FOXL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to follicle-stimulating hormone stimulus (GO:0071372)9.93603804
2cellular response to cadmium ion (GO:0071276)9.19748453
3response to follicle-stimulating hormone (GO:0032354)7.51472906
4negative regulation of macrophage differentiation (GO:0045650)7.50086547
5glucocorticoid biosynthetic process (GO:0006704)7.01247282
6androgen metabolic process (GO:0008209)6.91830448
7mating behavior (GO:0007617)6.80575206
8cellular response to gonadotropin stimulus (GO:0071371)6.50022537
9hemoglobin metabolic process (GO:0020027)6.46831675
10progesterone metabolic process (GO:0042448)6.42001826
11C21-steroid hormone biosynthetic process (GO:0006700)6.18714623
12hormone biosynthetic process (GO:0042446)5.67461444
13extracellular matrix assembly (GO:0085029)5.42768903
14cellular response to antibiotic (GO:0071236)5.16262869
15response to gonadotropin (GO:0034698)5.02725958
16glucocorticoid metabolic process (GO:0008211)4.94383580
17uterus development (GO:0060065)4.82018569
18Leydig cell differentiation (GO:0033327)4.69914457
19response to insecticide (GO:0017085)4.66632219
20adhesion of symbiont to host (GO:0044406)4.64836939
21negative regulation of T cell differentiation in thymus (GO:0033085)4.45130761
22positive regulation of chondrocyte differentiation (GO:0032332)4.41298223
23embryonic camera-type eye morphogenesis (GO:0048596)4.32526838
24vitamin D metabolic process (GO:0042359)4.30689970
25epoxygenase P450 pathway (GO:0019373)4.27626487
26vitamin A metabolic process (GO:0006776)4.23441468
27positive regulation of cartilage development (GO:0061036)4.22154009
28response to phenylpropanoid (GO:0080184)4.20752668
29atrioventricular valve morphogenesis (GO:0003181)4.20664581
30response to vitamin E (GO:0033197)4.20225907
31smooth muscle tissue development (GO:0048745)4.07856030
32branching involved in salivary gland morphogenesis (GO:0060445)4.06984590
33positive regulation of gastrulation (GO:2000543)3.98618409
34positive regulation of male gonad development (GO:2000020)3.97282627
35somite development (GO:0061053)3.97037866
36ketone biosynthetic process (GO:0042181)3.86626821
37chondrocyte proliferation (GO:0035988)3.86006876
38seminiferous tubule development (GO:0072520)3.78708614
39regulation of interferon-gamma biosynthetic process (GO:0045072)3.78220116
40C21-steroid hormone metabolic process (GO:0008207)3.71929553
41* ovarian follicle development (GO:0001541)3.69531009
42cellular response to toxic substance (GO:0097237)3.66396810
43regulation of male gonad development (GO:2000018)3.66215878
44response to leptin (GO:0044321)3.65575258
45* embryonic eye morphogenesis (GO:0048048)3.64292270
46protein heterotrimerization (GO:0070208)3.62843622
47midgut development (GO:0007494)3.50879293
48positive regulation of osteoblast proliferation (GO:0033690)3.48160185
49cell migration involved in sprouting angiogenesis (GO:0002042)3.48118396
50hemidesmosome assembly (GO:0031581)3.46181501
51cellular response to interferon-alpha (GO:0035457)3.44838190
52nuclear pore complex assembly (GO:0051292)3.43577665
53negative regulation of cytokine biosynthetic process (GO:0042036)3.40399435
54endothelial cell chemotaxis (GO:0035767)3.40035392
55* sex determination (GO:0007530)3.39306871
56oocyte development (GO:0048599)3.32369715
57cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.24371870
58positive regulation of mesenchymal cell proliferation (GO:0002053)3.23044476
59skin morphogenesis (GO:0043589)3.21330670
60gonadal mesoderm development (GO:0007506)3.19408687
61regulation of steroid hormone biosynthetic process (GO:0090030)3.18370830
62activin receptor signaling pathway (GO:0032924)3.17146243
63gastrulation with mouth forming second (GO:0001702)3.14252355
64cellular response to leptin stimulus (GO:0044320)3.13785844
65negative regulation of alpha-beta T cell differentiation (GO:0046639)3.12902502
66positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.12707952
67positive regulation of T cell differentiation in thymus (GO:0033089)3.08632276
68head development (GO:0060322)3.07154694
69labyrinthine layer blood vessel development (GO:0060716)3.07005777
70regulation of translational fidelity (GO:0006450)3.06423101
71basement membrane organization (GO:0071711)3.05872822
72regulation of transforming growth factor beta2 production (GO:0032909)3.03643934
73estrogen biosynthetic process (GO:0006703)22.7866630
74regulation of cardioblast differentiation (GO:0051890)2.99320577
75positive regulation of smoothened signaling pathway (GO:0045880)2.97764962
76* ovulation cycle process (GO:0022602)2.97295732
77regulation of early endosome to late endosome transport (GO:2000641)2.95677558
78retina vasculature morphogenesis in camera-type eye (GO:0061299)2.95604367
79diaphragm development (GO:0060539)2.91800429
80anatomical structure regression (GO:0060033)2.89117458
81endocardial cushion development (GO:0003197)2.85917753
82COPI coating of Golgi vesicle (GO:0048205)2.85529421
83Golgi transport vesicle coating (GO:0048200)2.85529421
84dermatan sulfate biosynthetic process (GO:0030208)2.84213476
85response to corticosterone (GO:0051412)2.82804245
86endodermal cell differentiation (GO:0035987)2.81999659
87polarized epithelial cell differentiation (GO:0030859)2.80323688
88positive regulation of collagen biosynthetic process (GO:0032967)2.79734015
89regulation of chondrocyte differentiation (GO:0032330)2.78174256
90negative regulation of interferon-gamma production (GO:0032689)2.77694833
