FOXI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transepithelial transport (GO:0070633)8.55273407
2desmosome organization (GO:0002934)7.86571906
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.33531228
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.33531228
5cellular copper ion homeostasis (GO:0006878)7.06943023
6positive regulation of keratinocyte differentiation (GO:0045618)6.75349891
7hemidesmosome assembly (GO:0031581)6.34300422
8regulation of water loss via skin (GO:0033561)6.03256335
9antigen processing and presentation of endogenous antigen (GO:0019883)5.98964684
10ear development (GO:0043583)5.81012959
11copper ion transport (GO:0006825)5.70547061
12copper ion homeostasis (GO:0055070)5.66561641
13bundle of His cell to Purkinje myocyte communication (GO:0086069)5.54765399
14positive regulation of epidermal cell differentiation (GO:0045606)5.43136831
15excretion (GO:0007588)5.36483560
16sperm capacitation (GO:0048240)5.29180874
17establishment of skin barrier (GO:0061436)5.08320655
18hepatocyte apoptotic process (GO:0097284)5.07434725
19cytidine deamination (GO:0009972)4.95625338
20cytidine metabolic process (GO:0046087)4.95625338
21cytidine catabolic process (GO:0006216)4.95625338
22regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.89062651
23opioid receptor signaling pathway (GO:0038003)4.87460030
24bicarbonate transport (GO:0015701)4.86131473
25iron ion import (GO:0097286)4.85320224
26semaphorin-plexin signaling pathway (GO:0071526)4.84020306
27positive regulation of Cdc42 GTPase activity (GO:0043089)4.65488135
28multicellular organismal water homeostasis (GO:0050891)4.52757146
29ferric iron transport (GO:0015682)4.51832587
30trivalent inorganic cation transport (GO:0072512)4.51832587
31pattern specification involved in kidney development (GO:0061004)4.37373028
32response to water (GO:0009415)4.34204986
33negative regulation of protein oligomerization (GO:0032460)4.33956317
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.25645389
35negative regulation of keratinocyte proliferation (GO:0010839)4.23424426
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.20194101
37L-phenylalanine catabolic process (GO:0006559)4.20194101
38positive regulation of epidermis development (GO:0045684)4.17573304
39phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.16869548
40regulation of cell proliferation involved in kidney development (GO:1901722)4.14356358
41aminoglycoside antibiotic metabolic process (GO:0030647)4.11295580
42metanephric mesenchyme development (GO:0072075)4.08470531
43ATP hydrolysis coupled proton transport (GO:0015991)4.05738606
44energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.05738606
45biotin metabolic process (GO:0006768)4.03463524
46interferon-gamma secretion (GO:0072643)4.03069676
47pyrimidine ribonucleoside catabolic process (GO:0046133)4.00282613
48intestinal epithelial cell development (GO:0060576)3.97914267
49tryptophan metabolic process (GO:0006568)3.92319652
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.88147280
51L-phenylalanine metabolic process (GO:0006558)3.88147280
52cell differentiation involved in embryonic placenta development (GO:0060706)3.84609420
53regulation of keratinocyte differentiation (GO:0045616)3.80537002
54nephron tubule morphogenesis (GO:0072078)3.80143117
55nephron epithelium morphogenesis (GO:0072088)3.80143117
56water homeostasis (GO:0030104)3.73867886
57peptidyl-tyrosine autophosphorylation (GO:0038083)3.73274409
58type B pancreatic cell proliferation (GO:0044342)3.69151991
59epithelial cell-cell adhesion (GO:0090136)3.68963380
60L-serine transport (GO:0015825)3.68255753
61regulation of intracellular pH (GO:0051453)3.67175787
62branching involved in mammary gland duct morphogenesis (GO:0060444)3.66591015
63bone remodeling (GO:0046849)3.65854746
64lysine metabolic process (GO:0006553)3.65416243
65lysine catabolic process (GO:0006554)3.65416243
66amyloid precursor protein metabolic process (GO:0042982)3.64831367
67cell-substrate junction assembly (GO:0007044)3.62163844
68urate metabolic process (GO:0046415)3.61520021
69epithelial cell differentiation involved in prostate gland development (GO:0060742)3.60835219
70transferrin transport (GO:0033572)3.60310146
71positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.59289777
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.56734048
73regulation of fatty acid beta-oxidation (GO:0031998)3.55276662
74negative regulation of cell size (GO:0045792)3.54139508
75kidney mesenchyme development (GO:0072074)3.53791551
76import into cell (GO:0098657)3.53503947
77insulin-like growth factor receptor signaling pathway (GO:0048009)3.53082279
78membrane hyperpolarization (GO:0060081)3.52544586
79establishment of apical/basal cell polarity (GO:0035089)3.50110371
80myoblast migration (GO:0051451)3.49877794
81adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.48456070
82amyloid precursor protein catabolic process (GO:0042987)3.46762458
83positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.46393306
84glyoxylate metabolic process (GO:0046487)3.44775185
85planar cell polarity pathway involved in neural tube closure (GO:0090179)3.39892427
86norepinephrine metabolic process (GO:0042415)3.39337422
87striated muscle atrophy (GO:0014891)3.38826712
88regulation of cellular pH (GO:0030641)3.38105282
89negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.37272074
90synaptonemal complex assembly (GO:0007130)3.35946118
91cell differentiation involved in metanephros development (GO:0072202)3.35814458
92regulation of Cdc42 GTPase activity (GO:0043088)3.34400031
93negative regulation of microtubule polymerization (GO:0031115)3.34370561
94cardiac right ventricle morphogenesis (GO:0003215)3.33463243
95water transport (GO:0006833)3.33259578
96atrioventricular valve morphogenesis (GO:0003181)3.32130811
97regulation of apoptotic process involved in morphogenesis (GO:1902337)3.31016638
98organic cation transport (GO:0015695)3.30488257
99sodium ion homeostasis (GO:0055078)3.27964982
100calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.26864948
101trivalent inorganic anion homeostasis (GO:0072506)3.26120240
