FOXF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)7.02970682
2blood vessel maturation (GO:0001955)6.85769268
3positive regulation of endothelial cell differentiation (GO:0045603)6.69635060
4regulation of endothelial cell differentiation (GO:0045601)6.66460133
5morphogenesis of an endothelium (GO:0003159)6.19026123
6endothelial tube morphogenesis (GO:0061154)6.19026123
7lymphangiogenesis (GO:0001946)6.14873423
8chemical homeostasis within a tissue (GO:0048875)5.37189295
9lymph vessel development (GO:0001945)5.33546207
10protein heterotrimerization (GO:0070208)5.30060752
11artery development (GO:0060840)5.21908925
12type B pancreatic cell proliferation (GO:0044342)4.86772516
13regulation of vasculogenesis (GO:2001212)4.86665957
14adhesion of symbiont to host cell (GO:0044650)4.86263228
15virion attachment to host cell (GO:0019062)4.86263228
16extracellular matrix assembly (GO:0085029)4.80144000
17vascular endothelial growth factor signaling pathway (GO:0038084)4.66128839
18endodermal cell differentiation (GO:0035987)4.65507421
19skin morphogenesis (GO:0043589)4.62655633
20positive regulation of vasculogenesis (GO:2001214)4.60969808
21axon extension involved in axon guidance (GO:0048846)4.45111896
22neuron projection extension involved in neuron projection guidance (GO:1902284)4.45111896
23mesenchymal-epithelial cell signaling (GO:0060638)4.44980810
24positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.40311770
25pericardium development (GO:0060039)4.38598585
26kidney mesenchyme development (GO:0072074)4.34318192
27endothelial cell differentiation (GO:0045446)4.31868702
28collagen fibril organization (GO:0030199)4.27488128
29cell proliferation involved in metanephros development (GO:0072203)4.22179006
30renal filtration (GO:0097205)4.17046873
31adhesion of symbiont to host (GO:0044406)4.03932189
32endothelium development (GO:0003158)4.00482382
33cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.97630558
34hippo signaling (GO:0035329)3.97341423
35glomerular filtration (GO:0003094)3.97106080
36* respiratory tube development (GO:0030323)3.94268155
37blood vessel remodeling (GO:0001974)3.84529309
38wound healing, spreading of epidermal cells (GO:0035313)3.82191638
39retina vasculature morphogenesis in camera-type eye (GO:0061299)3.80873093
40cell proliferation involved in kidney development (GO:0072111)3.77847740
41basement membrane organization (GO:0071711)3.67315230
42endothelial cell morphogenesis (GO:0001886)3.67158442
43cellular response to vitamin (GO:0071295)3.65780520
44* endocardial cushion development (GO:0003197)3.64492757
45negative regulation of smooth muscle cell migration (GO:0014912)3.63914618
46tooth mineralization (GO:0034505)3.60636904
47patterning of blood vessels (GO:0001569)3.58667820
48organ formation (GO:0048645)3.58649743
49negative regulation of viral release from host cell (GO:1902187)3.57132907
50positive regulation of endothelial cell apoptotic process (GO:2000353)3.57106299
51muscle cell migration (GO:0014812)3.56010829
52atrioventricular valve morphogenesis (GO:0003181)3.50773329
53anterior/posterior axis specification, embryo (GO:0008595)3.48267559
54negative regulation of cell fate specification (GO:0009996)3.44395815
55metanephric mesenchyme development (GO:0072075)3.43541463
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.43318370
57* vasculogenesis (GO:0001570)3.42971744
58collagen metabolic process (GO:0032963)3.42436504
59regulation of heart morphogenesis (GO:2000826)3.42254015
60cell migration involved in sprouting angiogenesis (GO:0002042)3.38849510
61positive regulation of BMP signaling pathway (GO:0030513)3.38137936
62hypotonic response (GO:0006971)3.34938289
63sequestering of extracellular ligand from receptor (GO:0035581)3.32324890
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.32321829
65heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.30401410
66collagen catabolic process (GO:0030574)3.28866951
67blood vessel endothelial cell migration (GO:0043534)3.26953157
68endothelial cell proliferation (GO:0001935)3.26828626
69multicellular organismal macromolecule metabolic process (GO:0044259)3.23177436
70diaphragm development (GO:0060539)3.21782560
71facial nerve structural organization (GO:0021612)3.21335512
72ganglion development (GO:0061548)3.20557403
73* mesodermal cell differentiation (GO:0048333)3.20042120
74mesenchymal cell proliferation (GO:0010463)3.15491442
75negative regulation of stem cell proliferation (GO:2000647)3.15377475
76smooth muscle tissue development (GO:0048745)3.14917101
77* lung vasculature development (GO:0060426)3.13442694
78aorta morphogenesis (GO:0035909)3.13236404
79regulation of glucocorticoid metabolic process (GO:0031943)3.11635575
80multicellular organismal catabolic process (GO:0044243)3.11454974
81planar cell polarity pathway involved in neural tube closure (GO:0090179)3.11364104
82regulation of smooth muscle cell migration (GO:0014910)3.10759164
83endocardial cushion morphogenesis (GO:0003203)3.10693066
84cell migration involved in heart development (GO:0060973)3.10202477
85negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.09929243
86mesenchymal cell differentiation involved in kidney development (GO:0072161)3.09223760
87mesenchymal cell differentiation involved in renal system development (GO:2001012)3.09223760
