FOXD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.05375642
2regulation of gene silencing by RNA (GO:0060966)5.95676152
3regulation of posttranscriptional gene silencing (GO:0060147)5.95676152
4regulation of gene silencing by miRNA (GO:0060964)5.95676152
5transcription from mitochondrial promoter (GO:0006390)5.75061959
6establishment of apical/basal cell polarity (GO:0035089)5.22205616
7replication fork processing (GO:0031297)5.06274365
8embryonic process involved in female pregnancy (GO:0060136)5.02912448
9histone H4-K12 acetylation (GO:0043983)4.95423061
10establishment of integrated proviral latency (GO:0075713)4.93093720
11somatic diversification of immune receptors via somatic mutation (GO:0002566)4.84345100
12somatic hypermutation of immunoglobulin genes (GO:0016446)4.84345100
13protein complex localization (GO:0031503)4.76551018
14L-serine metabolic process (GO:0006563)4.64098604
15formation of translation preinitiation complex (GO:0001731)4.60050978
16establishment of monopolar cell polarity (GO:0061162)4.51137577
17establishment or maintenance of monopolar cell polarity (GO:0061339)4.51137577
18maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.49273226
19mitochondrial DNA metabolic process (GO:0032042)4.41483450
20proline metabolic process (GO:0006560)4.28063476
21pre-miRNA processing (GO:0031054)4.24002009
22heterochromatin organization (GO:0070828)4.17941886
23mitotic sister chromatid segregation (GO:0000070)4.17191134
24chromatin remodeling at centromere (GO:0031055)4.16416822
25regulation of translational fidelity (GO:0006450)4.09869534
26protein localization to kinetochore (GO:0034501)4.07535815
27negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.01812515
28CENP-A containing nucleosome assembly (GO:0034080)4.00455638
29DNA deamination (GO:0045006)3.97862247
30positive regulation of protein homooligomerization (GO:0032464)3.95504496
31cellular protein complex localization (GO:0034629)3.87555854
32anterior/posterior axis specification, embryo (GO:0008595)3.86481728
33regulation of hippo signaling (GO:0035330)3.82053125
34regulation of integrin activation (GO:0033623)3.81956559
35regulation of nuclear cell cycle DNA replication (GO:0033262)3.80667844
36DNA strand renaturation (GO:0000733)3.68577049
37DNA replication-dependent nucleosome assembly (GO:0006335)3.68532024
38DNA replication-dependent nucleosome organization (GO:0034723)3.68532024
39mitotic metaphase plate congression (GO:0007080)3.67872574
40DNA replication-independent nucleosome organization (GO:0034724)3.65185342
41DNA replication-independent nucleosome assembly (GO:0006336)3.65185342
42establishment of viral latency (GO:0019043)3.63155089
43histone H4-K5 acetylation (GO:0043981)3.62967665
44histone H4-K8 acetylation (GO:0043982)3.62967665
45determination of adult lifespan (GO:0008340)3.59492928
46mitotic G1 DNA damage checkpoint (GO:0031571)3.59412328
47IMP biosynthetic process (GO:0006188)3.58977135
48histone exchange (GO:0043486)3.57968633
49histone arginine methylation (GO:0034969)3.53588327
50nodal signaling pathway (GO:0038092)3.53578341
51positive regulation of developmental pigmentation (GO:0048087)3.53351559
52paraxial mesoderm development (GO:0048339)3.50271632
53negative regulation of telomerase activity (GO:0051974)3.50045459
54sister chromatid segregation (GO:0000819)3.49870038
55ribosome biogenesis (GO:0042254)3.46752954
56spliceosomal tri-snRNP complex assembly (GO:0000244)3.46513752
57negative regulation of chromosome segregation (GO:0051985)3.39731828
58ribosomal small subunit biogenesis (GO:0042274)3.39705517
59negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.37307906
60negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.37307906
61negative regulation of mitotic sister chromatid segregation (GO:0033048)3.37307906
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.37307906
63negative regulation of sister chromatid segregation (GO:0033046)3.37307906
64notochord development (GO:0030903)3.36157750
65IMP metabolic process (GO:0046040)3.34960935
66regulation of double-strand break repair (GO:2000779)3.34328275
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33655415
68regulation of telomere maintenance via telomerase (GO:0032210)3.33303373
69DNA unwinding involved in DNA replication (GO:0006268)3.31958274
70regulation of protein homooligomerization (GO:0032462)3.30646936
71DNA duplex unwinding (GO:0032508)3.29030939
72negative regulation of cell cycle arrest (GO:0071157)3.29019084
73telomere maintenance via semi-conservative replication (GO:0032201)3.28992685
74DNA geometric change (GO:0032392)3.27736847
75regulation of gene silencing (GO:0060968)3.27693768
76somite rostral/caudal axis specification (GO:0032525)3.26422738
77establishment of protein localization to mitochondrial membrane (GO:0090151)3.25075374
78viral mRNA export from host cell nucleus (GO:0046784)3.25026949
79apoptotic process involved in morphogenesis (GO:0060561)3.24887729
80mRNA cleavage (GO:0006379)3.24802723
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23341327
82regulation of mitotic spindle checkpoint (GO:1903504)3.23341327
83intracellular estrogen receptor signaling pathway (GO:0030520)3.22254262
84DNA strand elongation involved in DNA replication (GO:0006271)3.19053677
85regulation of cell fate specification (GO:0042659)3.18633384
86purine nucleobase biosynthetic process (GO:0009113)3.18278621
