FOXN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.99822232
2axon ensheathment in central nervous system (GO:0032291)9.99822232
3fatty acid elongation (GO:0030497)6.86740726
4long-chain fatty acid biosynthetic process (GO:0042759)6.57716640
5myelination (GO:0042552)6.21009121
6ensheathment of neurons (GO:0007272)6.18136369
7axon ensheathment (GO:0008366)6.18136369
8negative regulation of neurotransmitter secretion (GO:0046929)5.70178903
9negative regulation of protein localization to cell surface (GO:2000009)4.96201974
10negative regulation of neurotransmitter transport (GO:0051589)4.68240614
11oligodendrocyte differentiation (GO:0048709)4.54925294
12presynaptic membrane organization (GO:0097090)4.52145353
13limb bud formation (GO:0060174)4.46341959
14positive regulation of gamma-delta T cell activation (GO:0046645)4.45947955
15presynaptic membrane assembly (GO:0097105)4.42570854
16cerebral cortex radially oriented cell migration (GO:0021799)4.33078486
17glycerophospholipid catabolic process (GO:0046475)4.29173809
18histone H3-K36 demethylation (GO:0070544)4.23899110
19myelination in peripheral nervous system (GO:0022011)4.15668392
20peripheral nervous system axon ensheathment (GO:0032292)4.15668392
21photoreceptor cell differentiation (GO:0046530)4.11145468
22eye photoreceptor cell differentiation (GO:0001754)4.11145468
23regulation of gamma-delta T cell differentiation (GO:0045586)3.94437227
24cholesterol biosynthetic process (GO:0006695)3.94244159
25astrocyte development (GO:0014002)3.90484876
26myelin maintenance (GO:0043217)3.89305748
27regulation of collateral sprouting (GO:0048670)3.86271457
28regulation of gamma-delta T cell activation (GO:0046643)3.78781384
29response to redox state (GO:0051775)3.77595567
30GPI anchor biosynthetic process (GO:0006506)3.74079415
31GPI anchor metabolic process (GO:0006505)3.67410075
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.64975148
33negative regulation of cell killing (GO:0031342)3.64975148
34myofibril assembly (GO:0030239)3.62367115
35isoprenoid biosynthetic process (GO:0008299)3.62269850
36virion attachment to host cell (GO:0019062)3.52133986
37adhesion of symbiont to host cell (GO:0044650)3.52133986
38positive regulation of action potential (GO:0045760)3.50337063
39regulation of B cell receptor signaling pathway (GO:0050855)3.49201694
40negative regulation of execution phase of apoptosis (GO:1900118)3.46773022
41negative regulation of myoblast differentiation (GO:0045662)3.45124794
42negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.43573084
43sterol biosynthetic process (GO:0016126)3.42124828
44mannosylation (GO:0097502)3.42037990
45preassembly of GPI anchor in ER membrane (GO:0016254)3.39598959
46muscle filament sliding (GO:0030049)3.38021809
47actin-myosin filament sliding (GO:0033275)3.38021809
48negative regulation of JUN kinase activity (GO:0043508)3.32574739
49import into cell (GO:0098657)3.22283330
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20073821
51regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.18244335
52lateral sprouting from an epithelium (GO:0060601)3.17564135
53cranial nerve development (GO:0021545)3.17463531
54positive regulation of oligodendrocyte differentiation (GO:0048714)3.17064767
55cardiac myofibril assembly (GO:0055003)3.15694597
56cellular extravasation (GO:0045123)3.14110394
57amyloid precursor protein metabolic process (GO:0042982)3.13417479
58sarcoplasmic reticulum calcium ion transport (GO:0070296)3.12722230
59response to lipoprotein particle (GO:0055094)3.11836938
60nucleotide transmembrane transport (GO:1901679)3.07995650
61B cell receptor signaling pathway (GO:0050853)3.06065112
62negative thymic T cell selection (GO:0045060)3.03368365
63L-amino acid import (GO:0043092)3.03332479
64negative T cell selection (GO:0043383)3.03151317
65negative regulation of erythrocyte differentiation (GO:0045647)3.02901019
66peripheral nervous system development (GO:0007422)2.98738024
67asymmetric protein localization (GO:0008105)2.97841208
68actin-mediated cell contraction (GO:0070252)2.96895414
69peptidyl-tyrosine autophosphorylation (GO:0038083)2.94684357
70ear development (GO:0043583)2.93294341
71establishment of mitochondrion localization (GO:0051654)2.92057572
72positive T cell selection (GO:0043368)2.90489546
73substantia nigra development (GO:0021762)2.90329404
74cardiac muscle hypertrophy (GO:0003300)2.89722614
75creatine metabolic process (GO:0006600)2.88723962
