FOXC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)7.30401067
2glomerular basement membrane development (GO:0032836)6.83772460
3glomerular epithelial cell development (GO:0072310)6.35004616
4outer ear morphogenesis (GO:0042473)5.84435348
5chondrocyte proliferation (GO:0035988)5.38122093
6paraxial mesoderm development (GO:0048339)5.14461243
7kidney mesenchyme development (GO:0072074)5.00347285
8metanephric mesenchyme development (GO:0072075)4.82191118
9lymph vessel development (GO:0001945)4.75757668
10glomerulus development (GO:0032835)4.62504860
11substrate-dependent cell migration (GO:0006929)4.60447603
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.59310686
13mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.28561819
14negative regulation of chondrocyte differentiation (GO:0032331)4.23975398
15negative regulation of nitric-oxide synthase activity (GO:0051001)4.16382550
16wound healing, spreading of epidermal cells (GO:0035313)4.12142001
17cell adhesion mediated by integrin (GO:0033627)4.09813173
18cell-substrate junction assembly (GO:0007044)3.99012261
19coronary vasculature morphogenesis (GO:0060977)3.82559240
20positive regulation of epithelial to mesenchymal transition (GO:0010718)3.80994964
21facial nerve structural organization (GO:0021612)3.80882169
22vascular endothelial growth factor signaling pathway (GO:0038084)3.80708009
23sequestering of extracellular ligand from receptor (GO:0035581)3.72604680
24membrane raft organization (GO:0031579)3.69152050
25protein heterotrimerization (GO:0070208)3.66433660
26* positive regulation of blood vessel endothelial cell migration (GO:0043536)3.64516814
27positive regulation of endothelial cell apoptotic process (GO:2000353)3.64516644
28actin filament depolymerization (GO:0030042)3.62860092
29mesodermal cell differentiation (GO:0048333)3.58477741
30sprouting angiogenesis (GO:0002040)3.57198112
31cell migration involved in heart development (GO:0060973)3.56862722
32* regulation of heart morphogenesis (GO:2000826)3.56102066
33* collagen fibril organization (GO:0030199)3.52908127
34axon extension involved in axon guidance (GO:0048846)3.49838116
35neuron projection extension involved in neuron projection guidance (GO:1902284)3.49838116
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.49072953
37endothelial cell morphogenesis (GO:0001886)3.48720407
38endocardial cushion development (GO:0003197)3.48416657
39hippo signaling (GO:0035329)3.46855588
40protein retention in ER lumen (GO:0006621)3.44073939
41cell migration involved in sprouting angiogenesis (GO:0002042)3.40485703
42regulation of integrin-mediated signaling pathway (GO:2001044)3.39891102
43venous blood vessel morphogenesis (GO:0048845)3.37943683
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.36735233
45dermatan sulfate biosynthetic process (GO:0030208)3.36598844
46mesenchymal to epithelial transition (GO:0060231)3.35531590
47pattern specification involved in kidney development (GO:0061004)3.34656197
48COPI coating of Golgi vesicle (GO:0048205)3.33509060
49Golgi transport vesicle coating (GO:0048200)3.33509060
50endodermal cell differentiation (GO:0035987)3.33366065
51hemidesmosome assembly (GO:0031581)3.32673509
52regulation of plasminogen activation (GO:0010755)3.32284796
53cell proliferation involved in metanephros development (GO:0072203)3.30838720
54positive regulation of cartilage development (GO:0061036)3.29781752
55extracellular matrix assembly (GO:0085029)3.29028482
56mesenchyme development (GO:0060485)3.28980941
57lung vasculature development (GO:0060426)3.28751086
58collagen metabolic process (GO:0032963)3.27182600
59negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.26186084
60polarized epithelial cell differentiation (GO:0030859)3.25257623
61blood vessel maturation (GO:0001955)3.25122674
62positive regulation of osteoblast proliferation (GO:0033690)3.22407577
63regulation of cartilage development (GO:0061035)3.20514327
64chondroitin sulfate biosynthetic process (GO:0030206)3.19977630
65extracellular fibril organization (GO:0043206)3.19799654
66heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.19706473
67G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.19185296
68dermatan sulfate metabolic process (GO:0030205)3.18240102
69negative regulation of axon extension involved in axon guidance (GO:0048843)3.17941222
70adherens junction assembly (GO:0034333)3.14690325
71* neural crest cell development (GO:0014032)3.14581724
72chondrocyte development (GO:0002063)3.12826946
73negative regulation of cartilage development (GO:0061037)3.12722401
74type B pancreatic cell proliferation (GO:0044342)3.11925000
75germ cell migration (GO:0008354)3.11697022
76organ induction (GO:0001759)3.11672299
77cell-substrate adherens junction assembly (GO:0007045)3.10417523
78focal adhesion assembly (GO:0048041)3.10417523
79extracellular matrix disassembly (GO:0022617)3.10287608
80positive regulation of extracellular matrix organization (GO:1903055)3.10274367
81barbed-end actin filament capping (GO:0051016)3.09827121
82retina vasculature morphogenesis in camera-type eye (GO:0061299)3.07962555
83positive regulation of fibroblast migration (GO:0010763)3.07648259