91mesodermal cell differentiation (GO:0048333)2.77434507
92female gonad development (GO:0008585)2.76732849
93regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.75380480
94regulation of cartilage development (GO:0061035)2.75281018
95dermatan sulfate metabolic process (GO:0030205)2.75064761
96regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74720708
97cell-substrate junction assembly (GO:0007044)2.73388176
98nuclear pore organization (GO:0006999)2.72152757
99cell adhesion mediated by integrin (GO:0033627)2.71854848
100morphogenesis of an epithelial sheet (GO:0002011)2.71061930
101regulation of mesenchymal cell proliferation (GO:0010464)2.70855866
102renal filtration (GO:0097205)2.70710140
103paraxial mesoderm development (GO:0048339)2.70355083
104embryonic digestive tract morphogenesis (GO:0048557)2.69144660
105establishment of apical/basal cell polarity (GO:0035089)2.67961029
106chondrocyte development (GO:0002063)2.67599951
107placenta blood vessel development (GO:0060674)2.67164620
108regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66311930
109desmosome organization (GO:0002934)2.64075577
110proteoglycan metabolic process (GO:0006029)2.61548810
111bone development (GO:0060348)2.60811271
112kidney mesenchyme development (GO:0072074)2.60801213
113glomerular filtration (GO:0003094)2.59838573
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.58863060
115positive regulation of collagen metabolic process (GO:0010714)2.58424683
116positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58167464
117atrial septum morphogenesis (GO:0060413)2.57984953
118negative regulation of catenin import into nucleus (GO:0035414)2.56894522
119renal system development (GO:0072001)2.56877404
120eyelid development in camera-type eye (GO:0061029)2.56536920
121glomerular basement membrane development (GO:0032836)2.55637063
122embryonic process involved in female pregnancy (GO:0060136)2.55166935
123regulation of macrophage differentiation (GO:0045649)2.54206800
124male genitalia development (GO:0030539)2.53531362
125regulation of endocrine process (GO:0044060)2.50638203
126collagen fibril organization (GO:0030199)2.50027010
127regulation of inositol phosphate biosynthetic process (GO:0010919)2.48398897
128embryonic skeletal system development (GO:0048706)2.47319855
129regulation of hormone biosynthetic process (GO:0046885)2.47272755
130embryonic foregut morphogenesis (GO:0048617)2.45891939
131response to lipoprotein particle (GO:0055094)2.45558054
132metanephric mesenchyme development (GO:0072075)2.44844413
133adhesion of symbiont to host cell (GO:0044650)2.44398671
134virion attachment to host cell (GO:0019062)2.44398671
135adherens junction assembly (GO:0034333)2.43533274
136embryonic skeletal joint morphogenesis (GO:0060272)2.43054925
137maternal process involved in female pregnancy (GO:0060135)2.42781871
138cytokine metabolic process (GO:0042107)2.42261430
139planar cell polarity pathway involved in neural tube closure (GO:0090179)2.41705893
140positive regulation of nitric-oxide synthase activity (GO:0051000)2.41672692
141response to mineralocorticoid (GO:0051385)2.41148515
142cellular hormone metabolic process (GO:0034754)2.41082845
143positive regulation of reproductive process (GO:2000243)2.40248632
144regulation of B cell differentiation (GO:0045577)2.38658293
145hippo signaling (GO:0035329)2.38358943
146negative regulation of fatty acid transport (GO:2000192)2.29875880
147gonad development (GO:0008406)2.29631067
148regulation of female gonad development (GO:2000194)2.29543591
149steroid biosynthetic process (GO:0006694)2.28298478
150response to cadmium ion (GO:0046686)2.28100914
151regulation of glomerular filtration (GO:0003093)2.27801859
152negative regulation of chondrocyte differentiation (GO:0032331)2.27734789
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.27056609
154multi-organism reproductive behavior (GO:0044705)2.26829419
155epithelial cell-cell adhesion (GO:0090136)2.24151145
156male gonad development (GO:0008584)2.22692461
157reproductive behavior (GO:0019098)2.20793762
158sequestering of extracellular ligand from receptor (GO:0035581)2.19935649
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.19691314
160blood vessel endothelial cell migration (GO:0043534)2.18872330
161bone trabecula formation (GO:0060346)2.17997973
162neuron projection extension involved in neuron projection guidance (GO:1902284)2.17994468
163axon extension involved in axon guidance (GO:0048846)2.17994468
164androgen biosynthetic process (GO:0006702)13.2086005
165regulation of gonadotropin secretion (GO:0032276)11.1534905
166estrogen metabolic process (GO:0008210)10.7717572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.73625072
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.19732155
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.97216150
4CLOCK_20551151_ChIP-Seq_293T_Human3.32184154
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76745931
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.74460612
7WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.55640047
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.54451985
9* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.37409844
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25960730
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.22230632
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20442696
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.13981020
14* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.12669473
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09956304
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09900650
17ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09276419
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02766977
19* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01921554
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01921554
21* TP53_20018659_ChIP-ChIP_R1E_Mouse2.00425093
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98416340
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96992271
24* NCOR1_26117541_ChIP-Seq_K562_Human1.96913747
25KDM2B_26808549_Chip-Seq_DND41_Human1.95653830
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.94159909
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.93239663
28* KDM2B_26808549_Chip-Seq_K562_Human1.86851858
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.86165810
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84669697
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.84246304
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.84010620
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79718717
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78207065
35* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77788065
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76783464
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73319757
38DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72383148
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71452242
40* LXR_22292898_ChIP-Seq_THP-1_Human1.68343260
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.67169828
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67040681
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.66109517
44* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65582055
45* KDM2B_26808549_Chip-Seq_JURKAT_Human1.65346687
46AR_21909140_ChIP-Seq_LNCAP_Human1.64198127
47* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63832953
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63425897
49* RING1B_27294783_Chip-Seq_NPCs_Mouse1.62548899
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62337046
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62325915
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62228443
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.52904855
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51585498
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.51394954
56RACK7_27058665_Chip-Seq_MCF-7_Human1.49777198
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48369926
58ATF3_27146783_Chip-Seq_COLON_Human1.47353345
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47130337
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46383989
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44377459
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43957935
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42476294
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40357624
65* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39355465
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38863282
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.37248753
68* EED_16625203_ChIP-ChIP_MESCs_Mouse1.36235956
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35105387
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34656619
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34656619
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34656619
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33589288
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33577897
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33403506
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32892544
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31217917
78* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31058622
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30856916
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30049311
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29859757
82GATA1_19941826_ChIP-Seq_K562_Human1.29828195
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29392341
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29041473
85* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28961696
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28102024
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.27639897
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27525076
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27450540
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26873078
91* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26320864
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.25888792
93* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25637844
94ZNF263_19887448_ChIP-Seq_K562_Human1.24498882
95* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24249372
96* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23979502
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.23353003
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23119532
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22331684
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22239379
101* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21706096
102* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17854517
103SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17735895