76positive thymic T cell selection (GO:0045059)2.87384480
77regulation of translation, ncRNA-mediated (GO:0045974)2.84244091
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.84244091
79negative regulation of translation, ncRNA-mediated (GO:0040033)2.84244091
80response to interleukin-15 (GO:0070672)2.80392243
81apical protein localization (GO:0045176)2.78168191
82positive regulation of actin filament depolymerization (GO:0030836)2.77018465
83striated muscle hypertrophy (GO:0014897)2.75777402
84magnesium ion transport (GO:0015693)2.75288302
85cardiac muscle hypertrophy in response to stress (GO:0014898)2.73962603
86muscle hypertrophy in response to stress (GO:0003299)2.73962603
87cardiac muscle adaptation (GO:0014887)2.73962603
88organ growth (GO:0035265)2.73679533
89protein palmitoylation (GO:0018345)2.72160426
90actin filament-based movement (GO:0030048)2.71770651
91interleukin-6-mediated signaling pathway (GO:0070102)2.71635948
92skeletal muscle contraction (GO:0003009)2.70336599
93negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.69713335
94detection of other organism (GO:0098543)2.68999971
95glial cell development (GO:0021782)2.67960941
96regulation of gene silencing by RNA (GO:0060966)2.67096796
97regulation of posttranscriptional gene silencing (GO:0060147)2.67096796
98regulation of gene silencing by miRNA (GO:0060964)2.67096796
99positive regulation of Rap GTPase activity (GO:0032854)2.65662593
100response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.64665569
101otic vesicle formation (GO:0030916)2.64093715
102regulation of skeletal muscle contraction (GO:0014819)2.62185287
103modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62059482
104modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62059482
105positive regulation by organism of defense response of other organism involved in symbiotic interact2.62059482
106modulation by symbiont of host immune response (GO:0052553)2.62059482
107positive regulation by symbiont of host defense response (GO:0052509)2.62059482
108modulation by symbiont of host defense response (GO:0052031)2.62059482
109regulation of pigment cell differentiation (GO:0050932)2.61992441
110positive regulation of cell fate commitment (GO:0010455)2.60813268
111striated muscle adaptation (GO:0014888)2.59142633
112negative regulation of T cell mediated immunity (GO:0002710)2.58784771
113long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.58280827
114muscle hypertrophy (GO:0014896)2.57240360
115long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.56303328
116T cell selection (GO:0045058)2.55714742
117embryonic process involved in female pregnancy (GO:0060136)2.55048572
118membrane assembly (GO:0071709)2.54884254
119activated T cell proliferation (GO:0050798)2.54722347
120positive regulation of granulocyte differentiation (GO:0030854)2.54719155
121adhesion of symbiont to host (GO:0044406)2.54507443
122positive regulation of B cell differentiation (GO:0045579)2.53296157
123positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53087456
124detection of molecule of bacterial origin (GO:0032490)2.53071231
125sphingoid metabolic process (GO:0046519)2.52562280
126amyloid precursor protein catabolic process (GO:0042987)2.52416677
127germinal center formation (GO:0002467)2.52182557
128axon development (GO:0061564)2.51717321
129regulation of B cell differentiation (GO:0045577)2.51629044
130microtubule polymerization or depolymerization (GO:0031109)2.51453258
131detection of bacterium (GO:0016045)2.50540818
132leukocyte migration involved in inflammatory response (GO:0002523)2.49764219
133glycosylceramide metabolic process (GO:0006677)2.49638563
134regulation of tolerance induction (GO:0002643)2.48980081
135interkinetic nuclear migration (GO:0022027)2.47759917
136glial cell differentiation (GO:0010001)2.47403191
137neuron remodeling (GO:0016322)2.45924226
138regulation of cell proliferation involved in kidney development (GO:1901722)2.45742643
139positive regulation of interleukin-17 production (GO:0032740)2.44935794
140protein K63-linked deubiquitination (GO:0070536)2.44742049
141adult walking behavior (GO:0007628)2.44713331
142detection of external biotic stimulus (GO:0098581)2.44443217
143mesenchymal cell differentiation involved in renal system development (GO:2001012)2.44383633
144mesenchymal cell differentiation involved in kidney development (GO:0072161)2.44383633
