FOXL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors are characterized by a distinct DNA-binding forkhead domain and play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular visceral epithelial cell development (GO:0072015)5.93056773
2chondrocyte proliferation (GO:0035988)5.83957402
3exocrine pancreas development (GO:0031017)5.38052813
4glomerular basement membrane development (GO:0032836)5.37887289
5glomerular epithelial cell development (GO:0072310)5.22761080
6mesodermal cell differentiation (GO:0048333)5.08514456
7skin morphogenesis (GO:0043589)4.91716560
8protein heterotrimerization (GO:0070208)4.90059512
9endodermal cell differentiation (GO:0035987)4.85245255
10cell adhesion mediated by integrin (GO:0033627)4.51784031
11myoblast migration (GO:0051451)4.43535714
12collagen fibril organization (GO:0030199)4.38855521
13mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.28994655
14cell migration involved in heart development (GO:0060973)4.18125664
15axon extension involved in axon guidance (GO:0048846)4.17428639
16neuron projection extension involved in neuron projection guidance (GO:1902284)4.17428639
17glomerulus development (GO:0032835)4.10533428
18basement membrane organization (GO:0071711)4.07322598
19facial nerve structural organization (GO:0021612)4.05013644
20cell-substrate junction assembly (GO:0007044)4.03304241
21epithelial cell fate commitment (GO:0072148)4.01299962
22wound healing, spreading of epidermal cells (GO:0035313)3.98826496
23bone trabecula formation (GO:0060346)3.95502651
24endocardial cushion development (GO:0003197)3.88605177
25regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.87264673
26barbed-end actin filament capping (GO:0051016)3.86971315
27cellular response to vitamin (GO:0071295)3.86834420
28somite development (GO:0061053)3.84680480
29hemidesmosome assembly (GO:0031581)3.84606701
30substrate-dependent cell migration (GO:0006929)3.84404199
31signal peptide processing (GO:0006465)3.78049410
32endocardial cushion morphogenesis (GO:0003203)3.77037338
33extracellular matrix assembly (GO:0085029)3.68709708
34mesenchymal cell differentiation involved in kidney development (GO:0072161)3.68406813
35mesenchymal cell differentiation involved in renal system development (GO:2001012)3.68406813
36epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.67940374
37positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.64154409
38glycosphingolipid catabolic process (GO:0046479)3.62541433
39negative regulation of axon extension involved in axon guidance (GO:0048843)3.62357250
40positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.61222081
41type B pancreatic cell proliferation (GO:0044342)3.58876680
42negative regulation of myoblast differentiation (GO:0045662)3.57814950
43COPI coating of Golgi vesicle (GO:0048205)3.54389374
44Golgi transport vesicle coating (GO:0048200)3.54389374
45regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.53674477
46positive regulation of blood vessel endothelial cell migration (GO:0043536)3.51392976
47focal adhesion assembly (GO:0048041)3.47940392
48cell-substrate adherens junction assembly (GO:0007045)3.47940392
49cellular response to vitamin D (GO:0071305)3.46754505
50adherens junction assembly (GO:0034333)3.45896389
51mesenchymal-epithelial cell signaling (GO:0060638)3.45772002
52mesenchyme morphogenesis (GO:0072132)3.42306187
53negative regulation of mast cell activation (GO:0033004)3.41944516
54cell proliferation involved in metanephros development (GO:0072203)3.39899437
55protein localization to endosome (GO:0036010)3.37118885
56regulation of interleukin-8 secretion (GO:2000482)3.36116897
57heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.35520924
58lung epithelium development (GO:0060428)3.34884859
59protein retention in ER lumen (GO:0006621)3.33903493
60adhesion of symbiont to host cell (GO:0044650)3.32901661
61virion attachment to host cell (GO:0019062)3.32901661
62inner ear receptor cell differentiation (GO:0060113)3.31748140
63dermatan sulfate biosynthetic process (GO:0030208)3.30904665
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.30320233
65lung vasculature development (GO:0060426)3.30078145
66glycolipid catabolic process (GO:0019377)3.29978846
67cell migration involved in sprouting angiogenesis (GO:0002042)3.29147322
68positive regulation of osteoblast proliferation (GO:0033690)3.28334136
69vascular endothelial growth factor signaling pathway (GO:0038084)3.27755482
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.26968094
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.26632986
72negative regulation of chondrocyte differentiation (GO:0032331)3.24594047
73respiratory tube development (GO:0030323)3.24143148
74venous blood vessel morphogenesis (GO:0048845)3.24115646
75dermatan sulfate metabolic process (GO:0030205)3.22090983
76hypotonic response (GO:0006971)3.21976194
77collagen metabolic process (GO:0032963)3.21624234
78regulation of apoptotic process involved in morphogenesis (GO:1902337)3.21067048
79cell differentiation involved in metanephros development (GO:0072202)3.19888868
80atrioventricular valve morphogenesis (GO:0003181)3.19315223
81positive regulation of keratinocyte differentiation (GO:0045618)3.18786728
82response to muramyl dipeptide (GO:0032495)3.18558603
83ceramide catabolic process (GO:0046514)3.15945615
84muscle cell migration (GO:0014812)3.15811443
85response to peptidoglycan (GO:0032494)3.15746579
86retina vasculature morphogenesis in camera-type eye (GO:0061299)3.15021905
87pericardium development (GO:0060039)3.14968836
88planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12465105
89wound healing, spreading of cells (GO:0044319)3.12086800
90regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.11381241
91endothelial cell morphogenesis (GO:0001886)3.10362112
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.09647627
93stress fiber assembly (GO:0043149)3.09282061
94axon ensheathment in central nervous system (GO:0032291)3.08878570
95central nervous system myelination (GO:0022010)3.08878570
96protein hydroxylation (GO:0018126)3.06904703
97embryonic camera-type eye development (GO:0031076)3.06434095
98heart valve formation (GO:0003188)3.05766800
99collagen catabolic process (GO:0030574)3.02540122
100regulation of glomerular filtration (GO:0003093)3.02134018
101negative regulation of oligodendrocyte differentiation (GO:0048715)3.01791595