88regulation of axon extension involved in axon guidance (GO:0048841)3.09210117
89* artery morphogenesis (GO:0048844)3.08590407
90* vasculature development (GO:0001944)3.08483340
91positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.08145236
92mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.06953796
93positive regulation of osteoblast proliferation (GO:0033690)3.05373213
94multicellular organismal metabolic process (GO:0044236)3.05234694
95vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.04184803
96cellular response to nitric oxide (GO:0071732)3.03855314
97response to xenobiotic stimulus (GO:0009410)3.03100584
98negative regulation of vascular permeability (GO:0043116)3.02566567
99barbed-end actin filament capping (GO:0051016)3.02285427
100embryonic heart tube development (GO:0035050)3.01834641
101negative regulation of chondrocyte differentiation (GO:0032331)2.99218839
102cell surface receptor signaling pathway involved in heart development (GO:0061311)2.99141720
103extracellular fibril organization (GO:0043206)2.98025386
104cell adhesion mediated by integrin (GO:0033627)2.97174987
105apoptotic cell clearance (GO:0043277)2.96503735
106positive regulation of macroautophagy (GO:0016239)2.94694764
107chondrocyte proliferation (GO:0035988)2.94109490
108cellular response to vitamin D (GO:0071305)2.92511714
109positive regulation of astrocyte differentiation (GO:0048711)2.91967598
110coronary vasculature morphogenesis (GO:0060977)2.90545499
111substrate adhesion-dependent cell spreading (GO:0034446)2.89166742
112hyaluronan catabolic process (GO:0030214)2.88862710
113sprouting angiogenesis (GO:0002040)2.87447091
114regulation of collagen metabolic process (GO:0010712)2.87351058
115fibril organization (GO:0097435)2.87277098
116* lung alveolus development (GO:0048286)2.87168099
117extracellular matrix disassembly (GO:0022617)2.86409518
118bone trabecula formation (GO:0060346)2.86109891
119radial glial cell differentiation (GO:0060019)2.85460803
120ectodermal placode formation (GO:0060788)2.85388412
121regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.84929425
122negative regulation of catenin import into nucleus (GO:0035414)2.84922787
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84798795
124positive regulation of cartilage development (GO:0061036)2.84103029
125positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.83543077
126cell differentiation involved in metanephros development (GO:0072202)2.83239486
127regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.82564677
128substrate-dependent cell migration (GO:0006929)2.82368905
129response to BMP (GO:0071772)2.82366073
130cellular response to BMP stimulus (GO:0071773)2.82366073
131positive regulation of macrophage activation (GO:0043032)2.80963235
132mesenchyme morphogenesis (GO:0072132)2.80010540
133negative regulation of embryonic development (GO:0045992)2.79066821
134regulation of glomerular filtration (GO:0003093)2.78826302
135outflow tract morphogenesis (GO:0003151)2.78615737
136positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.78281887
137regulation of integrin-mediated signaling pathway (GO:2001044)2.77936885
138proteoglycan biosynthetic process (GO:0030166)2.77676680
139protein localization to cell surface (GO:0034394)2.77140917
140positive regulation of collagen biosynthetic process (GO:0032967)2.75924147
141dermatan sulfate biosynthetic process (GO:0030208)2.75757469
142* blood vessel morphogenesis (GO:0048514)2.75591878
143regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75534166
144lung-associated mesenchyme development (GO:0060484)2.75480934
145regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.75272324
146negative regulation of hormone biosynthetic process (GO:0032353)2.69959131
147regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.69717616
148positive regulation of hormone biosynthetic process (GO:0046886)2.69544574
149regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.69185882
150regulation of SMAD protein import into nucleus (GO:0060390)2.69053706
151positive regulation of chondrocyte differentiation (GO:0032332)2.68921170
152regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.68390947
153positive regulation of blood vessel endothelial cell migration (GO:0043536)2.68005841
154regulation of response to osmotic stress (GO:0047484)2.67714858
155negative regulation of platelet activation (GO:0010544)2.67595036
156negative regulation of osteoblast proliferation (GO:0033689)2.67343797
157dorsal/ventral axis specification (GO:0009950)2.65340471
158skeletal muscle organ development (GO:0060538)2.65049460
159regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64324051
160dermatan sulfate metabolic process (GO:0030205)2.64299300
161positive regulation of epithelial to mesenchymal transition (GO:0010718)2.63539425
162venous blood vessel morphogenesis (GO:0048845)2.63293271
163positive regulation of fibroblast migration (GO:0010763)2.62562547
164negative regulation of axon guidance (GO:1902668)2.62397981
165negative regulation of androgen receptor signaling pathway (GO:0060766)2.61480154
166craniofacial suture morphogenesis (GO:0097094)2.61473338
167negative regulation of cell junction assembly (GO:1901889)2.61273511
168response to increased oxygen levels (GO:0036296)2.60426675
169response to hyperoxia (GO:0055093)2.60426675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.62569573
