FOXH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.55320284
2regulation of gene silencing by miRNA (GO:0060964)5.55320284
3regulation of gene silencing by RNA (GO:0060966)5.55320284
4formation of translation preinitiation complex (GO:0001731)4.86505752
5L-serine metabolic process (GO:0006563)4.85325786
6negative regulation of telomerase activity (GO:0051974)4.85304218
7proline biosynthetic process (GO:0006561)4.73846692
8DNA strand elongation involved in DNA replication (GO:0006271)4.49345289
9somatic diversification of immune receptors via somatic mutation (GO:0002566)4.37612546
10somatic hypermutation of immunoglobulin genes (GO:0016446)4.37612546
11DNA deamination (GO:0045006)4.30591290
12telomere maintenance via semi-conservative replication (GO:0032201)4.27509298
13DNA strand elongation (GO:0022616)4.24189146
14DNA damage response, detection of DNA damage (GO:0042769)4.13992352
15DNA unwinding involved in DNA replication (GO:0006268)4.08622604
16DNA replication initiation (GO:0006270)4.07458698
17transcription from mitochondrial promoter (GO:0006390)4.06652715
18cell migration involved in gastrulation (GO:0042074)4.06157642
19regulation of telomere maintenance via telomerase (GO:0032210)3.96689610
20replication fork processing (GO:0031297)3.92427768
21pre-miRNA processing (GO:0031054)3.89596726
22folic acid-containing compound biosynthetic process (GO:0009396)3.87749079
23ribosome biogenesis (GO:0042254)3.85906582
24DNA replication-dependent nucleosome assembly (GO:0006335)3.82711669
25DNA replication-dependent nucleosome organization (GO:0034723)3.82711669
26regulation of translational fidelity (GO:0006450)3.77200432
27maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.76159305
28embryonic process involved in female pregnancy (GO:0060136)3.76012662
29L-alpha-amino acid transmembrane transport (GO:1902475)3.74283365
30mitotic nuclear envelope disassembly (GO:0007077)3.74108886
31histone arginine methylation (GO:0034969)3.73081537
32nucleobase biosynthetic process (GO:0046112)3.65593267
33viral mRNA export from host cell nucleus (GO:0046784)3.64070428
34telomere maintenance via recombination (GO:0000722)3.63751839
35negative regulation of gene silencing (GO:0060969)3.59335094
36paraxial mesoderm development (GO:0048339)3.58744082
37mitotic metaphase plate congression (GO:0007080)3.58404763
38mitochondrial DNA metabolic process (GO:0032042)3.58333972
39mitotic sister chromatid segregation (GO:0000070)3.55193718
40negative regulation of telomere maintenance (GO:0032205)3.54667593
41positive regulation of SMAD protein import into nucleus (GO:0060391)3.54415972
42establishment of integrated proviral latency (GO:0075713)3.54305422
43histone H4-K12 acetylation (GO:0043983)3.54080669
44regulation of cell fate specification (GO:0042659)3.51230702
45maturation of SSU-rRNA (GO:0030490)3.50737510
46anterior/posterior axis specification, embryo (GO:0008595)3.50604737
47establishment of apical/basal cell polarity (GO:0035089)3.49479526
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.49269963
49protein localization to kinetochore (GO:0034501)3.47563364
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47402335
51DNA replication checkpoint (GO:0000076)3.45127797
52telomere maintenance via telomere lengthening (GO:0010833)3.45119415
53nuclear pore organization (GO:0006999)3.44501078
54nuclear envelope disassembly (GO:0051081)3.44389787
55membrane disassembly (GO:0030397)3.44389787
56proline metabolic process (GO:0006560)3.39674896
57IMP biosynthetic process (GO:0006188)3.39237571
58ribonucleoprotein complex biogenesis (GO:0022613)3.39047065
59mitotic recombination (GO:0006312)3.36500579
60telomere maintenance via telomerase (GO:0007004)3.36253539
61chromatin remodeling at centromere (GO:0031055)3.35843463
62pseudouridine synthesis (GO:0001522)3.34602288
63spliceosomal snRNP assembly (GO:0000387)3.32109147
64regulation of telomerase activity (GO:0051972)3.31620123
65chaperone-mediated protein transport (GO:0072321)3.30862775
66DNA strand renaturation (GO:0000733)3.29162509
67peptidyl-arginine omega-N-methylation (GO:0035247)3.28977669
68heterochromatin organization (GO:0070828)3.28564716
69regulation of double-strand break repair via homologous recombination (GO:0010569)3.26373305
70base-excision repair (GO:0006284)3.26366107
71serine family amino acid biosynthetic process (GO:0009070)3.24483074
72regulation of translation, ncRNA-mediated (GO:0045974)3.24359265
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.24359265
74negative regulation of translation, ncRNA-mediated (GO:0040033)3.24359265
75purine nucleobase biosynthetic process (GO:0009113)3.22968913
76DNA duplex unwinding (GO:0032508)3.19131398
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.18957530
78ribosome assembly (GO:0042255)3.18370597
79DNA geometric change (GO:0032392)3.18011517
80inner ear receptor cell development (GO:0060119)3.17357777
81establishment of protein localization to mitochondrial membrane (GO:0090151)3.16859617
82regulation of mesoderm development (GO:2000380)3.16724170
83regulation of helicase activity (GO:0051095)3.16208380
84positive regulation of chromosome segregation (GO:0051984)3.15985752
85CENP-A containing nucleosome assembly (GO:0034080)3.14170594
86kinetochore assembly (GO:0051382)3.13881428
87mitotic G1 DNA damage checkpoint (GO:0031571)3.10664741
88rRNA processing (GO:0006364)3.10493004
89regulation of sister chromatid cohesion (GO:0007063)3.10149375
90negative regulation of DNA biosynthetic process (GO:2000279)3.07363922
91positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.06778781
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.06778781
93positive regulation of mitotic sister chromatid separation (GO:1901970)3.06778781