102positive regulation of endothelial cell apoptotic process (GO:2000353)3.01334449
103mesenchymal to epithelial transition (GO:0060231)3.01178638
104establishment of apical/basal cell polarity (GO:0035089)2.99451002
105multicellular organismal macromolecule metabolic process (GO:0044259)2.99337274
106superoxide anion generation (GO:0042554)2.96920904
107positive regulation of smoothened signaling pathway (GO:0045880)2.95328226
108negative regulation of astrocyte differentiation (GO:0048712)2.94169029
109negative regulation of smooth muscle cell migration (GO:0014912)2.92948982
110cell differentiation involved in kidney development (GO:0061005)2.89676660
111regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.86534805
112endosome to melanosome transport (GO:0035646)2.86372080
113endosome to pigment granule transport (GO:0043485)2.86372080
114mannosylation (GO:0097502)2.85553551
115extracellular matrix disassembly (GO:0022617)2.84303564
116neural crest cell development (GO:0014032)2.84266194
117adhesion of symbiont to host (GO:0044406)2.83930880
118substrate adhesion-dependent cell spreading (GO:0034446)2.82662116
119embryonic viscerocranium morphogenesis (GO:0048703)2.82521867
120lymphangiogenesis (GO:0001946)2.82285065
121multicellular organismal metabolic process (GO:0044236)2.82014635
122response to hepatocyte growth factor (GO:0035728)2.81582955
123cellular response to hepatocyte growth factor stimulus (GO:0035729)2.81582955
124cell proliferation involved in kidney development (GO:0072111)2.81536776
125midgut development (GO:0007494)2.81449611
126neutrophil activation involved in immune response (GO:0002283)2.80778130
127regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.80604602
128multicellular organismal catabolic process (GO:0044243)2.80547553
129presynaptic membrane organization (GO:0097090)2.80227838
130negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.79634248
131cochlea morphogenesis (GO:0090103)2.78989361
132regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.78437246
133mammary gland epithelial cell proliferation (GO:0033598)2.77993494
134smooth muscle tissue development (GO:0048745)2.77597287
135artery morphogenesis (GO:0048844)2.75883004
136embryonic digestive tract morphogenesis (GO:0048557)2.75553868
137presynaptic membrane assembly (GO:0097105)2.74724959
138mesenchymal cell development (GO:0014031)2.74552556
139regulation of mesenchymal cell apoptotic process (GO:2001053)2.71289340
140negative regulation of osteoblast proliferation (GO:0033689)2.71012059
141detection of molecule of bacterial origin (GO:0032490)2.70612608
142cartilage morphogenesis (GO:0060536)2.70093190
143chondroitin sulfate biosynthetic process (GO:0030206)2.69890071
144cranial nerve structural organization (GO:0021604)2.69725204
145sequestering of actin monomers (GO:0042989)2.69537086
146positive regulation of Rho protein signal transduction (GO:0035025)2.68650720
147mammary gland epithelial cell differentiation (GO:0060644)2.68050693
148centriole assembly (GO:0098534)2.66434189
149tooth mineralization (GO:0034505)2.66417359
150lung secretory cell differentiation (GO:0061140)2.66281564
151positive regulation of axon extension (GO:0045773)2.65832199
152peptidyl-proline hydroxylation (GO:0019511)2.65590565
153regulation of smooth muscle cell migration (GO:0014910)2.65567405
154polarized epithelial cell differentiation (GO:0030859)2.65352541
155type B pancreatic cell development (GO:0003323)2.64250765
156detection of biotic stimulus (GO:0009595)2.63587046
157mechanoreceptor differentiation (GO:0042490)2.63105166
158muscle cell fate commitment (GO:0042693)2.62535238
159regulation of dendritic cell antigen processing and presentation (GO:0002604)2.61375194
160dorsal/ventral neural tube patterning (GO:0021904)2.60404814
161sequestering of metal ion (GO:0051238)2.58817575
162negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.55941869
163negative regulation of myotube differentiation (GO:0010832)2.55369066
164amyloid precursor protein catabolic process (GO:0042987)2.54372942
165daunorubicin metabolic process (GO:0044597)2.52485285
166polyketide metabolic process (GO:0030638)2.52485285
167doxorubicin metabolic process (GO:0044598)2.52485285
168kidney mesenchyme development (GO:0072074)2.50762908
169intraciliary transport (GO:0042073)2.49841478
170negative regulation of homotypic cell-cell adhesion (GO:0034111)2.46280379
171negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.46200122
172regulation of myoblast differentiation (GO:0045661)2.46101682
173positive regulation of cellular amide metabolic process (GO:0034250)2.44964672
174negative chemotaxis (GO:0050919)2.44276836
175positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.44013842
176postsynaptic membrane organization (GO:0001941)2.43813271
177metanephric mesenchyme development (GO:0072075)2.43064344
178lens morphogenesis in camera-type eye (GO:0002089)2.42988465
179negative regulation of stem cell proliferation (GO:2000647)2.42607751
180sequestering of extracellular ligand from receptor (GO:0035581)2.42025108
181phagocytosis, engulfment (GO:0006911)2.41517894
182negative regulation of axon guidance (GO:1902668)2.39838002
183synapsis (GO:0007129)2.39345738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse4.83644888
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.13676855
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.28904948
4TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.20854289
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.07006150
6RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.98124905
7* ELK3_25401928_ChIP-Seq_HUVEC_Human2.92648306
8GBX2_23144817_ChIP-Seq_PC3_Human2.89604612
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.78933475
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.77017042
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65008025
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58097244
13* BRD4_25478319_ChIP-Seq_HGPS_Human2.54453981
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47481268
15CLOCK_20551151_ChIP-Seq_293T_Human2.42675109
16* CBX2_27304074_Chip-Seq_ESCs_Mouse2.38167527
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.32224065
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29982401
19TP53_22127205_ChIP-Seq_IMR90_Human2.27732199
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.21863593
21* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18904795
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12973014
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.12557385
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12449269
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09941689
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09819769
27SUZ12_27294783_Chip-Seq_NPCs_Mouse2.09167079
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08158812
29* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.07873472
30ZNF263_19887448_ChIP-Seq_K562_Human2.05985384
31ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.03416586
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.99932223
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.98143435
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.98143435
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.97785388
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.97429620
37* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96669360
38* TP53_18474530_ChIP-ChIP_U2OS_Human1.93359108
39* UBF1/2_26484160_Chip-Seq_HMECs_Human1.91274024
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89180234
41* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87444661
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.84045819
43* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83439193
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83050560
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.82793389
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.82283120
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81669221
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.79857101
49* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.78487674
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77431683
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.77355751
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.76428671
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.75712174
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.75625328
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.72474526
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70880919
57RACK7_27058665_Chip-Seq_MCF-7_Human1.70724271
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70517951
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68170321
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.67873570
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.64817779
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64187216
63P300_19829295_ChIP-Seq_ESCs_Human1.64023325
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62704680
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60645818
66* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59842090
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59731733
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58940828
69P53_22387025_ChIP-Seq_ESCs_Mouse1.58155503
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57991607
71JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57756885
72* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57489818
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55739629
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.55708606
75LXR_22292898_ChIP-Seq_THP-1_Human1.55656372
76SUZ12_18555785_Chip-Seq_ESCs_Mouse1.55442385
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54080154
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53265223
79* ATF3_27146783_Chip-Seq_COLON_Human1.53031823
80* EP300_21415370_ChIP-Seq_HL-1_Mouse1.52929147
81* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52684396
82* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52684396
83* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50702603
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.49065003
85ZFX_18555785_Chip-Seq_ESCs_Mouse1.48917914
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48822000
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47992196
88* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47660103
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.47429068
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46607778
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.45024779
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.43988872
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41817203
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.40798750
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.40179042
96* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40053152
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38320155
98EZH2_22144423_ChIP-Seq_EOC_Human1.38116848
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37821616
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.37693113
101PU1_27457419_Chip-Seq_LIVER_Mouse1.37220023
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36777278
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.36126987
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.36006976
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35676084
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34941712
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34826313
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.34387898
109SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33857607
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33584274
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33072622
112* TP53_23651856_ChIP-Seq_MEFs_Mouse1.31718915
113* TP53_20018659_ChIP-ChIP_R1E_Mouse1.31054206
114* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.30915603
115* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30362755
116* EZH2_27294783_Chip-Seq_ESCs_Mouse1.29565724
117RNF2_27304074_Chip-Seq_NSC_Mouse1.29090078
118NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28211701
119TP53_16413492_ChIP-PET_HCT116_Human1.27777139
120* SA1_22415368_ChIP-Seq_MEFs_Mouse1.27766241
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25978123
122CJUN_26792858_Chip-Seq_BT549_Human1.25816752
123ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25210353
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24540105
125KDM2B_26808549_Chip-Seq_K562_Human1.24482823
126NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24383724
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24383724
128ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22917983
129KLF4_18555785_Chip-Seq_ESCs_Mouse1.22452001
130OCT4_18555785_Chip-Seq_ESCs_Mouse1.21543725
131TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21260613
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20332299
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20108323
134ESR1_21235772_ChIP-Seq_MCF-7_Human1.19954215
135ER_23166858_ChIP-Seq_MCF-7_Human1.19605660
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19260096
137P300_18555785_Chip-Seq_ESCs_Mouse1.18451300
138* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17825712
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17690319
140GATA2_21666600_ChIP-Seq_HMVEC_Human1.17650620
141PIAS1_25552417_ChIP-Seq_VCAP_Human1.17643588
142POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17264260
143SMAD4_21799915_ChIP-Seq_A2780_Human1.16974102
144CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16448002
145IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16360007
146TBX20_22080862_ChIP-Seq_HEART_Mouse1.15346291
147TBX20_22328084_ChIP-Seq_HEART_Mouse1.15346291
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14088186
149SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13726300
150* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11751740
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11730789
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10776489
153* RNF2_27304074_Chip-Seq_ESCs_Mouse1.10464148
154TAL1_26923725_Chip-Seq_HPCs_Mouse1.08605952
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07839364
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07047740
157SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06863344
158KDM2B_26808549_Chip-Seq_JURKAT_Human1.06851108
159P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06848365
160TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06687041
161EWS_26573619_Chip-Seq_HEK293_Human1.05722722
162TCF4_18268006_ChIP-ChIP_LS174T_Human1.05131214
163SMAD3_21741376_ChIP-Seq_EPCs_Human1.04680789
164OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04487566
165CTCF_18555785_Chip-Seq_ESCs_Mouse1.03882704
166ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02938172
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02845595
168ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02768357
169ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00940516
170FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99394609
171ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99155311
172EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98840492
173AR_21909140_ChIP-Seq_LNCAP_Human0.97780700
174EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97731684
175* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96990151
176SOX2_20726797_ChIP-Seq_SW620_Human0.95492827
177NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94515326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.41765135
2MP0003705_abnormal_hypodermis_morpholog4.74337747
3MP0010030_abnormal_orbit_morphology4.17276703
4MP0009780_abnormal_chondrocyte_physiolo3.35003503
5MP0005257_abnormal_intraocular_pressure3.19269236
6MP0002102_abnormal_ear_morphology3.17647353
7MP0003566_abnormal_cell_adhesion3.16586558
8MP0001986_abnormal_taste_sensitivity3.07667500
9MP0003941_abnormal_skin_development2.97054776
10MP0009384_cardiac_valve_regurgitation2.88120818
11MP0003950_abnormal_plasma_membrane2.64329185
12MP0005275_abnormal_skin_tensile2.62042953
13MP0010386_abnormal_urinary_bladder2.54588295
14MP0000049_abnormal_middle_ear2.46123644
15MP0003091_abnormal_cell_migration2.38095092
16MP0001188_hyperpigmentation2.31873506
17MP0002249_abnormal_larynx_morphology2.29779221
18MP0005623_abnormal_meninges_morphology2.21830886
19MP0003880_abnormal_central_pattern2.14879821
20MP0001958_emphysema2.14597783
21MP0008260_abnormal_autophagy2.11165524
22MP0005503_abnormal_tendon_morphology2.02914675
23MP0004134_abnormal_chest_morphology2.00610925
24MP0000013_abnormal_adipose_tissue1.93093364
25MP0005023_abnormal_wound_healing1.91918403
26MP0000751_myopathy1.91755560
27MP0002938_white_spotting1.91494633
28MP0005423_abnormal_somatic_nervous1.89832982
29MP0000534_abnormal_ureter_morphology1.88961630
30MP0003283_abnormal_digestive_organ1.82811984
31MP0003938_abnormal_ear_development1.81207391
32MP0000678_abnormal_parathyroid_gland1.80621185
33MP0004381_abnormal_hair_follicle1.79668973
34MP0005171_absent_coat_pigmentation1.77572410
35MP0004272_abnormal_basement_membrane1.75294754
36MP0002060_abnormal_skin_morphology1.66085895
37MP0000762_abnormal_tongue_morphology1.64275509
38MP0003385_abnormal_body_wall1.63635994
39MP0002148_abnormal_hypersensitivity_rea1.62474159
40MP0005595_abnormal_vascular_smooth1.62376022
41MP0009053_abnormal_anal_canal1.61407653
42MP0009250_abnormal_appendicular_skeleto1.59206979
43MP0006054_spinal_hemorrhage1.58863036
44MP0000733_abnormal_muscle_development1.57839402
45MP0002896_abnormal_bone_mineralization1.56051394
46MP0001849_ear_inflammation1.53985131
47MP0005164_abnormal_response_to1.50549035
48MP0010352_gastrointestinal_tract_polyps1.49007717
49MP0001835_abnormal_antigen_presentation1.48144084
50MP0008438_abnormal_cutaneous_collagen1.44739070
51MP0005508_abnormal_skeleton_morphology1.41782656
52MP0005220_abnormal_exocrine_pancreas1.40951486
53MP0001299_abnormal_eye_distance/1.40345892
54MP0003183_abnormal_peptide_metabolism1.38048687
55MP0002877_abnormal_melanocyte_morpholog1.35341332
56MP0003937_abnormal_limbs/digits/tail_de1.30793530
57MP0002177_abnormal_outer_ear1.29050347
58MP0009840_abnormal_foam_cell1.28012765
59MP0005058_abnormal_lysosome_morphology1.25071741
60MP0002751_abnormal_autonomic_nervous1.24839196
61MP0003942_abnormal_urinary_system1.24020685
62MP0003755_abnormal_palate_morphology1.22293905
63MP0005197_abnormal_uvea_morphology1.21448178
64MP0001270_distended_abdomen1.21396325
65MP0000163_abnormal_cartilage_morphology1.20424068
66MP0001243_abnormal_dermal_layer1.20069859
67MP0000383_abnormal_hair_follicle1.19502293
68MP0000681_abnormal_thyroid_gland1.14403821
69MP0000537_abnormal_urethra_morphology1.09429599
70MP0000538_abnormal_urinary_bladder1.09408954
71MP0003724_increased_susceptibility_to1.08815475
72MP0002998_abnormal_bone_remodeling1.07006862
73MP0002108_abnormal_muscle_morphology1.06934136
74MP0004133_heterotaxia1.06653429
75MP0010368_abnormal_lymphatic_system1.05999892
