerol metabolic process (GO:0046339)3.06945521
129regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.04237824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.17783679
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.09898719
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.90352316
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.31847076
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28865125
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.27247529
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.50528620
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06188667
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83227048
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59671123
11E2F7_22180533_ChIP-Seq_HELA_Human2.45976635
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.31978640
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29527153
14AR_21909140_ChIP-Seq_LNCAP_Human2.16533289
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.06295514
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01148683
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7750845
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98225221
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.95995986
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95415406
21GATA1_22025678_ChIP-Seq_K562_Human1.84491164
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59580006
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58685067
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58685067
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58685067
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.58490221
27TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50567568
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49610078
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47567016
30CLOCK_20551151_ChIP-Seq_293T_Human1.45170986
31HTT_18923047_ChIP-ChIP_STHdh_Human1.43582256
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41244765
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39061808
34SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36174904
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36078853
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34262482
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33912435
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.33748237
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29476501
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23473857
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21887287
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20257964
43RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19787620
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17724744
45SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13296817
46NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12925771
47GATA4_25053715_ChIP-Seq_YYC3_Human1.12737248
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11482599
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.11273935
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10430229
51OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08200927
52* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03568838
53* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02376038
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.01123971
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01019050
56RACK7_27058665_Chip-Seq_MCF-7_Human0.98626950
57ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94550295
58SOX2_22085726_ChIP-Seq_NPCs_Mouse0.91955996
59XRN2_22483619_ChIP-Seq_HELA_Human0.91096231
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89278799
61TET1_21451524_ChIP-Seq_MESCs_Mouse0.89152711
62YY1_22570637_ChIP-Seq_MALME-3M_Human0.89008105
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87434236
64* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87002813
65SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86943245
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85063809