145antigen processing and presentation of endogenous antigen (GO:0019883)2.43843921
146mannose metabolic process (GO:0006013)2.43175715
147ceramide biosynthetic process (GO:0046513)2.42989908
148positive regulation of myoblast differentiation (GO:0045663)2.42906476
149response to inactivity (GO:0014854)2.42764338
150positive regulation of cellular amine metabolic process (GO:0033240)2.42670061
151phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42349245
152cellular response to epinephrine stimulus (GO:0071872)2.42089037
153regulation of relaxation of muscle (GO:1901077)2.41805701
154negative regulation of stem cell proliferation (GO:2000647)2.41649586
155negative regulation of lymphocyte mediated immunity (GO:0002707)2.40755444
156cytoplasmic mRNA processing body assembly (GO:0033962)2.40533840
157regulation of platelet aggregation (GO:0090330)2.40466335
158cellular response to gamma radiation (GO:0071480)2.39733518
159negative regulation of axon extension (GO:0030517)2.39561546
160negative regulation of axonogenesis (GO:0050771)2.39367831
161C-terminal protein lipidation (GO:0006501)2.39048717
162response to muscle activity (GO:0014850)2.39040289
163skeletal muscle adaptation (GO:0043501)2.39035025
164myelin assembly (GO:0032288)2.38628617
165glycolipid biosynthetic process (GO:0009247)2.38422751
166antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37822490
167positive regulation of smooth muscle cell migration (GO:0014911)2.37337740
168negative regulation of axon extension involved in axon guidance (GO:0048843)2.36470237
169regulation of granulocyte differentiation (GO:0030852)2.35997070
170regulation of necroptotic process (GO:0060544)2.35865267
171positive regulation of glial cell differentiation (GO:0045687)2.35816212
172regulation of T cell tolerance induction (GO:0002664)2.35629115
173Peyers patch development (GO:0048541)2.35203603
174mucosal-associated lymphoid tissue development (GO:0048537)2.35203603
175positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34949075
176thymic T cell selection (GO:0045061)2.34566184
177regulation of germinal center formation (GO:0002634)2.34147017
178negative regulation of granulocyte differentiation (GO:0030853)2.33957285
179mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.33852922
180positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.33852922
181regulation of sarcomere organization (GO:0060297)2.33601020
182cellular response to hepatocyte growth factor stimulus (GO:0035729)2.33510622
183response to hepatocyte growth factor (GO:0035728)2.33510622
184adult heart development (GO:0007512)2.32707188
185carnitine shuttle (GO:0006853)2.32172663
186B cell homeostasis (GO:0001782)2.31454479
187positive regulation of myotube differentiation (GO:0010831)2.30685723
188response to epinephrine (GO:0071871)2.30182487
189detection of biotic stimulus (GO:0009595)2.29851370
190negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.29188690
191negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.28530419
192negative regulation of T-helper cell differentiation (GO:0045623)2.28530419
193regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.28172959
194definitive hemopoiesis (GO:0060216)2.26997414
195pre-miRNA processing (GO:0031054)2.26786272
196cellular response to osmotic stress (GO:0071470)2.26607899
197cellular response to fluid shear stress (GO:0071498)2.23381378
198regulation of apoptotic cell clearance (GO:2000425)2.22920337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.59005070
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.41702556
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.94724353
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.87769087
5TAF15_26573619_Chip-Seq_HEK293_Human2.82750273
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72299667
7* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64716403
8* RUNX_20019798_ChIP-Seq_JUKART_Human2.64279064
9* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.51462477
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46792770
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13198566
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09949294
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09014367
14GATA1_22025678_ChIP-Seq_K562_Human2.05774240
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05012810
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02443890
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.01637372
18OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.01233236
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99404104
20SCL_19346495_ChIP-Seq_HPC-7_Human1.96410928
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95204103
22* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.94059666
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.80911434
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78882745
25* VDR_24787735_ChIP-Seq_THP-1_Human1.78601112
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.78003643
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76630254
28P300_19829295_ChIP-Seq_ESCs_Human1.76196119
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75989910
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75831941
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75642250
32FUS_26573619_Chip-Seq_HEK293_Human1.74074899
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71504797
34* ER_23166858_ChIP-Seq_MCF-7_Human1.71061089
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69733231
36IRF1_19129219_ChIP-ChIP_H3396_Human1.68795524
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68436904
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67530892
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.67456791
40VDR_22108803_ChIP-Seq_LS180_Human1.66947144
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65409323
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.65327495
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65147901
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61582036
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60941167
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.59781011
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59609916
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.58034574
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.57307139
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.56956256
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55952615
52* PIAS1_25552417_ChIP-Seq_VCAP_Human1.55636253
53SUZ12_18555785_Chip-Seq_ESCs_Mouse1.55553467
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54552213
55TCF7_22412390_ChIP-Seq_EML_Mouse1.53516533
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.52463868
57RNF2_27304074_Chip-Seq_NSC_Mouse1.52403112
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50683880
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49473066
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49171974
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49161097
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48751418
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.47584281
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47140397
65* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46100563
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45878699
67MYC_22102868_ChIP-Seq_BL_Human1.45218465
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44893709
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44489588
70* FOXA2_19822575_ChIP-Seq_HepG2_Human1.44020661
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42963587
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42963587
73P300_18555785_Chip-Seq_ESCs_Mouse1.41332790
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.41191109
75AR_21572438_ChIP-Seq_LNCaP_Human1.41101752
76* LXR_22158963_ChIP-Seq_LIVER_Mouse1.40546183
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40351713
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.40126053
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39148054
80MYB_26560356_Chip-Seq_TH2_Human1.39132485
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38420915
82* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38066267
83EZH2_22144423_ChIP-Seq_EOC_Human1.37969658
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.37388122
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37103564
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36938989
87* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36888253
88* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36819232
89DROSHA_22980978_ChIP-Seq_HELA_Human1.36271790
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.36186018
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.34923825
92P53_22387025_ChIP-Seq_ESCs_Mouse1.34806484
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34181090