84regulation of transforming growth factor beta2 production (GO:0032909)3.07356099
85apoptotic cell clearance (GO:0043277)3.06562881
86* artery morphogenesis (GO:0048844)3.03822673
87negative regulation of stem cell proliferation (GO:2000647)3.01032156
88collagen catabolic process (GO:0030574)3.00407784
89regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.00240583
90regulation of chondrocyte differentiation (GO:0032330)3.00055774
91* mesonephric tubule development (GO:0072164)2.99906100
92negative regulation of embryonic development (GO:0045992)2.99896624
93cranial nerve structural organization (GO:0021604)2.99066733
94craniofacial suture morphogenesis (GO:0097094)2.98866481
95wound healing, spreading of cells (GO:0044319)2.98255002
96multicellular organismal macromolecule metabolic process (GO:0044259)2.97068372
97embryonic skeletal joint morphogenesis (GO:0060272)2.96058298
98* lymphangiogenesis (GO:0001946)2.95476558
99* positive regulation of endothelial cell migration (GO:0010595)2.95462440
100positive regulation of axon extension (GO:0045773)2.94882037
101* extracellular matrix organization (GO:0030198)2.94736742
102respiratory tube development (GO:0030323)2.94679694
103atrioventricular valve morphogenesis (GO:0003181)2.94479497
104protein localization to endosome (GO:0036010)2.94340099
105basement membrane organization (GO:0071711)2.93916534
106peptidyl-proline hydroxylation (GO:0019511)2.93811759
107* extracellular structure organization (GO:0043062)2.93762205
108renal filtration (GO:0097205)2.93665384
109protein hydroxylation (GO:0018126)2.93361297
110response to gravity (GO:0009629)2.93184050
111negative regulation of DNA repair (GO:0045738)2.92761439
112* ureteric bud development (GO:0001657)2.92544066
113cellular response to vitamin (GO:0071295)2.92330161
114notochord development (GO:0030903)2.91899630
115cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.91612764
116proximal/distal pattern formation (GO:0009954)2.91301660
117* mesonephric epithelium development (GO:0072163)2.91264823
118mesenchyme morphogenesis (GO:0072132)2.90186190
119regulation of organ formation (GO:0003156)2.89901675
120mesenchymal-epithelial cell signaling (GO:0060638)2.89844983
121stress fiber assembly (GO:0043149)2.89756962
122middle ear morphogenesis (GO:0042474)2.89669993
123regulation of metalloenzyme activity (GO:0048552)2.87694683
124* mesenchymal cell development (GO:0014031)2.87425494
125positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.87367705
126regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.87244120
127embryonic cranial skeleton morphogenesis (GO:0048701)2.86131430
128negative regulation of anoikis (GO:2000811)2.85656060
129negative regulation of fatty acid transport (GO:2000192)2.85109272
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.84250168
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.82426357
132peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.81849077
133multicellular organismal metabolic process (GO:0044236)2.80771693
134artery development (GO:0060840)2.78871556
135cell proliferation involved in kidney development (GO:0072111)2.78427760
136cranial suture morphogenesis (GO:0060363)2.77695012
137plasma membrane repair (GO:0001778)2.76993393
138* vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76504198
139regulation of SMAD protein import into nucleus (GO:0060390)2.75888992
140negative regulation of BMP signaling pathway (GO:0030514)2.75334637
141negative regulation of smooth muscle cell migration (GO:0014912)2.75042054
142positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.74996851
143regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74761584
144positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.74369044
145cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.73372376
146muscle cell fate commitment (GO:0042693)2.72522518
147* blood vessel morphogenesis (GO:0048514)2.72394963
148aorta morphogenesis (GO:0035909)2.72223895
149regulation of tight junction assembly (GO:2000810)2.71734301
150mesoderm formation (GO:0001707)2.71565855
151blood vessel endothelial cell migration (GO:0043534)2.69423104
152cochlea morphogenesis (GO:0090103)2.68738423
153smooth muscle tissue development (GO:0048745)2.67846873
154endothelial cell chemotaxis (GO:0035767)2.66548624
155positive regulation of stem cell differentiation (GO:2000738)2.65749243
156bone trabecula formation (GO:0060346)2.63907893
157skin morphogenesis (GO:0043589)2.63505124
158Notch signaling involved in heart development (GO:0061314)2.63453233
159substrate adhesion-dependent cell spreading (GO:0034446)2.61631228
160positive regulation of mesenchymal cell proliferation (GO:0002053)2.60983991
161regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60812926
162epithelial cell-cell adhesion (GO:0090136)2.59513278
163mesenchymal cell differentiation involved in kidney development (GO:0072161)2.58706151
164mesenchymal cell differentiation involved in renal system development (GO:2001012)2.58706151
165glomerular filtration (GO:0003094)2.56233376
166positive regulation of SMAD protein import into nucleus (GO:0060391)2.54529342
167positive regulation of metanephros development (GO:0072216)2.53311993