94translational initiation (GO:0006413)3.06718893
95cell fate commitment involved in formation of primary germ layer (GO:0060795)3.06353390
96termination of RNA polymerase II transcription (GO:0006369)3.04424450
97viral transcription (GO:0019083)3.04226752
98lung-associated mesenchyme development (GO:0060484)3.03717838
99cullin deneddylation (GO:0010388)3.01178456
100protein complex localization (GO:0031503)3.01061709
101behavioral response to nicotine (GO:0035095)3.00407224
102maturation of 5.8S rRNA (GO:0000460)2.99994151
103metaphase plate congression (GO:0051310)2.99589619
104rRNA metabolic process (GO:0016072)2.98968965
105kinetochore organization (GO:0051383)2.98232314
106ribosomal large subunit biogenesis (GO:0042273)2.96785163
107translational termination (GO:0006415)2.96273805
108mitochondrial RNA metabolic process (GO:0000959)2.96110496
109nuclear pore complex assembly (GO:0051292)2.95855810
110regulation of nuclear cell cycle DNA replication (GO:0033262)2.95418364
111regulation of gene silencing (GO:0060968)2.94571532
112establishment of monopolar cell polarity (GO:0061162)2.94455832
113establishment or maintenance of monopolar cell polarity (GO:0061339)2.94455832
114trophectodermal cell differentiation (GO:0001829)2.94405870
115sister chromatid segregation (GO:0000819)2.93117301
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93068078
117spliceosomal tri-snRNP complex assembly (GO:0000244)2.92455629
118regulation of cell fate commitment (GO:0010453)2.91516361
119ribosomal small subunit biogenesis (GO:0042274)2.90141314
120neurofilament cytoskeleton organization (GO:0060052)2.89257422
121negative regulation of chromosome segregation (GO:0051985)2.88231506
122regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.87902102
123folic acid metabolic process (GO:0046655)2.86880317
124mRNA cleavage (GO:0006379)2.85456408
125histone exchange (GO:0043486)2.85303379
126energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84839417
127ATP synthesis coupled proton transport (GO:0015986)2.84839417
128regulation of telomere maintenance (GO:0032204)2.84807032
129DNA replication-independent nucleosome organization (GO:0034724)2.84708668
130DNA replication-independent nucleosome assembly (GO:0006336)2.84708668
131regulation of centrosome cycle (GO:0046605)2.84515871
132transcription-coupled nucleotide-excision repair (GO:0006283)2.84379120
133regulation of SMAD protein import into nucleus (GO:0060390)2.74794685
134regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.71259252
135regulation of mitotic spindle checkpoint (GO:1903504)2.71259252
136mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.70217183
137female gonad development (GO:0008585)2.69919777
138presynaptic membrane assembly (GO:0097105)2.66711283
139homocysteine metabolic process (GO:0050667)2.63843972
140serine family amino acid catabolic process (GO:0009071)2.63594274
141termination of RNA polymerase III transcription (GO:0006386)2.62908889
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.62908889
143mesenchymal to epithelial transition (GO:0060231)2.61303808
144regulation of DNA methylation (GO:0044030)2.60640827
145ribosomal small subunit assembly (GO:0000028)2.60480757
146mitochondrial respiratory chain complex I assembly (GO:0032981)2.59995193
147NADH dehydrogenase complex assembly (GO:0010257)2.59995193
148mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59995193
149regulation of stem cell maintenance (GO:2000036)2.52358325
150protein complex biogenesis (GO:0070271)2.51861916
151mitochondrial respiratory chain complex assembly (GO:0033108)2.51643501
152RNA-dependent DNA replication (GO:0006278)2.51109607
153DNA damage induced protein phosphorylation (GO:0006975)2.50738573
154regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.49096038
155respiratory electron transport chain (GO:0022904)2.47721854
156water-soluble vitamin biosynthetic process (GO:0042364)2.47614569
157otic vesicle formation (GO:0030916)2.47008665
158establishment of viral latency (GO:0019043)2.45731422
159convergent extension (GO:0060026)2.44232165
160electron transport chain (GO:0022900)2.43214570
161neuron cell-cell adhesion (GO:0007158)2.42451593
162negative regulation of DNA-dependent DNA replication (GO:2000104)2.42423199
163regulation of timing of cell differentiation (GO:0048505)2.41245798
164protein-cofactor linkage (GO:0018065)2.40529072
165cell migration in hindbrain (GO:0021535)2.35739165
166regulation of mitochondrial translation (GO:0070129)2.35437440
167atrial cardiac muscle cell action potential (GO:0086014)2.33921693
168primitive streak formation (GO:0090009)2.33407891
169ATP-dependent chromatin remodeling (GO:0043044)2.32678667
170regulation of development, heterochronic (GO:0040034)2.30098014
171presynaptic membrane organization (GO:0097090)2.29414451
172rRNA modification (GO:0000154)2.29122465
173ncRNA catabolic process (GO:0034661)2.28745149
174kidney morphogenesis (GO:0060993)2.28339750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.74143466
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.30781405
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.42530414
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36717489
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.31388624
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.09835756
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.01226432
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.01226432
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.01226432
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91914635
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84673489
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83506273