2CLOCK_20551151_ChIP-Seq_293T_Human3.67529705
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.13730591
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.01896829
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.96712758
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79304464
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62764056
8GATA2_21666600_ChIP-Seq_HMVEC_Human2.60551008
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60491433
10GATA1_22025678_ChIP-Seq_K562_Human2.53957202
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.53822699
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.38051335
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.24182759
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.21516647
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21305675
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20568554
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.20332748
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.16796411
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.14892459
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.12920567
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.07951873
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.07080403
23SALL4_18804426_ChIP-ChIP_XEN_Mouse2.01845408
24EP300_21415370_ChIP-Seq_HL-1_Mouse2.01788204
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.01760809
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.93937060
27SMC1_22415368_ChIP-Seq_MEFs_Mouse1.93375922
28TP53_22127205_ChIP-Seq_IMR90_Human1.93062999
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.91589489
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.87747805
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.85884921
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.83664701
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.83393877
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81944852
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79567267
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77506238
37ISL1_27105846_Chip-Seq_CPCs_Mouse1.76096549
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75239682
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75015604
40CJUN_26792858_Chip-Seq_BT549_Human1.71765963
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.71555277
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69527554
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67552996
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67552996
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67552996
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65935481
47BRD4_25478319_ChIP-Seq_HGPS_Human1.65505349
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63635670
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63468195
50SMC3_22415368_ChIP-Seq_MEFs_Mouse1.62192209
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61699065
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61699065
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58553263
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58313889
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58305821
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.57709575
57ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55504130
58TP53_16413492_ChIP-PET_HCT116_Human1.54176141
59SOX2_20726797_ChIP-Seq_SW620_Human1.53565162
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53279958
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52844122
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.52651273
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.51734017
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51061854
65SA1_22415368_ChIP-Seq_MEFs_Mouse1.49710083
66* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47995865
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.47815593
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44021831
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40941514
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40941514
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40838541
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39240695
73AR_21909140_ChIP-Seq_LNCAP_Human1.36967327
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36569514
75MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.36230975
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32362197
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.30077120
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.30077120
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29868813
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29635596
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.28890163
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.28835516
83* UBF1/2_26484160_Chip-Seq_HMECs_Human1.27489423
84AHR_22903824_ChIP-Seq_MCF-7_Human1.27387298
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26538353
86* TP53_18474530_ChIP-ChIP_U2OS_Human1.25951100
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25238492
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24246709
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21982011
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21800618
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21224601
