FOXJ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.60385192
2negative regulation of muscle hypertrophy (GO:0014741)4.18800090
3positive regulation of myotube differentiation (GO:0010831)4.04810266
4polyketide metabolic process (GO:0030638)4.00002144
5doxorubicin metabolic process (GO:0044598)4.00002144
6daunorubicin metabolic process (GO:0044597)4.00002144
7negative regulation of potassium ion transmembrane transport (GO:1901380)3.91461986
8membrane raft organization (GO:0031579)3.89738265
9neutrophil activation involved in immune response (GO:0002283)3.84398734
10regulation of sarcomere organization (GO:0060297)3.83895447
11negative regulation of cardiac muscle hypertrophy (GO:0010614)3.80923202
12negative regulation of protein localization to cell surface (GO:2000009)3.80284485
13negative regulation of erythrocyte differentiation (GO:0045647)3.65647257
14negative regulation of nitric-oxide synthase activity (GO:0051001)3.61438692
15oxygen transport (GO:0015671)3.59959589
16positive regulation of histone deacetylation (GO:0031065)3.55679419
17positive regulation of gamma-delta T cell activation (GO:0046645)3.38644506
18maintenance of protein location in nucleus (GO:0051457)3.38569418
19germinal center formation (GO:0002467)3.21452542
20response to host (GO:0075136)3.12003650
21response to host defenses (GO:0052200)3.12003650
22response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.12003650
23regulation of ARF protein signal transduction (GO:0032012)3.03938591
24protein targeting to Golgi (GO:0000042)3.03091015
25positive regulation by symbiont of host defense response (GO:0052509)3.02624702
26modulation by symbiont of host defense response (GO:0052031)3.02624702
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02624702
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02624702
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.02624702
30modulation by symbiont of host immune response (GO:0052553)3.02624702
31plasma membrane repair (GO:0001778)3.01432246
32negative regulation of cardiac muscle tissue growth (GO:0055022)2.99966920
33negative regulation of heart growth (GO:0061117)2.99966920
34macrophage activation involved in immune response (GO:0002281)2.90870355
35striated muscle atrophy (GO:0014891)2.88890505
36negative regulation of cell killing (GO:0031342)2.86271493
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86271493
38cytidine catabolic process (GO:0006216)2.86261576
39cytidine deamination (GO:0009972)2.86261576
40cytidine metabolic process (GO:0046087)2.86261576
41gas transport (GO:0015669)2.85608509
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82564153
43retrograde transport, vesicle recycling within Golgi (GO:0000301)2.81754689
44positive regulation of granulocyte differentiation (GO:0030854)2.79467447
45positive regulation of protein deacetylation (GO:0090312)2.79415439
46synaptic vesicle maturation (GO:0016188)2.79118979
47positive regulation of macrophage cytokine production (GO:0060907)2.79116309
48establishment of protein localization to Golgi (GO:0072600)2.78798508
49antigen processing and presentation of endogenous antigen (GO:0019883)2.78668033
50sarcomere organization (GO:0045214)2.78448107
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78102419
52cardiac myofibril assembly (GO:0055003)2.77074215
53regulation of response to osmotic stress (GO:0047484)2.75022903
54neutrophil activation (GO:0042119)2.74558559
55B cell homeostasis (GO:0001782)2.73026765
56positive regulation of Rap GTPase activity (GO:0032854)2.72256313
57protein localization to endosome (GO:0036010)2.71310086
58myofibril assembly (GO:0030239)2.71298736
59cellular extravasation (GO:0045123)2.71116226
60establishment of endothelial barrier (GO:0061028)2.70206581
61regulation of gamma-delta T cell activation (GO:0046643)2.69471247
62interferon-gamma production (GO:0032609)2.67632826
63negative regulation of monooxygenase activity (GO:0032769)2.63657776
64detection of other organism (GO:0098543)2.61475078
65positive regulation of extracellular matrix organization (GO:1903055)2.60732726
66leukocyte aggregation (GO:0070486)2.60708389
67regulation of gamma-delta T cell differentiation (GO:0045586)2.60354181
68nerve growth factor signaling pathway (GO:0038180)2.58341448
69response to muramyl dipeptide (GO:0032495)2.57486320
70proline transport (GO:0015824)2.52253870
71detection of bacterium (GO:0016045)2.51207895
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50677008
73response to peptidoglycan (GO:0032494)2.50015185
74hormone catabolic process (GO:0042447)2.48261863
75positive regulation of myoblast differentiation (GO:0045663)2.47522445
76somite rostral/caudal axis specification (GO:0032525)2.47326445
77granulocyte activation (GO:0036230)2.47222751
78aminoglycoside antibiotic metabolic process (GO:0030647)2.46464897
79muscle organ morphogenesis (GO:0048644)2.45351650
80regulation of transforming growth factor beta2 production (GO:0032909)2.45100732
81mitochondrion distribution (GO:0048311)2.44957244
82regulation of Rap GTPase activity (GO:0032317)2.44357199
83negative thymic T cell selection (GO:0045060)2.43694357
84SMAD protein complex assembly (GO:0007183)2.43425972
85response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.42831711
86ovulation cycle (GO:0042698)2.42331731
87retinoic acid receptor signaling pathway (GO:0048384)2.42220897
88regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.41920854
89regulation of MHC class I biosynthetic process (GO:0045343)2.40282552
90activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.38453394
91myoblast fusion (GO:0007520)2.38061251
92syncytium formation by plasma membrane fusion (GO:0000768)2.36828960
93cytoskeletal anchoring at plasma membrane (GO:0007016)2.36777814