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33482764
95EWS_26573619_Chip-Seq_HEK293_Human1.32816767
96* VDR_24763502_ChIP-Seq_THP-1_Human1.32570795
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32040389
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32040389
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32040389
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.31986017
101* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30401396
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.29348873
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28678354
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27867372
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27670939
106* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26126820
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25968413
108RUNX1_27457419_Chip-Seq_LIVER_Mouse1.24468300
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.23539381
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.23307150
111KDM2B_26808549_Chip-Seq_DND41_Human1.23219274
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23201434
113TBX20_22328084_ChIP-Seq_HEART_Mouse1.22962990
114TBX20_22080862_ChIP-Seq_HEART_Mouse1.22962990
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22255539
116* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21795098
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21743355
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21669274
119SPI1_23127762_ChIP-Seq_K562_Human1.21416125
120NMYC_18555785_Chip-Seq_ESCs_Mouse1.20365309
121MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20215506
122KLF4_18555785_Chip-Seq_ESCs_Mouse1.20030849
123SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19677454
124* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18845606
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16895519
126OCT4_18555785_Chip-Seq_ESCs_Mouse1.16629003
127* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16372727
128* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15760329
129ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15641974
130* STAT3_23295773_ChIP-Seq_U87_Human1.15249713
131BP1_19119308_ChIP-ChIP_Hs578T_Human1.15046507
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13826894
133* SMAD4_21799915_ChIP-Seq_A2780_Human1.12889843
134IGF1R_20145208_ChIP-Seq_DFB_Human1.12800841
135SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11903252
136MYB_26560356_Chip-Seq_TH1_Human1.11851015
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11485593
138NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10961383
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10961383
140NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10515867
141* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09423917
142ESR1_20079471_ChIP-ChIP_T-47D_Human1.09352387
143NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09352142
144* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.09157199
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08750053
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08750053
147PU1_27457419_Chip-Seq_LIVER_Mouse1.08456891
148CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08391912
149GATA3_27048872_Chip-Seq_THYMUS_Human1.08137024
150SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08014124
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06738291
152PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06389864
153* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04889410
154RXR_22108803_ChIP-Seq_LS180_Human1.04768934
155* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04389391
156GATA2_21666600_ChIP-Seq_HMVEC_Human1.02691412
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02615446
158FOXO3_23340844_ChIP-Seq_DLD1_Human1.01139467
159BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01123424
160MAF_26560356_Chip-Seq_TH1_Human1.00508268
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99195607
162PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98632917
163GATA1_19941826_ChIP-Seq_K562_Human0.97300333
164* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97088497
165* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95485307
166PU_27001747_Chip-Seq_BMDM_Mouse0.95192169
167* UTX_26944678_Chip-Seq_JUKART_Human0.92479189
168TCF4_18268006_ChIP-ChIP_LS174T_Human0.91987735
169SMAD3_21741376_ChIP-Seq_HESCs_Human0.91931809