102phosphate ion homeostasis (GO:0055062)3.26120240
103endothelial cell chemotaxis (GO:0035767)3.23509053
104regulation of interleukin-13 production (GO:0032656)3.22845144
105kynurenine metabolic process (GO:0070189)3.22765130
106molting cycle (GO:0042303)3.22566020
107hair cycle (GO:0042633)3.22566020
108maternal placenta development (GO:0001893)3.22122787
109vagina development (GO:0060068)3.20753744
110epidermis development (GO:0008544)3.19837057
111serine transport (GO:0032329)3.18582976
112response to copper ion (GO:0046688)3.18473932
113negative regulation of cell fate specification (GO:0009996)3.18328397
114drug transmembrane transport (GO:0006855)3.16771112
115regulation of protein localization to cell surface (GO:2000008)3.15230143
116positive regulation of protein homooligomerization (GO:0032464)3.14997257
117tricarboxylic acid metabolic process (GO:0072350)3.14201800
118regulation of establishment or maintenance of cell polarity (GO:0032878)3.13766906
119iron ion transport (GO:0006826)3.11979609
120regulation of pH (GO:0006885)3.11511177
121mesonephros development (GO:0001823)3.10962342
122negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10812322
123regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.09326457
124quaternary ammonium group transport (GO:0015697)3.08194823
125apoptotic process involved in morphogenesis (GO:0060561)3.08048243
126vesicle targeting (GO:0006903)3.07390146
127focal adhesion assembly (GO:0048041)3.06555348
128cell-substrate adherens junction assembly (GO:0007045)3.06555348
129tryptophan catabolic process (GO:0006569)3.06466191
130indole-containing compound catabolic process (GO:0042436)3.06466191
131indolalkylamine catabolic process (GO:0046218)3.06466191
132keratinocyte development (GO:0003334)3.05636246
133phosphate ion transport (GO:0006817)3.05629544
134positive regulation of fatty acid beta-oxidation (GO:0032000)3.04563439
135regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.04252464
136activation of Rac GTPase activity (GO:0032863)3.03926483
137cellular modified amino acid catabolic process (GO:0042219)3.02414331
138regulation of cardioblast differentiation (GO:0051890)3.00255731
139regulation of female gonad development (GO:2000194)3.00098626
140negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.98860253
141renal tubule morphogenesis (GO:0061333)2.97790734
142skeletal muscle adaptation (GO:0043501)2.97048379
143monovalent inorganic cation homeostasis (GO:0055067)2.95760874
144response to food (GO:0032094)2.94852655
145negative regulation of Ras GTPase activity (GO:0034261)2.94004701
146response to mercury ion (GO:0046689)2.92816743
1472-oxoglutarate metabolic process (GO:0006103)2.92275276
148short-chain fatty acid metabolic process (GO:0046459)2.91585853
149fluid transport (GO:0042044)2.88325316
150pH reduction (GO:0045851)2.88144010
151phagosome maturation (GO:0090382)2.87897111
152cornea development in camera-type eye (GO:0061303)2.86376419
153negative regulation of kidney development (GO:0090185)2.85901271
154carnitine transport (GO:0015879)2.85310659
155amino-acid betaine transport (GO:0015838)2.85310659
156positive regulation of mesonephros development (GO:0061213)2.85018614
157COPI coating of Golgi vesicle (GO:0048205)2.84221261
158Golgi transport vesicle coating (GO:0048200)2.84221261
159embryonic eye morphogenesis (GO:0048048)2.84169698
160aromatic amino acid family catabolic process (GO:0009074)2.82423958
161muscle atrophy (GO:0014889)2.82423362
162aspartate family amino acid catabolic process (GO:0009068)2.81913345
163alpha-linolenic acid metabolic process (GO:0036109)2.81776041
164intracellular estrogen receptor signaling pathway (GO:0030520)2.81543092
165regulation of epidermal cell differentiation (GO:0045604)2.80929993
166vasodilation (GO:0042311)2.80686512
167O-glycan processing (GO:0016266)2.80661479
168ectoderm development (GO:0007398)2.78316786
169surfactant homeostasis (GO:0043129)2.78254033
170adherens junction assembly (GO:0034333)2.75441994
171regulation of epidermis development (GO:0045682)2.74622742
172sensory perception of taste (GO:0050909)2.74175335
173synaptonemal complex organization (GO:0070193)2.73831437
174establishment of monopolar cell polarity (GO:0061162)2.72578225
175establishment or maintenance of monopolar cell polarity (GO:0061339)2.72578225
176apical protein localization (GO:0045176)2.72103351
177positive regulation of odontogenesis (GO:0042482)2.71680104
178regulation of transforming growth factor beta1 production (GO:0032908)2.71421429
179indolalkylamine metabolic process (GO:0006586)2.71295153
180regulation of clathrin-mediated endocytosis (GO:2000369)2.71023118
181epithelial cell maturation (GO:0002070)2.68524212
182negative regulation of cell fate commitment (GO:0010454)2.68498935
183establishment of planar polarity (GO:0001736)2.66604858
184establishment of tissue polarity (GO:0007164)2.66604858
185hair follicle development (GO:0001942)2.66186572
186regulation of establishment of cell polarity (GO:2000114)2.65424024
187trophectodermal cell differentiation (GO:0001829)2.65252627
188negative regulation of cell junction assembly (GO:1901889)2.65124783
189phenylpropanoid metabolic process (GO:0009698)2.64115085
190fatty acid beta-oxidation (GO:0006635)2.63833803
191regulation of mesonephros development (GO:0061217)2.62219738
192proline metabolic process (GO:0006560)2.60379531
193cellular response to toxic substance (GO:0097237)2.59841568
194ganglion development (GO:0061548)2.59046243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CHD7_19251738_ChIP-ChIP_MESCs_Mouse5.30522091
2ZNF263_19887448_ChIP-Seq_K562_Human3.62309807
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.42744002
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34002674
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.18995145
6IKZF1_21737484_ChIP-ChIP_HCT116_Human3.14395297
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84946033
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.78305356
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.66473072
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53786798
