FOXN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.95111495
2virion attachment to host cell (GO:0019062)9.51874432
3adhesion of symbiont to host cell (GO:0044650)9.51874432
4keratinocyte proliferation (GO:0043616)9.34930790
5bundle of His cell to Purkinje myocyte communication (GO:0086069)9.00106728
6water homeostasis (GO:0030104)8.54005685
7* epidermal cell differentiation (GO:0009913)7.85055572
8adhesion of symbiont to host (GO:0044406)7.59512991
9hemidesmosome assembly (GO:0031581)7.18061324
10collecting duct development (GO:0072044)6.91494966
11negative regulation of activin receptor signaling pathway (GO:0032926)6.63307543
12molting cycle (GO:0042303)6.58006633
13hair cycle (GO:0042633)6.58006633
14long-chain fatty acid biosynthetic process (GO:0042759)6.49127591
15detection of bacterium (GO:0016045)6.32955945
16linoleic acid metabolic process (GO:0043651)6.08755072
17lipoxygenase pathway (GO:0019372)6.06275367
18cellular response to interferon-alpha (GO:0035457)5.76338467
19detection of other organism (GO:0098543)5.66679791
20positive regulation of natural killer cell differentiation (GO:0032825)5.59654274
21regulation of dendritic cell antigen processing and presentation (GO:0002604)5.53074459
22antigen processing and presentation of endogenous antigen (GO:0019883)5.41579790
23epithelial cell differentiation involved in prostate gland development (GO:0060742)5.36459548
24intermediate filament organization (GO:0045109)5.24134054
25phosphatidylserine acyl-chain remodeling (GO:0036150)5.19505524
26phosphatidylinositol acyl-chain remodeling (GO:0036149)4.85763735
27regulation of glomerular filtration (GO:0003093)4.80920679
28positive regulation of antigen processing and presentation (GO:0002579)4.75186771
29regulation of natural killer cell differentiation (GO:0032823)4.73501112
30regulation of secondary heart field cardioblast proliferation (GO:0003266)4.70103378
31regulation of cardioblast proliferation (GO:0003264)4.70103378
32skin morphogenesis (GO:0043589)4.69925819
33polarized epithelial cell differentiation (GO:0030859)4.51770334
34negative regulation of interferon-gamma production (GO:0032689)4.34245985
35negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.23442138
36cellular response to vitamin (GO:0071295)4.22063761
37hair follicle morphogenesis (GO:0031069)4.20752276
38ectoderm development (GO:0007398)4.10491472
39regulation of transforming growth factor beta2 production (GO:0032909)4.08678926
40phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.06092352
41positive regulation of epidermal cell differentiation (GO:0045606)3.99037690
42regulation of keratinocyte differentiation (GO:0045616)3.93442948
43renal system process involved in regulation of blood volume (GO:0001977)3.93215350
44regulation of antigen processing and presentation (GO:0002577)3.92498419
45skin development (GO:0043588)3.90228122
46fatty acid elongation (GO:0030497)3.88526786
47epithelial cell fate commitment (GO:0072148)3.87830751
48negative regulation of keratinocyte proliferation (GO:0010839)3.84662565
49phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.83217259
50regulation of hair follicle development (GO:0051797)3.79747030
51keratinization (GO:0031424)3.77340690
52gap junction assembly (GO:0016264)3.77048561
53* thymus development (GO:0048538)3.71575734
54positive regulation of keratinocyte differentiation (GO:0045618)3.71508985
55atrioventricular valve morphogenesis (GO:0003181)3.66808294
56surfactant homeostasis (GO:0043129)3.65876516
57mitotic G1 DNA damage checkpoint (GO:0031571)3.57863658
58phosphatidylcholine acyl-chain remodeling (GO:0036151)3.55052223
59proline transport (GO:0015824)3.54083413
60positive regulation of epidermis development (GO:0045684)3.51934307
61negative regulation of leukocyte apoptotic process (GO:2000107)3.51175798
62regulation of somitogenesis (GO:0014807)3.50049186
63* keratinocyte differentiation (GO:0030216)3.49892002
64regulation of water loss via skin (GO:0033561)3.48401776
65ventricular cardiac muscle cell action potential (GO:0086005)3.44122261
66mesenchymal cell differentiation involved in renal system development (GO:2001012)3.42638297
67mesenchymal cell differentiation involved in kidney development (GO:0072161)3.42638297
68bone morphogenesis (GO:0060349)3.42567574
69* epithelium development (GO:0060429)3.39959974
70regulation of interleukin-1 secretion (GO:0050704)3.29537665
71* epidermis development (GO:0008544)3.27349551
72ganglion development (GO:0061548)3.27248896
73response to interferon-alpha (GO:0035455)3.24884921
74regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)3.24452282
75G1 DNA damage checkpoint (GO:0044783)3.23947754
76oxygen transport (GO:0015671)3.23919878
77extracellular matrix assembly (GO:0085029)3.21440818
78gland morphogenesis (GO:0022612)3.20796780
79mitotic G1/S transition checkpoint (GO:0044819)3.20048750
80CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.19501110
81phosphatidylserine metabolic process (GO:0006658)3.18520468
82positive regulation of Cdc42 GTPase activity (GO:0043089)3.16954991
83aorta morphogenesis (GO:0035909)3.16857236
84pharyngeal system development (GO:0060037)3.16710409
85negative regulation of fibroblast apoptotic process (GO:2000270)3.15849054
86peptide cross-linking (GO:0018149)3.14446750
87thymic T cell selection (GO:0045061)3.14336618
88establishment of skin barrier (GO:0061436)3.13359108
89negative regulation of T cell apoptotic process (GO:0070233)3.13123398
90intermediate filament cytoskeleton organization (GO:0045104)3.11515231
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11471513
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.11471513