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20610013
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19174143
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17795753
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16274483
96BCAT_22108803_ChIP-Seq_LS180_Human1.14189755
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.13707899
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12654011
99* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12127574
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11849966
101* RACK7_27058665_Chip-Seq_MCF-7_Human1.11005052
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10971397
103TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10893241
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10149966
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10106768
106FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09723332
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08726747
108RNF2_27304074_Chip-Seq_ESCs_Mouse1.07751412
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07667655
110SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07268198
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05696726
112NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05595224
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05595224
114JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02843056
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.02109134
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01705453
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01048431
118ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98833303
119EZH2_27304074_Chip-Seq_ESCs_Mouse0.97257778
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97160976
121GATA4_25053715_ChIP-Seq_YYC3_Human0.96879972
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.95591248
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92600562
124* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.91093342
125STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88995925
126LXR_22292898_ChIP-Seq_THP-1_Human0.88981329
127WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88417189
128JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87205567
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86664328
130PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86457887
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86412434
132TET1_21490601_ChIP-Seq_MESCs_Mouse0.86407818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.20346870
2MP0001879_abnormal_lymphatic_vessel4.38370635
3MP0005257_abnormal_intraocular_pressure3.97547661
4MP0004272_abnormal_basement_membrane3.80000199
5MP0001958_emphysema3.60301351
6MP0005167_abnormal_blood-brain_barrier3.36885339
7MP0008438_abnormal_cutaneous_collagen3.15357833
8MP0001542_abnormal_bone_strength3.13906877
9MP0006054_spinal_hemorrhage2.79103890
10MP0004782_abnormal_surfactant_physiolog2.68100935
11MP0003705_abnormal_hypodermis_morpholog2.66992992
12MP0005623_abnormal_meninges_morphology2.53994173
13MP0000537_abnormal_urethra_morphology2.49356981
14MP0005503_abnormal_tendon_morphology2.48488977
15MP0010030_abnormal_orbit_morphology2.40860070
16MP0002138_abnormal_hepatobiliary_system2.25753424
17MP0000767_abnormal_smooth_muscle2.24271235
18MP0003950_abnormal_plasma_membrane2.14674458
19MP0003279_aneurysm2.09421241
20MP0005367_renal/urinary_system_phenotyp2.06358964
21MP0000516_abnormal_urinary_system2.06358964
22MP0003385_abnormal_body_wall2.04982613
23MP0003122_maternal_imprinting2.02443180
24MP0005275_abnormal_skin_tensile2.00050845
25MP0009384_cardiac_valve_regurgitation1.97941176
26MP0000534_abnormal_ureter_morphology1.79452315
27MP0000751_myopathy1.64082388
28MP0003941_abnormal_skin_development1.63365172
29MP0003566_abnormal_cell_adhesion1.61873469
30MP0006138_congestive_heart_failure1.61451894
31MP0002295_abnormal_pulmonary_circulatio1.60719032
32MP0002249_abnormal_larynx_morphology1.59831478
33MP0003828_pulmonary_edema1.59828906
34MP0002254_reproductive_system_inflammat1.59072690
35MP0003115_abnormal_respiratory_system1.58568918
36MP0003123_paternal_imprinting1.56846283
37MP0003448_altered_tumor_morphology1.53782669
38MP0002877_abnormal_melanocyte_morpholog1.50721417
39MP0009053_abnormal_anal_canal1.48321185
40MP0008004_abnormal_stomach_pH1.46795418
41MP0002282_abnormal_trachea_morphology1.45922446
42MP0005388_respiratory_system_phenotype1.42734848
43MP0002133_abnormal_respiratory_system1.42734848
44MP0003567_abnormal_fetal_cardiomyocyte1.42515328
45MP0003935_abnormal_craniofacial_develop1.42186724
46MP0002132_abnormal_respiratory_system1.41869266
47MP0001986_abnormal_taste_sensitivity1.39654470
48MP0001299_abnormal_eye_distance/1.38631515
49MP0003942_abnormal_urinary_system1.37061685
50MP0005595_abnormal_vascular_smooth1.36788035
51MP0002925_abnormal_cardiovascular_devel1.36451273
52MP0003091_abnormal_cell_migration1.32799708
53MP0000013_abnormal_adipose_tissue1.31372651
54MP0005390_skeleton_phenotype1.30998732
55MP0005508_abnormal_skeleton_morphology1.30869330
56MP0001243_abnormal_dermal_layer1.30851734
57MP0000538_abnormal_urinary_bladder1.29208578
58MP0009780_abnormal_chondrocyte_physiolo1.28164780
59MP0003724_increased_susceptibility_to1.28128915
60MP0001175_abnormal_lung_morphology1.26165501
61MP0010386_abnormal_urinary_bladder1.24475714