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46008178
12FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.44254731
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38119621
14ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.28971877
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.27557659
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.20261148
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19050283
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.16233695
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.15395026
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.04832729
21CDX2_20551321_ChIP-Seq_CACO-2_Human2.02031164
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91469817
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89286871
24SOX2_20726797_ChIP-Seq_SW620_Human1.85328409
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.84878891
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83998497
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.81396406
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76471755
29CLOCK_20551151_ChIP-Seq_293T_Human1.75083355
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.74785415
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73583103
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.73542198
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.71757362
34SMC4_20622854_ChIP-Seq_HELA_Human1.68539186
35P68_20966046_ChIP-Seq_HELA_Human1.67927586
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66642794
37RACK7_27058665_Chip-Seq_MCF-7_Human1.62696752
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61578054
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58729456
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56666814
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54482070
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53345728
43TCF7_22412390_ChIP-Seq_EML_Mouse1.53142879
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52074626
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48364432
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48114456
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.45779610
48AHR_22903824_ChIP-Seq_MCF-7_Human1.45574296
49VDR_21846776_ChIP-Seq_THP-1_Human1.44044000
50ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41347132
51CREB1_26743006_Chip-Seq_LNCaP_Human1.37576734
52TP53_16413492_ChIP-PET_HCT116_Human1.37005490
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36270122
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34329464
55TP63_22573176_ChIP-Seq_HFKS_Human1.33064075
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32264706
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32087718
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31793187
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.31752562
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.31563356
61FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31302568
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31028474
63MYC_22102868_ChIP-Seq_BL_Human1.30730395
64KDM2B_26808549_Chip-Seq_DND41_Human1.30302861
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30286591
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30285296
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27499335
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26339971
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25625767
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24457607
71SCL_19346495_ChIP-Seq_HPC-7_Human1.23387232
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23065022
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21629664
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21246269
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.20719249
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.19781843
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18966656
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.17433284
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16988765
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15036371
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15008868
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14714549
83CTCF_27219007_Chip-Seq_Bcells_Human1.14688185
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14020638
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13408358
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10008320
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08794358
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08288817
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07021608
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06070278
91* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04854559
92* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03520297
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.03205420
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02291484
95* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02246806
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01927876
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01927876
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01907915
99TP53_22127205_ChIP-Seq_IMR90_Human1.01730541
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01518836
101CTCF_26484167_Chip-Seq_Bcells_Mouse1.01357823
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00933213
103BCOR_27268052_Chip-Seq_Bcells_Human0.98715830
104CDX2_22108803_ChIP-Seq_LS180_Human0.98423812
105SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98288430
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98253659
107EOMES_21245162_ChIP-Seq_HESCs_Human0.97794554
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.97684173
109MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97336878
110TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97068965
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.97057475
112TBX20_22080862_ChIP-Seq_HEART_Mouse0.97057475
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96941475