76MP0001915_intracranial_hemorrhage1.05915892
77MP0000749_muscle_degeneration1.05358513
78MP0003115_abnormal_respiratory_system1.04749184
79MP0004858_abnormal_nervous_system1.04510424
80MP0000026_abnormal_inner_ear1.03934996
81MP0001879_abnormal_lymphatic_vessel1.03651191
82MP0000428_abnormal_craniofacial_morphol1.03104328
83MP0002113_abnormal_skeleton_development1.02950481
84MP0000015_abnormal_ear_pigmentation1.02271124
85MP0003448_altered_tumor_morphology1.02105458
86MP0003279_aneurysm1.01972515
87MP0005390_skeleton_phenotype1.01520913
88MP0005076_abnormal_cell_differentiation1.01146292
89MP0002115_abnormal_skeleton_extremities0.99802471
90MP0000750_abnormal_muscle_regeneration0.99514307
91MP0000003_abnormal_adipose_tissue0.98005808
92MP0004782_abnormal_surfactant_physiolog0.97966799
93MP0002233_abnormal_nose_morphology0.97709542
94MP0000759_abnormal_skeletal_muscle0.95689215
95MP0001614_abnormal_blood_vessel0.94385438
96MP0000685_abnormal_immune_system0.94297371
97MP0002277_abnormal_respiratory_mucosa0.93194579
98MP0002128_abnormal_blood_circulation0.93151597
99MP0002109_abnormal_limb_morphology0.92546459
100MP0009697_abnormal_copulation0.92501551
101MP0005174_abnormal_tail_pigmentation0.92362789
102MP0000462_abnormal_digestive_system0.91587424
103MP0001348_abnormal_lacrimal_gland0.90821193
104* MP0000490_abnormal_crypts_of0.90583526
105MP0002295_abnormal_pulmonary_circulatio0.88132444
106MP0002419_abnormal_innate_immunity0.87343952
107MP0004883_abnormal_blood_vessel0.85801463
108MP0004510_myositis0.84729955
109MP0002116_abnormal_craniofacial_bone0.84342163
110MP0000569_abnormal_digit_pigmentation0.83375256
111MP0002089_abnormal_postnatal_growth/wei0.82309092
112MP0001175_abnormal_lung_morphology0.82034282
113MP0002933_joint_inflammation0.82007991
114MP0002925_abnormal_cardiovascular_devel0.80284070
115MP0002932_abnormal_joint_morphology0.79830835
116MP0000647_abnormal_sebaceous_gland0.79550537
117MP0001293_anophthalmia0.78647953
118MP0000432_abnormal_head_morphology0.78405840
119MP0003787_abnormal_imprinting0.78193907
120MP0005165_increased_susceptibility_to0.76975425
121MP0005670_abnormal_white_adipose0.76431290
122MP0000858_altered_metastatic_potential0.75927466
123MP0003122_maternal_imprinting0.74979928
124MP0003935_abnormal_craniofacial_develop0.74738971
125MP0003136_yellow_coat_color0.74722472
126MP0002254_reproductive_system_inflammat0.74375797
127MP0001533_abnormal_skeleton_physiology0.74329828
128MP0003828_pulmonary_edema0.73776810
129MP0005464_abnormal_platelet_physiology0.73050861
130MP0005379_endocrine/exocrine_gland_phen0.72982903
131MP0001542_abnormal_bone_strength0.72750757
132MP0005000_abnormal_immune_tolerance0.72713330
133MP0000467_abnormal_esophagus_morphology0.71454063
134MP0005620_abnormal_muscle_contractility0.71290232
135MP0006138_congestive_heart_failure0.70669354
136MP0002163_abnormal_gland_morphology0.69623501
137MP0001186_pigmentation_phenotype0.68953113
138MP0001944_abnormal_pancreas_morphology0.68733135
139MP0000767_abnormal_smooth_muscle0.67533508
140MP0005621_abnormal_cell_physiology0.67032064
141MP0009785_altered_susceptibility_to0.66924429
142MP0002693_abnormal_pancreas_physiology0.66838620
143MP0006276_abnormal_autonomic_nervous0.66620705
144MP0003795_abnormal_bone_structure0.64758241
145MP0003436_decreased_susceptibility_to0.63955004
146MP0003191_abnormal_cellular_cholesterol0.63541065
147MP0004087_abnormal_muscle_fiber0.62835696
148MP0006072_abnormal_retinal_apoptosis0.61698269
149MP0000249_abnormal_blood_vessel0.60602282
150MP0002876_abnormal_thyroid_physiology0.60096530
151MP0005193_abnormal_anterior_eye0.60024967
152MP0004233_abnormal_muscle_weight0.60019353
153MP0001286_abnormal_eye_development0.59037927
154MP0000343_altered_response_to0.58687839
155MP0004808_abnormal_hematopoietic_stem0.57463915
156MP0005409_darkened_coat_color0.57258507
157MP0002114_abnormal_axial_skeleton0.55080295
158MP0003453_abnormal_keratinocyte_physiol0.54099127
159MP0005360_urolithiasis0.53840209

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)5.03501268
2Aortic dissection (HP:0002647)4.91870323
3Ankle contracture (HP:0006466)4.85689763
4Vascular tortuosity (HP:0004948)4.77695826
5Aortic aneurysm (HP:0004942)4.75072272
6Arterial tortuosity (HP:0005116)4.65356669
7Type 1 muscle fiber predominance (HP:0003803)4.40099925
8Follicular hyperkeratosis (HP:0007502)4.39030569
9Spinal rigidity (HP:0003306)4.16918579
10Atrophic scars (HP:0001075)4.05949927
11Recurrent corneal erosions (HP:0000495)4.05740054
12Fragile skin (HP:0001030)3.97959157
13Bladder diverticulum (HP:0000015)3.85252462
14Soft skin (HP:0000977)3.83476195
15Xerostomia (HP:0000217)3.66009559
16Slender build (HP:0001533)3.54117394
17Wormian bones (HP:0002645)3.53559504
18Spondylolisthesis (HP:0003302)3.41201143
19Abnormality of incisor morphology (HP:0011063)3.36914308
20Genu recurvatum (HP:0002816)3.33057993
21Broad metatarsal (HP:0001783)3.31764131
22Intestinal atresia (HP:0011100)3.25864967
23Cervical subluxation (HP:0003308)3.23541388
24True hermaphroditism (HP:0010459)3.17510089
25Mildly elevated creatine phosphokinase (HP:0008180)3.09924491
26Partial duplication of thumb phalanx (HP:0009944)3.05198638
27Vertebral compression fractures (HP:0002953)3.04210050
28Blue sclerae (HP:0000592)3.03825289
29Nasolacrimal duct obstruction (HP:0000579)3.00942240
30Shallow orbits (HP:0000586)2.99760684
31Elbow flexion contracture (HP:0002987)2.96755710
32Conical tooth (HP:0000698)2.87233236
33Hypoventilation (HP:0002791)2.86619504
34Aortic regurgitation (HP:0001659)2.86418015
35Mitral valve prolapse (HP:0001634)2.85273330
36Protrusio acetabuli (HP:0003179)2.82509055
37Dilatation of the ascending aorta (HP:0005111)2.79866202
38Abnormality of the right ventricle (HP:0001707)2.78778784
39Alacrima (HP:0000522)2.78218910
40Partial duplication of the phalanx of hand (HP:0009999)2.71828591
41Increased variability in muscle fiber diameter (HP:0003557)2.70797579
42Distal lower limb amyotrophy (HP:0008944)2.70249077
43Aplasia involving bones of the upper limbs (HP:0009823)2.69578952
44Aplasia of the phalanges of the hand (HP:0009802)2.69578952
45Aplasia involving bones of the extremities (HP:0009825)2.69578952
46Peritonitis (HP:0002586)2.67230020
47Achilles tendon contracture (HP:0001771)2.66971941
48Bowel diverticulosis (HP:0005222)2.66581227
49Joint laxity (HP:0001388)2.60114995
50Ulnar bowing (HP:0003031)2.58260014
51Long toe (HP:0010511)2.54150634