87regulation of double-strand break repair via homologous recombination (GO:0010569)3.18204169
88chromatin assembly (GO:0031497)3.18050365
89regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.16532671
90base-excision repair (GO:0006284)3.16435980
91mitotic G1/S transition checkpoint (GO:0044819)3.15992481
92ATP-dependent chromatin remodeling (GO:0043044)3.15589993
93nuclear pore organization (GO:0006999)3.15457811
94chromatin assembly or disassembly (GO:0006333)3.13840877
95rRNA transcription (GO:0009303)3.13719081
96ribosome assembly (GO:0042255)3.13477117
97serine family amino acid biosynthetic process (GO:0009070)3.13377579
98termination of RNA polymerase III transcription (GO:0006386)3.13032981
99transcription elongation from RNA polymerase III promoter (GO:0006385)3.13032981
100maturation of SSU-rRNA (GO:0030490)3.12345990
101regulation of sister chromatid cohesion (GO:0007063)3.11749572
102spindle checkpoint (GO:0031577)3.10784923
103ribosomal small subunit assembly (GO:0000028)3.08165182
104positive regulation of SMAD protein import into nucleus (GO:0060391)3.08064803
105G1 DNA damage checkpoint (GO:0044783)3.07602256
106negative regulation of androgen receptor signaling pathway (GO:0060766)3.06948634
107DNA replication initiation (GO:0006270)3.04061330
108negative regulation of mRNA processing (GO:0050686)3.03557325
109mitotic spindle checkpoint (GO:0071174)3.03475977
110regulation of chromosome segregation (GO:0051983)3.03425026
111nucleobase biosynthetic process (GO:0046112)3.03254032
112mitochondrial RNA metabolic process (GO:0000959)3.02970473
113embryonic camera-type eye development (GO:0031076)3.01570699
114nuclear pore complex assembly (GO:0051292)3.01531700
115cullin deneddylation (GO:0010388)3.01355066
116lung-associated mesenchyme development (GO:0060484)3.01126183
117mitotic nuclear envelope disassembly (GO:0007077)3.00705222
118protein localization to chromosome, centromeric region (GO:0071459)3.00699472
119mitotic chromosome condensation (GO:0007076)3.00656018
120polarized epithelial cell differentiation (GO:0030859)2.99709479
121mitochondrial DNA replication (GO:0006264)2.99653411
122termination of RNA polymerase II transcription (GO:0006369)2.99338667
123regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98710491
124DNA strand elongation (GO:0022616)2.98557369
125pseudouridine synthesis (GO:0001522)2.98159274
126muscle organ morphogenesis (GO:0048644)2.97422671
127regulation of helicase activity (GO:0051095)2.96904130
128viral transcription (GO:0019083)2.96808934
129negative regulation of gene silencing (GO:0060969)2.96681050
130positive regulation of mitotic sister chromatid separation (GO:1901970)2.95842650
131positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95842650
132positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95842650
133oxidative demethylation (GO:0070989)2.95813817
134chaperone-mediated protein transport (GO:0072321)2.94969920
135spindle assembly (GO:0051225)2.93727535
136translational termination (GO:0006415)2.93284898
137DNA replication checkpoint (GO:0000076)2.93152470
138peptidyl-arginine omega-N-methylation (GO:0035247)2.92928047
139negative regulation of RNA splicing (GO:0033119)2.92912041
140poly(A)+ mRNA export from nucleus (GO:0016973)2.92157653
141mitotic spindle assembly checkpoint (GO:0007094)2.92067400
142regulation of histone H3-K9 methylation (GO:0051570)2.90791306
143positive regulation of chromosome segregation (GO:0051984)2.89841394
144negative regulation of histone methylation (GO:0031061)2.89488717
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.87648811
146nucleotide-excision repair, DNA gap filling (GO:0006297)2.87607235
147negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86781061
148regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86476007
149regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86476007
150regulation of mitotic sister chromatid separation (GO:0010965)2.85235828
151regulation of mitotic sister chromatid segregation (GO:0033047)2.85235828
152regulation of sister chromatid segregation (GO:0033045)2.85235828
153L-alpha-amino acid transmembrane transport (GO:1902475)2.85184469
154spindle assembly checkpoint (GO:0071173)2.84586616
155metaphase plate congression (GO:0051310)2.84567797
156spliceosomal snRNP assembly (GO:0000387)2.83316356
157DNA damage response, detection of DNA damage (GO:0042769)2.82490601
158negative regulation of mitosis (GO:0045839)2.81947296
159regulation of stem cell maintenance (GO:2000036)2.78296047
160mitotic sister chromatid cohesion (GO:0007064)2.77472451
161telomere maintenance via telomerase (GO:0007004)2.74993766
162nucleosome disassembly (GO:0006337)2.74386119
163protein-DNA complex disassembly (GO:0032986)2.74386119
164telomere maintenance via recombination (GO:0000722)2.74147252
165kinetochore organization (GO:0051383)2.73767921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.22707453
2* KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.25021171
3* KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.25021171
4* KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.25021171
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.73876491
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.26236065
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.00418492
8* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.00239041
9* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.98671447
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98350255
11* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.91619434
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.89185658
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.81076814
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76587664
15* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.75077492
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.60282984
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.58549833
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.31563689
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28635241
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25162699
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24016342
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.18626055
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.18393819
24STAT3_1855785_ChIP-Seq_MESCs_Mouse2.16220588
25* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.15410394
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13784239
27POU5F1_16518401_ChIP-PET_MESCs_Mouse2.12582549
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11924504
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10745518
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.08497081
31* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.05772934
32* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.98111251
33NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.96216805
34AR_21909140_ChIP-Seq_LNCAP_Human1.96105259
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95394772
36NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.94300841
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89140208
38* SOX2_16153702_ChIP-ChIP_HESCs_Human1.89004843
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.85702686
40* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83965530
41* NANOG_16153702_ChIP-ChIP_HESCs_Human1.81638885
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76366948
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74734139
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74493763
45* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64529751
46NANOG_21062744_ChIP-ChIP_HESCs_Human1.62521736
47SOX2_18692474_ChIP-Seq_MESCs_Mouse1.55848288
48NANOG_18692474_ChIP-Seq_MESCs_Mouse1.54995079
49SOX2_18692474_ChIP-Seq_MEFs_Mouse1.54396215
50FOXP3_21729870_ChIP-Seq_TREG_Human1.54216392
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.53721729
52POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.52758206
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51446804
54MYC_22102868_ChIP-Seq_BL_Human1.49164168
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48012490
56* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47893010
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47293444
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.46975168
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46839043
60NANOG_18692474_ChIP-Seq_MEFs_Mouse1.45907282
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.45535154
62OCT4_18692474_ChIP-Seq_MEFs_Mouse1.43618814
63* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.43189050
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41483014
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40993202
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40205781
67* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37388191
68* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36358510
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34747592
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33707543
71XRN2_22483619_ChIP-Seq_HELA_Human1.33464219
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.32926659
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32674645
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32330812
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32171467
76* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.30853795
77MYC_18940864_ChIP-ChIP_HL60_Human1.28915061
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28209230
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26821842
80ELK1_19687146_ChIP-ChIP_HELA_Human1.26238844
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25226421
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24226612
83VDR_21846776_ChIP-Seq_THP-1_Human1.21866280
84* NANOG_16518401_ChIP-PET_MESCs_Mouse1.15017806
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.14295561
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14112913
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12956691
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12611942
89EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10184068
90KAP1_27257070_Chip-Seq_ESCs_Mouse1.09880348
91* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09835405
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09615586
93KDM5A_27292631_Chip-Seq_BREAST_Human1.09488512
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09191630
95VDR_23849224_ChIP-Seq_CD4+_Human1.08986012
96TTF2_22483619_ChIP-Seq_HELA_Human1.07544708
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07248278
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.06747970
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06558721
