FOXD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)9.88592517
2glomerular epithelial cell development (GO:0072310)8.57892388
3glomerular basement membrane development (GO:0032836)8.11630549
4ribosomal small subunit assembly (GO:0000028)7.72184785
5viral transcription (GO:0019083)6.63780657
6translational termination (GO:0006415)6.31820521
7glomerulus development (GO:0032835)5.86335315
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.56724871
9translational elongation (GO:0006414)5.54169528
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.00677481
11definitive hemopoiesis (GO:0060216)4.99417445
12protein targeting to ER (GO:0045047)4.90486421
13positive regulation of gamma-delta T cell activation (GO:0046645)4.89430791
14viral life cycle (GO:0019058)4.87837530
15cotranslational protein targeting to membrane (GO:0006613)4.86350632
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.83206184
17pharyngeal system development (GO:0060037)4.78949068
18regulation of gamma-delta T cell differentiation (GO:0045586)4.74972222
19cellular protein complex disassembly (GO:0043624)4.74846781
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.68292382
21ribosomal small subunit biogenesis (GO:0042274)4.62112432
22cellular response to ATP (GO:0071318)4.57324215
23protein localization to endoplasmic reticulum (GO:0070972)4.47829159
24protein complex biogenesis (GO:0070271)4.46334550
25water-soluble vitamin biosynthetic process (GO:0042364)4.45499344
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.41350358
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.41350358
28NADH dehydrogenase complex assembly (GO:0010257)4.41350358
29kidney mesenchyme development (GO:0072074)4.40368208
30negative regulation of erythrocyte differentiation (GO:0045647)4.32122801
31protein complex disassembly (GO:0043241)4.30040371
32regulation of apoptotic process involved in morphogenesis (GO:1902337)4.20676214
33positive regulation of fatty acid oxidation (GO:0046321)4.12417429
34metanephric mesenchyme development (GO:0072075)4.10826090
35mitochondrial respiratory chain complex assembly (GO:0033108)4.09263500
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06815658
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06815658
38DNA replication checkpoint (GO:0000076)4.05743915
39translational initiation (GO:0006413)4.04833896
40somite development (GO:0061053)4.03744658
41regulation of gamma-delta T cell activation (GO:0046643)4.02291042
42base-excision repair, AP site formation (GO:0006285)3.98512078
43positive regulation of histone deacetylation (GO:0031065)3.96474754
44maturation of SSU-rRNA (GO:0030490)3.95897437
45cell proliferation in forebrain (GO:0021846)3.95330457
46macromolecular complex disassembly (GO:0032984)3.94809553
47piRNA metabolic process (GO:0034587)3.90416900
48epithelial cell differentiation involved in kidney development (GO:0035850)3.85381599
49spindle assembly involved in mitosis (GO:0090307)3.80777811
50regulation of cell proliferation involved in kidney development (GO:1901722)3.70872358
51RNA localization (GO:0006403)3.68575643
52Peyers patch development (GO:0048541)3.67804675
53mucosal-associated lymphoid tissue development (GO:0048537)3.67804675
54positive regulation of blood vessel endothelial cell migration (GO:0043536)3.66774095
55DNA deamination (GO:0045006)3.65122595
56pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.64239363
57negative regulation of acute inflammatory response (GO:0002674)3.63299319
58response to lipoprotein particle (GO:0055094)3.63131599
59ribosomal large subunit biogenesis (GO:0042273)3.60985637
60DNA methylation involved in gamete generation (GO:0043046)3.60922610
61mitochondrion morphogenesis (GO:0070584)3.60766435
62negative regulation of telomerase activity (GO:0051974)3.53159149
63lung morphogenesis (GO:0060425)3.51745633
64coronary vasculature morphogenesis (GO:0060977)3.49429771
65regulation of glomerulus development (GO:0090192)3.45995138
66regulation of regulatory T cell differentiation (GO:0045589)3.43667692
67mannosylation (GO:0097502)3.41075418
68nuclear-transcribed mRNA catabolic process (GO:0000956)3.38928371
69endothelial cell chemotaxis (GO:0035767)3.37375867
70protein targeting to membrane (GO:0006612)3.37152942
71antigen processing and presentation of endogenous antigen (GO:0019883)3.34468135
72protein K6-linked ubiquitination (GO:0085020)3.32225693
73branching involved in labyrinthine layer morphogenesis (GO:0060670)3.31179751
74synapsis (GO:0007129)3.29992568
75megakaryocyte development (GO:0035855)3.29690437
76preassembly of GPI anchor in ER membrane (GO:0016254)3.29017922
77regulation of telomerase activity (GO:0051972)3.27885289
78negative regulation of T cell differentiation in thymus (GO:0033085)3.27260029
79mRNA catabolic process (GO:0006402)3.26725856
80regulation of receptor binding (GO:1900120)3.25487002
81white fat cell differentiation (GO:0050872)3.23774131
82DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.22138367
83pyrimidine nucleotide catabolic process (GO:0006244)3.19842266
84cellular response to lithium ion (GO:0071285)3.19723263
85ncRNA 3-end processing (GO:0043628)3.17554751
86germ cell migration (GO:0008354)3.17424731
87maturation of 5.8S rRNA (GO:0000460)3.14756101
88rRNA catabolic process (GO:0016075)3.14047684
89cytochrome complex assembly (GO:0017004)3.12483787
90meiotic chromosome segregation (GO:0045132)3.12244343
91behavioral response to nicotine (GO:0035095)3.11787670
92pseudouridine synthesis (GO:0001522)3.11679300
93mature B cell differentiation involved in immune response (GO:0002313)3.07147949
94pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.06305538
95positive regulation of protein deacetylation (GO:0090312)3.05670611
96RNA catabolic process (GO:0006401)3.01224505
973-UTR-mediated mRNA stabilization (GO:0070935)3.01099320
98venous blood vessel morphogenesis (GO:0048845)2.99515848
99lymph node development (GO:0048535)2.98978033
100cell proliferation involved in metanephros development (GO:0072203)2.98784597
101positive regulation of cell adhesion mediated by integrin (GO:0033630)2.95668554
102lipopolysaccharide biosynthetic process (GO:0009103)2.94890088
103positive regulation of oligodendrocyte differentiation (GO:0048714)2.93485262
104negative regulation of metanephros development (GO:0072217)2.92445707
105CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.90522352
106regulation of mitochondrial translation (GO:0070129)2.89146783
107mesenchymal to epithelial transition (GO:0060231)2.88851127
108neuron fate specification (GO:0048665)2.88650436
109flavonoid metabolic process (GO:0009812)2.86057351
110establishment of protein localization to mitochondrial membrane (GO:0090151)2.83746901
111thyroid gland development (GO:0030878)2.83471814
