FOXD4L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOX DNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play a role in human cancer. This gene lies in a region of chromosome 2 that surrounds the site where two ancestral chromosomes fused to form human chromosome 2. This region is duplicated elsewhere in the human genome, primarily in subtelomeric and pericentromeric locations, thus mutiple copies of this gene have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)8.51962960
2negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)8.07280921
3DNA strand renaturation (GO:0000733)7.85749566
4GDP-mannose metabolic process (GO:0019673)7.69458185
5meiotic chromosome segregation (GO:0045132)7.46056104
6regulation of skeletal muscle contraction (GO:0014819)7.25319823
7folic acid metabolic process (GO:0046655)7.25017863
8adenosine receptor signaling pathway (GO:0001973)7.07692054
9negative regulation of cell aging (GO:0090344)6.79126428
10cell morphogenesis involved in neuron differentiation (GO:0048667)6.35560395
11purinergic nucleotide receptor signaling pathway (GO:0035590)5.96176427
12post-embryonic morphogenesis (GO:0009886)5.93444065
13lens fiber cell differentiation (GO:0070306)5.48660604
14mannose metabolic process (GO:0006013)5.30752312
15chaperone mediated protein folding requiring cofactor (GO:0051085)5.30197513
16peptidyl-glutamic acid carboxylation (GO:0017187)5.18061447
17protein carboxylation (GO:0018214)5.18061447
18G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.14219115
19response to pheromone (GO:0019236)5.06173194
20behavioral response to nicotine (GO:0035095)5.02522273
21positive regulation of heat generation (GO:0031652)5.02027631
22regulation of cytokine production involved in inflammatory response (GO:1900015)4.98371134
23very-low-density lipoprotein particle assembly (GO:0034379)4.94430414
24mitotic cell cycle arrest (GO:0071850)4.85828945
25adenine nucleotide transport (GO:0051503)4.78482218
26regulation of synapse structural plasticity (GO:0051823)4.75596347
27positive regulation of protein kinase C signaling (GO:0090037)4.74293149
28purinergic receptor signaling pathway (GO:0035587)4.69985809
29response to ATP (GO:0033198)4.61556317
30sensory perception of taste (GO:0050909)4.57313955
31mitochondrial genome maintenance (GO:0000002)4.51346057
32estrogen biosynthetic process (GO:0006703)4.36932786
33purine ribonucleotide transport (GO:0015868)4.35703313
34rRNA methylation (GO:0031167)4.32715332
35intestinal cholesterol absorption (GO:0030299)4.15963508
36mitochondrial DNA replication (GO:0006264)4.11821550
37folic acid-containing compound biosynthetic process (GO:0009396)4.11750108
38regulation of gene silencing by RNA (GO:0060966)4.09612885
39regulation of posttranscriptional gene silencing (GO:0060147)4.09612885
40regulation of gene silencing by miRNA (GO:0060964)4.09612885
41detection of light stimulus involved in sensory perception (GO:0050962)4.06744905
42detection of light stimulus involved in visual perception (GO:0050908)4.06744905
43proline biosynthetic process (GO:0006561)4.06074826
44mitochondrial DNA metabolic process (GO:0032042)4.04919258
45nucleoside transmembrane transport (GO:1901642)4.04042321
46oogenesis (GO:0048477)4.02824188
47female gamete generation (GO:0007292)4.01284610
48rRNA modification (GO:0000154)4.00603609
49positive regulation of CREB transcription factor activity (GO:0032793)4.00331452
50folic acid transport (GO:0015884)3.89419440
51synapsis (GO:0007129)3.84840394
52nucleotide-sugar biosynthetic process (GO:0009226)3.82600488
53regulation of heat generation (GO:0031650)3.80732773
54regulation of translational fidelity (GO:0006450)3.79976785
55transepithelial transport (GO:0070633)3.70410545
56UV protection (GO:0009650)3.69543160
57negative regulation of interleukin-8 production (GO:0032717)3.67334754
58granulocyte differentiation (GO:0030851)3.66788833
59sphingosine metabolic process (GO:0006670)3.59354575
60G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.55667180
61purine nucleotide transport (GO:0015865)3.53879955
62regulation of protein kinase A signaling (GO:0010738)3.52946964
63peristalsis (GO:0030432)3.44684945