62MP0000049_abnormal_middle_ear1.24472192
63MP0000249_abnormal_blood_vessel1.24431186
64MP0003937_abnormal_limbs/digits/tail_de1.24232778
65MP0009250_abnormal_appendicular_skeleto1.24230883
66MP0005248_abnormal_Harderian_gland1.23297262
67MP0002060_abnormal_skin_morphology1.22794112
68MP0005197_abnormal_uvea_morphology1.21072600
69MP0002128_abnormal_blood_circulation1.19399696
70MP0001348_abnormal_lacrimal_gland1.19077039
71MP0008995_early_reproductive_senescence1.16952543
72MP0001614_abnormal_blood_vessel1.15603508
73MP0000566_synostosis1.12200132
74MP0002932_abnormal_joint_morphology1.11790751
75MP0000465_gastrointestinal_hemorrhage1.09603436
76MP0005023_abnormal_wound_healing1.09541064
77MP0009840_abnormal_foam_cell1.07912353
78MP0004883_abnormal_blood_vessel1.05970139
79MP0001664_abnormal_digestion1.04706745
80MP0000858_altered_metastatic_potential1.04203650
81MP0000762_abnormal_tongue_morphology1.03167376
82MP0003119_abnormal_digestive_system1.01595848
83MP0000462_abnormal_digestive_system1.01356751
84MP0001270_distended_abdomen1.00814557
85MP0002277_abnormal_respiratory_mucosa1.00784036
86MP0010352_gastrointestinal_tract_polyps0.99950491
87MP0005187_abnormal_penis_morphology0.99735694
88MP0005164_abnormal_response_to0.98194392
89MP0001533_abnormal_skeleton_physiology0.98125846
90MP0002127_abnormal_cardiovascular_syste0.98065321
91MP0003283_abnormal_digestive_organ0.95686448
92MP0004510_myositis0.95485910
93MP0002938_white_spotting0.94995786
94MP0003300_gastrointestinal_ulcer0.92490137
95MP0003755_abnormal_palate_morphology0.90455031
96MP0000733_abnormal_muscle_development0.90095635
97MP0005408_hypopigmentation0.90076790
98MP0005084_abnormal_gallbladder_morpholo0.89565729
99MP0004858_abnormal_nervous_system0.89247242
100MP0000428_abnormal_craniofacial_morphol0.89221659
101MP0000613_abnormal_salivary_gland0.88747984
102MP0002086_abnormal_extraembryonic_tissu0.88215811
103MP0001177_atelectasis0.85927927
104MP0002933_joint_inflammation0.85017579
105MP0003121_genomic_imprinting0.83313139
106MP0002998_abnormal_bone_remodeling0.83037193
107MP0000266_abnormal_heart_morphology0.82903239
108MP0001849_ear_inflammation0.82541664
109MP0005385_cardiovascular_system_phenoty0.82375568
110MP0001544_abnormal_cardiovascular_syste0.82375568
111MP0010234_abnormal_vibrissa_follicle0.80397589
112MP0001915_intracranial_hemorrhage0.79617212
113MP0010307_abnormal_tumor_latency0.79091591
114MP0002115_abnormal_skeleton_extremities0.78769625
115MP0000750_abnormal_muscle_regeneration0.76653264
116MP0000432_abnormal_head_morphology0.76568111
117MP0000163_abnormal_cartilage_morphology0.76317515
118MP0004197_abnormal_fetal_growth/weight/0.75071705
119MP0000343_altered_response_to0.73987493
120MP0008875_abnormal_xenobiotic_pharmacok0.73516230
121MP0001784_abnormal_fluid_regulation0.71883088
122MP0003943_abnormal_hepatobiliary_system0.71117580
123MP0000678_abnormal_parathyroid_gland0.70875116
124MP0004084_abnormal_cardiac_muscle0.70030668
125MP0003191_abnormal_cellular_cholesterol0.69736765
126MP0004134_abnormal_chest_morphology0.68557010
127MP0002108_abnormal_muscle_morphology0.67450005
128MP0002896_abnormal_bone_mineralization0.67182217
129MP0002177_abnormal_outer_ear0.66810764
130MP0002089_abnormal_postnatal_growth/wei0.66498318
131MP0002109_abnormal_limb_morphology0.65857449
132MP0002113_abnormal_skeleton_development0.65232659
133MP0003984_embryonic_growth_retardation0.64539540
134MP0001293_anophthalmia0.64393850
135MP0002088_abnormal_embryonic_growth/wei0.63719275
136MP0003795_abnormal_bone_structure0.59902065
137MP0003436_decreased_susceptibility_to0.59130994
138MP0005165_increased_susceptibility_to0.58422926
139MP0005076_abnormal_cell_differentiation0.57504513
140MP0004808_abnormal_hematopoietic_stem0.53624614
141MP0005381_digestive/alimentary_phenotyp0.52738860
142MP0005620_abnormal_muscle_contractility0.52585496

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)6.23951863
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)6.23951863
3Hematochezia (HP:0002573)5.06415980
4Polycythemia (HP:0001901)4.85266094
5Spontaneous hematomas (HP:0007420)4.46531833
6Abnormality of the 4th metacarpal (HP:0010012)4.45042836
7Aortic aneurysm (HP:0004942)4.26904928
8Slender build (HP:0001533)4.19867216
9Midline defect of the nose (HP:0004122)4.19571244
10Abnormality of dentin (HP:0010299)3.94757072
11Broad metatarsal (HP:0001783)3.83083704
12Cerebral aneurysm (HP:0004944)3.75326984
13Aortic dissection (HP:0002647)3.66041064
14Ankle contracture (HP:0006466)3.64386284
15Interstitial pulmonary disease (HP:0006530)3.62417129
16Shallow orbits (HP:0000586)3.61938368
17Spondylolisthesis (HP:0003302)3.48916859
18Protrusio acetabuli (HP:0003179)3.46988294
19Neonatal short-limb short stature (HP:0008921)3.39053959
20Camptodactyly of toe (HP:0001836)3.36989732
21Fragile skin (HP:0001030)3.36062168
22Cervical subluxation (HP:0003308)3.27547431
23Genu recurvatum (HP:0002816)3.27348338
24Hypoventilation (HP:0002791)3.21345984
25Peritonitis (HP:0002586)3.15664339
26Blue sclerae (HP:0000592)3.15409422
27Premature rupture of membranes (HP:0001788)3.14696560
28Shawl scrotum (HP:0000049)3.12745427
29Long toe (HP:0010511)3.09387070
30Esophageal varix (HP:0002040)3.05254074
31Hyperactive renin-angiotensin system (HP:0000841)3.00290561
32Pulmonary artery stenosis (HP:0004415)2.99728355
