FOXE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to lead ion (GO:0010288)8.98185376
2sulfate transmembrane transport (GO:1902358)8.80317556
3regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)8.56649719
4* thyroid gland development (GO:0030878)7.93461886
5regulation of apoptotic process involved in morphogenesis (GO:1902337)7.78055922
6regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033397.64081083
7sulfate transport (GO:0008272)7.50770428
8nephron tubule formation (GO:0072079)6.96319446
9pattern specification involved in kidney development (GO:0061004)6.93207201
10positive regulation of glycogen biosynthetic process (GO:0045725)6.77014437
11positive regulation of hormone metabolic process (GO:0032352)6.76777798
12phosphorelay signal transduction system (GO:0000160)6.73596652
13negative regulation of metanephros development (GO:0072217)6.59074479
14hydrogen peroxide catabolic process (GO:0042744)6.48940084
15positive regulation of glycogen metabolic process (GO:0070875)5.76249855
16negative regulation of microtubule polymerization (GO:0031115)5.76201630
17bicarbonate transport (GO:0015701)5.75604288
18hormone biosynthetic process (GO:0042446)5.65047326
19urogenital system development (GO:0001655)5.55172252
20metanephric nephron tubule development (GO:0072234)5.42868041
21metanephric tubule development (GO:0072170)5.42868041
22regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.34743369
23mesonephros development (GO:0001823)5.11220226
24* phenol-containing compound metabolic process (GO:0018958)5.03691607
25metanephric nephron epithelium development (GO:0072243)4.99422544
26positive regulation of cellular amine metabolic process (GO:0033240)4.98862169
27bone resorption (GO:0045453)4.91172735
28regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.71308716
29female gonad development (GO:0008585)4.67436780
30metanephric epithelium development (GO:0072207)4.54821764
31regulation of mesenchymal cell apoptotic process (GO:2001053)4.53486705
32response to vitamin D (GO:0033280)4.50746957
33regulation of hormone metabolic process (GO:0032350)4.45985511
34positive regulation of extracellular matrix organization (GO:1903055)4.40283450
35negative regulation of kidney development (GO:0090185)4.40275112
36regulation of myelination (GO:0031641)4.35373057
37regulation of stem cell maintenance (GO:2000036)4.35147250
38embryonic hemopoiesis (GO:0035162)4.24537058
39hemidesmosome assembly (GO:0031581)4.19007589
40positive regulation of metanephros development (GO:0072216)4.18493186
41* thyroid hormone generation (GO:0006590)33.2077471
42molting cycle (GO:0042303)3.92854636
43hair cycle (GO:0042633)3.92854636
44negative regulation of hormone metabolic process (GO:0032351)3.92732760
45negative regulation of hormone biosynthetic process (GO:0032353)3.92732760
46sulfur compound transport (GO:0072348)3.83641603
47negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.79530877
48regulation of water loss via skin (GO:0033561)3.71422922
49positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.69856578
50regulation of extracellular matrix disassembly (GO:0010715)3.68324777
51hydrogen peroxide metabolic process (GO:0042743)3.62651321
52G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.57154496
53specification of organ identity (GO:0010092)3.54939845
54regulation of glucocorticoid metabolic process (GO:0031943)3.54725423
55positive regulation of glucose import (GO:0046326)3.48623866
56regulation of glycogen biosynthetic process (GO:0005979)3.46123625
57regulation of glucan biosynthetic process (GO:0010962)3.46123625
58desmosome organization (GO:0002934)3.45456490
59sodium ion export (GO:0071436)3.42926385
60response to cadmium ion (GO:0046686)3.41942892
61positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.36816440
62phosphatidylinositol dephosphorylation (GO:0046856)3.31912646
63regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.28704473
64mitochondrion distribution (GO:0048311)3.27894465
65Golgi transport vesicle coating (GO:0048200)3.26765242
66COPI coating of Golgi vesicle (GO:0048205)3.26765242
67cellular response to gonadotropin stimulus (GO:0071371)3.23260436
68negative regulation of epithelial to mesenchymal transition (GO:0010719)3.20472962
69lung secretory cell differentiation (GO:0061140)3.14485793
70iron ion import (GO:0097286)3.13902328
71phospholipid dephosphorylation (GO:0046839)3.12714874
72cerebral cortex neuron differentiation (GO:0021895)3.12585424
73nephron tubule development (GO:0072080)3.12032250
74negative regulation of fatty acid transport (GO:2000192)3.10659348
75forebrain neuron differentiation (GO:0021879)3.10335572
76positive regulation of glucose metabolic process (GO:0010907)3.08384104
77surfactant homeostasis (GO:0043129)3.08047409
78positive regulation of mesonephros development (GO:0061213)3.06926799
79cellular potassium ion homeostasis (GO:0030007)3.04177134
80* thyroid hormone metabolic process (GO:0042403)26.4092654
81membrane repolarization during action potential (GO:0086011)2.99829519
82keratan sulfate catabolic process (GO:0042340)2.95245843
83establishment of skin barrier (GO:0061436)2.92874880
84epithelial cell morphogenesis (GO:0003382)2.91812946
85regulation of plasminogen activation (GO:0010755)2.90621211
86endothelial cell chemotaxis (GO:0035767)2.90512164
87maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90141887
88renal tubule development (GO:0061326)2.87787250
89Leydig cell differentiation (GO:0033327)2.85537557
90regulation of mesonephros development (GO:0061217)2.80781712
91regulation of polysaccharide biosynthetic process (GO:0032885)2.80269917
92regulation of extracellular matrix organization (GO:1903053)2.79155049
93skin morphogenesis (GO:0043589)2.79025272
94positive regulation of glucose transport (GO:0010828)2.77677962
95regulation of mitotic spindle organization (GO:0060236)2.75902718