64base-excision repair, AP site formation (GO:0006285)3.42202113
65urinary tract smooth muscle contraction (GO:0014848)3.41957931
66regulation of phospholipid biosynthetic process (GO:0071071)3.41716370
67histone phosphorylation (GO:0016572)3.36594730
68phosphatidylethanolamine biosynthetic process (GO:0006646)3.34809270
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.34768651
70neuromuscular synaptic transmission (GO:0007274)3.32035550
71mitochondrion distribution (GO:0048311)3.29144209
72folic acid-containing compound metabolic process (GO:0006760)3.20546714
73sex determination (GO:0007530)3.20233963
74nucleotide transmembrane transport (GO:1901679)3.19382911
75regulation of cell aging (GO:0090342)3.18765502
76synaptic transmission, cholinergic (GO:0007271)3.17130580
77diol metabolic process (GO:0034311)3.14619302
78negative regulation of gene silencing (GO:0060969)3.14268844
79male meiosis I (GO:0007141)3.14142879
80histone H3-K9 modification (GO:0061647)3.03220096
81long term synaptic depression (GO:0060292)3.03192185
82pseudouridine synthesis (GO:0001522)2.99936182
83melanin biosynthetic process (GO:0042438)2.98241455
84negative regulation of toll-like receptor signaling pathway (GO:0034122)2.98135266
85proline metabolic process (GO:0006560)2.96661191
86peptidyl-lysine dimethylation (GO:0018027)2.96351234
87nucleoside transport (GO:0015858)2.96003746
88phosphatidylethanolamine metabolic process (GO:0046337)2.95982392
89protein insertion into membrane (GO:0051205)2.95178639
90regulation of meiosis (GO:0040020)2.93634648
91ovarian follicle development (GO:0001541)2.89603597
92L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89542229
93negative regulation of tumor necrosis factor production (GO:0032720)2.89165906
94positive thymic T cell selection (GO:0045059)2.85576981
95DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.82359164
96muscle fiber development (GO:0048747)2.79499030
97cellular anion homeostasis (GO:0030002)2.78635506
98grooming behavior (GO:0007625)2.78504819
99negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.78140917
100trivalent inorganic anion homeostasis (GO:0072506)2.77571121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.23745566
2CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.28425052
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.16785821
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.16315595
5P68_20966046_ChIP-Seq_HELA_Human2.95809241
6LXR_22292898_ChIP-Seq_THP-1_Human2.85635893
7E2F1_20622854_ChIP-Seq_HELA_Human2.58609585
8XRN2_22483619_ChIP-Seq_HELA_Human2.58136959
9DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.48056872
10MAF_26560356_Chip-Seq_TH2_Human2.45591213
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42438043
12MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.29684092
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.29167987
14BCL6_27268052_Chip-Seq_Bcells_Human2.28346022
15BCOR_27268052_Chip-Seq_Bcells_Human2.27462302
16VDR_24763502_ChIP-Seq_THP-1_Human2.14945767
17PHF8_20622854_ChIP-Seq_HELA_Human2.09582375
18RACK7_27058665_Chip-Seq_MCF-7_Human2.07866101
19TET1_21451524_ChIP-Seq_MESCs_Mouse1.97625539
20SMC4_20622854_ChIP-Seq_HELA_Human1.96878347
21MYC_22102868_ChIP-Seq_BL_Human1.95670370
22CTCF_27219007_Chip-Seq_Bcells_Human1.94439584
23CTCF_27219007_Chip-Seq_ERYTHROID_Human1.90863872
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.86987100
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.85638232
26MAF_26560356_Chip-Seq_TH1_Human1.81441800
27RARB_24833708_ChIP-Seq_LIVER_Mouse1.80549384
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78086364
29CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.77981964
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76747270
31SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.74433813
32SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71951024
33FOXP1_21924763_ChIP-Seq_HESCs_Human1.71737142
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71449248
35DCP1A_22483619_ChIP-Seq_HELA_Human1.70512536
36RARA_24833708_ChIP-Seq_LIVER_Mouse1.70311482
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69609883