94regulation of cardiac muscle cell differentiation (GO:2000725)2.36161156
95bone trabecula formation (GO:0060346)2.35575054
96hemoglobin metabolic process (GO:0020027)2.34985746
97negative T cell selection (GO:0043383)2.33084917
98platelet formation (GO:0030220)2.32791557
99T cell homeostasis (GO:0043029)2.32477943
100response to host immune response (GO:0052572)2.32416917
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.32416917
102positive regulation of fibroblast migration (GO:0010763)2.31748589
103pericardium development (GO:0060039)2.31539556
104positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.31009143
105regulation of muscle hypertrophy (GO:0014743)2.30838551
106regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.30389930
107calcium-mediated signaling using intracellular calcium source (GO:0035584)2.30083646
108muscle atrophy (GO:0014889)2.29684750
109negative regulation of bone resorption (GO:0045779)2.29682207
110regulation of p38MAPK cascade (GO:1900744)2.29452659
111negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.29230085
112phenol-containing compound catabolic process (GO:0019336)2.29066965
113regulation of B cell receptor signaling pathway (GO:0050855)2.27824944
114hypotonic response (GO:0006971)2.27781217
115detection of temperature stimulus (GO:0016048)2.27750358
116regulation of platelet aggregation (GO:0090330)2.27478857
117positive regulation of microtubule polymerization (GO:0031116)2.27421374
118negative regulation of T-helper cell differentiation (GO:0045623)2.27023256
119negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.27023256
120cellular response to fluid shear stress (GO:0071498)2.26645700
121regulation of T-helper 2 cell differentiation (GO:0045628)2.26182283
122positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.25806316
123skeletal muscle adaptation (GO:0043501)2.24725971
124skeletal muscle tissue regeneration (GO:0043403)2.24213726
125adaptation of signaling pathway (GO:0023058)2.24087975
126lymphocyte homeostasis (GO:0002260)2.23696046
127regulation of glucose import in response to insulin stimulus (GO:2001273)2.23350194
128sarcoplasmic reticulum calcium ion transport (GO:0070296)2.21692683
129apoptotic cell clearance (GO:0043277)2.21587346
130response to dietary excess (GO:0002021)2.21517832
131pyrimidine ribonucleoside catabolic process (GO:0046133)2.20559859
132embryonic process involved in female pregnancy (GO:0060136)2.20144229
133regulation of germinal center formation (GO:0002634)2.17371655
134response to laminar fluid shear stress (GO:0034616)2.17088444
135muscle filament sliding (GO:0030049)2.17007389
136actin-myosin filament sliding (GO:0033275)2.17007389
137T cell selection (GO:0045058)2.16993192
138regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.15994246
139positive regulation of blood vessel endothelial cell migration (GO:0043536)2.15950498
140tolerance induction (GO:0002507)2.15704352
141detection of external biotic stimulus (GO:0098581)2.15125383
142negative regulation of organelle assembly (GO:1902116)2.15062507
143cardiac muscle cell proliferation (GO:0060038)2.13532400
144creatine metabolic process (GO:0006600)2.12960968
145regulation of macrophage cytokine production (GO:0010935)2.12949064
146regulation of actin filament-based movement (GO:1903115)2.11056029
147regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.09928310
148endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.09193108
149branching involved in mammary gland duct morphogenesis (GO:0060444)2.08847569
150Rap protein signal transduction (GO:0032486)2.07264110
151potassium ion import (GO:0010107)2.06089974
152histone H4-K16 acetylation (GO:0043984)2.05557177
153phosphatidylinositol 3-kinase signaling (GO:0014065)2.05511554
154negative regulation of cell size (GO:0045792)2.03948146
155regulation of skeletal muscle contraction (GO:0014819)2.03049053
156positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.01432650
157icosanoid secretion (GO:0032309)2.01048863
158arachidonic acid secretion (GO:0050482)2.01048863
159positive regulation of odontogenesis (GO:0042482)1.99475524
160cellular response to nerve growth factor stimulus (GO:1990090)1.99139715
161response to nerve growth factor (GO:1990089)1.99139715
162regulation of histone deacetylation (GO:0031063)1.98949805
163negative regulation of potassium ion transport (GO:0043267)1.98875087
164regulation of alkaline phosphatase activity (GO:0010692)1.98818278
165regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)1.98673687
166cell communication by electrical coupling involved in cardiac conduction (GO:0086064)1.97758413
167mitochondrion localization (GO:0051646)1.97667669
168histone H4-K5 acetylation (GO:0043981)1.97422381
169histone H4-K8 acetylation (GO:0043982)1.97422381
170negative regulation of bone remodeling (GO:0046851)1.97012919
171negative regulation of viral release from host cell (GO:1902187)1.96285474
172negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.94604175
173NLS-bearing protein import into nucleus (GO:0006607)1.94475050
174ventricular cardiac muscle tissue morphogenesis (GO:0055010)1.94392075
175relaxation of cardiac muscle (GO:0055119)1.94135704
176stress fiber assembly (GO:0043149)1.94125237
177regulation of cell communication by electrical coupling (GO:0010649)1.92877176
178regulation of ARF GTPase activity (GO:0032312)1.91648488
179regulation of mammary gland epithelial cell proliferation (GO:0033599)1.91072136
180histone H3-K4 methylation (GO:0051568)1.90840843
181regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)1.90302925
182actomyosin structure organization (GO:0031032)1.90092251
183adult heart development (GO:0007512)1.89097760
184positive thymic T cell selection (GO:0045059)1.89055388
185natural killer cell differentiation (GO:0001779)1.88473887