96regulation of glycogen metabolic process (GO:0070873)2.74588530
97arachidonic acid secretion (GO:0050482)2.74387982
98icosanoid secretion (GO:0032309)2.74387982
99Rho protein signal transduction (GO:0007266)2.72345653
100epithelial tube branching involved in lung morphogenesis (GO:0060441)2.72272374
101protein retention in ER lumen (GO:0006621)2.71255794
102regulation of Rap GTPase activity (GO:0032317)2.70244788
103* cellular modified amino acid metabolic process (GO:0006575)2.67165850
104regulation of metanephros development (GO:0072215)2.66689395
105lung-associated mesenchyme development (GO:0060484)2.61390977
106negative regulation of macroautophagy (GO:0016242)2.61165182
107nephron epithelium development (GO:0072009)2.59227213
108mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.57957725
109multicellular organismal water homeostasis (GO:0050891)2.57949045
110NADH metabolic process (GO:0006734)2.57334112
111icosanoid transport (GO:0071715)2.54591452
112fatty acid derivative transport (GO:1901571)2.54591452
113mesenchymal to epithelial transition (GO:0060231)2.52775777
114* hormone metabolic process (GO:0042445)2.52768289
115positive regulation of bone mineralization (GO:0030501)2.51480477
116endothelial cell morphogenesis (GO:0001886)2.51275289
117protein maturation by protein folding (GO:0022417)2.50994785
118epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49563652
119ventricular cardiac muscle cell action potential (GO:0086005)2.47544216
120regulation of spindle organization (GO:0090224)2.47312822
121regulation of transforming growth factor beta2 production (GO:0032909)2.43466382
122coronary vasculature morphogenesis (GO:0060977)2.42591628
123intestinal epithelial cell development (GO:0060576)2.40607411
124cell adhesion mediated by integrin (GO:0033627)2.39687786
125regulation of glucose import in response to insulin stimulus (GO:2001273)2.39075111
126bundle of His cell to Purkinje myocyte communication (GO:0086069)2.38870268
127response to gonadotropin (GO:0034698)2.38749873
128regulation of hormone biosynthetic process (GO:0046885)2.37959465
129peptide catabolic process (GO:0043171)2.37941834
130sodium ion homeostasis (GO:0055078)2.37013642
131vitamin transmembrane transport (GO:0035461)2.36047981
132positive regulation of biomineral tissue development (GO:0070169)2.35095796
133adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.34172009
134positive regulation of hormone biosynthetic process (GO:0046886)2.31759336
135hypotonic response (GO:0006971)2.30547846
136regulation of morphogenesis of a branching structure (GO:0060688)2.30492897
137positive regulation of vesicle fusion (GO:0031340)2.29717439
138ribosome assembly (GO:0042255)2.29642240
139regulation of polysaccharide metabolic process (GO:0032881)2.29343142
140carnitine metabolic process (GO:0009437)2.27538528
141cellular response to hydrogen peroxide (GO:0070301)2.25469934
142regulation of microtubule polymerization (GO:0031113)2.25291002
143chemical homeostasis within a tissue (GO:0048875)2.22947149
144membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.22049342
145cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.21731577
146inorganic anion transport (GO:0015698)2.20017187
147regulation of energy homeostasis (GO:2000505)2.18590256
148regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.18199157
149folic acid transport (GO:0015884)2.17282289
150collagen metabolic process (GO:0032963)2.16468353
151pericardium development (GO:0060039)2.16282707
152positive regulation of p38MAPK cascade (GO:1900745)2.16056270
153planar cell polarity pathway involved in neural tube closure (GO:0090179)2.14358214
154positive regulation of multicellular organism growth (GO:0040018)2.11863814
155epithelial cell-cell adhesion (GO:0090136)2.11414837
156collagen catabolic process (GO:0030574)2.11022235
157branching involved in ureteric bud morphogenesis (GO:0001658)2.10911602
158adhesion of symbiont to host cell (GO:0044650)2.10451594
159virion attachment to host cell (GO:0019062)2.10451594
160regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.10166698
161regulation of clathrin-mediated endocytosis (GO:2000369)2.09626385
162regulation of steroid hormone biosynthetic process (GO:0090030)2.09506335
163negative regulation of stem cell differentiation (GO:2000737)2.07560757
164mannose metabolic process (GO:0006013)2.06949249
165negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.06866551
166cellular sodium ion homeostasis (GO:0006883)2.05736368
167regulation of SMAD protein import into nucleus (GO:0060390)2.05146597
168lung vasculature development (GO:0060426)2.05027281
169regulation of response to osmotic stress (GO:0047484)2.03853235
170response to parathyroid hormone (GO:0071107)13.9877045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons4.60331381
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.46652168
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.07503235
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.50270564
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.28868756
6ZNF263_19887448_ChIP-Seq_K562_Human2.98202990
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.77931671
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53528129
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.49063378
10CLOCK_20551151_ChIP-Seq_293T_Human2.38143676
11SOX9_24532713_ChIP-Seq_HFSC_Mouse2.35458981
12RACK7_27058665_Chip-Seq_MCF-7_Human2.21299972
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18521673
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18339502
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.07157690
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.06819851
17SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.02698659
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.02698659