38CTCF_21964334_Chip-Seq_Bcells_Human1.67870594
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.67205350
40RXRA_24833708_ChIP-Seq_LIVER_Mouse1.65046989
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64191793
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.63185519
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57287554
44SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55392692
45CTCF_21964334_ChIP-Seq_BJAB-B_Human1.49782115
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48911429
47UTX_26944678_Chip-Seq_JUKART_Human1.47846507
48FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47651118
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47395255
50TP53_22127205_ChIP-Seq_IMR90_Human1.47272179
51JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.46563946
52CIITA_25753668_ChIP-Seq_RAJI_Human1.45891328
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45282277
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44297231
55CREB1_26743006_Chip-Seq_LNCaP_Human1.43629157
56CTCF_20526341_ChIP-Seq_ESCs_Human1.42463068
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.41710983
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41557508
59RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39784971
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.38463100
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37117727
62ETS1_21867929_ChIP-Seq_TH2_Mouse1.36609589
63ERA_21632823_ChIP-Seq_H3396_Human1.35387524
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33576632
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29457136
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28768032
67KDM2B_26808549_Chip-Seq_DND41_Human1.28684144
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27920468
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.27881818
70CTCF_26484167_Chip-Seq_Bcells_Mouse1.27265084
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27051381
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23999759
73E2F7_22180533_ChIP-Seq_HELA_Human1.23730399
74SA1_27219007_Chip-Seq_Bcells_Human1.23375472
75OCT4_20526341_ChIP-Seq_ESCs_Human1.21121539
76GABP_19822575_ChIP-Seq_HepG2_Human1.20586301
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19710490
78SPI1_26923725_Chip-Seq_HPCs_Mouse1.19164331
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.18148368
80TCF7_22412390_ChIP-Seq_EML_Mouse1.17992500
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17345271
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16709485
83P300_27268052_Chip-Seq_Bcells_Human1.15864292
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11187973
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10939693
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10528875
87OCT4_19829295_ChIP-Seq_ESCs_Human1.10006166
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09888955
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.06897213
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06761485
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06486425
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06311873
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.04616730
94ATF3_27146783_Chip-Seq_COLON_Human1.03627795
95MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03460268
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.03215622
97P53_21459846_ChIP-Seq_SAOS-2_Human1.02179383
98RAC3_21632823_ChIP-Seq_H3396_Human1.01053186
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00821807
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00198241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.95107948
2MP0005171_absent_coat_pigmentation6.53997975
3MP0003136_yellow_coat_color5.70109420
4MP0005174_abnormal_tail_pigmentation5.39722133
5MP0005423_abnormal_somatic_nervous4.56064033
6MP0005409_darkened_coat_color2.89812344
7MP0001188_hyperpigmentation2.67466248
8MP0005083_abnormal_biliary_tract2.57542730
9MP0001968_abnormal_touch/_nociception2.49262981
10MP0003453_abnormal_keratinocyte_physiol2.24269579
11MP0000015_abnormal_ear_pigmentation2.18024687
12MP0008875_abnormal_xenobiotic_pharmacok2.08721913