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85018824
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84960528
69NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84792255
70NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84334176
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82806195
72RARA_24833708_ChIP-Seq_LIVER_Mouse0.82560614
73TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81765919
74KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81618064
75ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81598189
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.79766208
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79736723
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79156472
79P68_20966046_ChIP-Seq_HELA_Human0.77752078
80* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76150342
81GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76008228
82POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75847266
83BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75838680
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.75686787
85POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.75372245
86ETS1_21867929_ChIP-Seq_TH2_Mouse0.74965936
87TCF4_18268006_ChIP-ChIP_LS174T_Human0.74645541
88KAP1_27257070_Chip-Seq_ESCs_Mouse0.74561191
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.74350277
90TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74292372
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74245382
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.73929182
93JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73913546
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72674802
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.71720766
96AR_20517297_ChIP-Seq_VCAP_Human0.71483596
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.70790848
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.70387863
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70296642
100RARB_24833708_ChIP-Seq_LIVER_Mouse0.70221541
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.70007867
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69902024
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68977820
104FOXA1_25552417_ChIP-Seq_VCAP_Human0.67842092
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.67600539
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.67464435
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.66597858
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66154053
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.65575620
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65098162
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64835489
112GATA6_25053715_ChIP-Seq_YYC3_Human0.64789844
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.62515412
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61050329
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60600328
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59760050
117SOX2_20726797_ChIP-Seq_SW620_Human0.59390970
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56968905
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.55782324
120* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55650516
121* CEBPB_22108803_ChIP-Seq_LS180_Human0.55307887
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.54665662
123P53_21459846_ChIP-Seq_SAOS-2_Human0.54543865
124ERG_20517297_ChIP-Seq_VCAP_Human0.53199295
125ESET_19884257_ChIP-Seq_ESCs_Mouse0.52317030
126EGR1_19032775_ChIP-ChIP_M12_Human0.52106597
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.50612676
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.50612676
129LXR_22292898_ChIP-Seq_THP-1_Human0.50202502
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49484800
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.49410386
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.48858764
133* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48442750
134MYC_19915707_ChIP-ChIP_AK7_Human0.48071182
135ZNF263_19887448_ChIP-Seq_K562_Human0.46994456
136STAT1_17558387_ChIP-Seq_HELA_Human0.46242474