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02665824
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.93989428
21ELK1_22589737_ChIP-Seq_MCF10A_Human1.93081862
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92873532
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.88492396
24KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.87405215
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86380486
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85892597
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77690035
28* TBX20_22328084_ChIP-Seq_HEART_Mouse1.74753007
29* TBX20_22080862_ChIP-Seq_HEART_Mouse1.74753007
30AR_21909140_ChIP-Seq_LNCAP_Human1.70547102
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.70308301
32NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.68150616
33ATF3_27146783_Chip-Seq_COLON_Human1.68002658
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66932516
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.65816951
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.65571067
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.65095344
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.63369261
39BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.62463824
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61019613
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.60907267
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58008309
43NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56490489
44PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53732132
45NFIB_24661679_ChIP-Seq_LUNG_Mouse1.52978990
46* KLF5_25053715_ChIP-Seq_YYC3_Human1.46107868
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44954652
48SOX2_20726797_ChIP-Seq_SW620_Human1.44432301
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41846779
50* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41499660
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40073875
52TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36056291
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36007376
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35066047
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.34438839
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32759910
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31737538
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31612768
59P68_20966046_ChIP-Seq_HELA_Human1.31473803
60OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30871124
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.29456087
62CTCF_21964334_Chip-Seq_Bcells_Human1.29192772
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.28597735
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28153061
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27622406
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27484565
67RXR_22158963_ChIP-Seq_LIVER_Mouse1.27439896
68KDM2B_26808549_Chip-Seq_K562_Human1.26929837
69TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.26196528
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.25999897
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.25498008
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24735079
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24641517
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22082415
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22082415
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22082415
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21802630
78* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20704162
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19577858
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18590138
81EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17470811
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.17294437
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17278630
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17030887
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16765618
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16673403
87CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15732970
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15587930
89TP53_23651856_ChIP-Seq_MEFs_Mouse1.15463701
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15317053
91* CJUN_26792858_Chip-Seq_BT549_Human1.15211531
92CTCF_27219007_Chip-Seq_Bcells_Human1.15188228
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14994446
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14486348
95CREB1_15753290_ChIP-ChIP_HEK293T_Human1.14214265
96SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13159489
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13153361
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13064000
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13023625
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12972019
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12955178
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12925018
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12059074
104TFEB_21752829_ChIP-Seq_HELA_Human1.11126583
105CHD1_26751641_Chip-Seq_LNCaP_Human1.10936613
106UBF1/2_26484160_Chip-Seq_HMECs_Human1.10515988
107EP300_21415370_ChIP-Seq_HL-1_Mouse1.09835894
108* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09494368
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.09331710
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.09069437
111TP53_16413492_ChIP-PET_HCT116_Human1.08214280
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08097053
113CREB1_26743006_Chip-Seq_LNCaP_Human1.07170852
114P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.06800484
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06156949
116SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05570890
117NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04961381
118ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04701740
119XRN2_22483619_ChIP-Seq_HELA_Human1.03890233
120TP53_18474530_ChIP-ChIP_U2OS_Human1.03809313
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03715628
122LXR_22292898_ChIP-Seq_THP-1_Human1.03531955
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02347662
124SMC4_20622854_ChIP-Seq_HELA_Human1.01275013
125TP63_22573176_ChIP-Seq_HFKS_Human1.01233562
126KDM5A_27292631_Chip-Seq_BREAST_Human1.00673133
127SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00081120
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98926325
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98791790
130FOXH1_21741376_ChIP-Seq_ESCs_Human0.96976424
131TET1_21490601_ChIP-Seq_MESCs_Mouse0.96657833
132SA1_22415368_ChIP-Seq_MEFs_Mouse0.96595428
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96376406
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95801580
135TP53_22127205_ChIP-Seq_IMR90_Human0.95730149
136CTCF_20526341_ChIP-Seq_ESCs_Human0.93235646
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92833416
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92630362
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92106496
140* BCOR_27268052_Chip-Seq_Bcells_Human0.91901685
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90919881
142NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90895854
143* TP53_20018659_ChIP-ChIP_R1E_Mouse0.89535642
144GATA1_22025678_ChIP-Seq_K562_Human0.89035712
145PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88833014
146* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88617728
147* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87720993
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86959519
149* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86312664
150TCF7_22412390_ChIP-Seq_EML_Mouse0.84917166
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84224470
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84224470
153GATA6_25053715_ChIP-Seq_YYC3_Human0.83625868
154JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83620089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000681_abnormal_thyroid_gland8.74195856
2MP0000678_abnormal_parathyroid_gland8.31478685
3MP0004043_abnormal_pH_regulation5.58559072
4MP0002876_abnormal_thyroid_physiology3.08433308
5MP0010368_abnormal_lymphatic_system3.06407305
6MP0010234_abnormal_vibrissa_follicle2.93100533
7MP0004084_abnormal_cardiac_muscle2.86165484
8MP0001485_abnormal_pinna_reflex2.85905275
9MP0008004_abnormal_stomach_pH2.80524471
10MP0002234_abnormal_pharynx_morphology2.55001260
11MP0001501_abnormal_sleep_pattern2.44855935
12MP0008995_early_reproductive_senescence2.37886418
13* MP0000383_abnormal_hair_follicle2.35904592
14* MP0010678_abnormal_skin_adnexa2.30720755
15MP0002098_abnormal_vibrissa_morphology2.20142611
16MP0002877_abnormal_melanocyte_morpholog2.14779978
17MP0002796_impaired_skin_barrier2.14461720
18MP0004742_abnormal_vestibular_system2.01661176
19MP0000462_abnormal_digestive_system1.95094284
20MP0009250_abnormal_appendicular_skeleto1.92571967
21MP0004036_abnormal_muscle_relaxation1.86695356
22MP0009053_abnormal_anal_canal1.71299781
23MP0008569_lethality_at_weaning1.70156689
24MP0000579_abnormal_nail_morphology1.67139598
25MP0000537_abnormal_urethra_morphology1.66310858
26MP0005508_abnormal_skeleton_morphology1.57590656
27MP0003693_abnormal_embryo_hatching1.53939306
28MP0005409_darkened_coat_color1.46959947
29MP0000747_muscle_weakness1.44593221
30MP0003566_abnormal_cell_adhesion1.42899724
31MP0003191_abnormal_cellular_cholesterol1.39788106
32MP0000647_abnormal_sebaceous_gland1.36962844
33MP0002896_abnormal_bone_mineralization1.36569101
34MP0010352_gastrointestinal_tract_polyps1.35197272
35MP0001958_emphysema1.35017253
36MP0001756_abnormal_urination1.34984682
37MP0009840_abnormal_foam_cell1.33891080
38MP0005058_abnormal_lysosome_morphology1.31464618
39MP0000026_abnormal_inner_ear1.31134384
40MP0003172_abnormal_lysosome_physiology1.29999794
41MP0004957_abnormal_blastocyst_morpholog1.27255989
42MP0000377_abnormal_hair_follicle1.26834983
43MP0005451_abnormal_body_composition1.26743112
44MP0005381_digestive/alimentary_phenotyp1.25989291
45MP0000762_abnormal_tongue_morphology1.24907970
46MP0000566_synostosis1.24761310
47MP0005377_hearing/vestibular/ear_phenot1.24573290
48MP0003878_abnormal_ear_physiology1.24573290
49MP0000049_abnormal_middle_ear1.24493194
50MP0008260_abnormal_autophagy1.23858944
51MP0008438_abnormal_cutaneous_collagen1.18200512
52MP0003119_abnormal_digestive_system1.18134451
53MP0009643_abnormal_urine_homeostasis1.16049918
54MP0001963_abnormal_hearing_physiology1.15930756
55MP0003868_abnormal_feces_composition1.15031735
56MP0005503_abnormal_tendon_morphology1.14574622
57MP0003786_premature_aging1.12260713
58MP0003656_abnormal_erythrocyte_physiolo1.11638841
59MP0001879_abnormal_lymphatic_vessel1.11134952
60MP0005076_abnormal_cell_differentiation1.10933356
61MP0003705_abnormal_hypodermis_morpholog1.08974773
62MP0003879_abnormal_hair_cell1.08575657
63MP0003123_paternal_imprinting1.07283028
64MP0005623_abnormal_meninges_morphology1.07098233
65MP0004272_abnormal_basement_membrane1.06920676
66MP0000534_abnormal_ureter_morphology1.06317684
67MP0000750_abnormal_muscle_regeneration1.05444576
68MP0002060_abnormal_skin_morphology1.05266842
69MP0005275_abnormal_skin_tensile1.04126270
70MP0001849_ear_inflammation1.01822550
71MP0005501_abnormal_skin_physiology1.01125452
72MP0001730_embryonic_growth_arrest1.00814513
73MP0005257_abnormal_intraocular_pressure0.97225634
74MP0002177_abnormal_outer_ear0.96087336
75MP0004885_abnormal_endolymph0.96040698
76MP0001663_abnormal_digestive_system0.93046062
77* MP0010771_integument_phenotype0.92055680
78MP0003718_maternal_effect0.89113405
79MP0000428_abnormal_craniofacial_morphol0.87228978