186cardiac muscle contraction (GO:0060048)1.88397792
187positive regulation of axon extension (GO:0045773)1.88333147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.28533904
2EGR1_19374776_ChIP-ChIP_THP-1_Human2.75654687
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.74740988
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.61090710
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42411709
6* KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.28999627
7* KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.28999627
8* KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.28999627
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20091890
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.07832393
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05333380
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97404622
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94416401
14VDR_24763502_ChIP-Seq_THP-1_Human1.87821134
15MYC_22102868_ChIP-Seq_BL_Human1.86246599
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83394680
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.82558067
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81406666
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77678015
20GATA1_22025678_ChIP-Seq_K562_Human1.76776471
21KDM2B_26808549_Chip-Seq_K562_Human1.76234546
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74465246
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71196351
24VDR_21846776_ChIP-Seq_THP-1_Human1.68904445
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66273555
26TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.62738149
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61906158
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59093685
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59014978
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.58625865
31MAF_26560356_Chip-Seq_TH1_Human1.55003609
32GATA1_19941827_ChIP-Seq_MEL_Mouse1.54030391
33* FOXO3_23340844_ChIP-Seq_DLD1_Human1.52979704
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51828558
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51828558
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.51519455
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49732698
38KDM2B_26808549_Chip-Seq_DND41_Human1.48678521
39* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47772083
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.45592392
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45457188
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45061292
43* UTX_26944678_Chip-Seq_JUKART_Human1.44824859
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44020428
45GATA2_19941826_ChIP-Seq_K562_Human1.44008775
46VDR_24787735_ChIP-Seq_THP-1_Human1.40744240
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38507846
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37648684
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37219376
50AHR_22903824_ChIP-Seq_MCF-7_Human1.36868036
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34965171
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.34410100
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34051488
54DROSHA_22980978_ChIP-Seq_HELA_Human1.33457061
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32421791
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32264117
57* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32153112
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32053438
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31678612
60* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31006592
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29598518
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29574970
63CDX2_20551321_ChIP-Seq_CACO-2_Human1.28590024
64RUNX_20019798_ChIP-Seq_JUKART_Human1.27841455
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27263383
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27065609
67TP63_17297297_ChIP-ChIP_HaCaT_Human1.26760371
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.24910138
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.24910138
70MYB_26560356_Chip-Seq_TH2_Human1.24351827
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.24346753
72LXR_22292898_ChIP-Seq_THP-1_Human1.23710563
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23472967
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22536634
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21239129
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20622932
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.20228788
78* ELK3_25401928_ChIP-Seq_HUVEC_Human1.20128289
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.19843152
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19491728
81* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19249196
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18313576
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18257099
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.17512526
85* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17075491
86* RARB_27405468_Chip-Seq_BRAIN_Mouse1.17065924
87* SPI1_23127762_ChIP-Seq_K562_Human1.16781174
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15535975
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.14944626
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14040750
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13843460
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13668883
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.13645754
94* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11807322
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11703999
96GATA1_19941827_ChIP-Seq_MEL86_Mouse1.10409419