104TP53_16413492_ChIP-PET_HCT116_Human1.17335130
105NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16570053
106* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15573547
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.15020437
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14476615
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13873687
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13227799
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13021030
112ZNF274_21170338_ChIP-Seq_K562_Hela1.12731049
113* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12477597
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11946924
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11602043
116MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10933843
117* CREB1_26743006_Chip-Seq_LNCaP_Human1.10713600
118SA1_22415368_ChIP-Seq_MEFs_Mouse1.10636832
119* BRD4_25478319_ChIP-Seq_HGPS_Human1.09838597
120TP53_22127205_ChIP-Seq_IMR90_Human1.09617240
121MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09270259
122SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07270056
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06276552
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05520404
125SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04981125
126SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03467000
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03330943
128XRN2_22483619_ChIP-Seq_HELA_Human1.01746045
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01674712
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01674712
131* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01340394
132VDR_21846776_ChIP-Seq_THP-1_Human1.00273601
133TP53_23651856_ChIP-Seq_MEFs_Mouse1.00216609
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99933847
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98727462
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98394795
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98064320
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.96835112
139SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96689650
140MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96072664
141* EZH2_27294783_Chip-Seq_ESCs_Mouse0.95352808
142* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95009614
143TCF7_22412390_ChIP-Seq_EML_Mouse0.94016549
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93980967
145MYC_22102868_ChIP-Seq_BL_Human0.93863250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.73118773
2MP0001661_extended_life_span4.22268471
3MP0002909_abnormal_adrenal_gland3.85802162
4MP0000537_abnormal_urethra_morphology3.03906395
5MP0000678_abnormal_parathyroid_gland3.01850352
6MP0003315_abnormal_perineum_morphology2.99032260
7MP0005647_abnormal_sex_gland2.90621431
8MP0003283_abnormal_digestive_organ2.82351537
9MP0005187_abnormal_penis_morphology2.74094690
10MP0000639_abnormal_adrenal_gland2.59566240
11MP0004272_abnormal_basement_membrane2.52068507
12MP0005623_abnormal_meninges_morphology2.40966653
13MP0010368_abnormal_lymphatic_system2.34008913
14MP0009384_cardiac_valve_regurgitation2.33904887
15MP0003385_abnormal_body_wall2.22648608
16MP0003705_abnormal_hypodermis_morpholog2.22258913
17MP0001919_abnormal_reproductive_system2.17876625
18MP0009278_abnormal_bone_marrow2.16129167
19MP0005275_abnormal_skin_tensile2.10265221
20MP0001958_emphysema2.04198566
21MP0000013_abnormal_adipose_tissue2.02597091
22MP0010030_abnormal_orbit_morphology1.99811680
23MP0006054_spinal_hemorrhage1.92398007
24MP0005503_abnormal_tendon_morphology1.83160294
25MP0001849_ear_inflammation1.77728865
26MP0003195_calcinosis1.73075332
27MP0003115_abnormal_respiratory_system1.70675706
28MP0008995_early_reproductive_senescence1.67508366
29MP0003279_aneurysm1.59654642
30MP0005248_abnormal_Harderian_gland1.56468335
31MP0009250_abnormal_appendicular_skeleto1.55175808
32MP0002896_abnormal_bone_mineralization1.51519382
33MP0005389_reproductive_system_phenotype1.50567220
34MP0003122_maternal_imprinting1.46146136
35MP0005076_abnormal_cell_differentiation1.41324092
36MP0000566_synostosis1.39495080
37MP0010234_abnormal_vibrissa_follicle1.39014463
38MP0000462_abnormal_digestive_system1.38696856
39MP0009053_abnormal_anal_canal1.35841103
40MP0000049_abnormal_middle_ear1.34207998
41MP0002877_abnormal_melanocyte_morpholog1.33722296
42MP0005508_abnormal_skeleton_morphology1.33261219
43MP0003566_abnormal_cell_adhesion1.30952641
44MP0003786_premature_aging1.30307747
45MP0000733_abnormal_muscle_development1.28401098
46MP0000767_abnormal_smooth_muscle1.25643149
47MP0003935_abnormal_craniofacial_develop1.24945856
48MP0004858_abnormal_nervous_system1.24437298
49MP0000428_abnormal_craniofacial_morphol1.24056099
50MP0003123_paternal_imprinting1.23404520
51MP0003937_abnormal_limbs/digits/tail_de1.23107093
52MP0002282_abnormal_trachea_morphology1.21600320
53MP0002092_abnormal_eye_morphology1.20020932
54* MP0001340_abnormal_eyelid_morphology1.19883447
55MP0000751_myopathy1.19620648
56MP0002009_preneoplasia1.19020046
57MP0003942_abnormal_urinary_system1.18615958
58MP0003119_abnormal_digestive_system1.17529036
59MP0003755_abnormal_palate_morphology1.17423868
60MP0003567_abnormal_fetal_cardiomyocyte1.17331175
61MP0000467_abnormal_esophagus_morphology1.16648284
62MP0004883_abnormal_blood_vessel1.16145288
63MP0009780_abnormal_chondrocyte_physiolo1.13567663
64MP0000534_abnormal_ureter_morphology1.10293395
65MP0002932_abnormal_joint_morphology1.09910985