137CBP_21632823_ChIP-Seq_H3396_Human0.45026953
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.44876946
139TAF2_19829295_ChIP-Seq_ESCs_Human0.44339190
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.44236001
141GATA1_19941826_ChIP-Seq_K562_Human0.42941497
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.40726631
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.40455858
144GATA2_19941826_ChIP-Seq_K562_Human0.40189829
145CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38598772
146EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.38101185
147* SPI1_26923725_Chip-Seq_HPCs_Mouse0.37364970
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36654790
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.36552346
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.36541751
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.36021291
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.35665110
153P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.35655387
154PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.35074945
155STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.34751221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.86870741
2MP0005360_urolithiasis7.17966918
3MP0005085_abnormal_gallbladder_physiolo6.42492599
4MP0005365_abnormal_bile_salt6.34230143
5MP0008875_abnormal_xenobiotic_pharmacok4.67023092
6MP0003806_abnormal_nucleotide_metabolis4.15885253
7MP0003252_abnormal_bile_duct3.86100175
8MP0005083_abnormal_biliary_tract3.45969926
9MP0010329_abnormal_lipoprotein_level3.45841797
10MP0001666_abnormal_nutrient_absorption3.26618131
11MP0009840_abnormal_foam_cell3.02483056
12MP0003195_calcinosis2.87065712
13MP0005332_abnormal_amino_acid2.67677481
14MP0003868_abnormal_feces_composition2.55608557
15MP0000566_synostosis2.41432997
16MP0003191_abnormal_cellular_cholesterol2.36499051
17MP0002138_abnormal_hepatobiliary_system2.20611287
18MP0004019_abnormal_vitamin_homeostasis2.17210984
19MP0000609_abnormal_liver_physiology2.11976180
20MP0002118_abnormal_lipid_homeostasis2.08599736
21MP0003183_abnormal_peptide_metabolism1.89736972
22MP0003941_abnormal_skin_development1.76284798
23MP0005319_abnormal_enzyme/_coenzyme1.76111905
24MP0001764_abnormal_homeostasis1.73855222
25MP0009697_abnormal_copulation1.55369814
26MP0002089_abnormal_postnatal_growth/wei1.53233597
27MP0005220_abnormal_exocrine_pancreas1.45650722
28MP0005584_abnormal_enzyme/coenzyme_acti1.42071481
29MP0009643_abnormal_urine_homeostasis1.36212552
30MP0003011_delayed_dark_adaptation1.32965112
31MP0005084_abnormal_gallbladder_morpholo1.32111977
32MP0003186_abnormal_redox_activity1.30814968
33MP0003693_abnormal_embryo_hatching1.26876064
34MP0005451_abnormal_body_composition1.26277393
35MP0003656_abnormal_erythrocyte_physiolo1.26016672
36MP0004147_increased_porphyrin_level1.23637453
37MP0004185_abnormal_adipocyte_glucose1.20188413
38MP0000678_abnormal_parathyroid_gland1.17704490
39MP0000598_abnormal_liver_morphology1.17683492
40MP0002938_white_spotting1.13901835
41MP0005636_abnormal_mineral_homeostasis1.07465504
42MP0003890_abnormal_embryonic-extraembry1.03665016
43MP0004957_abnormal_blastocyst_morpholog1.02780704
44MP0000462_abnormal_digestive_system0.98799644
45MP0003283_abnormal_digestive_organ0.98548337
46MP0003122_maternal_imprinting0.98089887
47MP0005647_abnormal_sex_gland0.97561411
48MP0009763_increased_sensitivity_to0.96416835
49MP0003705_abnormal_hypodermis_morpholog0.95989769
50MP0003567_abnormal_fetal_cardiomyocyte0.95773400
51MP0002078_abnormal_glucose_homeostasis0.95465745
52MP0009764_decreased_sensitivity_to0.94827844
53MP0004133_heterotaxia0.93213508
54MP0008469_abnormal_protein_level0.91459978
55MP0009642_abnormal_blood_homeostasis0.91063565
56MP0005646_abnormal_pituitary_gland0.89913624
57MP0002254_reproductive_system_inflammat0.87613363
58MP0005408_hypopigmentation0.87364924
59MP0005670_abnormal_white_adipose0.87229058
60MP0010368_abnormal_lymphatic_system0.86007243
61MP0002876_abnormal_thyroid_physiology0.85883750
62MP0000013_abnormal_adipose_tissue0.85792969
63MP0006036_abnormal_mitochondrial_physio0.85197540