52Decreased lacrimation (HP:0000633)2.54084139
53Biconcave vertebral bodies (HP:0004586)2.53546858
54Metaphyseal dysplasia (HP:0100255)2.52514678
55Disproportionate tall stature (HP:0001519)2.51836398
56Overgrowth (HP:0001548)2.51328444
57Duplication of thumb phalanx (HP:0009942)2.50110807
58Hypoalbuminemia (HP:0003073)2.49108136
59Abnormal albumin level (HP:0012116)2.49108136
60Abnormality of the lacrimal duct (HP:0011481)2.48773039
61Osteomalacia (HP:0002749)2.48023820
62Coronal craniosynostosis (HP:0004440)2.47922932
63Retinal dysplasia (HP:0007973)2.47536217
64Short nail (HP:0001799)2.46784582
65Distal upper limb amyotrophy (HP:0007149)2.45435494
66Upper limb amyotrophy (HP:0009129)2.45435494
67Type I transferrin isoform profile (HP:0003642)2.43338033
68Pancreatic fibrosis (HP:0100732)2.43251407
69Congenital primary aphakia (HP:0007707)2.42875923
70Cerebral aneurysm (HP:0004944)2.41664627
71Renal duplication (HP:0000075)2.40557795
72Gait imbalance (HP:0002141)2.40180649
73Germ cell neoplasia (HP:0100728)2.38270880
74Generalized amyotrophy (HP:0003700)2.38120739
75Preaxial hand polydactyly (HP:0001177)2.37948313
76Abnormality of skeletal muscle fiber size (HP:0012084)2.37143261
77Mitral regurgitation (HP:0001653)2.37038894
78Hyperextensible skin (HP:0000974)2.36811717
79Aplasia of the musculature (HP:0100854)2.36340076
80Ectopia lentis (HP:0001083)2.35675721
81Aneurysm (HP:0002617)2.35622640
82Medial flaring of the eyebrow (HP:0010747)2.35096946
83Increased connective tissue (HP:0009025)2.34887135
84Glomerulonephritis (HP:0000099)2.34875313
85Abnormality of the Achilles tendon (HP:0005109)2.34091553
86Abnormality of the nasolacrimal system (HP:0000614)2.31012403
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.30705131
88Osteolytic defects of the hand bones (HP:0009699)2.30705131
89Wrist flexion contracture (HP:0001239)2.30523156
90Aplasia/Hypoplasia of the lens (HP:0008063)2.30120871
91Neonatal respiratory distress (HP:0002643)2.30015968
92Thickened helices (HP:0000391)2.28289589
93Nephrogenic diabetes insipidus (HP:0009806)2.28249138
94Abnormality of the fetal cardiovascular system (HP:0010948)2.27620195
95Abnormal umbilical cord blood vessels (HP:0011403)2.27620195
96Abnormal protein glycosylation (HP:0012346)2.25703995
97Abnormal glycosylation (HP:0012345)2.25703995
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25703995
99Abnormal protein N-linked glycosylation (HP:0012347)2.25703995
100Premature rupture of membranes (HP:0001788)2.25004249
101Camptodactyly of toe (HP:0001836)2.22404364
102Decreased central vision (HP:0007663)2.21870096
103Corneal erosion (HP:0200020)2.20010150
104Abnormality of the middle phalanges of the toes (HP:0010183)2.19817338
105Abnormality of the acetabulum (HP:0003170)2.19269559
106Cheilitis (HP:0100825)2.18786658
107Occipital encephalocele (HP:0002085)2.18137468
108Stage 5 chronic kidney disease (HP:0003774)2.15926351
109Premature skin wrinkling (HP:0100678)2.14498845
110Syringomyelia (HP:0003396)2.11762055
111Spinal cord lesions (HP:0100561)2.11762055
112Mesangial abnormality (HP:0001966)2.11271626
113Fibular hypoplasia (HP:0003038)2.10983763
114Lower limb amyotrophy (HP:0007210)2.10664402
115Abnormality of the umbilical cord (HP:0010881)2.09479806
116Abnormal delivery (HP:0001787)2.08980985
117Gastrointestinal atresia (HP:0002589)2.08507614
118Wide anterior fontanel (HP:0000260)2.08181871
119Abnormality of dentin (HP:0010299)2.07810943
120Congenital sensorineural hearing impairment (HP:0008527)2.06886562
121Embryonal neoplasm (HP:0002898)2.03521845
122Natal tooth (HP:0000695)2.02956232
123Limb-girdle muscle weakness (HP:0003325)2.01020343
124Hydroureter (HP:0000072)2.00201420
125Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00064978
126Aplasia cutis congenita (HP:0001057)1.98476798
127Abnormality of molar morphology (HP:0011070)1.98061804
128Abnormality of molar (HP:0011077)1.98061804
129Genital tract atresia (HP:0001827)1.96187327
130Cardiovascular calcification (HP:0011915)1.95828983
131Round ear (HP:0100830)1.95419609
132Hyperacusis (HP:0010780)1.95009572
133Protruding ear (HP:0000411)1.94344097
134Mixed hearing impairment (HP:0000410)1.91528955
135Abnormal ossification of hand bones (HP:0005921)1.91094336
136Flexion contracture of toe (HP:0005830)1.90778733
137Joint contractures involving the joints of the feet (HP:0100492)1.90778733
138Chromsome breakage (HP:0040012)1.90377307
139Deviation of the hallux (HP:0010051)1.90131134
140Joint stiffness (HP:0001387)1.89354309
141Hallux valgus (HP:0001822)1.89198882
142Mitral stenosis (HP:0001718)1.89043406
143Aortic valve stenosis (HP:0001650)1.88426399
144Bowed forearm bones (HP:0003956)1.88081143
145Bowing of the arm (HP:0006488)1.88081143
146Abnormality of the incisor (HP:0000676)1.87677527
147Abnormality of the costochondral junction (HP:0000919)1.86849494
148Infantile muscular hypotonia (HP:0008947)1.86434884
149Abnormality of the dental root (HP:0006486)1.85527522
150Taurodontia (HP:0000679)1.85527522
151Abnormality of permanent molar morphology (HP:0011071)1.85527522
152Optic nerve hypoplasia (HP:0000609)1.85341247
153Spinal canal stenosis (HP:0003416)1.84568834
154Hypodontia (HP:0000668)1.84407558
155Nonprogressive disorder (HP:0003680)1.83408989
156Knee flexion contracture (HP:0006380)1.83286695
157Renal Fanconi syndrome (HP:0001994)1.82479780
158Nephrotic syndrome (HP:0000100)1.80890024
159Palpebral edema (HP:0100540)1.79603683
160Abnormality of the lumbar spine (HP:0100712)1.79286407
161Difficulty climbing stairs (HP:0003551)1.78388202
162Abnormal hair whorl (HP:0010721)1.78177039
163Tubular atrophy (HP:0000092)1.78121056
164Reduced subcutaneous adipose tissue (HP:0003758)1.77961068
165Vaginal atresia (HP:0000148)1.77477623
166Down-sloping shoulders (HP:0200021)1.77065332
167Patchy hypopigmentation of hair (HP:0011365)1.76652399
168Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76530315
169Hypoplastic scapulae (HP:0000882)1.76530315
170Recurrent abscess formation (HP:0002722)1.74439969
171Abnormality of renal resorption (HP:0011038)1.74103369
172Focal segmental glomerulosclerosis (HP:0000097)1.73864110
173Congenital hepatic fibrosis (HP:0002612)1.73713044
174Broad face (HP:0000283)1.72790116
175Coxa vara (HP:0002812)1.72315010
176Renal cortical cysts (HP:0000803)1.72153427
177Nephritis (HP:0000123)1.71397313
178Venous abnormality (HP:0002624)1.70444225
