FOXN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.23461953
2positive regulation of gamma-delta T cell activation (GO:0046645)5.06200943
3nuclear pore complex assembly (GO:0051292)4.28007433
4hepatocyte apoptotic process (GO:0097284)4.13060446
5positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.97056518
6response to interleukin-15 (GO:0070672)3.89731230
7mitotic metaphase plate congression (GO:0007080)3.85650780
8positive regulation of B cell differentiation (GO:0045579)3.81624714
9positive regulation of granulocyte differentiation (GO:0030854)3.81506670
10cellular extravasation (GO:0045123)3.69740951
11activated T cell proliferation (GO:0050798)3.68690400
12neutrophil activation involved in immune response (GO:0002283)3.60609943
13mitochondrial DNA replication (GO:0006264)3.60165133
14meiotic chromosome segregation (GO:0045132)3.58655955
15pore complex assembly (GO:0046931)3.55399039
16nuclear pore organization (GO:0006999)3.54919645
17NIK/NF-kappaB signaling (GO:0038061)3.52220522
18cellular response to interleukin-15 (GO:0071350)3.52148877
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.51335550
20negative regulation of cell killing (GO:0031342)3.51134208
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.51134208
22neural tube formation (GO:0001841)3.50171956
23protein localization to kinetochore (GO:0034501)3.47791324
24negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.45016359
25monoubiquitinated protein deubiquitination (GO:0035520)3.39808379
26establishment of chromosome localization (GO:0051303)3.39523683
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38867144
28production of molecular mediator involved in inflammatory response (GO:0002532)3.37700678
29detection of molecule of bacterial origin (GO:0032490)3.35210057
30positive T cell selection (GO:0043368)3.34167724
31negative regulation of T cell mediated immunity (GO:0002710)3.32284359
32poly(A)+ mRNA export from nucleus (GO:0016973)3.32196872
33regulation of gamma-delta T cell activation (GO:0046643)3.30648075
34microglial cell activation (GO:0001774)3.28155720
35regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27856366
36metaphase plate congression (GO:0051310)3.27648970
37regulation of RIG-I signaling pathway (GO:0039535)3.27359259
38regulation of B cell differentiation (GO:0045577)3.21354022
39protein localization to chromosome, centromeric region (GO:0071459)3.20376602
40histone H3-K9 demethylation (GO:0033169)3.20054699
41negative regulation of interleukin-12 production (GO:0032695)3.17980910
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15817779
43negative regulation of T-helper cell differentiation (GO:0045623)3.09948303
44negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.09948303
45regulation of DNA endoreduplication (GO:0032875)3.08719698
46cellular response to ethanol (GO:0071361)3.08609467
47interferon-gamma production (GO:0032609)3.08144576
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.06892412
49B cell receptor signaling pathway (GO:0050853)3.05595358
50phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.05096041
51regulation of gamma-delta T cell differentiation (GO:0045586)3.05027787
52neutrophil activation (GO:0042119)3.04876951
53regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01327328
54regulation of T cell tolerance induction (GO:0002664)3.00651892
55positive regulation of mast cell activation (GO:0033005)2.99048666
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96825814
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96825814
58positive regulation of mitotic sister chromatid separation (GO:1901970)2.96825814
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96280940
60macrophage activation involved in immune response (GO:0002281)2.95198196
61positive regulation of alpha-beta T cell proliferation (GO:0046641)2.94254214
62regulation of tolerance induction (GO:0002643)2.93220835
63myoblast migration (GO:0051451)2.92567621
64positive regulation of antigen processing and presentation (GO:0002579)2.92384652
65myeloid cell activation involved in immune response (GO:0002275)2.92314508
66neutrophil mediated immunity (GO:0002446)2.87452495
67immunoglobulin mediated immune response (GO:0016064)2.85594895
68positive regulation of protein import into nucleus, translocation (GO:0033160)2.83994359
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.83059600
70regulation of T cell chemotaxis (GO:0010819)2.82035717
71positive regulation of T cell chemotaxis (GO:0010820)2.82035717
72protein K11-linked deubiquitination (GO:0035871)2.81818511
73modulation by symbiont of host cellular process (GO:0044068)2.80452214
74myeloid dendritic cell activation (GO:0001773)2.79947023
75granulocyte activation (GO:0036230)2.79882320
76CENP-A containing nucleosome assembly (GO:0034080)2.78726530
77mast cell activation (GO:0045576)2.78605610
78detection of biotic stimulus (GO:0009595)2.78529301
79regulation of antigen processing and presentation (GO:0002577)2.77474121
80negative regulation of lymphocyte mediated immunity (GO:0002707)2.74678633
81resolution of meiotic recombination intermediates (GO:0000712)2.74406710
82kinetochore organization (GO:0051383)2.74170692
83negative regulation of B cell proliferation (GO:0030889)2.73332469
84negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.73303833