80MP0003890_abnormal_embryonic-extraembry0.87038268
81MP0000003_abnormal_adipose_tissue0.84551698
82MP0001346_abnormal_lacrimal_gland0.83424596
83MP0004134_abnormal_chest_morphology0.81254499
84MP0000920_abnormal_myelination0.80324041
85MP0004185_abnormal_adipocyte_glucose0.79612936
86MP0005584_abnormal_enzyme/coenzyme_acti0.79406579
87MP0003091_abnormal_cell_migration0.79352188
88MP0001765_abnormal_ion_homeostasis0.79206867
89MP0000733_abnormal_muscle_development0.75890393
90MP0004264_abnormal_extraembryonic_tissu0.75493463
91MP0003938_abnormal_ear_development0.75264717
92MP0003941_abnormal_skin_development0.75031995
93MP0001216_abnormal_epidermal_layer0.73448291
94MP0000467_abnormal_esophagus_morphology0.72501521
95MP0003075_altered_response_to0.72414894
96MP0002295_abnormal_pulmonary_circulatio0.70254488
97MP0006138_congestive_heart_failure0.69749664
98MP0003950_abnormal_plasma_membrane0.69292821
99MP0008875_abnormal_xenobiotic_pharmacok0.66796742
100MP0003115_abnormal_respiratory_system0.66595898
101MP0002254_reproductive_system_inflammat0.66557772
102MP0003646_muscle_fatigue0.66550035
103MP0003453_abnormal_keratinocyte_physiol0.65634158
104MP0009780_abnormal_chondrocyte_physiolo0.65606848
105MP0003937_abnormal_limbs/digits/tail_de0.65325400
106MP0008775_abnormal_heart_ventricle0.64454345
107MP0003303_peritoneal_inflammation0.63521532
108MP0003942_abnormal_urinary_system0.63457615
109MP0003329_amyloid_beta_deposits0.62349045
110MP0005390_skeleton_phenotype0.61764467
111MP0000163_abnormal_cartilage_morphology0.61625463
112MP0002102_abnormal_ear_morphology0.61258490
113MP0002089_abnormal_postnatal_growth/wei0.60542755
114MP0000631_abnormal_neuroendocrine_gland0.59752719
115MP0003221_abnormal_cardiomyocyte_apopto0.59620173
116MP0001851_eye_inflammation0.57307150
117MP0002249_abnormal_larynx_morphology0.55718101
118MP0004484_altered_response_of0.55374623
119MP0002653_abnormal_ependyma_morphology0.55341375
120MP0000858_altered_metastatic_potential0.55337570
121MP0006036_abnormal_mitochondrial_physio0.54836720
122MP0002092_abnormal_eye_morphology0.54714903
123MP0004782_abnormal_surfactant_physiolog0.54695659
124MP0005380_embryogenesis_phenotype0.54467594
125MP0001672_abnormal_embryogenesis/_devel0.54467594
126MP0010030_abnormal_orbit_morphology0.53664760
127MP0001661_extended_life_span0.53451387
128MP0000013_abnormal_adipose_tissue0.53214158
129MP0002168_other_aberrant_phenotype0.53094685
130MP0003638_abnormal_response/metabolism_0.53060729
131MP0005636_abnormal_mineral_homeostasis0.51654190
132MP0005023_abnormal_wound_healing0.51592526
133MP0003936_abnormal_reproductive_system0.50894019
134MP0008932_abnormal_embryonic_tissue0.50236111
135MP0001440_abnormal_grooming_behavior0.49069859
136MP0008007_abnormal_cellular_replicative0.48961762
137MP0001177_atelectasis0.48678585
138MP0004858_abnormal_nervous_system0.48598221
139MP0002116_abnormal_craniofacial_bone0.47915246
140MP0002136_abnormal_kidney_physiology0.47897235
141* MP0000367_abnormal_coat/_hair0.46854943
142MP0001270_distended_abdomen0.44230150
143MP0000427_abnormal_hair_cycle0.43166682
144MP0001188_hyperpigmentation0.41495090
145MP0000627_abnormal_mammary_gland0.40958564
146* MP0003935_abnormal_craniofacial_develop0.40676115
147MP0009931_abnormal_skin_appearance0.40386828
148MP0002111_abnormal_tail_morphology0.40132098
149MP0003183_abnormal_peptide_metabolism0.40103645
150MP0005193_abnormal_anterior_eye0.39584957
151MP0005375_adipose_tissue_phenotype0.38750667

Predicted human phenotypes

RankGene SetZ-score
1Small epiphyses (HP:0010585)9.15380102
2Tetany (HP:0001281)8.70127178
3Congenital sensorineural hearing impairment (HP:0008527)8.26367953
4Hyperphosphatemia (HP:0002905)7.56904828
5Abnormality of cochlea (HP:0000375)7.43239659
6* Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)7.28138566
7Onycholysis (HP:0001806)6.06865515
8Morphological abnormality of the inner ear (HP:0011390)5.67733552
9Delayed epiphyseal ossification (HP:0002663)5.63669653
10Hypoparathyroidism (HP:0000829)5.56403815
11Mild short stature (HP:0003502)5.29682669
12Thyroid carcinoma (HP:0002890)5.12805321
13Hypothermia (HP:0002045)5.00471304
14Irregular epiphyses (HP:0010582)4.90922796
15Cervical subluxation (HP:0003308)4.39799958
16Muscle fiber splitting (HP:0003555)4.28953435
17Epiphyseal dysplasia (HP:0002656)4.24469800
18* Hypothyroidism (HP:0000821)3.99168193
19Hyperparathyroidism (HP:0000843)3.98438542
20Ulnar deviation of the wrist (HP:0003049)3.84042677
21Fragile nails (HP:0001808)3.56575997
22Split foot (HP:0001839)3.39799096
23Delayed CNS myelination (HP:0002188)3.36038821
24* Coarse facial features (HP:0000280)3.20466429
25Breast hypoplasia (HP:0003187)3.10978649
26Mucopolysacchariduria (HP:0008155)3.00871213
27Urinary glycosaminoglycan excretion (HP:0003541)3.00871213
28Hyperactive renin-angiotensin system (HP:0000841)2.92724924
29Tracheal stenosis (HP:0002777)2.86563427
30Abnormality of the distal phalanges of the toes (HP:0010182)2.80794787
31Difficulty climbing stairs (HP:0003551)2.78725288
32Hyperglycinemia (HP:0002154)2.72047741
33Carpal bone hypoplasia (HP:0001498)2.67926715
34Bradycardia (HP:0001662)2.64806544
35Neonatal respiratory distress (HP:0002643)2.64443658
36Milia (HP:0001056)2.62914148
37Abnormality of polysaccharide metabolism (HP:0011012)2.62558726
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.62558726
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.62558726
40* Constipation (HP:0002019)2.59259602
41* Pili torti (HP:0003777)2.54680791
42Hoarse voice (HP:0001609)2.53966429
43Hyperpituitarism (HP:0010514)2.53305148
44Hypotrichosis (HP:0001006)2.47777272
45Hyperglycinuria (HP:0003108)2.46656242
46Disproportionate short-trunk short stature (HP:0003521)2.46027517
47Hypoplasia of the odontoid process (HP:0003311)2.44087676
48Hypocalcemia (HP:0002901)2.42083267
49Neoplasm of the thyroid gland (HP:0100031)2.40621757