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05004653
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.03934057
102GABP_19822575_ChIP-Seq_HepG2_Human1.02621872
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02330851
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02328351
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99166295
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98549460
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97917418
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95543808
109* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93900852
110* LXR_22292898_ChIP-Seq_THP-1_Human0.93647121
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92741193
112IRF1_19129219_ChIP-ChIP_H3396_Human0.92546083
113SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91015900
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90536088
115DCP1A_22483619_ChIP-Seq_HELA_Human0.90487549
116ZNF263_19887448_ChIP-Seq_K562_Human0.89920178
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89810525
118* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89407275
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89136991
120* RACK7_27058665_Chip-Seq_MCF-7_Human0.89086737
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.88458236
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88148368
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88092262
124YY1_22570637_ChIP-Seq_MALME-3M_Human0.86858640
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.86664789
126SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86366172
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85723602
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84983279
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84668924
130* CHD1_26751641_Chip-Seq_LNCaP_Human0.83943699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.36347228
2MP0003890_abnormal_embryonic-extraembry3.50591614
3MP0004957_abnormal_blastocyst_morpholog3.36488840
4MP0010030_abnormal_orbit_morphology3.28088982
5MP0002653_abnormal_ependyma_morphology3.02237996
6MP0004133_heterotaxia2.86097585
7MP0010352_gastrointestinal_tract_polyps2.76014720
8MP0010094_abnormal_chromosome_stability2.74676263
9MP0003111_abnormal_nucleus_morphology2.57030578
10MP0003283_abnormal_digestive_organ2.48018389
11MP0009672_abnormal_birth_weight2.42094462
12MP0003119_abnormal_digestive_system2.37061542
13MP0003077_abnormal_cell_cycle2.29278358
14MP0003693_abnormal_embryo_hatching2.18198737
15MP0001188_hyperpigmentation2.16343992
16MP0001293_anophthalmia2.14789362
17MP0009278_abnormal_bone_marrow2.10280570
18MP0006292_abnormal_olfactory_placode2.08354883
19MP0004264_abnormal_extraembryonic_tissu2.06583451
20MP0005171_absent_coat_pigmentation2.06433571
21MP0005380_embryogenesis_phenotype2.00098148
22MP0001672_abnormal_embryogenesis/_devel2.00098148
23* MP0002085_abnormal_embryonic_tissue1.96802948
24* MP0002084_abnormal_developmental_patter1.95829403
25MP0002938_white_spotting1.94487187
26MP0003718_maternal_effect1.90372831
27MP0003136_yellow_coat_color1.85665750
28* MP0002086_abnormal_extraembryonic_tissu1.85134448
29* MP0000350_abnormal_cell_proliferation1.80585010
30MP0001697_abnormal_embryo_size1.77993547
31MP0001730_embryonic_growth_arrest1.77481031
32MP0004197_abnormal_fetal_growth/weight/1.76822328
33MP0003937_abnormal_limbs/digits/tail_de1.75103406
34MP0008058_abnormal_DNA_repair1.74236323
35* MP0008932_abnormal_embryonic_tissue1.69927889
36MP0003984_embryonic_growth_retardation1.68761524
37MP0002088_abnormal_embryonic_growth/wei1.66441029
38MP0004233_abnormal_muscle_weight1.66207615
39MP0002249_abnormal_larynx_morphology1.60733275
40MP0005076_abnormal_cell_differentiation1.56231606
41MP0003786_premature_aging1.53174181
42MP0008877_abnormal_DNA_methylation1.52013742
43MP0003705_abnormal_hypodermis_morpholog1.51570738
44MP0005075_abnormal_melanosome_morpholog1.51225983
45MP0000537_abnormal_urethra_morphology1.49961621
46MP0002254_reproductive_system_inflammat1.45530331
47MP0005377_hearing/vestibular/ear_phenot1.39304474
48MP0003878_abnormal_ear_physiology1.39304474
49MP0000566_synostosis1.38901728
50MP0000579_abnormal_nail_morphology1.38220124
51MP0003941_abnormal_skin_development1.36420928
52MP0002332_abnormal_exercise_endurance1.35125389
53* MP0002080_prenatal_lethality1.34686856
54MP0000762_abnormal_tongue_morphology1.33420783
55MP0009379_abnormal_foot_pigmentation1.31092092
56MP0002111_abnormal_tail_morphology1.26255813
57MP0001346_abnormal_lacrimal_gland1.24988234
58MP0000490_abnormal_crypts_of1.19121379
59MP0001849_ear_inflammation1.17545925
60MP0002269_muscular_atrophy1.15848154
61MP0002932_abnormal_joint_morphology1.15780901
62MP0005394_taste/olfaction_phenotype1.15736337
63MP0005499_abnormal_olfactory_system1.15736337
64MP0003453_abnormal_keratinocyte_physiol1.15113296
65MP0006072_abnormal_retinal_apoptosis1.14583636
66MP0002009_preneoplasia1.10913892
67MP0001348_abnormal_lacrimal_gland1.10824349
68MP0005266_abnormal_metabolism1.10225362
69MP0003567_abnormal_fetal_cardiomyocyte1.09737292
70MP0000516_abnormal_urinary_system1.08715780
71MP0005367_renal/urinary_system_phenotyp1.08715780
72* MP0000432_abnormal_head_morphology1.07482075
73MP0002114_abnormal_axial_skeleton1.06181445
74MP0002233_abnormal_nose_morphology1.05660776
75MP0008007_abnormal_cellular_replicative1.03819868