64MP0003123_paternal_imprinting0.84309293
65MP0000477_abnormal_intestine_morphology0.82763435
66MP0004264_abnormal_extraembryonic_tissu0.82533182
67MP0000490_abnormal_crypts_of0.82449437
68MP0009765_abnormal_xenobiotic_induced0.79653978
69MP0003119_abnormal_digestive_system0.77893348
70MP0005376_homeostasis/metabolism_phenot0.75953761
71MP0001730_embryonic_growth_arrest0.75197179
72MP0010352_gastrointestinal_tract_polyps0.73726345
73MP0000604_amyloidosis0.73608042
74MP0005334_abnormal_fat_pad0.72369073
75MP0005448_abnormal_energy_balance0.68532354
76MP0002697_abnormal_eye_size0.68431051
77MP0003315_abnormal_perineum_morphology0.67746702
78MP0001664_abnormal_digestion0.67320305
79MP0001756_abnormal_urination0.67114319
80MP0002249_abnormal_larynx_morphology0.67076090
81MP0001944_abnormal_pancreas_morphology0.66841554
82MP0002928_abnormal_bile_duct0.65419647
83MP0005535_abnormal_body_temperature0.64482470
84MP0002971_abnormal_brown_adipose0.64366636
85MP0005381_digestive/alimentary_phenotyp0.64323341
86MP0003111_abnormal_nucleus_morphology0.63508501
87MP0000003_abnormal_adipose_tissue0.62470395
88MP0009379_abnormal_foot_pigmentation0.61717377
89MP0005266_abnormal_metabolism0.61303946
90MP0000639_abnormal_adrenal_gland0.57325107
91MP0002693_abnormal_pancreas_physiology0.56244104
92MP0003953_abnormal_hormone_level0.55490114
93MP0001661_extended_life_span0.54549706
94MP0005464_abnormal_platelet_physiology0.50008682
95MP0004043_abnormal_pH_regulation0.49766269
96MP0005377_hearing/vestibular/ear_phenot0.49513355
97MP0003878_abnormal_ear_physiology0.49513355
98MP0003638_abnormal_response/metabolism_0.49390911
99MP0006035_abnormal_mitochondrial_morpho0.49081296
100MP0001915_intracranial_hemorrhage0.48784711
101MP0009053_abnormal_anal_canal0.46964661
102MP0010155_abnormal_intestine_physiology0.46348746
103MP0002136_abnormal_kidney_physiology0.46063628
104MP0002233_abnormal_nose_morphology0.45931610
105MP0010234_abnormal_vibrissa_follicle0.45395641
106MP0004130_abnormal_muscle_cell0.44355475
107MP0005367_renal/urinary_system_phenotyp0.44221902
108MP0000516_abnormal_urinary_system0.44221902
109MP0009384_cardiac_valve_regurgitation0.44139558
110MP0002086_abnormal_extraembryonic_tissu0.42965812
111MP0001849_ear_inflammation0.42844126
112MP0003436_decreased_susceptibility_to0.42304565
113MP0003937_abnormal_limbs/digits/tail_de0.42144312
114MP0004782_abnormal_surfactant_physiolog0.42089480
115MP0003724_increased_susceptibility_to0.41568056
116MP0003959_abnormal_lean_body0.41338574
117MP0002909_abnormal_adrenal_gland0.40585877
118MP0002111_abnormal_tail_morphology0.40148410
119MP0005395_other_phenotype0.39962818
120MP0002837_dystrophic_cardiac_calcinosis0.39770790
121MP0003718_maternal_effect0.39490065
122MP0005666_abnormal_adipose_tissue0.38704437
123MP0000579_abnormal_nail_morphology0.38012359
124MP0001845_abnormal_inflammatory_respons0.37682787
125MP0008873_increased_physiological_sensi0.37443529
126MP0005166_decreased_susceptibility_to0.36158103
127MP0003300_gastrointestinal_ulcer0.34987353
128MP0002796_impaired_skin_barrier0.34307096
129MP0002132_abnormal_respiratory_system0.34178015
130MP0002060_abnormal_skin_morphology0.33539058
131MP0008004_abnormal_stomach_pH0.32579734
132MP0002970_abnormal_white_adipose0.32151937
133MP0009672_abnormal_birth_weight0.31997491
134MP0000230_abnormal_systemic_arterial0.31926480
135MP0005248_abnormal_Harderian_gland0.31867314
136MP0003690_abnormal_glial_cell0.31544979
137MP0001765_abnormal_ion_homeostasis0.30475664
138MP0004381_abnormal_hair_follicle0.30109354
139MP0002822_catalepsy0.29917295
140MP0001243_abnormal_dermal_layer0.28922089
141MP0001663_abnormal_digestive_system0.27831244
142MP0008872_abnormal_physiological_respon0.27716618
143MP0001873_stomach_inflammation0.27571865

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.50107353
2Intrahepatic cholestasis (HP:0001406)7.14742548
3Deep venous thrombosis (HP:0002625)6.83943873
4Prolonged partial thromboplastin time (HP:0003645)6.49762305
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.45160554
6Hypobetalipoproteinemia (HP:0003563)6.05290940