93regulation of keratinocyte proliferation (GO:0010837)3.09364950
94regulation of heart rate by cardiac conduction (GO:0086091)3.09294275
95positive regulation of embryonic development (GO:0040019)3.06712660
96epithelial cell-cell adhesion (GO:0090136)3.06640917
97positive regulation of granulocyte chemotaxis (GO:0071624)3.03068979
98detection of external biotic stimulus (GO:0098581)3.02979682
99regulation of epidermal cell differentiation (GO:0045604)3.01379117
100intermediate filament-based process (GO:0045103)3.01298756
101regulation of endothelial cell chemotaxis (GO:2001026)3.00725785
102cytokine production involved in immune response (GO:0002367)3.00448693
103epithelial cell morphogenesis (GO:0003382)2.98957294
104negative regulation of biomineral tissue development (GO:0070168)2.97393527
105dendritic cell differentiation (GO:0097028)2.95114324
106ceramide biosynthetic process (GO:0046513)2.93700140
107myoblast migration (GO:0051451)2.93699922
108chemical homeostasis within a tissue (GO:0048875)2.91990085
109renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.91834433
110regulation of epidermis development (GO:0045682)2.91744981
111imidazole-containing compound metabolic process (GO:0052803)2.90803632
112negative regulation of cell fate specification (GO:0009996)2.89027065
113establishment of tissue polarity (GO:0007164)2.87101726
114establishment of planar polarity (GO:0001736)2.87101726
115cell communication involved in cardiac conduction (GO:0086065)2.85292019
116regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.85021808
117eyelid development in camera-type eye (GO:0061029)2.84734282
118regulation of hair cycle (GO:0042634)2.81453849
119CD4-positive, alpha-beta T cell activation (GO:0035710)2.79841598
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76000053
121peptidyl-glutamic acid carboxylation (GO:0017187)2.74165536
122protein carboxylation (GO:0018214)2.74165536
123positive regulation of protein export from nucleus (GO:0046827)2.73933031
124regulation of protein import into nucleus, translocation (GO:0033158)2.73846790
125regulation of T-helper 1 cell differentiation (GO:0045625)2.73234423
126cell-substrate junction assembly (GO:0007044)2.73019126
127multicellular organismal water homeostasis (GO:0050891)2.71735344
128phospholipid catabolic process (GO:0009395)2.71446588
129regulation of phospholipase A2 activity (GO:0032429)2.71030123
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69681739
131alditol phosphate metabolic process (GO:0052646)2.65911418
132lateral sprouting from an epithelium (GO:0060601)2.65551614
133positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.65398240
134keratinocyte development (GO:0003334)2.62905089
135positive regulation of monocyte chemotaxis (GO:0090026)2.62900086
136non-canonical Wnt signaling pathway (GO:0035567)2.60251454
137morphogenesis of embryonic epithelium (GO:0016331)2.60158230
138positive regulation of hormone biosynthetic process (GO:0046886)2.58857148
139NIK/NF-kappaB signaling (GO:0038061)2.58543016
140glycine transport (GO:0015816)2.57444269
141lung lobe morphogenesis (GO:0060463)2.56322974
142detection of biotic stimulus (GO:0009595)2.55034353
143* molting cycle process (GO:0022404)2.54978184
144* hair cycle process (GO:0022405)2.54978184
145positive regulation of cholesterol efflux (GO:0010875)2.54725275
146DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54105623
147prostaglandin biosynthetic process (GO:0001516)2.53973632
148prostanoid biosynthetic process (GO:0046457)2.53973632
149regulation of Cdc42 GTPase activity (GO:0043088)2.53872756
150negative regulation of lymphocyte apoptotic process (GO:0070229)2.53653027
151Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.51640082
152retinoic acid receptor signaling pathway (GO:0048384)2.48983984
153intestinal epithelial cell development (GO:0060576)2.48385414
154regulation of ruffle assembly (GO:1900027)2.46375072
155primary alcohol catabolic process (GO:0034310)2.44697424
156negative regulation of epidermis development (GO:0045683)2.44503587
157unsaturated fatty acid biosynthetic process (GO:0006636)2.41549635
158cellular response to antibiotic (GO:0071236)2.40716718
159regulation of natural killer cell activation (GO:0032814)2.40229777
160regulation of establishment of planar polarity (GO:0090175)2.38636193
161cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.38268913
162response to phenylpropanoid (GO:0080184)2.37602864
163negative regulation of epidermal cell differentiation (GO:0045605)2.37549599
164regulation of cardioblast differentiation (GO:0051890)2.35567170
165positive regulation of cholesterol transport (GO:0032376)2.27291358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.91386009
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.53533596
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.20988347
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32399090
5ZNF263_19887448_ChIP-Seq_K562_Human2.29635201
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22185433
7SOX9_24532713_ChIP-Seq_HFSC_Mouse2.19518906
8* RACK7_27058665_Chip-Seq_MCF-7_Human2.10886437
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.08329656
10LXR_22292898_ChIP-Seq_THP-1_Human2.05865770
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.02696842
12EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97201606
13RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97201606
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.93351278
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89912498
16RNF2_27304074_Chip-Seq_ESCs_Mouse1.89855105
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86753806
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85633296