179Breech presentation (HP:0001623)1.70215652
180Arachnodactyly (HP:0001166)1.70020647
181Flat cornea (HP:0007720)1.69444628
182Duplicated collecting system (HP:0000081)1.69149339
183Abnormality of the dental pulp (HP:0006479)1.69091773
184Distal lower limb muscle weakness (HP:0009053)1.68167500
185Abnormality of the renal collecting system (HP:0004742)1.68023937
186Congenital hip dislocation (HP:0001374)1.67633870
187Mild short stature (HP:0003502)1.67506869
188Abnormality of the fibula (HP:0002991)1.67479173
189Abnormal ciliary motility (HP:0012262)1.67266115
190Ovoid vertebral bodies (HP:0003300)1.67080050
191Abnormality of the pulmonary veins (HP:0011718)1.66376891
192Single umbilical artery (HP:0001195)1.65973700

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.49718922
2PDGFRA3.95486021
3IRAK33.62395250
4ERBB33.59245875
5ADRBK23.27952971
6TTN3.18715930
7CASK3.17096912
8MST1R3.06145865
9PTK22.98249764
10IRAK42.90487564
11ZAK2.75479582
12FGFR32.71516777
13MAPK152.66499635
14NTRK12.64068593
15MET2.63759634
16SIK12.56641958
17DDR22.43446027
18PAK22.29662250
19SIK32.23426244
20TRIB32.22805426
21ERBB42.17063098
22ERN12.06485879
23IRAK12.06360796
24NME21.91543409
25LIMK11.86533541
26EPHB21.85192456
27LATS21.83754071
28CDK81.75044737
29INSRR1.62284044
30FLT31.61662203
31MYLK1.55232066
32KIT1.53505829
33TESK11.53235506
34ICK1.53020347
35TXK1.52956038
36IRAK21.51464681
37CLK11.49593024
38AKT31.49589280
39GRK71.48759913
40MOS1.47563329
41TRPM71.44866035
42LMTK21.44041382
43BMPR21.43090091
44YES11.42841463
45EIF2AK31.40385153
46DYRK31.40212279
47MAP3K141.35835171
48RIPK11.32481659
49PDGFRB1.28549151
50LATS11.24515758
51STK381.23139608
52EPHB11.22310791
53NEK91.20729802
54ABL21.15679440
55CDK31.14004623
56TLK11.11652408
57EIF2AK21.09635559
58PASK1.07371792
59TEC1.07148032
60SGK21.06658683
61TNIK1.04787816
62MAP3K31.01676041
63STK161.00603323
64CDK190.99885635
65EPHA20.99642080
66SMG10.98954127
67TIE10.98272423
68MELK0.96597411
69SIK20.95779380
70MTOR0.95336983
71ILK0.94644614
72DAPK30.93759262
73PRPF4B0.93673392
74DYRK1B0.93143846
75PDK20.92646888
76CAMKK20.91770993
77VRK10.86704955
78STK38L0.86006943
79PKN20.84432396
80PTK60.83046906
81CCNB10.80696226
82CDK120.79648056
83JAK30.78375788
84PAK60.77474051
85GRK50.76198957
86MUSK0.76195287
87ROCK10.75604893
88PNCK0.75011867
89GSK3A0.74059320
90STK240.73604068
91RPS6KA50.73512020
92SGK4940.73273575
93SGK2230.73273575
94MAP3K100.72076387
95NUAK10.71769237
96TGFBR20.71248631
97FGFR10.70940257
98TAOK20.70126239
99EIF2AK10.68011369
100PIM20.67321635
101MKNK10.66115096
102RPS6KA40.66043851
103MAP2K30.64465503
104PLK40.63333329
105PAK10.61949484
106ARAF0.59572924
107CHUK0.56660507
108BLK0.55039803
109PLK20.54151600
110MAPKAPK20.53026454
111BTK0.51780163
112MAPKAPK50.50861704
113MAPK130.50549186
114PAK40.50047682
115MAP3K80.49551671
116IKBKB0.48148400
117WNK10.47078321
118EEF2K0.46851144
119FER0.46098829
120CDC42BPA0.45835887
121TESK20.45595123
122RPS6KA20.44823429
123STK30.44716456
124SRPK10.44194751
125TTK0.44116317
126PRKCD0.44064543
127MAP2K10.43863836
128FRK0.43116299
129CAMK2B0.41305610
130PDPK10.40203598
131LYN0.39481231
132CDK90.39058385
133MAPK110.39025351
134NLK0.38935151
135OXSR10.38593173
136BMPR1B0.37388630
137PRKCE0.37091317
138DMPK0.36525837
139IGF1R0.36061970
140BCKDK0.35719775
141PRKD20.34706390
142CSK0.34050014
143CAMK2G0.33951836
144PIK3CG0.33926440
145MAP3K70.33753344
146MAPK70.33542051
147ADRBK10.33473227
148PTK2B0.32404107
149RPS6KC10.30474911
150RPS6KL10.30474911
151STK100.30331931
152MAP2K20.29699238
153BRAF0.29629520
154ROCK20.28740356
155NEK20.28082765
156BMX0.28080961
157PRKD10.27799840
158MAP3K130.27025099
159CDK70.26437103
160AURKA0.25914267
161PRKCZ0.25835364
162PRKG20.25004123
163MAP2K70.24344502
164CSF1R0.24170340
165MAPKAPK30.24004054
166MAP3K110.24001582
167ZAP700.21534669
168PRKD30.20270121
169AURKB0.18734797

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.62389624
2SNARE interactions in vesicular transport_Homo sapiens_hsa041302.42345755
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.38392656
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.15239438
5Other glycan degradation_Homo sapiens_hsa005112.11681810
6Hedgehog signaling pathway_Homo sapiens_hsa043401.84863347
7Basal cell carcinoma_Homo sapiens_hsa052171.70891600
8N-Glycan biosynthesis_Homo sapiens_hsa005101.69093579
9Rheumatoid arthritis_Homo sapiens_hsa053231.68151337
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60768251
11Phagosome_Homo sapiens_hsa041451.60172966
12Chronic myeloid leukemia_Homo sapiens_hsa052201.59778815
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.56289376
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.51264958
15MicroRNAs in cancer_Homo sapiens_hsa052061.50768125
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50071397
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48226438
18Melanoma_Homo sapiens_hsa052181.48019889
19Arachidonic acid metabolism_Homo sapiens_hsa005901.47878422
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46507648
21Leishmaniasis_Homo sapiens_hsa051401.42343410
22TGF-beta signaling pathway_Homo sapiens_hsa043501.42291317
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.38068796
24ECM-receptor interaction_Homo sapiens_hsa045121.32154726
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31648589
26Base excision repair_Homo sapiens_hsa034101.30195051
27Sulfur metabolism_Homo sapiens_hsa009201.28865794
28Homologous recombination_Homo sapiens_hsa034401.28580722
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26515543
30Sphingolipid metabolism_Homo sapiens_hsa006001.26363494
31Vibrio cholerae infection_Homo sapiens_hsa051101.25421418
32Sulfur relay system_Homo sapiens_hsa041221.25066852
33Vitamin digestion and absorption_Homo sapiens_hsa049771.24123525
34Gap junction_Homo sapiens_hsa045401.22907608
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17915922
36Mismatch repair_Homo sapiens_hsa034301.16628626
37Glioma_Homo sapiens_hsa052141.14092593
38Regulation of autophagy_Homo sapiens_hsa041401.12830119
39Autoimmune thyroid disease_Homo sapiens_hsa053201.09624765
40Melanogenesis_Homo sapiens_hsa049161.09618225
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.05829752
42Notch signaling pathway_Homo sapiens_hsa043301.04482713
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02966887
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02880765