7Xanthomatosis (HP:0000991)5.97413114
8Complement deficiency (HP:0004431)5.27327817
9Hyperlipoproteinemia (HP:0010980)5.18514750
10Abnormality of the common coagulation pathway (HP:0010990)4.66035185
11Joint hemorrhage (HP:0005261)4.60957696
12Hypolipoproteinemia (HP:0010981)4.58789606
13Hypoglycemic coma (HP:0001325)4.45052155
14Hyperammonemia (HP:0001987)4.41762308
15Fat malabsorption (HP:0002630)4.36117329
16Ketosis (HP:0001946)4.34540865
17Hyperglycinemia (HP:0002154)4.31739938
18Abnormality of the intrinsic pathway (HP:0010989)4.22561699
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19837502
20Epidermoid cyst (HP:0200040)4.17638033
21Abnormality of methionine metabolism (HP:0010901)4.15195018
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.11808851
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.07829696
24Hypoalphalipoproteinemia (HP:0003233)4.02982155
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.99211088
26Conjugated hyperbilirubinemia (HP:0002908)3.93920941
27Abnormality of complement system (HP:0005339)3.88255743
28Hyperglycinuria (HP:0003108)3.74837088
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.71707908
30Abnormality of alanine metabolism (HP:0010916)3.71707908
31Hyperalaninemia (HP:0003348)3.71707908
32Abnormality of serine family amino acid metabolism (HP:0010894)3.67977920
33Abnormality of glycine metabolism (HP:0010895)3.67977920
34Abnormality of pyrimidine metabolism (HP:0004353)3.55245001
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45929153
36Steatorrhea (HP:0002570)3.31154528
37Hypercholesterolemia (HP:0003124)3.29297660
38Hypoglycemic seizures (HP:0002173)3.28769602
39Hyperbilirubinemia (HP:0002904)3.28104753
40Ketoacidosis (HP:0001993)3.26654372
41Abnormality of fatty-acid metabolism (HP:0004359)3.26001002
42Spontaneous abortion (HP:0005268)3.10092924
43Abnormality of nucleobase metabolism (HP:0010932)3.03723213
44Abnormality of serum amino acid levels (HP:0003112)2.96763223
45Megaloblastic anemia (HP:0001889)2.93489228
46Hepatocellular carcinoma (HP:0001402)2.84132328
47Hyperinsulinemic hypoglycemia (HP:0000825)2.80150551
48Gout (HP:0001997)2.78588978
49Abnormality of purine metabolism (HP:0004352)2.77962319
50Delayed CNS myelination (HP:0002188)2.76875680
51Metabolic acidosis (HP:0001942)2.75661220
52Hemorrhage of the eye (HP:0011885)2.75060151
53Ileus (HP:0002595)2.73836488
54Lethargy (HP:0001254)2.65986315
55Dicarboxylic aciduria (HP:0003215)2.64390930
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64390930
57Myocardial infarction (HP:0001658)2.64370706
58Late onset (HP:0003584)2.63014774
59Abnormality of carpal bone ossification (HP:0006257)2.62886954
60Skin nodule (HP:0200036)2.60231789
61Flat acetabular roof (HP:0003180)2.59447630
62Abnormality of homocysteine metabolism (HP:0010919)2.58149530
63Homocystinuria (HP:0002156)2.58149530
64Acanthocytosis (HP:0001927)2.57878934
65Hypochromic microcytic anemia (HP:0004840)2.56401608
66Systemic lupus erythematosus (HP:0002725)2.54751951
67Hyperphosphaturia (HP:0003109)2.53931607
68Symptomatic seizures (HP:0011145)2.48752363
69Proximal tubulopathy (HP:0000114)2.46362123
70Vascular calcification (HP:0004934)2.44809768
71Glycosuria (HP:0003076)2.44669739
72Abnormality of urine glucose concentration (HP:0011016)2.44669739
73Cerebral edema (HP:0002181)2.43234873
74Hyperuricemia (HP:0002149)2.41794858
75Generalized aminoaciduria (HP:0002909)2.37641863
76Irritability (HP:0000737)2.36557966
77Increased serum pyruvate (HP:0003542)2.35784550
78Pancreatitis (HP:0001733)2.34915414
79Recurrent gram-negative bacterial infections (HP:0005420)2.30755718
80Abnormal gallbladder morphology (HP:0012437)2.30375313
81Gingival bleeding (HP:0000225)2.30113369
82Enlarged kidneys (HP:0000105)2.28879446
83Amyloidosis (HP:0011034)2.26959087
84Hyperglycemia (HP:0003074)2.25227039
85Malnutrition (HP:0004395)2.24493912
86Congenital sensorineural hearing impairment (HP:0008527)2.24356872
87Glomerulonephritis (HP:0000099)2.23012579
88Menorrhagia (HP:0000132)2.19900863
89Widely patent fontanelles and sutures (HP:0004492)2.19823177