19P63_26484246_Chip-Seq_KERATINOCYTES_Human1.84606618
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81731726
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76274487
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76032077
23* SMC4_20622854_ChIP-Seq_HELA_Human1.73911739
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73663564
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.72599485
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71770644
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71221080
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70159726
29AR_21572438_ChIP-Seq_LNCaP_Human1.67536675
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66199886
31* TP53_20018659_ChIP-ChIP_R1E_Mouse1.64515004
32P68_20966046_ChIP-Seq_HELA_Human1.60931318
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.60026169
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59952219
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58978408
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56381708
37* BCOR_27268052_Chip-Seq_Bcells_Human1.54965330
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52725902
39GBX2_23144817_ChIP-Seq_PC3_Human1.52338192
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.51509240
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51279482
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48753080
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.48683881
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47739586
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.45676020
46E2F1_20622854_ChIP-Seq_HELA_Human1.45220266
47ATF3_27146783_Chip-Seq_COLON_Human1.45138369
48AHR_22903824_ChIP-Seq_MCF-7_Human1.44814390
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.44098065
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.42136568
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41998404
52SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41071944
53EZH2_22144423_ChIP-Seq_EOC_Human1.39861009
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38078227
55TP53_18474530_ChIP-ChIP_U2OS_Human1.37923774
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36644951
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.35921104
58* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35505337
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.35479634
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31236173
61* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30416960
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30386280
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29916490
64CTCF_20526341_ChIP-Seq_ESCs_Human1.28740572
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.28452832
66TP53_16413492_ChIP-PET_HCT116_Human1.25540352
67CJUN_26792858_Chip-Seq_BT549_Human1.24194672
68RXR_22108803_ChIP-Seq_LS180_Human1.23725707
69* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.23212652
70UBF1/2_26484160_Chip-Seq_HMECs_Human1.22926491
71BCL6_27268052_Chip-Seq_Bcells_Human1.21614807
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19816296
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.19720300
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19650912
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18455705
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17346978
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16793543
78DROSHA_22980978_ChIP-Seq_HELA_Human1.15126305
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.14852282
80GATA3_24758297_ChIP-Seq_MCF-7_Human1.12694889
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12362912
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11839206
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.11207104
84SOX2_20726797_ChIP-Seq_SW620_Human1.11112106
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.10759430
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09579995
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09511330
88CREB1_26743006_Chip-Seq_LNCaP_Human1.09078384
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07906081
90GATA6_25053715_ChIP-Seq_YYC3_Human1.07128518
91SA1_27219007_Chip-Seq_Bcells_Human1.07062200
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06370928
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06370928
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.05844919
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05443869
96TP63_23658742_ChIP-Seq_EP156T_Human1.05218183
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.03627696
98GATA6_21074721_ChIP-Seq_CACO-2_Human1.03198061
99KDM2B_26808549_Chip-Seq_K562_Human1.02562519
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02263032
101BCAT_22108803_ChIP-Seq_LS180_Human1.02239065
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01037204
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.00849061
104SMAD3_21741376_ChIP-Seq_EPCs_Human0.98759667
105* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97908513
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96671916
107SMAD3_21741376_ChIP-Seq_HESCs_Human0.96619336
108YY1_22570637_ChIP-Seq_MALME-3M_Human0.95848882
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.93549897
110PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93116424
111PHF8_20622854_ChIP-Seq_HELA_Human0.92473698
112EGR1_19032775_ChIP-ChIP_M12_Human0.92250076
113RNF2_27304074_Chip-Seq_NSC_Mouse0.91459959
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91179963
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91076957
116TCF4_22108803_ChIP-Seq_LS180_Human0.90852263
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90749333