168branching involved in salivary gland morphogenesis (GO:0060445)2.53206941
169embryonic foregut morphogenesis (GO:0048617)2.53178215
170epithelial to mesenchymal transition (GO:0001837)2.52372072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.51865509
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.29693124
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.20609699
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.12811521
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.68021096
6CLOCK_20551151_ChIP-Seq_293T_Human3.26743729
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.16349395
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.12778499
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91436122
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.83474078
11WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.66549512
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.48571407
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.46485084
14AR_21909140_ChIP-Seq_LNCAP_Human2.41655104
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.40749204
16* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.40698657
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36781088
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.22151436
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15815521
20E2F7_22180533_ChIP-Seq_HELA_Human2.14628386
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.11328736
22* ELK3_25401928_ChIP-Seq_HUVEC_Human2.09874205
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09651724
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09218999
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.06219594
26HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05220554
27BRD4_25478319_ChIP-Seq_HGPS_Human2.03402134
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93836068
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83444694
30* TP53_20018659_ChIP-ChIP_R1E_Mouse1.82376709
31JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80673327
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.77621533
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.74170456
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.72769203
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.69189231
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66841278
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64988747
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.64236381
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60658574
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.59704781
41* EED_16625203_ChIP-ChIP_MESCs_Mouse1.57488987
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57357534
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55707598
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53211345
45CJUN_26792858_Chip-Seq_BT549_Human1.51935164
46* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51523172
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50995560
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50995560
49UBF1/2_26484160_Chip-Seq_HMECs_Human1.50363990
50* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49221069
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48124946
52TP53_18474530_ChIP-ChIP_U2OS_Human1.48119321
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.47712588
54* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47179017
55MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.45691746
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44831225
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44272314
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43817571
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43555670
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43108221
61* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.41845539
62ZNF263_19887448_ChIP-Seq_K562_Human1.39744126
63SA1_22415368_ChIP-Seq_MEFs_Mouse1.36952174
64* TBX20_22080862_ChIP-Seq_HEART_Mouse1.36602852
65FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36397676
66TP53_22127205_ChIP-Seq_IMR90_Human1.35969069
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.33247626
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30494215
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30056181
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30056181
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30056181
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29675870
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28286575
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27431977
75* ATF3_27146783_Chip-Seq_COLON_Human1.27414924
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26867099
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26832383
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.26576255
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26158054
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26072896
81SMC1_22415368_ChIP-Seq_MEFs_Mouse1.25592009
82RACK7_27058665_Chip-Seq_MCF-7_Human1.23922426
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23849317
84* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20259079