90Pigmentary retinal degeneration (HP:0001146)2.18316817
91Cholelithiasis (HP:0001081)2.18112278
92Osteomalacia (HP:0002749)2.17065425
93Esophageal varix (HP:0002040)2.13941181
94Abnormal urine phosphate concentration (HP:0012599)2.12440871
95Cardiovascular calcification (HP:0011915)2.12016208
96Abnormality of glycolysis (HP:0004366)2.11974351
97Cholecystitis (HP:0001082)2.10316970
98Abnormal gallbladder physiology (HP:0012438)2.10316970
99Neonatal onset (HP:0003623)2.08398133
100Brushfield spots (HP:0001088)2.08377739
101Abnormality of alkaline phosphatase activity (HP:0004379)2.07850154
102Pulmonary embolism (HP:0002204)2.07727896
103Spastic diplegia (HP:0001264)2.06945718
104Vaginal fistula (HP:0004320)2.05299785
105Abnormal tarsal ossification (HP:0008369)2.04920764
106Mitral stenosis (HP:0001718)2.04811823
107Nephritis (HP:0000123)2.03827799
108Vomiting (HP:0002013)2.03506521
109Thrombophlebitis (HP:0004418)2.01408311
110Anorexia (HP:0002039)1.99022213
111Abnormal umbilical cord blood vessels (HP:0011403)1.98953689
112Single umbilical artery (HP:0001195)1.98953689
113Abnormality of the fetal cardiovascular system (HP:0010948)1.98953689
114Sensorimotor neuropathy (HP:0007141)1.98387344
115Hypophosphatemic rickets (HP:0004912)1.96617559
116Abnormality of endocrine pancreas physiology (HP:0012093)1.96354261
117Abnormality of the pancreatic islet cells (HP:0006476)1.96354261
118Opisthotonus (HP:0002179)1.96213197
119Rickets (HP:0002748)1.94336009
120Abnormal enzyme/coenzyme activity (HP:0012379)1.92900329
121Prenatal maternal abnormality (HP:0002686)1.92753393
122Renal cortical cysts (HP:0000803)1.92721437
123Nausea (HP:0002018)1.92020400
124Abnormality of vitamin metabolism (HP:0100508)1.91451935
125Protuberant abdomen (HP:0001538)1.90701251
126Elevated alkaline phosphatase (HP:0003155)1.90195951
127Abnormal cartilage morphology (HP:0002763)1.89751758
128Abnormality of the gallbladder (HP:0005264)1.88936751
129Hemangiomatosis (HP:0007461)1.88900137
130Abnormality of the vitamin B12 metabolism (HP:0004341)1.88299838
131Visceral angiomatosis (HP:0100761)1.88169776
132Abnormality of vitamin B metabolism (HP:0004340)1.87883866
133Elevated hepatic transaminases (HP:0002910)1.87437028
134Hydroxyprolinuria (HP:0003080)1.86942640
135Abnormality of proline metabolism (HP:0010907)1.86942640
136Abnormality of transition element cation homeostasis (HP:0011030)1.86644722
137Poikilocytosis (HP:0004447)1.86449625
138Reduced antithrombin III activity (HP:0001976)1.86114600
139Abnormal hand bone ossification (HP:0010660)1.86105600
140Increased purine levels (HP:0004368)1.84852343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.01068232
2ERN14.75517432
3INSRR4.16943954
4FGFR44.03680427
5ACVR1B3.67992222
6SIK13.54550601
7TAOK33.35630269
8SMG13.17629904
9ERBB43.16677531
10LMTK23.09488734
11FRK3.00564643
12NEK12.41809331
13MST1R2.33948088
14FLT32.27129297
15VRK22.07709330
16TTK1.97859990
17MAPK151.93662557
18PKN21.89202438
19MAPK111.85501311
20NME11.81360240
21FGR1.81126759
22PIK3CG1.80585844
23CDK91.79176821
24RPS6KB21.76920265
25MAP3K31.62224565
26PTK61.60321276
27TRIB31.56576120
28IRAK31.54464778
29CDC71.53922611
30STK38L1.52199008
31MAP2K41.50265503
32MST41.50178821
33TAF11.43310429
34FGFR11.42775104
35LATS11.39417867
36ICK1.39204448
37EEF2K1.27847764
38STK161.26804087
39EPHA31.25932268
40SGK4941.23910492
41SGK2231.23910492
42NEK91.23346581
43CDK121.22512674
44TYK21.18889577
45PAK41.18684999
46MAP3K111.13189929
47BUB11.10639017
48MAP2K21.09193906
49CDK71.08644275
50BRSK21.05780578
51WNK41.05405864
52PRKAA21.03538070
53JAK21.02441176
54TYRO31.00919888
55ABL21.00511983
56ERBB20.99825809
57MET0.96103252
58STK240.95462763
59DYRK20.94834785
60TBK10.93440945
61TNIK0.91468113
62MAP3K140.89835014
63MAP2K60.89822345
64DYRK1B0.88662584
65DAPK20.87096573
66MAP3K70.83331062
67KDR0.82947758
68JAK10.79600644
69GRK60.77909487
70EPHB10.77465318
71PINK10.73954968
72PRKCI0.73945805
73NLK0.72902124
74BMX0.72809748
75EPHB20.72668696
76NUAK10.72302170
77MAP2K30.70373573
78PLK40.70013970
79PRKG20.69919425
80FGFR20.69725647
81MAPK40.69649610