66MP0002108_abnormal_muscle_morphology1.09327468
67MP0001881_abnormal_mammary_gland1.08385906
68MP0000003_abnormal_adipose_tissue1.08352915
69MP0001346_abnormal_lacrimal_gland1.06997675
70MP0000762_abnormal_tongue_morphology1.06106265
71MP0001348_abnormal_lacrimal_gland1.05926418
72MP0008007_abnormal_cellular_replicative1.05089316
73MP0003091_abnormal_cell_migration1.04846817
74MP0006138_congestive_heart_failure1.03099701
75MP0002114_abnormal_axial_skeleton1.02431815
76MP0004957_abnormal_blastocyst_morpholog1.01651222
77MP0002115_abnormal_skeleton_extremities1.00835422
78MP0001730_embryonic_growth_arrest1.00170136
79MP0002249_abnormal_larynx_morphology0.99963298
80MP0004145_abnormal_muscle_electrophysio0.99700775
81MP0003936_abnormal_reproductive_system0.99656496
82MP0000579_abnormal_nail_morphology0.99114517
83MP0003941_abnormal_skin_development0.99086609
84MP0000470_abnormal_stomach_morphology0.98661832
85MP0002233_abnormal_nose_morphology0.96225688
86MP0004134_abnormal_chest_morphology0.95653979
87MP0004197_abnormal_fetal_growth/weight/0.92992431
88MP0008004_abnormal_stomach_pH0.92929550
89MP0001879_abnormal_lymphatic_vessel0.92273369
90MP0010386_abnormal_urinary_bladder0.91538713
91MP0002116_abnormal_craniofacial_bone0.90920362
92MP0002168_other_aberrant_phenotype0.90412098
93MP0005257_abnormal_intraocular_pressure0.89841009
94MP0004185_abnormal_adipocyte_glucose0.89091579
95MP0000163_abnormal_cartilage_morphology0.88799841
96MP0003111_abnormal_nucleus_morphology0.87118136
97MP0005023_abnormal_wound_healing0.86076767
98MP0002084_abnormal_developmental_patter0.85575929
99MP0000538_abnormal_urinary_bladder0.85544719
100MP0008932_abnormal_embryonic_tissue0.84954053
101MP0001243_abnormal_dermal_layer0.84803337
102MP0005409_darkened_coat_color0.84533664
103MP0003693_abnormal_embryo_hatching0.84431281
104MP0001697_abnormal_embryo_size0.83990742
105MP0000432_abnormal_head_morphology0.83956143
106MP0004264_abnormal_extraembryonic_tissu0.83793270
107MP0004233_abnormal_muscle_weight0.83782272
108MP0001915_intracranial_hemorrhage0.83620094
109MP0002697_abnormal_eye_size0.83160553
110MP0002089_abnormal_postnatal_growth/wei0.82667954
111MP0003950_abnormal_plasma_membrane0.82631234
112MP0005390_skeleton_phenotype0.81840899
113MP0002128_abnormal_blood_circulation0.81513355
114MP0001299_abnormal_eye_distance/0.80788837
115MP0001542_abnormal_bone_strength0.80643536
116MP0000631_abnormal_neuroendocrine_gland0.79717211
117MP0002111_abnormal_tail_morphology0.78232093
118MP0000627_abnormal_mammary_gland0.78212035
119MP0002060_abnormal_skin_morphology0.77945576
120MP0002925_abnormal_cardiovascular_devel0.77715425
121MP0002254_reproductive_system_inflammat0.77008546
122MP0002109_abnormal_limb_morphology0.76666511
123MP0002113_abnormal_skeleton_development0.76160075
124MP0002269_muscular_atrophy0.74690647
125MP0003453_abnormal_keratinocyte_physiol0.74552330
126* MP0001119_abnormal_female_reproductive0.74221051
127* MP0003699_abnormal_female_reproductive0.72572744
128MP0002295_abnormal_pulmonary_circulatio0.71130439
129MP0009379_abnormal_foot_pigmentation0.70715911
130MP0005164_abnormal_response_to0.70523970
131MP0002085_abnormal_embryonic_tissue0.69545265
132MP0002160_abnormal_reproductive_system0.68687157
133MP0002086_abnormal_extraembryonic_tissu0.68511241
134MP0010352_gastrointestinal_tract_polyps0.68216665
135MP0002080_prenatal_lethality0.68195766
136MP0003984_embryonic_growth_retardation0.67845899
137MP0005501_abnormal_skin_physiology0.67428995
138MP0005197_abnormal_uvea_morphology0.66478132

Predicted human phenotypes

RankGene SetZ-score
1* Gonadotropin excess (HP:0000837)7.57426746
2Sex reversal (HP:0012245)6.97796140
3Abnormal sex determination (HP:0012244)6.97796140
4Enlarged penis (HP:0000040)5.54047803
5Abnormality of the 1st metacarpal (HP:0010009)4.58099805
6Abnormality of the proximal phalanges of the hand (HP:0009834)4.47239450
7Protrusio acetabuli (HP:0003179)4.41910869
8Relative macrocephaly (HP:0004482)4.41444544
9Premature rupture of membranes (HP:0001788)4.34003942
10Abnormality of the phalanges of the hallux (HP:0010057)4.31186562
11Macroorchidism (HP:0000053)4.21834116
12Shallow orbits (HP:0000586)4.10841700
13Cerebral aneurysm (HP:0004944)3.97419604
14* Hyperpituitarism (HP:0010514)3.88717976
15Renal salt wasting (HP:0000127)3.82707390
16Testicular neoplasm (HP:0010788)3.76954541
17Abnormality of the middle phalanges of the toes (HP:0010183)3.69928639
18Ankle contracture (HP:0006466)3.62951719
19Broad metatarsal (HP:0001783)3.59996918
20Gonadal dysgenesis (HP:0000133)3.58715828
21Cupped ribs (HP:0000887)3.51074127
22Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.39202781
23Short humerus (HP:0005792)3.29788099
24Short phalanx of the thumb (HP:0009660)3.22205943
25Lymphangioma (HP:0100764)3.13453349
26Abnormality of the distal phalanx of the thumb (HP:0009617)3.07336055
27Flared iliac wings (HP:0002869)2.99703007
28Abnormality of carpal bone ossification (HP:0006257)2.99411225
29Aortic dissection (HP:0002647)2.93757467
30Aplasia/hypoplasia of the humerus (HP:0006507)2.90650383
31Buphthalmos (HP:0000557)2.84070241
32Aortic aneurysm (HP:0004942)2.82883919
33Short tibia (HP:0005736)2.81888310
34Coxa vara (HP:0002812)2.72834763
35Absent phalangeal crease (HP:0006109)2.71394310
36Ulnar bowing (HP:0003031)2.70055613
37Turricephaly (HP:0000262)2.68036442
38Short hallux (HP:0010109)2.64480586
39Hyperaldosteronism (HP:0000859)2.58746877
40Abnormal ossification of hand bones (HP:0005921)2.56589323
