FOXK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.56897462
2mitotic chromosome condensation (GO:0007076)4.48340496
3proline biosynthetic process (GO:0006561)4.31799109
4locomotory exploration behavior (GO:0035641)4.20261907
5synaptic vesicle maturation (GO:0016188)4.06947971
6DNA unwinding involved in DNA replication (GO:0006268)4.05231017
7regulation of mammary gland epithelial cell proliferation (GO:0033599)3.92658552
8regulation of short-term neuronal synaptic plasticity (GO:0048172)3.91522627
9pre-miRNA processing (GO:0031054)3.71482186
10peptidyl-lysine dimethylation (GO:0018027)3.67570529
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65192495
12activation of Rac GTPase activity (GO:0032863)3.52525818
13COPI coating of Golgi vesicle (GO:0048205)3.49318689
14Golgi transport vesicle coating (GO:0048200)3.49318689
15establishment of nucleus localization (GO:0040023)3.42971223
16spliceosomal tri-snRNP complex assembly (GO:0000244)3.40103352
17positive regulation of DNA-dependent DNA replication (GO:2000105)3.39364579
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.36678315
19mitotic sister chromatid segregation (GO:0000070)3.33404403
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.33005715
21desmosome organization (GO:0002934)3.28491615
22pore complex assembly (GO:0046931)3.25106510
23dendritic spine morphogenesis (GO:0060997)3.21607544
24cytoplasmic mRNA processing body assembly (GO:0033962)3.20874348
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.19014863
26cell-substrate adherens junction assembly (GO:0007045)3.18922186
27focal adhesion assembly (GO:0048041)3.18922186
28dendrite morphogenesis (GO:0048813)3.16333795
29cell migration in hindbrain (GO:0021535)3.15602430
30protein complex localization (GO:0031503)3.12735000
31sister chromatid segregation (GO:0000819)3.11847723
32apoptotic process involved in morphogenesis (GO:0060561)3.11631039
33proline metabolic process (GO:0006560)3.10523378
34exploration behavior (GO:0035640)3.07131261
35cellular protein complex localization (GO:0034629)3.06538171
36NLS-bearing protein import into nucleus (GO:0006607)3.05767873
37glucocorticoid receptor signaling pathway (GO:0042921)3.05046183
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.04588669
39activation of protein kinase A activity (GO:0034199)3.03721273
40chromosome condensation (GO:0030261)3.02256679
41glutamate secretion (GO:0014047)2.98297166
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93620836
43positive regulation of synapse maturation (GO:0090129)2.90538419
44regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.89627149
45negative regulation of cell size (GO:0045792)2.89529249
46sodium ion export (GO:0071436)2.89252290
47regulation of RNA export from nucleus (GO:0046831)2.88720154
48vocalization behavior (GO:0071625)2.83923843
49DNA replication initiation (GO:0006270)2.83877330
50nucleosome disassembly (GO:0006337)2.83569647
51protein-DNA complex disassembly (GO:0032986)2.83569647
52regulation of translational termination (GO:0006449)2.82146940
53mitotic G1 DNA damage checkpoint (GO:0031571)2.80849859
54regulation of clathrin-mediated endocytosis (GO:2000369)2.80802067
55regulation of synaptic vesicle exocytosis (GO:2000300)2.80251063
56proline transport (GO:0015824)2.79996379
57ribosomal small subunit biogenesis (GO:0042274)2.79677206
58clathrin coat assembly (GO:0048268)2.79399026
59plasma membrane repair (GO:0001778)2.77608480
60positive regulation of fibroblast migration (GO:0010763)2.77193147
61heterochromatin organization (GO:0070828)2.75130073
62cell-substrate junction assembly (GO:0007044)2.74310475
63regulation of glutamate receptor signaling pathway (GO:1900449)2.74241546
64retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.74186249
65RNA localization (GO:0006403)2.73622204
66nerve growth factor signaling pathway (GO:0038180)2.72882015
67negative regulation of organelle assembly (GO:1902116)2.72750038
68nuclear pore complex assembly (GO:0051292)2.71701083
69regulation of synapse structural plasticity (GO:0051823)2.71436177
70regulation of NFAT protein import into nucleus (GO:0051532)2.70954724
71regulation of nucleobase-containing compound transport (GO:0032239)2.70477328
72hippo signaling (GO:0035329)2.70446824
73mitotic sister chromatid cohesion (GO:0007064)2.68039154
74hemidesmosome assembly (GO:0031581)2.67673269
75protein localization to microtubule (GO:0035372)2.67364544
76DNA strand renaturation (GO:0000733)2.66869738
77cerebellar Purkinje cell layer development (GO:0021680)2.66782711
78protein export from nucleus (GO:0006611)2.65403035
79negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64678383
80G1 DNA damage checkpoint (GO:0044783)2.64506925
81basement membrane organization (GO:0071711)2.64349836
82positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.63979423
83corticosteroid receptor signaling pathway (GO:0031958)2.63543632
84regulation of cholesterol homeostasis (GO:2000188)2.61346333
85embryonic eye morphogenesis (GO:0048048)2.61230537
86adherens junction assembly (GO:0034333)2.60714254
87mitotic nuclear envelope disassembly (GO:0007077)2.60438150
88neuromuscular process controlling balance (GO:0050885)2.60243285
89insulin-like growth factor receptor signaling pathway (GO:0048009)2.59634663
90stress fiber assembly (GO:0043149)2.59624409
91protein localization to endosome (GO:0036010)2.59396388
92maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59111796
93TOR signaling (GO:0031929)2.58932963
94synaptic vesicle exocytosis (GO:0016079)2.58121147
95regulation of translational fidelity (GO:0006450)2.57818471
96DNA duplex unwinding (GO:0032508)2.57693572
97regulation of hippo signaling (GO:0035330)2.57424555
98regulation of dendritic spine morphogenesis (GO:0061001)2.57154214