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20063738
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20057026
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20057026
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19637701
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.18229405
90NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17615109
91* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16360234
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15362859
93KDM2B_26808549_Chip-Seq_DND41_Human1.15356416
94LXR_22292898_ChIP-Seq_THP-1_Human1.14921763
95* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13925460
96* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13650854
97TP53_16413492_ChIP-PET_HCT116_Human1.12576262
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11991732
99PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10100078
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10088615
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10083085
102* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09895871
103SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09696097
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.09611436
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07101828
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06807641
107* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06619790
108KDM2B_26808549_Chip-Seq_K562_Human1.04576911
109* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03803878
110* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03803878
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03609637
112NFI_21473784_ChIP-Seq_ESCs_Mouse1.02987863
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02544304
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01867667
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01782387
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00472622
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99624602
118WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98284066
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98045767
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97181444
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97158593
122KDM2B_26808549_Chip-Seq_JURKAT_Human0.96876527
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96491793
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.95706170
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.95584879
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94934469
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92980951
128* TBX20_22328084_ChIP-Seq_HEART_Mouse0.92306632
129* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91873362
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91400100
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89607673
132ELK1_22589737_ChIP-Seq_MCF10A_Human0.87940181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane4.07849064
2MP0008438_abnormal_cutaneous_collagen3.88682290
3MP0003705_abnormal_hypodermis_morpholog3.53616923
4* MP0005623_abnormal_meninges_morphology3.51246058
5MP0004272_abnormal_basement_membrane3.50963767
6MP0003279_aneurysm3.14834894
7MP0005503_abnormal_tendon_morphology2.93998278
8* MP0010030_abnormal_orbit_morphology2.88016165
9MP0003942_abnormal_urinary_system2.57487930
10MP0009384_cardiac_valve_regurgitation2.54966619
11MP0003123_paternal_imprinting2.45817324
12MP0002249_abnormal_larynx_morphology2.42696973
13MP0003385_abnormal_body_wall2.42687668
14MP0009053_abnormal_anal_canal2.35957829
15MP0009250_abnormal_appendicular_skeleto2.19467606
16MP0000534_abnormal_ureter_morphology2.07783073
17MP0005275_abnormal_skin_tensile2.06324896
18MP0010352_gastrointestinal_tract_polyps2.05505379
19MP0001542_abnormal_bone_strength1.98534119
20MP0000733_abnormal_muscle_development1.95151141
21MP0002877_abnormal_melanocyte_morpholog1.86999475
22MP0003566_abnormal_cell_adhesion1.86097981
23MP0005508_abnormal_skeleton_morphology1.83406931
24MP0002282_abnormal_trachea_morphology1.80214042
25MP0006054_spinal_hemorrhage1.79734577
26* MP0002932_abnormal_joint_morphology1.79453247
27* MP0001879_abnormal_lymphatic_vessel1.77541637
28MP0003091_abnormal_cell_migration1.75314608
29MP0009780_abnormal_chondrocyte_physiolo1.74799704
30MP0000537_abnormal_urethra_morphology1.73706699
31MP0000516_abnormal_urinary_system1.73535562
32MP0005367_renal/urinary_system_phenotyp1.73535562
33MP0001958_emphysema1.73358693
34MP0003122_maternal_imprinting1.64988173
35MP0000767_abnormal_smooth_muscle1.63739528
36MP0003937_abnormal_limbs/digits/tail_de1.61612125
37* MP0000049_abnormal_middle_ear1.60185796
38MP0005595_abnormal_vascular_smooth1.57203571
39* MP0010368_abnormal_lymphatic_system1.56796509
40MP0000678_abnormal_parathyroid_gland1.56413570
41MP0005023_abnormal_wound_healing1.53026410
42MP0003941_abnormal_skin_development1.48497439
43MP0003115_abnormal_respiratory_system1.47558702
44MP0000428_abnormal_craniofacial_morphol1.47475984
45MP0000749_muscle_degeneration1.44784398
46* MP0003935_abnormal_craniofacial_develop1.41333582
47* MP0003755_abnormal_palate_morphology1.36000664