112positive regulation of cAMP-mediated signaling (GO:0043950)2.83037300
113renal filtration (GO:0097205)2.82465028
114positive regulation of glomerulus development (GO:0090193)2.81741898
115chromosome organization involved in meiosis (GO:0070192)2.80923300
116prostate gland growth (GO:0060736)2.80374686
117mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.78689090
118diaphragm development (GO:0060539)2.77990286
119sodium-independent organic anion transport (GO:0043252)2.77258320
120negative regulation of RNA splicing (GO:0033119)2.76870013
121DNA damage response, signal transduction resulting in transcription (GO:0042772)2.75306085
122mesodermal cell differentiation (GO:0048333)2.74841061
123DNA unwinding involved in DNA replication (GO:0006268)2.74617530
124positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.74482366
125T cell homeostasis (GO:0043029)2.73228112
126replication fork processing (GO:0031297)2.72761219
127cell differentiation involved in embryonic placenta development (GO:0060706)2.72593995
128respiratory chain complex IV assembly (GO:0008535)2.72383129
129mesonephros development (GO:0001823)2.71949445
130positive regulation of potassium ion transmembrane transport (GO:1901381)2.71220675
131membrane repolarization during action potential (GO:0086011)2.70797536
132middle ear morphogenesis (GO:0042474)2.70422700
133ureteric bud development (GO:0001657)2.70354421
134membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.67248115
135GPI anchor metabolic process (GO:0006505)2.66547730
136microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.66093942
137lymph vessel development (GO:0001945)2.65464159
138male meiosis I (GO:0007141)2.65275546
139natural killer cell differentiation (GO:0001779)2.65258958
140glandular epithelial cell differentiation (GO:0002067)2.64049048
141cell adhesion mediated by integrin (GO:0033627)2.63195198
142mesonephric tubule development (GO:0072164)2.62555761
143respiratory tube development (GO:0030323)2.62222200
144regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61536515
1453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.61236601
146purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.61236601
147nucleotide transmembrane transport (GO:1901679)2.60503064
148glucocorticoid receptor signaling pathway (GO:0042921)2.59068857
149rRNA metabolic process (GO:0016072)2.59026524
150T-helper 1 type immune response (GO:0042088)2.58283632
151positive regulation of triglyceride biosynthetic process (GO:0010867)2.57838006
152negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57673026
153negative regulation of phagocytosis (GO:0050765)2.57136555
154outer ear morphogenesis (GO:0042473)2.57086712
155double-strand break repair via homologous recombination (GO:0000724)2.56985996
156skeletal muscle organ development (GO:0060538)2.56613751
157positive regulation of prostaglandin secretion (GO:0032308)2.56098950
158mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55219300
159mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55219300
160tRNA processing (GO:0008033)2.54630647
161mesonephric epithelium development (GO:0072163)2.54214263
162rRNA processing (GO:0006364)2.54199705
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54133722
164DNA topological change (GO:0006265)2.53788165
165regulation of stem cell maintenance (GO:2000036)2.53557340
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52720441
167recombinational repair (GO:0000725)2.52658360
168mature B cell differentiation (GO:0002335)2.52499516
169metanephros development (GO:0001656)2.52157411
170cell migration involved in heart development (GO:0060973)2.51591387
171negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.51381030
172pituitary gland development (GO:0021983)2.51211263
173pericardium development (GO:0060039)2.50653104
174mRNA stabilization (GO:0048255)2.50404500
175RNA stabilization (GO:0043489)2.50404500
176T cell lineage commitment (GO:0002360)2.49845354
177renal system development (GO:0072001)2.49244108
178regulation of female receptivity (GO:0045924)2.48742265
179nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48362552
180myeloid dendritic cell activation (GO:0001773)2.48098460
181positive regulation of natural killer cell differentiation (GO:0032825)2.47078155
182glycine metabolic process (GO:0006544)2.46384959
183dentate gyrus development (GO:0021542)2.46336505
184positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.45934626
185erythrocyte maturation (GO:0043249)2.45881597
186necroptotic process (GO:0070266)2.45877744
187sulfation (GO:0051923)2.45567988
188ubiquinone biosynthetic process (GO:0006744)2.45487071
189O-glycan processing (GO:0016266)2.45148443
190embryonic skeletal joint morphogenesis (GO:0060272)2.44941859
191positive regulation of metanephros development (GO:0072216)2.44621848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human4.98922664
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.30901483
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.06870796
4MYC_22102868_ChIP-Seq_BL_Human3.50942027
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.32156234
6SCL_19346495_ChIP-Seq_HPC-7_Human3.23239449
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.17759224
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.14819901
9E2F7_22180533_ChIP-Seq_HELA_Human3.07298897
10VDR_21846776_ChIP-Seq_THP-1_Human3.06370015
11TCF7_22412390_ChIP-Seq_EML_Mouse2.95022569
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.85983088
13* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.71314999
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67992109
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.57851045
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.56637518
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.52701883
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45501997
19* TP63_19390658_ChIP-ChIP_HaCaT_Human2.42704716
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42118643
21* MYC_18940864_ChIP-ChIP_HL60_Human2.37830238
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.37092857
23CDX2_20551321_ChIP-Seq_CACO-2_Human2.34616503
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.32082894
25WT1_19549856_ChIP-ChIP_CCG9911_Human2.32010974
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.29875253
27VDR_24763502_ChIP-Seq_THP-1_Human2.26020889
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25944127
29* KDM2B_26808549_Chip-Seq_DND41_Human2.22559619
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20800719
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19888718
32* ELK3_25401928_ChIP-Seq_HUVEC_Human2.19269034
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12245673
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.11692400
35TDRD3_21172665_ChIP-Seq_MCF-7_Human2.11479474