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96255609
115GATA4_25053715_ChIP-Seq_YYC3_Human0.96114126
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95854660
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95775161
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95070300
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94593131
120LXR_22292898_ChIP-Seq_THP-1_Human0.93391542
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.92082338
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91964528
123KDM5A_27292631_Chip-Seq_BREAST_Human0.91377083
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.90494772
125EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90418373
126RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90418373
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90406508
128PHF8_20622854_ChIP-Seq_HELA_Human0.88935726
129GATA2_19941826_ChIP-Seq_K562_Human0.88328123
130E2F1_20622854_ChIP-Seq_HELA_Human0.87926419
131ELF5_23300383_ChIP-Seq_T47D_Human0.87892377
132ATF3_27146783_Chip-Seq_COLON_Human0.86922952
133KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86512123
134KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86512123
135KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86512123
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85817450
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85765392
138SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.85523494
139RARB_24833708_ChIP-Seq_LIVER_Mouse0.85400774
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84846730
141KDM2B_26808549_Chip-Seq_K562_Human0.84398230
142TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84396794
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84309040
144GATA6_25053715_ChIP-Seq_YYC3_Human0.83787209
145TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82955448
146KLF5_25053715_ChIP-Seq_YYC3_Human0.82836676
147EED_16625203_ChIP-ChIP_MESCs_Mouse0.82645169
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82511849
149DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82206714
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81920865
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81495685
152* MYC_27129775_Chip-Seq_CORNEA_Mouse0.81268626
153TDRD3_21172665_ChIP-Seq_MCF-7_Human0.80969985
154P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80104365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer6.87546480
2MP0002163_abnormal_gland_morphology5.90520625
3MP0000579_abnormal_nail_morphology4.95760646
4MP0004742_abnormal_vestibular_system4.85864991
5* MP0004885_abnormal_endolymph4.73332202
6MP0004381_abnormal_hair_follicle4.02944520
7MP0002132_abnormal_respiratory_system3.95842971
8MP0005379_endocrine/exocrine_gland_phen3.28916353
9MP0008872_abnormal_physiological_respon3.23389054
10MP0000462_abnormal_digestive_system3.17214244
11MP0003705_abnormal_hypodermis_morpholog3.16419029
12MP0005076_abnormal_cell_differentiation3.10051872
13MP0000383_abnormal_hair_follicle2.99008529
14MP0000566_synostosis2.97977603
15MP0010234_abnormal_vibrissa_follicle2.95419095
16MP0002089_abnormal_postnatal_growth/wei2.88929957
17MP0002277_abnormal_respiratory_mucosa2.82914696
18MP0000467_abnormal_esophagus_morphology2.73892442
19MP0004043_abnormal_pH_regulation2.56104525
20MP0000377_abnormal_hair_follicle2.47969239
21MP0005360_urolithiasis2.46722486
22MP0000569_abnormal_digit_pigmentation2.46423059
23MP0001177_atelectasis2.39865107
24MP0001216_abnormal_epidermal_layer2.31881744
25MP0002139_abnormal_hepatobiliary_system2.31463188
26MP0005408_hypopigmentation2.29948044
27MP0003878_abnormal_ear_physiology2.27878302
28MP0005377_hearing/vestibular/ear_phenot2.27878302
29MP0005171_absent_coat_pigmentation2.22294091
30MP0002060_abnormal_skin_morphology2.06146832
31MP0000613_abnormal_salivary_gland1.96715178
32MP0005220_abnormal_exocrine_pancreas1.95711448
33MP0001270_distended_abdomen1.92094441
34MP0008260_abnormal_autophagy1.89105097
35MP0002249_abnormal_larynx_morphology1.85139784
36* MP0009643_abnormal_urine_homeostasis1.81310967
37MP0005058_abnormal_lysosome_morphology1.79218915
38MP0001881_abnormal_mammary_gland1.77953684
39MP0010771_integument_phenotype1.75110998
40MP0003195_calcinosis1.75001878
41MP0000762_abnormal_tongue_morphology1.70542433
42MP0005332_abnormal_amino_acid1.69404175
43MP0004019_abnormal_vitamin_homeostasis1.65472822
44MP0005409_darkened_coat_color1.65460042
45MP0001765_abnormal_ion_homeostasis1.63694638
46MP0000678_abnormal_parathyroid_gland1.59460823
47MP0001663_abnormal_digestive_system1.57819949
48MP0009780_abnormal_chondrocyte_physiolo1.56726389
49MP0005075_abnormal_melanosome_morpholog1.56293232
50MP0000427_abnormal_hair_cycle1.56253808
51MP0003329_amyloid_beta_deposits1.55646316
52MP0005636_abnormal_mineral_homeostasis1.50185903
53MP0001756_abnormal_urination1.46320644
54MP0002254_reproductive_system_inflammat1.44236394
55MP0009931_abnormal_skin_appearance1.34908710
56MP0004147_increased_porphyrin_level1.32756466
57MP0001849_ear_inflammation1.30893520
58MP0002233_abnormal_nose_morphology1.26419560
59MP0002098_abnormal_vibrissa_morphology1.25905739
60MP0000371_diluted_coat_color1.25828132
61MP0003183_abnormal_peptide_metabolism1.23920489
62MP0001984_abnormal_olfaction1.23495855
63MP0004782_abnormal_surfactant_physiolog1.23312330
64MP0000372_irregular_coat_pigmentation1.22540142
65MP0005381_digestive/alimentary_phenotyp1.20819501
66* MP0002136_abnormal_kidney_physiology1.16419189
67MP0005388_respiratory_system_phenotype1.14925920
68MP0002133_abnormal_respiratory_system1.14925920
69MP0000367_abnormal_coat/_hair1.14405105
70MP0003638_abnormal_response/metabolism_1.14293771
71MP0010386_abnormal_urinary_bladder1.09553604
72MP0002938_white_spotting1.06761676
73MP0002168_other_aberrant_phenotype1.06177981
74MP0003566_abnormal_cell_adhesion1.05441279
75MP0003936_abnormal_reproductive_system1.03355869
76MP0004185_abnormal_adipocyte_glucose1.02513801
77MP0000647_abnormal_sebaceous_gland1.01650839
78* MP0001963_abnormal_hearing_physiology1.01396932
79MP0003866_abnormal_defecation0.99559113
80MP0000534_abnormal_ureter_morphology0.99037825