48MP0000013_abnormal_adipose_tissue1.35952766
49MP0004233_abnormal_muscle_weight1.35841782
50* MP0000163_abnormal_cartilage_morphology1.32202639
51MP0003828_pulmonary_edema1.31620927
52* MP0002925_abnormal_cardiovascular_devel1.31095528
53MP0000751_myopathy1.27332611
54MP0004084_abnormal_cardiac_muscle1.25655201
55* MP0001614_abnormal_blood_vessel1.24267595
56MP0002111_abnormal_tail_morphology1.21856867
57MP0002295_abnormal_pulmonary_circulatio1.21063574
58MP0000432_abnormal_head_morphology1.17821750
59MP0003121_genomic_imprinting1.17148533
60MP0005257_abnormal_intraocular_pressure1.16807043
61MP0002233_abnormal_nose_morphology1.16727181
62* MP0002116_abnormal_craniofacial_bone1.14967663
63* MP0002128_abnormal_blood_circulation1.14418917
64* MP0002085_abnormal_embryonic_tissue1.14068397
65MP0003567_abnormal_fetal_cardiomyocyte1.13484238
66MP0001849_ear_inflammation1.11273485
67MP0004197_abnormal_fetal_growth/weight/1.11056959
68MP0002177_abnormal_outer_ear1.08956329
69MP0000759_abnormal_skeletal_muscle1.07996941
70MP0003119_abnormal_digestive_system1.07083209
71MP0002084_abnormal_developmental_patter1.06713085
72MP0002115_abnormal_skeleton_extremities1.06034282
73* MP0001915_intracranial_hemorrhage1.04207430
74MP0002108_abnormal_muscle_morphology1.04142617
75MP0002127_abnormal_cardiovascular_syste1.02274478
76MP0001672_abnormal_embryogenesis/_devel1.00176273
77MP0005380_embryogenesis_phenotype1.00176273
78MP0003984_embryonic_growth_retardation0.99958703
79MP0010630_abnormal_cardiac_muscle0.99748196
80MP0005076_abnormal_cell_differentiation0.99286117
81* MP0002114_abnormal_axial_skeleton0.98740362
82MP0002109_abnormal_limb_morphology0.98646707
83MP0002088_abnormal_embryonic_growth/wei0.98212846
84MP0001697_abnormal_embryo_size0.97527224
85MP0000750_abnormal_muscle_regeneration0.97264255
86MP0004134_abnormal_chest_morphology0.96816084
87* MP0002113_abnormal_skeleton_development0.96381135
88MP0002896_abnormal_bone_mineralization0.96287074
89MP0000003_abnormal_adipose_tissue0.94467543
90MP0008932_abnormal_embryonic_tissue0.93946854
91MP0008007_abnormal_cellular_replicative0.93750170
92MP0005164_abnormal_response_to0.93352101
93MP0004858_abnormal_nervous_system0.93045120
94* MP0000266_abnormal_heart_morphology0.92298439
95MP0001730_embryonic_growth_arrest0.92234552
96MP0001299_abnormal_eye_distance/0.91550237
97MP0006138_congestive_heart_failure0.89829618
98MP0005165_increased_susceptibility_to0.89101491
99MP0002086_abnormal_extraembryonic_tissu0.89060997
100MP0005171_absent_coat_pigmentation0.88625560
101MP0001348_abnormal_lacrimal_gland0.88377141
102MP0002697_abnormal_eye_size0.87479184
103MP0001346_abnormal_lacrimal_gland0.87359984
104MP0000762_abnormal_tongue_morphology0.84029098
105MP0002234_abnormal_pharynx_morphology0.83192257
106* MP0005197_abnormal_uvea_morphology0.82381790
107MP0004808_abnormal_hematopoietic_stem0.82069127
108MP0001243_abnormal_dermal_layer0.81986930
109MP0003448_altered_tumor_morphology0.81400876
110MP0003283_abnormal_digestive_organ0.81183724
111MP0001286_abnormal_eye_development0.80403166
112MP0001175_abnormal_lung_morphology0.80077717
113* MP0002135_abnormal_kidney_morphology0.79783999
114MP0002060_abnormal_skin_morphology0.79196895
115MP0003191_abnormal_cellular_cholesterol0.77696450
116MP0005621_abnormal_cell_physiology0.76815417
117MP0004957_abnormal_blastocyst_morpholog0.76151194
118MP0009278_abnormal_bone_marrow0.76074167
119MP0005390_skeleton_phenotype0.75636661
120MP0002168_other_aberrant_phenotype0.75612806
121MP0000343_altered_response_to0.74328383
122MP0002933_joint_inflammation0.72934091
123MP0004087_abnormal_muscle_fiber0.72287909
124MP0010386_abnormal_urinary_bladder0.72265035
125MP0005409_darkened_coat_color0.71944811
126MP0005360_urolithiasis0.68659556
127MP0005620_abnormal_muscle_contractility0.66451776
128* MP0005193_abnormal_anterior_eye0.65667148
129MP0005330_cardiomyopathy0.64426972
130MP0000467_abnormal_esophagus_morphology0.63340450
131MP0004036_abnormal_muscle_relaxation0.61923506
132MP0000538_abnormal_urinary_bladder0.59498445
133MP0003300_gastrointestinal_ulcer0.58803843
134MP0000249_abnormal_blood_vessel0.57774456
135MP0002972_abnormal_cardiac_muscle0.56897727
136MP0004883_abnormal_blood_vessel0.52989141
137MP0002332_abnormal_exercise_endurance0.52870521

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.34202064
2Premature rupture of membranes (HP:0001788)5.65248669
3Shallow orbits (HP:0000586)4.75368490
4Mesangial abnormality (HP:0001966)4.11305225
5Spondylolisthesis (HP:0003302)3.99338726
6Aortic aneurysm (HP:0004942)3.84133140
7Follicular hyperkeratosis (HP:0007502)3.67024461
8Aortic dissection (HP:0002647)3.60846163
9Focal segmental glomerulosclerosis (HP:0000097)3.40004270
10Broad metatarsal (HP:0001783)3.35436061
11Ankle contracture (HP:0006466)3.33850622
12Soft skin (HP:0000977)3.21709990
13Cerebral aneurysm (HP:0004944)3.06941228
14Coronal craniosynostosis (HP:0004440)3.00266067
15Bladder diverticulum (HP:0000015)2.99204703
16Abnormality of dentin (HP:0010299)2.99151255
17Aortic regurgitation (HP:0001659)2.98070407
18Syringomyelia (HP:0003396)2.88581502
19Spinal cord lesions (HP:0100561)2.88581502
20Slender build (HP:0001533)2.80847301