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.79283921
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.77570775
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62228373
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.57235223
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55188323
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.54215997
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34891909
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.33609320
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.33555118
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.28080847
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27153326
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24562131
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21251260
26* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18137469
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15552011
28SOX2_16153702_ChIP-ChIP_HESCs_Human2.12987586
29POU5F1_16153702_ChIP-ChIP_HESCs_Human2.12210061
30TCF3_18692474_ChIP-Seq_MEFs_Mouse2.11150110
31* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.09810467
32EZH2_22144423_ChIP-Seq_EOC_Human2.09722286
33XRN2_22483619_ChIP-Seq_HELA_Human2.09418994
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07484760
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02169177
36CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01279209
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97071080
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.97051989
39* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.94944130
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.93564120
41TCF3_18692474_ChIP-Seq_MESCs_Mouse1.90662977
42SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.84856411
43* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83628032
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83517333
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83190616
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79847155
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79454861
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.77757653
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.76599743
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.74079922
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.72791175
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.72629835
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71234326
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.68303888
55TTF2_22483619_ChIP-Seq_HELA_Human1.66401470
56* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.63543148
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.61044883
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58547129
59ZNF274_21170338_ChIP-Seq_K562_Hela1.58024769
60DCP1A_22483619_ChIP-Seq_HELA_Human1.57099755
61MYC_18940864_ChIP-ChIP_HL60_Human1.56935008
62NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.54789052
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54252301
64* GABP_19822575_ChIP-Seq_HepG2_Human1.53579075
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52884994
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.52232090
67VDR_23849224_ChIP-Seq_CD4+_Human1.50365049
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50087454
69* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.49149568
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.47701316
71AR_21909140_ChIP-Seq_LNCAP_Human1.44279765
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43500838
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.42933985
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42300883
75SOX2_18692474_ChIP-Seq_MEFs_Mouse1.42247676
76VDR_22108803_ChIP-Seq_LS180_Human1.41078037
77* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40356594
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39037099
79REST_21632747_ChIP-Seq_MESCs_Mouse1.37600120
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35045120
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34418762
82* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32927018
83MYC_22102868_ChIP-Seq_BL_Human1.32877498
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32376481
85* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31848308
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31312740
87FOXP3_21729870_ChIP-Seq_TREG_Human1.31168524
88* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30192707
89SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28147621
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26018629
91* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.25178232
92* KDM5A_27292631_Chip-Seq_BREAST_Human1.21923248
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19576911
94NANOG_18692474_ChIP-Seq_MEFs_Mouse1.17073176
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16678472
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15048799
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12456181
98NANOG_18692474_ChIP-Seq_MESCs_Mouse1.11229068
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10315610
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10284784
101* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09309865
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.08084301
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07884404
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07884404
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07735471
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07591943
107EGR1_19374776_ChIP-ChIP_THP-1_Human1.07159539
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06849294