97SCL_19346495_ChIP-Seq_HPC-7_Human1.09470009
98GATA3_27048872_Chip-Seq_THYMUS_Human1.09049201
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08199845
100JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08046026
101GATA1_19941826_ChIP-Seq_K562_Human1.07215929
102* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06664660
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06658592
104MYB_26560356_Chip-Seq_TH1_Human1.05707637
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05659831
106SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05292879
107RACK7_27058665_Chip-Seq_MCF-7_Human1.05224914
108EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04058066
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.02249558
110RUNX1_27514584_Chip-Seq_MCF-7_Human1.02019802
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01221475
112MAF_26560356_Chip-Seq_TH2_Human1.01071602
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00585803
114HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00240789
115IRF8_21731497_ChIP-ChIP_J774_Mouse0.99271847
116* RING1B_27294783_Chip-Seq_NPCs_Mouse0.98412364
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98115979
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96716265
119NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95762155
120EZH2_22144423_ChIP-Seq_EOC_Human0.95448511
121SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95278947
122SPI1_23547873_ChIP-Seq_NB4_Human0.94853580
123* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94323176
124* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92969867
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92922577
126SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92766967
127* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92765181
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91859476
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91632608
130* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90787883
131EZH2_27304074_Chip-Seq_ESCs_Mouse0.90429413
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90099264
133IRF8_27001747_Chip-Seq_BMDM_Mouse0.88952677
134PU_27001747_Chip-Seq_BMDM_Mouse0.88148308
135JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88140577
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.88084610
137KLF5_25053715_ChIP-Seq_YYC3_Human0.87881696
138* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87738333
139SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87575843
140GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87052833
141PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86627134
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86622849
143WT1_19549856_ChIP-ChIP_CCG9911_Human0.85590825
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85541541
145RXR_22108803_ChIP-Seq_LS180_Human0.85334283
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84951447
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.84071146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.85586763
2MP0004858_abnormal_nervous_system3.06786270
3MP0003705_abnormal_hypodermis_morpholog2.95228521
4MP0002837_dystrophic_cardiac_calcinosis2.87897760
5MP0003436_decreased_susceptibility_to2.53148125
6MP0000749_muscle_degeneration2.40361689
7MP0004510_myositis2.38178565
8MP0000751_myopathy2.21155251
9MP0003763_abnormal_thymus_physiology2.17365627
10MP0002332_abnormal_exercise_endurance2.14929561
11MP0004084_abnormal_cardiac_muscle2.14002046
12MP0008438_abnormal_cutaneous_collagen2.11018010
13MP0008961_abnormal_basal_metabolism2.10432303
14MP0003724_increased_susceptibility_to2.06450216
15MP0003191_abnormal_cellular_cholesterol2.03691126
16MP0001958_emphysema1.98834278
17MP0004087_abnormal_muscle_fiber1.97691062
18MP0003045_fibrosis1.94616481
19MP0000685_abnormal_immune_system1.94559592
20MP0005623_abnormal_meninges_morphology1.94425305
21MP0003828_pulmonary_edema1.88136890
22MP0005451_abnormal_body_composition1.81492289
23MP0004215_abnormal_myocardial_fiber1.80692774
24MP0005257_abnormal_intraocular_pressure1.80364396
25MP0004264_abnormal_extraembryonic_tissu1.77920647
26MP0003011_delayed_dark_adaptation1.76710695
27MP0003137_abnormal_impulse_conducting1.74100009
28MP0004036_abnormal_muscle_relaxation1.72981262
29MP0005330_cardiomyopathy1.71075739
30MP0008260_abnormal_autophagy1.70887389
31MP0006082_CNS_inflammation1.70455851
32MP0004185_abnormal_adipocyte_glucose1.70389494
33MP0004145_abnormal_muscle_electrophysio1.64534615
34MP0003950_abnormal_plasma_membrane1.64096151
35MP0009278_abnormal_bone_marrow1.63958458
36MP0003300_gastrointestinal_ulcer1.62945861
37MP0001835_abnormal_antigen_presentation1.62456443
38MP0005275_abnormal_skin_tensile1.60143234
39MP0000750_abnormal_muscle_regeneration1.59641362
40MP0010630_abnormal_cardiac_muscle1.59252154
41MP0004947_skin_inflammation1.59172963
42MP0002419_abnormal_innate_immunity1.58982285
43MP0000759_abnormal_skeletal_muscle1.58918825
44MP0005464_abnormal_platelet_physiology1.58316596
45MP0002972_abnormal_cardiac_muscle1.53414809
46MP0005670_abnormal_white_adipose1.49799725
47MP0002877_abnormal_melanocyte_morpholog1.47794644
48MP0010368_abnormal_lymphatic_system1.47133100
49MP0001533_abnormal_skeleton_physiology1.46019506
50MP0003303_peritoneal_inflammation1.44844908
51MP0008004_abnormal_stomach_pH1.44384495
52MP0002106_abnormal_muscle_physiology1.41054853
53MP0005025_abnormal_response_to1.39429838
54MP0005620_abnormal_muscle_contractility1.38235518
55MP0004085_abnormal_heartbeat1.36880272
56MP0009780_abnormal_chondrocyte_physiolo1.36308693
57MP0004130_abnormal_muscle_cell1.34950080
58MP0002127_abnormal_cardiovascular_syste1.32618168
59MP0003656_abnormal_erythrocyte_physiolo1.31719772
60MP0002269_muscular_atrophy1.30048780
61MP0000920_abnormal_myelination1.28302037
