FOXG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.70118203
2vocalization behavior (GO:0071625)5.48688384
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.36301330
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35218835
5layer formation in cerebral cortex (GO:0021819)5.26808277
6locomotory exploration behavior (GO:0035641)5.22921232
7neuron cell-cell adhesion (GO:0007158)5.15678804
8ionotropic glutamate receptor signaling pathway (GO:0035235)5.09406883
9regulation of glutamate receptor signaling pathway (GO:1900449)5.08963123
10protein localization to synapse (GO:0035418)5.00419506
11olfactory bulb development (GO:0021772)4.85896882
12tongue development (GO:0043586)4.73078338
13cell proliferation in forebrain (GO:0021846)4.70780360
14synaptic vesicle exocytosis (GO:0016079)4.61459141
15axonal fasciculation (GO:0007413)4.58300107
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.53043034
17limb bud formation (GO:0060174)4.50679384
18synaptic vesicle maturation (GO:0016188)4.48096002
19glutamate receptor signaling pathway (GO:0007215)4.45456153
20* neuron recognition (GO:0008038)4.45037186
21somite development (GO:0061053)4.44744898
22dendritic spine morphogenesis (GO:0060997)4.44267459
23positive regulation of synapse maturation (GO:0090129)4.44081248
24exploration behavior (GO:0035640)4.43631989
25negative regulation of astrocyte differentiation (GO:0048712)4.42096495
26central nervous system projection neuron axonogenesis (GO:0021952)4.37315180
27synaptic transmission, glutamatergic (GO:0035249)4.30986356
28regulation of neuronal synaptic plasticity (GO:0048168)4.27802387
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.25167324
30postsynaptic membrane organization (GO:0001941)4.24022168
31regulation of synaptic vesicle exocytosis (GO:2000300)4.21791056
32glutamate secretion (GO:0014047)4.19582647
33regulation of dendritic spine morphogenesis (GO:0061001)4.19309309
34regulation of synapse structural plasticity (GO:0051823)4.19100527
35regulation of timing of cell differentiation (GO:0048505)4.13869162
36neurotransmitter-gated ion channel clustering (GO:0072578)4.07253860
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02966151
38regulation of development, heterochronic (GO:0040034)4.02885674
39negative regulation of transcription regulatory region DNA binding (GO:2000678)4.02626586
40forebrain neuron differentiation (GO:0021879)4.00644409
41neuron-neuron synaptic transmission (GO:0007270)3.98920002
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.98551440
43presynaptic membrane assembly (GO:0097105)3.98400347
44cell migration in hindbrain (GO:0021535)3.90988305
45positive regulation of dendritic spine morphogenesis (GO:0061003)3.89094521
46regulation of synaptic vesicle transport (GO:1902803)3.83855890
47* cerebral cortex radially oriented cell migration (GO:0021799)3.83544957
48spinal cord development (GO:0021510)3.80375295
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.80212329
50dendrite morphogenesis (GO:0048813)3.79381412
51synaptic vesicle endocytosis (GO:0048488)3.77227080
52presynaptic membrane organization (GO:0097090)3.72653714
53regulation of synapse maturation (GO:0090128)3.68652021
54behavioral fear response (GO:0001662)3.65791863
55behavioral defense response (GO:0002209)3.65791863
56DNA double-strand break processing (GO:0000729)3.61775262
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61681593
58long-term memory (GO:0007616)3.56960149
59regulation of dendritic spine development (GO:0060998)3.56402544
60regulation of postsynaptic membrane potential (GO:0060078)3.55642581
61G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.54679711
62regulation of synaptic plasticity (GO:0048167)3.54652938
63positive regulation of dendritic spine development (GO:0060999)3.50230336
64transmission of nerve impulse (GO:0019226)3.48812607
65neurotransmitter secretion (GO:0007269)3.48359763
66long-term synaptic potentiation (GO:0060291)3.46913834
67positive regulation of membrane potential (GO:0045838)3.45086262
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44062421
69neuronal action potential propagation (GO:0019227)3.43942171
70central nervous system neuron axonogenesis (GO:0021955)3.40053133
71dendritic spine organization (GO:0097061)3.39235849
72* cerebral cortex cell migration (GO:0021795)3.38162185
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35090297
74fear response (GO:0042596)3.34821693
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.33586249
76proline transport (GO:0015824)3.33515136
77pyrimidine nucleobase catabolic process (GO:0006208)3.33152343
78gamma-aminobutyric acid transport (GO:0015812)3.31514396
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.26074000
80cerebellar granule cell differentiation (GO:0021707)3.25239578
81mechanosensory behavior (GO:0007638)3.22161080
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18853994
83negative regulation of glial cell differentiation (GO:0045686)3.18239089
84regulation of female receptivity (GO:0045924)3.17745985
85positive regulation of neurotransmitter secretion (GO:0001956)3.14830904
86learning (GO:0007612)3.14114017
87synapse assembly (GO:0007416)3.13801959
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12998975