99peptidyl-arginine methylation (GO:0018216)2.56636463
100peptidyl-arginine N-methylation (GO:0035246)2.56636463
101peptidyl-threonine phosphorylation (GO:0018107)2.56340801
102regulation of fatty acid beta-oxidation (GO:0031998)2.56168970
103nuclear pore organization (GO:0006999)2.53946175
104nuclear envelope disassembly (GO:0051081)2.53625702
105membrane disassembly (GO:0030397)2.53625702
106protein retention in ER lumen (GO:0006621)2.53388121
107regulation of ARF protein signal transduction (GO:0032012)2.53382302
108glial cell proliferation (GO:0014009)2.53302292
109dendritic spine organization (GO:0097061)2.53055335
110peptidyl-arginine omega-N-methylation (GO:0035247)2.52174097
111axon extension (GO:0048675)2.51905624
112cell communication by electrical coupling (GO:0010644)2.51267227
113regulation of ARF GTPase activity (GO:0032312)2.50280541
114axonal fasciculation (GO:0007413)2.49923308
115peptidyl-threonine modification (GO:0018210)2.49770604
116negative regulation of microtubule polymerization (GO:0031115)2.49119831
117maternal placenta development (GO:0001893)2.48876821
118cellular response to epidermal growth factor stimulus (GO:0071364)2.48692534
119regulation of histone H3-K27 methylation (GO:0061085)2.48331539
120regulation of chromatin binding (GO:0035561)2.48175825
121positive regulation of protein export from nucleus (GO:0046827)2.47984908
122establishment of apical/basal cell polarity (GO:0035089)2.47801619
123chromatin assembly (GO:0031497)2.47499526
124DNA packaging (GO:0006323)2.46933291
125polarized epithelial cell differentiation (GO:0030859)2.46383330
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.44156096
127rRNA transcription (GO:0009303)2.43175551
128mitotic G1/S transition checkpoint (GO:0044819)2.42712361
129positive regulation of nuclease activity (GO:0032075)2.42090554
130vesicle transport along microtubule (GO:0047496)2.42048375
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.42004766
132snRNA metabolic process (GO:0016073)2.41982252
133negative regulation of fatty acid transport (GO:2000192)2.41067516
134cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.41042317
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.39735973
136cellular response to nerve growth factor stimulus (GO:1990090)2.39414490
137response to nerve growth factor (GO:1990089)2.39414490
138body morphogenesis (GO:0010171)2.38942491
139RNA stabilization (GO:0043489)2.38443385
140mRNA stabilization (GO:0048255)2.38443385
141branching involved in mammary gland duct morphogenesis (GO:0060444)2.37546705
142organelle transport along microtubule (GO:0072384)2.37536032
143semaphorin-plexin signaling pathway (GO:0071526)2.37190089
144G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.36424959
145DNA topological change (GO:0006265)2.35830684
146DNA strand elongation (GO:0022616)2.35782504
147DNA conformation change (GO:0071103)2.35694638
148DNA strand elongation involved in DNA replication (GO:0006271)2.35663324
149DNA geometric change (GO:0032392)2.35640895
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.35376842
151neural tube development (GO:0021915)2.35253418
152regulation of long-term neuronal synaptic plasticity (GO:0048169)2.34202524
153positive regulation of dendrite morphogenesis (GO:0050775)2.33970079
154protein localization to chromosome, centromeric region (GO:0071459)2.31573826
155regulation of neuronal synaptic plasticity (GO:0048168)2.31432902
156cell-cell junction maintenance (GO:0045217)2.30959607
157SMAD protein complex assembly (GO:0007183)2.29524368
158protein localization to synapse (GO:0035418)2.28098253
159stress granule assembly (GO:0034063)2.28063286
160regulation of mitotic spindle organization (GO:0060236)2.27968773
161regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.27566095
162neurotransmitter secretion (GO:0007269)2.26824477
163neuron recognition (GO:0008038)2.26654200
164mitochondrion transport along microtubule (GO:0047497)2.24893250
165establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.24893250
166neuron projection extension (GO:1990138)2.24802099
167positive regulation of axon extension (GO:0045773)2.24597115
168protein localization to kinetochore (GO:0034501)2.24198240
169regulation of early endosome to late endosome transport (GO:2000641)2.24166220
170intracellular estrogen receptor signaling pathway (GO:0030520)2.24148675
171negative regulation of catenin import into nucleus (GO:0035414)2.23614324
172ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.23523234
173negative regulation of histone methylation (GO:0031061)2.23336487
174monoubiquitinated protein deubiquitination (GO:0035520)2.23006673
175positive regulation of histone deacetylation (GO:0031065)2.22840489
176central nervous system projection neuron axonogenesis (GO:0021952)2.21394408

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.76849437
2EZH2_22144423_ChIP-Seq_EOC_Human3.21149823
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15906354
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.14282915
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.05142014
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.91868346
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.90320716
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.84884777
9TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.69462906
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.49624627
11* MYC_22102868_ChIP-Seq_BL_Human2.41201215
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.40259110
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36879952
14* KDM2B_26808549_Chip-Seq_DND41_Human2.36537965
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.33579440
16E2F7_22180533_ChIP-Seq_HELA_Human2.28459337
17ZFP281_27345836_Chip-Seq_ESCs_Mouse2.25869483
18DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.13889038
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11283299
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.10098165
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08495013
22* KDM2B_26808549_Chip-Seq_K562_Human2.06635513
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04220026
24VDR_21846776_ChIP-Seq_THP-1_Human2.03504571
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00450724
26AR_21909140_ChIP-Seq_LNCAP_Human1.98163008
27* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98130354
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97604913
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.92735923
30ZNF263_19887448_ChIP-Seq_K562_Human1.91275133
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89629656
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86774018
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.85970823
34DROSHA_22980978_ChIP-Seq_HELA_Human1.84266359
35TCF7_22412390_ChIP-Seq_EML_Mouse1.81227663
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77559726
37* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.75931543
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.72621738
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69440737
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63894853
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.61413198
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61233648
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58300235
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56917154
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56475626
46XRN2_22483619_ChIP-Seq_HELA_Human1.56108411
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54898544
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53271059
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53154866
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51929420
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49500385
52CLOCK_20551151_ChIP-Seq_293T_Human1.45814893
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.45142415
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44687478
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43276459
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42566100
57* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41790892
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39674610
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39396352
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38439944
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38005464
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37634774
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37634774
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36986788
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35211176
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33773789
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33278545
68PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32864865
69REST_21632747_ChIP-Seq_MESCs_Mouse1.32862366
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32449011
71KDM5A_27292631_Chip-Seq_BREAST_Human1.31845979
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31280764
73CREB1_26743006_Chip-Seq_LNCaP_Human1.30811060
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30309860
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.28609910
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28327867
77ZNF274_21170338_ChIP-Seq_K562_Hela1.27399928
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27390230
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.25950685
80P68_20966046_ChIP-Seq_HELA_Human1.25858814
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.24848203
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24138924
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23854939
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22743802
85SMC4_20622854_ChIP-Seq_HELA_Human1.22186440
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21833222
87* ISL1_27105846_Chip-Seq_CPCs_Mouse1.21200320
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.20950021
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20562122
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19870711
91* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18478752
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18149309
93* LXR_22292898_ChIP-Seq_THP-1_Human1.17934016
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17320567
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16878131
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16822351
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.15448365
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.15224944
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15119316
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15049015
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.14835849
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13748305
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12946806
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12166289
105* AR_19668381_ChIP-Seq_PC3_Human1.11691670
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11400967
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10625594
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09714312
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09073204
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09071175
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09019125
112* NCOR1_26117541_ChIP-Seq_K562_Human1.06848194
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.06830403
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06596883