85response to peptidoglycan (GO:0032494)2.73016492
86interferon-gamma-mediated signaling pathway (GO:0060333)2.71817511
87regulation of double-strand break repair via homologous recombination (GO:0010569)2.71288778
88modulation by virus of host process (GO:0019054)2.71152951
89attachment of spindle microtubules to kinetochore (GO:0008608)2.70071981
90detection of other organism (GO:0098543)2.69196476
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.68572399
92regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.66249655
93regulation of mitotic spindle checkpoint (GO:1903504)2.65944316
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65944316
95DNA replication checkpoint (GO:0000076)2.65885881
96regulation of hypersensitivity (GO:0002883)2.65738828
97negative thymic T cell selection (GO:0045060)2.65280713
98regulation of spindle organization (GO:0090224)2.64982820
99response to muramyl dipeptide (GO:0032495)2.63996115
100leukocyte degranulation (GO:0043299)2.63914829
101regulation of mast cell activation (GO:0033003)2.63346979
102regulation of interleukin-8 biosynthetic process (GO:0045414)2.63325655
103detection of external biotic stimulus (GO:0098581)2.62740951
104positive regulation of chromosome segregation (GO:0051984)2.62672263
105regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.61773006
106regulation of fibroblast apoptotic process (GO:2000269)2.61059057
107negative regulation of adaptive immune response (GO:0002820)2.60921008
108histone lysine demethylation (GO:0070076)2.60244396
109macrophage activation (GO:0042116)2.60004795
110positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.59851622
111histone demethylation (GO:0016577)2.59608858
112negative T cell selection (GO:0043383)2.59317765
113natural killer cell mediated cytotoxicity (GO:0042267)2.59241751
114natural killer cell mediated immunity (GO:0002228)2.59241751
115peptidyl-lysine trimethylation (GO:0018023)2.59111867
116myeloid dendritic cell differentiation (GO:0043011)2.58787413
117chromatin remodeling at centromere (GO:0031055)2.58289122
118G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.58188585
119myeloid leukocyte mediated immunity (GO:0002444)2.56825099
120protein K6-linked ubiquitination (GO:0085020)2.56656882
121negative regulation of mast cell activation (GO:0033004)2.56451718
122maturation of 5.8S rRNA (GO:0000460)2.55867838
123response to host immune response (GO:0052572)2.55554807
124response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55554807
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54746703
126histone mRNA catabolic process (GO:0071044)2.54454859
127necroptotic process (GO:0070266)2.54452791
128positive regulation of protein homooligomerization (GO:0032464)2.53801218
129mitotic cell cycle arrest (GO:0071850)2.53628543
130regulation of interferon-beta biosynthetic process (GO:0045357)2.53066709
131regulation of histone H3-K27 methylation (GO:0061085)2.53018059
132mitotic chromosome condensation (GO:0007076)2.52778209
133T cell migration (GO:0072678)2.51850098
134mitotic sister chromatid segregation (GO:0000070)2.51686609
135defense response to protozoan (GO:0042832)2.51601243
136T cell selection (GO:0045058)2.51148086
137antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51078108
138mature B cell differentiation (GO:0002335)2.49936256
139histone H3-K4 trimethylation (GO:0080182)2.49655468
140positive regulation by symbiont of host defense response (GO:0052509)2.49578060
141modulation by symbiont of host defense response (GO:0052031)2.49578060
142modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49578060
143modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49578060
144positive regulation by organism of defense response of other organism involved in symbiotic interact2.49578060
145modulation by symbiont of host immune response (GO:0052553)2.49578060
146necrotic cell death (GO:0070265)2.49249744
147replication fork processing (GO:0031297)2.49024985
148leukocyte aggregation (GO:0070486)2.49008291
149positive regulation of toll-like receptor signaling pathway (GO:0034123)2.48594401
150T cell proliferation (GO:0042098)2.47516850
151regulation of activation of Janus kinase activity (GO:0010533)2.47187593
152antigen processing and presentation via MHC class Ib (GO:0002475)2.46558836
153kinetochore assembly (GO:0051382)2.45937687
154dendritic cell chemotaxis (GO:0002407)2.45915184
155positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45889579
156regulation of granulocyte differentiation (GO:0030852)2.45012834
157B cell mediated immunity (GO:0019724)2.44379279
158regulation of establishment of cell polarity (GO:2000114)2.44247992
159DNA replication-independent nucleosome assembly (GO:0006336)2.44245388
160DNA replication-independent nucleosome organization (GO:0034724)2.44245388
161chromosome segregation (GO:0007059)2.41812585
162sister chromatid segregation (GO:0000819)2.41066287
163positive regulation of T cell migration (GO:2000406)2.38898685
164positive regulation of interferon-alpha production (GO:0032727)2.38130922
165mitotic G2/M transition checkpoint (GO:0044818)2.36913650
166regulation of mitotic spindle organization (GO:0060236)2.35389103
167regulation of alpha-beta T cell proliferation (GO:0046640)2.35368246
168spindle checkpoint (GO:0031577)2.34644995