81MP0002295_abnormal_pulmonary_circulatio0.98884773
82MP0004233_abnormal_muscle_weight0.96864351
83MP0002877_abnormal_melanocyte_morpholog0.96845568
84MP0003045_fibrosis0.95573399
85MP0004272_abnormal_basement_membrane0.94259200
86MP0003942_abnormal_urinary_system0.91864184
87MP0001340_abnormal_eyelid_morphology0.91672440
88MP0001873_stomach_inflammation0.88852657
89MP0009840_abnormal_foam_cell0.87935655
90MP0005423_abnormal_somatic_nervous0.86929801
91MP0003941_abnormal_skin_development0.86819769
92MP0005275_abnormal_skin_tensile0.86681481
93MP0004264_abnormal_extraembryonic_tissu0.85433101
94MP0005248_abnormal_Harderian_gland0.85431554
95MP0001348_abnormal_lacrimal_gland0.84526942
96MP0008438_abnormal_cutaneous_collagen0.83646647
97MP0005085_abnormal_gallbladder_physiolo0.81883013
98MP0001191_abnormal_skin_condition0.81416651
99MP0010030_abnormal_orbit_morphology0.80466133
100MP0003453_abnormal_keratinocyte_physiol0.78935956
101MP0001664_abnormal_digestion0.78595457
102MP0000604_amyloidosis0.78524039
103MP0002009_preneoplasia0.77850768
104MP0002108_abnormal_muscle_morphology0.77755048
105MP0009672_abnormal_birth_weight0.77717711
106MP0002282_abnormal_trachea_morphology0.77364117
107MP0000538_abnormal_urinary_bladder0.77055158
108MP0005174_abnormal_tail_pigmentation0.76814748
109MP0005083_abnormal_biliary_tract0.75042103
110MP0008569_lethality_at_weaning0.74560758
111MP0002896_abnormal_bone_mineralization0.74474754
112MP0001727_abnormal_embryo_implantation0.74459210
113MP0004947_skin_inflammation0.74182523
114MP0002138_abnormal_hepatobiliary_system0.73266577
115MP0010352_gastrointestinal_tract_polyps0.73024852
116MP0005375_adipose_tissue_phenotype0.72371400
117MP0000537_abnormal_urethra_morphology0.72099614
118MP0005666_abnormal_adipose_tissue0.71819303
119MP0005451_abnormal_body_composition0.70938863
120MP0000470_abnormal_stomach_morphology0.69598586
121MP0001958_emphysema0.65649323
122MP0003191_abnormal_cellular_cholesterol0.65379202
123MP0003690_abnormal_glial_cell0.63534563
124MP0005395_other_phenotype0.63305231
125MP0002796_impaired_skin_barrier0.63189823
126MP0003693_abnormal_embryo_hatching0.63084971
127MP0003115_abnormal_respiratory_system0.63058223
128MP0000858_altered_metastatic_potential0.62886267
129MP0005310_abnormal_salivary_gland0.62132160
130MP0002933_joint_inflammation0.60482533
131MP0005365_abnormal_bile_salt0.60459840
132MP0008961_abnormal_basal_metabolism0.60143105
133MP0001666_abnormal_nutrient_absorption0.59361644
134MP0003123_paternal_imprinting0.57539245
135* MP0001485_abnormal_pinna_reflex0.56736375
136MP0002118_abnormal_lipid_homeostasis0.55915738
137MP0002909_abnormal_adrenal_gland0.52917897
138* MP0002116_abnormal_craniofacial_bone0.52739228
139MP0005647_abnormal_sex_gland0.51002250
140MP0005621_abnormal_cell_physiology0.50646414
141MP0005508_abnormal_skeleton_morphology0.50330148
142MP0000003_abnormal_adipose_tissue0.50307763
143MP0005584_abnormal_enzyme/coenzyme_acti0.49117159
144MP0000230_abnormal_systemic_arterial0.47843227
145MP0005023_abnormal_wound_healing0.47422351
146MP0000627_abnormal_mammary_gland0.47111571
147MP0009384_cardiac_valve_regurgitation0.46958178
148MP0008875_abnormal_xenobiotic_pharmacok0.46814696
149MP0002970_abnormal_white_adipose0.45754788
150MP0010630_abnormal_cardiac_muscle0.45695995
151MP0003763_abnormal_thymus_physiology0.45301778
152MP0004858_abnormal_nervous_system0.44624798
153MP0002751_abnormal_autonomic_nervous0.42978196
154MP0010329_abnormal_lipoprotein_level0.42954094
155MP0005501_abnormal_skin_physiology0.42844663
156* MP0002135_abnormal_kidney_morphology0.41920842
157MP0010678_abnormal_skin_adnexa0.41874919
158MP0002653_abnormal_ependyma_morphology0.41199385
159MP0003879_abnormal_hair_cell0.40529364
160MP0003252_abnormal_bile_duct0.38373628

Predicted human phenotypes

RankGene SetZ-score
1Hypokalemic alkalosis (HP:0001949)8.82043480
2* Morphological abnormality of the inner ear (HP:0011390)8.50390138
3Ileus (HP:0002595)7.58281678
4Renal salt wasting (HP:0000127)7.17094606
5Hyperactive renin-angiotensin system (HP:0000841)7.11206601
6Metabolic alkalosis (HP:0200114)6.97081761
7Hyperaldosteronism (HP:0000859)6.93650759
8Rectal prolapse (HP:0002035)6.37622344
9Male infertility (HP:0003251)6.30753566
10Tinnitus (HP:0000360)5.13418612
11Abnormality of the right ventricle (HP:0001707)4.91273094
12Alkalosis (HP:0001948)4.88281017
13Hyponatremia (HP:0002902)4.63438328
14Polyuria (HP:0000103)4.59171917
15Abnormality of sodium homeostasis (HP:0010931)4.28237422
16Hypercalciuria (HP:0002150)4.28199164
17Abnormal urine output (HP:0012590)4.28034334
18Fragile nails (HP:0001808)4.20571377
19Abnormality of renal excretion (HP:0011036)4.20484816
20Tubulointerstitial fibrosis (HP:0005576)4.18525259
21Abnormality of nail color (HP:0100643)4.17848619
22J-shaped sella turcica (HP:0002680)4.16937937
23Concave nail (HP:0001598)4.10851726
24Chronic bronchitis (HP:0004469)4.07624715
25Hypokalemia (HP:0002900)3.97419816
26Azoospermia (HP:0000027)3.83519403
27Abnormality of renin-angiotensin system (HP:0000847)3.71158620
28Micronodular cirrhosis (HP:0001413)3.70815904
29Milia (HP:0001056)3.68312293
30Amelogenesis imperfecta (HP:0000705)3.59882331
31Septate vagina (HP:0001153)3.55461866
32Adrenal overactivity (HP:0002717)3.55219516
33Abnormality of potassium homeostasis (HP:0011042)3.33002830
34Broad face (HP:0000283)3.28949055
35Plantar hyperkeratosis (HP:0007556)3.26292055
36Lip pit (HP:0100267)3.22949104
37Decreased circulating renin level (HP:0003351)3.17032589
38Renal tubular acidosis (HP:0001947)3.16543162
39Hyperkalemia (HP:0002153)3.15978750
40Hypotrichosis (HP:0001006)3.13117134
41Sparse lateral eyebrow (HP:0005338)2.98739949
42Abdominal distention (HP:0003270)2.93439829
43Advanced eruption of teeth (HP:0006288)2.92937029
44Distal lower limb muscle weakness (HP:0009053)2.87674256
45Nail dystrophy (HP:0008404)2.86449990
46Increased circulating renin level (HP:0000848)2.86384508
47Woolly hair (HP:0002224)2.86242412
48Dehydration (HP:0001944)2.82750694
49Selective tooth agenesis (HP:0001592)2.80424769
50Abnormal hair laboratory examination (HP:0003328)2.77620762
51Thick nail (HP:0001805)2.74657604