45Hematopoietic cell lineage_Homo sapiens_hsa046400.98851914
46Thyroid cancer_Homo sapiens_hsa052160.98786484
47Tuberculosis_Homo sapiens_hsa051520.98510859
48Malaria_Homo sapiens_hsa051440.97276946
49Prostate cancer_Homo sapiens_hsa052150.97045986
50Type I diabetes mellitus_Homo sapiens_hsa049400.96903921
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96811998
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96709972
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96217655
54Pancreatic cancer_Homo sapiens_hsa052120.95114337
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91254192
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89918336
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88815046
58Ether lipid metabolism_Homo sapiens_hsa005650.88550998
59Lysosome_Homo sapiens_hsa041420.88170415
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88024913
61Allograft rejection_Homo sapiens_hsa053300.87883248
62Protein digestion and absorption_Homo sapiens_hsa049740.85755632
63Fanconi anemia pathway_Homo sapiens_hsa034600.85282435
64Selenocompound metabolism_Homo sapiens_hsa004500.85020944
65Legionellosis_Homo sapiens_hsa051340.84691635
66Taste transduction_Homo sapiens_hsa047420.84572729
67Galactose metabolism_Homo sapiens_hsa000520.84569570
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83869412
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81301434
70Focal adhesion_Homo sapiens_hsa045100.80971528
71Tight junction_Homo sapiens_hsa045300.80737350
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80678337
73Endocytosis_Homo sapiens_hsa041440.79807340
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.79630196
75Graft-versus-host disease_Homo sapiens_hsa053320.79351638
76Complement and coagulation cascades_Homo sapiens_hsa046100.79153476
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78337162
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78118727
79Renal cell carcinoma_Homo sapiens_hsa052110.77281379
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76824461
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76166042
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75879504
83RNA polymerase_Homo sapiens_hsa030200.75793369
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75338597
85Prion diseases_Homo sapiens_hsa050200.74732209
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74261412
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.73903525
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72971190
89Serotonergic synapse_Homo sapiens_hsa047260.72769807
90Wnt signaling pathway_Homo sapiens_hsa043100.72746869
91Endometrial cancer_Homo sapiens_hsa052130.72407179
92Estrogen signaling pathway_Homo sapiens_hsa049150.71450370
93Hippo signaling pathway_Homo sapiens_hsa043900.70805065
94Adherens junction_Homo sapiens_hsa045200.70470087
95Dilated cardiomyopathy_Homo sapiens_hsa054140.70428351
96Antigen processing and presentation_Homo sapiens_hsa046120.70105528
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69506403
98p53 signaling pathway_Homo sapiens_hsa041150.69164326
99Rap1 signaling pathway_Homo sapiens_hsa040150.68115889
100TNF signaling pathway_Homo sapiens_hsa046680.67712349
101Purine metabolism_Homo sapiens_hsa002300.66838776
102Linoleic acid metabolism_Homo sapiens_hsa005910.66470418
103RNA degradation_Homo sapiens_hsa030180.65976988
104African trypanosomiasis_Homo sapiens_hsa051430.65840056
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.65150525
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65064342
107Pathways in cancer_Homo sapiens_hsa052000.64967077
108Amoebiasis_Homo sapiens_hsa051460.63102476
109Basal transcription factors_Homo sapiens_hsa030220.61582795
110Collecting duct acid secretion_Homo sapiens_hsa049660.61414871
111Bladder cancer_Homo sapiens_hsa052190.61391660
112HTLV-I infection_Homo sapiens_hsa051660.60872524
113Asthma_Homo sapiens_hsa053100.60732146
114Cocaine addiction_Homo sapiens_hsa050300.60575504
115Hepatitis B_Homo sapiens_hsa051610.60249883
116Viral carcinogenesis_Homo sapiens_hsa052030.59900134
117Shigellosis_Homo sapiens_hsa051310.59420381
118Non-small cell lung cancer_Homo sapiens_hsa052230.58669847
119Pyrimidine metabolism_Homo sapiens_hsa002400.58627899
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58304880
121Measles_Homo sapiens_hsa051620.57127702
122Proteoglycans in cancer_Homo sapiens_hsa052050.56977902
123Non-homologous end-joining_Homo sapiens_hsa034500.56610382
124Folate biosynthesis_Homo sapiens_hsa007900.56530470
125Alcoholism_Homo sapiens_hsa050340.56267378
126Pertussis_Homo sapiens_hsa051330.54775181
127ErbB signaling pathway_Homo sapiens_hsa040120.54757704
128Insulin secretion_Homo sapiens_hsa049110.54274971
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54259318
130Thyroid hormone synthesis_Homo sapiens_hsa049180.54164475
131Histidine metabolism_Homo sapiens_hsa003400.53751768
132Apoptosis_Homo sapiens_hsa042100.53137966
133Axon guidance_Homo sapiens_hsa043600.53124969
134Platelet activation_Homo sapiens_hsa046110.52315627
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52099538
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49788145
137Ras signaling pathway_Homo sapiens_hsa040140.49555797
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.49536807
139GnRH signaling pathway_Homo sapiens_hsa049120.48114707
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47977522
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47717586
142Small cell lung cancer_Homo sapiens_hsa052220.47652186
143Salmonella infection_Homo sapiens_hsa051320.47332148
144Pentose phosphate pathway_Homo sapiens_hsa000300.47201302
145Colorectal cancer_Homo sapiens_hsa052100.46543812
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46427071
147Fructose and mannose metabolism_Homo sapiens_hsa000510.46279534
148MAPK signaling pathway_Homo sapiens_hsa040100.45559652
149VEGF signaling pathway_Homo sapiens_hsa043700.42212989
150Toxoplasmosis_Homo sapiens_hsa051450.41324722
151mTOR signaling pathway_Homo sapiens_hsa041500.40308918
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.37887286
153Calcium signaling pathway_Homo sapiens_hsa040200.36811272
154Prolactin signaling pathway_Homo sapiens_hsa049170.35974021
155AMPK signaling pathway_Homo sapiens_hsa041520.35641567
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35553038

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