169protein localization to chromosome (GO:0034502)2.34319527
170positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.33946147
171regulation of B cell receptor signaling pathway (GO:0050855)2.33091244
172positive regulation of leukocyte apoptotic process (GO:2000108)2.32237338
173microtubule depolymerization (GO:0007019)2.31329427
174antigen processing and presentation of endogenous antigen (GO:0019883)2.30404375
175regulation of interferon-alpha production (GO:0032647)2.30258685
176dendritic cell migration (GO:0036336)2.29615391
177Arp2/3 complex-mediated actin nucleation (GO:0034314)2.29504782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.59744873
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.15048725
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.00394665
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.89713493
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68202464
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41552060
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.99438442
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82901170
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.65440463
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64554097
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57787200
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.49303618
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.47410869
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36249207
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.33284073
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.33246868
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30960682
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12052422
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11899674
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04692409
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03313809
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99101007
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.96039544
24* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93706757
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.91466435
26VDR_22108803_ChIP-Seq_LS180_Human1.85934575
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.81622589
28TAF15_26573619_Chip-Seq_HEK293_Human1.80287173
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78920366
30* SPI1_23547873_ChIP-Seq_NB4_Human1.75170473
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.70136853
32MYB_26560356_Chip-Seq_TH2_Human1.66706993
33ELK1_19687146_ChIP-ChIP_HELA_Human1.65355726
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62578897
35* MYB_26560356_Chip-Seq_TH1_Human1.62334707
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61646606
37* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60782192
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58499310
39AR_21909140_ChIP-Seq_LNCAP_Human1.57624343
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57545494
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56998269
42CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.55795114
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54406358
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46419522
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45373790
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43350679
47RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42877694
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.42721766
49RUNX_20019798_ChIP-Seq_JUKART_Human1.40382540
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37600363
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37100721
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37056843
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36106660
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.35386358
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33522535
56P300_19829295_ChIP-Seq_ESCs_Human1.32082713
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31449920
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.31038512
59GATA1_22025678_ChIP-Seq_K562_Human1.30707953
60* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.29730485
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.28377663
62* VDR_23849224_ChIP-Seq_CD4+_Human1.27987092
63ER_23166858_ChIP-Seq_MCF-7_Human1.27813322
64OCT4_21477851_ChIP-Seq_ESCs_Mouse1.27639257
65PU_27001747_Chip-Seq_BMDM_Mouse1.26129138
66SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.24312406
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.23134363
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21951867
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.21424352
70P53_22387025_ChIP-Seq_ESCs_Mouse1.21400442
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21117222
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21042787
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20743996
74SALL4_22934838_ChIP-ChIP_CD34+_Human1.20254597
75P300_18555785_Chip-Seq_ESCs_Mouse1.20017307
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19950018
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19592464
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18797155
79FUS_26573619_Chip-Seq_HEK293_Human1.18459752
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16870459