76MP0009250_abnormal_appendicular_skeleto1.02843512
77MP0002210_abnormal_sex_determination1.02629137
78MP0000049_abnormal_middle_ear1.01262734
79MP0002092_abnormal_eye_morphology1.01260188
80MP0003123_paternal_imprinting1.01199459
81MP0000678_abnormal_parathyroid_gland1.01138555
82MP0004858_abnormal_nervous_system1.00321527
83MP0004272_abnormal_basement_membrane1.00235823
84* MP0003755_abnormal_palate_morphology0.99070493
85MP0003942_abnormal_urinary_system0.98537503
86MP0003315_abnormal_perineum_morphology0.98059586
87MP0002697_abnormal_eye_size0.96935419
88MP0002796_impaired_skin_barrier0.96310200
89* MP0003935_abnormal_craniofacial_develop0.95237304
90MP0009053_abnormal_anal_canal0.95216962
91MP0003806_abnormal_nucleotide_metabolis0.94599389
92* MP0000313_abnormal_cell_death0.94016455
93MP0003861_abnormal_nervous_system0.91190940
94MP0005623_abnormal_meninges_morphology0.89862901
95MP0006035_abnormal_mitochondrial_morpho0.89733283
96MP0002282_abnormal_trachea_morphology0.89389658
97MP0001299_abnormal_eye_distance/0.89068738
98MP0010307_abnormal_tumor_latency0.87504315
99MP0002019_abnormal_tumor_incidence0.87399122
100MP0000371_diluted_coat_color0.86877604
101MP0002127_abnormal_cardiovascular_syste0.86554444
102MP0005397_hematopoietic_system_phenotyp0.85944339
103MP0001545_abnormal_hematopoietic_system0.85944339
104MP0003566_abnormal_cell_adhesion0.85501940
105MP0009703_decreased_birth_body0.85279838
106MP0005508_abnormal_skeleton_morphology0.84542317
107MP0003938_abnormal_ear_development0.84479550
108MP0001286_abnormal_eye_development0.83330392
109MP0008770_decreased_survivor_rate0.82762476
110* MP0002116_abnormal_craniofacial_bone0.82286885
111MP0005023_abnormal_wound_healing0.81839316
112MP0003121_genomic_imprinting0.80708985
113MP0001145_abnormal_male_reproductive0.80243048
114MP0002075_abnormal_coat/hair_pigmentati0.79192744
115MP0005501_abnormal_skin_physiology0.78863959
116MP0008995_early_reproductive_senescence0.76755906
117MP0000462_abnormal_digestive_system0.76279654
118MP0000653_abnormal_sex_gland0.76063988
119MP0005391_vision/eye_phenotype0.75772829
120MP0000470_abnormal_stomach_morphology0.75520661
121MP0001929_abnormal_gametogenesis0.75178288
122* MP0002925_abnormal_cardiovascular_devel0.75175568
123MP0002089_abnormal_postnatal_growth/wei0.74597349
124MP0000428_abnormal_craniofacial_morphol0.73679745
125MP0004185_abnormal_adipocyte_glucose0.71999845
126MP0002160_abnormal_reproductive_system0.71056205
127MP0009697_abnormal_copulation0.70424582
128MP0003115_abnormal_respiratory_system0.69815396
129MP0000631_abnormal_neuroendocrine_gland0.68997312
130MP0003186_abnormal_redox_activity0.67159757
131MP0003385_abnormal_body_wall0.65822427
132MP0003698_abnormal_male_reproductive0.65797844
133* MP0002081_perinatal_lethality0.65261354
134MP0002161_abnormal_fertility/fecundity0.63803500
135* MP0002751_abnormal_autonomic_nervous0.62229841

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.80026293
2Rectal fistula (HP:0100590)4.76293719
3Rectovaginal fistula (HP:0000143)4.76293719
4Ependymoma (HP:0002888)4.36028990
5Intestinal fistula (HP:0100819)4.33202816
6Aplasia/hypoplasia of the humerus (HP:0006507)4.28698749
7Short humerus (HP:0005792)4.24767232
8Vaginal fistula (HP:0004320)4.11212376
9Hypochromic microcytic anemia (HP:0004840)4.10136902
10Septo-optic dysplasia (HP:0100842)3.97732847
11Birth length less than 3rd percentile (HP:0003561)3.77210482
12Abnormality of the astrocytes (HP:0100707)3.74481194
13Astrocytoma (HP:0009592)3.74481194
14Concave nail (HP:0001598)3.69522792
15Abnormality of the lower motor neuron (HP:0002366)3.48612468
16Absent radius (HP:0003974)3.46474333
17Rhabdomyosarcoma (HP:0002859)3.35990550
18Reticulocytopenia (HP:0001896)3.25815775
19Tongue fasciculations (HP:0001308)3.25526325
20Aplasia involving forearm bones (HP:0009822)3.24443053
21Absent forearm bone (HP:0003953)3.24443053
22Abnormality of the labia minora (HP:0012880)3.24353183
23Facial hemangioma (HP:0000329)3.22737464
24Neoplasm of striated muscle (HP:0009728)3.16460901
25Neoplasm of the oral cavity (HP:0100649)3.16212119
26Selective tooth agenesis (HP:0001592)3.10817302
27Muscle fibrillation (HP:0010546)3.02454845
28Abnormality of homocysteine metabolism (HP:0010919)2.97812539
29Homocystinuria (HP:0002156)2.97812539
30Bilateral microphthalmos (HP:0007633)2.97014511
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.96408134
32Annular pancreas (HP:0001734)2.91660428
33Maternal diabetes (HP:0009800)2.91304648
34Supernumerary spleens (HP:0009799)2.87040601
35Glioma (HP:0009733)2.81359754
36Vertebral fusion (HP:0002948)2.73415336
37Abnormal lung lobation (HP:0002101)2.72387744
38Ulnar bowing (HP:0003031)2.72238141
39Shawl scrotum (HP:0000049)2.67513268
40Orthostatic hypotension (HP:0001278)2.67288082
41Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.62557905
42Vertebral hypoplasia (HP:0008417)2.62557905
43Absent thumb (HP:0009777)2.59708555
44Ectopic kidney (HP:0000086)2.57595751
45Abnormal hemoglobin (HP:0011902)2.56741192
46Absent septum pellucidum (HP:0001331)2.53450248
47Patellar aplasia (HP:0006443)2.52638747
48Abdominal situs inversus (HP:0003363)2.52452294
49Abnormality of abdominal situs (HP:0011620)2.52452294
50Medulloblastoma (HP:0002885)2.52429473
51Partial duplication of thumb phalanx (HP:0009944)2.47618983
52Basal cell carcinoma (HP:0002671)2.46610105