41Symphalangism affecting the phalanges of the hand (HP:0009773)2.52033580
42Multiple enchondromatosis (HP:0005701)2.51638046
43Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.49158506
44Asymmetry of the thorax (HP:0001555)2.48478947
45Short 4th metacarpal (HP:0010044)2.46319994
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46319994
47Aplasia/Hypoplasia of the hallux (HP:0008362)2.44914494
48Coronal craniosynostosis (HP:0004440)2.43619607
49Aplasia involving bones of the extremities (HP:0009825)2.35129912
50Aplasia involving bones of the upper limbs (HP:0009823)2.35129912
51Aplasia of the phalanges of the hand (HP:0009802)2.35129912
52Rectal prolapse (HP:0002035)2.34980111
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.33813319
54Broad palm (HP:0001169)2.30804001
55Lumbar hyperlordosis (HP:0002938)2.30437781
56Hypoplasia of the uterus (HP:0000013)2.29667364
57Selective tooth agenesis (HP:0001592)2.29005959
58Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.28621710
59Blue sclerae (HP:0000592)2.25634794
60Mitral valve prolapse (HP:0001634)2.22762323
61Bladder diverticulum (HP:0000015)2.21699372
62Abnormality of the 4th metacarpal (HP:0010012)2.20130103
63Premature skin wrinkling (HP:0100678)2.19475382
64Ovoid vertebral bodies (HP:0003300)2.19204748
65Wormian bones (HP:0002645)2.18724950
66Abnormal finger flexion creases (HP:0006143)2.17550857
67Exostoses (HP:0100777)2.16909602
68Trismus (HP:0000211)2.14920708
69Ankyloglossia (HP:0010296)2.14738352
70Aneurysm (HP:0002617)2.13624250
71Abnormal hand bone ossification (HP:0010660)2.12234846
72Abnormality of dentin (HP:0010299)2.10543993
73Abnormality of the 2nd finger (HP:0004100)2.08861572
74Arachnodactyly (HP:0001166)2.08507581
75Bowing of the arm (HP:0006488)2.07107028
76Bowed forearm bones (HP:0003956)2.07107028
77Neonatal short-limb short stature (HP:0008921)2.04571285
78Hallux valgus (HP:0001822)2.03287087
79Short femoral neck (HP:0100864)2.01876000
80Fragile skin (HP:0001030)2.01590594
81Deviation of the hallux (HP:0010051)2.00759788
82Arterial tortuosity (HP:0005116)2.00089770
83Abnormality of the epiphyses of the hand (HP:0005924)1.99420288
84Atelectasis (HP:0100750)1.98668141
85Congenital glaucoma (HP:0001087)1.98487652
86Wide anterior fontanel (HP:0000260)1.97672873
87Increased connective tissue (HP:0009025)1.97375279
88Abnormal hemoglobin (HP:0011902)1.96589081
89Abnormality of oral frenula (HP:0000190)1.95994198
90Spinal rigidity (HP:0003306)1.93605597
91Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.92917730
92Breech presentation (HP:0001623)1.92766021
93Absent frontal sinuses (HP:0002688)1.92227845
94Mesomelia (HP:0003027)1.91616911
95Vascular tortuosity (HP:0004948)1.90314338
96Dilatation of the ascending aorta (HP:0005111)1.90020249
97Abnormality of the acetabulum (HP:0003170)1.88565978
98Wrist flexion contracture (HP:0001239)1.88438469
99Soft skin (HP:0000977)1.87498697
100Vertebral compression fractures (HP:0002953)1.86977116
101Sparse lateral eyebrow (HP:0005338)1.86931397
102Overgrowth (HP:0001548)1.86677861
103Atrophic scars (HP:0001075)1.85417718
104Hypoplastic iliac wings (HP:0002866)1.85236316
105Persistence of primary teeth (HP:0006335)1.85021334
106Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.84860621
107Short middle phalanx of finger (HP:0005819)1.84333618
108Thin bony cortex (HP:0002753)1.83901599
109Abnormality of the parietal bone (HP:0002696)1.83884879
110Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.83789475
111Radial bowing (HP:0002986)1.81715248
112Biconcave vertebral bodies (HP:0004586)1.80996273
113Adrenal overactivity (HP:0002717)1.80251737
114Short nail (HP:0001799)1.79778780
115Abnormal cartilage morphology (HP:0002763)1.79533632
116Synostosis involving bones of the hand (HP:0004278)1.79215806
117Cervical subluxation (HP:0003308)1.78486698
118Osteomalacia (HP:0002749)1.78193037
119Follicular hyperkeratosis (HP:0007502)1.77435126
120Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76862024
121Visceral angiomatosis (HP:0100761)1.76833870
122Venous abnormality (HP:0002624)1.75550249
123Abnormality of the humerus (HP:0003063)1.75456047
124Protruding ear (HP:0000411)1.75075209
125Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.75074488
126Abnormality of femoral epiphyses (HP:0006499)1.75074488
127Broad ribs (HP:0000885)1.73850014
128Spondylolisthesis (HP:0003302)1.73815219
129Deviation of the thumb (HP:0009603)1.73510722
130Narrow nasal bridge (HP:0000446)1.73074712
131Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72631694
132Ectopia lentis (HP:0001083)1.72131868
133Breast hypoplasia (HP:0003187)1.72127213
134Hyperacusis (HP:0010780)1.71376824
135Type 1 muscle fiber predominance (HP:0003803)1.70832754
136Pseudobulbar signs (HP:0002200)1.70368340
137Mitral regurgitation (HP:0001653)1.70138946
138Delayed closure of the anterior fontanelle (HP:0001476)1.69723966
139Secondary amenorrhea (HP:0000869)1.69522810
140Broad toe (HP:0001837)1.68981089
141Elbow flexion contracture (HP:0002987)1.68513289
142Back pain (HP:0003418)1.65976738
143Narrow palate (HP:0000189)1.65452774
144Broad alveolar ridges (HP:0000187)1.65401298
145Peritonitis (HP:0002586)1.64376318
146Joint laxity (HP:0001388)1.63813406
147Hemangiomatosis (HP:0007461)1.63259808
148Broad hallux (HP:0010055)1.63001552
149Long toe (HP:0010511)1.62707696
150Hyperextensible skin (HP:0000974)1.62384672
151Increased variability in muscle fiber diameter (HP:0003557)1.62264576
152Genu recurvatum (HP:0002816)1.61678284