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06164167
116CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05779953
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.05735133
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04849649
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04348059
120RACK7_27058665_Chip-Seq_MCF-7_Human1.03878302
121NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03069318
122TP53_16413492_ChIP-PET_HCT116_Human1.02639897
123JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01966531
124* ATF3_27146783_Chip-Seq_COLON_Human1.01764332
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01729525
126* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01499145
127EZH2_27304074_Chip-Seq_ESCs_Mouse1.00812947
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00556458
129ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00105917
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99381357
131NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99054506
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.98476170
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98293005
134TP53_22127205_ChIP-Seq_IMR90_Human0.98110093
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.97690541
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96902181
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96564826
138* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95517461
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95366765
140TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94623551
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.94589091
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94513310
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.94505281
144AR_21572438_ChIP-Seq_LNCaP_Human0.93230272
145* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92979419
146ESR1_21235772_ChIP-Seq_MCF-7_Human0.92740063
147* SOX2_21211035_ChIP-Seq_LN229_Gbm0.92547649
148TET1_21490601_ChIP-Seq_MESCs_Mouse0.91426277
149* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90617445
150* CHD1_26751641_Chip-Seq_LNCaP_Human0.90513013
151ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90469277
152SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90056641
153SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89895485
154FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88359652
155SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88047053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.41028249
2MP0003705_abnormal_hypodermis_morpholog3.32867870
3MP0005623_abnormal_meninges_morphology2.71745612
4MP0005076_abnormal_cell_differentiation2.52262482
5MP0004233_abnormal_muscle_weight2.46095375
6MP0010352_gastrointestinal_tract_polyps2.42253686
7MP0000569_abnormal_digit_pigmentation2.38173421
8MP0005409_darkened_coat_color2.29946417
9MP0003635_abnormal_synaptic_transmissio2.29725799
10MP0005451_abnormal_body_composition2.24573971
11MP0004270_analgesia2.23747046
12MP0009780_abnormal_chondrocyte_physiolo2.22162106
13MP0003693_abnormal_embryo_hatching2.19783842
14MP0000537_abnormal_urethra_morphology2.15500389
15MP0004858_abnormal_nervous_system2.14034062
16MP0010234_abnormal_vibrissa_follicle2.11514777
17MP0002877_abnormal_melanocyte_morpholog1.97731724
18MP0000678_abnormal_parathyroid_gland1.97007734
19MP0003123_paternal_imprinting1.95823101
20MP0000566_synostosis1.93511713
21MP0002063_abnormal_learning/memory/cond1.81655179
22MP0002249_abnormal_larynx_morphology1.79895682
23MP0010094_abnormal_chromosome_stability1.77897422
24MP0004957_abnormal_blastocyst_morpholog1.75835633
25MP0005187_abnormal_penis_morphology1.74367205
26MP0003077_abnormal_cell_cycle1.71529129
27MP0001348_abnormal_lacrimal_gland1.62838690
28MP0000778_abnormal_nervous_system1.62182707
29MP0004811_abnormal_neuron_physiology1.54818692
30MP0000733_abnormal_muscle_development1.52032642
31MP0003315_abnormal_perineum_morphology1.49300966
32MP0008961_abnormal_basal_metabolism1.47827794
33MP0002796_impaired_skin_barrier1.44641742
34MP0002084_abnormal_developmental_patter1.44557954
35MP0003861_abnormal_nervous_system1.38618571
36MP0003283_abnormal_digestive_organ1.38559638
37MP0001299_abnormal_eye_distance/1.38489302
38MP0002653_abnormal_ependyma_morphology1.38459876
39MP0003329_amyloid_beta_deposits1.38393041
40MP0003453_abnormal_keratinocyte_physiol1.38115627
41MP0008057_abnormal_DNA_replication1.37022479
42MP0000762_abnormal_tongue_morphology1.36348911
43MP0004197_abnormal_fetal_growth/weight/1.35846141
44MP0010030_abnormal_orbit_morphology1.35449060
45MP0003300_gastrointestinal_ulcer1.33590635
46MP0003303_peritoneal_inflammation1.33396626
47MP0001730_embryonic_growth_arrest1.33215148
48MP0003787_abnormal_imprinting1.33188727
49MP0008932_abnormal_embryonic_tissue1.33166677
50MP0001849_ear_inflammation1.30873515
51MP0001661_extended_life_span1.30377381
52MP0001346_abnormal_lacrimal_gland1.30331890
53MP0005501_abnormal_skin_physiology1.30153714
54MP0000579_abnormal_nail_morphology1.30142663
55MP0003121_genomic_imprinting1.28799177
56MP0003119_abnormal_digestive_system1.26502709
57MP0009053_abnormal_anal_canal1.26138078
58MP0009745_abnormal_behavioral_response1.22368576
59MP0000955_abnormal_spinal_cord1.22317290
60MP0003890_abnormal_embryonic-extraembry1.22286133
61MP0003385_abnormal_body_wall1.21883297
62MP0000428_abnormal_craniofacial_morphol1.21501778
63MP0004185_abnormal_adipocyte_glucose1.21380212
64MP0005423_abnormal_somatic_nervous1.21132380
65MP0000534_abnormal_ureter_morphology1.20917125
66MP0002152_abnormal_brain_morphology1.20824942
67MP0003091_abnormal_cell_migration1.20694251
68MP0002909_abnormal_adrenal_gland1.20265959
69MP0003115_abnormal_respiratory_system1.19306998