62MP0003183_abnormal_peptide_metabolism1.28111498
63MP0005394_taste/olfaction_phenotype1.28105725
64MP0005499_abnormal_olfactory_system1.28105725
65MP0001800_abnormal_humoral_immune1.26553077
66MP0002909_abnormal_adrenal_gland1.25430481
67MP0005369_muscle_phenotype1.22957648
68MP0003566_abnormal_cell_adhesion1.22341388
69MP0004484_altered_response_of1.20681268
70MP0001348_abnormal_lacrimal_gland1.20443229
71MP0004859_abnormal_synaptic_plasticity1.20398036
72MP0002723_abnormal_immune_serum1.19658254
73MP0001790_abnormal_immune_system1.19190947
74MP0005387_immune_system_phenotype1.19190947
75MP0002420_abnormal_adaptive_immunity1.18931071
76MP0004043_abnormal_pH_regulation1.18376988
77MP0005666_abnormal_adipose_tissue1.17592861
78MP0006138_congestive_heart_failure1.16874267
79MP0000747_muscle_weakness1.15914258
80MP0001819_abnormal_immune_cell1.15799398
81MP0003091_abnormal_cell_migration1.15614112
82MP0010352_gastrointestinal_tract_polyps1.14610581
83MP0003453_abnormal_keratinocyte_physiol1.14000622
84MP0004272_abnormal_basement_membrane1.13959846
85MP0002933_joint_inflammation1.13863954
86MP0002452_abnormal_antigen_presenting1.12917582
87MP0009785_altered_susceptibility_to1.11368294
88MP0004883_abnormal_blood_vessel1.11321218
89MP0008775_abnormal_heart_ventricle1.10671286
90MP0002398_abnormal_bone_marrow1.09253062
91MP0003690_abnormal_glial_cell1.09215978
92MP0001545_abnormal_hematopoietic_system1.09212955
93MP0005397_hematopoietic_system_phenotyp1.09212955
94MP0002405_respiratory_system_inflammati1.08212762
95MP0005375_adipose_tissue_phenotype1.06616401
96MP0003122_maternal_imprinting1.06293902
97MP0000858_altered_metastatic_potential1.04598558
98MP0000678_abnormal_parathyroid_gland1.04411058
99MP0005385_cardiovascular_system_phenoty1.03246322
100MP0001544_abnormal_cardiovascular_syste1.03246322
101MP0002796_impaired_skin_barrier1.00599051
102MP0003279_aneurysm1.00580258
103MP0001879_abnormal_lymphatic_vessel1.00528164
104MP0003221_abnormal_cardiomyocyte_apopto0.99688109
105MP0000465_gastrointestinal_hemorrhage0.99222313
106MP0002925_abnormal_cardiovascular_devel0.99126561
107MP0000703_abnormal_thymus_morphology0.98820113
108MP0001873_stomach_inflammation0.98145236
109MP0003075_altered_response_to0.96542931
110MP0005023_abnormal_wound_healing0.95591873
111MP0000716_abnormal_immune_system0.94335902
112MP0005671_abnormal_response_to0.92971198
113MP0000733_abnormal_muscle_development0.92537533
114MP0004270_analgesia0.91631159
115MP0005503_abnormal_tendon_morphology0.91504915
116MP0002148_abnormal_hypersensitivity_rea0.90565705
117MP0002108_abnormal_muscle_morphology0.90104237
118MP0005058_abnormal_lysosome_morphology0.89035553
119MP0000383_abnormal_hair_follicle0.88274657
120MP0005390_skeleton_phenotype0.88222177
121MP0002009_preneoplasia0.86784154
122MP0010678_abnormal_skin_adnexa0.86663411
123MP0005164_abnormal_response_to0.86580597
124MP0001851_eye_inflammation0.86515068
125MP0002722_abnormal_immune_system0.86187041
126MP0000343_altered_response_to0.84660143
127MP0005409_darkened_coat_color0.84536391
128MP0005388_respiratory_system_phenotype0.83266814
129MP0002133_abnormal_respiratory_system0.83266814
130MP0002396_abnormal_hematopoietic_system0.82752362
131MP0003634_abnormal_glial_cell0.80751532
132MP0000003_abnormal_adipose_tissue0.79583610
133MP0000767_abnormal_smooth_muscle0.77991589
134MP0000266_abnormal_heart_morphology0.76024565
135MP0005310_abnormal_salivary_gland0.75824024
136MP0003172_abnormal_lysosome_physiology0.74598333
137MP0003646_muscle_fatigue0.73792274
138MP0002090_abnormal_vision0.73400833
139MP0005167_abnormal_blood-brain_barrier0.73343348
140MP0001849_ear_inflammation0.73311969
141MP0008874_decreased_physiological_sensi0.71717776
142MP0006035_abnormal_mitochondrial_morpho0.70421512
143MP0000013_abnormal_adipose_tissue0.70216795
144MP0003890_abnormal_embryonic-extraembry0.69596503
145MP0002277_abnormal_respiratory_mucosa0.69041409
146MP0005000_abnormal_immune_tolerance0.68567192
147MP0005076_abnormal_cell_differentiation0.67096521
148MP0002998_abnormal_bone_remodeling0.66875891
149MP0004381_abnormal_hair_follicle0.66527104
150MP0000762_abnormal_tongue_morphology0.66101711
151MP0000428_abnormal_craniofacial_morphol0.66065703
152MP0008569_lethality_at_weaning0.64087712
153MP0005075_abnormal_melanosome_morpholog0.62129150

Predicted human phenotypes

RankGene SetZ-score
1Difficulty running (HP:0009046)4.81537816
2Bilateral microphthalmos (HP:0007633)4.34617198
3Increased connective tissue (HP:0009025)4.13740387
4Ventricular tachycardia (HP:0004756)3.96027305
5Hyporeflexia of lower limbs (HP:0002600)3.72017380
6Distal lower limb muscle weakness (HP:0009053)3.53904431
7Sudden death (HP:0001699)3.51331920
8Hepatoblastoma (HP:0002884)3.47965902
9Arterial tortuosity (HP:0005116)3.39054918
10Obstructive sleep apnea (HP:0002870)3.37306389
11Exercise-induced muscle cramps (HP:0003710)3.19899310
12Vascular tortuosity (HP:0004948)3.19509800
13Nemaline bodies (HP:0003798)3.17831069
14EMG: myopathic abnormalities (HP:0003458)3.15912311
15Neck muscle weakness (HP:0000467)3.10607961
16Aortic aneurysm (HP:0004942)3.08417142
17Increased variability in muscle fiber diameter (HP:0003557)3.07652462
18Mildly elevated creatine phosphokinase (HP:0008180)3.06222130
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.99401789
20Muscle fiber inclusion bodies (HP:0100299)2.97208490
21Protrusio acetabuli (HP:0003179)2.96015589
22Eczematoid dermatitis (HP:0000976)2.94897472
23Testicular atrophy (HP:0000029)2.94829457
24Atrial fibrillation (HP:0005110)2.90196090
25Muscle hypertrophy of the lower extremities (HP:0008968)2.88641585
26Calf muscle hypertrophy (HP:0008981)2.88199663
27Abnormality of the lower motor neuron (HP:0002366)2.85771365
28Muscle fiber splitting (HP:0003555)2.84261769