170KDM2B_26808549_Chip-Seq_JURKAT_Human0.91525774
171EGR1_19374776_ChIP-ChIP_THP-1_Human0.91492578
172RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89681346
173CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89285849
174* AHR_22903824_ChIP-Seq_MCF-7_Human0.89104761
175HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88604197
176GF1_26923725_Chip-Seq_HPCs_Mouse0.86602062
177* ARNT_22903824_ChIP-Seq_MCF-7_Human0.86050567
178SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85928318
179RXR_22158963_ChIP-Seq_LIVER_Mouse0.85926643
180* VDR_21846776_ChIP-Seq_THP-1_Human0.85410301
181* GATA2_19941826_ChIP-Seq_K562_Human0.85174489
182SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84347949
183RUNX1_22412390_ChIP-Seq_EML_Mouse0.83679184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.77509864
2MP0004130_abnormal_muscle_cell3.43911970
3MP0003950_abnormal_plasma_membrane3.39627954
4MP0005171_absent_coat_pigmentation3.34737977
5MP0003136_yellow_coat_color3.29050919
6MP0005409_darkened_coat_color3.04376781
7MP0003646_muscle_fatigue2.84317220
8MP0000566_synostosis2.83905642
9MP0004381_abnormal_hair_follicle2.81001439
10MP0000751_myopathy2.78078343
11MP0003690_abnormal_glial_cell2.74443112
12MP0004036_abnormal_muscle_relaxation2.73060369
13MP0003828_pulmonary_edema2.63488778
14MP0004084_abnormal_cardiac_muscle2.60939353
15MP0003763_abnormal_thymus_physiology2.58341920
16MP0001529_abnormal_vocalization2.56404067
17MP0003880_abnormal_central_pattern2.39714619
18MP0001905_abnormal_dopamine_level2.37603230
19MP0001346_abnormal_lacrimal_gland2.30623149
20MP0000383_abnormal_hair_follicle2.29049504
21MP0004742_abnormal_vestibular_system2.28412233
22MP0005646_abnormal_pituitary_gland2.26278135
23MP0006292_abnormal_olfactory_placode2.25088718
24MP0004145_abnormal_muscle_electrophysio2.17789392
25MP0005451_abnormal_body_composition2.17615402
26MP0000778_abnormal_nervous_system2.16280337
27MP0002396_abnormal_hematopoietic_system2.13270300
28MP0000749_muscle_degeneration2.11026844
29MP0001188_hyperpigmentation2.10777622
30MP0004087_abnormal_muscle_fiber2.09905919
31MP0003303_peritoneal_inflammation2.07076103
32MP0004134_abnormal_chest_morphology2.06208806
33MP0005275_abnormal_skin_tensile2.04283841
34MP0001485_abnormal_pinna_reflex1.94326755
35MP0004270_analgesia1.94077678
36MP0006138_congestive_heart_failure1.93232352
37MP0004147_increased_porphyrin_level1.92661271
38MP0002106_abnormal_muscle_physiology1.92146476
39MP0005666_abnormal_adipose_tissue1.91596671
40MP0005670_abnormal_white_adipose1.91062137
41MP0003436_decreased_susceptibility_to1.90195032
42MP0001835_abnormal_antigen_presentation1.82967283
43MP0004185_abnormal_adipocyte_glucose1.82947693
44MP0002166_altered_tumor_susceptibility1.82615254
45MP0001486_abnormal_startle_reflex1.79283482
46MP0003634_abnormal_glial_cell1.78951934
47MP0003300_gastrointestinal_ulcer1.77992392
48MP0010630_abnormal_cardiac_muscle1.76906772
49MP0001800_abnormal_humoral_immune1.75301112
50MP0002998_abnormal_bone_remodeling1.74892581
51MP0000685_abnormal_immune_system1.73577384
52MP0002254_reproductive_system_inflammat1.71588100
53MP0002272_abnormal_nervous_system1.70865410
54MP0005369_muscle_phenotype1.69987173
55MP0003938_abnormal_ear_development1.67318019
56MP0004885_abnormal_endolymph1.67058568
57MP0004484_altered_response_of1.66401999
58MP0010678_abnormal_skin_adnexa1.64070273
59MP0009379_abnormal_foot_pigmentation1.60988070
60MP0002971_abnormal_brown_adipose1.58129393
61MP0000759_abnormal_skeletal_muscle1.57833593
62MP0005387_immune_system_phenotype1.53910813
63MP0001790_abnormal_immune_system1.53910813
64MP0005620_abnormal_muscle_contractility1.52902796
65MP0004142_abnormal_muscle_tone1.50910012
66MP0009115_abnormal_fat_cell1.48369878
67MP0002108_abnormal_muscle_morphology1.48175059
68MP0003937_abnormal_limbs/digits/tail_de1.47229813
69MP0002229_neurodegeneration1.46764351
70MP0005408_hypopigmentation1.45542828
71MP0002419_abnormal_innate_immunity1.45205479
72MP0000762_abnormal_tongue_morphology1.43083248
73MP0002009_preneoplasia1.42862784
74MP0005551_abnormal_eye_electrophysiolog1.40115236
75MP0003632_abnormal_nervous_system1.39927967
76MP0005385_cardiovascular_system_phenoty1.39136500
77MP0001544_abnormal_cardiovascular_syste1.39136500
78MP0005671_abnormal_response_to1.36989347
79MP0003011_delayed_dark_adaptation1.36396343
80MP0004510_myositis1.34760188
81MP0000647_abnormal_sebaceous_gland1.30613618