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05642720
110TFEB_21752829_ChIP-Seq_HELA_Human1.05459506
111* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04328235
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04150655
113EWS_26573619_Chip-Seq_HEK293_Human1.04036658
114PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01389898
115FUS_26573619_Chip-Seq_HEK293_Human1.01385917
116REST_18959480_ChIP-ChIP_MESCs_Mouse1.00413151
117GBX2_23144817_ChIP-Seq_PC3_Human1.00158195
118* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99675908
119CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99403588
120CIITA_25753668_ChIP-Seq_RAJI_Human0.99018851
121TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98881444
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98365337
123TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98143489
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97853832
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97482642
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.95654732
127RNF2_27304074_Chip-Seq_NSC_Mouse0.95281802
128* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95144012
129P300_19829295_ChIP-Seq_ESCs_Human0.94316210
130SRF_21415370_ChIP-Seq_HL-1_Mouse0.93635212
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93375385
132EZH2_27304074_Chip-Seq_ESCs_Mouse0.92646064
133* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92275750
134* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91608522
135VDR_21846776_ChIP-Seq_THP-1_Human0.91275541
136ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90620360
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90348319
138* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90257439
139ELK1_19687146_ChIP-ChIP_HELA_Human0.88304616
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87837090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.86996822
2MP0004957_abnormal_blastocyst_morpholog4.13415583
3MP0003693_abnormal_embryo_hatching3.85714232
4MP0010094_abnormal_chromosome_stability3.79014938
5MP0003111_abnormal_nucleus_morphology3.57489374
6MP0010030_abnormal_orbit_morphology3.51581360
7MP0003077_abnormal_cell_cycle3.28819039
8MP0008932_abnormal_embryonic_tissue2.87695391
9MP0008058_abnormal_DNA_repair2.85745517
10MP0003119_abnormal_digestive_system2.71862027
11MP0002653_abnormal_ependyma_morphology2.55414092
12* MP0004133_heterotaxia2.54097796
13* MP0003890_abnormal_embryonic-extraembry2.51876466
14MP0003787_abnormal_imprinting2.51855498
15MP0001730_embryonic_growth_arrest2.49733738
16MP0010352_gastrointestinal_tract_polyps2.43796790
17MP0003123_paternal_imprinting2.32399609
18MP0003806_abnormal_nucleotide_metabolis2.20942635
19MP0008877_abnormal_DNA_methylation2.20570522
20MP0001188_hyperpigmentation2.14529770
21* MP0005380_embryogenesis_phenotype2.12206363
22* MP0001672_abnormal_embryogenesis/_devel2.12206363
23* MP0002084_abnormal_developmental_patter2.11244654
24MP0000350_abnormal_cell_proliferation2.08887059
25* MP0002085_abnormal_embryonic_tissue2.01977139
26* MP0001697_abnormal_embryo_size1.98603319
27MP0001293_anophthalmia1.90673770
28MP0003283_abnormal_digestive_organ1.84281475
29MP0009379_abnormal_foot_pigmentation1.82892428
30MP0002086_abnormal_extraembryonic_tissu1.80909686
31MP0008007_abnormal_cellular_replicative1.80698872
32MP0004197_abnormal_fetal_growth/weight/1.80256619
33MP0002736_abnormal_nociception_after1.77319369
34* MP0003984_embryonic_growth_retardation1.75461618
35MP0003786_premature_aging1.73859894
36MP0000566_synostosis1.73244939
37* MP0002088_abnormal_embryonic_growth/wei1.72530759
38MP0003122_maternal_imprinting1.71979395
39MP0006292_abnormal_olfactory_placode1.69260143
40MP0009672_abnormal_birth_weight1.66995322
41* MP0002080_prenatal_lethality1.61051885
42MP0002163_abnormal_gland_morphology1.55724671
43MP0004270_analgesia1.55151048
44MP0002111_abnormal_tail_morphology1.51099601
45MP0001968_abnormal_touch/_nociception1.48920311
46MP0004233_abnormal_muscle_weight1.47322043
47MP0003567_abnormal_fetal_cardiomyocyte1.45241734
48MP0001485_abnormal_pinna_reflex1.41669855
49MP0003718_maternal_effect1.41496575
50MP0001984_abnormal_olfaction1.41338596
51MP0002938_white_spotting1.40276464
52MP0003938_abnormal_ear_development1.36408255
53MP0003941_abnormal_skin_development1.32105490
54MP0000778_abnormal_nervous_system1.31704562
55MP0002249_abnormal_larynx_morphology1.31312636
56MP0000631_abnormal_neuroendocrine_gland1.29806798
57MP0005377_hearing/vestibular/ear_phenot1.27292710
58MP0003878_abnormal_ear_physiology1.27292710
59MP0009745_abnormal_behavioral_response1.27097734
60MP0002734_abnormal_mechanical_nocicepti1.27001509
61MP0006276_abnormal_autonomic_nervous1.26023024
62MP0005076_abnormal_cell_differentiation1.25776016
63MP0009278_abnormal_bone_marrow1.23973530
64MP0004859_abnormal_synaptic_plasticity1.23482088
65MP0010307_abnormal_tumor_latency1.23480310
66MP0000313_abnormal_cell_death1.22507327
67MP0004885_abnormal_endolymph1.20864037
68MP0003121_genomic_imprinting1.16890580
69MP0000490_abnormal_crypts_of1.15827145
70MP0003635_abnormal_synaptic_transmissio1.15725080
71MP0002272_abnormal_nervous_system1.15694991
72MP0009053_abnormal_anal_canal1.13706571
73MP0001529_abnormal_vocalization1.11013592
74MP0005266_abnormal_metabolism1.10059645
75MP0005423_abnormal_somatic_nervous1.09787148
76MP0008995_early_reproductive_senescence1.09227149
77MP0000049_abnormal_middle_ear1.08619353
78MP0005551_abnormal_eye_electrophysiolog1.07478855
79MP0000678_abnormal_parathyroid_gland1.07012544
80MP0003937_abnormal_limbs/digits/tail_de1.05726822
81MP0006072_abnormal_retinal_apoptosis1.04564394
82MP0003880_abnormal_central_pattern1.04314763
83MP0002332_abnormal_exercise_endurance1.03558488