82GRK10.68228927
83CSNK1E0.67722950
84TSSK60.66192202
85PRKAA10.65929129
86STK390.65812534
87EPHA20.65685525
88CAMK2G0.64431138
89RIPK10.63631727
90GSK3A0.63213831
91PRKACG0.63090684
92PRKCZ0.62570775
93PTK20.62260436
94PLK30.61538811
95BRSK10.60085030
96MAP3K10.59010377
97MAP3K20.58685002
98CSNK1A10.58298672
99CHEK20.58205030
100IRAK10.57060768
101MAP3K100.55951250
102MAP3K80.55940930
103OXSR10.55617026
104TIE10.55571871
105SGK20.55168913
106CSK0.55157243
107MAP2K10.54953714
108TGFBR20.54155791
109CSNK2A10.53921754
110FGFR30.53063814
111CSNK2A20.51521871
112STK40.51242893
113STK30.51029685
114PDGFRA0.50834988
115PIK3CA0.50750594
116MATK0.49546656
117PLK10.48695466
118NEK20.48373883
119SRPK10.44928051
120ALK0.44469008
121MAPK120.44407923
122SGK10.42266098
123EIF2AK30.41422295
124IKBKE0.40588408
125BRD40.40335372
126WNK30.39679420
127ZAK0.39520768
128CDK60.39081602
129AKT20.38994033
130PDK20.38574895
131NTRK30.37733153
132AURKA0.37403147
133IGF1R0.36973878
134PDPK10.36262098
135MAPK70.35429734
136SGK30.31596423
137PRKCQ0.31030823
138CSNK1G10.30694379
139CAMK1D0.30503772
140PBK0.29864339
141PASK0.28622708
142MTOR0.26844921
143MAP3K50.26257565
144CHUK0.25401733
145NME20.24865852
146CDK40.23854442
147PRKCA0.23052483
148ZAP700.22985753
149MAPK30.22894207
150RET0.22589541
151JAK30.22273083
152AKT30.21829424
153CSF1R0.20294550
154PDK10.19795541
155PRKCG0.16503954
156TGFBR10.16077794
157FER0.15716418
158EGFR0.15349525
159RPS6KB10.15288740

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45531157
2Nitrogen metabolism_Homo sapiens_hsa009103.46473751
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24954340
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17925806
5Arginine biosynthesis_Homo sapiens_hsa002202.98325704
6Complement and coagulation cascades_Homo sapiens_hsa046102.76368145
7Tryptophan metabolism_Homo sapiens_hsa003802.69211166
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58789538
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53885149
10Fatty acid degradation_Homo sapiens_hsa000712.44106336
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42539044
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37894159
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18272613
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06032166
15Peroxisome_Homo sapiens_hsa041462.05757953
16Butanoate metabolism_Homo sapiens_hsa006502.02391613
17Histidine metabolism_Homo sapiens_hsa003401.94674810
18Selenocompound metabolism_Homo sapiens_hsa004501.86384729
19Propanoate metabolism_Homo sapiens_hsa006401.86206980
20Chemical carcinogenesis_Homo sapiens_hsa052041.84686142
21* Maturity onset diabetes of the young_Homo sapiens_hsa049501.83113963
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80702645
23PPAR signaling pathway_Homo sapiens_hsa033201.77346065
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.75162360
25Sulfur metabolism_Homo sapiens_hsa009201.74787987
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.70321054
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68019005
28beta-Alanine metabolism_Homo sapiens_hsa004101.65296554
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63813542
30Fatty acid metabolism_Homo sapiens_hsa012121.63770093
31Folate biosynthesis_Homo sapiens_hsa007901.62238939
32Staphylococcus aureus infection_Homo sapiens_hsa051501.61691920
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59742739
34Fat digestion and absorption_Homo sapiens_hsa049751.59575607
35Retinol metabolism_Homo sapiens_hsa008301.58455714
36Caffeine metabolism_Homo sapiens_hsa002321.55835725
37Phenylalanine metabolism_Homo sapiens_hsa003601.54260561
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41674988
39Bile secretion_Homo sapiens_hsa049761.41614054
40Tyrosine metabolism_Homo sapiens_hsa003501.39760763
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37334887
42Starch and sucrose metabolism_Homo sapiens_hsa005001.36014925
43Pyruvate metabolism_Homo sapiens_hsa006201.31228475
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.29694106
45Steroid biosynthesis_Homo sapiens_hsa001001.24659477