13MP0003806_abnormal_nucleotide_metabolis2.07221237
14MP0000751_myopathy2.01940824
15MP0002638_abnormal_pupillary_reflex1.93314955
16MP0003172_abnormal_lysosome_physiology1.93285848
17MP0005257_abnormal_intraocular_pressure1.92194202
18MP0001661_extended_life_span1.87796924
19MP0002736_abnormal_nociception_after1.84505995
20MP0002160_abnormal_reproductive_system1.83925778
21MP0003111_abnormal_nucleus_morphology1.82366526
22MP0004381_abnormal_hair_follicle1.78187034
23MP0004043_abnormal_pH_regulation1.72468109
24MP0001756_abnormal_urination1.69026980
25MP0006072_abnormal_retinal_apoptosis1.62466840
26MP0000750_abnormal_muscle_regeneration1.62212240
27MP0005330_cardiomyopathy1.61677465
28MP0005076_abnormal_cell_differentiation1.54931192
29MP0010094_abnormal_chromosome_stability1.54791688
30MP0003646_muscle_fatigue1.49496801
31MP0005253_abnormal_eye_physiology1.44274832
32MP0000538_abnormal_urinary_bladder1.40204926
33MP0003656_abnormal_erythrocyte_physiolo1.35112081
34MP0003077_abnormal_cell_cycle1.33724489
35MP0003011_delayed_dark_adaptation1.30515734
36MP0003693_abnormal_embryo_hatching1.27360621
37MP0005551_abnormal_eye_electrophysiolog1.26221340
38MP0003303_peritoneal_inflammation1.20533119
39MP0002332_abnormal_exercise_endurance1.17378909
40MP0002735_abnormal_chemical_nociception1.17134176
41MP0001502_abnormal_circadian_rhythm1.16682489
42MP0005501_abnormal_skin_physiology1.14658962
43MP0004130_abnormal_muscle_cell1.11822450
44MP0005365_abnormal_bile_salt1.08638528
45MP0004957_abnormal_blastocyst_morpholog1.06847342
46MP0001919_abnormal_reproductive_system1.03382303
47MP0003705_abnormal_hypodermis_morpholog1.01118776
48MP0002095_abnormal_skin_pigmentation1.00623872
49MP0000747_muscle_weakness1.00078627
50MP0002210_abnormal_sex_determination0.99894605
51MP0005332_abnormal_amino_acid0.97725125
52MP0005389_reproductive_system_phenotype0.89682091
53MP0005058_abnormal_lysosome_morphology0.84713023
54MP0005410_abnormal_fertilization0.84665913
55MP0010386_abnormal_urinary_bladder0.84408350
56MP0005387_immune_system_phenotype0.84170142
57MP0001790_abnormal_immune_system0.84170142
58MP0003448_altered_tumor_morphology0.84088111
59MP0010771_integument_phenotype0.82140640
60MP0001664_abnormal_digestion0.80759522
61MP0001873_stomach_inflammation0.80207900
62MP0000749_muscle_degeneration0.79614422
63MP0002019_abnormal_tumor_incidence0.78897781
64MP0002254_reproductive_system_inflammat0.78173398
65MP0005584_abnormal_enzyme/coenzyme_acti0.77184552
66MP0002075_abnormal_coat/hair_pigmentati0.76925892
67MP0005391_vision/eye_phenotype0.73790964
68MP0008995_early_reproductive_senescence0.71094693
69MP0001765_abnormal_ion_homeostasis0.70587593
70MP0000858_altered_metastatic_potential0.69676039
71MP0000685_abnormal_immune_system0.69123269
72MP0009931_abnormal_skin_appearance0.66869180
73MP0002876_abnormal_thyroid_physiology0.66548392
74MP0001324_abnormal_eye_pigmentation0.65456115
75MP0008007_abnormal_cellular_replicative0.62156331
76MP0000470_abnormal_stomach_morphology0.59697930
77MP0006036_abnormal_mitochondrial_physio0.57992473
78MP0000367_abnormal_coat/_hair0.57904668
79MP0004197_abnormal_fetal_growth/weight/0.57854217
80MP0001929_abnormal_gametogenesis0.57168036
81MP0000371_diluted_coat_color0.57120546
82MP0002060_abnormal_skin_morphology0.56412020
83MP0001145_abnormal_male_reproductive0.56330069
84MP0004147_increased_porphyrin_level0.55442619
85MP0000733_abnormal_muscle_development0.55275476
86MP0000427_abnormal_hair_cycle0.54040231
87MP0001348_abnormal_lacrimal_gland0.53632844
88MP0003091_abnormal_cell_migration0.52885569
89MP0000759_abnormal_skeletal_muscle0.52807690
90MP0001970_abnormal_pain_threshold0.51357260
91MP0000013_abnormal_adipose_tissue0.49772312
92MP0004233_abnormal_muscle_weight0.47842370
93MP0008770_decreased_survivor_rate0.47488758
94MP0004087_abnormal_muscle_fiber0.46337734
95MP0000358_abnormal_cell_content/0.44932065
96MP0003878_abnormal_ear_physiology0.43795465
97MP0005377_hearing/vestibular/ear_phenot0.43795465
98MP0001186_pigmentation_phenotype0.43366570
99MP0000653_abnormal_sex_gland0.42870752
100MP0001191_abnormal_skin_condition0.42325924