70MP0002098_abnormal_vibrissa_morphology1.18555232
71MP0002697_abnormal_eye_size1.17950523
72MP0004885_abnormal_endolymph1.17930433
73MP0004264_abnormal_extraembryonic_tissu1.17111290
74MP0002085_abnormal_embryonic_tissue1.16541793
75MP0003122_maternal_imprinting1.15198411
76MP0004381_abnormal_hair_follicle1.14034262
77MP0002734_abnormal_mechanical_nocicepti1.13576799
78MP0004272_abnormal_basement_membrane1.12411612
79MP0002184_abnormal_innervation1.12229258
80MP0009672_abnormal_birth_weight1.12115990
81MP0002064_seizures1.08734320
82MP0010630_abnormal_cardiac_muscle1.07821889
83MP0000003_abnormal_adipose_tissue1.07266037
84MP0000759_abnormal_skeletal_muscle1.07130910
85MP0005248_abnormal_Harderian_gland1.06988230
86MP0002572_abnormal_emotion/affect_behav1.06958838
87MP0001697_abnormal_embryo_size1.06816743
88MP0008770_decreased_survivor_rate1.06359218
89MP0005380_embryogenesis_phenotype1.06337390
90MP0001672_abnormal_embryogenesis/_devel1.06337390
91MP0002092_abnormal_eye_morphology1.05516506
92MP0003984_embryonic_growth_retardation1.05205105
93MP0009703_decreased_birth_body1.04335546
94MP0002088_abnormal_embryonic_growth/wei1.03844093
95MP0002234_abnormal_pharynx_morphology1.03686951
96MP0010307_abnormal_tumor_latency1.02910059
97MP0002089_abnormal_postnatal_growth/wei1.02007394
98MP0005375_adipose_tissue_phenotype1.00559426
99MP0002086_abnormal_extraembryonic_tissu1.00381360
100MP0005058_abnormal_lysosome_morphology1.00079401
101MP0000350_abnormal_cell_proliferation0.99690816
102MP0005257_abnormal_intraocular_pressure0.98789049
103MP0005666_abnormal_adipose_tissue0.98482562
104MP0003935_abnormal_craniofacial_develop0.98048005
105MP0002060_abnormal_skin_morphology0.97763435
106MP0003111_abnormal_nucleus_morphology0.97649137
107MP0003942_abnormal_urinary_system0.97049756
108MP0002396_abnormal_hematopoietic_system0.96751478
109MP0000747_muscle_weakness0.95725270
110MP0002269_muscular_atrophy0.95462943
111MP0004087_abnormal_muscle_fiber0.93323730
112MP0009046_muscle_twitch0.92311504
113MP0001340_abnormal_eyelid_morphology0.91365917
114MP0000751_myopathy0.91049765
115MP0002733_abnormal_thermal_nociception0.88346227
116MP0002160_abnormal_reproductive_system0.88244883
117MP0002882_abnormal_neuron_morphology0.87846276
118MP0002925_abnormal_cardiovascular_devel0.87500745
119MP0002081_perinatal_lethality0.87440471
120MP0001270_distended_abdomen0.86637492
121MP0000432_abnormal_head_morphology0.86215106
122MP0002080_prenatal_lethality0.85851785
123MP0000377_abnormal_hair_follicle0.85823743
124MP0002114_abnormal_axial_skeleton0.85645821
125MP0003937_abnormal_limbs/digits/tail_de0.84518387
126MP0008877_abnormal_DNA_methylation0.84484953
127MP0003755_abnormal_palate_morphology0.84360354
128MP0002557_abnormal_social/conspecific_i0.83804900
129MP0006138_congestive_heart_failure0.83571248
130MP0008569_lethality_at_weaning0.83559453
131MP0000467_abnormal_esophagus_morphology0.81941836
132MP0005386_behavior/neurological_phenoty0.80327253
133MP0004924_abnormal_behavior0.80327253
134MP0002116_abnormal_craniofacial_bone0.78579767
135MP0001216_abnormal_epidermal_layer0.78514814
136MP0009250_abnormal_appendicular_skeleto0.78404507
137MP0004782_abnormal_surfactant_physiolog0.78244596
138MP0004130_abnormal_muscle_cell0.78154782
139MP0002111_abnormal_tail_morphology0.78020659
140MP0002896_abnormal_bone_mineralization0.77893805
141MP0005621_abnormal_cell_physiology0.77663038
142MP0001915_intracranial_hemorrhage0.76415351
143MP0001440_abnormal_grooming_behavior0.74914229
144MP0001286_abnormal_eye_development0.74301610
145MP0001486_abnormal_startle_reflex0.74143234
146MP0003566_abnormal_cell_adhesion0.73707428
147MP0001968_abnormal_touch/_nociception0.73156463
148MP0009840_abnormal_foam_cell0.72381320
149MP0003880_abnormal_central_pattern0.72109511
150MP0003567_abnormal_fetal_cardiomyocyte0.72097620
151MP0005408_hypopigmentation0.71847872

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.08975617
2Termporal pattern (HP:0011008)3.01812708
3Insidious onset (HP:0003587)3.01812708
4Ulnar bowing (HP:0003031)3.00555642
5Shallow orbits (HP:0000586)2.96385383
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.84970343
7Short 4th metacarpal (HP:0010044)2.84970343
8Septate vagina (HP:0001153)2.79068878
9Insomnia (HP:0100785)2.68622240
10Macroorchidism (HP:0000053)2.68607256
11Abnormality of the lower motor neuron (HP:0002366)2.67617160
12Ankyloglossia (HP:0010296)2.65809832
13Renal duplication (HP:0000075)2.63617554
14Subacute progressive viral hepatitis (HP:0006572)2.61592088
15Papilledema (HP:0001085)2.61435014
16Flat acetabular roof (HP:0003180)2.59455084
17Pointed chin (HP:0000307)2.59309299
18Trismus (HP:0000211)2.53926539
19Abnormality of the fingertips (HP:0001211)2.41710642
20Enlarged penis (HP:0000040)2.38851997
21Astrocytoma (HP:0009592)2.38632157
22Abnormality of the astrocytes (HP:0100707)2.38632157
23Amyotrophic lateral sclerosis (HP:0007354)2.38211436
24Visual hallucinations (HP:0002367)2.35632703
25Disproportionate tall stature (HP:0001519)2.34652031
26Elfin facies (HP:0004428)2.33895870
27Urethral obstruction (HP:0000796)2.33054401
28Abnormality of oral frenula (HP:0000190)2.32778051
29Dysmetric saccades (HP:0000641)2.31343935
30Deviation of the thumb (HP:0009603)2.28444210
31Cerebral aneurysm (HP:0004944)2.26194261
32Abnormality of the 4th metacarpal (HP:0010012)2.24420979
33Buphthalmos (HP:0000557)2.24129381
34Overriding aorta (HP:0002623)2.23961054
35Renovascular hypertension (HP:0100817)2.23161273
36Bowel diverticulosis (HP:0005222)2.22094743
37Genu recurvatum (HP:0002816)2.20398142
38Urinary bladder sphincter dysfunction (HP:0002839)2.16816832
39Genetic anticipation (HP:0003743)2.16260745
40Broad face (HP:0000283)2.15125339
41Long palpebral fissure (HP:0000637)2.14947764
42Proximal placement of thumb (HP:0009623)2.14485297