84MP0002233_abnormal_nose_morphology1.03389497
85MP0004264_abnormal_extraembryonic_tissu1.02574319
86MP0009046_muscle_twitch1.01377605
87MP0000955_abnormal_spinal_cord1.00871336
88MP0002932_abnormal_joint_morphology1.00422261
89MP0005379_endocrine/exocrine_gland_phen1.00294088
90MP0002160_abnormal_reproductive_system0.99430926
91MP0002751_abnormal_autonomic_nervous0.99219360
92MP0000537_abnormal_urethra_morphology0.99021855
93MP0005367_renal/urinary_system_phenotyp0.98688995
94MP0000516_abnormal_urinary_system0.98688995
95MP0002019_abnormal_tumor_incidence0.98629491
96MP0001145_abnormal_male_reproductive0.97584251
97* MP0000432_abnormal_head_morphology0.97418364
98MP0002735_abnormal_chemical_nociception0.96607355
99MP0001299_abnormal_eye_distance/0.96562369
100MP0002210_abnormal_sex_determination0.95362090
101MP0000647_abnormal_sebaceous_gland0.95138549
102MP0003315_abnormal_perineum_morphology0.94288728
103MP0002733_abnormal_thermal_nociception0.93083738
104MP0000579_abnormal_nail_morphology0.92799801
105MP0002064_seizures0.91976205
106MP0002269_muscular_atrophy0.91619300
107MP0003566_abnormal_cell_adhesion0.88871103
108* MP0003935_abnormal_craniofacial_develop0.88495944
109MP0000762_abnormal_tongue_morphology0.88415640
110* MP0002152_abnormal_brain_morphology0.87777559
111MP0002277_abnormal_respiratory_mucosa0.87278439
112MP0002184_abnormal_innervation0.86757298
113MP0002557_abnormal_social/conspecific_i0.86002994
114MP0001440_abnormal_grooming_behavior0.85738540
115* MP0003861_abnormal_nervous_system0.85590682
116MP0002572_abnormal_emotion/affect_behav0.85095073
117MP0002127_abnormal_cardiovascular_syste0.85038001
118MP0001919_abnormal_reproductive_system0.84573944
119MP0000428_abnormal_craniofacial_morphol0.84486559
120MP0005646_abnormal_pituitary_gland0.83401524
121MP0002063_abnormal_learning/memory/cond0.83358767
122MP0001286_abnormal_eye_development0.83210251
123MP0002752_abnormal_somatic_nervous0.82962339
124MP0002114_abnormal_axial_skeleton0.82647230
125MP0002090_abnormal_vision0.81847999
126MP0003755_abnormal_palate_morphology0.81595394
127MP0005501_abnormal_skin_physiology0.80158125
128MP0002697_abnormal_eye_size0.77735469
129MP0003936_abnormal_reproductive_system0.77431636
130MP0005171_absent_coat_pigmentation0.76774295
131MP0004142_abnormal_muscle_tone0.76231969
132MP0001545_abnormal_hematopoietic_system0.76102253
133MP0005397_hematopoietic_system_phenotyp0.76102253
134MP0001849_ear_inflammation0.74838834
135MP0009703_decreased_birth_body0.74518045
136MP0002092_abnormal_eye_morphology0.74033467
137MP0003705_abnormal_hypodermis_morpholog0.73514733
138MP0000358_abnormal_cell_content/0.73363292
139MP0005389_reproductive_system_phenotype0.72393630
140MP0000653_abnormal_sex_gland0.71881789
141MP0002116_abnormal_craniofacial_bone0.70086945
142MP0001929_abnormal_gametogenesis0.69028017
143MP0005499_abnormal_olfactory_system0.68573765
144MP0005394_taste/olfaction_phenotype0.68573765
145* MP0002925_abnormal_cardiovascular_devel0.68524333
146MP0003942_abnormal_urinary_system0.66555332
147MP0003136_yellow_coat_color0.65481739
148MP0002796_impaired_skin_barrier0.65246500
149MP0002254_reproductive_system_inflammat0.64748207
150MP0003186_abnormal_redox_activity0.64314732
151MP0005023_abnormal_wound_healing0.63785500
152MP0003385_abnormal_body_wall0.63067910
153MP0008789_abnormal_olfactory_epithelium0.62869171

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.41959431
2Absent radius (HP:0003974)4.19870662
3Aplasia/hypoplasia of the humerus (HP:0006507)3.94768830
4Aplasia involving forearm bones (HP:0009822)3.94635584
5Absent forearm bone (HP:0003953)3.94635584
6Rectal fistula (HP:0100590)3.93789268
7Rectovaginal fistula (HP:0000143)3.93789268
8Ependymoma (HP:0002888)3.83641561
9Short humerus (HP:0005792)3.70005469
10Breast hypoplasia (HP:0003187)3.63672578
11Selective tooth agenesis (HP:0001592)3.62106827
12Abnormality of abdominal situs (HP:0011620)3.55278433
13Abdominal situs inversus (HP:0003363)3.55278433
14Intestinal fistula (HP:0100819)3.51550050
15Supernumerary spleens (HP:0009799)3.48755392
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.46726089
17Birth length less than 3rd percentile (HP:0003561)3.40714593
18Absent thumb (HP:0009777)3.38653830
19Vaginal fistula (HP:0004320)3.37806779
20Colon cancer (HP:0003003)3.19529462
21Patellar aplasia (HP:0006443)3.16982579
22Abnormality of the labia minora (HP:0012880)3.11485791
23Maternal diabetes (HP:0009800)2.97521375
24Medulloblastoma (HP:0002885)2.96987770
25Absent septum pellucidum (HP:0001331)2.93196226
26Astrocytoma (HP:0009592)2.92737897
27Abnormality of the astrocytes (HP:0100707)2.92737897
28Hepatoblastoma (HP:0002884)2.91251502
29Aplasia/Hypoplasia of the patella (HP:0006498)2.87549439
30Abnormal number of incisors (HP:0011064)2.82922315
31Tongue fasciculations (HP:0001308)2.82561299
32Carpal bone hypoplasia (HP:0001498)2.81587234
33Vertebral fusion (HP:0002948)2.71404620
34Facial hemangioma (HP:0000329)2.69021734
35Hyperglycinemia (HP:0002154)2.68944996
36Concave nail (HP:0001598)2.67976356
37Limb dystonia (HP:0002451)2.65372401
38Intestinal atresia (HP:0011100)2.64068200
39Abnormality of the ileum (HP:0001549)2.62437508
40Reticulocytopenia (HP:0001896)2.62116687
41Rhabdomyosarcoma (HP:0002859)2.61228242
42Shawl scrotum (HP:0000049)2.60420910
43Asplenia (HP:0001746)2.60336416
44Neoplasm of the oral cavity (HP:0100649)2.58926507
45Hypochromic microcytic anemia (HP:0004840)2.58547281
46Trismus (HP:0000211)2.57754329
47Abnormality of homocysteine metabolism (HP:0010919)2.57332527
48Homocystinuria (HP:0002156)2.57332527
49Oral leukoplakia (HP:0002745)2.56179369
50Cerebral hypomyelination (HP:0006808)2.55117298