50Prenatal maternal abnormality (HP:0002686)2.38879599
51Nail dystrophy (HP:0008404)2.37790224
52Abnormality of the dental root (HP:0006486)2.37230077
53Taurodontia (HP:0000679)2.37230077
54Abnormality of permanent molar morphology (HP:0011071)2.37230077
55Atrophic scars (HP:0001075)2.35852346
56Ulnar bowing (HP:0003031)2.33245842
57Abnormality of molar (HP:0011077)2.29501974
58Abnormality of molar morphology (HP:0011070)2.29501974
59Macroglossia (HP:0000158)2.29355627
60Abnormality of the dental pulp (HP:0006479)2.24419697
61Bronchomalacia (HP:0002780)2.21359298
62Partial duplication of thumb phalanx (HP:0009944)2.20054377
63Obstructive sleep apnea (HP:0002870)2.16850669
64Chronic bronchitis (HP:0004469)2.14527969
65Achilles tendon contracture (HP:0001771)2.13969659
66Umbilical hernia (HP:0001537)2.13796013
67Genu varum (HP:0002970)2.13331797
68Abnormality of secondary sexual hair (HP:0009888)2.12986953
69Abnormality of the axillary hair (HP:0100134)2.12986953
70Secondary amenorrhea (HP:0000869)2.11107091
71Spinal muscular atrophy (HP:0007269)2.08473405
72Shoulder girdle muscle weakness (HP:0003547)2.03995082
73Partial duplication of the phalanx of hand (HP:0009999)2.03226120
74Pelvic girdle muscle weakness (HP:0003749)2.02551363
75Premature rupture of membranes (HP:0001788)2.01604638
76Urethral obstruction (HP:0000796)2.00198696
77Goiter (HP:0000853)15.9836226
78Thyroid-stimulating hormone excess (HP:0002925)10.1245151
79Abnormality of the odontoid process (HP:0003310)1.99882241
80Rough bone trabeculation (HP:0100670)1.99393229
81Aplasia of the musculature (HP:0100854)1.99219871
82Abnormality of the Achilles tendon (HP:0005109)1.98160118
83Increased connective tissue (HP:0009025)1.97148250
84Abnormality of dental color (HP:0011073)1.94780251
85Abnormality of serine family amino acid metabolism (HP:0010894)1.94154474
86Abnormality of glycine metabolism (HP:0010895)1.94154474
87Upper limb amyotrophy (HP:0009129)1.93392089
88Distal upper limb amyotrophy (HP:0007149)1.93392089
89Aplasia/Hypoplasia involving the musculature (HP:0001460)1.93344879
90Abnormality of the antihelix (HP:0009738)1.89913530
91Difficulty running (HP:0009046)1.88004738
92Ankle contracture (HP:0006466)1.87216065
93Generalized amyotrophy (HP:0003700)1.84180954
94Brittle hair (HP:0002299)1.82498601
95Type I diabetes mellitus (HP:0100651)1.80656915
96Right ventricular cardiomyopathy (HP:0011663)1.77759903
97Vaginal fistula (HP:0004320)1.76935078
98Hyperthyroidism (HP:0000836)1.76628385
99Thoracolumbar scoliosis (HP:0002944)1.74829540
100Short nail (HP:0001799)1.74738134
101Accelerated skeletal maturation (HP:0005616)1.74429664
102Lower limb asymmetry (HP:0100559)1.74027504
103Shallow orbits (HP:0000586)1.73771520
104Osteoarthritis (HP:0002758)1.71139457
105Woolly hair (HP:0002224)1.71093977
106Hand muscle atrophy (HP:0009130)1.70259290
107Broad metatarsal (HP:0001783)1.70088005
108Ovoid vertebral bodies (HP:0003300)1.69612381
109Death in infancy (HP:0001522)1.69355953
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.68630257
111Rectovaginal fistula (HP:0000143)1.67484950
112Rectal fistula (HP:0100590)1.67484950
113Abnormality of the hip-girdle musculature (HP:0001445)1.67199339
114Abnormality of the musculature of the pelvis (HP:0001469)1.67199339
115Hyperacusis (HP:0010780)1.64689769
116Atrioventricular block (HP:0001678)1.62972819
117Ventricular fibrillation (HP:0001663)1.62512518
118Hypoplastic nipples (HP:0002557)1.59591926
119Stenosis of the external auditory canal (HP:0000402)1.58756584
120Alopecia of scalp (HP:0002293)1.58573117
121Respiratory distress (HP:0002098)1.57324798
122Abnormal hemoglobin (HP:0011902)1.56595006
123Protrusio acetabuli (HP:0003179)1.56460073
124Limb-girdle muscle atrophy (HP:0003797)1.53482718
125Flat acetabular roof (HP:0003180)1.53359274
126Selective tooth agenesis (HP:0001592)1.52552137
127Abnormality of the middle phalanges of the toes (HP:0010183)1.51537210
128Abdominal distention (HP:0003270)1.48258580
129Lower limb hyperreflexia (HP:0002395)1.48206555
130Bundle branch block (HP:0011710)1.47945173
131Diaphragmatic weakness (HP:0009113)1.47495880
132Bowed forearm bones (HP:0003956)1.46611221
133Bowing of the arm (HP:0006488)1.46611221
134Renal salt wasting (HP:0000127)1.45065777
135Curly hair (HP:0002212)1.44257629
136Abnormality of the vitreous humor (HP:0004327)1.43846173
137Hypokinesia (HP:0002375)1.43506771
138Sparse lateral eyebrow (HP:0005338)1.41274610
139Laryngomalacia (HP:0001601)1.41131509
140Bladder diverticulum (HP:0000015)1.39003033
141Acanthosis nigricans (HP:0000956)1.37361068
142Ankyloglossia (HP:0010296)1.37249975
143Abnormality of oral frenula (HP:0000190)1.29542741
144Spinal rigidity (HP:0003306)1.29347984
145Thick nail (HP:0001805)1.26448002
146Natal tooth (HP:0000695)1.26069726
147Neonatal hypoglycemia (HP:0001998)1.25806257
148Synostosis involving the elbow (HP:0003938)1.25482592
149Humeroradial synostosis (HP:0003041)1.25482592
150Subacute progressive viral hepatitis (HP:0006572)1.24201015
151Sparse eyelashes (HP:0000653)1.23237326
152Abnormal epiphyseal ossification (HP:0010656)1.22426716
153Labial hypoplasia (HP:0000066)1.22009056
154Fragile skin (HP:0001030)1.21220989
155Hypercortisolism (HP:0001578)1.20770551
156Genu valgum (HP:0002857)1.20252708
157Striae distensae (HP:0001065)1.19239438
158Premature birth (HP:0001622)1.18782498
159Abnormality of the salivary glands (HP:0010286)1.18741646
160Abnormality of nail color (HP:0100643)1.18229999
161Arterial tortuosity (HP:0005116)1.18074194
162Lip pit (HP:0100267)1.16955068
163Atelectasis (HP:0100750)1.16178443
164Interstitial pulmonary disease (HP:0006530)1.16095935
165Germ cell neoplasia (HP:0100728)1.14913726
166Vertebral compression fractures (HP:0002953)1.14725879
167Abnormality of the gastric mucosa (HP:0004295)1.14717356
168Back pain (HP:0003418)1.14450634