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90390005
119CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88762782
120* AR_25329375_ChIP-Seq_VCAP_Human0.88235392
121* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87928004
122KDM2B_26808549_Chip-Seq_DND41_Human0.87119784
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86998253
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86905069
125FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86701479
126TCF7_22412390_ChIP-Seq_EML_Mouse0.86262489
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.84909539
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84334481
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84009875
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83274808
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82486890
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82245330
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81968279
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81956504
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81657864
136* RUNX1_27514584_Chip-Seq_MCF-7_Human0.80964305
137CTCF_27219007_Chip-Seq_Bcells_Human0.80627115
138* P300_27268052_Chip-Seq_Bcells_Human0.79995919
139* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79750274
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79710405
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79503076
142ERG_20517297_ChIP-Seq_VCAP_Human0.79061776
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.78471381
144DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78325703
145* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78278615
146IRF8_22096565_ChIP-ChIP_GC-B_Human0.78134230
147STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.77824155
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77517554
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77517554
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76217724
151KLF5_25053715_ChIP-Seq_YYC3_Human0.76194383
152NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76027906
153* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.75976837
154TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75907427
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75316844
156TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74786070
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74525290
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74311888
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.74289090
160VDR_21846776_ChIP-Seq_THP-1_Human0.73800493
161* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.73364124
162CTBP1_25329375_ChIP-Seq_LNCAP_Human0.72792798
163MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.72664804
164RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.72192790
165* TP63_22573176_ChIP-Seq_HFKS_Human0.72140138
166P300_19829295_ChIP-Seq_ESCs_Human0.72124527
167MYC_22102868_ChIP-Seq_BL_Human0.71410967
168TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70517428
169CDX2_20551321_ChIP-Seq_CACO-2_Human0.70325268
170FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69617435
171TBX20_22328084_ChIP-Seq_HEART_Mouse0.68010162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat9.17180970
2MP0001346_abnormal_lacrimal_gland5.21701095
3MP0005367_renal/urinary_system_phenotyp4.42950411
4MP0000516_abnormal_urinary_system4.42950411
5MP0009379_abnormal_foot_pigmentation3.96839911
6MP0000383_abnormal_hair_follicle3.44920982
7MP0000579_abnormal_nail_morphology3.38091389
8MP0003453_abnormal_keratinocyte_physiol3.35708507
9MP0002796_impaired_skin_barrier3.13565343
10* MP0002098_abnormal_vibrissa_morphology2.93038396
11MP0010678_abnormal_skin_adnexa2.89564195
12MP0003941_abnormal_skin_development2.65864494
13MP0001348_abnormal_lacrimal_gland2.60636240
14MP0010234_abnormal_vibrissa_follicle2.58792980
15MP0002938_white_spotting2.40540333
16MP0002876_abnormal_thyroid_physiology2.39169828
17MP0003878_abnormal_ear_physiology2.28431484
18MP0005377_hearing/vestibular/ear_phenot2.28431484
19MP0000647_abnormal_sebaceous_gland2.15272431
20MP0000467_abnormal_esophagus_morphology2.06674646
21MP0001188_hyperpigmentation1.97067975
22MP0002234_abnormal_pharynx_morphology1.95079653
23MP0004885_abnormal_endolymph1.90792904
24MP0005275_abnormal_skin_tensile1.88324763
25MP0000427_abnormal_hair_cycle1.87485463
26MP0002060_abnormal_skin_morphology1.86101496
27MP0004381_abnormal_hair_follicle1.82048286
28MP0001216_abnormal_epidermal_layer1.81392179
29MP0000762_abnormal_tongue_morphology1.77934387
30MP0003191_abnormal_cellular_cholesterol1.69676588
31MP0008789_abnormal_olfactory_epithelium1.69651280
32MP0000613_abnormal_salivary_gland1.65995904
33MP0000566_synostosis1.65985641
34* MP0000377_abnormal_hair_follicle1.64783345
35MP0010030_abnormal_orbit_morphology1.62947473
36MP0005409_darkened_coat_color1.62882566
37MP0004264_abnormal_extraembryonic_tissu1.62795997
38MP0004782_abnormal_surfactant_physiolog1.61850287
39MP0002277_abnormal_respiratory_mucosa1.61139371
40MP0000678_abnormal_parathyroid_gland1.59483996
41MP0005645_abnormal_hypothalamus_physiol1.59110286
42MP0005501_abnormal_skin_physiology1.55363009
43MP0001849_ear_inflammation1.54775432
44MP0005623_abnormal_meninges_morphology1.51075621
45* MP0000685_abnormal_immune_system1.42748444
46MP0010771_integument_phenotype1.42666044
47MP0005310_abnormal_salivary_gland1.37356098
48MP0003879_abnormal_hair_cell1.36295585
49MP0000733_abnormal_muscle_development1.35329821
50MP0001835_abnormal_antigen_presentation1.33221440
51MP0005023_abnormal_wound_healing1.32960795
52MP0001243_abnormal_dermal_layer1.32544950
53MP0003011_delayed_dark_adaptation1.32337825