21Dilatation of the ascending aorta (HP:0005111)2.80547330
22Increased density of long bones (HP:0006392)2.69312204
23Neonatal short-limb short stature (HP:0008921)2.66537402
24Peritonitis (HP:0002586)2.64902802
25Wormian bones (HP:0002645)2.64332595
26Vascular tortuosity (HP:0004948)2.59588554
27Disproportionate tall stature (HP:0001519)2.59474266
28Round ear (HP:0100830)2.58832675
29Ectopia lentis (HP:0001083)2.56363608
30Spinal rigidity (HP:0003306)2.54499726
31Glomerulosclerosis (HP:0000096)2.53860650
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53523036
33Short 4th metacarpal (HP:0010044)2.53523036
34Broad toe (HP:0001837)2.52214098
35Reduced subcutaneous adipose tissue (HP:0003758)2.50572276
36Hypoalbuminemia (HP:0003073)2.49343306
37Abnormal albumin level (HP:0012116)2.49343306
38Biconcave vertebral bodies (HP:0004586)2.47278076
39Wrist flexion contracture (HP:0001239)2.46517042
40Increased variability in muscle fiber diameter (HP:0003557)2.46007736
41Mildly elevated creatine phosphokinase (HP:0008180)2.44775743
42Aortic valve stenosis (HP:0001650)2.41120223
43Short hallux (HP:0010109)2.37548563
44Blue sclerae (HP:0000592)2.35622785
45Increased connective tissue (HP:0009025)2.35293750
46Camptodactyly of toe (HP:0001836)2.31538662
47Bowel diverticulosis (HP:0005222)2.30750381
48Atrophic scars (HP:0001075)2.30184860
49Cardiovascular calcification (HP:0011915)2.30164648
50Mitral valve prolapse (HP:0001634)2.28736898
51Buphthalmos (HP:0000557)2.25091221
52Cervical subluxation (HP:0003308)2.24878647
53Broad hallux (HP:0010055)2.24722420
54Asymmetry of the thorax (HP:0001555)2.23368777
55Joint stiffness (HP:0001387)2.22243430
56* Renal duplication (HP:0000075)2.21516828
57Mitral stenosis (HP:0001718)2.21369994
58Mesomelia (HP:0003027)2.18468522
59Aplasia/Hypoplasia of the hallux (HP:0008362)2.16523665
60Upper limb amyotrophy (HP:0009129)2.16227463
61Distal upper limb amyotrophy (HP:0007149)2.16227463
62Deviation of the hallux (HP:0010051)2.15996901
63Genu recurvatum (HP:0002816)2.14426420
64Vertebral compression fractures (HP:0002953)2.14366827
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.13472457
66Osteolytic defects of the hand bones (HP:0009699)2.13472457
67Nonimmune hydrops fetalis (HP:0001790)2.12758877
68Distal lower limb amyotrophy (HP:0008944)2.12694272
69Abnormality of skeletal muscle fiber size (HP:0012084)2.10978483
70Generalized amyotrophy (HP:0003700)2.10613906
71Back pain (HP:0003418)2.10560845
72Preaxial foot polydactyly (HP:0001841)2.10147337
73Overgrowth (HP:0001548)2.09653528
74Abnormality of the peritoneum (HP:0002585)2.09501907
75Arterial tortuosity (HP:0005116)2.09396655
76Broad long bones (HP:0005622)2.08664307
77Fragile skin (HP:0001030)2.06315073
78Stage 5 chronic kidney disease (HP:0003774)2.05946363
79Abnormality of the 4th metacarpal (HP:0010012)2.04510603
80Broad thumb (HP:0011304)2.04244806
81Hip contracture (HP:0003273)2.04148097
82Aneurysm (HP:0002617)2.03240916
83Hypoventilation (HP:0002791)2.02145185
84Entropion (HP:0000621)2.00545380
85Turricephaly (HP:0000262)1.99891080
86Abnormality of the calcaneus (HP:0008364)1.99465313
87Hallux valgus (HP:0001822)1.98770670
88Mitral regurgitation (HP:0001653)1.92223275
89Knee flexion contracture (HP:0006380)1.91268035
90Fused cervical vertebrae (HP:0002949)1.91115453
91Premature skin wrinkling (HP:0100678)1.90875205
92Distal lower limb muscle weakness (HP:0009053)1.90775780
93Congenital glaucoma (HP:0001087)1.89605210
94Persistence of primary teeth (HP:0006335)1.89323865
95Abnormality of the 2nd finger (HP:0004100)1.89139031
96Broad phalanges of the hand (HP:0009768)1.88313428
97Broad phalanx (HP:0006009)1.86313536
98Flat cornea (HP:0007720)1.86285656
99Hypoplastic left heart (HP:0004383)1.83934770
100Lymphangioma (HP:0100764)1.83644731
101Inguinal hernia (HP:0000023)1.83250974
102Hypoplasia of the iris (HP:0007676)1.82757754
103Difficulty climbing stairs (HP:0003551)1.81939088
104Broad finger (HP:0001500)1.81937397
105Abnormality of the acetabulum (HP:0003170)1.81813992
106Decreased subcutaneous fat (HP:0001002)1.81750971
107Joint contractures involving the joints of the feet (HP:0100492)1.81228629
108Flexion contracture of toe (HP:0005830)1.81228629
109Delayed gross motor development (HP:0002194)1.80981708
110Deviation of the thumb (HP:0009603)1.80632213
111Coxa vara (HP:0002812)1.78960738
112Protruding ear (HP:0000411)1.78449885
113Hyperextensible skin (HP:0000974)1.78280228
114Rectal prolapse (HP:0002035)1.76898615
115Down-sloping shoulders (HP:0200021)1.76726025
116Joint laxity (HP:0001388)1.76485793
117Abnormality of the phalanges of the hallux (HP:0010057)1.76291140
118Wide anterior fontanel (HP:0000260)1.76216303
119Broad ribs (HP:0000885)1.76083815
120Abnormal ossification of hand bones (HP:0005921)1.75848149
121Elbow flexion contracture (HP:0002987)1.75670659
122Achilles tendon contracture (HP:0001771)1.75601154
123Bowed forearm bones (HP:0003956)1.75403070
124Bowing of the arm (HP:0006488)1.75403070
125Abnormality of the fetal cardiovascular system (HP:0010948)1.73846766
126Abnormal umbilical cord blood vessels (HP:0011403)1.73846766
127Single umbilical artery (HP:0001195)1.73846766
128Hepatoblastoma (HP:0002884)1.73367638