153Absent toe (HP:0010760)1.61356389
154Renal duplication (HP:0000075)1.60749863
155Pointed chin (HP:0000307)1.60723384
156Male infertility (HP:0003251)1.59905042
157Inguinal hernia (HP:0000023)1.59759815
158Hematochezia (HP:0002573)1.59283807
159Disproportionate tall stature (HP:0001519)1.58956663
160Broad long bones (HP:0005622)1.58821183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.99498837
2DDR23.56004937
3PDGFRA3.32333632
4TAOK23.24007508
5PDK23.09562392
6ICK3.09485015
7PIK3CG3.08481470
8MST1R2.88442697
9TSSK62.68135003
10RIPK12.62694282
11TTN2.57778990
12LATS22.21101063
13EPHB22.20456533
14PTK62.11991849
15PKN22.05328111
16SMG11.87513569
17FER1.80522031
18LRRK21.78863054
19TYRO31.77012983
20TGFBR21.71809493
21LATS11.71573903
22EEF2K1.69117985
23CDK71.66506883
24EPHA21.61192674
25KSR21.60652015
26PAK21.58932796
27CLK11.57136413
28CDK81.56830016
29MAP3K101.53931707
30PAK31.44505208
31CDK91.39799188
32TTK1.37587109
33CDK121.33227606
34DMPK1.29689783
35PRKD31.29266487
36TIE11.27317675
37PAK41.25762404
38FGFR21.25636250
39UHMK11.25006779
40PTK21.20536413
41NEK21.19445440
42MYLK1.15029335
43LMTK21.14879341
44MTOR1.12579795
45NEK91.11926636
46PAK61.10471400
47NME21.08676041
48ILK1.08520302
49IRAK31.06321506
50BMX1.06149678
51PDGFRB1.04417263
52MELK1.03422690
53STK381.01564501
54DYRK1B1.01284547
55KSR11.00851464
56CDK60.98472733
57PTK2B0.97358274
58CSNK1G10.95172356
59WEE10.94309239
60ALK0.94080564
61FGR0.93394673
62NTRK10.92275376
63SIK10.91647785
64MAP3K90.88806536
65ERN10.88313691
66KDR0.85436785
67MET0.85432360
68BRD40.84604001
69TAOK10.84117520
70FGFR10.82639821
71RPS6KB20.82098033
72MAP3K80.80351140
73MAP3K70.80277119
74MAP3K60.79894087
75STK160.77316581
76SCYL20.75965536
77GSK3A0.72870250
78STK30.72619592
79ROCK20.71914769
80TGFBR10.71708826
81BUB10.71581943
82EIF2AK10.68560071
83NME10.68288464
84PRPF4B0.67764245
85CDC42BPA0.64674953
86LIMK10.63537378
87CDC70.63242824
88CAMKK10.62823890
89TNK20.62403419
90ERBB40.61520648
91AKT30.60805101
92NTRK30.58986295
93SIK20.58981128
94CDK40.58331471
95MOS0.57913628
96MAPKAPK30.57571102
97DAPK20.57427486
98PNCK0.57167734
99CSNK1A1L0.56972054
100RPS6KL10.56135231
101RPS6KC10.56135231
102PRKG20.55429612
103* PAK10.55251768
104ERBB30.54263572
105CHEK10.53593492
106MUSK0.52179345
107RPS6KA10.52050971
108RET0.51214474
109CAMK1G0.50016574
110ERBB20.49870655
111SRC0.49765054
112MAP2K20.48833407
113PRKD20.48606329
114MAPK150.47238993
115MAPK10.46703680
116CDK150.46690651
117MAPK70.46528266
118CDK140.46006434
119MAP2K10.45414717
120CHEK20.44992976
121CDK11A0.44930825
122TESK10.44402687
123MAPK30.44387975
124PRKCH0.44325003
125MATK0.43282889
126NEK60.42910376
127CSNK1G30.41688124
128ROCK10.41640087
129RAF10.41288695
130CAMK1D0.40167152
131DAPK30.40106901
132RPS6KA60.40021707
133CSNK1E0.39698106
134CDK180.39230118
135PRKD10.39098147
136MAPKAPK50.37701812
137MAP3K20.37408515
138INSR0.37280320
139AURKB0.37122976
140CDK10.36861548
141RPS6KA20.36854969
142TRPM70.36410514
143EPHB10.34993619
144CDK30.32500667
145NEK10.32288721
146RPS6KA50.30780255
147WNK10.29156938
148AURKA0.28961862

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049137.64971187
2Steroid hormone biosynthesis_Homo sapiens_hsa001405.52067280
3Aldosterone synthesis and secretion_Homo sapiens_hsa049253.13921020
4TGF-beta signaling pathway_Homo sapiens_hsa043502.14845785
5Hedgehog signaling pathway_Homo sapiens_hsa043401.96789986
6Basal cell carcinoma_Homo sapiens_hsa052171.88468972
7ECM-receptor interaction_Homo sapiens_hsa045121.81659889
8Fatty acid biosynthesis_Homo sapiens_hsa000611.80124181
9Hippo signaling pathway_Homo sapiens_hsa043901.69518907
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68601010
11Focal adhesion_Homo sapiens_hsa045101.61553961
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57971766
13Proteoglycans in cancer_Homo sapiens_hsa052051.56281473
14Steroid biosynthesis_Homo sapiens_hsa001001.53222062
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47732070
16One carbon pool by folate_Homo sapiens_hsa006701.43520386
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41347416
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39969817
19Estrogen signaling pathway_Homo sapiens_hsa049151.38461770
20Thyroid cancer_Homo sapiens_hsa052161.33775637
21DNA replication_Homo sapiens_hsa030301.26442906
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25421371
23Adherens junction_Homo sapiens_hsa045201.24993453
24Cell cycle_Homo sapiens_hsa041101.22443445
25N-Glycan biosynthesis_Homo sapiens_hsa005101.18206251
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13279361
27Wnt signaling pathway_Homo sapiens_hsa043101.12585256
28Axon guidance_Homo sapiens_hsa043601.12097538
29Prolactin signaling pathway_Homo sapiens_hsa049171.09566339
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09417607
31Amoebiasis_Homo sapiens_hsa051461.08952427
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06613588
33Chronic myeloid leukemia_Homo sapiens_hsa052201.06220617
34Melanogenesis_Homo sapiens_hsa049161.04267779
35Nucleotide excision repair_Homo sapiens_hsa034201.04043031
36mTOR signaling pathway_Homo sapiens_hsa041501.02411683
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00148963
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99295017
39Spliceosome_Homo sapiens_hsa030400.98817659
40Galactose metabolism_Homo sapiens_hsa000520.97713692
41MicroRNAs in cancer_Homo sapiens_hsa052060.96046290
42RNA transport_Homo sapiens_hsa030130.95970483