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16097046
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15660915
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14962983
84* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14933456
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14262307
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12821729
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12575470
88ZNF274_21170338_ChIP-Seq_K562_Hela1.11621534
89NMYC_18555785_Chip-Seq_ESCs_Mouse1.11574196
90* RUNX1_22412390_ChIP-Seq_EML_Mouse1.11132371
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.09548102
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08640922
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08597350
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.07915183
95EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06904007
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.06656757
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05334511
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05178660
99TFEB_21752829_ChIP-Seq_HELA_Human1.04858700
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02521051
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02515487
102SOX2_18555785_Chip-Seq_ESCs_Mouse1.02417860
103STAT3_23295773_ChIP-Seq_U87_Human1.02113322
104VDR_24787735_ChIP-Seq_THP-1_Human1.01705447
105BCAT_22108803_ChIP-Seq_LS180_Human1.00976221
106MAF_26560356_Chip-Seq_TH1_Human1.00946160
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.00783621
108RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99852678
109SMAD4_21799915_ChIP-Seq_A2780_Human0.99725316
110TCF4_18268006_ChIP-ChIP_LS174T_Human0.97669992
111GBX2_23144817_ChIP-Seq_PC3_Human0.97166621
112SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96396100
113GABP_17652178_ChIP-ChIP_JURKAT_Human0.94401729
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93785058
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93157640
116MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91579012
117GATA3_26560356_Chip-Seq_TH2_Human0.91018188
118SCL_19346495_ChIP-Seq_HPC-7_Human0.90158741
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90023768
120NFE2_27457419_Chip-Seq_LIVER_Mouse0.89120470
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88423042
122GATA3_27048872_Chip-Seq_THYMUS_Human0.88279727
123* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86765848
124POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85912576
125EZH2_27294783_Chip-Seq_NPCs_Mouse0.84218095
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83935233
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83079216
128EWS_26573619_Chip-Seq_HEK293_Human0.82734280
129* MYC_22102868_ChIP-Seq_BL_Human0.81730576
130FOXP3_21729870_ChIP-Seq_TREG_Human0.81688891
131GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80979893
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80371894
133KDM5A_27292631_Chip-Seq_BREAST_Human0.80124188
134IGF1R_20145208_ChIP-Seq_DFB_Human0.79809311
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79484529
136VDR_24763502_ChIP-Seq_THP-1_Human0.78054225
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77642234
138BRD4_25478319_ChIP-Seq_HGPS_Human0.77637812
139YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76618777
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.75097445
141* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74897512
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74584799
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74584799
144ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73906851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.85369584
2MP0008057_abnormal_DNA_replication3.58537338
3MP0003693_abnormal_embryo_hatching3.25751504
4MP0002006_tumorigenesis2.43055489
5MP0002148_abnormal_hypersensitivity_rea2.40996270
6MP0010094_abnormal_chromosome_stability2.39726197
7MP0003436_decreased_susceptibility_to2.36850775
8MP0008007_abnormal_cellular_replicative2.31287683
9MP0005671_abnormal_response_to2.30403672
10MP0002396_abnormal_hematopoietic_system2.30330799
11MP0002009_preneoplasia2.26491509
12MP0002166_altered_tumor_susceptibility2.22662132
13MP0005000_abnormal_immune_tolerance2.15515230
14MP0005387_immune_system_phenotype2.15469416
15MP0001790_abnormal_immune_system2.15469416
16MP0003077_abnormal_cell_cycle2.14560295
17MP0003111_abnormal_nucleus_morphology2.13243853
18MP0001800_abnormal_humoral_immune2.13013429
19MP0002452_abnormal_antigen_presenting2.09248902
20MP0002419_abnormal_innate_immunity2.07962976
21MP0009785_altered_susceptibility_to2.06935989
22MP0000685_abnormal_immune_system1.96433973
23MP0003763_abnormal_thymus_physiology1.94635141
24MP0002877_abnormal_melanocyte_morpholog1.94068444
25MP0002723_abnormal_immune_serum1.91630915
26MP0001819_abnormal_immune_cell1.90412231
27MP0002420_abnormal_adaptive_immunity1.88371612
28MP0008058_abnormal_DNA_repair1.87547733
29MP0000569_abnormal_digit_pigmentation1.87294154
30MP0010307_abnormal_tumor_latency1.81478568
31MP0009333_abnormal_splenocyte_physiolog1.78276666
32MP0005025_abnormal_response_to1.77561477
33MP0002398_abnormal_bone_marrow1.72887665
34MP0003172_abnormal_lysosome_physiology1.72854721
35MP0003656_abnormal_erythrocyte_physiolo1.61754302
36MP0003448_altered_tumor_morphology1.58710723