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09476578
37* UTX_26944678_Chip-Seq_JUKART_Human2.04265183
38* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04017616
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00322502
40* EZH2_27304074_Chip-Seq_ESCs_Mouse1.98708386
41* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97983822
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97030131
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91962639
44* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89826581
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85322125
46* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85046276
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.84738168
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80723152
49* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78328157
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.77617677
51ZNF274_21170338_ChIP-Seq_K562_Hela1.75302589
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.73155510
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72054049
54* MAF_26560356_Chip-Seq_TH1_Human1.71547888
55KDM5A_27292631_Chip-Seq_BREAST_Human1.69017397
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.68765827
57NCOR1_26117541_ChIP-Seq_K562_Human1.68321474
58EZH2_22144423_ChIP-Seq_EOC_Human1.65718588
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62853940
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62234007
61* TP53_20018659_ChIP-ChIP_R1E_Mouse1.62034925
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59615262
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59523120
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57460117
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56793652
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.55348690
67* RNF2_27304074_Chip-Seq_NSC_Mouse1.55225582
68FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53121198
69TTF2_22483619_ChIP-Seq_HELA_Human1.51269271
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50881783
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50862202
72LXR_22292898_ChIP-Seq_THP-1_Human1.50068406
73* SPI1_23547873_ChIP-Seq_NB4_Human1.49768176
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48928940
75* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48053393
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44621275
77IRF1_19129219_ChIP-ChIP_H3396_Human1.43440032
78* KDM2B_26808549_Chip-Seq_JURKAT_Human1.43208054
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42812678
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42062236
81VDR_22108803_ChIP-Seq_LS180_Human1.41880607
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40336046
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.38832180
84CIITA_25753668_ChIP-Seq_RAJI_Human1.38241337
85FOXP3_21729870_ChIP-Seq_TREG_Human1.38041483
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37043626
87GABP_19822575_ChIP-Seq_HepG2_Human1.36709431
88RUNX_20019798_ChIP-Seq_JUKART_Human1.36108261
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36032052
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35614826
91TRIM28_21343339_ChIP-Seq_HEK293_Human1.34834753
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.33948642
93E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32363664
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31982030
95RACK7_27058665_Chip-Seq_MCF-7_Human1.30916927
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30777500
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29833493
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.29333755
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28291756
100* KDM2B_26808549_Chip-Seq_K562_Human1.27292899
101XRN2_22483619_ChIP-Seq_HELA_Human1.26079272
102BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25984206
103E2F1_20622854_ChIP-Seq_HELA_Human1.25425021
104* EZH2_27294783_Chip-Seq_ESCs_Mouse1.25411368
105RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24987666
106ERA_21632823_ChIP-Seq_H3396_Human1.24578705
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24507350
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24426862
109GATA1_26923725_Chip-Seq_HPCs_Mouse1.23293260
110SRF_21415370_ChIP-Seq_HL-1_Mouse1.23265558
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23186211
112* MAF_26560356_Chip-Seq_TH2_Human1.22656267
113* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22474591
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21599166
115P68_20966046_ChIP-Seq_HELA_Human1.20978391
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20539542
117* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20217801
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17861183
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16966023
120MYB_26560356_Chip-Seq_TH2_Human1.16639417
121P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16620556
122* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16604426
123* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16604426
124TAF2_19829295_ChIP-Seq_ESCs_Human1.16339938
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16043651
126ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15740858
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15739950
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14936648
129VDR_23849224_ChIP-Seq_CD4+_Human1.14767113
130* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14727103
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13979205
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13197980
133EWS_26573619_Chip-Seq_HEK293_Human1.11661077
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11222217
135AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10822135
136GATA2_21666600_ChIP-Seq_HMVEC_Human1.10805624
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10573966
138STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10081124
139CTCF_20526341_ChIP-Seq_ESCs_Human1.09692818
140* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.09357520
141STAT1_20625510_ChIP-Seq_HELA_Human1.08173385
142GATA6_25053715_ChIP-Seq_YYC3_Human1.08152467
143CLOCK_20551151_ChIP-Seq_293T_Human1.06999955
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06485561
145DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04941638
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04418934
147YY1_22570637_ChIP-Seq_MALME-3M_Human1.03043108
148BCL6_27268052_Chip-Seq_Bcells_Human1.02675353
149* ESR1_21235772_ChIP-Seq_MCF-7_Human1.02436595
150* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02413827
151SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01952265
152ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01552724
153KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01515252
154FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00848708
155MYB_26560356_Chip-Seq_TH1_Human1.00529863
156MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99596037
157CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99476219
158* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97806906
159GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97677631
160HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97428143
161SPI1_23127762_ChIP-Seq_K562_Human0.97135750
162FOXP1_21924763_ChIP-Seq_HESCs_Human0.97113949
163PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97041236
164E2F1_21310950_ChIP-Seq_MCF-7_Human0.97007889
165ATF3_27146783_Chip-Seq_COLON_Human0.96240983
166RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96104285
167GATA3_21878914_ChIP-Seq_MCF-7_Human0.95979816
168* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95201303
169NCOR_22424771_ChIP-Seq_293T_Human0.93887876
170EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93792618
171LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93544950
172ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93317858
173SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92221119
174SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92221119
175SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91873571
176MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91223569
177TP53_22573176_ChIP-Seq_HFKS_Human0.89777430
178NANOG_20526341_ChIP-Seq_ESCs_Human0.89727091
179* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88029666
180RAC3_21632823_ChIP-Seq_H3396_Human0.87907621
181CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86664996
182* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86414769
183* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86262112
184PHF8_20622854_ChIP-Seq_HELA_Human0.83797543
185SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.82905639
186ER_23166858_ChIP-Seq_MCF-7_Human0.82453704
187ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82047263
188* PHF8_20622853_ChIP-Seq_HELA_Human0.79910904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.00538128
2MP0005623_abnormal_meninges_morphology3.68626181
3MP0005646_abnormal_pituitary_gland3.53888527
4MP0003866_abnormal_defecation3.52219133
5MP0005670_abnormal_white_adipose3.20941049
6MP0010368_abnormal_lymphatic_system3.17775191
7MP0004808_abnormal_hematopoietic_stem2.94358345
8MP0002160_abnormal_reproductive_system2.90014339
9MP0006292_abnormal_olfactory_placode2.89885301
10MP0002163_abnormal_gland_morphology2.79615211
11MP0000490_abnormal_crypts_of2.63696237
12MP0000465_gastrointestinal_hemorrhage2.61578693
13MP0001879_abnormal_lymphatic_vessel2.55533135
14MP0003300_gastrointestinal_ulcer2.43274155
15MP0010155_abnormal_intestine_physiology2.41834772
16MP0001661_extended_life_span2.39822174
17MP0003942_abnormal_urinary_system2.36963665
18MP0005389_reproductive_system_phenotype2.29034167
19MP0006054_spinal_hemorrhage2.28463960
20MP0010030_abnormal_orbit_morphology2.27747725
21MP0003646_muscle_fatigue2.24962335
22MP0005397_hematopoietic_system_phenotyp2.22905334
23MP0001545_abnormal_hematopoietic_system2.22905334
24MP0004185_abnormal_adipocyte_glucose2.13215243
25MP0002234_abnormal_pharynx_morphology2.12727648
26MP0002876_abnormal_thyroid_physiology2.12120663
27MP0009053_abnormal_anal_canal2.11036466
28MP0000013_abnormal_adipose_tissue2.10821395
29MP0003283_abnormal_digestive_organ2.04773349
30MP0000631_abnormal_neuroendocrine_gland1.99786918
31MP0010352_gastrointestinal_tract_polyps1.96849034
32MP0002396_abnormal_hematopoietic_system1.96130429
33MP0003315_abnormal_perineum_morphology1.93466816
34MP0000516_abnormal_urinary_system1.93444581
35MP0005367_renal/urinary_system_phenotyp1.93444581
36MP0001873_stomach_inflammation1.92338200
37MP0001485_abnormal_pinna_reflex1.87426569
38MP0003279_aneurysm1.86146589
39MP0003943_abnormal_hepatobiliary_system1.85469731
40MP0002837_dystrophic_cardiac_calcinosis1.85047413
41MP0000477_abnormal_intestine_morphology1.82340455
42MP0004130_abnormal_muscle_cell1.74286731
43MP0008877_abnormal_DNA_methylation1.70154294
44MP0001919_abnormal_reproductive_system1.67551183
45MP0005379_endocrine/exocrine_gland_phen1.64114824
46MP0003119_abnormal_digestive_system1.60368989
47MP0000685_abnormal_immune_system1.57559668
48MP0002138_abnormal_hepatobiliary_system1.57307598
49* MP0000534_abnormal_ureter_morphology1.56887135
50MP0000681_abnormal_thyroid_gland1.54304484
51MP0001663_abnormal_digestive_system1.53098614
52MP0002249_abnormal_larynx_morphology1.51880494
53MP0008872_abnormal_physiological_respon1.51568137
54MP0002102_abnormal_ear_morphology1.50508742
55MP0009333_abnormal_splenocyte_physiolog1.47617901
56MP0001849_ear_inflammation1.42867014
57MP0001986_abnormal_taste_sensitivity1.42426394
58MP0003303_peritoneal_inflammation1.39757517
59MP0002932_abnormal_joint_morphology1.39621075
60MP0004272_abnormal_basement_membrane1.38218010
61MP0000858_altered_metastatic_potential1.37666744
62MP0004885_abnormal_endolymph1.36474893
63MP0003937_abnormal_limbs/digits/tail_de1.33376056
64MP0004043_abnormal_pH_regulation1.33087129
65MP0002398_abnormal_bone_marrow1.32913768
66MP0005671_abnormal_response_to1.31337948
67MP0005174_abnormal_tail_pigmentation1.31190226
68MP0009379_abnormal_foot_pigmentation1.29741003
69* MP0002135_abnormal_kidney_morphology1.27980745
70MP0000703_abnormal_thymus_morphology1.27239073
71MP0003763_abnormal_thymus_physiology1.27060871
72MP0000003_abnormal_adipose_tissue1.26681655
73MP0001944_abnormal_pancreas_morphology1.23631384
74MP0005381_digestive/alimentary_phenotyp1.23563931
75MP0002722_abnormal_immune_system1.22697793
76MP0000372_irregular_coat_pigmentation1.22184774
77MP0002277_abnormal_respiratory_mucosa1.21982164
78MP0003705_abnormal_hypodermis_morpholog1.20689571
79MP0009250_abnormal_appendicular_skeleto1.20641358
80MP0000733_abnormal_muscle_development1.20353254
81MP0003123_paternal_imprinting1.20058269
82MP0002139_abnormal_hepatobiliary_system1.19745436
83MP0003936_abnormal_reproductive_system1.18975807
84MP0005023_abnormal_wound_healing1.17526090
85MP0004381_abnormal_hair_follicle1.16262918
86MP0001727_abnormal_embryo_implantation1.15785430
87MP0005464_abnormal_platelet_physiology1.15750925
88MP0001800_abnormal_humoral_immune1.15506608
89MP0010094_abnormal_chromosome_stability1.13710963
90MP0002128_abnormal_blood_circulation1.11861894
91MP0003385_abnormal_body_wall1.11551628
92MP0001915_intracranial_hemorrhage1.11486616
93MP0002452_abnormal_antigen_presenting1.11402763
94MP0001819_abnormal_immune_cell1.10664068
95MP0002420_abnormal_adaptive_immunity1.10315590
96MP0003115_abnormal_respiratory_system1.10214388
97MP0001765_abnormal_ion_homeostasis1.09393568
98MP0004145_abnormal_muscle_electrophysio1.08808401
99MP0002166_altered_tumor_susceptibility1.07973423