129Short nail (HP:0001799)1.72844099
130Scapular winging (HP:0003691)1.72159070
131Arachnodactyly (HP:0001166)1.71810541
132Calcaneovalgus deformity (HP:0001848)1.71561518
133Ulnar bowing (HP:0003031)1.71509080
134Selective tooth agenesis (HP:0001592)1.71371530
135Tubular atrophy (HP:0000092)1.70239536
136Thin bony cortex (HP:0002753)1.70228328
137Infantile muscular hypotonia (HP:0008947)1.70136171
138Natal tooth (HP:0000695)1.69847769
139Abnormality of carpal bone ossification (HP:0006257)1.69829857
140Abnormal delivery (HP:0001787)1.69330910
141Abnormality of the anterior chamber (HP:0000593)1.69109733
142Pterygium (HP:0001059)1.68865621
143Type 1 muscle fiber predominance (HP:0003803)1.68597604
144Long eyelashes (HP:0000527)1.68445979
145Spinal cord compression (HP:0002176)1.68305567
146Lower limb amyotrophy (HP:0007210)1.67648284
147Thin ribs (HP:0000883)1.66188139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.86500669
2EPHB23.52713273
3PDGFRA3.08806537
4LATS13.04752235
5TRIB33.01202913
6TTN2.87844578
7DDR22.57222462
8PAK42.46848402
9PAK22.39887904
10NTRK12.16504275
11TGFBR11.93660427
12BMX1.93476843
13BUB11.86397356
14MYLK1.85513840
15RPS6KA41.73611998
16FLT31.64760404
17PTK21.64482568
18STK38L1.61264928
19KDR1.60425340
20CDC71.57134764
21TIE11.53741552
22ERN11.53614465
23PKN21.52818708
24MST1R1.52495215
25CDK121.51518533
26PTK2B1.51436464
27MKNK11.49993246
28DMPK1.48762359
29FGFR11.45933037
30STK31.43718193
31PRKD21.43452564
32PRKG21.43196939
33NEK21.42639861
34ARAF1.32843549
35WNK41.31245891
36PAK31.29391964
37PTK61.26952506
38LRRK21.26687060
39MAP3K101.26423322
40RIPK11.25852454
41STK241.24799043
42STK381.23947692
43PIM21.21314099
44PRKD31.20209156
45PAK61.20149545
46IRAK31.20057195
47MUSK1.17868184
48LMTK21.16922164
49ILK1.15729569
50MAP3K81.13700000
51LIMK11.11680846
52MTOR1.07705904
53FER1.07532342
54ROCK11.06588858
55TESK11.01276236
56PAK10.92646917
57BRSK20.90552499
58TTK0.90236254
59PDGFRB0.89067974
60TGFBR20.88269873
61EPHA20.87681362
62NEK10.87446067
63CDK80.86326185
64ERBB40.86081331
65ERBB30.85990676
66STK100.81786107
67TESK20.80002291
68MKNK20.79861073
69MAP2K30.78576294
70TRPM70.77275725
71MAPKAPK50.77266634
72TAOK20.76201947
73MET0.75298708
74FRK0.75087153
75PDK20.74485397
76EPHB10.73884687
77MAPKAPK30.72855731
78CDK70.72390430
79AURKB0.72386399
80NUAK10.72365360
81MELK0.70644891
82PLK30.68569416
83MAPK70.67594822
84STK390.67010374
85PLK10.66396035
86SMG10.65410275
87GSK3A0.64859620
88CDK60.63230386
89ABL20.63129149
90WNK10.60973758
91EEF2K0.60443455
92TLK10.59619473
93MAP3K110.59166737
94RPS6KA20.58397392
95MAP2K10.58228789
96AKT30.56410370
97NEK90.54659520
98MOS0.53531462
99WEE10.52906852
100ROCK20.51516782
101CHEK20.51354957
102ALK0.51154304
103CDC42BPA0.51093558
104TAOK10.50866922
105CDK140.50481220
106INSR0.50082410
107BRSK10.48855431
108CDK150.47940835
109MAP3K30.47673716
110CDK40.46420245
111ADRBK10.45640683
112STK160.45220976
113CDK90.43808149
114SIK10.43335833
115CDK180.42931144
116PRKD10.42685525
117ICK0.42593758
118DAPK30.42108970
119CDK11A0.41834749
120CLK10.40344418
121PIK3CG0.39273109
122CHEK10.37971241
123SIK30.37947845
124NME20.36641996
125MAP3K130.36074875
126MAPK10.33976328
127PASK0.33881175
128BRAF0.33390058
129CDK20.33318111
130KSR10.32678638
131CAMK2D0.31477781
132MAP3K70.30067658
133CAMK2G0.26289442
134AURKA0.25825425
135RAF10.25575103
136MAP3K60.25175301

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.66143508
2Focal adhesion_Homo sapiens_hsa045102.97293883
3Adherens junction_Homo sapiens_hsa045202.78239313
4Hippo signaling pathway_Homo sapiens_hsa043902.66383379
5Proteoglycans in cancer_Homo sapiens_hsa052052.61167529
6Basal cell carcinoma_Homo sapiens_hsa052172.55887373
7TGF-beta signaling pathway_Homo sapiens_hsa043502.38290117
8Small cell lung cancer_Homo sapiens_hsa052222.32691624
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.21632586
10MicroRNAs in cancer_Homo sapiens_hsa052062.21123542
11Bladder cancer_Homo sapiens_hsa052192.18146745
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.09514886
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.07745906
14Cell cycle_Homo sapiens_hsa041102.03495510
15Hedgehog signaling pathway_Homo sapiens_hsa043401.95647408
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90667608
17Dilated cardiomyopathy_Homo sapiens_hsa054141.88397862
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.79116502
19Amoebiasis_Homo sapiens_hsa051461.78412358
20Protein digestion and absorption_Homo sapiens_hsa049741.63629757
21Axon guidance_Homo sapiens_hsa043601.59722535
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59302231
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58899662
24Tight junction_Homo sapiens_hsa045301.55522389
25PI3K-Akt signaling pathway_Homo sapiens_hsa041511.54091470
26Wnt signaling pathway_Homo sapiens_hsa043101.53970777
27Chronic myeloid leukemia_Homo sapiens_hsa052201.53129923
28RNA transport_Homo sapiens_hsa030131.50045399
29Regulation of actin cytoskeleton_Homo sapiens_hsa048101.49651216
30p53 signaling pathway_Homo sapiens_hsa041151.48732872
31Pathways in cancer_Homo sapiens_hsa052001.41225113
32Rap1 signaling pathway_Homo sapiens_hsa040151.36873240