54MP0004510_myositis1.30850435
55MP0009250_abnormal_appendicular_skeleto1.29203016
56MP0003566_abnormal_cell_adhesion1.26457385
57MP0002233_abnormal_nose_morphology1.23954674
58MP0000538_abnormal_urinary_bladder1.23574228
59MP0003755_abnormal_palate_morphology1.23142297
60MP0002177_abnormal_outer_ear1.18670515
61* MP0002095_abnormal_skin_pigmentation1.14946743
62MP0004947_skin_inflammation1.12208297
63MP0001851_eye_inflammation1.12188962
64MP0002877_abnormal_melanocyte_morpholog1.09525734
65MP0003385_abnormal_body_wall1.07169272
66MP0002932_abnormal_joint_morphology1.01506790
67MP0000465_gastrointestinal_hemorrhage1.00244361
68MP0001270_distended_abdomen1.00113372
69MP0010352_gastrointestinal_tract_polyps0.97869203
70MP0008004_abnormal_stomach_pH0.96999742
71MP0001340_abnormal_eyelid_morphology0.96797413
72MP0005508_abnormal_skeleton_morphology0.95772902
73MP0000681_abnormal_thyroid_gland0.95146122
74MP0002249_abnormal_larynx_morphology0.93454162
75MP0009780_abnormal_chondrocyte_physiolo0.90901169
76MP0000049_abnormal_middle_ear0.87486203
77MP0002111_abnormal_tail_morphology0.84764389
78MP0001873_stomach_inflammation0.84246993
79MP0003705_abnormal_hypodermis_morpholog0.84103663
80MP0005075_abnormal_melanosome_morpholog0.82350921
81MP0009053_abnormal_anal_canal0.79757393
82MP0000470_abnormal_stomach_morphology0.79339553
83MP0003942_abnormal_urinary_system0.76318433
84MP0003935_abnormal_craniofacial_develop0.75440424
85MP0009278_abnormal_bone_marrow0.74601336
86MP0004272_abnormal_basement_membrane0.74465073
87MP0000627_abnormal_mammary_gland0.74450012
88MP0000015_abnormal_ear_pigmentation0.73316356
89MP0003937_abnormal_limbs/digits/tail_de0.71575058
90MP0002116_abnormal_craniofacial_bone0.71304608
91MP0005174_abnormal_tail_pigmentation0.69572062
92* MP0003763_abnormal_thymus_physiology0.68567375
93MP0004858_abnormal_nervous_system0.66255967
94MP0002109_abnormal_limb_morphology0.64623099
95* MP0000367_abnormal_coat/_hair0.63285197
96MP0001191_abnormal_skin_condition0.63221176
97MP0000163_abnormal_cartilage_morphology0.62940146
98MP0005257_abnormal_intraocular_pressure0.60634781
99* MP0001784_abnormal_fluid_regulation0.60488298
100MP0001299_abnormal_eye_distance/0.57969948
101MP0000537_abnormal_urethra_morphology0.57570112
102MP0000428_abnormal_craniofacial_morphol0.57504446
103* MP0009931_abnormal_skin_appearance0.56856966
104MP0005499_abnormal_olfactory_system0.55996211
105MP0005394_taste/olfaction_phenotype0.55996211
106MP0005076_abnormal_cell_differentiation0.55966495
107MP0003315_abnormal_perineum_morphology0.55558763
108MP0005503_abnormal_tendon_morphology0.53520348
109MP0004185_abnormal_adipocyte_glucose0.53233739
110MP0004043_abnormal_pH_regulation0.51673059
111MP0008007_abnormal_cellular_replicative0.50785591
112MP0002115_abnormal_skeleton_extremities0.49966801
113* MP0005387_immune_system_phenotype0.49902707
114* MP0001790_abnormal_immune_system0.49902707
115MP0002697_abnormal_eye_size0.49685934
116MP0002735_abnormal_chemical_nociception0.48953648
117MP0000432_abnormal_head_morphology0.48881745
118MP0002092_abnormal_eye_morphology0.48523932
119MP0001293_anophthalmia0.48264010
120MP0005390_skeleton_phenotype0.47746038
121MP0009333_abnormal_splenocyte_physiolog0.47547021
122MP0001485_abnormal_pinna_reflex0.45134128
123MP0000703_abnormal_thymus_morphology0.44451489
124MP0002138_abnormal_hepatobiliary_system0.43894186
125MP0003938_abnormal_ear_development0.43403965
126MP0009764_decreased_sensitivity_to0.43068019
127MP0008260_abnormal_autophagy0.39458068
128MP0002006_tumorigenesis0.38280377
129MP0005666_abnormal_adipose_tissue0.32903832
130MP0009840_abnormal_foam_cell0.31990497
131MP0001984_abnormal_olfaction0.30010175
132MP0002166_altered_tumor_susceptibility0.29473431
133MP0002282_abnormal_trachea_morphology0.26219973
134MP0008057_abnormal_DNA_replication0.24444681
135MP0002009_preneoplasia0.22785821
136MP0002653_abnormal_ependyma_morphology0.21800994
137MP0001186_pigmentation_phenotype0.20234297
138MP0005647_abnormal_sex_gland0.19146356
139* MP0003638_abnormal_response/metabolism_0.17629526
140MP0000462_abnormal_digestive_system0.16273544
141MP0004197_abnormal_fetal_growth/weight/0.16073347
142MP0002148_abnormal_hypersensitivity_rea0.16045709
143MP0001958_emphysema0.15882030
144* MP0005025_abnormal_response_to0.15105462
145MP0005451_abnormal_body_composition0.14988597

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.34532330
2Erythroderma (HP:0001019)6.92373231
3Congenital ichthyosiform erythroderma (HP:0007431)6.69112351
4Nasolacrimal duct obstruction (HP:0000579)6.33670560
5Hypotrichosis (HP:0001006)6.18237919
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.04744940
7Alacrima (HP:0000522)6.02202313
8Abnormality of the lacrimal duct (HP:0011481)5.94816495
9Woolly hair (HP:0002224)5.94655685
10Onycholysis (HP:0001806)5.91000764
11Plantar hyperkeratosis (HP:0007556)5.87567132
12Lip pit (HP:0100267)5.60774706
13Pili torti (HP:0003777)5.59186528
14Milia (HP:0001056)5.38261294
15Abnormality of the nasolacrimal system (HP:0000614)5.18591696
16Mixed hearing impairment (HP:0000410)5.18303628
17Corneal erosion (HP:0200020)5.08000272
18Fragile nails (HP:0001808)5.02994177
19Palmoplantar hyperkeratosis (HP:0000972)4.85220702
20Decreased lacrimation (HP:0000633)4.83539652
21Oral leukoplakia (HP:0002745)4.77450504
22Natal tooth (HP:0000695)4.73653178
23Preauricular pit (HP:0004467)4.67997608
24Periauricular skin pits (HP:0100277)4.67997608
25Conjunctival hamartoma (HP:0100780)4.66786854
26Palmar hyperkeratosis (HP:0010765)4.59134146
27Microretrognathia (HP:0000308)4.46603018
28Nail dystrophy (HP:0008404)4.21884453
29Palmoplantar keratoderma (HP:0000982)3.93584842
30Abnormality of the salivary glands (HP:0010286)3.84941386