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.76268483
2Testicular atrophy (HP:0000029)6.66969197
3Popliteal pterygium (HP:0009756)5.84589309
4Rib fusion (HP:0000902)5.44242407
5Akinesia (HP:0002304)5.37770822
6Annular pancreas (HP:0001734)5.08586410
7Progressive external ophthalmoplegia (HP:0000590)4.99305435
8Fetal akinesia sequence (HP:0001989)4.76626410
9Abnormality of placental membranes (HP:0011409)4.61760055
10Amniotic constriction ring (HP:0009775)4.61760055
11Aplasia of the musculature (HP:0100854)4.59329622
12Dyschromatopsia (HP:0007641)4.47073421
13Facial hemangioma (HP:0000329)4.40950841
14Thin bony cortex (HP:0002753)4.40544152
15Rectovaginal fistula (HP:0000143)4.40397352
16Rectal fistula (HP:0100590)4.40397352
17Abnormality of the intrinsic pathway (HP:0010989)4.27089658
18Coronal craniosynostosis (HP:0004440)4.26615550
19Poikiloderma (HP:0001029)4.24461684
20Intestinal fistula (HP:0100819)4.21063397
21Vaginal fistula (HP:0004320)3.92898085
22Attenuation of retinal blood vessels (HP:0007843)3.91387597
23Type 2 muscle fiber atrophy (HP:0003554)3.69395045
24Ulnar bowing (HP:0003031)3.66244766
25Prolonged partial thromboplastin time (HP:0003645)3.65722937
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.58290515
27Facial diplegia (HP:0001349)3.55385902
28Muscle fiber atrophy (HP:0100295)3.42949488
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.40833605
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.32582150
31Short chin (HP:0000331)3.28022702
32Squamous cell carcinoma (HP:0002860)3.18352192
33Bony spicule pigmentary retinopathy (HP:0007737)3.11570471
34Hemorrhage of the eye (HP:0011885)3.05358222
35Delayed epiphyseal ossification (HP:0002663)3.04787945
36Agammaglobulinemia (HP:0004432)3.00489695
37Diminished movement (HP:0002374)2.90287738
38Aplasia/Hypoplasia involving the musculature (HP:0001460)2.88811789
39Malignant hyperthermia (HP:0002047)2.87355857
40Patellar aplasia (HP:0006443)2.85157332
41Mesangial abnormality (HP:0001966)2.80963636
42Turricephaly (HP:0000262)2.80218043
43Joint hemorrhage (HP:0005261)2.79977943
44Enlarged epiphyses (HP:0010580)2.79369030
45Chorioretinal atrophy (HP:0000533)2.75616251
46Aplasia/Hypoplasia of the patella (HP:0006498)2.74310180
47Thin ribs (HP:0000883)2.70207286
48External ophthalmoplegia (HP:0000544)2.65874595
49Easy fatigability (HP:0003388)2.65723905
50Persistence of primary teeth (HP:0006335)2.64775363
51Premature graying of hair (HP:0002216)2.64438594
52Fatigable weakness (HP:0003473)2.61308774
53Abnormality of the neuromuscular junction (HP:0003398)2.61308774
54Abnormal albumin level (HP:0012116)2.57619084
55Hypoalbuminemia (HP:0003073)2.57619084
56Anteriorly placed anus (HP:0001545)2.57264564
57Abnormality of the costochondral junction (HP:0000919)2.54096210
58Myotonia (HP:0002486)2.50506432
59Capillary hemangiomas (HP:0005306)2.46756827
60Hypophosphatemic rickets (HP:0004912)2.42599544
61Reduced antithrombin III activity (HP:0001976)2.42387151
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40910992
63Choroideremia (HP:0001139)2.39013668
64Absent thumb (HP:0009777)2.36607820
65Pterygium (HP:0001059)2.32183130
66Cystic hygroma (HP:0000476)2.31972467
67Decreased central vision (HP:0007663)2.30506386
68Progressive muscle weakness (HP:0003323)2.28290587
69Increased intramyocellular lipid droplets (HP:0012240)2.20269767
70Increased number of teeth (HP:0011069)2.18450768
71Mask-like facies (HP:0000298)2.17159841
72Absent radius (HP:0003974)2.15650149
73Protruding tongue (HP:0010808)2.14687273
74Hypoplasia of the pons (HP:0012110)2.06843540
75Birth length less than 3rd percentile (HP:0003561)2.05758222
76Abnormal trabecular bone morphology (HP:0100671)2.04318511
77Flat occiput (HP:0005469)2.01993992
78Atrioventricular block (HP:0001678)2.01385655
79Absent forearm bone (HP:0003953)2.00069181
80Aplasia involving forearm bones (HP:0009822)2.00069181
81Dysphonia (HP:0001618)2.00004499
82Increased muscle lipid content (HP:0009058)1.99893727
83Myopathic facies (HP:0002058)1.99154570
84Weak cry (HP:0001612)1.97141409
85Bowed forearm bones (HP:0003956)1.95618623
86Bowing of the arm (HP:0006488)1.95618623
87Widely patent fontanelles and sutures (HP:0004492)1.89809657