100MP0008961_abnormal_basal_metabolism1.06975284
101MP0008058_abnormal_DNA_repair1.06386700
102MP0000689_abnormal_spleen_morphology1.04692986
103MP0008875_abnormal_xenobiotic_pharmacok1.03769045
104MP0000678_abnormal_parathyroid_gland1.03390770
105MP0000716_abnormal_immune_system1.02307591
106MP0002429_abnormal_blood_cell1.02018442
107MP0005167_abnormal_blood-brain_barrier1.01893641
108MP0005220_abnormal_exocrine_pancreas1.01755007
109MP0004264_abnormal_extraembryonic_tissu1.01601264
110MP0005166_decreased_susceptibility_to1.00347605
111MP0000767_abnormal_smooth_muscle0.99814208
112MP0002136_abnormal_kidney_physiology0.99531086
113MP0000470_abnormal_stomach_morphology0.99317647
114MP0002210_abnormal_sex_determination0.98454326
115MP0002089_abnormal_postnatal_growth/wei0.98322976
116MP0000015_abnormal_ear_pigmentation0.97833763
117MP0003567_abnormal_fetal_cardiomyocyte0.97092128
118MP0002938_white_spotting0.96349813
119MP0006036_abnormal_mitochondrial_physio0.96232428
120MP0002723_abnormal_immune_serum0.95445337
121MP0002282_abnormal_trachea_morphology0.94899506
122MP0003693_abnormal_embryo_hatching0.94653939
123MP0005503_abnormal_tendon_morphology0.94050312
124MP0003935_abnormal_craniofacial_develop0.93566381
125MP0002925_abnormal_cardiovascular_devel0.93247024
126MP0004134_abnormal_chest_morphology0.93049314
127MP0001614_abnormal_blood_vessel0.93013058
128MP0003786_premature_aging0.91322171
129MP0003091_abnormal_cell_migration0.91246098
130MP0010307_abnormal_tumor_latency0.90962337
131MP0001845_abnormal_inflammatory_respons0.90389792
132MP0001664_abnormal_digestion0.90156499
133MP0003436_decreased_susceptibility_to0.89233722
134MP0006035_abnormal_mitochondrial_morpho0.88473037
135MP0005636_abnormal_mineral_homeostasis0.88372480
136MP0002113_abnormal_skeleton_development0.87954929
137MP0003879_abnormal_hair_cell0.87940515
138MP0001145_abnormal_male_reproductive0.87324742
139MP0003566_abnormal_cell_adhesion0.85051914
140MP0005645_abnormal_hypothalamus_physiol0.84385321
141MP0008770_decreased_survivor_rate0.83577049
142MP0001784_abnormal_fluid_regulation0.83144362
143MP0000653_abnormal_sex_gland0.81747128
144MP0002086_abnormal_extraembryonic_tissu0.80882127
145MP0004197_abnormal_fetal_growth/weight/0.80370720
146MP0002877_abnormal_melanocyte_morpholog0.80281569
147MP0009765_abnormal_xenobiotic_induced0.80263238
148MP0005508_abnormal_skeleton_morphology0.79802504
149MP0005025_abnormal_response_to0.78214205
150MP0009780_abnormal_chondrocyte_physiolo0.77686624
151MP0001502_abnormal_circadian_rhythm0.77170767
152MP0005083_abnormal_biliary_tract0.76897544
153MP0003077_abnormal_cell_cycle0.76856541
154MP0000049_abnormal_middle_ear0.76497371
155MP0003638_abnormal_response/metabolism_0.76463838
156MP0000537_abnormal_urethra_morphology0.76251497
157MP0002998_abnormal_bone_remodeling0.75956996
158MP0001764_abnormal_homeostasis0.74752434
159MP0008995_early_reproductive_senescence0.74264538
160MP0005387_immune_system_phenotype0.74060581
161MP0001790_abnormal_immune_system0.74060581
162MP0003938_abnormal_ear_development0.73610360
163MP0002693_abnormal_pancreas_physiology0.73545684
164MP0000427_abnormal_hair_cycle0.73508961
165MP0000163_abnormal_cartilage_morphology0.71829970
166MP0002116_abnormal_craniofacial_bone0.71677592
167MP0000613_abnormal_salivary_gland0.71637506
168MP0005195_abnormal_posterior_eye0.71392651
169MP0000383_abnormal_hair_follicle0.71295584
170MP0002933_joint_inflammation0.70486883
171MP0002095_abnormal_skin_pigmentation0.70061042
172MP0001697_abnormal_embryo_size0.69902839
173MP0004947_skin_inflammation0.69747378
174MP0000026_abnormal_inner_ear0.69263211
175MP0005551_abnormal_eye_electrophysiolog0.68244093
176MP0000467_abnormal_esophagus_morphology0.68172538
177MP0004957_abnormal_blastocyst_morpholog0.67644666
178MP0002177_abnormal_outer_ear0.66404669
179MP0003111_abnormal_nucleus_morphology0.65481753
180MP0005408_hypopigmentation0.65372732
181MP0004142_abnormal_muscle_tone0.65270833

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)6.98955557
2Focal segmental glomerulosclerosis (HP:0000097)5.60931249
3Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.49156045
4Short 1st metacarpal (HP:0010034)5.49156045
5Abnormality of the 1st metacarpal (HP:0010009)5.05329749
6Hypoalbuminemia (HP:0003073)4.77826628
7Abnormal albumin level (HP:0012116)4.77826628
8Aortic aneurysm (HP:0004942)4.34177551
9Glomerulosclerosis (HP:0000096)4.18322171
10Hyperthyroidism (HP:0000836)3.93676243
11Thrombocytosis (HP:0001894)3.91200159
12Acute necrotizing encephalopathy (HP:0006965)3.76128045
13Abnormality of cells of the erythroid lineage (HP:0012130)3.56099446
14Pendular nystagmus (HP:0012043)3.52632694
15Abnormality of the renal collecting system (HP:0004742)3.50586752
16Nonprogressive disorder (HP:0003680)3.50525715
17Abnormal mitochondria in muscle tissue (HP:0008316)3.49362469
18Absent thumb (HP:0009777)3.45568226
19Ectopic kidney (HP:0000086)3.41058489
20Stenosis of the external auditory canal (HP:0000402)3.24548664
21Acute encephalopathy (HP:0006846)3.22368639
22Aplastic anemia (HP:0001915)3.19331992
23Petechiae (HP:0000967)3.18377471
24Progressive macrocephaly (HP:0004481)3.15419134
25Protrusio acetabuli (HP:0003179)3.11343842
26Abnormality of the proximal phalanges of the hand (HP:0009834)3.11292830
27Renal duplication (HP:0000075)3.11110026
28Abnormality of DNA repair (HP:0003254)3.04573027
29Spontaneous hematomas (HP:0007420)3.03439559
30Tubular atrophy (HP:0000092)3.01717526
31Abnormality of the nasal mucosa (HP:0000433)3.00737546
32Reticulocytopenia (HP:0001896)2.99847258
33Stage 5 chronic kidney disease (HP:0003774)2.98490641
34Abnormality of the nasal septum (HP:0000419)2.98122527
35Hematochezia (HP:0002573)2.95603617
36Short hallux (HP:0010109)2.94769552
37Hypoplasia of the uterus (HP:0000013)2.88861608
38Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.84746102
39Colon cancer (HP:0003003)2.84373618
40Duplicated collecting system (HP:0000081)2.82219352
41Abnormality of the fingertips (HP:0001211)2.78227957
42Congenital sensorineural hearing impairment (HP:0008527)2.76755660
43Synostosis of carpal bones (HP:0005048)2.73760464
44Aortic dissection (HP:0002647)2.72352177
45Concave nail (HP:0001598)2.64253995
46Nephritis (HP:0000123)2.62836597
47Severe muscular hypotonia (HP:0006829)2.62572988
48Fused cervical vertebrae (HP:0002949)2.62286809
49Down-sloping shoulders (HP:0200021)2.57251549
50Cellulitis (HP:0100658)2.56374869
51Aplasia/Hypoplasia of the hallux (HP:0008362)2.55545002
52Morphological abnormality of the middle ear (HP:0008609)2.54848118
53Neonatal respiratory distress (HP:0002643)2.54384602
54Abnormality of the middle phalanges of the toes (HP:0010183)2.51822677
55Aplasia/hypoplasia of the uterus (HP:0008684)2.50840675