43Distal upper limb amyotrophy (HP:0007149)2.14256214
44Upper limb amyotrophy (HP:0009129)2.14256214
45Impaired vibration sensation in the lower limbs (HP:0002166)2.13602125
46Patellar dislocation (HP:0002999)2.13130916
47Advanced eruption of teeth (HP:0006288)2.13062075
48Abnormality of the phalanges of the hallux (HP:0010057)2.12128100
49Deep venous thrombosis (HP:0002625)2.11891292
50Heterotopia (HP:0002282)2.11439742
51Sacral dimple (HP:0000960)2.09740418
52Urinary urgency (HP:0000012)2.08519816
53Overlapping toe (HP:0001845)2.08390963
54Abnormality of the distal phalanx of the thumb (HP:0009617)2.06903661
55Megalencephaly (HP:0001355)2.05808988
56Increased nuchal translucency (HP:0010880)2.05391947
57Apathy (HP:0000741)2.05076321
58Myokymia (HP:0002411)2.04419734
59Sparse lateral eyebrow (HP:0005338)2.04123547
60Cerebral inclusion bodies (HP:0100314)2.03203007
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01185168
62Obstructive sleep apnea (HP:0002870)1.99194273
63Hand muscle atrophy (HP:0009130)1.98759056
64Focal seizures (HP:0007359)1.97362859
65Achilles tendon contracture (HP:0001771)1.95436013
66Deviation of the hallux (HP:0010051)1.94427899
67Lower limb amyotrophy (HP:0007210)1.93764854
68Inappropriate behavior (HP:0000719)1.93062727
69Self-mutilation (HP:0000742)1.92802799
70Hallux valgus (HP:0001822)1.92442641
71Protrusio acetabuli (HP:0003179)1.92259365
72Increased density of long bones (HP:0006392)1.90283034
73Mitral valve prolapse (HP:0001634)1.89971376
74Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88939274
75Anal stenosis (HP:0002025)1.88231406
76Abnormality of the corticospinal tract (HP:0002492)1.88199543
77Impaired smooth pursuit (HP:0007772)1.88177782
78Fibroma (HP:0010614)1.88136058
79Intellectual disability, profound (HP:0002187)1.87487436
80Bladder diverticulum (HP:0000015)1.87418799
81Germ cell neoplasia (HP:0100728)1.87048491
82Aqueductal stenosis (HP:0002410)1.86271055
83High anterior hairline (HP:0009890)1.85862472
84Fibrous tissue neoplasm (HP:0012316)1.85628528
85Natal tooth (HP:0000695)1.84914390
86Lymphangioma (HP:0100764)1.82668212
87Long eyelashes (HP:0000527)1.81347299
88Abnormality of carpal bone ossification (HP:0006257)1.81322713
89Dislocated radial head (HP:0003083)1.80754982
90Resting tremor (HP:0002322)1.80696377
91Annular pancreas (HP:0001734)1.80055400
92Elbow flexion contracture (HP:0002987)1.79925996
93Ependymoma (HP:0002888)1.78846826
94Absent epiphyses (HP:0010577)1.78407163
95Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78407163
96Flat cornea (HP:0007720)1.77852054
97Abnormality of the thoracic spine (HP:0100711)1.77525700
98Lower limb asymmetry (HP:0100559)1.76681836
99Diminished motivation (HP:0000745)1.76314566
100Chromsome breakage (HP:0040012)1.75428860
101Abnormality of the radial head (HP:0003995)1.75295582
102Asymmetry of the thorax (HP:0001555)1.74811771
103Obsessive-compulsive behavior (HP:0000722)1.74361367
104Disinhibition (HP:0000734)1.74063950
105Bowel incontinence (HP:0002607)1.73848413
106Action tremor (HP:0002345)1.73689392
107Shoulder girdle muscle weakness (HP:0003547)1.72914774
108Lip pit (HP:0100267)1.72127306
109Limited elbow extension (HP:0001377)1.71789839
110Poor eye contact (HP:0000817)1.71601099
111Abnormal ossification of hand bones (HP:0005921)1.71367846
112Progressive muscle weakness (HP:0003323)1.70959847
113Megalocornea (HP:0000485)1.70423341
114Atresia of the external auditory canal (HP:0000413)1.70257834
115Hyperparathyroidism (HP:0000843)1.69927266
116Hyperthyroidism (HP:0000836)1.69817645
117Pelvic girdle muscle weakness (HP:0003749)1.69662943
118High pitched voice (HP:0001620)1.69658017
119Broad thumb (HP:0011304)1.69035879
120Trigonocephaly (HP:0000243)1.68910407
121Abnormality of the distal phalanges of the toes (HP:0010182)1.67211133
122Supranuclear gaze palsy (HP:0000605)1.67115404
123Preauricular skin tag (HP:0000384)1.66251929
124Volvulus (HP:0002580)1.66206830
125Facial hemangioma (HP:0000329)1.66183046
126Distal lower limb amyotrophy (HP:0008944)1.66091515
127Cutaneous melanoma (HP:0012056)1.66071113
128Abnormal social behavior (HP:0012433)1.65254324
129Impaired social interactions (HP:0000735)1.65254324
130Nasolacrimal duct obstruction (HP:0000579)1.64101501
131Bowing of the arm (HP:0006488)1.63953403
132Bowed forearm bones (HP:0003956)1.63953403
133Abnormality of the Achilles tendon (HP:0005109)1.63819576
134Capillary hemangiomas (HP:0005306)1.62848218
135Rectal prolapse (HP:0002035)1.62638884
136Abnormality of ocular smooth pursuit (HP:0000617)1.61858030
137Abnormality of the aortic arch (HP:0012303)1.61787428
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.61071430
139Vertebral arch anomaly (HP:0008438)1.60385058
140Hypopigmentation of the fundus (HP:0007894)1.59878238
141Deep palmar crease (HP:0006191)1.59791958
142Depression (HP:0000716)1.59407984
143Abnormal large intestine physiology (HP:0012700)1.59297328
144Deep philtrum (HP:0002002)1.58802090
145Turricephaly (HP:0000262)1.58759100
146Hamartoma of the eye (HP:0010568)1.58715945
147Premature rupture of membranes (HP:0001788)1.58651205
148Excessive salivation (HP:0003781)1.58611477
149Drooling (HP:0002307)1.58611477
150Exostoses (HP:0100777)1.58306867
151Overgrowth (HP:0001548)1.58220154
152Dilatation of the ascending aorta (HP:0005111)1.58187292
153Truncus arteriosus (HP:0001660)1.58002067
154Ankle clonus (HP:0011448)1.57996678
155Skull defect (HP:0001362)1.57696203
156Neoplasm of the heart (HP:0100544)1.57657990
157Abnormality of the diencephalon (HP:0010662)1.57333196
158Absent frontal sinuses (HP:0002688)1.57265357
159Abnormality of the lacrimal duct (HP:0011481)1.57235563
160Transitional cell carcinoma of the bladder (HP:0006740)1.57180668