53Abnormality of cells of the erythroid lineage (HP:0012130)2.46364945
54Trismus (HP:0000211)2.46252336
55Facial cleft (HP:0002006)2.46114259
56Missing ribs (HP:0000921)2.45366860
57Abnormality of the septum pellucidum (HP:0007375)2.44612900
58Intestinal atresia (HP:0011100)2.43885062
59Broad alveolar ridges (HP:0000187)2.43062871
60Abnormal number of incisors (HP:0011064)2.41262015
61Fused cervical vertebrae (HP:0002949)2.40026156
62Abnormal number of erythroid precursors (HP:0012131)2.38943934
63Multiple enchondromatosis (HP:0005701)2.38640944
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37191658
65Choanal stenosis (HP:0000452)2.36939513
66Abnormality of the ileum (HP:0001549)2.35499851
67Nephroblastoma (Wilms tumor) (HP:0002667)2.33053169
68Breast aplasia (HP:0100783)2.32160301
69Increased IgM level (HP:0003496)2.31993931
70Breast hypoplasia (HP:0003187)2.29568962
71Spinal muscular atrophy (HP:0007269)2.28828644
72Aplasia/Hypoplasia of the patella (HP:0006498)2.28345474
73Abnormality of the salivary glands (HP:0010286)2.28310219
74Spastic diplegia (HP:0001264)2.26282736
75Esophageal atresia (HP:0002032)2.24447899
76Gastrointestinal atresia (HP:0002589)2.24265252
77Morphological abnormality of the inner ear (HP:0011390)2.22939913
78Turricephaly (HP:0000262)2.21121635
79Progressive muscle weakness (HP:0003323)2.19815995
80Horseshoe kidney (HP:0000085)2.19375308
81Aplasia/Hypoplasia of the breasts (HP:0010311)2.18214433
82Large earlobe (HP:0009748)2.16701816
83Partial duplication of the phalanx of hand (HP:0009999)2.16262689
84Macrocytic anemia (HP:0001972)2.16112112
85Peripheral hypomyelination (HP:0007182)2.15133357
86Volvulus (HP:0002580)2.14606758
87White forelock (HP:0002211)2.14592727
88Calcaneovalgus deformity (HP:0001848)2.13966689
89Duplication of thumb phalanx (HP:0009942)2.13929078
90Embryonal renal neoplasm (HP:0011794)2.13916800
91Triphalangeal thumb (HP:0001199)2.12680762
92Supernumerary ribs (HP:0005815)2.12284125
93Carpal bone hypoplasia (HP:0001498)2.11609497
94Alopecia of scalp (HP:0002293)2.10263596
95Chromsome breakage (HP:0040012)2.09967906
96Cortical dysplasia (HP:0002539)2.08137700
97Increased nuchal translucency (HP:0010880)2.07161844
98Hemivertebrae (HP:0002937)2.06855535
99Impulsivity (HP:0100710)2.06087397
100Abnormality of the lacrimal duct (HP:0011481)2.05301603
101Supernumerary bones of the axial skeleton (HP:0009144)2.04710739
102Squamous cell carcinoma (HP:0002860)2.03718891
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03516611
104Short 5th finger (HP:0009237)2.02486838
105Poikiloderma (HP:0001029)1.97754906
106Pterygium (HP:0001059)1.96314987
107Dysautonomia (HP:0002459)1.96086903
108Poor suck (HP:0002033)1.95659834
109Patchy hypopigmentation of hair (HP:0011365)1.95033223
110Abnormality of the preputium (HP:0100587)1.93117044
111Vertebral clefting (HP:0008428)1.92946173
112Pallor (HP:0000980)1.92553046
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.91539812
114Abnormal sex determination (HP:0012244)1.90114822
115Sex reversal (HP:0012245)1.90114822
116Acute necrotizing encephalopathy (HP:0006965)1.89143062
117Muscle fiber atrophy (HP:0100295)1.89131047
118Congenital hip dislocation (HP:0001374)1.88874571
119Premature graying of hair (HP:0002216)1.87977593
120Chronic bronchitis (HP:0004469)1.87578750
121Broad distal phalanx of finger (HP:0009836)1.87348990
122Optic nerve hypoplasia (HP:0000609)1.86759820
123Hypotelorism (HP:0000601)1.86664967
124Abnormality of chromosome stability (HP:0003220)1.86625537
125Hypochromic anemia (HP:0001931)1.86091069
126Hamartoma (HP:0010566)1.85924672
127Premature ovarian failure (HP:0008209)1.85657862
128Abnormality of sulfur amino acid metabolism (HP:0004339)1.85556056
129Abnormality of the aortic arch (HP:0012303)1.82382411
130Tracheoesophageal fistula (HP:0002575)1.81278593
131Preaxial foot polydactyly (HP:0001841)1.81138229
132Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.81080087
133Aplasia/Hypoplasia of the sternum (HP:0006714)1.80839006
134Coronal craniosynostosis (HP:0004440)1.80445996
135Nasal speech (HP:0001611)1.80359499
136Short chin (HP:0000331)1.79857232
137Pseudobulbar signs (HP:0002200)1.79848648
138Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.79773459
139Absent eyebrow (HP:0002223)1.79650664
140Meckel diverticulum (HP:0002245)1.79564194
141Sensory axonal neuropathy (HP:0003390)1.79449644
142Alacrima (HP:0000522)1.79215678
143Anophthalmia (HP:0000528)1.78934797
144Deformed tarsal bones (HP:0008119)1.76940913
145Cleft eyelid (HP:0000625)1.75792821
146Preauricular skin tag (HP:0000384)1.75734118
147Atresia of the external auditory canal (HP:0000413)1.75590689
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75367361
149Small intestinal stenosis (HP:0012848)1.74959204
150Duodenal stenosis (HP:0100867)1.74959204
151Hepatoblastoma (HP:0002884)1.74849081
152Dysphonia (HP:0001618)1.74114095
153Hypotrichosis (HP:0001006)1.72861191
154Acute encephalopathy (HP:0006846)1.72556865
155Broad thumb (HP:0011304)1.72516897
156Hyperglycinemia (HP:0002154)1.71606272
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70654070
158Absent epiphyses (HP:0010577)1.70654070
159Cellular immunodeficiency (HP:0005374)1.69941525
160Colon cancer (HP:0003003)1.69478153
161Testicular atrophy (HP:0000029)1.69376128
162Cerebral aneurysm (HP:0004944)1.68954922
163Abnormality of the nasolacrimal system (HP:0000614)1.68547602