31Skin pits (HP:0100276)3.79985002
32Atrophic scars (HP:0001075)3.76296834
33Scapular winging (HP:0003691)3.71359348
34Advanced eruption of teeth (HP:0006288)3.55053564
35Abnormality of the gastric mucosa (HP:0004295)3.48747228
36Aplasia cutis congenita (HP:0001057)3.48089845
37Abnormal hair laboratory examination (HP:0003328)3.47544859
38Selective tooth agenesis (HP:0001592)3.43448770
39Sparse eyelashes (HP:0000653)3.30177460
40Gangrene (HP:0100758)3.25186011
41Unilateral renal agenesis (HP:0000122)3.21346980
42Blepharitis (HP:0000498)3.21102794
43Hamartoma of the eye (HP:0010568)3.16310454
44Abnormality of the antihelix (HP:0009738)3.15123623
45Chronic mucocutaneous candidiasis (HP:0002728)3.01815175
46Recurrent cutaneous fungal infections (HP:0011370)3.01815175
47Amelogenesis imperfecta (HP:0000705)2.99331741
48Absent eyelashes (HP:0000561)2.96839067
49Parakeratosis (HP:0001036)2.95078027
50Hypoplasia of dental enamel (HP:0006297)2.94216208
51Sparse scalp hair (HP:0002209)2.89960864
52Ventricular fibrillation (HP:0001663)2.85479110
53Abnormality of nail color (HP:0100643)2.79484459
54Intellectual disability, moderate (HP:0002342)2.78976373
55Absent eyebrow (HP:0002223)2.76002972
56Abnormality of hair growth rate (HP:0011363)2.70914605
57Slow-growing hair (HP:0002217)2.70914605
58Hypoplastic labia majora (HP:0000059)2.66261767
59Ventricular tachycardia (HP:0004756)2.59635236
60Pruritus (HP:0000989)2.51651086
61Morphological abnormality of the middle ear (HP:0008609)2.45766808
62Increased IgE level (HP:0003212)2.45466037
63Premature loss of primary teeth (HP:0006323)2.44609445
64Alopecia of scalp (HP:0002293)2.44263678
65Abnormality of the labia majora (HP:0012881)2.42453998
66Chronic otitis media (HP:0000389)2.40722804
67Abnormal blistering of the skin (HP:0008066)2.37564524
68Follicular hyperkeratosis (HP:0007502)2.37457475
69Abnormality of the neuromuscular junction (HP:0003398)2.34009002
70Fatigable weakness (HP:0003473)2.34009002
71Oligodontia (HP:0000677)2.32721289
72Fragile skin (HP:0001030)2.32247278
73Hypergammaglobulinemia (HP:0010702)2.30074626
74Pterygium (HP:0001059)2.25635437
75Aplasia/Hypoplasia of the spleen (HP:0010451)2.24627910
76Hypohidrosis (HP:0000966)2.24551815
77Abnormality of the dental root (HP:0006486)2.22114129
78Taurodontia (HP:0000679)2.22114129
79Abnormality of permanent molar morphology (HP:0011071)2.22114129
80Esophageal atresia (HP:0002032)2.21981898
81Acanthosis nigricans (HP:0000956)2.21458238
82Furrowed tongue (HP:0000221)2.20626452
83Abnormality of the axillary hair (HP:0100134)2.17086578
84Abnormality of secondary sexual hair (HP:0009888)2.17086578
85Depressed nasal tip (HP:0000437)2.15286831
86Split foot (HP:0001839)2.14768365
87Sprengel anomaly (HP:0000912)2.14660738
88Duplicated collecting system (HP:0000081)2.11088779
89Amniotic constriction ring (HP:0009775)2.10132576
90Abnormality of placental membranes (HP:0011409)2.10132576
91Abnormality of molar morphology (HP:0011070)2.09625559
92Abnormality of molar (HP:0011077)2.09625559
93Abnormality of the shoulder girdle musculature (HP:0001435)2.04450304
94Brittle hair (HP:0002299)2.03259441
95Atresia of the external auditory canal (HP:0000413)2.02007393
96Pustule (HP:0200039)2.00198815
97Melanocytic nevus (HP:0000995)1.99980519
98Abnormality of the dental pulp (HP:0006479)1.96225908
99Skin ulcer (HP:0200042)1.95904278
100Ectropion (HP:0000656)1.95563085
101Septate vagina (HP:0001153)1.95230775
102Anhidrosis (HP:0000970)1.94582086
103Popliteal pterygium (HP:0009756)1.94325336
104Xerostomia (HP:0000217)1.93410675
105Abnormality of calcium-phosphate metabolism (HP:0100530)1.91967115
106Malnutrition (HP:0004395)1.90810562
107Seborrheic dermatitis (HP:0001051)1.90369255
108Carious teeth (HP:0000670)1.89809688
109Dehydration (HP:0001944)1.88877098
110Thick nail (HP:0001805)1.88830394
111Keratoconjunctivitis (HP:0001096)1.87578324
112Hypodontia (HP:0000668)1.86323191
113Periodontitis (HP:0000704)1.86025630
114Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.84495693
115Asplenia (HP:0001746)1.84084271
116Type I diabetes mellitus (HP:0100651)1.83589930
117Abnormality of the renal collecting system (HP:0004742)1.82115534
118Conical tooth (HP:0000698)1.81550781
119Multifactorial inheritance (HP:0001426)1.80109213
120Hamartoma (HP:0010566)1.79039705
121Ridged nail (HP:0001807)1.78987316
122Dry hair (HP:0011359)1.78181936
123Recurrent corneal erosions (HP:0000495)1.77662933
124Absent hair (HP:0002298)1.77331129
125Erythema (HP:0010783)1.76575993
126Hyperhidrosis (HP:0000975)1.76571364
127Neonatal death (HP:0003811)1.76305511
128Abnormal delayed hypersensitivity skin test (HP:0002963)1.74301852
129Lack of skin elasticity (HP:0100679)1.70899463
130Weak cry (HP:0001612)1.68158311
131Absent hand (HP:0004050)1.67899438
132Squamous cell carcinoma (HP:0002860)1.67621718
133Breast hypoplasia (HP:0003187)1.66009564
134Ureteral stenosis (HP:0000071)1.65378617
135Microdontia (HP:0000691)1.64228225
136Urticaria (HP:0001025)1.63556549
137Ventricular arrhythmia (HP:0004308)1.63321725
138Cutaneous finger syndactyly (HP:0010554)1.63129958
139Dry skin (HP:0000958)1.61474212
140Abnormality of proline metabolism (HP:0010907)1.61464263
141Hydroxyprolinuria (HP:0003080)1.61464263
142Eczematoid dermatitis (HP:0000976)1.61146424
143Bilateral microphthalmos (HP:0007633)1.57657567
144Ankyloglossia (HP:0010296)1.57466474
145Fine hair (HP:0002213)1.56859058
146Abnormality of the fingernails (HP:0001231)1.53816859
147Anonychia (HP:0001798)1.53740123
148Ureteral obstruction (HP:0006000)1.52979526
149Verrucae (HP:0200043)1.52464499
150Papilloma (HP:0012740)1.52464499
151Sex reversal (HP:0012245)1.52263764