46Fatty acid elongation_Homo sapiens_hsa000621.21019689
47ABC transporters_Homo sapiens_hsa020101.17255670
48Biosynthesis of amino acids_Homo sapiens_hsa012301.16622513
49Carbon metabolism_Homo sapiens_hsa012001.06580362
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.06006095
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05348144
52Vitamin digestion and absorption_Homo sapiens_hsa049771.05029972
53Arginine and proline metabolism_Homo sapiens_hsa003301.04775235
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99961133
55Sulfur relay system_Homo sapiens_hsa041220.97486620
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92884327
57Vitamin B6 metabolism_Homo sapiens_hsa007500.91816405
58Mineral absorption_Homo sapiens_hsa049780.80180544
59One carbon pool by folate_Homo sapiens_hsa006700.77712308
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75579778
61Lysine degradation_Homo sapiens_hsa003100.75227333
62Glycerolipid metabolism_Homo sapiens_hsa005610.73682956
63Glutathione metabolism_Homo sapiens_hsa004800.72099811
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67477153
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67434160
66Pentose phosphate pathway_Homo sapiens_hsa000300.59518171
67Metabolic pathways_Homo sapiens_hsa011000.52542945
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51883905
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50468069
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45148340
71Galactose metabolism_Homo sapiens_hsa000520.45006577
72Fructose and mannose metabolism_Homo sapiens_hsa000510.42165910
73Linoleic acid metabolism_Homo sapiens_hsa005910.40420681
74Prion diseases_Homo sapiens_hsa050200.38595877
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32397400
76Protein export_Homo sapiens_hsa030600.30021699
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29735451
78Fatty acid biosynthesis_Homo sapiens_hsa000610.28159934
79Sphingolipid metabolism_Homo sapiens_hsa006000.25459119
80Insulin resistance_Homo sapiens_hsa049310.24940668
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.19190580
82Proteasome_Homo sapiens_hsa030500.16966324
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16749669
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.15554823
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14156953
86Glucagon signaling pathway_Homo sapiens_hsa049220.12019333
87Ribosome_Homo sapiens_hsa030100.11451921
88DNA replication_Homo sapiens_hsa030300.10734529
89Base excision repair_Homo sapiens_hsa034100.10723006
90Vibrio cholerae infection_Homo sapiens_hsa051100.09723807
91Protein digestion and absorption_Homo sapiens_hsa049740.09027560
92Tight junction_Homo sapiens_hsa045300.08963346
93Spliceosome_Homo sapiens_hsa030400.07519379
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.06976031
95Thyroid cancer_Homo sapiens_hsa052160.06641472
96mRNA surveillance pathway_Homo sapiens_hsa030150.06390519
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05761869
98Arachidonic acid metabolism_Homo sapiens_hsa005900.00532022
99Regulation of autophagy_Homo sapiens_hsa041400.00410405
100Ether lipid metabolism_Homo sapiens_hsa00565-0.1678492
101Other glycan degradation_Homo sapiens_hsa00511-0.1570273
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1475865
103N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1466374
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1246284
105Insulin signaling pathway_Homo sapiens_hsa04910-0.1243378
106Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1223801
107Hepatitis C_Homo sapiens_hsa05160-0.1159719
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1061293
109Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1011890
110Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0969825
111Renin-angiotensin system_Homo sapiens_hsa04614-0.0922495
112Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0738262
113Pancreatic secretion_Homo sapiens_hsa04972-0.0151346
114AMPK signaling pathway_Homo sapiens_hsa04152-0.0087604

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