88Bulbar palsy (HP:0001283)1.88876654
89Chronic sinusitis (HP:0011109)1.87851742
90Microvesicular hepatic steatosis (HP:0001414)1.86340370
91Rectal prolapse (HP:0002035)1.85989055
92Joint stiffness (HP:0001387)1.84287854
93Short humerus (HP:0005792)1.83123119
94Abnormality of the pons (HP:0007361)1.80053568
95Neonatal onset (HP:0003623)1.79971404
96Basal cell carcinoma (HP:0002671)1.77502054
97Type I transferrin isoform profile (HP:0003642)1.76938171
98Renal Fanconi syndrome (HP:0001994)1.76022102
99Aplasia/hypoplasia of the humerus (HP:0006507)1.74166155
100Short thumb (HP:0009778)1.71115693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.47677286
2GRK13.91795885
3WNK42.92564821
4SIK32.68492314
5SIK22.50502792
6SIK12.34406830
7MAP3K132.15454195
8TESK212.8587518
9ICK1.95954893
10ZAK1.71080439
11ARAF1.58002220
12CCNB11.57029760
13EIF2AK11.53881076
14ACVR1B1.49266107
15MAPKAPK31.43293827
16BLK1.42826982
17MUSK1.38184030
18STK161.28725226
19MAP3K91.08690072
20MST1R1.03595293
21MET0.98730114
22IRAK20.95215479
23MOS0.95213494
24TLK10.89360920
25BMX0.81858521
26IRAK30.75595297
27TRIB30.70728220
28GRK60.70565169
29PRKD30.69629707
30PDPK10.69383959
31BRAF0.68282608
32MAP3K110.68066073
33SRPK10.65796943
34CDK60.65085243
35WNK10.60764629
36MARK30.59164557
37CDK11A0.54947100
38MAPK110.54079846
39CDK150.54071913
40CDK40.51105286
41CDK180.50668486
42PIM20.48951529
43MAP2K30.47452563
44MARK20.43456852
45DAPK10.41924537
46PKN20.40745827
47CDK70.40594136
48ADRBK10.39740570
49KSR20.33862808
50PLK10.33314303
51PRKD20.31373357
52STK390.31015281
53CAMK1G0.31013492
54CDK140.30860400
55RAF10.29797227
56SYK0.29264865
57PRKAA10.28710394
58TBK10.28279565
59PRKCI0.28139784
60CHEK20.28094795
61TAOK20.28055395
62ATR0.27027675
63ERN10.26495452
64ZAP700.26044203
65MAP3K140.25838702
66AURKA0.25483639
67MAP3K80.24315096
68PRKD10.23813308
69DYRK1B0.23481208
70ADRBK20.23288449
71CASK0.22101090
72RPS6KA50.19880306
73CAMK1D0.18544968
74MTOR0.18101186
75EIF2AK30.17168450
76TRPM70.16783835
77EPHA20.15167965
78CAMK2B0.15002422
79AKT30.14628759
80MAPK120.13647704
81MAP3K10.13620649
82MAP2K10.13426478
83PRKACG0.12212602
84LYN0.11926195
85PNCK0.11842297
86CDK10.11431053
87TAF10.11036944
88TRIM280.10277346
89CSF1R0.10076745
90EEF2K0.09509547
91RPS6KA60.08843610
92CAMK2G0.08779967
93TYK20.08537486
94IRAK40.08505960
95CSNK1D0.07499271
96MAP2K60.06642287
97RPS6KC10.05550212
98RPS6KL10.05550212
99RPS6KA20.05168654
100PDGFRB0.04705791

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006046.80396086
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001305.55839583
3Sulfur relay system_Homo sapiens_hsa041225.45175586
4Phototransduction_Homo sapiens_hsa047443.57533843
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.09676412
6Fructose and mannose metabolism_Homo sapiens_hsa000512.98143207
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14000671
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03280259
9Fanconi anemia pathway_Homo sapiens_hsa034601.90742756
10Sphingolipid metabolism_Homo sapiens_hsa006001.89647005
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.88696015
12One carbon pool by folate_Homo sapiens_hsa006701.88417719
13Hedgehog signaling pathway_Homo sapiens_hsa043401.86335350
14Steroid biosynthesis_Homo sapiens_hsa001001.82926131
15Other glycan degradation_Homo sapiens_hsa005111.82692202
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.75774090
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.74932493
18Taste transduction_Homo sapiens_hsa047421.73562518
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59278144
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45346484
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37159693
22Circadian rhythm_Homo sapiens_hsa047101.33489465
23Pyruvate metabolism_Homo sapiens_hsa006201.28048574
24Base excision repair_Homo sapiens_hsa034101.21480969
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07084084
26Homologous recombination_Homo sapiens_hsa034401.03200315
27Lysine degradation_Homo sapiens_hsa003101.01533154
28Ovarian steroidogenesis_Homo sapiens_hsa049130.99552985
29Lysosome_Homo sapiens_hsa041420.96111281