52Exocrine pancreatic insufficiency (HP:0001738)2.73855655
53Vascular calcification (HP:0004934)2.67196323
54Abnormal spermatogenesis (HP:0008669)2.67023499
55Abnormality of the renal cortex (HP:0011035)2.65318951
56Right ventricular cardiomyopathy (HP:0011663)2.64420696
57Hypothermia (HP:0002045)2.59877072
58Ridged nail (HP:0001807)2.58589717
59Atrophic scars (HP:0001075)2.57806954
60Tubulointerstitial abnormality (HP:0001969)2.55102241
61Flat acetabular roof (HP:0003180)2.54291420
62Large eyes (HP:0001090)2.51470544
63Short nail (HP:0001799)2.49789033
64Glomerulosclerosis (HP:0000096)2.49456358
65Pterygium (HP:0001059)2.48850069
66Gout (HP:0001997)2.47458813
67Abnormality of the dental pulp (HP:0006479)2.45983034
68Deformed sella turcica (HP:0002681)2.45780472
69Cardiovascular calcification (HP:0011915)2.45494536
70Osteomalacia (HP:0002749)2.45448835
71Obstructive sleep apnea (HP:0002870)2.45188860
72Gastrointestinal dysmotility (HP:0002579)2.44744231
73Cervical subluxation (HP:0003308)2.42918736
74Diaphragmatic weakness (HP:0009113)2.41819508
75Curly hair (HP:0002212)2.39741449
76Aplasia cutis congenita (HP:0001057)2.38050504
77Absent frontal sinuses (HP:0002688)2.36979317
78Lymphangioma (HP:0100764)2.35810837
79Abnormality of permanent molar morphology (HP:0011071)2.35661617
80Abnormality of the dental root (HP:0006486)2.35661617
81Taurodontia (HP:0000679)2.35661617
82Bronchiectasis (HP:0002110)2.35492620
83Germ cell neoplasia (HP:0100728)2.34822441
84Asymmetry of the thorax (HP:0001555)2.26251748
85Microglossia (HP:0000171)2.24733340
86Hypoplasia of dental enamel (HP:0006297)2.23080996
87Renal tubular dysfunction (HP:0000124)2.22348720
88Hypomagnesemia (HP:0002917)2.17655178
89Broad distal phalanx of finger (HP:0009836)2.14661998
90Abnormality of molar morphology (HP:0011070)2.14051435
91Abnormality of molar (HP:0011077)2.14051435
92Abnormality of the frontal sinuses (HP:0002687)2.08745689
93Ventricular tachycardia (HP:0004756)2.08478514
94Macroorchidism (HP:0000053)2.08241469
95Natal tooth (HP:0000695)2.07706334
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.07258461
97Alopecia of scalp (HP:0002293)2.04266768
98Palmoplantar hyperkeratosis (HP:0000972)2.02802519
99Spinal cord compression (HP:0002176)2.02693624
100Long toe (HP:0010511)2.01653465
101* Abnormality of cochlea (HP:0000375)11.5861785
102Abnormality of chloride homeostasis (HP:0011422)11.4602637
103Hypotension (HP:0002615)1.99031871
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98872732
105Congenital ichthyosiform erythroderma (HP:0007431)1.98818453
106Aplasia of the musculature (HP:0100854)1.98101091
107Hyperphosphaturia (HP:0003109)1.96420054
108Chondrocalcinosis (HP:0000934)1.93625415
109Flattened epiphyses (HP:0003071)1.92885808
110Upper limb amyotrophy (HP:0009129)1.92785190
111Distal upper limb amyotrophy (HP:0007149)1.92785190
112Esophageal varix (HP:0002040)1.92412355
113Abnormal drinking behavior (HP:0030082)1.91143949
114Polydipsia (HP:0001959)1.91143949
115Sparse eyelashes (HP:0000653)1.91136734
116Abnormality of purine metabolism (HP:0004352)1.90940974
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89932408
118Abnormality of the distal phalanges of the toes (HP:0010182)1.88378317
119* Hyperparathyroidism (HP:0000843)1.88120701
120Hypercortisolism (HP:0001578)1.87620088
121Hyperglycinuria (HP:0003108)1.87508024
122Hypoparathyroidism (HP:0000829)1.86833092
123Down-sloping shoulders (HP:0200021)1.86522053
124Abnormality of magnesium homeostasis (HP:0004921)1.84892565
125Onycholysis (HP:0001806)1.83993606
126Bicornuate uterus (HP:0000813)1.83764885
127Abnormality of urine glucose concentration (HP:0011016)1.83763318
128Glycosuria (HP:0003076)1.83763318
129Abnormal blistering of the skin (HP:0008066)1.83234997
130* Vertigo (HP:0002321)1.82255609
131Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81971316
132Hyperacusis (HP:0010780)1.81889791
133Bronchomalacia (HP:0002780)1.81719459
134Spinal muscular atrophy (HP:0007269)1.80695155
135Nephrolithiasis (HP:0000787)1.79572787
136Exostoses (HP:0100777)1.79492950
137Vacuolated lymphocytes (HP:0001922)1.79457049
138Metabolic acidosis (HP:0001942)1.79133326
139Acanthosis nigricans (HP:0000956)1.78910187
140Increased cerebral lipofuscin (HP:0011813)1.78687861
141Abnormality of Sharpey fibers (HP:0100685)1.77853796
142Palmar hyperkeratosis (HP:0010765)1.77019156
143Popliteal pterygium (HP:0009756)1.75742183
144Abnormality of the salivary glands (HP:0010286)1.75702936
145Abnormal biliary tract morphology (HP:0012440)1.74870747
146Abnormal urine phosphate concentration (HP:0012599)1.74339641
147Abnormality of renal resorption (HP:0011038)1.73323981
148Nephrocalcinosis (HP:0000121)1.71902527
149Alveolar cell carcinoma (HP:0006519)1.66782686
150Stomach cancer (HP:0012126)1.62631438
151Tetany (HP:0001281)1.61577341
152Proximal tubulopathy (HP:0000114)1.57696253
153Abnormality of glutamine family amino acid metabolism (HP:0010902)1.53538627
154Hyperuricemia (HP:0002149)1.50043443
155Increased purine levels (HP:0004368)1.50043443
156Pili torti (HP:0003777)1.49150832
157Arterial tortuosity (HP:0005116)1.48824826
158Bilateral sensorineural hearing impairment (HP:0008619)1.48034508
159Neoplasm of the tracheobronchial system (HP:0100552)1.46395522
160Severe visual impairment (HP:0001141)1.39163406
161Pulmonary fibrosis (HP:0002206)1.37155449
162Abnormal number of incisors (HP:0011064)1.35979512
163Abnormality of glycine metabolism (HP:0010895)1.32236984
164Abnormality of serine family amino acid metabolism (HP:0010894)1.32236984
165Recurrent pneumonia (HP:0006532)1.31981242
166Spastic diplegia (HP:0001264)1.31905943
167Vascular tortuosity (HP:0004948)1.30092715
168Submucous cleft hard palate (HP:0000176)1.29118090
169Abnormality of the renal medulla (HP:0100957)1.28383945
170Hypoplasia of the iris (HP:0007676)1.27791601
171Generalized aminoaciduria (HP:0002909)1.27535205
172Bronchitis (HP:0012387)1.27530314
173Abnormality of transition element cation homeostasis (HP:0011030)1.26269865
174Vomiting (HP:0002013)1.23006275
175Abnormality of the nasal septum (HP:0000419)1.19343552