89positive regulation of synapse assembly (GO:0051965)3.10934826
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06436126
91regulation of neurotransmitter secretion (GO:0046928)3.05694687
92neural tube formation (GO:0001841)3.03912445
93auditory behavior (GO:0031223)3.03726530
94establishment of mitochondrion localization (GO:0051654)3.03550098
95regulation of vesicle fusion (GO:0031338)3.02854183
96cerebral cortex neuron differentiation (GO:0021895)3.02760879
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02475766
98neuromuscular process controlling balance (GO:0050885)3.01758128
99limb development (GO:0060173)2.99434614
100appendage development (GO:0048736)2.99434614
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98634296
102hippocampus development (GO:0021766)2.98171786
103neuronal ion channel clustering (GO:0045161)2.98053263
104substrate-independent telencephalic tangential migration (GO:0021826)2.97768385
105substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.97768385
106oligodendrocyte differentiation (GO:0048709)2.97741111
107axon extension (GO:0048675)2.97731811
108dentate gyrus development (GO:0021542)2.97525162
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97231584
110nucleobase catabolic process (GO:0046113)2.93748784
111glial cell proliferation (GO:0014009)2.93309620
112ephrin receptor signaling pathway (GO:0048013)2.93060701
113dopamine receptor signaling pathway (GO:0007212)2.91128011
114nonmotile primary cilium assembly (GO:0035058)2.90211028
115regulation of synapse organization (GO:0050807)2.89152600
116calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.88752129
117response to histamine (GO:0034776)2.87609230
118female mating behavior (GO:0060180)2.86991929
119regulation of synaptic transmission, GABAergic (GO:0032228)2.86085564
120regulation of synaptic transmission (GO:0050804)2.85486984
121membrane depolarization (GO:0051899)2.83996525
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.83539197
123neurotransmitter transport (GO:0006836)2.83282586
124cochlea development (GO:0090102)2.83083346
125regulation of dendrite morphogenesis (GO:0048814)2.83064649
126regulation of respiratory system process (GO:0044065)2.81802709
127intraciliary transport (GO:0042073)2.80680791
128retinal ganglion cell axon guidance (GO:0031290)2.78450220
129* forebrain cell migration (GO:0021885)2.76781960
130negative regulation of gliogenesis (GO:0014014)2.75667093
131positive regulation of male gonad development (GO:2000020)2.73167862
132glycosphingolipid biosynthetic process (GO:0006688)2.72814996
133* telencephalon cell migration (GO:0022029)2.72458059
134startle response (GO:0001964)2.71799103
135C4-dicarboxylate transport (GO:0015740)2.71634544
136cranial nerve morphogenesis (GO:0021602)2.67097978
137negative regulation of oligodendrocyte differentiation (GO:0048715)2.66710208
138cornea development in camera-type eye (GO:0061303)2.65694900
139atrial cardiac muscle cell action potential (GO:0086014)2.64489362
140protein polyglutamylation (GO:0018095)2.63325088
141artery development (GO:0060840)2.62897329
142cellular response to cholesterol (GO:0071397)2.62261529
143epithelial cilium movement (GO:0003351)2.62201934
144central nervous system myelination (GO:0022010)2.60472566
145axon ensheathment in central nervous system (GO:0032291)2.60472566
146neuronal stem cell maintenance (GO:0097150)2.59659930
147adult walking behavior (GO:0007628)2.59457335
148cardiac ventricle formation (GO:0003211)2.58020712
149otic vesicle formation (GO:0030916)2.57706088
150head development (GO:0060322)2.55490358
151behavioral response to nicotine (GO:0035095)2.55465817
152regulation of non-canonical Wnt signaling pathway (GO:2000050)2.55405350
153replication fork processing (GO:0031297)2.54818012
154neuron fate commitment (GO:0048663)2.53625635
155* positive regulation of neuroblast proliferation (GO:0002052)2.53393414
156regulation of astrocyte differentiation (GO:0048710)2.53092352
157* dorsal/ventral pattern formation (GO:0009953)2.52341304
158axonogenesis (GO:0007409)2.48265466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.14761020
2GBX2_23144817_ChIP-Seq_PC3_Human3.59677443
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.30944881
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16719110
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98508356
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.86458580
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.84328627
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83285484
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83285484
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.81432016
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73982984
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68794692
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.67182455
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58052887
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.55571527
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.49851574
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44715184
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.43308523
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41336067
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.41293336