82MP0003705_abnormal_hypodermis_morpholog1.29078884
83MP0002420_abnormal_adaptive_immunity1.26824401
84MP0002127_abnormal_cardiovascular_syste1.26717217
85MP0005464_abnormal_platelet_physiology1.26138123
86MP0000372_irregular_coat_pigmentation1.26085335
87MP0001177_atelectasis1.25941788
88MP0000015_abnormal_ear_pigmentation1.25915265
89MP0000747_muscle_weakness1.25835256
90MP0001819_abnormal_immune_cell1.24570920
91MP0003279_aneurysm1.22998803
92MP0002269_muscular_atrophy1.21564064
93MP0001963_abnormal_hearing_physiology1.20235518
94MP0005375_adipose_tissue_phenotype1.20095462
95MP0008260_abnormal_autophagy1.19859259
96MP0002398_abnormal_bone_marrow1.19205876
97MP0002405_respiratory_system_inflammati1.18957287
98MP0000703_abnormal_thymus_morphology1.18473746
99MP0009250_abnormal_appendicular_skeleto1.18235754
100MP0005000_abnormal_immune_tolerance1.17839237
101MP0001533_abnormal_skeleton_physiology1.17728397
102MP0002723_abnormal_immune_serum1.16939909
103MP0005025_abnormal_response_to1.16834238
104MP0002452_abnormal_antigen_presenting1.16378753
105MP0000537_abnormal_urethra_morphology1.16307007
106MP0005330_cardiomyopathy1.16149570
107MP0000631_abnormal_neuroendocrine_gland1.13746000
108MP0002933_joint_inflammation1.13395112
109MP0000026_abnormal_inner_ear1.13364924
110MP0009278_abnormal_bone_marrow1.13003173
111MP0002972_abnormal_cardiac_muscle1.12962981
112MP0002752_abnormal_somatic_nervous1.10917795
113MP0001986_abnormal_taste_sensitivity1.10828662
114MP0004883_abnormal_blood_vessel1.10353044
115MP0005645_abnormal_hypothalamus_physiol1.10050788
116MP0005423_abnormal_somatic_nervous1.08419379
117MP0004947_skin_inflammation1.08165600
118MP0002064_seizures1.08141218
119MP0000716_abnormal_immune_system1.07717329
120MP0004215_abnormal_myocardial_fiber1.05883796
121MP0005075_abnormal_melanosome_morpholog1.04085968
122MP0008057_abnormal_DNA_replication1.03824924
123MP0008004_abnormal_stomach_pH1.03366143
124MP0000767_abnormal_smooth_muscle1.03194300
125MP0002734_abnormal_mechanical_nocicepti1.02519549
126MP0000733_abnormal_muscle_development1.02373913
127MP0005410_abnormal_fertilization1.02126430
128MP0002796_impaired_skin_barrier1.02061604
129MP0002938_white_spotting1.02041283
130MP0002332_abnormal_exercise_endurance0.99432660
131MP0005195_abnormal_posterior_eye0.98908896
132MP0003091_abnormal_cell_migration0.98109988
133MP0000689_abnormal_spleen_morphology0.97431344
134MP0002722_abnormal_immune_system0.96175367
135MP0003183_abnormal_peptide_metabolism0.95955882
136MP0005076_abnormal_cell_differentiation0.95611498
137MP0000579_abnormal_nail_morphology0.95547709
138MP0002098_abnormal_vibrissa_morphology0.95340205
139MP0001851_eye_inflammation0.94801174
140MP0002277_abnormal_respiratory_mucosa0.94220758
141MP0002882_abnormal_neuron_morphology0.94151582
142MP0002735_abnormal_chemical_nociception0.93734266
143MP0009384_cardiac_valve_regurgitation0.93709938
144MP0005334_abnormal_fat_pad0.93552351
145MP0004808_abnormal_hematopoietic_stem0.93275351
146MP0005253_abnormal_eye_physiology0.91721328
147MP0004924_abnormal_behavior0.91718962
148MP0005386_behavior/neurological_phenoty0.91718962
149MP0000462_abnormal_digestive_system0.91261343
150MP0003567_abnormal_fetal_cardiomyocyte0.91016130
151MP0010368_abnormal_lymphatic_system0.89916062
152MP0003868_abnormal_feces_composition0.89587211
153MP0003172_abnormal_lysosome_physiology0.89245623
154MP0000467_abnormal_esophagus_morphology0.88338217
155MP0001299_abnormal_eye_distance/0.87471546
156MP0010329_abnormal_lipoprotein_level0.86874009
157MP0005388_respiratory_system_phenotype0.86484482
158MP0002133_abnormal_respiratory_system0.86484482
159MP0003631_nervous_system_phenotype0.85564101
160MP0006072_abnormal_retinal_apoptosis0.84662254
161MP0002006_tumorigenesis0.84538434
162MP0009046_muscle_twitch0.84448537
163MP0001545_abnormal_hematopoietic_system0.83889344
164MP0005397_hematopoietic_system_phenotyp0.83889344
165MP0000955_abnormal_spinal_cord0.81837902
166MP0003755_abnormal_palate_morphology0.81288687
167MP0005503_abnormal_tendon_morphology0.81143376
168MP0001661_extended_life_span0.80359039
169MP0002128_abnormal_blood_circulation0.79577697
170MP0002177_abnormal_outer_ear0.78751555
171MP0008789_abnormal_olfactory_epithelium0.78219535
172MP0002102_abnormal_ear_morphology0.76710193
173MP0002751_abnormal_autonomic_nervous0.76050137
174MP0001502_abnormal_circadian_rhythm0.75605897
175MP0003385_abnormal_body_wall0.75228914