169Absent eyelashes (HP:0000561)1.13969573
170Small for gestational age (HP:0001518)1.13881581
171Hypoplastic female external genitalia (HP:0012815)1.13470432
172Arnold-Chiari malformation (HP:0002308)1.13147697
173Overriding aorta (HP:0002623)1.12855727
174Seborrheic dermatitis (HP:0001051)1.12813349
175Mitral stenosis (HP:0001718)1.11577494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.82830616
2TRIB34.25070424
3AKT34.12153744
4EPHA23.49831052
5BUB13.33888884
6NEK13.07852477
7MST42.81548304
8MET2.74020780
9DAPK22.50241098
10SMG12.42326424
11PAK42.32903167
12NME22.32382116
13TSSK62.22604743
14FGFR22.13678563
15MAP2K22.07297690
16WEE12.07120784
17CDK121.88280244
18ERBB31.82363850
19PRKCI1.77815349
20PLK31.71438285
21FER1.69739376
22RPS6KA41.68929022
23LRRK21.63005220
24KSR21.57658819
25NEK21.55402346
26ERN11.54804132
27PDK31.54745095
28PDK41.54745095
29LATS21.54193008
30EPHB21.48138865
31DYRK31.34288808
32STK241.32246720
33TGFBR11.24792809
34STK38L1.23533429
35MAP3K91.17952024
36PAK31.16548060
37PDGFRA1.14617305
38DAPK31.12725879
39PBK1.12543615
40ARAF1.10642306
41MAP3K81.10480392
42MAP2K11.09725865
43LATS11.09720928
44NTRK11.07005363
45MAP3K21.05436077
46DAPK11.02578576
47ALK1.01621184
48DMPK0.99967889
49AURKA0.99498664
50EEF2K0.98530321
51BCR0.97704909
52IRAK30.95238026
53BCKDK0.93302565
54EIF2AK10.91408640
55PAK10.90742224
56MAP3K30.89410431
57EPHB10.88070747
58TTK0.86298500
59RET0.86226194
60STK380.86214191
61SIK10.86172501
62STK30.85451984
63PTK60.82383861
64ILK0.80436426
65PNCK0.80104685
66RIPK10.79657436
67TRPM70.79269673
68PDK20.78781325
69MAPKAPK30.77851534
70BRAF0.77010531
71CSNK1A10.75749143
72CLK10.75307266
73PTK20.74687450
74PLK10.73459246
75STK100.73285820
76NEK90.71354491
77FGFR10.70507397
78LMTK20.69481228
79DDR20.66070701
80TTN0.65908939
81PRPF4B0.65762146
82CSNK1E0.65294657
83CDK80.64795183
84CDK90.64607786
85PHKG20.64259536
86PHKG10.64259536
87TESK10.63652386
88MYLK0.63525389
89PRKD20.62600870
90MAP3K120.61820348
91ICK0.60134180
92BRD40.59270226
93TAF10.58665929
94MAP3K110.58663271
95CSNK1G30.56739928
96TAOK10.55561789
97BRSK10.55251590
98MAP3K60.53573995
99NME10.51475102
100CSNK1A1L0.51017063
101MAPKAPK20.50570236
102CSNK1G10.50193081
103PRKD30.49429149
104JAK10.49398746
105SCYL20.48731372
106KDR0.47109447
107EPHA40.45539287
108MKNK20.45173233
109LIMK10.43883151
110AURKB0.43845994
111MAP3K70.42993586
112PDK10.42942856
113PDPK10.41578600
114CAMKK20.41463103
115RPS6KA20.41277379
116AKT20.41217069
117PRKCZ0.41095651
118MTOR0.40562873
119TYK20.39233712
120PIM20.39119437
121CDK40.37464227
122HIPK20.35886416
123RPS6KB10.34954459
124CSNK1G20.34784420
125EPHA30.34774299
126BMX0.32747557
127PKN20.31919687
128MAPK70.31685636
129NEK60.31413702
130RPS6KB20.30381284
131MELK0.29401015
132ROCK20.29363748
133SIK30.29162242
134DYRK20.28455887
135MAP2K30.28445021
136CSNK2A10.27856495
137PRKD10.27688059
138PRKCG0.26508590
139ABL20.26434938
140MARK20.25499404
141CDK60.25087286
142PDGFRB0.24718622
143PAK20.24594190
144MAPK120.22972428
145RPS6KL10.21405711
146RPS6KC10.21405711
147KSR10.20507996
148ERBB40.20089819
149MAP3K10.19960346
150FGFR40.19763038

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid hormone synthesis_Homo sapiens_hsa049186.46776599
2Vitamin B6 metabolism_Homo sapiens_hsa007504.26384202
3Tyrosine metabolism_Homo sapiens_hsa003502.85917449
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.00744717
5Autoimmune thyroid disease_Homo sapiens_hsa0532010.9409878
6Mineral absorption_Homo sapiens_hsa049781.90996785
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.90721268
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.63659925
9Gastric acid secretion_Homo sapiens_hsa049711.63518216
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58971466
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58725053
12Thyroid cancer_Homo sapiens_hsa052161.31748263
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25036454
14RNA polymerase_Homo sapiens_hsa030201.24000732
15Sulfur metabolism_Homo sapiens_hsa009201.23610850
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16033024
17Adherens junction_Homo sapiens_hsa045201.12233442
18Lysosome_Homo sapiens_hsa041421.08749275
19N-Glycan biosynthesis_Homo sapiens_hsa005101.05516070
20Bile secretion_Homo sapiens_hsa049761.01596304
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01266013
22Inositol phosphate metabolism_Homo sapiens_hsa005621.00057775
23Bladder cancer_Homo sapiens_hsa052190.96295602
24mTOR signaling pathway_Homo sapiens_hsa041500.93823197
25Proteasome_Homo sapiens_hsa030500.93442652
26Linoleic acid metabolism_Homo sapiens_hsa005910.93314913
27Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93022032
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88294701
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87776442
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84965594
31Small cell lung cancer_Homo sapiens_hsa052220.84176020
32TGF-beta signaling pathway_Homo sapiens_hsa043500.84106564
33Renal cell carcinoma_Homo sapiens_hsa052110.82074937
34Glycerophospholipid metabolism_Homo sapiens_hsa005640.79296388
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77092629
36RNA transport_Homo sapiens_hsa030130.76959414
37VEGF signaling pathway_Homo sapiens_hsa043700.76567619
38ECM-receptor interaction_Homo sapiens_hsa045120.75896761
39Histidine metabolism_Homo sapiens_hsa003400.73588762
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73078072
41Endometrial cancer_Homo sapiens_hsa052130.72502340
42Selenocompound metabolism_Homo sapiens_hsa004500.72186158
43Folate biosynthesis_Homo sapiens_hsa007900.70219029
44Oocyte meiosis_Homo sapiens_hsa041140.69164878
45Pancreatic cancer_Homo sapiens_hsa052120.67976948
46Amoebiasis_Homo sapiens_hsa051460.67409581
47Vitamin digestion and absorption_Homo sapiens_hsa049770.66905093
48Hippo signaling pathway_Homo sapiens_hsa043900.66455184