29Hypochromic microcytic anemia (HP:0004840)2.81901539
30Primary atrial arrhythmia (HP:0001692)2.80239021
31Achilles tendon contracture (HP:0001771)2.75151944
32Spondylolisthesis (HP:0003302)2.71790285
33Periauricular skin pits (HP:0100277)2.68777734
34Preauricular pit (HP:0004467)2.68777734
35Abnormality of skeletal muscle fiber size (HP:0012084)2.65912061
36Muscle stiffness (HP:0003552)2.65597295
37Exercise-induced myalgia (HP:0003738)2.65417862
38Abnormality of the left ventricular outflow tract (HP:0011103)2.64049867
39Subaortic stenosis (HP:0001682)2.64049867
40Prolonged bleeding time (HP:0003010)2.63680932
41Multiple enchondromatosis (HP:0005701)2.62151747
42Hyperinsulinemic hypoglycemia (HP:0000825)2.61436621
43Aortic dissection (HP:0002647)2.60877269
44Abnormality of the calf musculature (HP:0001430)2.60052858
45Increased IgE level (HP:0003212)2.59068626
46Supraventricular tachycardia (HP:0004755)2.56116768
47Neoplasm of the heart (HP:0100544)2.55287087
48Supraventricular arrhythmia (HP:0005115)2.53067335
49Macroorchidism (HP:0000053)2.43756217
50Distal upper limb amyotrophy (HP:0007149)2.42455560
51Upper limb amyotrophy (HP:0009129)2.42455560
52Spontaneous hematomas (HP:0007420)2.41722357
53Abnormality of the salivary glands (HP:0010286)2.41371491
54Right ventricular cardiomyopathy (HP:0011663)2.38094956
55Distal lower limb amyotrophy (HP:0008944)2.36886707
56Skin pits (HP:0100276)2.36792619
57Abnormality of the Achilles tendon (HP:0005109)2.34884945
58Rapidly progressive (HP:0003678)2.34828345
59Gowers sign (HP:0003391)2.32939192
60Myositis (HP:0100614)2.28242904
61Hypoplasia of the thymus (HP:0000778)2.24934192
62Rib fusion (HP:0000902)2.24650224
63Lower limb amyotrophy (HP:0007210)2.23190102
64Cerebral aneurysm (HP:0004944)2.22530901
65Round ear (HP:0100830)2.21065946
66Scapular winging (HP:0003691)2.18810559
67Myotonia (HP:0002486)2.17052743
68EMG: neuropathic changes (HP:0003445)2.16025782
69Broad metatarsal (HP:0001783)2.15688447
70Difficulty climbing stairs (HP:0003551)2.13864211
71Papilledema (HP:0001085)2.12620256
72Sensory axonal neuropathy (HP:0003390)2.11742418
73Abnormal hemoglobin (HP:0011902)2.11520493
74Ulnar deviation of the wrist (HP:0003049)2.10914201
75Syncope (HP:0001279)2.09905747
76Areflexia of lower limbs (HP:0002522)2.05952040
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05624096
78Centrally nucleated skeletal muscle fibers (HP:0003687)2.03634412
79Orchitis (HP:0100796)2.03579109
80Abnormality of glycolipid metabolism (HP:0010969)2.03307492
81Abnormality of liposaccharide metabolism (HP:0010968)2.03307492
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.03307492
83Recurrent abscess formation (HP:0002722)2.02566912
84Dilatation of the ascending aorta (HP:0005111)2.01573352
85Lymphangioma (HP:0100764)2.00843074
86Myopathic facies (HP:0002058)2.00190286
87Abnormal delayed hypersensitivity skin test (HP:0002963)1.97827217
88Overgrowth (HP:0001548)1.97826480
89Difficulty walking (HP:0002355)1.96940021
90Mitral valve prolapse (HP:0001634)1.96833243
91Asymmetric septal hypertrophy (HP:0001670)1.96628173
92Hand muscle atrophy (HP:0009130)1.96002116
93Easy fatigability (HP:0003388)1.95601857
94Ventricular arrhythmia (HP:0004308)1.94299487
95Abnormality of macrophages (HP:0004311)1.94288878
96Elevated erythrocyte sedimentation rate (HP:0003565)1.93664102
97Open mouth (HP:0000194)1.92305339
98Slender build (HP:0001533)1.91765933
99Neurofibrillary tangles (HP:0002185)1.90938943
100Prolonged QT interval (HP:0001657)1.90108713
101Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89975174
102Abnormality of the heme biosynthetic pathway (HP:0010472)1.89965713
103Abnormality of the fingertips (HP:0001211)1.89254924
104Mitral regurgitation (HP:0001653)1.87891143
105Amblyopia (HP:0000646)1.87823430
106Supranuclear gaze palsy (HP:0000605)1.87397298
107Cellulitis (HP:0100658)1.86912892
108Hyperventilation (HP:0002883)1.86534959
109Generalized hypotonia (HP:0001290)1.86325998
110Abnormality of the pubic bones (HP:0003172)1.84786805
111Hamartoma of the eye (HP:0010568)1.84576208
112Disproportionate tall stature (HP:0001519)1.84433162
113Abnormality of the musculature of the hand (HP:0001421)1.83557911
114Intestinal fistula (HP:0100819)1.82263325
115Gastrointestinal infarctions (HP:0005244)1.82262941
116Recurrent bacterial skin infections (HP:0005406)1.81892619
117Premature rupture of membranes (HP:0001788)1.81358867
118Cerebral inclusion bodies (HP:0100314)1.80932482
119Peritonitis (HP:0002586)1.80681020
120Bundle branch block (HP:0011710)1.79512627
121Aortic regurgitation (HP:0001659)1.79420149
122Resting tremor (HP:0002322)1.79239608
123Abnormal platelet volume (HP:0011876)1.79194356
124Type 1 muscle fiber predominance (HP:0003803)1.77911476
125Onion bulb formation (HP:0003383)1.77233603
126Optic neuritis (HP:0100653)1.76148373
127Retrobulbar optic neuritis (HP:0100654)1.76148373
128Skin nodule (HP:0200036)1.74158559
129Bruising susceptibility (HP:0000978)1.72068294
130Ankle clonus (HP:0011448)1.71995073
131Aneurysm (HP:0002617)1.71850687
132Partial duplication of thumb phalanx (HP:0009944)1.70650530
133Recurrent fungal infections (HP:0002841)1.70362412
134Bradycardia (HP:0001662)1.69883826
135Amyotrophic lateral sclerosis (HP:0007354)1.69805124
136Epistaxis (HP:0000421)1.69529046
137Dislocated radial head (HP:0003083)1.69088739
138Urticaria (HP:0001025)1.68912159
139Abnormality of the corticospinal tract (HP:0002492)1.67993479
140Thin bony cortex (HP:0002753)1.67113905
141Cubitus valgus (HP:0002967)1.67041860
142Chest pain (HP:0100749)1.66013036
143Gingivitis (HP:0000230)1.63940157
144Horizontal nystagmus (HP:0000666)1.63853675
145Neuronal loss in central nervous system (HP:0002529)1.63815056
146Visceral angiomatosis (HP:0100761)1.63491184