33Conjunctival telangiectasia (HP:0000524)2.98429952
34Renal duplication (HP:0000075)2.86442355
35Visceral angiomatosis (HP:0100761)2.79419913
36Mitral valve prolapse (HP:0001634)2.74038564
37Bowel diverticulosis (HP:0005222)2.73591585
38Abnormality of the nasal mucosa (HP:0000433)2.73435487
39Vertebral compression fractures (HP:0002953)2.73372781
40Hemangiomatosis (HP:0007461)2.59229859
41Asymmetry of the thorax (HP:0001555)2.58154363
42Lymphangioma (HP:0100764)2.57202934
43Aortic regurgitation (HP:0001659)2.56883030
44Joint contractures involving the joints of the feet (HP:0100492)2.54594245
45Flexion contracture of toe (HP:0005830)2.54594245
46Thoracolumbar scoliosis (HP:0002944)2.53362163
47Bladder diverticulum (HP:0000015)2.49790914
48Overgrowth (HP:0001548)2.49341790
49Wrist flexion contracture (HP:0001239)2.48848971
50Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47225030
51Osteolytic defects of the hand bones (HP:0009699)2.43845333
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.43845333
53Abnormality of skeletal muscle fiber size (HP:0012084)2.40363658
54Aneurysm (HP:0002617)2.36476231
55Dilatation of the ascending aorta (HP:0005111)2.35077319
56Ulnar bowing (HP:0003031)2.34786690
57Deep venous thrombosis (HP:0002625)2.32582958
58Hyperextensible skin (HP:0000974)2.31538544
59Wide cranial sutures (HP:0010537)2.29627851
60Bicuspid aortic valve (HP:0001647)2.27411145
61Disproportionate tall stature (HP:0001519)2.25677087
62Achilles tendon contracture (HP:0001771)2.24659833
63Knee flexion contracture (HP:0006380)2.23074816
64Abnormality of the parietal bone (HP:0002696)2.22573797
65Generalized amyotrophy (HP:0003700)2.21585358
66Abnormality of the distal phalanx of the thumb (HP:0009617)2.21402085
67Spinal rigidity (HP:0003306)2.20990217
68Atrophic scars (HP:0001075)2.20413998
69Chronic bronchitis (HP:0004469)2.20115222
70Wide anterior fontanel (HP:0000260)2.19620626
71Biconcave vertebral bodies (HP:0004586)2.19189916
72Vascular tortuosity (HP:0004948)2.18643718
73Rectal prolapse (HP:0002035)2.16742057
74Nonimmune hydrops fetalis (HP:0001790)2.16242340
75Follicular hyperkeratosis (HP:0007502)2.15576047
76Short nail (HP:0001799)2.11675884
77Broad toe (HP:0001837)2.07573494
78Syringomyelia (HP:0003396)2.07442427
79Spinal cord lesions (HP:0100561)2.07442427
80Arterial tortuosity (HP:0005116)2.05749718
81Abnormality of the acetabulum (HP:0003170)2.05322878
82Subacute progressive viral hepatitis (HP:0006572)2.05023299
83Abnormal delivery (HP:0001787)2.03005557
84Facial shape deformation (HP:0011334)2.00178604
85Potter facies (HP:0002009)2.00178604
86Deviation of the hallux (HP:0010051)1.99075220
87* Pulmonary hypertension (HP:0002092)1.97414608
88Mesomelia (HP:0003027)1.97136180
89Ovoid vertebral bodies (HP:0003300)1.96638094
90Aplasia/Hypoplasia of the clavicles (HP:0006710)1.96085323
91Limb-girdle muscle weakness (HP:0003325)1.95315786
92Venous insufficiency (HP:0005293)1.95036287
93Upper limb amyotrophy (HP:0009129)1.94138158
94Distal upper limb amyotrophy (HP:0007149)1.94138158
95Arachnodactyly (HP:0001166)1.93086491
96Coronal craniosynostosis (HP:0004440)1.92900404
97Anteriorly placed anus (HP:0001545)1.92559491
98Abnormality of the Achilles tendon (HP:0005109)1.92499999
99Hallux valgus (HP:0001822)1.91630154
100Short clavicles (HP:0000894)1.91137778
101Natal tooth (HP:0000695)1.90324499
102Redundant skin (HP:0001582)1.88987860
103Cutaneous finger syndactyly (HP:0010554)1.82228043
104Short hallux (HP:0010109)1.82210225
105Joint stiffness (HP:0001387)1.81507443
106Neoplasm of the heart (HP:0100544)1.81033650
107Inguinal hernia (HP:0000023)1.80714267
108Cerebral hemorrhage (HP:0001342)1.80277889
109Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80143964
110Keratoconus (HP:0000563)1.79184964
111Increased corneal curvature (HP:0100692)1.79184964
112Intestinal polyp (HP:0005266)1.78078950
113* Abnormality of the fetal cardiovascular system (HP:0010948)1.77091077
114* Abnormal umbilical cord blood vessels (HP:0011403)1.77091077
115* Single umbilical artery (HP:0001195)1.77091077
116Portal hypertension (HP:0001409)1.76654960
117Joint laxity (HP:0001388)1.76063624
118Delayed cranial suture closure (HP:0000270)1.75981488
119Intestinal polyposis (HP:0200008)1.75697128
120Round ear (HP:0100830)1.75366925
121Nemaline bodies (HP:0003798)1.75250517
122Down-sloping shoulders (HP:0200021)1.73821290
123Mildly elevated creatine phosphokinase (HP:0008180)1.72925431
124Trigonocephaly (HP:0000243)1.71557140
125Soft skin (HP:0000977)1.71294991
126Elbow flexion contracture (HP:0002987)1.70612059
127Venous abnormality (HP:0002624)1.70147896
128Aortic valve stenosis (HP:0001650)1.70112486
129Premature skin wrinkling (HP:0100678)1.69997537
130Mucosal telangiectasiae (HP:0100579)1.69644995
131Abnormal ossification of hand bones (HP:0005921)1.69282233
132Protruding ear (HP:0000411)1.68679333
133Ectopia lentis (HP:0001083)1.68172164
134Hypoplasia of the maxilla (HP:0000327)1.66975319
135Type 1 muscle fiber predominance (HP:0003803)1.66753487
136Broad hallux (HP:0010055)1.66569740
137Mitral regurgitation (HP:0001653)1.66519862
138Cupped ribs (HP:0000887)1.66502915
139Increased variability in muscle fiber diameter (HP:0003557)1.66481181
140Femoral bowing (HP:0002980)1.66041356
141Osteopenia (HP:0000938)1.65483947
142Absent eyebrow (HP:0002223)1.65467482
143Broad face (HP:0000283)1.65300225