176Protuberant abdomen (HP:0001538)1.18580384
177Abnormality of nucleobase metabolism (HP:0010932)1.18477274
178Tachypnea (HP:0002789)1.18367641
179Thin bony cortex (HP:0002753)1.17382899

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKG23.71221927
2SMG13.71064646
3WNK42.68504423
4STK392.51449634
5SIK12.37341517
6MAPKAPK32.11704345
7OXSR12.10386764
8VRK22.04108831
9FRK2.01915275
10LMTK214.7318431
11CDK121.97217121
12MATK1.91586136
13IRAK31.89400398
14ICK1.67667309
15NME11.65799609
16TAOK11.50670019
17MUSK1.47248216
18EEF2K1.44798354
19NEK61.38613001
20MAP3K31.37420553
21SCYL21.26819276
22PTK21.19851724
23WNK31.17749550
24DAPK21.17494083
25EPHA21.16259454
26MAP3K21.05917116
27TESK21.04140147
28PRKD21.03602869
29MTOR0.96875229
30TRIB30.91362550
31ERBB20.87344254
32LATS10.85669449
33FER0.85025398
34EPHB10.84901790
35SIK30.83126489
36IRAK20.82097545
37CSF1R0.81694665
38IKBKB0.76910348
39ROCK10.76446360
40CAMK2G0.75537343
41PRPF4B0.74911121
42ILK0.74417362
43MAP3K60.74103176
44MST40.74068446
45SGK2230.72635215
46SGK4940.72635215
47PRKAA10.71316042
48SGK20.70672291
49ERBB30.70456370
50SGK30.67557264
51PIM20.66205952
52NME20.62999572
53MAPKAPK20.62359890
54TBK10.59586610
55CAMK2B0.59533066
56TLK10.57666624
57PDK20.56819677
58CDK70.54227922
59EPHA30.54194914
60LRRK20.51959876
61MAP3K10.50080360
62RPS6KA10.49931047
63PKN20.49491677
64MAPK150.48075706
65WNK10.47991684
66MARK20.47896027
67PRKCE0.46650660
68MAP3K110.46175007
69ADRBK10.45366060
70DYRK30.44784600
71RPS6KB10.41399028
72IRAK40.41318455
73RPS6KL10.41102368
74RPS6KC10.41102368
75DYRK1B0.40613180
76PTK60.40502213
77SRPK10.39846955
78MELK0.38751928
79DAPK10.37871241
80CAMK2D0.36835013
81CAMKK10.36796229
82EIF2AK10.35481520
83RIPK10.35146564
84TRPM70.35058327
85BLK0.34683097
86STK38L0.34009059
87UHMK10.33530810
88MAP2K10.33180278
89MET0.33069196
90BMX0.32071742
91ERN10.31304346
92NUAK10.30346623
93DYRK1A0.29229630
94CDC42BPA0.29013598
95HIPK20.28957950
96BCKDK0.28887428
97CDK90.28579623
98MAPK80.27333412
99MAP2K20.26912768
100ARAF0.26816650
101STK100.26753911
102BMPR20.26703370
103CSNK1A1L0.26588965
104FGFR40.24864158
105CDK80.24595395
106CAMK1G0.23553326
107CAMK40.23443131
108PRKD10.23378602
109AURKA0.21658872
110DMPK0.21481498
111IRAK10.21220892
112RPS6KA40.19413838
113CAMK1D0.19253675
114GRK60.19061873
115CSNK1G10.18464088
116PRKCH0.17962245
117PIK3CA0.17605993
118KSR20.17297636
119STK380.17011196
120ROCK20.16333679
121TESK10.15751824
122CDK60.15566995
123PAK30.15508913
124SIK20.15371719
125PRKCD0.14832141
126RPS6KA20.14685769
127LATS20.13336831
128RPS6KB20.12496303
129PRKACG0.12483543
130CHUK0.11739248
131GSK3A0.11609712
132RET0.11386357
133PRKG10.10792932
134AKT20.10664372
135PAK40.10232558
136BRD40.10183179
137CSNK1G30.10026022
138PDPK10.09306955
139DAPK30.09189469
140MST1R0.08917503
141TTN0.08707493
142CSNK1G20.08061767
143SGK10.07808666
144PRKCZ0.07553578
145MAP3K70.07284304
146JAK10.07176936
147DDR20.07139921
148PRKCI0.06828491
149RPS6KA60.06814484

Predicted pathways (KEGG)

RankGene SetZ-score
1Vibrio cholerae infection_Homo sapiens_hsa051104.31459335
2Collecting duct acid secretion_Homo sapiens_hsa049664.00006477
3Thyroid cancer_Homo sapiens_hsa052162.76070652
4Notch signaling pathway_Homo sapiens_hsa043302.71460121
5Sulfur metabolism_Homo sapiens_hsa009202.60030079
6Acute myeloid leukemia_Homo sapiens_hsa052212.56328137
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.46904386
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.24642876
9Mineral absorption_Homo sapiens_hsa049782.15784638
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02780469
11ABC transporters_Homo sapiens_hsa020102.02427110
12Bile secretion_Homo sapiens_hsa049761.96102573
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95221441
14Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.94810267
15Propanoate metabolism_Homo sapiens_hsa006401.91546903
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.90629491
17Longevity regulating pathway - mammal_Homo sapiens_hsa042111.86936294
18Butanoate metabolism_Homo sapiens_hsa006501.83356870
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73192232
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73121440
21Hepatitis C_Homo sapiens_hsa051601.72036147
22VEGF signaling pathway_Homo sapiens_hsa043701.70542368
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.68985309
24mTOR signaling pathway_Homo sapiens_hsa041501.68513613
25Synaptic vesicle cycle_Homo sapiens_hsa047211.63286019
26Taste transduction_Homo sapiens_hsa047421.63170307
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60506149
28Oxidative phosphorylation_Homo sapiens_hsa001901.60480499
29Fatty acid degradation_Homo sapiens_hsa000711.59011249
30Olfactory transduction_Homo sapiens_hsa047401.54826531
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54619056
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53057548
33Chronic myeloid leukemia_Homo sapiens_hsa052201.52177261
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51533603
35Gastric acid secretion_Homo sapiens_hsa049711.48966808
36ErbB signaling pathway_Homo sapiens_hsa040121.46968113
37Peroxisome_Homo sapiens_hsa041461.45287933
38Sulfur relay system_Homo sapiens_hsa041221.42428113
39Renal cell carcinoma_Homo sapiens_hsa052111.42184652
40Small cell lung cancer_Homo sapiens_hsa052221.41333373
41Tryptophan metabolism_Homo sapiens_hsa003801.34491299
42Fatty acid metabolism_Homo sapiens_hsa012121.34301332
43Insulin signaling pathway_Homo sapiens_hsa049101.33116927
44Estrogen signaling pathway_Homo sapiens_hsa049151.33065398
45Glioma_Homo sapiens_hsa052141.31428368
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31239827
47Glycerolipid metabolism_Homo sapiens_hsa005611.29978931
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28354445
49Melanoma_Homo sapiens_hsa052181.27800119
50Selenocompound metabolism_Homo sapiens_hsa004501.26683334
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23176025
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.22429842
53Pyruvate metabolism_Homo sapiens_hsa006201.21981063
54Axon guidance_Homo sapiens_hsa043601.17631243
55Other glycan degradation_Homo sapiens_hsa005111.15334506