37MP0002163_abnormal_gland_morphology1.54340521
38MP0005451_abnormal_body_composition1.52346491
39MP0000716_abnormal_immune_system1.52188979
40MP0005310_abnormal_salivary_gland1.49636622
41MP0002405_respiratory_system_inflammati1.48786366
42MP0002277_abnormal_respiratory_mucosa1.47861672
43MP0000465_gastrointestinal_hemorrhage1.43025227
44MP0005397_hematopoietic_system_phenotyp1.40686024
45MP0001545_abnormal_hematopoietic_system1.40686024
46MP0000689_abnormal_spleen_morphology1.39686711
47MP0002138_abnormal_hepatobiliary_system1.38920567
48MP0004808_abnormal_hematopoietic_stem1.36943159
49MP0005076_abnormal_cell_differentiation1.36041243
50MP0000015_abnormal_ear_pigmentation1.34446163
51MP0001853_heart_inflammation1.32739705
52MP0005645_abnormal_hypothalamus_physiol1.32009620
53MP0003221_abnormal_cardiomyocyte_apopto1.31700624
54MP0004957_abnormal_blastocyst_morpholog1.28030213
55MP0002429_abnormal_blood_cell1.26515525
56MP0004510_myositis1.26433235
57MP0002722_abnormal_immune_system1.24864741
58MP0003724_increased_susceptibility_to1.24693194
59MP0008260_abnormal_autophagy1.23505749
60MP0005408_hypopigmentation1.22892218
61MP0003300_gastrointestinal_ulcer1.22298759
62MP0003718_maternal_effect1.22191389
63MP0006082_CNS_inflammation1.19628324
64MP0004947_skin_inflammation1.19174006
65MP0000490_abnormal_crypts_of1.18906666
66MP0008877_abnormal_DNA_methylation1.17761596
67MP0005464_abnormal_platelet_physiology1.16959953
68MP0001845_abnormal_inflammatory_respons1.14968092
69MP0000350_abnormal_cell_proliferation1.14783742
70MP0003195_calcinosis1.14036452
71MP0004782_abnormal_surfactant_physiolog1.10450758
72MP0002019_abnormal_tumor_incidence1.10243454
73MP0003252_abnormal_bile_duct1.07516016
74MP0010155_abnormal_intestine_physiology1.05083735
75MP0003303_peritoneal_inflammation1.04880763
76MP0000627_abnormal_mammary_gland1.04766428
77MP0006292_abnormal_olfactory_placode1.04389687
78MP0001348_abnormal_lacrimal_gland1.04025501
79MP0003786_premature_aging1.03659326
80MP0005171_absent_coat_pigmentation1.00796866
81MP0000703_abnormal_thymus_morphology1.00445849
82MP0010234_abnormal_vibrissa_follicle1.00295763
83MP0001533_abnormal_skeleton_physiology0.98903536
84MP0001119_abnormal_female_reproductive0.97872880
85MP0004484_altered_response_of0.97607424
86MP0003866_abnormal_defecation0.97376727
87MP0003191_abnormal_cellular_cholesterol0.96766196
88MP0000858_altered_metastatic_potential0.94746851
89MP0004883_abnormal_blood_vessel0.92323561
90MP0004381_abnormal_hair_follicle0.92289488
91MP0005167_abnormal_blood-brain_barrier0.91781659
92MP0010352_gastrointestinal_tract_polyps0.91708221
93MP0003828_pulmonary_edema0.91644332
94MP0001851_eye_inflammation0.91349347
95MP0006054_spinal_hemorrhage0.90032908
96MP0003453_abnormal_keratinocyte_physiol0.88810777
97MP0003950_abnormal_plasma_membrane0.88701627
98MP0002933_joint_inflammation0.86114512
99MP0000372_irregular_coat_pigmentation0.84915791
100MP0005379_endocrine/exocrine_gland_phen0.84613242
101MP0005174_abnormal_tail_pigmentation0.83588980
102MP0005075_abnormal_melanosome_morpholog0.83490024
103MP0001873_stomach_inflammation0.83354311
104MP0009764_decreased_sensitivity_to0.82864441
105MP0003091_abnormal_cell_migration0.82795002
106MP0003787_abnormal_imprinting0.82324295
107MP0000767_abnormal_smooth_muscle0.81078741
108MP0000313_abnormal_cell_death0.80941413
109MP0000371_diluted_coat_color0.80018998
110MP0001881_abnormal_mammary_gland0.76610191
111MP0002234_abnormal_pharynx_morphology0.75914696
112MP0002998_abnormal_bone_remodeling0.74912659
113MP0008932_abnormal_embryonic_tissue0.73948106
114MP0009763_increased_sensitivity_to0.73371019
115MP0001186_pigmentation_phenotype0.72625625
116MP0005621_abnormal_cell_physiology0.71920682
117MP0005380_embryogenesis_phenotype0.71580298
118MP0001672_abnormal_embryogenesis/_devel0.71580298
119MP0008469_abnormal_protein_level0.71320337
120MP0000383_abnormal_hair_follicle0.71080211
121MP0010678_abnormal_skin_adnexa0.68820326
122MP0002095_abnormal_skin_pigmentation0.68475840
123MP0009697_abnormal_copulation0.66990748
124MP0003690_abnormal_glial_cell0.66437852
125MP0002693_abnormal_pancreas_physiology0.62773210
126MP0008873_increased_physiological_sensi0.61901975
127MP0003075_altered_response_to0.59408908
128MP0003045_fibrosis0.59276093
129MP0000920_abnormal_myelination0.58153977
130MP0009115_abnormal_fat_cell0.56071336
131MP0005164_abnormal_response_to0.51134814
132MP0008789_abnormal_olfactory_epithelium0.51094114

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.90677233
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.83330681
3Recurrent abscess formation (HP:0002722)4.12005767
4Prostate neoplasm (HP:0100787)4.09549278
5Recurrent bacterial skin infections (HP:0005406)3.88551745
6Eczematoid dermatitis (HP:0000976)3.52206724
7Abnormality of the fingertips (HP:0001211)3.48655089
8Autoimmune thrombocytopenia (HP:0001973)3.39328283
9Optic neuritis (HP:0100653)3.38642889
10Retrobulbar optic neuritis (HP:0100654)3.38642889
11Birth length less than 3rd percentile (HP:0003561)3.37364466
12Myositis (HP:0100614)3.04897127
13Orchitis (HP:0100796)2.98490793
14Mediastinal lymphadenopathy (HP:0100721)2.95022580
15Abnormality of T cells (HP:0002843)2.89316790
16Abnormality of the prostate (HP:0008775)2.89166084
17Abnormality of B cell number (HP:0010975)2.87046731