56Abnormal number of erythroid precursors (HP:0012131)2.50711193
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50040524
58High pitched voice (HP:0001620)2.49735103
59Symphalangism affecting the phalanges of the hand (HP:0009773)2.49343211
60Short thumb (HP:0009778)2.48471829
61Poor head control (HP:0002421)2.45801194
62Decreased subcutaneous fat (HP:0001002)2.45684895
63Mitochondrial inheritance (HP:0001427)2.45135287
64Truncus arteriosus (HP:0001660)2.44978199
65Visceral angiomatosis (HP:0100761)2.43954878
66Pallor (HP:0000980)2.43591623
67Chromsome breakage (HP:0040012)2.43139691
68Microretrognathia (HP:0000308)2.42829594
69Hypoproteinemia (HP:0003075)2.42560593
703-Methylglutaconic aciduria (HP:0003535)2.42533986
71Broad metatarsal (HP:0001783)2.38763059
72Rectal fistula (HP:0100590)2.38577220
73Rectovaginal fistula (HP:0000143)2.38577220
74Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.38285500
75Pancreatic cysts (HP:0001737)2.35872293
76Hemangiomatosis (HP:0007461)2.32417345
77Pustule (HP:0200039)2.32166866
78Germ cell neoplasia (HP:0100728)2.32154302
79Abnormality of the distal phalanx of the thumb (HP:0009617)2.31283051
80Chorioretinal atrophy (HP:0000533)2.31061232
81Metaphyseal dysplasia (HP:0100255)2.30997070
82Type II lissencephaly (HP:0007260)2.29072230
83Aneurysm (HP:0002617)2.28632970
84Hyperacusis (HP:0010780)2.27943398
85Aplasia/Hypoplasia of the patella (HP:0006498)2.25901784
86Abnormality of subcutaneous fat tissue (HP:0001001)2.25348424
87Abnormal tarsal ossification (HP:0008369)2.23841344
88Horseshoe kidney (HP:0000085)2.22878964
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.22462330
90Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22292337
91Cerebral edema (HP:0002181)2.20630517
92Abnormal number of incisors (HP:0011064)2.19961439
93Short 4th metacarpal (HP:0010044)2.19534762
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19534762
95Increased CSF lactate (HP:0002490)2.18872340
96Abnormality of the phalanges of the 5th finger (HP:0004213)2.17979524
97Increased density of long bones (HP:0006392)2.15651520
98Abnormal platelet function (HP:0011869)2.14502184
99Impaired platelet aggregation (HP:0003540)2.14502184
100Glomerulonephritis (HP:0000099)2.11918373
101Aplasia/Hypoplasia involving the musculature (HP:0001460)2.11715818
102Bicuspid aortic valve (HP:0001647)2.11600653
103Abnormality of midbrain morphology (HP:0002418)2.10907721
104Molar tooth sign on MRI (HP:0002419)2.10907721
105Abnormality of the peritoneum (HP:0002585)2.10692189
106Partial duplication of the phalanx of hand (HP:0009999)2.09904707
107Macrocytic anemia (HP:0001972)2.06614989
108Abnormal rod and cone electroretinograms (HP:0008323)2.06301679
109Carpal synostosis (HP:0009702)2.05885837
110Cerebral aneurysm (HP:0004944)2.05592581
111Carpal bone hypoplasia (HP:0001498)2.05421140
112Abnormal ossification of hand bones (HP:0005921)2.05317875
113Elevated erythrocyte sedimentation rate (HP:0003565)2.04277150
114Abnormality of cochlea (HP:0000375)2.04073638
115Lumbar hyperlordosis (HP:0002938)2.03401478
116Keratoconus (HP:0000563)2.03139439
117Increased corneal curvature (HP:0100692)2.03139439
118Volvulus (HP:0002580)2.01967744
119Nephrotic syndrome (HP:0000100)2.01489571
120Metabolic alkalosis (HP:0200114)1.99692661
121Chronic otitis media (HP:0000389)1.99645949
122Prolonged bleeding time (HP:0003010)1.98380881
123Optic disc pallor (HP:0000543)1.97599993
124Neonatal short-limb short stature (HP:0008921)1.96574386
125Pancreatic fibrosis (HP:0100732)1.95299558
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.94909196
127Proteinuria (HP:0000093)1.94904316
128True hermaphroditism (HP:0010459)1.92699579
129Intestinal fistula (HP:0100819)1.92652199
130Flattened epiphyses (HP:0003071)1.92633897
131Thin bony cortex (HP:0002753)1.92360310
132Urethral obstruction (HP:0000796)1.92196886
133Hypoplasia of the radius (HP:0002984)1.90654569
134Oligomenorrhea (HP:0000876)1.89925343
135Hypoventilation (HP:0002791)1.88997453
136Abnormality of the carotid arteries (HP:0005344)1.88355640
137Adrenal hypoplasia (HP:0000835)1.88319594
138Patellar aplasia (HP:0006443)1.87830450
139Cystic liver disease (HP:0006706)1.87417597
140Congenital stationary night blindness (HP:0007642)1.86992408
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86611727
142Myositis (HP:0100614)1.86508806
143Vaginal fistula (HP:0004320)1.86430957
144Abnormal foot bone ossification (HP:0010675)1.85488527
145Abnormality of carpal bone ossification (HP:0006257)1.85332546
146Partial duplication of thumb phalanx (HP:0009944)1.84716941
147Abnormal hemoglobin (HP:0011902)1.83934950
148Renal agenesis (HP:0000104)1.83887890
149Methylmalonic acidemia (HP:0002912)1.81841034
150Polycythemia (HP:0001901)1.81642976
151Nasal polyposis (HP:0100582)1.81161387
152Limited elbow extension (HP:0001377)1.81092736
153Absent phalangeal crease (HP:0006109)1.80540323
154Abnormality of the renal cortex (HP:0011035)1.80031700
155Asplenia (HP:0001746)1.79340198
156Interstitial pulmonary disease (HP:0006530)1.77828593
157Synostosis involving bones of the hand (HP:0004278)1.77308796
158Lymphangioma (HP:0100764)1.76682309
159Breech presentation (HP:0001623)1.75699519
160Skin tags (HP:0010609)1.74533963
161Septate vagina (HP:0001153)1.74075104
162Triphalangeal thumb (HP:0001199)1.74022699
163Hematuria (HP:0000790)1.73930153
164Abnormality of the costochondral junction (HP:0000919)1.73464301
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.73347471
166Disproportionate tall stature (HP:0001519)1.73287253
167Absent radius (HP:0003974)1.73073181
168Ulnar bowing (HP:0003031)1.72991249
169Methylmalonic aciduria (HP:0012120)1.72140141
170Flat acetabular roof (HP:0003180)1.70647466
171Chest pain (HP:0100749)1.69421557
172Sclerocornea (HP:0000647)1.69341459
173Bony spicule pigmentary retinopathy (HP:0007737)1.68713855
174Morphological abnormality of the inner ear (HP:0011390)1.68599819
175Cleft eyelid (HP:0000625)1.68439461
176Short femoral neck (HP:0100864)1.68359657
177Rectal prolapse (HP:0002035)1.67812646
178Aplasia involving forearm bones (HP:0009822)1.67332458
179Absent forearm bone (HP:0003953)1.67332458
180Shallow orbits (HP:0000586)1.66668565
181Macroorchidism (HP:0000053)1.66130849
182Hypergonadotropic hypogonadism (HP:0000815)1.64158915
183Broad toe (HP:0001837)1.63433439
184Hyperalaninemia (HP:0003348)1.63380722
185Dilatation of the ascending aorta (HP:0005111)1.62057708
186Glomerulopathy (HP:0100820)1.61891252
187Abnormal hand bone ossification (HP:0010660)1.59093384
188Bladder diverticulum (HP:0000015)1.58070441
189Short phalanx of the thumb (HP:0009660)1.57167765
190Persistence of primary teeth (HP:0006335)1.54477917
191Abnormality of the parietal bone (HP:0002696)1.54181865
192Arterial tortuosity (HP:0005116)1.54129361
193Hepatoblastoma (HP:0002884)1.53962296