21* RARB_27405468_Chip-Seq_BRAIN_Mouse2.35107701
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33342684
23DROSHA_22980978_ChIP-Seq_HELA_Human2.21250793
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10074326
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97883820
26AR_21572438_ChIP-Seq_LNCaP_Human1.97110451
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96537494
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.89677400
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85072684
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81930512
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81856006
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75814043
33VDR_22108803_ChIP-Seq_LS180_Human1.75218511
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74359358
35* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72216968
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71915538
37* CBX2_27304074_Chip-Seq_ESCs_Mouse1.71841064
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70931442
39EWS_26573619_Chip-Seq_HEK293_Human1.69887765
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65047397
41* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63434886
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61529946
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59423018
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58586524
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.57110264
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56413633
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.53325715
48* RING1B_27294783_Chip-Seq_ESCs_Mouse1.52041766
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.49563097
50TAF15_26573619_Chip-Seq_HEK293_Human1.48360629
51* RING1B_27294783_Chip-Seq_NPCs_Mouse1.47892535
52ZNF274_21170338_ChIP-Seq_K562_Hela1.47801674
53P300_19829295_ChIP-Seq_ESCs_Human1.45378573
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.40980199
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40899173
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35908015
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34452820
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34128745
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29014879
60CBP_20019798_ChIP-Seq_JUKART_Human1.29014879
61* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27762881
62RNF2_27304074_Chip-Seq_NSC_Mouse1.26287815
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.24913751
64* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24671474
65* SOX9_26525672_Chip-Seq_HEART_Mouse1.23830431
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23363814
67* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23000456
68IRF1_19129219_ChIP-ChIP_H3396_Human1.22845967
69* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22589299
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.21832508
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21378624
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20939049
73TP53_18474530_ChIP-ChIP_U2OS_Human1.20887672
74IGF1R_20145208_ChIP-Seq_DFB_Human1.20026905
75* AR_25329375_ChIP-Seq_VCAP_Human1.19285814
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18436087
77* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16611185
78* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16580130
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16185650
80ER_23166858_ChIP-Seq_MCF-7_Human1.16048272
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15545935
82AR_19668381_ChIP-Seq_PC3_Human1.15513284
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15487302
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15238148
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.14517841
86FUS_26573619_Chip-Seq_HEK293_Human1.13502259
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12654389
88AHR_22903824_ChIP-Seq_MCF-7_Human1.10344858
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10197463
90* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09588070
91STAT3_23295773_ChIP-Seq_U87_Human1.09217271
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09015909
93TP53_16413492_ChIP-PET_HCT116_Human1.08662783
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07833310
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07725547
96* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07074451
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06885837
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06147352
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06126390
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06126390
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05090137
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04115881
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03890436
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03669468
105BCAT_22108803_ChIP-Seq_LS180_Human1.03178396
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02271014
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.02026269
108* TP53_20018659_ChIP-ChIP_R1E_Mouse1.01924667
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01821940
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.01706407