18Albinism (HP:0001022)2.87002942
19Abnormality of chromosome stability (HP:0003220)2.84006846
20Panhypogammaglobulinemia (HP:0003139)2.83957664
21Acute myeloid leukemia (HP:0004808)2.83192448
22B lymphocytopenia (HP:0010976)2.80705365
23Elevated erythrocyte sedimentation rate (HP:0003565)2.79787434
24Fatigue (HP:0012378)2.75933213
25Exertional dyspnea (HP:0002875)2.73110600
26Reduced antithrombin III activity (HP:0001976)2.72239726
27Capillary hemangiomas (HP:0005306)2.69743261
28Chronic diarrhea (HP:0002028)2.69050376
29Recurrent viral infections (HP:0004429)2.63594340
30Chronic obstructive pulmonary disease (HP:0006510)2.62326236
31Obstructive lung disease (HP:0006536)2.62326236
32Autoimmune hemolytic anemia (HP:0001890)2.62037584
33Severe combined immunodeficiency (HP:0004430)2.61385538
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.61162424
35Clubbing of toes (HP:0100760)2.60779891
36Meckel diverticulum (HP:0002245)2.60188022
37Chest pain (HP:0100749)2.59041002
38Subacute progressive viral hepatitis (HP:0006572)2.57794950
39Eosinophilia (HP:0001880)2.57681062
40Recurrent fungal infections (HP:0002841)2.57299491
41Leukocytosis (HP:0001974)2.52600069
42Abnormality of T cell physiology (HP:0011840)2.51600921
43Ectopic kidney (HP:0000086)2.50705825
44Keratoconjunctivitis sicca (HP:0001097)2.49414087
45Neoplasm of the tracheobronchial system (HP:0100552)2.49148942
46Gastrointestinal infarctions (HP:0005244)2.47433022
47Recurrent gram-negative bacterial infections (HP:0005420)2.46920716
48Vasculitis (HP:0002633)2.45455214
49Increased IgM level (HP:0003496)2.45412949
50Papillary thyroid carcinoma (HP:0002895)2.40524894
51Abnormality of the ileum (HP:0001549)2.40285447
52Spontaneous hematomas (HP:0007420)2.39135846
53Pustule (HP:0200039)2.37288318
54Flat capital femoral epiphysis (HP:0003370)2.36606315
55Prolonged bleeding time (HP:0003010)2.36510753
56Arterial thrombosis (HP:0004420)2.36060886
57Pulmonary embolism (HP:0002204)2.34900737
58Granulocytopenia (HP:0001913)2.34285020
59Gingivitis (HP:0000230)2.33867803
60Abnormality of the preputium (HP:0100587)2.33008005
61Myocardial infarction (HP:0001658)2.31830402
62Recurrent skin infections (HP:0001581)2.30002878
63Stomatitis (HP:0010280)2.29684142
64Fair hair (HP:0002286)2.29583483
65Gangrene (HP:0100758)2.26683807
66Patellar aplasia (HP:0006443)2.25812339
67Keratoconjunctivitis (HP:0001096)2.25357619
68Urticaria (HP:0001025)2.24725532
69Myelodysplasia (HP:0002863)2.23736578
70Stomach cancer (HP:0012126)2.22909407
71Recurrent pneumonia (HP:0006532)2.22191502
72Abnormality of macrophages (HP:0004311)2.17716516
73Abnormality of male internal genitalia (HP:0000022)2.16878306
74Epistaxis (HP:0000421)2.15973997
75Slender build (HP:0001533)2.15156573
76Pulmonary infiltrates (HP:0002113)2.14630425
77Abnormality of T cell number (HP:0011839)2.13949929
78Spinal cord lesions (HP:0100561)2.13296913
79Syringomyelia (HP:0003396)2.13296913
80Viral hepatitis (HP:0006562)2.13281896
81Meningitis (HP:0001287)2.12181900
82Combined immunodeficiency (HP:0005387)2.12133969
83Hematochezia (HP:0002573)2.11389004
84Generalized hypopigmentation of hair (HP:0011358)2.10888181
85Abnormality of the columella (HP:0009929)2.10136564
86Thrombocytosis (HP:0001894)2.08302703
87Thyroid carcinoma (HP:0002890)2.07618646
88Anorexia (HP:0002039)2.06899819
89Alveolar cell carcinoma (HP:0006519)2.06398756
90Basal ganglia calcification (HP:0002135)2.06264724
91Thick nail (HP:0001805)2.05874034
92Abnormality of eosinophils (HP:0001879)2.05508145
93Hypochromic microcytic anemia (HP:0004840)2.04703371
94Hypoplasia of the thymus (HP:0000778)2.04336743
95Osteolytic defects of the phalanges of the hand (HP:0009771)2.01774049
96Osteolytic defects of the hand bones (HP:0009699)2.01774049
97Absent frontal sinuses (HP:0002688)2.01231877
98Biliary tract neoplasm (HP:0100574)2.00645150
99Aplasia/Hypoplasia of the patella (HP:0006498)1.98514519
100Thrombophlebitis (HP:0004418)1.93594625
101Thyroiditis (HP:0100646)1.93347129
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.92011621
103Encephalitis (HP:0002383)1.91873137
104Periodontitis (HP:0000704)1.91427681
105Amaurosis fugax (HP:0100576)1.91100071
106IgG deficiency (HP:0004315)1.90979405
107Breast hypoplasia (HP:0003187)1.89029030
108Abnormality of the pleura (HP:0002103)1.88859470
109Recurrent lower respiratory tract infections (HP:0002783)1.88826931
110Neoplasm of the adrenal cortex (HP:0100641)1.88457064
111Agnosia (HP:0010524)1.85758884
112IgM deficiency (HP:0002850)1.85713553
113Joint swelling (HP:0001386)1.84499369
114Lymphoma (HP:0002665)1.84030354
115Osteomyelitis (HP:0002754)1.83051458
116Type I transferrin isoform profile (HP:0003642)1.82853827
117Azoospermia (HP:0000027)1.82421606
118Prominent metopic ridge (HP:0005487)1.81907640
119Bone marrow hypocellularity (HP:0005528)1.81811556
120Cellulitis (HP:0100658)1.81549155
121Gingival bleeding (HP:0000225)1.81190021
122Dyschromatopsia (HP:0007641)1.80638190
123Ocular albinism (HP:0001107)1.80510298
124IgA deficiency (HP:0002720)1.78857273
125Curly hair (HP:0002212)1.78209019
126Pulmonary fibrosis (HP:0002206)1.77833601
127Abnormality of incisor morphology (HP:0011063)1.77596048
128T lymphocytopenia (HP:0005403)1.77276737
129Recurrent cutaneous fungal infections (HP:0011370)1.77201882