56Rheumatoid arthritis_Homo sapiens_hsa053231.14675970
57Inositol phosphate metabolism_Homo sapiens_hsa005621.14361205
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12025685
59Renin secretion_Homo sapiens_hsa049241.08589152
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.08403945
61Lysine degradation_Homo sapiens_hsa003101.08182700
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03758805
63Fatty acid biosynthesis_Homo sapiens_hsa000610.98759466
64Endometrial cancer_Homo sapiens_hsa052130.97664345
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96702519
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92682051
67PPAR signaling pathway_Homo sapiens_hsa033200.89226876
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88547258
69Carbon metabolism_Homo sapiens_hsa012000.88072258
70Adherens junction_Homo sapiens_hsa045200.87413853
71beta-Alanine metabolism_Homo sapiens_hsa004100.86163519
72Fructose and mannose metabolism_Homo sapiens_hsa000510.82245666
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81472967
74Biosynthesis of amino acids_Homo sapiens_hsa012300.80659194
75Insulin resistance_Homo sapiens_hsa049310.80328225
76MicroRNAs in cancer_Homo sapiens_hsa052060.80117965
77AMPK signaling pathway_Homo sapiens_hsa041520.79852103
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79266096
79Bladder cancer_Homo sapiens_hsa052190.78706466
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.78313218
81Prolactin signaling pathway_Homo sapiens_hsa049170.77052187
82Colorectal cancer_Homo sapiens_hsa052100.76064472
83TNF signaling pathway_Homo sapiens_hsa046680.74878129
84Melanogenesis_Homo sapiens_hsa049160.73957434
85Salivary secretion_Homo sapiens_hsa049700.73805280
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73529500
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.73130578
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72660038
89Basal cell carcinoma_Homo sapiens_hsa052170.69686306
90Caffeine metabolism_Homo sapiens_hsa002320.68089021
91Tight junction_Homo sapiens_hsa045300.65025307
92Lysosome_Homo sapiens_hsa041420.63015195
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.62077090
94Ovarian steroidogenesis_Homo sapiens_hsa049130.62058499
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61506029
96Phenylalanine metabolism_Homo sapiens_hsa003600.61315378
97Focal adhesion_Homo sapiens_hsa045100.60774853
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60392286
99Pancreatic secretion_Homo sapiens_hsa049720.60255086
100Sphingolipid metabolism_Homo sapiens_hsa006000.60119025
101Glutathione metabolism_Homo sapiens_hsa004800.59387790
102N-Glycan biosynthesis_Homo sapiens_hsa005100.57624780
103FoxO signaling pathway_Homo sapiens_hsa040680.55992277
104Apoptosis_Homo sapiens_hsa042100.55911893
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55600399
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.55474087
107Pancreatic cancer_Homo sapiens_hsa052120.55435387
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54480507
109Hepatitis B_Homo sapiens_hsa051610.53809495
110Alzheimers disease_Homo sapiens_hsa050100.53770808
111Galactose metabolism_Homo sapiens_hsa000520.53159596
112Vitamin digestion and absorption_Homo sapiens_hsa049770.51777757
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51773378
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50913570
115Proteoglycans in cancer_Homo sapiens_hsa052050.50780643
116Pathways in cancer_Homo sapiens_hsa052000.50242009
117Prostate cancer_Homo sapiens_hsa052150.49943608
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.49740437
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48655973
120Endocytosis_Homo sapiens_hsa041440.48538225
121Thyroid hormone synthesis_Homo sapiens_hsa049180.48427758
122Steroid biosynthesis_Homo sapiens_hsa001000.48352660
123Vitamin B6 metabolism_Homo sapiens_hsa007500.48000953
124GnRH signaling pathway_Homo sapiens_hsa049120.47472637
125B cell receptor signaling pathway_Homo sapiens_hsa046620.47306043
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.46880432
127Renin-angiotensin system_Homo sapiens_hsa046140.46034213
128ECM-receptor interaction_Homo sapiens_hsa045120.44700034
129Salmonella infection_Homo sapiens_hsa051320.44390313
130Choline metabolism in cancer_Homo sapiens_hsa052310.44132081
131Protein digestion and absorption_Homo sapiens_hsa049740.43426757
132Parkinsons disease_Homo sapiens_hsa050120.43351556
133Histidine metabolism_Homo sapiens_hsa003400.42601852
134HIF-1 signaling pathway_Homo sapiens_hsa040660.42507984
135Toxoplasmosis_Homo sapiens_hsa051450.42132962
136Fatty acid elongation_Homo sapiens_hsa000620.41799402
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41771212
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41720518
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.41636098
140Phagosome_Homo sapiens_hsa041450.41489413
141Starch and sucrose metabolism_Homo sapiens_hsa005000.41117551
142Hippo signaling pathway_Homo sapiens_hsa043900.41048761
143Amoebiasis_Homo sapiens_hsa051460.39687872
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39639863
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.39521828
146Dilated cardiomyopathy_Homo sapiens_hsa054140.39473470
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.38312642
148Arginine and proline metabolism_Homo sapiens_hsa003300.38164010
149Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37081607
150Chemical carcinogenesis_Homo sapiens_hsa052040.37046924
151Folate biosynthesis_Homo sapiens_hsa007900.36791221
152Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36598766
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35001054
154Non-small cell lung cancer_Homo sapiens_hsa052230.34519496
155Dorso-ventral axis formation_Homo sapiens_hsa043200.33291391
156Pentose phosphate pathway_Homo sapiens_hsa000300.33184252
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32987602
158Glucagon signaling pathway_Homo sapiens_hsa049220.32564643
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32066008

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