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01487683
112KDM2B_26808549_Chip-Seq_K562_Human1.01406011
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00826367
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.00800648
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00767754
116SOX2_16153702_ChIP-ChIP_HESCs_Human1.00472489
117RUNX2_22187159_ChIP-Seq_PCA_Human1.00183757
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99654153
119JUN_21703547_ChIP-Seq_K562_Human0.99366161
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99366082
121* TCF4_23295773_ChIP-Seq_U87_Human0.99090463
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99074605
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.96872044
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96212166
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94871859
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94658174
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93788386
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93772723
129* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93478093
130* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93343801
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.91393887
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90861060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.61148559
2MP0003880_abnormal_central_pattern4.74910242
3MP0003635_abnormal_synaptic_transmissio4.08924850
4MP0004270_analgesia3.60096453
5MP0002063_abnormal_learning/memory/cond3.55925435
6MP0009745_abnormal_behavioral_response3.36607053
7MP0002064_seizures2.91331850
8* MP0000778_abnormal_nervous_system2.87618340
9MP0002572_abnormal_emotion/affect_behav2.81682140
10MP0001968_abnormal_touch/_nociception2.78037175
11MP0005423_abnormal_somatic_nervous2.60699717
12MP0001486_abnormal_startle_reflex2.47227877
13MP0003122_maternal_imprinting2.46903560
14MP0002736_abnormal_nociception_after2.38530586
15MP0002734_abnormal_mechanical_nocicepti2.38129500
16MP0009046_muscle_twitch2.33284921
17MP0002822_catalepsy2.32007615
18MP0002735_abnormal_chemical_nociception2.31798573
19MP0002272_abnormal_nervous_system2.16741714
20MP0010030_abnormal_orbit_morphology2.13553684
21* MP0008789_abnormal_olfactory_epithelium2.11649069
22MP0004858_abnormal_nervous_system2.05690201
23MP0002184_abnormal_innervation2.00070468
24MP0009780_abnormal_chondrocyte_physiolo1.99390918
25MP0001440_abnormal_grooming_behavior1.97382672
26MP0002557_abnormal_social/conspecific_i1.96905733
27MP0002733_abnormal_thermal_nociception1.95070908
28MP0004885_abnormal_endolymph1.91429783
29MP0009053_abnormal_anal_canal1.90007887
30MP0001188_hyperpigmentation1.88681798
31* MP0004811_abnormal_neuron_physiology1.85249215
32MP0003121_genomic_imprinting1.82064353
33MP0001501_abnormal_sleep_pattern1.79987321
34MP0001970_abnormal_pain_threshold1.78899595
35MP0001293_anophthalmia1.77375530
36MP0002067_abnormal_sensory_capabilities1.74230142
37MP0003329_amyloid_beta_deposits1.66839516
38MP0005386_behavior/neurological_phenoty1.62020259
39MP0004924_abnormal_behavior1.62020259
40MP0000955_abnormal_spinal_cord1.60585477
41MP0003787_abnormal_imprinting1.57458147
42* MP0002882_abnormal_neuron_morphology1.55063784
43MP0005646_abnormal_pituitary_gland1.51124838
44MP0008877_abnormal_DNA_methylation1.47196730
45MP0008569_lethality_at_weaning1.46046310
46MP0006072_abnormal_retinal_apoptosis1.44408621
47* MP0002152_abnormal_brain_morphology1.41766056
48MP0001984_abnormal_olfaction1.41301394
49* MP0002233_abnormal_nose_morphology1.38743691
50* MP0002066_abnormal_motor_capabilities/c1.37674959
51MP0006276_abnormal_autonomic_nervous1.34301998
52MP0004133_heterotaxia1.29921005
53MP0003879_abnormal_hair_cell1.29696615
54MP0002938_white_spotting1.28484781
55MP0003937_abnormal_limbs/digits/tail_de1.27059597
56MP0003136_yellow_coat_color1.25317189
57MP0002909_abnormal_adrenal_gland1.24492647
58MP0000537_abnormal_urethra_morphology1.21633191
59* MP0000631_abnormal_neuroendocrine_gland1.20780676
60* MP0005195_abnormal_posterior_eye1.15122838
61* MP0003861_abnormal_nervous_system1.15029674
62MP0005409_darkened_coat_color1.13540229
63MP0005253_abnormal_eye_physiology1.11366834
64MP0001286_abnormal_eye_development1.10734967
65MP0009379_abnormal_foot_pigmentation1.10082606
66MP0000534_abnormal_ureter_morphology1.09980614
67MP0005645_abnormal_hypothalamus_physiol1.09172233
68* MP0000428_abnormal_craniofacial_morphol1.08754128
69MP0001502_abnormal_circadian_rhythm1.08285147
70MP0001905_abnormal_dopamine_level1.05667749
71* MP0005391_vision/eye_phenotype1.00814302
72MP0001529_abnormal_vocalization0.99103686
73MP0002069_abnormal_eating/drinking_beha0.98027881
74MP0004742_abnormal_vestibular_system0.97447500
75MP0005367_renal/urinary_system_phenotyp0.96672588
76MP0000516_abnormal_urinary_system0.96672588
77MP0003942_abnormal_urinary_system0.96395343
78MP0002697_abnormal_eye_size0.96238612
79MP0003890_abnormal_embryonic-extraembry0.93844185
80MP0002282_abnormal_trachea_morphology0.92548936
81* MP0003938_abnormal_ear_development0.91205322
82MP0001963_abnormal_hearing_physiology0.90974306
83* MP0002752_abnormal_somatic_nervous0.90830019
84MP0000647_abnormal_sebaceous_gland0.90759007
85MP0003634_abnormal_glial_cell0.89475928
86MP0004142_abnormal_muscle_tone0.87782412