194Amaurosis fugax (HP:0100576)1.53953709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.95708072
2EEF2K3.94476732
3TGFBR13.87274408
4GRK13.84779240
5TIE13.71455746
6BCKDK3.63618891
7TGFBR23.28945574
8TRIB32.92778679
9PRKCI2.79733569
10MAP3K102.71101738
11MAP4K12.46246101
12LRRK22.39527866
13ADRBK22.38306392
14PKN22.34281940
15MYLK2.33241058
16NUAK12.26366330
17ZAK2.24765309
18CDK32.23254885
19STK392.19850648
20ERN12.17430271
21EPHB22.11359870
22MAP2K72.11115057
23TAF12.06225088
24FGFR41.99089975
25MAP2K31.96057921
26VRK21.93750667
27PAK41.87557824
28PTK61.85036347
29NME21.79787029
30STK101.79625567
31CDC71.79104947
32IRAK31.59771010
33SMG11.57407168
34MAP3K41.56943985
35BUB11.49931835
36MAP2K41.49827969
37MAP4K21.46724109
38ZAP701.45091659
39FGFR21.44680564
40MKNK11.44250885
41RET1.44038433
42PASK1.43202857
43MAP2K61.41352439
44RPS6KA41.40216645
45EPHA21.38114930
46ATR1.37311539
47EPHB11.29774766
48STK161.28050446
49AURKA1.22490759
50PHKG21.20922064
51PHKG11.20922064
52RPS6KB21.20495872
53MAP2K11.18850102
54PDGFRA1.17552279
55CAMK1D1.16597695
56KIT1.15506715
57TAOK31.14975602
58MAP3K71.14766788
59RIPK11.12506920
60OXSR11.10277863
61PAK21.09878683
62HIPK21.06338801
63PRKG21.06269699
64TBK11.06232142
65EIF2AK31.06152513
66INSRR1.04724382
67FGFR31.04599520
68GRK61.00920437
69BTK1.00074981
70ICK0.97524219
71JAK30.96924264
72CHEK20.96045425
73WNK40.93863764
74CAMK1G0.92688383
75TLK10.92070970
76CDK80.91458145
77BRAF0.90711452
78ILK0.90336602
79MAP3K90.88857179
80RPS6KA50.88266785
81EIF2AK10.86303524
82ALK0.86139581
83CLK10.85843491
84PLK10.85660573
85TXK0.85516501
86STK40.84975673
87MST40.84042715
88TRIM280.82954972
89MST1R0.82519451
90BMPR1B0.80570040
91PIM20.79656423
92PIM10.79605107
93MAPK40.79033128
94TTN0.78482800
95SCYL20.78237440
96PINK10.77969425
97DYRK30.77160276
98MAP2K20.77115433
99DYRK20.76614375
100MAP3K80.72924675
101MKNK20.70073502
102ITK0.69799659
103VRK10.69674075
104IKBKE0.69178526
105PRKCG0.68417991
106BRSK20.68341440
107STK30.65950975
108ABL20.65751261
109BLK0.65438525
110DAPK30.65208796
111MAP3K120.64691443
112WNK10.63117286
113TRPM70.62500050
114CSNK1A10.62265398
115KDR0.62147841
116CHEK10.60243157
117MAPK110.57374013
118MAPKAPK50.55705660
119PRKCE0.54769059
120CSNK2A10.53584740
121MATK0.53146181
122CSNK1G30.52647518
123PLK40.52462147
124AURKB0.52452093
125RPS6KA20.50087162
126EPHA30.49718173
127NTRK30.49677529
128NEK90.49236836
129MAPKAPK30.49223100
130CAMKK20.48487945
131TYRO30.47978501
132CDK60.47792459
133CDK40.46915701
134LMTK20.46524991
135BMX0.46345145
136PRKAA10.45928196
137MET0.44997693
138CDK90.44985886
139RPS6KA60.44805111
140IKBKB0.44009188
141CAMKK10.43645071
142SYK0.43640305
143CSNK1G10.43371424
144STK110.41098534
145ATM0.40878467
146RPS6KL10.40799758
147RPS6KC10.40799758
148PRKAA20.39490442
149LCK0.38826046
150PRKCD0.38363474
151CDK70.37422807
152PDPK10.37186354
153TNK20.37100438
154AKT20.37097313
155TYK20.36899824
156MAPK130.36866728
157ADRBK10.36527719
158HCK0.36502919
159MAP3K60.36234456
160JAK20.36134904
161NEK20.35925269
162PRKD20.35084502
163BRD40.35054130
164PIK3CA0.34728677
165MELK0.34440212
166NME10.33990047
167CDK190.33659390
168MTOR0.32159765
169ERBB20.31223446
170DYRK1B0.30322629
171MAPK90.29875732

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.53426941
2Sulfur relay system_Homo sapiens_hsa041223.98446662
3Sulfur metabolism_Homo sapiens_hsa009203.35953072
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.23128151
5Homologous recombination_Homo sapiens_hsa034403.10163582
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.76040236
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.47216428
8Oxidative phosphorylation_Homo sapiens_hsa001902.46662102
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.18427286
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.18057016
11Fanconi anemia pathway_Homo sapiens_hsa034602.13519440
12Chronic myeloid leukemia_Homo sapiens_hsa052201.97139775
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93288997
14Small cell lung cancer_Homo sapiens_hsa052221.87074567
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86331109
16Selenocompound metabolism_Homo sapiens_hsa004501.79258677
17Shigellosis_Homo sapiens_hsa051311.78988262
18Nitrogen metabolism_Homo sapiens_hsa009101.68637098
19Platelet activation_Homo sapiens_hsa046111.68243100
20RNA polymerase_Homo sapiens_hsa030201.67647107
21One carbon pool by folate_Homo sapiens_hsa006701.65408595
22Pyrimidine metabolism_Homo sapiens_hsa002401.63127953
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.62155706
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59924379
25ECM-receptor interaction_Homo sapiens_hsa045121.59186271
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57292850
27B cell receptor signaling pathway_Homo sapiens_hsa046621.54933949
28Parkinsons disease_Homo sapiens_hsa050121.53874732
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53242363
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51773511
31Focal adhesion_Homo sapiens_hsa045101.51124065
32N-Glycan biosynthesis_Homo sapiens_hsa005101.49748503
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.47364306
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.43095973
35Linoleic acid metabolism_Homo sapiens_hsa005911.41973790
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.41068803
37Pancreatic cancer_Homo sapiens_hsa052121.40298933
38Acute myeloid leukemia_Homo sapiens_hsa052211.39207008
39Osteoclast differentiation_Homo sapiens_hsa043801.39187095
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39006521
41Nucleotide excision repair_Homo sapiens_hsa034201.36992883
42Phototransduction_Homo sapiens_hsa047441.36411695
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35554070
44VEGF signaling pathway_Homo sapiens_hsa043701.34213839
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32273726
46Hepatitis B_Homo sapiens_hsa051611.31748593
47Leishmaniasis_Homo sapiens_hsa051401.30632367
48Toxoplasmosis_Homo sapiens_hsa051451.29897405
49Huntingtons disease_Homo sapiens_hsa050161.29234044
50Renin-angiotensin system_Homo sapiens_hsa046141.25618502
51Spliceosome_Homo sapiens_hsa030401.25394658
52Retinol metabolism_Homo sapiens_hsa008301.25317645
53Protein export_Homo sapiens_hsa030601.25040267
54Alzheimers disease_Homo sapiens_hsa050101.24090734
55Proteoglycans in cancer_Homo sapiens_hsa052051.23506532
56Primary immunodeficiency_Homo sapiens_hsa053401.22784027
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22418097
58DNA replication_Homo sapiens_hsa030301.22083945
59MicroRNAs in cancer_Homo sapiens_hsa052061.21092414
60T cell receptor signaling pathway_Homo sapiens_hsa046601.18848699
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17703598
62Basal transcription factors_Homo sapiens_hsa030221.16339006