51Muscle fibrillation (HP:0010546)2.54230819
52Bilateral microphthalmos (HP:0007633)2.51324809
53Abnormality of the septum pellucidum (HP:0007375)2.49989884
54Choanal stenosis (HP:0000452)2.46774646
55Abnormality of the anterior horn cell (HP:0006802)2.46182878
56Degeneration of anterior horn cells (HP:0002398)2.46182878
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46169496
58Hemivertebrae (HP:0002937)2.43634503
59Hyperglycinuria (HP:0003108)2.43200048
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41645778
61Premature graying of hair (HP:0002216)2.41068911
62Chromsome breakage (HP:0040012)2.38918500
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.38765362
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.37748071
65Glioma (HP:0009733)2.37252397
66Basal cell carcinoma (HP:0002671)2.36850465
67Missing ribs (HP:0000921)2.35633171
68Hypoplasia of the radius (HP:0002984)2.31016431
69Rough bone trabeculation (HP:0100670)2.28516634
70Abnormality of cells of the erythroid lineage (HP:0012130)2.28040097
71Agnosia (HP:0010524)2.27568685
72Meckel diverticulum (HP:0002245)2.27243825
73Premature ovarian failure (HP:0008209)2.26988975
74Multiple enchondromatosis (HP:0005701)2.26905438
75Neoplasm of striated muscle (HP:0009728)2.26411448
76Myokymia (HP:0002411)2.25452697
77Acute necrotizing encephalopathy (HP:0006965)2.24826910
78Optic nerve hypoplasia (HP:0000609)2.24690330
79Squamous cell carcinoma (HP:0002860)2.24399690
80Impulsivity (HP:0100710)2.22954761
81Spinal muscular atrophy (HP:0007269)2.20327948
82Annular pancreas (HP:0001734)2.19408973
83Fused cervical vertebrae (HP:0002949)2.16249721
84Poor suck (HP:0002033)2.13109120
85Abnormality of glycine metabolism (HP:0010895)2.11828428
86Abnormality of serine family amino acid metabolism (HP:0010894)2.11828428
87Preauricular skin tag (HP:0000384)2.11302167
88Aplasia/Hypoplasia of the uvula (HP:0010293)2.11106940
89Abnormal hemoglobin (HP:0011902)2.10451104
90Short hallux (HP:0010109)2.09968802
91Aqueductal stenosis (HP:0002410)2.09771821
92Acute encephalopathy (HP:0006846)2.09305302
93Breast aplasia (HP:0100783)2.07975924
94Cortical dysplasia (HP:0002539)2.07961596
95Hypogonadotrophic hypogonadism (HP:0000044)2.07336273
96Orthostatic hypotension (HP:0001278)2.06666570
97Partial duplication of thumb phalanx (HP:0009944)2.06531719
98Synostosis involving the elbow (HP:0003938)2.03995516
99Humeroradial synostosis (HP:0003041)2.03995516
100Horseshoe kidney (HP:0000085)2.03306079
101Tracheoesophageal fistula (HP:0002575)2.03260190
102Hypoplastic female external genitalia (HP:0012815)2.02345876
103Abnormal number of erythroid precursors (HP:0012131)2.00697473
104Stenosis of the external auditory canal (HP:0000402)1.99310014
105Molar tooth sign on MRI (HP:0002419)1.98723430
106Abnormality of midbrain morphology (HP:0002418)1.98723430
107Abnormal lung lobation (HP:0002101)1.98100992
108Aplasia/Hypoplasia involving the musculature (HP:0001460)1.97612184
109Proximal placement of thumb (HP:0009623)1.97479931
110Gastrointestinal atresia (HP:0002589)1.97177015
111Abnormality of the lower motor neuron (HP:0002366)1.96634029
112Aplasia/Hypoplasia of the hallux (HP:0008362)1.95625585
113Nephronophthisis (HP:0000090)1.95280925
114Vertebral hypoplasia (HP:0008417)1.95071535
115Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.95071535
116Anal stenosis (HP:0002025)1.94778034
117Abnormality of serum amino acid levels (HP:0003112)1.94439763
118Aplasia/Hypoplasia of the breasts (HP:0010311)1.94189031
119Skin tags (HP:0010609)1.93941148
120Septo-optic dysplasia (HP:0100842)1.93507304
121Labial hypoplasia (HP:0000066)1.93409083
122Osteomalacia (HP:0002749)1.92218037
123Esophageal atresia (HP:0002032)1.92115816
124Turricephaly (HP:0000262)1.91753621
125Deviation of the thumb (HP:0009603)1.91709416
126Chronic bronchitis (HP:0004469)1.91676978
127Abnormal ventriculo-arterial connection (HP:0011563)1.91553484
128Transposition of the great arteries (HP:0001669)1.91553484
129Abnormal connection of the cardiac segments (HP:0011545)1.91553484
130Myelomeningocele (HP:0002475)1.90747926
131Macrocytic anemia (HP:0001972)1.90284288
132Broad alveolar ridges (HP:0000187)1.90210362
133Atresia of the external auditory canal (HP:0000413)1.89893407
134Short thumb (HP:0009778)1.89242104
135Pendular nystagmus (HP:0012043)1.87683498
136Nephroblastoma (Wilms tumor) (HP:0002667)1.87643736
137Abnormality of the preputium (HP:0100587)1.87400248
138Abnormality of the salivary glands (HP:0010286)1.86174145
139Mitochondrial inheritance (HP:0001427)1.85935686
140Abnormality of pyrimidine metabolism (HP:0004353)1.85549277
141Anophthalmia (HP:0000528)1.84489883
142Short 5th finger (HP:0009237)1.83247969
143Polyphagia (HP:0002591)1.81396431
144Increased CSF lactate (HP:0002490)1.80894084
145Abnormal hair whorl (HP:0010721)1.80726926
146Anencephaly (HP:0002323)1.80332178
147Abnormal mitochondria in muscle tissue (HP:0008316)1.78442483
148Protruding tongue (HP:0010808)1.75827735
149Partial duplication of the phalanx of hand (HP:0009999)1.71174262
150Hyperinsulinemic hypoglycemia (HP:0000825)1.69398756
151Hypoplasia of the pons (HP:0012110)1.69360498
152Bifid tongue (HP:0010297)1.69033886
153Hypomagnesemia (HP:0002917)1.68690861
154Triphalangeal thumb (HP:0001199)1.68093391
155Hypoglycemic seizures (HP:0002173)1.67475481
156Abnormality of the aortic arch (HP:0012303)1.67432177
157High anterior hairline (HP:0009890)1.66767486
158Scrotal hypoplasia (HP:0000046)1.66240635
159Duplication of thumb phalanx (HP:0009942)1.65392712
160Methylmalonic aciduria (HP:0012120)1.63378030
161Progressive macrocephaly (HP:0004481)1.63230204
162Preaxial foot polydactyly (HP:0001841)1.60515963
163Abnormality of the lacrimal duct (HP:0011481)1.59658254