87MP0002653_abnormal_ependyma_morphology0.87021256
88* MP0003633_abnormal_nervous_system0.86463471
89* MP0000026_abnormal_inner_ear0.85994095
90MP0005248_abnormal_Harderian_gland0.85375191
91* MP0002092_abnormal_eye_morphology0.84175265
92MP0005187_abnormal_penis_morphology0.82304943
93MP0003385_abnormal_body_wall0.82005568
94* MP0003631_nervous_system_phenotype0.81944667
95MP0001346_abnormal_lacrimal_gland0.81831916
96MP0000579_abnormal_nail_morphology0.81694576
97* MP0000049_abnormal_middle_ear0.80781139
98MP0003935_abnormal_craniofacial_develop0.79357333
99MP0010386_abnormal_urinary_bladder0.78198768
100* MP0001177_atelectasis0.76874088
101MP0000613_abnormal_salivary_gland0.75661717
102MP0003119_abnormal_digestive_system0.75644263
103MP0005623_abnormal_meninges_morphology0.75544410
104* MP0005499_abnormal_olfactory_system0.75353800
105* MP0005394_taste/olfaction_phenotype0.75353800
106MP0002102_abnormal_ear_morphology0.75332245
107MP0001485_abnormal_pinna_reflex0.74863651
108MP0004085_abnormal_heartbeat0.74690330
109MP0000566_synostosis0.74326641
110MP0002249_abnormal_larynx_morphology0.73976978
111MP0000569_abnormal_digit_pigmentation0.72296831
112MP0008874_decreased_physiological_sensi0.70724780
113MP0003632_abnormal_nervous_system0.69699847
114MP0005171_absent_coat_pigmentation0.68333595
115* MP0002081_perinatal_lethality0.67609397
116* MP0006292_abnormal_olfactory_placode0.67471158
117MP0005551_abnormal_eye_electrophysiolog0.66878843
118MP0002751_abnormal_autonomic_nervous0.64507905
119* MP0003755_abnormal_palate_morphology0.62171639
120* MP0002116_abnormal_craniofacial_bone0.61954848
121MP0002082_postnatal_lethality0.61698030
122MP0010770_preweaning_lethality0.61698030
123MP0010769_abnormal_survival0.61064997
124MP0003137_abnormal_impulse_conducting0.60970437
125* MP0002229_neurodegeneration0.60492822
126MP0002638_abnormal_pupillary_reflex0.60328517
127MP0000015_abnormal_ear_pigmentation0.59583079
128MP0001664_abnormal_digestion0.58663920
129MP0001348_abnormal_lacrimal_gland0.58259788
130MP0010768_mortality/aging0.57230975
131* MP0001943_abnormal_respiration0.56807713
132MP0008872_abnormal_physiological_respon0.55749298

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.57527931
2Myokymia (HP:0002411)5.50606385
3Focal seizures (HP:0007359)4.95460364
4Epileptic encephalopathy (HP:0200134)4.60388225
5Hyperventilation (HP:0002883)4.24216276
6Visual hallucinations (HP:0002367)4.07002571
7Febrile seizures (HP:0002373)3.69739463
8Broad-based gait (HP:0002136)3.64085209
9Short 4th metacarpal (HP:0010044)3.60499368
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.60499368
11Atonic seizures (HP:0010819)3.57310515
12True hermaphroditism (HP:0010459)3.45570581
13Absence seizures (HP:0002121)3.42130707
14Supranuclear gaze palsy (HP:0000605)3.31243976
15Oligodactyly (HP:0012165)3.28599560
16Megalencephaly (HP:0001355)3.18485869
17Dialeptic seizures (HP:0011146)3.14730908
18Abnormality of the 4th metacarpal (HP:0010012)3.14111459
19Progressive cerebellar ataxia (HP:0002073)3.13389949
20Obstructive sleep apnea (HP:0002870)3.12731751
21Generalized tonic-clonic seizures (HP:0002069)3.06438164
22Amblyopia (HP:0000646)3.04151183
23Septo-optic dysplasia (HP:0100842)3.01750209
24Abnormality of the labia minora (HP:0012880)2.99949389
25Cerebral inclusion bodies (HP:0100314)2.93339526
26Facial hemangioma (HP:0000329)2.89289273
27Absent speech (HP:0001344)2.88958607
28Colon cancer (HP:0003003)2.88850363
29Nephronophthisis (HP:0000090)2.85678004
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.82445028
31Pancreatic fibrosis (HP:0100732)2.82411250
32Epileptiform EEG discharges (HP:0011182)2.72009218
33Molar tooth sign on MRI (HP:0002419)2.71227961
34Abnormality of midbrain morphology (HP:0002418)2.71227961
35* Excessive salivation (HP:0003781)2.67917961
36* Drooling (HP:0002307)2.67917961
37Rib fusion (HP:0000902)2.67916952
38Hemiparesis (HP:0001269)2.65888691
39Abnormality of the aortic arch (HP:0012303)2.64167053
40Mutism (HP:0002300)2.63009299
41Optic nerve hypoplasia (HP:0000609)2.60798176
42EEG with generalized epileptiform discharges (HP:0011198)2.58603502
43Thickened helices (HP:0000391)2.58187466
44Neurofibrillary tangles (HP:0002185)2.57432333
45Ectopic kidney (HP:0000086)2.56701394
46Oligodactyly (hands) (HP:0001180)2.55391653
47Action tremor (HP:0002345)2.55161787
48Genetic anticipation (HP:0003743)2.52481583
49Impaired vibration sensation in the lower limbs (HP:0002166)2.51766320
50Postaxial foot polydactyly (HP:0001830)2.51231843
51* Stereotypic behavior (HP:0000733)2.48572267
52Limb dystonia (HP:0002451)2.47909764
53* Poor eye contact (HP:0000817)2.47612785
54Pancreatic cysts (HP:0001737)2.45897535
55Hypsarrhythmia (HP:0002521)2.45411671
56Progressive inability to walk (HP:0002505)2.45175458
57Gait imbalance (HP:0002141)2.42409721
58Ankle clonus (HP:0011448)2.41481729
59Urinary bladder sphincter dysfunction (HP:0002839)2.40891146
60Anxiety (HP:0000739)2.39298896
61Renal hypoplasia (HP:0000089)2.39270171
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.38927488
63Depression (HP:0000716)2.37877394
64Amyotrophic lateral sclerosis (HP:0007354)2.34901857
65Abnormality of the diencephalon (HP:0010662)2.33562058
66Abnormality of the renal medulla (HP:0100957)2.28110861