164Generalized hypotonia (HP:0001290)1.68169317
165Abnormality of cochlea (HP:0000375)1.66947680
166Abnormality of the duodenum (HP:0002246)1.66497482
167Thin ribs (HP:0000883)1.64314870
168Rocker bottom foot (HP:0001838)1.64193094
169High anterior hairline (HP:0009890)1.63947069
170Cerebral hypomyelination (HP:0006808)1.63616860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.05178737
2ICK4.47985387
3DDR23.51135420
4VRK23.46255273
5TYRO33.19700094
6MAPK153.02058498
7MATK2.78491641
8MKNK12.63422911
9EPHA22.60235006
10CDK72.56376549
11MAP3K62.47426109
12ZAK2.38649334
13PBK2.31132029
14NME22.29752281
15CDK192.28371975
16AKT32.27286541
17SMG12.27251481
18TAF12.14114585
19TSSK62.09303108
20PLK32.04695421
21TNIK2.01700259
22MAP3K111.97642076
23LATS21.92843192
24TTK1.91516306
25NME11.88309988
26GRK61.77766408
27BMX1.73096541
28FGR1.70803797
29WEE11.70274409
30CDC71.70188935
31BUB11.67728450
32PINK11.65230789
33VRK11.65014304
34UHMK11.64338354
35CHEK21.61221773
36PLK11.60633602
37PDGFRA1.57676456
38MAP3K101.54152846
39GRK51.51470456
40DYRK1B1.51181365
41CSK1.48809203
42STK161.46683133
43DAPK11.46526427
44DYRK31.46222014
45YES11.42025424
46RPS6KB21.41250896
47PLK41.41140935
48EEF2K1.40052911
49PRKD21.36628289
50NEK11.27282020
51PIM11.17203813
52ERBB41.16765816
53PASK1.15940133
54NEK21.15906384
55STK101.13513969
56CDK61.12645867
57PAK41.12300366
58KDR1.12159270
59MTOR1.09597221
60BRSK21.04603488
61ALK1.03448027
62CHEK11.00198552
63DMPK0.92413373
64MAP3K90.92218224
65PIM20.91022820
66BRSK10.89183713
67CDK20.89008050
68HIPK20.88385730
69AURKA0.87210730
70GSK3A0.86891602
71TRIM280.86875689
72ATR0.86687744
73NUAK10.86606387
74CDC42BPA0.85927174
75ERN10.84372938
76CAMK1D0.81567068
77STK30.78204087
78MST40.75946842
79AURKB0.75940942
80CAMK1G0.75639739
81TRIB30.75503171
82CDK40.73024948
83BRAF0.72412377
84RPS6KC10.70315596
85RPS6KL10.70315596
86MAPKAPK30.69964968
87ATM0.68262217
88FGFR10.68076445
89BRD40.66948324
90FGFR20.66193938
91CSNK1G10.65986308
92CDK30.65669890
93PRKCI0.65659335
94AKT20.63109144
95DYRK20.61464144
96GRK10.60288707
97RPS6KA50.59939610
98TLK10.59495842
99BCKDK0.59470075
100TESK20.59353073
101PRKDC0.58506865
102LATS10.56261865
103ADRBK20.54822632
104PNCK0.54793943
105PTK20.54366150
106MAP3K80.53827613
107MAPK70.52857878
108RPS6KA60.52616177
109PHKG20.52391239
110PHKG10.52391239
111WNK30.52350070
112RPS6KA10.52263458
113SRPK10.51965608
114CDK10.51881784
115MAPK110.51624466
116CSNK1E0.51512894
117STK38L0.49615432
118CSNK2A20.47945796
119MARK20.47071878
120CSF1R0.46966415
121CSNK2A10.45759586
122MAPK10.44977658
123PAK10.44688751
124CAMK40.43856118
125ILK0.43544807
126MAPK140.42833517
127NLK0.42776306
128MAPK100.41867291
129TAOK20.39830586
130PRKG20.39235935
131MET0.38827337
132FLT30.38179286
133PRPF4B0.36088544
134PRKAA10.35417151
135CSNK1G30.35203110
136GSK3B0.34914534
137CDK11A0.33746032
138DAPK30.33205380
139MOS0.33086312
140EIF2AK20.32095226
141STK380.30913126
142DYRK1A0.30895666
143CDK150.30513928
144MARK30.30451187
145NTRK10.29722019
146STK40.29424043
147CDK180.28953974
148RIPK10.28547073
149MKNK20.28537942
150CSNK1G20.25905438

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.78846511
2DNA replication_Homo sapiens_hsa030304.09586746
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.00518371
4Base excision repair_Homo sapiens_hsa034103.65489552
5RNA transport_Homo sapiens_hsa030133.03801874
6Spliceosome_Homo sapiens_hsa030402.98337563
7mRNA surveillance pathway_Homo sapiens_hsa030152.50370115
8Nucleotide excision repair_Homo sapiens_hsa034202.36974211
9Fatty acid biosynthesis_Homo sapiens_hsa000612.34769199
10Homologous recombination_Homo sapiens_hsa034402.26939428
11Fanconi anemia pathway_Homo sapiens_hsa034602.22605500
12One carbon pool by folate_Homo sapiens_hsa006702.20852306
13Cell cycle_Homo sapiens_hsa041102.06251244
14Ribosome_Homo sapiens_hsa030102.04086356
15Hippo signaling pathway_Homo sapiens_hsa043901.85316288
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84449790
17Hedgehog signaling pathway_Homo sapiens_hsa043401.75318894
18p53 signaling pathway_Homo sapiens_hsa041151.72392449
19Fructose and mannose metabolism_Homo sapiens_hsa000511.68572150
20Parkinsons disease_Homo sapiens_hsa050121.66174136
21RNA polymerase_Homo sapiens_hsa030201.65431744
22mTOR signaling pathway_Homo sapiens_hsa041501.64247766
23Notch signaling pathway_Homo sapiens_hsa043301.62477625
24Basal cell carcinoma_Homo sapiens_hsa052171.62181351
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.60473917
26Oxidative phosphorylation_Homo sapiens_hsa001901.54113389
27Huntingtons disease_Homo sapiens_hsa050161.49049831
28Biosynthesis of amino acids_Homo sapiens_hsa012301.48357351
29Pyruvate metabolism_Homo sapiens_hsa006201.44801153
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41451891
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40495240
32Adherens junction_Homo sapiens_hsa045201.38598523
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30931622
34Thyroid cancer_Homo sapiens_hsa052161.29201032
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29087930
36RNA degradation_Homo sapiens_hsa030181.26463794
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26082231
38Bladder cancer_Homo sapiens_hsa052191.25777527
39Purine metabolism_Homo sapiens_hsa002301.24840925
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22472703
41Vitamin B6 metabolism_Homo sapiens_hsa007501.21544162