161Right ventricular cardiomyopathy (HP:0011663)1.56786423
162Papillary thyroid carcinoma (HP:0002895)1.56721574
163Pterygium (HP:0001059)1.56544544
164Thin ribs (HP:0000883)1.56296225
165Selective tooth agenesis (HP:0001592)1.55967804
166Congenital glaucoma (HP:0001087)1.55341848
167Premature skin wrinkling (HP:0100678)1.54648145
168Midface retrusion (HP:0011800)1.54093576
169Abnormal ventriculo-arterial connection (HP:0011563)1.53747193
170Transposition of the great arteries (HP:0001669)1.53747193
171Abnormal connection of the cardiac segments (HP:0011545)1.53747193
172Abnormality of the calcaneus (HP:0008364)1.53591040
173Squamous cell carcinoma (HP:0002860)1.51776425
174Oligodontia (HP:0000677)1.50786997
175Abnormality of the salivary glands (HP:0010286)1.50557502
176Spinal cord compression (HP:0002176)1.50248380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.38607353
2SMG13.21595298
3MARK13.01283795
4PKN22.95617768
5EEF2K2.88855453
6MAP3K92.75280068
7LATS22.68825526
8PRKD32.48990329
9PAK62.24745033
10IRAK32.23753359
11NTRK32.06933481
12LATS12.06458560
13KSR22.06445465
14SCYL21.90257652
15EPHA21.85247198
16ALK1.80892523
17CDK121.78376268
18PRPF4B1.77651487
19TAOK11.75597250
20TYRO31.73614154
21ICK1.72492857
22MST1R1.72193116
23RIPK11.68727933
24KSR11.66274508
25MAP3K41.64408060
26ERN11.63610280
27PDGFRA1.62670553
28MINK11.57551067
29MAP3K101.57136398
30FGFR41.55158747
31CAMKK11.49225995
32CDC71.47402272
33TTN1.42697091
34NME21.39941871
35DMPK1.39678131
36CDK71.39010392
37NTRK21.38822882
38NEK11.38759341
39RET1.37824522
40EPHA41.30396598
41DAPK21.29410530
42DDR21.28512652
43BMX1.26525372
44CAMK1G1.23987816
45ARAF1.19523415
46NTRK11.18704025
47TTK1.17889503
48RPS6KB21.15922998
49SIK21.15193691
50MAP3K21.12080155
51MET1.06735708
52PTK61.05442164
53PAK21.04105334
54NEK21.02540088
55SIK31.01291062
56BRD41.00943960
57CDK80.98735928
58BRAF0.96567391
59* MTOR0.96461269
60PLK20.93160393
61PHKG20.91851934
62PHKG10.91851934
63STK380.90043654
64MARK20.89114155
65PDGFRB0.85008696
66PNCK0.84427654
67STK110.83042359
68MAPK110.80961203
69CDK150.80683275
70MAP3K130.80428905
71PAK30.79644186
72CDK50.79144021
73CDK140.79109914
74PRKCH0.78398295
75CDK180.74892025
76FGFR10.74505950
77EIF2AK10.74030176
78FGFR20.72952389
79MAP2K40.72043213
80PTK20.71227893
81AKT20.69475348
82CDK11A0.68255259
83CAMK1D0.68117908
84FGFR30.67759449
85MAP3K60.67224820
86WEE10.66840742
87BUB10.64635683
88BRSK10.64625693
89AURKA0.63551001
90MAP3K30.63525456
91TESK10.61977908
92PDPK10.61344625
93MOS0.60864569
94UHMK10.57461497
95RAF10.57441873
96IRAK20.56322038
97MAP3K10.55254569
98MAP3K70.54944669
99CDK60.54862924
100DAPK10.54261085
101CSNK1D0.53715268
102PDK30.53522772
103PDK40.53522772
104PRKD20.53251522
105PAK40.53080569
106CDC42BPA0.52408654
107MAP3K80.52127481
108RPS6KA20.52119668
109MAPKAPK30.51975793
110ILK0.51806599
111CSNK1G20.51496800
112PRKCI0.49424306
113CHEK10.48166001
114ATR0.47752204
115RPS6KB10.47418577
116STK30.47418489
117PTK2B0.45052263
118CDK40.45042142
119* CDK20.44937342
120CSNK1E0.44720359
121LRRK20.44359248
122MELK0.43773773
123MAPK100.43514733
124PRKAA10.42556692
125RPS6KA30.42539946
126CDK90.41871797
127EPHB20.40782100
128SGK30.39468544
129MAP2K20.38729523
130AURKB0.38568094
131CHEK20.38122915
132PDK10.37928528
133PLK30.37507280
134MAPK80.37223451
135TSSK60.36732084
136MAP2K30.36573761
137TAOK20.36533946
138GSK3B0.36328077
139ATM0.36140183
140SIK10.36120614
141PRKDC0.35826216
142WNK10.35249215
143* CDK10.34799700
144RPS6KA10.34296004
145PLK10.33032535

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.22189957
2Long-term potentiation_Homo sapiens_hsa047201.96511142
3Glioma_Homo sapiens_hsa052141.81745950
4Lysine degradation_Homo sapiens_hsa003101.81502328
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79472279
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75545235
7DNA replication_Homo sapiens_hsa030301.75026919
8mTOR signaling pathway_Homo sapiens_hsa041501.66468336
9Estrogen signaling pathway_Homo sapiens_hsa049151.63893778
10Cell cycle_Homo sapiens_hsa041101.63817045
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52348291
12Endometrial cancer_Homo sapiens_hsa052131.48614960
13Dopaminergic synapse_Homo sapiens_hsa047281.47659877
14Circadian entrainment_Homo sapiens_hsa047131.45640591
15Chronic myeloid leukemia_Homo sapiens_hsa052201.43561899
16Olfactory transduction_Homo sapiens_hsa047401.41422878
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41114717
18Notch signaling pathway_Homo sapiens_hsa043301.40900490
19Amphetamine addiction_Homo sapiens_hsa050311.40808117
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.40101103
21Colorectal cancer_Homo sapiens_hsa052101.38897890
22Dorso-ventral axis formation_Homo sapiens_hsa043201.38638603
23Oocyte meiosis_Homo sapiens_hsa041141.35949158
24Renal cell carcinoma_Homo sapiens_hsa052111.35215098
25Cholinergic synapse_Homo sapiens_hsa047251.34004108
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.32629976
27Acute myeloid leukemia_Homo sapiens_hsa052211.32471729
28Non-small cell lung cancer_Homo sapiens_hsa052231.31652922
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30564588
30Oxytocin signaling pathway_Homo sapiens_hsa049211.30259200
31Glutamatergic synapse_Homo sapiens_hsa047241.29940853
32Gap junction_Homo sapiens_hsa045401.29781670
33Synaptic vesicle cycle_Homo sapiens_hsa047211.27117403
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26417462
35GnRH signaling pathway_Homo sapiens_hsa049121.26230013
36Type II diabetes mellitus_Homo sapiens_hsa049301.25963077
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25711288
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.24485065
39ErbB signaling pathway_Homo sapiens_hsa040121.24103199
40Axon guidance_Homo sapiens_hsa043601.24045835