67Abnormal eating behavior (HP:0100738)2.28014178
68Postaxial hand polydactyly (HP:0001162)2.26984117
69Diplopia (HP:0000651)2.26019726
70Abnormality of binocular vision (HP:0011514)2.26019726
71Medial flaring of the eyebrow (HP:0010747)2.23735068
72Aplasia involving bones of the upper limbs (HP:0009823)2.22672971
73Aplasia of the phalanges of the hand (HP:0009802)2.22672971
74Aplasia involving bones of the extremities (HP:0009825)2.22672971
75Inability to walk (HP:0002540)2.22628802
76Intestinal atresia (HP:0011100)2.22493989
77Gaze-evoked nystagmus (HP:0000640)2.21493632
78Abnormality of the lower motor neuron (HP:0002366)2.20629796
79Chronic hepatic failure (HP:0100626)2.19719660
80Inappropriate behavior (HP:0000719)2.19258628
81* Abnormal social behavior (HP:0012433)2.19001197
82* Impaired social interactions (HP:0000735)2.19001197
83Lissencephaly (HP:0001339)2.17766092
84Dysdiadochokinesis (HP:0002075)2.16559558
85Renal dysplasia (HP:0000110)2.16189992
86Insidious onset (HP:0003587)2.16147962
87Termporal pattern (HP:0011008)2.16147962
88Papilledema (HP:0001085)2.16120586
89Truncal ataxia (HP:0002078)2.15886520
90Congenital primary aphakia (HP:0007707)2.14605832
91Sclerocornea (HP:0000647)2.14209075
92Protruding tongue (HP:0010808)2.12343750
93Volvulus (HP:0002580)2.12023290
94Insomnia (HP:0100785)2.11718865
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11487608
96Abnormality of the corticospinal tract (HP:0002492)2.11156040
97Dysmetria (HP:0001310)2.09988936
98Bronchomalacia (HP:0002780)2.09833735
99Vitreoretinal degeneration (HP:0000655)2.09251514
100Focal dystonia (HP:0004373)2.08212802
101Morphological abnormality of the inner ear (HP:0011390)2.07523929
102Sleep apnea (HP:0010535)2.07189204
103Anophthalmia (HP:0000528)2.07107878
104Lower limb amyotrophy (HP:0007210)2.06887943
105Shallow orbits (HP:0000586)2.06729999
106Nephrogenic diabetes insipidus (HP:0009806)2.06691460
107Adrenal hypoplasia (HP:0000835)2.06197780
108Pointed chin (HP:0000307)2.03078552
109High anterior hairline (HP:0009890)2.02949625
110Torticollis (HP:0000473)2.02453369
111Narrow forehead (HP:0000341)2.00271062
112Retinal dysplasia (HP:0007973)1.98701560
113Fetal akinesia sequence (HP:0001989)1.97442179
114Astrocytoma (HP:0009592)1.95909890
115Abnormality of the astrocytes (HP:0100707)1.95909890
116Preaxial hand polydactyly (HP:0001177)1.95721693
117Large eyes (HP:0001090)1.95497986
118Sporadic (HP:0003745)1.93671427
119* Autism (HP:0000717)1.93494160
120Urinary urgency (HP:0000012)1.93325251
121Cortical dysplasia (HP:0002539)1.93214667
122Morphological abnormality of the middle ear (HP:0008609)1.92415649
123Apathy (HP:0000741)1.92318516
124Hemivertebrae (HP:0002937)1.91671877
125Specific learning disability (HP:0001328)1.90948214
126Aqueductal stenosis (HP:0002410)1.90816206
127Gastrointestinal atresia (HP:0002589)1.88987456
128Spastic gait (HP:0002064)1.88884029
129Anencephaly (HP:0002323)1.87694365
130* Pachygyria (HP:0001302)1.87554970
131Genital tract atresia (HP:0001827)1.86956608
132Exotropia (HP:0000577)1.85918371
133Patellar aplasia (HP:0006443)1.85842818
134Widely spaced teeth (HP:0000687)1.85221753
135Cystic liver disease (HP:0006706)1.84760073
136Deeply set eye (HP:0000490)1.84655269
137Thyroid-stimulating hormone excess (HP:0002925)1.84573050
138Lower limb muscle weakness (HP:0007340)1.84477983
139Generalized myoclonic seizures (HP:0002123)1.84358812
140Postural instability (HP:0002172)1.83776862
141* Abnormality of salivation (HP:0100755)1.82722874
142Impaired smooth pursuit (HP:0007772)1.82225163
143Cutaneous finger syndactyly (HP:0010554)1.81768204
144Growth hormone deficiency (HP:0000824)1.81301068
145Bradykinesia (HP:0002067)1.80639945
146Cutaneous syndactyly (HP:0012725)1.80092074
147Microglossia (HP:0000171)1.79678332
148Preaxial foot polydactyly (HP:0001841)1.79215679
149Micropenis (HP:0000054)1.79000587
15011 pairs of ribs (HP:0000878)1.78922989
151Blue irides (HP:0000635)1.77696247
152Esophageal atresia (HP:0002032)1.77584499
153Lower limb asymmetry (HP:0100559)1.77531843
154Vaginal atresia (HP:0000148)1.76666248
155Polyphagia (HP:0002591)1.76582384
156Broad foot (HP:0001769)1.76560891
157Hypoplasia of the brainstem (HP:0002365)1.75558973
158Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75558973
159Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74683493
160Coronal craniosynostosis (HP:0004440)1.74594970
161Holoprosencephaly (HP:0001360)1.74071704
162* Gastroesophageal reflux (HP:0002020)1.73899399
163Open mouth (HP:0000194)1.73015665
164Glioma (HP:0009733)1.72754718
165Absent septum pellucidum (HP:0001331)1.72686757
166Type II lissencephaly (HP:0007260)1.72575845
167Annular pancreas (HP:0001734)1.72065412
168Hepatoblastoma (HP:0002884)1.71953666
169Aplasia/Hypoplasia of the patella (HP:0006498)1.71644324
170Hypoplastic ischia (HP:0003175)1.71153365
171Supernumerary spleens (HP:0009799)1.70266106
172Split foot (HP:0001839)1.69700925
173Abnormality of the intervertebral disk (HP:0005108)1.68725078
174Intellectual disability, moderate (HP:0002342)1.68401283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.57475464
2MARK14.86328909
3NTRK33.99135207
4MAP4K23.51916001
5MAP3K42.79079081
6MAP3K92.73675176
7MAP2K72.59879168
8WNK32.56963238
9CASK2.40819266