130Chronic mucocutaneous candidiasis (HP:0002728)1.77201882
131Small intestinal stenosis (HP:0012848)1.76848652
132Duodenal stenosis (HP:0100867)1.76848652
133Tented upper lip vermilion (HP:0010804)1.76315477
134Polyneuropathy (HP:0001271)1.76021045
135Lymphopenia (HP:0001888)1.75709943
136Hypothermia (HP:0002045)1.75504917
137Recurrent bronchitis (HP:0002837)1.75440766
138Abnormal spermatogenesis (HP:0008669)1.75222572
139Duplicated collecting system (HP:0000081)1.72480008
140Volvulus (HP:0002580)1.72048884
141Constricted visual fields (HP:0001133)1.71508492
142Episodic fever (HP:0001954)1.70393210
143Leukopenia (HP:0001882)1.70158361
144Hemoptysis (HP:0002105)1.69697251
145Weight loss (HP:0001824)1.69152951
146Keratitis (HP:0000491)1.68456898
147Ectropion (HP:0000656)1.67220690
148Abnormality of chromosome segregation (HP:0002916)1.65168551
149Hypoproteinemia (HP:0003075)1.64600479
150Irregular epiphyses (HP:0010582)1.64376842
151Stillbirth (HP:0003826)1.62330865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.92797225
2LATS13.20627696
3BRSK23.16130362
4IRAK32.82516374
5IRAK42.81834483
6TRIM282.79505505
7MKNK22.42437108
8CDC72.33461082
9PRPF4B2.31000536
10TXK2.24172031
11JAK32.18406101
12SRPK12.08013747
13TNIK2.07873893
14IKBKB1.95075157
15PIK3CG1.91444452
16CDK121.85035699
17EPHA31.81936923
18STK31.81136423
19NUAK11.81054172
20STK38L1.80991368
21PLK41.76622615
22TYK21.73386969
23SIK31.71991028
24CHUK1.69946383
25IKBKE1.66788147
26MKNK11.65744845
27ZAK1.65604475
28PIM11.57617090
29TRPM71.53308656
30BRD41.50013300
31MAP4K11.46967786
32FES1.46959102
33ACVR1B1.33719468
34EIF2AK21.32522519
35MARK31.32185227
36EIF2AK11.31541243
37STK41.30975778
38FGR1.28652137
39ITK1.27043461
40CHEK21.21375985
41STK101.17912978
42NEK21.14968978
43STK241.14945333
44TTK1.14181633
45JAK11.12361831
46RPS6KA41.12243918
47CLK11.10427203
48NEK91.09964804
49TEC1.08359010
50FGFR31.06387136
51IRAK11.01418254
52TBK11.00608745
53PLK11.00015550
54PLK20.97774697
55PLK30.97213711
56WEE10.95216866
57ERBB40.95170266
58BRSK10.94662623
59FRK0.93907668
60EIF2AK30.93867476
61MAPK130.92255695
62VRK10.90644028
63MAP3K130.90234143
64YES10.90184301
65NEK60.87753049
66ATR0.86681701
67IRAK20.86069239
68MST40.85472527
69BMPR20.84661354
70CSK0.82836265
71CHEK10.82041873
72MAP3K20.81521009
73AURKB0.79713329
74ABL20.79602190
75ATM0.79154842
76MAP3K60.78341334
77PTK2B0.78318042
78SGK20.77057281
79ZAP700.75666878
80KIT0.75455823
81MAP3K120.74813395
82CDK40.72895203
83LYN0.72583482
84EGFR0.70454763
85NLK0.68125111
86MELK0.66402849
87CDK90.66052806
88HCK0.65818797
89BTK0.65035999
90TAOK20.64897817
91DYRK30.64749732
92PBK0.62956294
93ABL10.62580808
94LCK0.62489783
95CDK30.62420058
96CASK0.61379473
97CSF1R0.60803811
98TAOK30.59642247
99OXSR10.59420046
100RIPK40.58604726
101MATK0.58133494
102CDK70.58071139
103TGFBR20.56880214
104MAP4K20.56604448
105TSSK60.56225337
106SGK30.55909154
107CDK60.55605742
108LATS20.55205867
109CAMKK20.54638917
110BLK0.54311984
111WNK30.53179257
112HIPK20.51826406
113MAP2K30.50984875
114TNK20.50388268
115MAP3K80.50156573
116BMPR1B0.48645822
117SYK0.48037714
118GRK60.47201946
119BCR0.46886712
120RPS6KA50.45532190
121PIM20.44367296
122JAK20.43148184
123PRKCQ0.42401763
124KSR10.42179368
125FGFR20.41616289
126ERBB30.41079851
127MAPK110.40899041
128IGF1R0.40421484
129PRKAA20.40261277
130AKT30.40057798
131MAP3K40.39542403
132PKN10.38142462
133RAF10.37696954
134PAK30.37148519
135GRK10.35396121

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.59812771
2Allograft rejection_Homo sapiens_hsa053302.45666466
3Graft-versus-host disease_Homo sapiens_hsa053322.45326666
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16690725
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.16363155
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.11243764
7Leishmaniasis_Homo sapiens_hsa051402.07526206
8Measles_Homo sapiens_hsa051622.03969404
9Fanconi anemia pathway_Homo sapiens_hsa034601.98183328
10Herpes simplex infection_Homo sapiens_hsa051681.97713327
11Homologous recombination_Homo sapiens_hsa034401.93160316
12Cell cycle_Homo sapiens_hsa041101.89824209
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88850833
14Autoimmune thyroid disease_Homo sapiens_hsa053201.84514139
15DNA replication_Homo sapiens_hsa030301.72708281
16p53 signaling pathway_Homo sapiens_hsa041151.71262250
17Influenza A_Homo sapiens_hsa051641.63672361
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60269105
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59611330
20Basal transcription factors_Homo sapiens_hsa030221.57669992
21Mismatch repair_Homo sapiens_hsa034301.48748438
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46875239
23Primary immunodeficiency_Homo sapiens_hsa053401.44638869
24RNA polymerase_Homo sapiens_hsa030201.43988082
25Non-homologous end-joining_Homo sapiens_hsa034501.43594384
26Base excision repair_Homo sapiens_hsa034101.43338547
27TNF signaling pathway_Homo sapiens_hsa046681.43257124
28Osteoclast differentiation_Homo sapiens_hsa043801.42019076
29Asthma_Homo sapiens_hsa053101.41172225
30Staphylococcus aureus infection_Homo sapiens_hsa051501.39586950
31Apoptosis_Homo sapiens_hsa042101.32649362
32Hematopoietic cell lineage_Homo sapiens_hsa046401.30430308
33RNA degradation_Homo sapiens_hsa030181.27986673
34Malaria_Homo sapiens_hsa051441.26444974
35RNA transport_Homo sapiens_hsa030131.23921856