144Wormian bones (HP:0002645)1.64168983
145Supernumerary ribs (HP:0005815)1.63644207
146Selective tooth agenesis (HP:0001592)1.63582483
147Thin bony cortex (HP:0002753)1.63466350
148Increased connective tissue (HP:0009025)1.62829360
149Skull defect (HP:0001362)1.62785431
150Delayed closure of the anterior fontanelle (HP:0001476)1.62389610
151Congenital glaucoma (HP:0001087)1.62358136
152Bronchomalacia (HP:0002780)1.62176105
153Bowing of the arm (HP:0006488)1.61977056
154Bowed forearm bones (HP:0003956)1.61977056
155Hyperacusis (HP:0010780)1.61341264
156Buphthalmos (HP:0000557)1.60338998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.06173395
2GRK74.02052239
3TGFBR23.99537398
4EPHA33.93152962
5EPHB23.73082575
6RIPK13.10328801
7LATS13.07738727
8KDR3.06963422
9TGFBR12.95259726
10TTN2.81063328
11MYLK2.76227903
12PDGFRA2.73691620
13GRK52.42451597
14PIK3CG2.40340397
15NTRK12.19776390
16PTK62.03033608
17PAK41.99240506
18GRK11.89356321
19ERBB41.82935704
20DDR21.77203778
21AKT31.73136353
22FGFR21.71220921
23ADRBK21.69935872
24LRRK21.68782168
25FER1.67811056
26PTK2B1.61424311
27TRIB31.59930497
28PIM21.50514329
29DMPK1.46916134
30FLT31.42918181
31CDC42BPA1.41510942
32LATS21.40026962
33MAP3K101.36522460
34PTK21.35357747
35PNCK1.32559609
36MET1.31757831
37PAK21.28818271
38ERN11.28559146
39STK31.27358884
40STK101.16801352
41SMG11.15662500
42MELK1.15556165
43PDGFRB1.09178806
44IRAK31.01420244
45SIK10.99670927
46STK380.99604951
47FGFR40.99344749
48TAOK20.99225009
49GRK60.98988387
50JAK10.94249815
51MOS0.92735040
52CDK120.92389244
53ILK0.89821499
54PRKG20.88470369
55PKN20.87750379
56DYRK1B0.85932155
57NUAK10.83774958
58EPHB10.78984533
59MAP2K30.75247408
60CSK0.75164377
61RPS6KA20.73810696
62CDK60.72541391
63FGFR10.71682561
64RPS6KA40.70002784
65TRPM70.67619397
66PRPF4B0.64940158
67PRKD10.64374659
68GSK3A0.63651463
69PAK60.61061448
70NEK90.60871693
71CLK10.58768764
72BMX0.57934291
73ROCK10.57852491
74FGFR30.57790386
75PRKCH0.53139012
76MAP3K80.52728611
77TESK10.52537527
78ERBB20.51575119
79MTOR0.51413327
80MAP3K30.50945717
81CAMK2G0.48876506
82MAP2K20.47458951
83MAPK40.46992781
84MKNK20.46690117
85PRKD20.45913414
86CAMK1D0.45549713
87TLK10.45297292
88EPHA20.42521567
89MAP3K50.41692223
90STK38L0.40593365
91SRC0.40149242
92EGFR0.38966165
93MAPKAPK20.36606765
94TYK20.35966273
95MKNK10.35810048
96INSR0.33513371
97TBK10.33321947
98ICK0.33173052
99HIPK20.32275025
100ADRBK10.32218762
101TAF10.30451341
102DAPK30.30263487
103MAP3K140.28984291
104MAPK70.28446671
105CDK80.28354281
106CHUK0.28211766
107ZAK0.28059835
108ROCK20.27787624
109IGF1R0.27296892
110SRPK10.27083070
111PLK20.26994073
112NLK0.26894265
113CDK90.26099700
114ERBB30.25473790
115JAK30.25002357
116PAK10.24921022
117KIT0.24910359
118LIMK10.24540538
119MAP2K10.22961803
120MAP3K70.22497238
121TEC0.21565759
122PDPK10.21441696
123BRD40.20973106
124CDK70.20944582
125CAMK1G0.20821760
126RPS6KL10.20465806
127RPS6KC10.20465806
128CSNK1A1L0.20372574
129ABL10.19992637
130RPS6KA60.19519130
131PRKAA20.18622092
132STK40.18344954
133MARK30.17507362
134ABL20.16822830
135AKT20.16229121
136MST1R0.16144477
137ZAP700.15511122
138CSNK1G10.14272955
139BUB10.14154260

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.48147006
2ECM-receptor interaction_Homo sapiens_hsa045123.22401689
3Adherens junction_Homo sapiens_hsa045203.07105387
4Basal cell carcinoma_Homo sapiens_hsa052172.80809762
5Focal adhesion_Homo sapiens_hsa045102.79355571
6TGF-beta signaling pathway_Homo sapiens_hsa043502.46000355
7Hippo signaling pathway_Homo sapiens_hsa043902.32226500
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.28869017
9Leukocyte transendothelial migration_Homo sapiens_hsa046702.22429217
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.17369055
11Proteoglycans in cancer_Homo sapiens_hsa052052.08718710
12Hedgehog signaling pathway_Homo sapiens_hsa043402.02585733
13Small cell lung cancer_Homo sapiens_hsa052221.96553084
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.96362986
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.88851743
16Notch signaling pathway_Homo sapiens_hsa043301.78998094
17Tight junction_Homo sapiens_hsa045301.77433724
18MicroRNAs in cancer_Homo sapiens_hsa052061.77359086
19Axon guidance_Homo sapiens_hsa043601.70283531
20Rap1 signaling pathway_Homo sapiens_hsa040151.65401138
21Platelet activation_Homo sapiens_hsa046111.61841761
22Other glycan degradation_Homo sapiens_hsa005111.58149108
23Renin-angiotensin system_Homo sapiens_hsa046141.55336337
24Pathways in cancer_Homo sapiens_hsa052001.54494604
25Sulfur metabolism_Homo sapiens_hsa009201.53477845
26Bladder cancer_Homo sapiens_hsa052191.51623819
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49663496
28Complement and coagulation cascades_Homo sapiens_hsa046101.49548254
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47835683
30Amoebiasis_Homo sapiens_hsa051461.47392117
31Caffeine metabolism_Homo sapiens_hsa002321.45664743
32Protein digestion and absorption_Homo sapiens_hsa049741.45621639
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.41854687
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37952691
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.37742792
36Systemic lupus erythematosus_Homo sapiens_hsa053221.34122361
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30307903
38Malaria_Homo sapiens_hsa051441.30008899