42TGF-beta signaling pathway_Homo sapiens_hsa043501.21209614
43Sulfur relay system_Homo sapiens_hsa041221.17768502
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16672157
45MicroRNAs in cancer_Homo sapiens_hsa052061.16444199
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13527010
47Wnt signaling pathway_Homo sapiens_hsa043101.04087223
48Pyrimidine metabolism_Homo sapiens_hsa002401.00076605
49Arginine and proline metabolism_Homo sapiens_hsa003300.98590405
50Basal transcription factors_Homo sapiens_hsa030220.98360265
51Folate biosynthesis_Homo sapiens_hsa007900.97854933
52Galactose metabolism_Homo sapiens_hsa000520.96901223
53Oocyte meiosis_Homo sapiens_hsa041140.94670765
54Alzheimers disease_Homo sapiens_hsa050100.93275057
55Vitamin digestion and absorption_Homo sapiens_hsa049770.89536594
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89391174
57Tight junction_Homo sapiens_hsa045300.88780006
58Cardiac muscle contraction_Homo sapiens_hsa042600.87830050
59Lysine degradation_Homo sapiens_hsa003100.86197456
60Steroid biosynthesis_Homo sapiens_hsa001000.84695874
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.79976193
62Colorectal cancer_Homo sapiens_hsa052100.78719538
63Viral carcinogenesis_Homo sapiens_hsa052030.77343855
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73903327
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73172698
66Small cell lung cancer_Homo sapiens_hsa052220.72223265
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69970631
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69557111
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.68873897
70Proteasome_Homo sapiens_hsa030500.66588233
71Propanoate metabolism_Homo sapiens_hsa006400.66577369
72Protein export_Homo sapiens_hsa030600.66428632
73Pentose phosphate pathway_Homo sapiens_hsa000300.63553419
74Pathways in cancer_Homo sapiens_hsa052000.61995210
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.61910534
76Non-homologous end-joining_Homo sapiens_hsa034500.60927524
77Fatty acid elongation_Homo sapiens_hsa000620.60466713
78Acute myeloid leukemia_Homo sapiens_hsa052210.55152544
79VEGF signaling pathway_Homo sapiens_hsa043700.54960479
80Metabolic pathways_Homo sapiens_hsa011000.54104349
81Alcoholism_Homo sapiens_hsa050340.50568673
82Arachidonic acid metabolism_Homo sapiens_hsa005900.50385530
83Selenocompound metabolism_Homo sapiens_hsa004500.49730963
84Linoleic acid metabolism_Homo sapiens_hsa005910.48332058
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47820772
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46414118
87Epstein-Barr virus infection_Homo sapiens_hsa051690.46108879
88HTLV-I infection_Homo sapiens_hsa051660.45990998
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42266076
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42206682
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41799819
92Proteoglycans in cancer_Homo sapiens_hsa052050.41019818
93AMPK signaling pathway_Homo sapiens_hsa041520.40423109
94Herpes simplex infection_Homo sapiens_hsa051680.40222024
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39584090
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37848262
97Systemic lupus erythematosus_Homo sapiens_hsa053220.37816102
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37689389
99Dorso-ventral axis formation_Homo sapiens_hsa043200.37128064
100Circadian rhythm_Homo sapiens_hsa047100.37095270
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35392256
102Choline metabolism in cancer_Homo sapiens_hsa052310.34445254
103Endometrial cancer_Homo sapiens_hsa052130.34328689
104Glutathione metabolism_Homo sapiens_hsa004800.34261596
105Viral myocarditis_Homo sapiens_hsa054160.33638075
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32320837
107N-Glycan biosynthesis_Homo sapiens_hsa005100.31640178
108Melanoma_Homo sapiens_hsa052180.31098024
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30706277
110ErbB signaling pathway_Homo sapiens_hsa040120.30503708
111Chronic myeloid leukemia_Homo sapiens_hsa052200.30204900
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28498417
113Shigellosis_Homo sapiens_hsa051310.28457089
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28170696
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27961983
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26712600
117Focal adhesion_Homo sapiens_hsa045100.26612046
118Rap1 signaling pathway_Homo sapiens_hsa040150.25196982
119Carbon metabolism_Homo sapiens_hsa012000.24255928
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22800394
121Arginine biosynthesis_Homo sapiens_hsa002200.22405444
122Prostate cancer_Homo sapiens_hsa052150.22337057
123Gap junction_Homo sapiens_hsa045400.21959577
124HIF-1 signaling pathway_Homo sapiens_hsa040660.21554801
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19576048
126Tyrosine metabolism_Homo sapiens_hsa003500.17119684
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.16299761
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16297397
129Melanogenesis_Homo sapiens_hsa049160.15568031
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14709252
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13144991
132beta-Alanine metabolism_Homo sapiens_hsa004100.12519557
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.12382128

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