36One carbon pool by folate_Homo sapiens_hsa006701.23717055
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.23256040
38Antigen processing and presentation_Homo sapiens_hsa046121.22238636
39Legionellosis_Homo sapiens_hsa051341.21877849
40Dorso-ventral axis formation_Homo sapiens_hsa043201.20401317
41Type I diabetes mellitus_Homo sapiens_hsa049401.19652230
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19394871
43Hepatitis B_Homo sapiens_hsa051611.19246031
44Toxoplasmosis_Homo sapiens_hsa051451.19176422
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17523821
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15961205
47Tuberculosis_Homo sapiens_hsa051521.15818816
48Small cell lung cancer_Homo sapiens_hsa052221.15568972
49Chemokine signaling pathway_Homo sapiens_hsa040621.14770410
50MicroRNAs in cancer_Homo sapiens_hsa052061.14248385
51Epstein-Barr virus infection_Homo sapiens_hsa051691.14111640
52mRNA surveillance pathway_Homo sapiens_hsa030151.13092607
53Regulation of autophagy_Homo sapiens_hsa041401.12453500
54Spliceosome_Homo sapiens_hsa030401.10955860
55Shigellosis_Homo sapiens_hsa051311.08197133
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06489890
57Pertussis_Homo sapiens_hsa051331.05616633
58Viral myocarditis_Homo sapiens_hsa054161.05473654
59Pancreatic cancer_Homo sapiens_hsa052120.99322368
60Vitamin B6 metabolism_Homo sapiens_hsa007500.99119371
61B cell receptor signaling pathway_Homo sapiens_hsa046620.98834542
62T cell receptor signaling pathway_Homo sapiens_hsa046600.98600804
63Nucleotide excision repair_Homo sapiens_hsa034200.97562108
64Viral carcinogenesis_Homo sapiens_hsa052030.97557863
65Protein export_Homo sapiens_hsa030600.96879493
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96087082
67HTLV-I infection_Homo sapiens_hsa051660.90622408
68Salmonella infection_Homo sapiens_hsa051320.87705444
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81868612
70TGF-beta signaling pathway_Homo sapiens_hsa043500.81535145
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76545863
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76497413
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76175225
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.74966510
75Systemic lupus erythematosus_Homo sapiens_hsa053220.74578893
76Ether lipid metabolism_Homo sapiens_hsa005650.71802813
77Rheumatoid arthritis_Homo sapiens_hsa053230.70775035
78Chronic myeloid leukemia_Homo sapiens_hsa052200.68860404
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68148276
80Pyrimidine metabolism_Homo sapiens_hsa002400.67992319
81Prostate cancer_Homo sapiens_hsa052150.67551699
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.66621344
83Hepatitis C_Homo sapiens_hsa051600.65578482
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.65096788
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64071673
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63623700
87Adherens junction_Homo sapiens_hsa045200.63549571
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62773470
89Renal cell carcinoma_Homo sapiens_hsa052110.62050465
90Acute myeloid leukemia_Homo sapiens_hsa052210.59249989
91African trypanosomiasis_Homo sapiens_hsa051430.58212602
92Inositol phosphate metabolism_Homo sapiens_hsa005620.56879449
93FoxO signaling pathway_Homo sapiens_hsa040680.55566040
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55375258
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55130426
96Prolactin signaling pathway_Homo sapiens_hsa049170.54343178
97Glioma_Homo sapiens_hsa052140.51197490
98mTOR signaling pathway_Homo sapiens_hsa041500.50003450
99Notch signaling pathway_Homo sapiens_hsa043300.48703809
100Thyroid cancer_Homo sapiens_hsa052160.48577362
101Colorectal cancer_Homo sapiens_hsa052100.46370441
102Sphingolipid metabolism_Homo sapiens_hsa006000.44381071
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44314138
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43630585
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.42940899
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42885068
107Endometrial cancer_Homo sapiens_hsa052130.42657984
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41701888
109Pathways in cancer_Homo sapiens_hsa052000.40701181
110Phagosome_Homo sapiens_hsa041450.40338920
111Platelet activation_Homo sapiens_hsa046110.40082699
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39839368
113Non-small cell lung cancer_Homo sapiens_hsa052230.39504961
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38821383
115Insulin resistance_Homo sapiens_hsa049310.35960111
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35645873
117Selenocompound metabolism_Homo sapiens_hsa004500.35526205
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35525264
119Circadian rhythm_Homo sapiens_hsa047100.34030902
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33773373
121Glycerolipid metabolism_Homo sapiens_hsa005610.33429378
122Other glycan degradation_Homo sapiens_hsa005110.32489901
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31421748
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31417910
125Type II diabetes mellitus_Homo sapiens_hsa049300.30200525
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.28817819

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