63Salmonella infection_Homo sapiens_hsa051321.13422839
64Pertussis_Homo sapiens_hsa051331.12703817
65Colorectal cancer_Homo sapiens_hsa052101.12077914
66Apoptosis_Homo sapiens_hsa042101.11951697
67TNF signaling pathway_Homo sapiens_hsa046681.10266655
68Prolactin signaling pathway_Homo sapiens_hsa049171.09478319
69Herpes simplex infection_Homo sapiens_hsa051681.09210885
70Non-small cell lung cancer_Homo sapiens_hsa052231.07911655
71Amoebiasis_Homo sapiens_hsa051461.07133619
72Vitamin B6 metabolism_Homo sapiens_hsa007501.06717878
73Fat digestion and absorption_Homo sapiens_hsa049751.06685619
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05223485
75Steroid hormone biosynthesis_Homo sapiens_hsa001401.04099372
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03841620
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03669395
78Bladder cancer_Homo sapiens_hsa052191.03300845
79Neurotrophin signaling pathway_Homo sapiens_hsa047221.02524529
80HTLV-I infection_Homo sapiens_hsa051661.02028233
81NF-kappa B signaling pathway_Homo sapiens_hsa040641.00394307
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.98778973
83Pathways in cancer_Homo sapiens_hsa052000.98194341
84Mismatch repair_Homo sapiens_hsa034300.97036332
85Butanoate metabolism_Homo sapiens_hsa006500.96344953
86Notch signaling pathway_Homo sapiens_hsa043300.95487447
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95244931
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94555096
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94265302
90Base excision repair_Homo sapiens_hsa034100.93225091
91Lysine degradation_Homo sapiens_hsa003100.92064055
92Insulin resistance_Homo sapiens_hsa049310.91805960
93Chemical carcinogenesis_Homo sapiens_hsa052040.91493538
94Caffeine metabolism_Homo sapiens_hsa002320.90067132
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89807394
96Basal cell carcinoma_Homo sapiens_hsa052170.88571737
97Hepatitis C_Homo sapiens_hsa051600.88316299
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.88227840
99Protein digestion and absorption_Homo sapiens_hsa049740.86486528
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86469886
101Axon guidance_Homo sapiens_hsa043600.85881577
102Rap1 signaling pathway_Homo sapiens_hsa040150.85693939
103Tyrosine metabolism_Homo sapiens_hsa003500.84501729
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.84086541
105Cell cycle_Homo sapiens_hsa041100.83904118
106Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82285993
107Glycerolipid metabolism_Homo sapiens_hsa005610.81982304
108Influenza A_Homo sapiens_hsa051640.81397569
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81062214
110Insulin secretion_Homo sapiens_hsa049110.80893062
111FoxO signaling pathway_Homo sapiens_hsa040680.80717707
112Purine metabolism_Homo sapiens_hsa002300.80020446
113Hematopoietic cell lineage_Homo sapiens_hsa046400.78916040
114Collecting duct acid secretion_Homo sapiens_hsa049660.78463732
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.78009869
116RNA transport_Homo sapiens_hsa030130.77786934
117Cardiac muscle contraction_Homo sapiens_hsa042600.76778332
118Viral carcinogenesis_Homo sapiens_hsa052030.76093493
119Starch and sucrose metabolism_Homo sapiens_hsa005000.75721707
120Steroid biosynthesis_Homo sapiens_hsa001000.74625818
121Glioma_Homo sapiens_hsa052140.71569147
122Viral myocarditis_Homo sapiens_hsa054160.70922672
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70014825
124Proteasome_Homo sapiens_hsa030500.69931641
125Tryptophan metabolism_Homo sapiens_hsa003800.69895109
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68344390
127Measles_Homo sapiens_hsa051620.68306200
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68293700
129Tuberculosis_Homo sapiens_hsa051520.66127149
130Non-homologous end-joining_Homo sapiens_hsa034500.66111729
131Metabolic pathways_Homo sapiens_hsa011000.65847701
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65357153
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65247496
134Melanoma_Homo sapiens_hsa052180.63825799
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63672406
136Antigen processing and presentation_Homo sapiens_hsa046120.62717349
137Tight junction_Homo sapiens_hsa045300.61838968
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61756440
139Galactose metabolism_Homo sapiens_hsa000520.60518771
140Thyroid cancer_Homo sapiens_hsa052160.60077868
141ErbB signaling pathway_Homo sapiens_hsa040120.59802517
142Ether lipid metabolism_Homo sapiens_hsa005650.58922696
143Systemic lupus erythematosus_Homo sapiens_hsa053220.57925157
144Folate biosynthesis_Homo sapiens_hsa007900.56968621
145Epstein-Barr virus infection_Homo sapiens_hsa051690.55048909
146Mineral absorption_Homo sapiens_hsa049780.54777724
147HIF-1 signaling pathway_Homo sapiens_hsa040660.53464968
148Prostate cancer_Homo sapiens_hsa052150.53083438
149Adherens junction_Homo sapiens_hsa045200.52486340
150Chemokine signaling pathway_Homo sapiens_hsa040620.51666085
151Endometrial cancer_Homo sapiens_hsa052130.51428047
152p53 signaling pathway_Homo sapiens_hsa041150.51412705
153Hedgehog signaling pathway_Homo sapiens_hsa043400.51322653
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50776927
155RNA degradation_Homo sapiens_hsa030180.48250522
156Peroxisome_Homo sapiens_hsa041460.47794023
157Ras signaling pathway_Homo sapiens_hsa040140.46297318
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.44884206
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44380287
160Malaria_Homo sapiens_hsa051440.43562212
161Legionellosis_Homo sapiens_hsa051340.43187708
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.42746445
163Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42257210
164GnRH signaling pathway_Homo sapiens_hsa049120.42080550
165Ovarian steroidogenesis_Homo sapiens_hsa049130.40396894
166Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40001623
167Olfactory transduction_Homo sapiens_hsa047400.36166158
168Type II diabetes mellitus_Homo sapiens_hsa049300.35068869
169ABC transporters_Homo sapiens_hsa020100.33757932
170Regulation of autophagy_Homo sapiens_hsa041400.23730653
171Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23434507
172Taste transduction_Homo sapiens_hsa047420.23134014
173Dorso-ventral axis formation_Homo sapiens_hsa043200.22414777
174Pancreatic secretion_Homo sapiens_hsa049720.22031485
175Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21997194
176Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.21435905
177TGF-beta signaling pathway_Homo sapiens_hsa043500.21334002
178Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20352114
179Morphine addiction_Homo sapiens_hsa050320.19591085
180Primary bile acid biosynthesis_Homo sapiens_hsa001200.19431584

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