39Prion diseases_Homo sapiens_hsa050201.29265733
40Renal cell carcinoma_Homo sapiens_hsa052111.25012332
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24018888
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19614890
43Prostate cancer_Homo sapiens_hsa052151.15763376
44Melanogenesis_Homo sapiens_hsa049161.15357291
45Dorso-ventral axis formation_Homo sapiens_hsa043201.14826770
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12592687
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10553910
48HTLV-I infection_Homo sapiens_hsa051661.09798211
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08624908
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08282298
51Dilated cardiomyopathy_Homo sapiens_hsa054141.06781350
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.04751591
53Chronic myeloid leukemia_Homo sapiens_hsa052201.04082270
54Viral myocarditis_Homo sapiens_hsa054161.03042253
55Wnt signaling pathway_Homo sapiens_hsa043101.01472055
56Thyroid cancer_Homo sapiens_hsa052160.99995115
57p53 signaling pathway_Homo sapiens_hsa041150.99247809
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98904699
59Renin secretion_Homo sapiens_hsa049240.96694072
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95472430
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95448854
62Gap junction_Homo sapiens_hsa045400.91325880
63Selenocompound metabolism_Homo sapiens_hsa004500.90345290
64Pancreatic cancer_Homo sapiens_hsa052120.87799490
65N-Glycan biosynthesis_Homo sapiens_hsa005100.87666551
66Toxoplasmosis_Homo sapiens_hsa051450.87034339
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86004863
68Melanoma_Homo sapiens_hsa052180.85334942
69Vibrio cholerae infection_Homo sapiens_hsa051100.84731972
70Colorectal cancer_Homo sapiens_hsa052100.83213138
71Ovarian steroidogenesis_Homo sapiens_hsa049130.79793336
72Nitrogen metabolism_Homo sapiens_hsa009100.78607561
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77340381
74Lysosome_Homo sapiens_hsa041420.76475021
75beta-Alanine metabolism_Homo sapiens_hsa004100.76413430
76Shigellosis_Homo sapiens_hsa051310.76151685
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75709742
78Tryptophan metabolism_Homo sapiens_hsa003800.75664513
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.75204636
80VEGF signaling pathway_Homo sapiens_hsa043700.74701202
81Mineral absorption_Homo sapiens_hsa049780.74447315
82Cocaine addiction_Homo sapiens_hsa050300.74271374
83Viral carcinogenesis_Homo sapiens_hsa052030.73666795
84Ras signaling pathway_Homo sapiens_hsa040140.67393502
85Pertussis_Homo sapiens_hsa051330.67360631
86Hepatitis B_Homo sapiens_hsa051610.65539028
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65501277
88Endocytosis_Homo sapiens_hsa041440.65083528
89Salmonella infection_Homo sapiens_hsa051320.64295888
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61043882
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59367599
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58817331
93Endometrial cancer_Homo sapiens_hsa052130.58598037
94TNF signaling pathway_Homo sapiens_hsa046680.58268688
95African trypanosomiasis_Homo sapiens_hsa051430.57619641
96Bile secretion_Homo sapiens_hsa049760.57451944
97Retinol metabolism_Homo sapiens_hsa008300.57046565
98Cell cycle_Homo sapiens_hsa041100.55442320
99HIF-1 signaling pathway_Homo sapiens_hsa040660.55147154
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.54102650
101Estrogen signaling pathway_Homo sapiens_hsa049150.54085902
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52136458
103Phagosome_Homo sapiens_hsa041450.51953053
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51821172
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.51776717
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51629588
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51517627
108Alcoholism_Homo sapiens_hsa050340.50749031
109Chemical carcinogenesis_Homo sapiens_hsa052040.50415783
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.49751889
111Insulin resistance_Homo sapiens_hsa049310.48468376
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.46447440
113Thyroid hormone synthesis_Homo sapiens_hsa049180.46014667
114Apoptosis_Homo sapiens_hsa042100.45754580
115Histidine metabolism_Homo sapiens_hsa003400.45661998
116Staphylococcus aureus infection_Homo sapiens_hsa051500.45320686
117Glutathione metabolism_Homo sapiens_hsa004800.45104690
118FoxO signaling pathway_Homo sapiens_hsa040680.44493710
119Lysine degradation_Homo sapiens_hsa003100.42706385
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42607072
121Prolactin signaling pathway_Homo sapiens_hsa049170.42444330
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42286615
123MAPK signaling pathway_Homo sapiens_hsa040100.41784375
124Glioma_Homo sapiens_hsa052140.40716265
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40414509
126Calcium signaling pathway_Homo sapiens_hsa040200.38212829
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35259170
128Hepatitis C_Homo sapiens_hsa051600.34552759
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34517592
130cAMP signaling pathway_Homo sapiens_hsa040240.33065568
131GnRH signaling pathway_Homo sapiens_hsa049120.31574021
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30399423

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