43Gap junction_Homo sapiens_hsa045400.95661424
44Biosynthesis of amino acids_Homo sapiens_hsa012300.94777478
45Small cell lung cancer_Homo sapiens_hsa052220.93608951
46Notch signaling pathway_Homo sapiens_hsa043300.92309227
47Glioma_Homo sapiens_hsa052140.91870652
48Lysine degradation_Homo sapiens_hsa003100.90911929
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86198337
50Colorectal cancer_Homo sapiens_hsa052100.84678635
51Fatty acid metabolism_Homo sapiens_hsa012120.83604806
52Arginine biosynthesis_Homo sapiens_hsa002200.83444896
53Pentose phosphate pathway_Homo sapiens_hsa000300.82948224
54Dilated cardiomyopathy_Homo sapiens_hsa054140.82798425
55Tight junction_Homo sapiens_hsa045300.82512225
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82235486
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81521354
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76807322
59Oxytocin signaling pathway_Homo sapiens_hsa049210.76550600
60mRNA surveillance pathway_Homo sapiens_hsa030150.75826267
61Pyruvate metabolism_Homo sapiens_hsa006200.75339801
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.75230385
63VEGF signaling pathway_Homo sapiens_hsa043700.72762657
64Bladder cancer_Homo sapiens_hsa052190.72146214
65Mismatch repair_Homo sapiens_hsa034300.72137580
66GnRH signaling pathway_Homo sapiens_hsa049120.70823402
67Prostate cancer_Homo sapiens_hsa052150.66713042
68Pathways in cancer_Homo sapiens_hsa052000.66081564
69Endometrial cancer_Homo sapiens_hsa052130.66062001
70Protein digestion and absorption_Homo sapiens_hsa049740.66053038
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64768044
72p53 signaling pathway_Homo sapiens_hsa041150.63921049
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63385286
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62387578
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.62347102
76Gastric acid secretion_Homo sapiens_hsa049710.62176623
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61430107
78Pancreatic cancer_Homo sapiens_hsa052120.60280852
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.59982108
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59651734
81Hepatitis B_Homo sapiens_hsa051610.58942633
82Rap1 signaling pathway_Homo sapiens_hsa040150.58794277
83Thyroid hormone synthesis_Homo sapiens_hsa049180.58619711
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.58588125
85Renal cell carcinoma_Homo sapiens_hsa052110.57450283
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56801019
87Prion diseases_Homo sapiens_hsa050200.56642371
88Bile secretion_Homo sapiens_hsa049760.56220601
89ErbB signaling pathway_Homo sapiens_hsa040120.56182897
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55873852
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.55129519
92Oocyte meiosis_Homo sapiens_hsa041140.55048743
93Renin secretion_Homo sapiens_hsa049240.54514969
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53204749
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52164029
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50938653
97Dorso-ventral axis formation_Homo sapiens_hsa043200.50336468
98Choline metabolism in cancer_Homo sapiens_hsa052310.50139175
99cAMP signaling pathway_Homo sapiens_hsa040240.49253526
100Long-term potentiation_Homo sapiens_hsa047200.49192355
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.48384976
102Platelet activation_Homo sapiens_hsa046110.48206011
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48083365
104Fanconi anemia pathway_Homo sapiens_hsa034600.47816751
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47534545
106Carbon metabolism_Homo sapiens_hsa012000.46975662
107Nitrogen metabolism_Homo sapiens_hsa009100.46849319
108Basal transcription factors_Homo sapiens_hsa030220.46312975
109Dopaminergic synapse_Homo sapiens_hsa047280.45876704
110Inositol phosphate metabolism_Homo sapiens_hsa005620.45329928
111Sulfur relay system_Homo sapiens_hsa041220.45258472
112Insulin resistance_Homo sapiens_hsa049310.44720163
113HTLV-I infection_Homo sapiens_hsa051660.44110580
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43792062
115Fructose and mannose metabolism_Homo sapiens_hsa000510.43383558
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42264617
117Insulin signaling pathway_Homo sapiens_hsa049100.42193580
118Cocaine addiction_Homo sapiens_hsa050300.42118844
119Non-small cell lung cancer_Homo sapiens_hsa052230.41939105
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41828839
121Other glycan degradation_Homo sapiens_hsa005110.41771471
122AMPK signaling pathway_Homo sapiens_hsa041520.40622553
123Acute myeloid leukemia_Homo sapiens_hsa052210.39997288
124PPAR signaling pathway_Homo sapiens_hsa033200.39882366
125Vitamin digestion and absorption_Homo sapiens_hsa049770.39652078
126Melanoma_Homo sapiens_hsa052180.38647840
127MAPK signaling pathway_Homo sapiens_hsa040100.38595457
128Viral myocarditis_Homo sapiens_hsa054160.37607688
129Fatty acid degradation_Homo sapiens_hsa000710.37299619
130Cholinergic synapse_Homo sapiens_hsa047250.36340091
131Circadian entrainment_Homo sapiens_hsa047130.36072753
132Amphetamine addiction_Homo sapiens_hsa050310.35453706
133Long-term depression_Homo sapiens_hsa047300.35025503
134Calcium signaling pathway_Homo sapiens_hsa040200.34700932
135Type II diabetes mellitus_Homo sapiens_hsa049300.32774469
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32675414

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