33HTLV-I infection_Homo sapiens_hsa051661.31339154
34Spliceosome_Homo sapiens_hsa030401.30706200
35Prostate cancer_Homo sapiens_hsa052151.30364198
36Melanoma_Homo sapiens_hsa052181.26118269
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25605408
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.24173753
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18667399
40Shigellosis_Homo sapiens_hsa051311.18459440
41Notch signaling pathway_Homo sapiens_hsa043301.13455812
42Viral myocarditis_Homo sapiens_hsa054161.11446142
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10752097
44Colorectal cancer_Homo sapiens_hsa052101.10019955
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09589748
46Melanogenesis_Homo sapiens_hsa049161.08254830
47Renal cell carcinoma_Homo sapiens_hsa052111.07527441
48Pancreatic cancer_Homo sapiens_hsa052121.02743077
49Prion diseases_Homo sapiens_hsa050201.00170568
50HIF-1 signaling pathway_Homo sapiens_hsa040660.97275186
51Oocyte meiosis_Homo sapiens_hsa041140.95575728
52Sulfur relay system_Homo sapiens_hsa041220.95469825
53Systemic lupus erythematosus_Homo sapiens_hsa053220.95263597
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94728397
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94164806
56Vibrio cholerae infection_Homo sapiens_hsa051100.92146638
57Thyroid cancer_Homo sapiens_hsa052160.91995234
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90871698
59Glioma_Homo sapiens_hsa052140.90165677
60Gap junction_Homo sapiens_hsa045400.89361746
61Platelet activation_Homo sapiens_hsa046110.89134816
62Viral carcinogenesis_Homo sapiens_hsa052030.88997358
63mRNA surveillance pathway_Homo sapiens_hsa030150.88214832
64One carbon pool by folate_Homo sapiens_hsa006700.87963652
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87340303
66Renin-angiotensin system_Homo sapiens_hsa046140.84910092
67Ribosome_Homo sapiens_hsa030100.84779633
68Endometrial cancer_Homo sapiens_hsa052130.78996392
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76988609
70Sulfur metabolism_Homo sapiens_hsa009200.76314711
71mTOR signaling pathway_Homo sapiens_hsa041500.76233248
72Estrogen signaling pathway_Homo sapiens_hsa049150.74294963
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.74082898
74Malaria_Homo sapiens_hsa051440.72330069
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70558105
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69191539
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.66708728
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65711287
79Lysine degradation_Homo sapiens_hsa003100.65483002
80Ras signaling pathway_Homo sapiens_hsa040140.61948488
81Galactose metabolism_Homo sapiens_hsa000520.60982956
82VEGF signaling pathway_Homo sapiens_hsa043700.60204648
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56949625
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56724782
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.56606433
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54747250
87Hepatitis B_Homo sapiens_hsa051610.54308115
88FoxO signaling pathway_Homo sapiens_hsa040680.52979495
89Alcoholism_Homo sapiens_hsa050340.52963267
90Apoptosis_Homo sapiens_hsa042100.52824160
91TNF signaling pathway_Homo sapiens_hsa046680.52600297
92Pentose phosphate pathway_Homo sapiens_hsa000300.52187287
93Complement and coagulation cascades_Homo sapiens_hsa046100.50202845
94Salmonella infection_Homo sapiens_hsa051320.50016399
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49893486
96DNA replication_Homo sapiens_hsa030300.49234514
97MAPK signaling pathway_Homo sapiens_hsa040100.45834390
98N-Glycan biosynthesis_Homo sapiens_hsa005100.44079373
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43662481
100Thyroid hormone synthesis_Homo sapiens_hsa049180.42348743
101Toxoplasmosis_Homo sapiens_hsa051450.41099847
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.41077987
103Epstein-Barr virus infection_Homo sapiens_hsa051690.40939725
104Endocytosis_Homo sapiens_hsa041440.40266454
105Folate biosynthesis_Homo sapiens_hsa007900.39659238
106Non-small cell lung cancer_Homo sapiens_hsa052230.39337172
107ErbB signaling pathway_Homo sapiens_hsa040120.36933090
108Cocaine addiction_Homo sapiens_hsa050300.36307086
109AMPK signaling pathway_Homo sapiens_hsa041520.35506100
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35435985
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34418486
112Pertussis_Homo sapiens_hsa051330.34238678
113Mineral absorption_Homo sapiens_hsa049780.33778240
114Dorso-ventral axis formation_Homo sapiens_hsa043200.32529626
115Glutathione metabolism_Homo sapiens_hsa004800.32186152
116GnRH signaling pathway_Homo sapiens_hsa049120.32085708
117Glucagon signaling pathway_Homo sapiens_hsa049220.31904122
118Biosynthesis of amino acids_Homo sapiens_hsa012300.31173486
119Nucleotide excision repair_Homo sapiens_hsa034200.30467353
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30449914
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30306636
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.29688225
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29155916

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