164Increased hepatocellular lipid droplets (HP:0006565)1.58960022
165Abnormality of the middle phalanges of the toes (HP:0010183)1.58686830
166Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.58271210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.86495762
2LATS23.32028162
3CDC73.27982077
4ICK3.27940396
5WEE13.16800761
6TNIK3.14461748
7CDK122.92723020
8CDK192.68808193
9CASK2.44122825
10CDK72.42909523
11NEK12.37897379
12TAF12.31764878
13TTK2.27768220
14NME12.24717418
15VRK22.22790469
16PINK12.11441618
17PLK12.07987281
18MAP3K112.03311785
19EPHA22.01572401
20EIF2AK12.01390986
21DDR22.01283055
22NEK21.93532617
23MAP3K91.74533007
24WNK41.74389192
25PBK1.70529935
26AKT31.70327022
27OXSR11.69137409
28MAP3K61.65576025
29CHEK21.60614953
30SRPK11.58656583
31DAPK11.58348276
32MARK11.56029084
33ZAK1.55693369
34RPS6KB21.54647364
35WNK31.54635062
36TYRO31.52654751
37MAPK151.52192368
38TESK21.50183298
39DYRK31.49401286
40ATR1.42131769
41PLK41.40791598
42FGFR21.38465226
43TSSK61.37232543
44AURKA1.36351435
45MATK1.33285520
46AURKB1.29133146
47BMX1.26377308
48PAK41.26128460
49CHEK11.24514212
50NUAK11.20618012
51STK101.20417131
52YES11.19655573
53MAP3K81.19287366
54PRKCG1.15142100
55MAP2K61.14947138
56PASK1.13031664
57PIM11.11156420
58MAP3K101.10811719
59MST41.10769818
60STK38L1.08431594
61MAP3K41.08330154
62TLK11.05679998
63SIK21.05266829
64CDK61.04833329
65STK391.04012194
66GRK11.02293782
67ALK1.02229774
68NTRK21.02088256
69PLK31.01497312
70UHMK11.01148143
71VRK11.00609443
72CDK20.98834542
73BRSK20.97486244
74MAP2K70.97252952
75CDK40.95222950
76MKNK10.94060204
77MTOR0.93776822
78PIM20.92401480
79DMPK0.92238552
80MINK10.92226323
81DYRK1B0.91238841
82RPS6KC10.90810399
83RPS6KL10.90810399
84CSNK1G10.88098046
85CSNK1G20.87209337
86FGR0.86680972
87ATM0.85801352
88TAOK20.83753880
89NTRK30.83475094
90SGK2230.80984714
91SGK4940.80984714
92PAK10.80963426
93PHKG20.80889701
94PHKG10.80889701
95MAPK130.80796963
96MAP4K20.80574558
97CAMK1G0.79267128
98CSNK2A20.76164737
99STK40.75894216
100PDGFRA0.75828003
101EIF2AK30.75366064
102PAK30.75096325
103BRD40.74852664
104DYRK20.74418546
105CSNK2A10.73509820
106RPS6KA60.72801497
107EEF2K0.72367534
108BRSK10.71906910
109DYRK1A0.71734433
110MKNK20.69320001
111STK240.69091275
112TRIM280.68242977
113ACVR1B0.67855361
114NME20.66326669
115STK30.65616544
116CDK10.65447062
117BCKDK0.64968346
118CAMK1D0.63727271
119PRKD20.63485981
120CSNK1G30.62783311
121CSNK1E0.61728018
122PRPF4B0.61637373
123ERBB40.61263934
124GRK60.60277920
125PRKCI0.60154992
126AKT20.58452852
127CSK0.54872050
128MAP3K50.53096129
129BMPR1B0.52726635
130PNCK0.51529844
131CDC42BPA0.50358468
132CDK11A0.49286251
133FLT30.48985035
134RPS6KA40.48097650
135STK160.47444353
136TGFBR10.46744139
137CSNK1A10.46594411
138RPS6KA10.46560427
139SCYL20.46486358
140MET0.45683244
141PRKCZ0.45180549
142FGFR10.43853693
143MAPKAPK50.43566275
144MAPK70.42545157
145MELK0.41520236
146ADRBK20.41160566
147MAPKAPK30.40524688
148KDR0.39214472
149MAPK140.37042421
150PRKDC0.36976566
151PDK40.36380876
152PDK30.36380876

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.92857041
2DNA replication_Homo sapiens_hsa030304.87172072
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.79526940
4Base excision repair_Homo sapiens_hsa034103.44829155
5Spliceosome_Homo sapiens_hsa030403.34593308
6RNA transport_Homo sapiens_hsa030133.23525349
7Ribosome_Homo sapiens_hsa030103.18683587
8One carbon pool by folate_Homo sapiens_hsa006703.09786717
9RNA polymerase_Homo sapiens_hsa030202.83833706
10Nucleotide excision repair_Homo sapiens_hsa034202.80160757
11Homologous recombination_Homo sapiens_hsa034402.79544959
12Proteasome_Homo sapiens_hsa030502.77660665
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.68905564
14Nicotine addiction_Homo sapiens_hsa050332.39690236
15Cell cycle_Homo sapiens_hsa041102.28551772
16Fanconi anemia pathway_Homo sapiens_hsa034602.13584058
17mRNA surveillance pathway_Homo sapiens_hsa030152.01343276
18Pyrimidine metabolism_Homo sapiens_hsa002401.98177006
19Cardiac muscle contraction_Homo sapiens_hsa042601.94365016
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77893925
21Biosynthesis of amino acids_Homo sapiens_hsa012301.68006471
22Steroid biosynthesis_Homo sapiens_hsa001001.62749464
23Alzheimers disease_Homo sapiens_hsa050101.61885753
24RNA degradation_Homo sapiens_hsa030181.57679619
25p53 signaling pathway_Homo sapiens_hsa041151.54885893
26Non-homologous end-joining_Homo sapiens_hsa034501.48219304
27Basal transcription factors_Homo sapiens_hsa030221.47093138
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46257620
29Protein export_Homo sapiens_hsa030601.44599654
30Basal cell carcinoma_Homo sapiens_hsa052171.38508864
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34585626
32Hippo signaling pathway_Homo sapiens_hsa043901.29472184
33Hedgehog signaling pathway_Homo sapiens_hsa043401.27271985
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.17279661
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.15078137
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11849881
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10837917
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10352356
39Fructose and mannose metabolism_Homo sapiens_hsa000511.07329852
40Fatty acid biosynthesis_Homo sapiens_hsa000611.06019834
41Vitamin digestion and absorption_Homo sapiens_hsa049771.05113583
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.04831624
43Oocyte meiosis_Homo sapiens_hsa041141.03232458
44Folate biosynthesis_Homo sapiens_hsa007901.02423118
45Fatty acid elongation_Homo sapiens_hsa000621.01953702
46Phototransduction_Homo sapiens_hsa047440.98571785
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98480866