49Regulation of autophagy_Homo sapiens_hsa041400.66034368
50Antigen processing and presentation_Homo sapiens_hsa046120.64636030
51Chronic myeloid leukemia_Homo sapiens_hsa052200.64502384
52Arginine biosynthesis_Homo sapiens_hsa002200.60468024
53Fat digestion and absorption_Homo sapiens_hsa049750.58833080
54Melanoma_Homo sapiens_hsa052180.57678024
55Lysine degradation_Homo sapiens_hsa003100.57617589
56Sphingolipid metabolism_Homo sapiens_hsa006000.57293738
57Notch signaling pathway_Homo sapiens_hsa043300.54965608
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54679112
59Circadian rhythm_Homo sapiens_hsa047100.53516043
60Tight junction_Homo sapiens_hsa045300.53345260
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.53330524
62Non-small cell lung cancer_Homo sapiens_hsa052230.53191822
63Melanogenesis_Homo sapiens_hsa049160.51345036
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51175164
65Pentose phosphate pathway_Homo sapiens_hsa000300.50849066
66Vibrio cholerae infection_Homo sapiens_hsa051100.50534155
67Sulfur relay system_Homo sapiens_hsa041220.49430114
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48135987
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46852712
70Collecting duct acid secretion_Homo sapiens_hsa049660.46691708
71Estrogen signaling pathway_Homo sapiens_hsa049150.45021552
72Proteoglycans in cancer_Homo sapiens_hsa052050.44090875
73Rap1 signaling pathway_Homo sapiens_hsa040150.43799184
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.43730442
75Hedgehog signaling pathway_Homo sapiens_hsa043400.42513082
76Glioma_Homo sapiens_hsa052140.42296434
77Protein digestion and absorption_Homo sapiens_hsa049740.41647403
78MicroRNAs in cancer_Homo sapiens_hsa052060.40605247
79Hepatitis C_Homo sapiens_hsa051600.39815242
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39548517
81Basal cell carcinoma_Homo sapiens_hsa052170.39402036
82Fructose and mannose metabolism_Homo sapiens_hsa000510.39151211
83Galactose metabolism_Homo sapiens_hsa000520.38750217
84Focal adhesion_Homo sapiens_hsa045100.38126724
85Phenylalanine metabolism_Homo sapiens_hsa003600.36962248
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34648330
87HIF-1 signaling pathway_Homo sapiens_hsa040660.34317329
88Other glycan degradation_Homo sapiens_hsa005110.33765171
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33244852
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33130732
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.32789840
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31876263
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.31568305
94Acute myeloid leukemia_Homo sapiens_hsa052210.31039587
95Colorectal cancer_Homo sapiens_hsa052100.30947630
96Glutathione metabolism_Homo sapiens_hsa004800.30810179
97Insulin signaling pathway_Homo sapiens_hsa049100.30771085
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30668325
99Spliceosome_Homo sapiens_hsa030400.29960213
100Ether lipid metabolism_Homo sapiens_hsa005650.29943230
101cAMP signaling pathway_Homo sapiens_hsa040240.29595083
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29527908
103Prion diseases_Homo sapiens_hsa050200.29156506
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28758744
105Carbon metabolism_Homo sapiens_hsa012000.28654466
106Pathways in cancer_Homo sapiens_hsa052000.28512137
107Long-term potentiation_Homo sapiens_hsa047200.27778625
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26687739
109Ribosome_Homo sapiens_hsa030100.26445668
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25815621
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25155225
112Dilated cardiomyopathy_Homo sapiens_hsa054140.25106528
113p53 signaling pathway_Homo sapiens_hsa041150.24991519
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24026423
115Apoptosis_Homo sapiens_hsa042100.22099711
116Biosynthesis of amino acids_Homo sapiens_hsa012300.21887060
117Salivary secretion_Homo sapiens_hsa049700.21511904
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21248210
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21189467
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21115870
121Axon guidance_Homo sapiens_hsa043600.20284015
122beta-Alanine metabolism_Homo sapiens_hsa004100.20010341
123Insulin resistance_Homo sapiens_hsa049310.19411172
124Protein export_Homo sapiens_hsa030600.19381982
125Amphetamine addiction_Homo sapiens_hsa050310.19335420
126Arachidonic acid metabolism_Homo sapiens_hsa005900.19201245
127Glucagon signaling pathway_Homo sapiens_hsa049220.18949964
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18005110
129Pyrimidine metabolism_Homo sapiens_hsa002400.17846627
130Arginine and proline metabolism_Homo sapiens_hsa003300.17702336
131AMPK signaling pathway_Homo sapiens_hsa041520.17459165
132Prostate cancer_Homo sapiens_hsa052150.17389796
133Phototransduction_Homo sapiens_hsa047440.17339941
134Shigellosis_Homo sapiens_hsa051310.17028947
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.16684722
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.16178974
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16058826
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15674818
139Endocytosis_Homo sapiens_hsa041440.14827199
140Glycerolipid metabolism_Homo sapiens_hsa005610.14322355
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.14255351
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.13755979
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13498681
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12286140
145GnRH signaling pathway_Homo sapiens_hsa049120.12195771
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11071104
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10372768
148Pancreatic secretion_Homo sapiens_hsa049720.09789213

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