152Abnormal sex determination (HP:0012244)1.52263764
153Upper limb muscle weakness (HP:0003484)1.52107646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.69471579
2LATS14.02296153
3TESK23.83600400
4MAP3K143.43148054
5SMG13.08572182
6MAP3K63.08231084
7EPHB12.53827360
8FER2.49087383
9EPHA32.24662269
10SIK12.22277742
11PTK62.18684100
12TTN2.17454964
13ERBB32.15625299
14MUSK2.10760008
15EEF2K2.08936125
16FGFR42.02645569
17RPS6KB22.00079389
18EPHB21.98290291
19SIK31.95296050
20TRIB31.94289679
21ERN11.77731472
22CDC42BPA1.65695823
23FGFR11.63971428
24CDK121.61872342
25MST41.54499039
26BMPR1B1.54217840
27IKBKE1.52307931
28FGFR31.50547642
29GRK61.46430524
30MAP3K31.43723738
31BMPR21.41323528
32NME11.41236479
33JAK11.38176914
34TYK21.34182935
35ERBB21.34128232
36CHUK1.33686546
37MAP3K21.33290003
38EPHA21.31258030
39STK38L1.26765055
40FGFR21.26408674
41PRPF4B1.25160436
42CDK31.23833197
43TGFBR11.22510196
44NLK1.18403372
45JAK31.14571840
46TSSK61.14163176
47VRK21.13103578
48ZAK1.12581379
49BTK1.09616053
50MAPKAPK21.09194941
51NTRK21.08807932
52DYRK1B1.04825284
53LATS21.04566799
54STK31.03308344
55PTK21.02134250
56MAPK70.99485184
57TAOK10.98929817
58ICK0.97155972
59PRKD20.95962186
60MST1R0.95026634
61JAK20.94995516
62RIPK10.94020394
63IKBKB0.93679956
64TRPM70.92913383
65EIF2AK20.87630076
66MAP2K60.87261947
67GRK10.86838939
68PRKD30.85725856
69MTOR0.82855561
70DYRK30.82361112
71STK240.82161843
72MARK20.81904221
73MAP3K130.80094364
74CDK80.79697317
75LRRK20.79341426
76SIK20.76946563
77CDK70.75649478
78NUAK10.75167896
79TGFBR20.74883206
80FRK0.74743095
81NME20.72069605
82DDR20.71748336
83RPS6KB10.71598845
84PDK20.71453966
85CAMK2G0.70454346
86MAP2K20.70333526
87PBK0.67823299
88MAP3K70.66142715
89IRAK10.65432593
90TAF10.64411596
91MAPK120.63418445
92LMTK20.61092330
93PKN20.61053776
94NEK60.60097450
95TNIK0.59207920
96TBK10.57789255
97HIPK20.57535329
98ERBB40.56625377
99PRKCE0.55622185
100RPS6KA20.53925453
101ITK0.53368120
102PIK3CG0.51849296
103CLK10.51395368
104MAPKAPK50.50849777
105CDK90.50074147
106CAMK40.49443994
107MAPK110.48923001
108MAPKAPK30.47924620
109PIM20.47916487
110MAP3K100.47137274
111MET0.45944279
112VRK10.45490342
113GSK3A0.44120573
114PASK0.43957621
115PAK20.43217440
116RPS6KA10.41799130
117DMPK0.41220428
118RET0.41095264
119PDGFRA0.40094779
120TYRO30.38959022
121SRC0.38098878
122GRK50.37899477
123ADRBK10.37836636
124IRAK40.36968715
125IRAK30.36535576
126CAMK2B0.36455808
127NTRK30.36326149
128PRKAA20.36035814
129MAP2K10.35593965
130PKN10.35053465
131EPHA40.33041870
132RPS6KA40.31992922
133MAP3K10.30761283
134BCR0.28944537
135MAP3K90.28914514
136ROCK20.28646081
137EIF2AK10.28524547
138CAMK10.27982773
139PRKD10.24867869
140PRKCI0.23658290
141MAPK90.23146671
142GRK70.16484269
143SGK2230.13917687
144SGK4940.13917687
145HCK0.13784056
146MELK0.13609806
147MAPK30.12971201
148KIT0.12643733

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.73102165
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.62435111
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.41481235
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.38343945
5VEGF signaling pathway_Homo sapiens_hsa043702.37535552
6Antigen processing and presentation_Homo sapiens_hsa046122.36838714
7Basal cell carcinoma_Homo sapiens_hsa052172.33483960
8Ovarian steroidogenesis_Homo sapiens_hsa049132.11954770
9Hippo signaling pathway_Homo sapiens_hsa043901.99889962
10Histidine metabolism_Homo sapiens_hsa003401.93737572
11Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.92807951
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.87716079
13ECM-receptor interaction_Homo sapiens_hsa045121.87392472
14Asthma_Homo sapiens_hsa053101.83763614
15Notch signaling pathway_Homo sapiens_hsa043301.80200961
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.79836781
17Primary immunodeficiency_Homo sapiens_hsa053401.79699627
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.78084834
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68687996
20Fatty acid elongation_Homo sapiens_hsa000621.62850788
21Toxoplasmosis_Homo sapiens_hsa051451.62086157
22Staphylococcus aureus infection_Homo sapiens_hsa051501.60731574
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.58151327
24Linoleic acid metabolism_Homo sapiens_hsa005911.55602113
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52096872
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48579531
27Choline metabolism in cancer_Homo sapiens_hsa052311.45234148
28Hedgehog signaling pathway_Homo sapiens_hsa043401.43418532
29Small cell lung cancer_Homo sapiens_hsa052221.42501101
30Axon guidance_Homo sapiens_hsa043601.42014442
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39203190
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37214045
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35245755
34Adherens junction_Homo sapiens_hsa045201.33230203
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.32695140
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30322736
37Phenylalanine metabolism_Homo sapiens_hsa003601.29949333
38Acute myeloid leukemia_Homo sapiens_hsa052211.28151763
39TNF signaling pathway_Homo sapiens_hsa046681.23633291
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21414136
41ABC transporters_Homo sapiens_hsa020101.18625412
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18497838
43Amoebiasis_Homo sapiens_hsa051461.16193079
44Ether lipid metabolism_Homo sapiens_hsa005651.13974976
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.13914790
46Osteoclast differentiation_Homo sapiens_hsa043801.10258670
47Arachidonic acid metabolism_Homo sapiens_hsa005901.10252761
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09648983