147Skin tags (HP:0010609)1.63312237
148Abnormality of the nasal mucosa (HP:0000433)1.62677321
149Lipoatrophy (HP:0100578)1.62557339
150Fused cervical vertebrae (HP:0002949)1.62344766
151Dysmetric saccades (HP:0000641)1.59795256
152Spinal rigidity (HP:0003306)1.59197858
153Stomatitis (HP:0010280)1.59014048
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.58802057
155Pustule (HP:0200039)1.58314076
156Spinal cord lesions (HP:0100561)1.57728995
157Syringomyelia (HP:0003396)1.57728995
158Turricephaly (HP:0000262)1.57428571
159Abnormality of the radial head (HP:0003995)1.55868452
160Preauricular skin tag (HP:0000384)1.55506500
161Broad face (HP:0000283)1.55155802
162Abnormal EKG (HP:0003115)1.54786403
163Fragile skin (HP:0001030)1.53572406
164Granulocytopenia (HP:0001913)1.52405560
165Recurrent gram-negative bacterial infections (HP:0005420)1.52221623
166Meningitis (HP:0001287)1.51714038
167Gingival bleeding (HP:0000225)1.51447223
168Increased mean platelet volume (HP:0011877)1.48982941
169Polycythemia (HP:0001901)1.48342435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.90591572
2ERN13.83801399
3GRK53.27426174
4PRPF4B3.25835688
5TGFBR22.82808979
6GRK62.66976025
7MAP2K32.51895967
8MUSK2.26217873
9WNK12.25602427
10EPHB12.21847870
11PIK3CG2.14752804
12TTN2.11095624
13GRK71.97460130
14TYRO31.91352320
15CSF1R1.82485731
16GRK11.79150488
17TRIB31.75561830
18STK101.72493473
19MAPKAPK51.72150452
20DMPK1.68734607
21RIPK11.67082486
22SIK31.66832997
23MAPK71.64608430
24ZAP701.60312681
25MARK21.57417841
26NTRK11.48334728
27FGFR31.44410529
28ADRBK21.42534039
29MAP3K61.40743563
30TNK21.36038749
31MAP3K71.35903402
32MAP3K31.31021214
33CAMK41.29784826
34RIPK41.29303389
35SIK21.28510441
36HIPK21.25801148
37IRAK41.22135071
38CAMK1G1.21047308
39MAPK121.20743964
40MOS1.20255098
41PHKG21.19239665
42PHKG11.19239665
43CDK81.17795378
44CSK1.09734125
45MAP4K11.07452490
46SIK11.07349849
47JAK31.06044100
48AKT31.04682480
49PDGFRA1.03885842
50BLK1.03635788
51ITK1.02919419
52PRKCH1.02660138
53MAP3K131.02629258
54MAP3K101.01794046
55MAP3K141.00168838
56SMG10.96064498
57SYK0.95622463
58MATK0.95261165
59PIK3CA0.94567039
60JAK10.94310246
61PAK30.94040139
62SCYL20.93777484
63BTK0.93212822
64MARK30.92349683
65CAMK1D0.91870307
66PRKD10.89544871
67NLK0.89189280
68PTK20.87037161
69PKN10.86324363
70PTK60.84359431
71TAOK20.80130660
72PRKD20.79336727
73CDK90.77648029
74TXK0.77286803
75TRPM70.77094388
76HCK0.75518792
77YES10.75298851
78MELK0.75163043
79FES0.74875087
80ALK0.74560404
81PRKG20.72907398
82SGK20.72120222
83IKBKE0.70352888
84LMTK20.69481453
85MAP3K110.69380837
86ADRBK10.68770009
87STK110.68183612
88MAP2K40.67561723
89PDGFRB0.66528593
90MAP3K90.65124404
91ICK0.63363658
92MYLK0.62845199
93OBSCN0.60938282
94MTOR0.60931778
95CDK40.60883502
96BRD40.60769740
97EEF2K0.60461718
98RPS6KA20.60238617
99TBK10.59668733
100EPHA30.58931130
101TAOK10.58663051
102MAPK40.58374665
103LCK0.57929986
104BMX0.52509952
105CDC42BPA0.51978172
106FGR0.50323512
107FGFR20.49243675
108RPS6KL10.49145717
109RPS6KC10.49145717
110KSR20.48984874
111PAK60.48925389
112PRKD30.48118629
113JAK20.48043318
114PRKCQ0.47829337
115MAP3K10.46959888
116PAK40.46870389
117PDK10.45843253
118INSRR0.45755772
119INSR0.45646673
120FYN0.44764772
121TYK20.44090074
122WNK40.43536154
123MAP3K20.42807223
124STK380.42748445
125IGF1R0.42445429
126PTK2B0.42068297
127SGK30.40703755
128RET0.37699643
129PDPK10.36684581
130PRKAA20.36018585
131CAMK10.35602238
132STK390.35303958
133IKBKB0.35142667
134ROCK20.35110486
135NTRK20.34683760
136FGFR40.34461552
137PRKAA10.33731658
138DAPK20.33499100
139GSK3A0.33063677
140CDK50.32860397
141SRC0.32737859
142LRRK20.29587398
143PKN20.28817696

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.41297157
2Dilated cardiomyopathy_Homo sapiens_hsa054141.93570695
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75121528
4Chronic myeloid leukemia_Homo sapiens_hsa052201.73672251
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.57499371
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54238849
7Malaria_Homo sapiens_hsa051441.44433902
8Dorso-ventral axis formation_Homo sapiens_hsa043201.43612643
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39668683
10Endometrial cancer_Homo sapiens_hsa052131.35896130
11Renin secretion_Homo sapiens_hsa049241.33490248
12B cell receptor signaling pathway_Homo sapiens_hsa046621.29476342
13Colorectal cancer_Homo sapiens_hsa052101.28899605
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27775837
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27620950
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27213592
17Phospholipase D signaling pathway_Homo sapiens_hsa040721.24112699
18Glutamatergic synapse_Homo sapiens_hsa047241.20456062
19mTOR signaling pathway_Homo sapiens_hsa041501.18685656
20FoxO signaling pathway_Homo sapiens_hsa040681.18615674
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18388291
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18345147
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16872173
24TNF signaling pathway_Homo sapiens_hsa046681.16858645
25Hepatitis B_Homo sapiens_hsa051611.15184722
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14369104
27Oxytocin signaling pathway_Homo sapiens_hsa049211.13910943
28Long-term potentiation_Homo sapiens_hsa047201.13436635
29VEGF signaling pathway_Homo sapiens_hsa043701.12527788
30GnRH signaling pathway_Homo sapiens_hsa049121.10848006
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10364918
32Gastric acid secretion_Homo sapiens_hsa049711.10358246
33Measles_Homo sapiens_hsa051621.08069440
34Osteoclast differentiation_Homo sapiens_hsa043801.08000367
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.06979816
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06968943