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98231292
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98030826
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95790059
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93211168
52Taste transduction_Homo sapiens_hsa047420.93173610
53TGF-beta signaling pathway_Homo sapiens_hsa043500.90682904
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89318265
55Purine metabolism_Homo sapiens_hsa002300.87866967
56Butanoate metabolism_Homo sapiens_hsa006500.87527734
57Adherens junction_Homo sapiens_hsa045200.86605292
58Selenocompound metabolism_Homo sapiens_hsa004500.85338569
59Epstein-Barr virus infection_Homo sapiens_hsa051690.84443137
60Notch signaling pathway_Homo sapiens_hsa043300.81720941
61Collecting duct acid secretion_Homo sapiens_hsa049660.78922377
62Propanoate metabolism_Homo sapiens_hsa006400.77000903
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76521313
64Arginine and proline metabolism_Homo sapiens_hsa003300.76324171
65Carbon metabolism_Homo sapiens_hsa012000.75965708
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73278435
67Wnt signaling pathway_Homo sapiens_hsa043100.72560099
68mTOR signaling pathway_Homo sapiens_hsa041500.71565516
69Glutathione metabolism_Homo sapiens_hsa004800.70141851
70Cocaine addiction_Homo sapiens_hsa050300.69935344
71Thyroid cancer_Homo sapiens_hsa052160.69877055
72GABAergic synapse_Homo sapiens_hsa047270.69629992
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68998418
74Sulfur relay system_Homo sapiens_hsa041220.68595099
75MicroRNAs in cancer_Homo sapiens_hsa052060.66497862
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66208061
77Viral carcinogenesis_Homo sapiens_hsa052030.66154845
78Synaptic vesicle cycle_Homo sapiens_hsa047210.65706185
79Systemic lupus erythematosus_Homo sapiens_hsa053220.64895177
80Huntingtons disease_Homo sapiens_hsa050160.64884567
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64399562
82Bladder cancer_Homo sapiens_hsa052190.62375793
83Ether lipid metabolism_Homo sapiens_hsa005650.62308447
84Morphine addiction_Homo sapiens_hsa050320.61435539
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61166134
86Retinol metabolism_Homo sapiens_hsa008300.60459759
87Glutamatergic synapse_Homo sapiens_hsa047240.59186634
88HTLV-I infection_Homo sapiens_hsa051660.58623352
89beta-Alanine metabolism_Homo sapiens_hsa004100.57637635
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56398062
91Serotonergic synapse_Homo sapiens_hsa047260.55798902
92Axon guidance_Homo sapiens_hsa043600.53720824
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53470859
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.53349279
95Dopaminergic synapse_Homo sapiens_hsa047280.51219877
96Tryptophan metabolism_Homo sapiens_hsa003800.51062702
97Tight junction_Homo sapiens_hsa045300.50425855
98Galactose metabolism_Homo sapiens_hsa000520.49913941
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.49660347
100Fat digestion and absorption_Homo sapiens_hsa049750.48923017
101Insulin secretion_Homo sapiens_hsa049110.48622505
102Fatty acid metabolism_Homo sapiens_hsa012120.46822540
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46714220
104Olfactory transduction_Homo sapiens_hsa047400.44510570
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44267132
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44111188
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43622189
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43329386
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42683259
110Pentose phosphate pathway_Homo sapiens_hsa000300.42651032
111Herpes simplex infection_Homo sapiens_hsa051680.40155681
112Colorectal cancer_Homo sapiens_hsa052100.38340067
113Amphetamine addiction_Homo sapiens_hsa050310.37331053
114Vitamin B6 metabolism_Homo sapiens_hsa007500.36691374
115Lysine degradation_Homo sapiens_hsa003100.32926127
116Parkinsons disease_Homo sapiens_hsa050120.32804489
117Melanoma_Homo sapiens_hsa052180.32698585
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31194180
119Pathways in cancer_Homo sapiens_hsa052000.31054562
120HIF-1 signaling pathway_Homo sapiens_hsa040660.29826808
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28721463
122Pyruvate metabolism_Homo sapiens_hsa006200.28407173
123Legionellosis_Homo sapiens_hsa051340.27182577
124Small cell lung cancer_Homo sapiens_hsa052220.26615966
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25866209
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23724608
127Metabolic pathways_Homo sapiens_hsa011000.23379217
128Linoleic acid metabolism_Homo sapiens_hsa005910.21880512
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21850873
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20756677
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17927075
132Arachidonic acid metabolism_Homo sapiens_hsa005900.16170710
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15272836
134Shigellosis_Homo sapiens_hsa051310.15177430
135Oxidative phosphorylation_Homo sapiens_hsa001900.12640598
136Antigen processing and presentation_Homo sapiens_hsa046120.11460446
137Acute myeloid leukemia_Homo sapiens_hsa052210.11043219
138Alcoholism_Homo sapiens_hsa050340.11003347
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09437907
140AMPK signaling pathway_Homo sapiens_hsa041520.09349653
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09078664
142Apoptosis_Homo sapiens_hsa042100.08997931
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07841028
144Proteoglycans in cancer_Homo sapiens_hsa052050.07763922
145Phenylalanine metabolism_Homo sapiens_hsa003600.07620061

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