49Melanogenesis_Homo sapiens_hsa049161.06796426
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05329983
51Proteoglycans in cancer_Homo sapiens_hsa052051.02726896
52Leishmaniasis_Homo sapiens_hsa051401.02597503
53Influenza A_Homo sapiens_hsa051641.02435277
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99985818
55Long-term depression_Homo sapiens_hsa047300.99268273
56Glioma_Homo sapiens_hsa052140.91977808
57Melanoma_Homo sapiens_hsa052180.91503016
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91282501
59Sphingolipid metabolism_Homo sapiens_hsa006000.90994767
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90621421
61Pathways in cancer_Homo sapiens_hsa052000.90206070
62Focal adhesion_Homo sapiens_hsa045100.88893617
63Renin secretion_Homo sapiens_hsa049240.88312540
64African trypanosomiasis_Homo sapiens_hsa051430.87548218
65Wnt signaling pathway_Homo sapiens_hsa043100.83808573
66Prolactin signaling pathway_Homo sapiens_hsa049170.83516576
67Rheumatoid arthritis_Homo sapiens_hsa053230.80361199
68Vitamin digestion and absorption_Homo sapiens_hsa049770.79048233
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77467025
70Herpes simplex infection_Homo sapiens_hsa051680.76788986
71Cocaine addiction_Homo sapiens_hsa050300.76555669
72Chemokine signaling pathway_Homo sapiens_hsa040620.75960438
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75777746
74Circadian rhythm_Homo sapiens_hsa047100.75593859
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.75270969
76Inositol phosphate metabolism_Homo sapiens_hsa005620.75068909
77Dorso-ventral axis formation_Homo sapiens_hsa043200.72982406
78TGF-beta signaling pathway_Homo sapiens_hsa043500.72808630
79Hepatitis C_Homo sapiens_hsa051600.72234912
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.71997190
81Tuberculosis_Homo sapiens_hsa051520.71306004
82HTLV-I infection_Homo sapiens_hsa051660.71093602
83Tight junction_Homo sapiens_hsa045300.71003550
84Nicotine addiction_Homo sapiens_hsa050330.70885518
85Insulin resistance_Homo sapiens_hsa049310.70846431
86Bladder cancer_Homo sapiens_hsa052190.70586805
87Pancreatic cancer_Homo sapiens_hsa052120.68875191
88Serotonergic synapse_Homo sapiens_hsa047260.67927331
89Legionellosis_Homo sapiens_hsa051340.65370452
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.65294566
91Measles_Homo sapiens_hsa051620.64741632
92Amphetamine addiction_Homo sapiens_hsa050310.64405389
93MicroRNAs in cancer_Homo sapiens_hsa052060.63570716
94Apoptosis_Homo sapiens_hsa042100.63431448
95Ras signaling pathway_Homo sapiens_hsa040140.62796541
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60255522
97Endometrial cancer_Homo sapiens_hsa052130.58863913
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58558210
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.57653199
100Retinol metabolism_Homo sapiens_hsa008300.56802151
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56537519
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56259510
103Rap1 signaling pathway_Homo sapiens_hsa040150.55682372
104Glycerolipid metabolism_Homo sapiens_hsa005610.54676367
105ErbB signaling pathway_Homo sapiens_hsa040120.53538912
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.52979449
107Pertussis_Homo sapiens_hsa051330.52685535
108Estrogen signaling pathway_Homo sapiens_hsa049150.52495358
109Oxytocin signaling pathway_Homo sapiens_hsa049210.51584156
110Hematopoietic cell lineage_Homo sapiens_hsa046400.51580903
111Sulfur metabolism_Homo sapiens_hsa009200.50710021
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50506498
113PPAR signaling pathway_Homo sapiens_hsa033200.50455854
114Autoimmune thyroid disease_Homo sapiens_hsa053200.50432285
115Insulin signaling pathway_Homo sapiens_hsa049100.50202770
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49140068
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49126056
118Taste transduction_Homo sapiens_hsa047420.49108478
119MAPK signaling pathway_Homo sapiens_hsa040100.48645728
120Endocytosis_Homo sapiens_hsa041440.48560524
121beta-Alanine metabolism_Homo sapiens_hsa004100.48492051
122p53 signaling pathway_Homo sapiens_hsa041150.48238405
123Platelet activation_Homo sapiens_hsa046110.47820307
124Gastric acid secretion_Homo sapiens_hsa049710.47776340
125Hepatitis B_Homo sapiens_hsa051610.47094858
126Glucagon signaling pathway_Homo sapiens_hsa049220.45981709
127Protein digestion and absorption_Homo sapiens_hsa049740.45505909
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44911934
129Calcium signaling pathway_Homo sapiens_hsa040200.44527192
130Thyroid cancer_Homo sapiens_hsa052160.44324064
131Prostate cancer_Homo sapiens_hsa052150.44135456
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43567006
133Salivary secretion_Homo sapiens_hsa049700.43187537
134Tyrosine metabolism_Homo sapiens_hsa003500.43180247
135GnRH signaling pathway_Homo sapiens_hsa049120.42840037
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41624864
137Fatty acid biosynthesis_Homo sapiens_hsa000610.41029023
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.39781473
139Pancreatic secretion_Homo sapiens_hsa049720.39403928
140Fat digestion and absorption_Homo sapiens_hsa049750.37549004
141Arginine biosynthesis_Homo sapiens_hsa002200.34571090
142mTOR signaling pathway_Homo sapiens_hsa041500.31817453
143Lysine degradation_Homo sapiens_hsa003100.31289968
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30934982
145Long-term potentiation_Homo sapiens_hsa047200.29772711
146Lysosome_Homo sapiens_hsa041420.28563121
147Allograft rejection_Homo sapiens_hsa053300.27767223
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25948195

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