37Salivary secretion_Homo sapiens_hsa049701.05653954
38Insulin resistance_Homo sapiens_hsa049311.05089027
39cAMP signaling pathway_Homo sapiens_hsa040241.04783911
40Prolactin signaling pathway_Homo sapiens_hsa049171.03178625
41GABAergic synapse_Homo sapiens_hsa047271.02181583
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.01997840
43Type II diabetes mellitus_Homo sapiens_hsa049301.01757093
44Focal adhesion_Homo sapiens_hsa045101.01692567
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99228075
46Viral myocarditis_Homo sapiens_hsa054160.98466746
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.98285478
48Renal cell carcinoma_Homo sapiens_hsa052110.98191708
49Long-term depression_Homo sapiens_hsa047300.97649308
50Choline metabolism in cancer_Homo sapiens_hsa052310.96978562
51Inositol phosphate metabolism_Homo sapiens_hsa005620.96804186
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96092618
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95989551
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95863885
55Calcium signaling pathway_Homo sapiens_hsa040200.95805463
56T cell receptor signaling pathway_Homo sapiens_hsa046600.95736626
57Prostate cancer_Homo sapiens_hsa052150.95176402
58Rap1 signaling pathway_Homo sapiens_hsa040150.94701385
59Circadian entrainment_Homo sapiens_hsa047130.94231889
60Proteoglycans in cancer_Homo sapiens_hsa052050.94122862
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93616995
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93101716
63Insulin signaling pathway_Homo sapiens_hsa049100.93000809
64Hepatitis C_Homo sapiens_hsa051600.92749240
65Influenza A_Homo sapiens_hsa051640.90180876
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88273344
67Cardiac muscle contraction_Homo sapiens_hsa042600.87641209
68Cholinergic synapse_Homo sapiens_hsa047250.87454684
69Leishmaniasis_Homo sapiens_hsa051400.86936869
70Axon guidance_Homo sapiens_hsa043600.86320109
71Adherens junction_Homo sapiens_hsa045200.86293348
72Platelet activation_Homo sapiens_hsa046110.86279116
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85247700
74Insulin secretion_Homo sapiens_hsa049110.84653341
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83746124
76Chemokine signaling pathway_Homo sapiens_hsa040620.83566932
77Thyroid cancer_Homo sapiens_hsa052160.82563891
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.82515622
79MAPK signaling pathway_Homo sapiens_hsa040100.82246167
80Serotonergic synapse_Homo sapiens_hsa047260.81810783
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81761571
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.81578413
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81004821
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80963552
85Amoebiasis_Homo sapiens_hsa051460.80864887
86Toxoplasmosis_Homo sapiens_hsa051450.80856537
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79201956
88Hematopoietic cell lineage_Homo sapiens_hsa046400.78804799
89Acute myeloid leukemia_Homo sapiens_hsa052210.78492695
90Apoptosis_Homo sapiens_hsa042100.78350337
91Ras signaling pathway_Homo sapiens_hsa040140.77764671
92Pertussis_Homo sapiens_hsa051330.77713137
93Morphine addiction_Homo sapiens_hsa050320.76883856
94ECM-receptor interaction_Homo sapiens_hsa045120.76856616
95Glioma_Homo sapiens_hsa052140.76633962
96Pancreatic cancer_Homo sapiens_hsa052120.76378043
97Non-small cell lung cancer_Homo sapiens_hsa052230.75634081
98Notch signaling pathway_Homo sapiens_hsa043300.75036622
99Staphylococcus aureus infection_Homo sapiens_hsa051500.74959723
100Estrogen signaling pathway_Homo sapiens_hsa049150.74926023
101Ovarian steroidogenesis_Homo sapiens_hsa049130.74397659
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73272192
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73085508
104Small cell lung cancer_Homo sapiens_hsa052220.72079660
105Taste transduction_Homo sapiens_hsa047420.70793537
106Tuberculosis_Homo sapiens_hsa051520.70216077
107Endocytosis_Homo sapiens_hsa041440.70038305
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69538606
109Dopaminergic synapse_Homo sapiens_hsa047280.68457150
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68315188
111AMPK signaling pathway_Homo sapiens_hsa041520.65845342
112Primary immunodeficiency_Homo sapiens_hsa053400.65695473
113Olfactory transduction_Homo sapiens_hsa047400.64619344
114HIF-1 signaling pathway_Homo sapiens_hsa040660.63874770
115Phagosome_Homo sapiens_hsa041450.63749175
116ErbB signaling pathway_Homo sapiens_hsa040120.62125882
117Shigellosis_Homo sapiens_hsa051310.61599511
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61508143
119Circadian rhythm_Homo sapiens_hsa047100.61306264
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.60367497
121Melanogenesis_Homo sapiens_hsa049160.59796713
122HTLV-I infection_Homo sapiens_hsa051660.59483484
123Pathways in cancer_Homo sapiens_hsa052000.59183008
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59004002
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57716927
126African trypanosomiasis_Homo sapiens_hsa051430.57665386
127Cocaine addiction_Homo sapiens_hsa050300.57307536
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.56776106
129Vitamin B6 metabolism_Homo sapiens_hsa007500.56696172
130Tight junction_Homo sapiens_hsa045300.56583929
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56051473
132Pancreatic secretion_Homo sapiens_hsa049720.55469013
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.54213967
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.54068089
135Amphetamine addiction_Homo sapiens_hsa050310.53819137
136Gap junction_Homo sapiens_hsa045400.53788476
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52024470

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