30Primary immunodeficiency_Homo sapiens_hsa053400.94093061
31Nicotine addiction_Homo sapiens_hsa050330.93945536
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86791687
33VEGF signaling pathway_Homo sapiens_hsa043700.86279029
34Basal transcription factors_Homo sapiens_hsa030220.83075839
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80397316
36Pyrimidine metabolism_Homo sapiens_hsa002400.79143610
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77678965
38Intestinal immune network for IgA production_Homo sapiens_hsa046720.76670478
39Bladder cancer_Homo sapiens_hsa052190.72390740
40Calcium signaling pathway_Homo sapiens_hsa040200.71009756
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69921177
42Vitamin digestion and absorption_Homo sapiens_hsa049770.69480956
43Inositol phosphate metabolism_Homo sapiens_hsa005620.69332671
44B cell receptor signaling pathway_Homo sapiens_hsa046620.69179976
45RNA polymerase_Homo sapiens_hsa030200.68485491
46mTOR signaling pathway_Homo sapiens_hsa041500.67849801
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66004558
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65824305
49Cell cycle_Homo sapiens_hsa041100.62669556
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62370730
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.61809815
52Hepatitis C_Homo sapiens_hsa051600.60246734
53Hematopoietic cell lineage_Homo sapiens_hsa046400.56795988
54Alcoholism_Homo sapiens_hsa050340.55508939
55Influenza A_Homo sapiens_hsa051640.53153168
56Endocytosis_Homo sapiens_hsa041440.50811427
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50474392
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45567062
59Systemic lupus erythematosus_Homo sapiens_hsa053220.41828031
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38087704
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.35780405
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34134408
63Purine metabolism_Homo sapiens_hsa002300.33071240
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.32246233
65ABC transporters_Homo sapiens_hsa020100.31755904
66Hippo signaling pathway_Homo sapiens_hsa043900.31355053
67N-Glycan biosynthesis_Homo sapiens_hsa005100.31254419
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31006435
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.29968599
70Cocaine addiction_Homo sapiens_hsa050300.29260438
71Metabolic pathways_Homo sapiens_hsa011000.28400354
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25734307
73mRNA surveillance pathway_Homo sapiens_hsa030150.25524689
74p53 signaling pathway_Homo sapiens_hsa041150.24793220
75African trypanosomiasis_Homo sapiens_hsa051430.24260699
76HTLV-I infection_Homo sapiens_hsa051660.24142508
77Herpes simplex infection_Homo sapiens_hsa051680.23777776
78RNA transport_Homo sapiens_hsa030130.22068132
79Biosynthesis of amino acids_Homo sapiens_hsa012300.21684519
80Tuberculosis_Homo sapiens_hsa051520.20507762
81Sulfur metabolism_Homo sapiens_hsa009200.20506641
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.20405512
83Nucleotide excision repair_Homo sapiens_hsa034200.20364268
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19088153
85Insulin resistance_Homo sapiens_hsa049310.18657920
86Chemokine signaling pathway_Homo sapiens_hsa040620.18029355
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.17738705
88Gap junction_Homo sapiens_hsa045400.17040668
89TNF signaling pathway_Homo sapiens_hsa046680.15599340
90MAPK signaling pathway_Homo sapiens_hsa040100.15569169
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14272667
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14061953
93PPAR signaling pathway_Homo sapiens_hsa033200.13549840
94RNA degradation_Homo sapiens_hsa030180.13187085
95Chronic myeloid leukemia_Homo sapiens_hsa052200.13014381
96Melanogenesis_Homo sapiens_hsa049160.12316204
97Legionellosis_Homo sapiens_hsa051340.12094938
98Fatty acid biosynthesis_Homo sapiens_hsa000610.11326032
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.10364543
100Small cell lung cancer_Homo sapiens_hsa052220.09933105

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