10SIK22.39575166
11PRKD32.34215015
12DAPK22.24506790
13MINK12.20170211
14PAK62.10961487
15NTRK22.06639982
16TRIM281.88241952
17KSR11.84761855
18MAPK131.83658662
19RIPK41.83210187
20EPHB21.78194039
21PLK21.73178094
22FRK1.72846121
23PRPF4B1.59605546
24NUAK11.55465945
25PNCK1.52049603
26WEE11.51177795
27CDK51.50782458
28MAP2K41.48643828
29CAMKK11.42173772
30LATS21.40043080
31CCNB11.39457884
32KSR21.37447035
33TNIK1.36900184
34DAPK11.31786748
35CSNK1G31.24866633
36NTRK11.20483223
37BRSK21.19669500
38PINK11.16109526
39PRKCG1.11211652
40CSNK1G11.11074992
41MAP3K121.10734927
42PHKG11.09221406
43PHKG21.09221406
44MKNK11.08404047
45UHMK11.05583953
46TYRO31.05402362
47FES1.05341102
48BMPR21.01947281
49GRK51.01364835
50DYRK21.00221168
51PLK40.98321199
52MAPK150.97541347
53CAMK2A0.94553559
54CDK180.89527793
55DYRK1A0.88718764
56CDK150.88652639
57CDC70.87827915
58PTK2B0.86424046
59FGR0.86333872
60MARK20.85888808
61STK110.85519442
62MAP3K20.84626653
63CAMK2B0.84393683
64BRSK10.84371167
65DYRK30.84344791
66CDK140.84043582
67ERBB30.79765440
68CDK11A0.78028802
69CSNK1G20.77267533
70EPHA30.76060147
71CDK190.75579448
72SGK4940.73527334
73SGK2230.73527334
74BMPR1B0.73063815
75PRKCZ0.71416213
76TAOK10.68117572
77SGK20.67523492
78CAMK10.67281793
79PKN10.65216294
80SGK10.65128868
81RAF10.64168849
82SRPK10.63141530
83PAK30.61277960
84FER0.61146337
85PIK3CA0.60984863
86PRKCH0.60556344
87STK380.59955287
88PRKCE0.59004465
89CAMK1G0.58356301
90MAP3K60.58252665
91CAMK1D0.55835473
92NME10.55658821
93ERBB20.55639038
94INSRR0.55218315
95DMPK0.54469555
96ARAF0.52490571
97VRK10.51143445
98YES10.48608682
99PLK30.48264914
100CDK30.48250135
101SGK30.47668450
102ATR0.47506501
103ROCK20.47482668
104PRKD20.46747767
105MAP3K130.46543009
106FGFR20.46536206
107RPS6KA20.46351019
108PLK10.45956216
109RET0.44687192
110DDR20.44273261
111FYN0.42983037
112DYRK1B0.42564925
113LATS10.42084403
114CSNK1D0.40363817
115WNK40.39504667
116RPS6KA40.39149952
117RPS6KA30.39140702
118PRKDC0.38053082
119ALK0.37942256
120GRK10.36426316
121* CSNK1A10.35703323
122MAP2K10.35556941
123ATM0.35281098
124CAMK2D0.35265304
125AKT30.34323519
126BCR0.32286115
127MAPK100.32211121
128MKNK20.31904535
129CAMKK20.31227214
130CAMK40.30903137
131MAPK120.30373645
132TAOK20.29194041
133CSNK1A1L0.28576235
134MAPK90.27978019
135ROCK10.27927019
136OXSR10.27738179
137PRKCB0.27711483

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65512582
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69874161
3Circadian entrainment_Homo sapiens_hsa047132.69070240
4Glutamatergic synapse_Homo sapiens_hsa047242.68264670
5Long-term potentiation_Homo sapiens_hsa047202.67184494
6Olfactory transduction_Homo sapiens_hsa047402.57755504
7GABAergic synapse_Homo sapiens_hsa047272.52977995
8Morphine addiction_Homo sapiens_hsa050322.52002551
9Synaptic vesicle cycle_Homo sapiens_hsa047212.51906832
10Amphetamine addiction_Homo sapiens_hsa050312.38062787
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30250576
12Dopaminergic synapse_Homo sapiens_hsa047282.22009726
13Salivary secretion_Homo sapiens_hsa049702.06094425
14Axon guidance_Homo sapiens_hsa043601.95036504
15Steroid biosynthesis_Homo sapiens_hsa001001.94439240
16Cholinergic synapse_Homo sapiens_hsa047251.92182153
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90555219
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87020188
19Serotonergic synapse_Homo sapiens_hsa047261.85856912
20Long-term depression_Homo sapiens_hsa047301.80024929
21Taste transduction_Homo sapiens_hsa047421.78519747
22Gastric acid secretion_Homo sapiens_hsa049711.77211730
23Renin secretion_Homo sapiens_hsa049241.75838140
24Fanconi anemia pathway_Homo sapiens_hsa034601.74319596
25Oxytocin signaling pathway_Homo sapiens_hsa049211.71475862
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71266687
27Insulin secretion_Homo sapiens_hsa049111.70091932
28Cocaine addiction_Homo sapiens_hsa050301.67530477
29Calcium signaling pathway_Homo sapiens_hsa040201.55237658
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52455650
31GnRH signaling pathway_Homo sapiens_hsa049121.50563555
32Gap junction_Homo sapiens_hsa045401.50077179
33Butanoate metabolism_Homo sapiens_hsa006501.41684051
34Glioma_Homo sapiens_hsa052141.35953569
35Melanogenesis_Homo sapiens_hsa049161.29662423
36ErbB signaling pathway_Homo sapiens_hsa040121.28056783
37cAMP signaling pathway_Homo sapiens_hsa040241.26965903
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22790630
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22591989
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22004309
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21893807
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18993645
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18794793
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18374395
45Propanoate metabolism_Homo sapiens_hsa006401.17874108
46Estrogen signaling pathway_Homo sapiens_hsa049151.16683359
47Basal transcription factors_Homo sapiens_hsa030221.10934615
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07971704
49Homologous recombination_Homo sapiens_hsa034401.04699997
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01838069
51Phototransduction_Homo sapiens_hsa047440.99512450
52Collecting duct acid secretion_Homo sapiens_hsa049660.98906760