41VEGF signaling pathway_Homo sapiens_hsa043701.22382745
42Melanogenesis_Homo sapiens_hsa049161.20609975
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20427901
44Gastric acid secretion_Homo sapiens_hsa049711.20257486
45RNA transport_Homo sapiens_hsa030131.18678971
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17879235
47Hippo signaling pathway_Homo sapiens_hsa043901.17050286
48Insulin secretion_Homo sapiens_hsa049111.16903816
49Sulfur relay system_Homo sapiens_hsa041221.16014842
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15500827
51Biosynthesis of amino acids_Homo sapiens_hsa012301.14976685
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14725514
53GABAergic synapse_Homo sapiens_hsa047271.13242363
54Salivary secretion_Homo sapiens_hsa049701.12478165
55Adherens junction_Homo sapiens_hsa045201.11290217
56Long-term depression_Homo sapiens_hsa047301.11276030
57MicroRNAs in cancer_Homo sapiens_hsa052061.11111875
58Pancreatic cancer_Homo sapiens_hsa052121.10365583
59Cocaine addiction_Homo sapiens_hsa050301.08724913
60Morphine addiction_Homo sapiens_hsa050321.08342710
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08291166
62Proteoglycans in cancer_Homo sapiens_hsa052051.08103939
63Renin secretion_Homo sapiens_hsa049241.06941927
64Prion diseases_Homo sapiens_hsa050201.05652226
65N-Glycan biosynthesis_Homo sapiens_hsa005101.04613189
66Dilated cardiomyopathy_Homo sapiens_hsa054141.04395044
67Nicotine addiction_Homo sapiens_hsa050331.04192994
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04166117
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03235462
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03228654
71Focal adhesion_Homo sapiens_hsa045101.03207665
72Inositol phosphate metabolism_Homo sapiens_hsa005621.01691745
73Glucagon signaling pathway_Homo sapiens_hsa049221.01406526
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99531739
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98714044
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98096207
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.96459098
78Pentose phosphate pathway_Homo sapiens_hsa000300.94399107
79Bladder cancer_Homo sapiens_hsa052190.94242828
80Insulin signaling pathway_Homo sapiens_hsa049100.93984663
81Spliceosome_Homo sapiens_hsa030400.92947117
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91233403
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90904219
84mRNA surveillance pathway_Homo sapiens_hsa030150.90787775
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88312431
86Wnt signaling pathway_Homo sapiens_hsa043100.87163531
87MAPK signaling pathway_Homo sapiens_hsa040100.87139699
88Viral myocarditis_Homo sapiens_hsa054160.86984776
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86292964
90Base excision repair_Homo sapiens_hsa034100.86272010
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85804702
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85550358
93cAMP signaling pathway_Homo sapiens_hsa040240.84513715
94Rap1 signaling pathway_Homo sapiens_hsa040150.83814833
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83619808
96Tight junction_Homo sapiens_hsa045300.83435193
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81788497
98Fatty acid biosynthesis_Homo sapiens_hsa000610.81590806
99Choline metabolism in cancer_Homo sapiens_hsa052310.81191471
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81035905
101Thyroid cancer_Homo sapiens_hsa052160.80602199
102Alcoholism_Homo sapiens_hsa050340.80413005
103AMPK signaling pathway_Homo sapiens_hsa041520.79319487
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78736386
105Nucleotide excision repair_Homo sapiens_hsa034200.78702855
106ECM-receptor interaction_Homo sapiens_hsa045120.78426901
107Basal cell carcinoma_Homo sapiens_hsa052170.78419701
108Prolactin signaling pathway_Homo sapiens_hsa049170.77545849
109One carbon pool by folate_Homo sapiens_hsa006700.77240086
110Nitrogen metabolism_Homo sapiens_hsa009100.77176771
111Fructose and mannose metabolism_Homo sapiens_hsa000510.76061489
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75350892
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74846240
114Small cell lung cancer_Homo sapiens_hsa052220.74431698
115Hedgehog signaling pathway_Homo sapiens_hsa043400.74419082
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73709388
117Thyroid hormone synthesis_Homo sapiens_hsa049180.72469698
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71141613
119Endocytosis_Homo sapiens_hsa041440.70882569
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69076649
121Melanoma_Homo sapiens_hsa052180.67613683
122FoxO signaling pathway_Homo sapiens_hsa040680.67293099
123Prostate cancer_Homo sapiens_hsa052150.67194345
124Platelet activation_Homo sapiens_hsa046110.64601034
125Steroid biosynthesis_Homo sapiens_hsa001000.64170769
126Other glycan degradation_Homo sapiens_hsa005110.63724664
127Insulin resistance_Homo sapiens_hsa049310.63448841
128HTLV-I infection_Homo sapiens_hsa051660.61925203
129HIF-1 signaling pathway_Homo sapiens_hsa040660.61657658
130TGF-beta signaling pathway_Homo sapiens_hsa043500.61398269
131Pathways in cancer_Homo sapiens_hsa052000.61381496
132p53 signaling pathway_Homo sapiens_hsa041150.60257141
133Viral carcinogenesis_Homo sapiens_hsa052030.59163018
134Hepatitis B_Homo sapiens_hsa051610.59141237
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.58072666
136Arginine biosynthesis_Homo sapiens_hsa002200.56129900
137Arginine and proline metabolism_Homo sapiens_hsa003300.53993202
138Galactose metabolism_Homo sapiens_hsa000520.52312833
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51834176
140Vibrio cholerae infection_Homo sapiens_hsa051100.51617188

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