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98768972
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96781874
55Type II diabetes mellitus_Homo sapiens_hsa049300.96479709
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94399549
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93293508
58Dorso-ventral axis formation_Homo sapiens_hsa043200.90779480
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90614764
60Wnt signaling pathway_Homo sapiens_hsa043100.90514062
61Vitamin B6 metabolism_Homo sapiens_hsa007500.90142681
62Choline metabolism in cancer_Homo sapiens_hsa052310.88034113
63Protein export_Homo sapiens_hsa030600.86012888
64Non-homologous end-joining_Homo sapiens_hsa034500.85456563
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.84565984
66MAPK signaling pathway_Homo sapiens_hsa040100.83518927
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.83326279
68Notch signaling pathway_Homo sapiens_hsa043300.82691905
69VEGF signaling pathway_Homo sapiens_hsa043700.81052487
70Rap1 signaling pathway_Homo sapiens_hsa040150.79122669
71Endometrial cancer_Homo sapiens_hsa052130.78452889
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77523201
73beta-Alanine metabolism_Homo sapiens_hsa004100.77109593
74Ras signaling pathway_Homo sapiens_hsa040140.76675212
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.75354660
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74678149
77Oocyte meiosis_Homo sapiens_hsa041140.73744597
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72774273
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72618126
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70112767
81Lysine degradation_Homo sapiens_hsa003100.69363441
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69248281
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69205160
84Cardiac muscle contraction_Homo sapiens_hsa042600.69165405
85Colorectal cancer_Homo sapiens_hsa052100.66589361
86Cell cycle_Homo sapiens_hsa041100.65454454
87Spliceosome_Homo sapiens_hsa030400.65439221
88Dilated cardiomyopathy_Homo sapiens_hsa054140.65280200
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65156841
90Renal cell carcinoma_Homo sapiens_hsa052110.64567741
91RNA degradation_Homo sapiens_hsa030180.63897602
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.62964575
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62287720
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62188683
95mRNA surveillance pathway_Homo sapiens_hsa030150.62140799
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60624179
97Pancreatic secretion_Homo sapiens_hsa049720.60073880
98Linoleic acid metabolism_Homo sapiens_hsa005910.59929177
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59800895
100Peroxisome_Homo sapiens_hsa041460.59005890
101Alcoholism_Homo sapiens_hsa050340.57726438
102Non-small cell lung cancer_Homo sapiens_hsa052230.57062182
103African trypanosomiasis_Homo sapiens_hsa051430.55311126
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54665573
105Hedgehog signaling pathway_Homo sapiens_hsa043400.54051074
106Thyroid hormone synthesis_Homo sapiens_hsa049180.53838549
107Prion diseases_Homo sapiens_hsa050200.53019427
108Ether lipid metabolism_Homo sapiens_hsa005650.52969291
109Vibrio cholerae infection_Homo sapiens_hsa051100.52710643
110Regulation of autophagy_Homo sapiens_hsa041400.51985846
111Hippo signaling pathway_Homo sapiens_hsa043900.51336715
112Fatty acid metabolism_Homo sapiens_hsa012120.50371916
113Tryptophan metabolism_Homo sapiens_hsa003800.50230654
114Basal cell carcinoma_Homo sapiens_hsa052170.50045786
115Nitrogen metabolism_Homo sapiens_hsa009100.49839809
116Mismatch repair_Homo sapiens_hsa034300.49341261
117Glycerolipid metabolism_Homo sapiens_hsa005610.48912768
118mTOR signaling pathway_Homo sapiens_hsa041500.47505360
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47341774
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47333358
121Glucagon signaling pathway_Homo sapiens_hsa049220.47044030
122Melanoma_Homo sapiens_hsa052180.46319090
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44592223
124Arginine and proline metabolism_Homo sapiens_hsa003300.44305896
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42882273
126MicroRNAs in cancer_Homo sapiens_hsa052060.42353012
127Fatty acid elongation_Homo sapiens_hsa000620.41982663
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41406086
129AMPK signaling pathway_Homo sapiens_hsa041520.41232222
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40518187
131Endocytosis_Homo sapiens_hsa041440.40122914
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39791168
133Chemokine signaling pathway_Homo sapiens_hsa040620.38731160
134Type I diabetes mellitus_Homo sapiens_hsa049400.37928738
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36409347
136Insulin signaling pathway_Homo sapiens_hsa049100.35791564
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35554538
138Tight junction_Homo sapiens_hsa045300.35064929
139Circadian rhythm_Homo sapiens_hsa047100.34946722
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34705255
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32597476

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