176MP0002295_abnormal_pulmonary_circulatio0.74534862
177MP0000049_abnormal_middle_ear0.74175051
178MP0008569_lethality_at_weaning0.73090097
179MP0001340_abnormal_eyelid_morphology0.70478159
180MP0009697_abnormal_copulation0.70323458
181MP0009745_abnormal_behavioral_response0.69493020
182MP0001984_abnormal_olfaction0.69251358
183MP0000613_abnormal_salivary_gland0.67969942
184MP0002067_abnormal_sensory_capabilities0.67636280
185MP0002233_abnormal_nose_morphology0.64592752
186MP0000427_abnormal_hair_cycle0.64386141
187MP0003724_increased_susceptibility_to0.63429117
188MP0002066_abnormal_motor_capabilities/c0.62770522
189MP0000465_gastrointestinal_hemorrhage0.60412022

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.39327149
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.17770554
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.17770554
4Muscle fiber inclusion bodies (HP:0100299)4.76000352
5Nemaline bodies (HP:0003798)4.71022031
6Exercise-induced myalgia (HP:0003738)4.70878054
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.64680517
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.48008792
9Sensory axonal neuropathy (HP:0003390)4.16687773
10Type 1 muscle fiber predominance (HP:0003803)4.06399688
11Abnormality of the left ventricular outflow tract (HP:0011103)3.92222291
12Subaortic stenosis (HP:0001682)3.92222291
13Difficulty running (HP:0009046)3.63728578
14Hyporeflexia of lower limbs (HP:0002600)3.55380195
15Muscle fiber splitting (HP:0003555)3.42168068
16Neurofibrillary tangles (HP:0002185)3.38775158
17White forelock (HP:0002211)3.34353204
18Adrenal hypoplasia (HP:0000835)3.31363192
19Abnormality of the corticospinal tract (HP:0002492)3.30626458
20Patchy hypopigmentation of hair (HP:0011365)3.28990071
21Muscle hypertrophy of the lower extremities (HP:0008968)3.25146255
22Eczematoid dermatitis (HP:0000976)3.25099102
23Calf muscle hypertrophy (HP:0008981)3.19964090
24Aortic aneurysm (HP:0004942)3.18072261
25Distal arthrogryposis (HP:0005684)3.16515759
26Abnormality of skeletal muscle fiber size (HP:0012084)3.15975464
27Congenital ichthyosiform erythroderma (HP:0007431)3.10837504
28Increased variability in muscle fiber diameter (HP:0003557)3.05686251
29Exercise-induced muscle cramps (HP:0003710)3.05518605
30Cupped ear (HP:0000378)3.05439862
31Absent septum pellucidum (HP:0001331)3.04699482
32Stomach cancer (HP:0012126)2.93578131
33Spontaneous hematomas (HP:0007420)2.93249348
34Peripheral hypomyelination (HP:0007182)2.93194960
35Sudden death (HP:0001699)2.88779379
36Asymmetric septal hypertrophy (HP:0001670)2.86059123
37Akinesia (HP:0002304)2.85176029
38Abnormality of the septum pellucidum (HP:0007375)2.80190188
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.79385203
40Submucous cleft hard palate (HP:0000176)2.76749683
41Septo-optic dysplasia (HP:0100842)2.72507246
42Split foot (HP:0001839)2.70571291
43Thickened helices (HP:0000391)2.70149169
44Autoamputation (HP:0001218)2.67579707
45Abnormality of incisor morphology (HP:0011063)2.67514470
46Abnormality of the renal collecting system (HP:0004742)2.60781626
47Neck muscle weakness (HP:0000467)2.59592253
48T lymphocytopenia (HP:0005403)2.59561896
49Duplicated collecting system (HP:0000081)2.58290553
50Partial duplication of thumb phalanx (HP:0009944)2.58233335
51EMG: myopathic abnormalities (HP:0003458)2.55711363
52Increased IgE level (HP:0003212)2.52313922
53Abnormality of the nasal septum (HP:0000419)2.49057144
54Alacrima (HP:0000522)2.47621236
55Gastrointestinal infarctions (HP:0005244)2.43025123
56Abnormality of the calf musculature (HP:0001430)2.42782898
57Abnormality of the phalanges of the 2nd finger (HP:0009541)2.37416314
58Nasolacrimal duct obstruction (HP:0000579)2.37373996
59Onion bulb formation (HP:0003383)2.36165273
60Abnormal auditory evoked potentials (HP:0006958)2.35113033
61Hypothermia (HP:0002045)2.33904977
62Spastic gait (HP:0002064)2.32415618
63Abnormality of the fingertips (HP:0001211)2.30841523
64Abnormality of T cell number (HP:0011839)2.29417588
65Ulnar deviation of the wrist (HP:0003049)2.28486528
66Peritonitis (HP:0002586)2.26747333
67Retinal dysplasia (HP:0007973)2.26574955
68Prolonged neonatal jaundice (HP:0006579)2.26413887
69Hypoplastic pelvis (HP:0008839)2.24438077
70Cerebral hypomyelination (HP:0006808)2.23651598
71Deep venous thrombosis (HP:0002625)2.23580738
72Abnormal hair whorl (HP:0010721)2.23392478
73Round ear (HP:0100830)2.22532937
74Premature skin wrinkling (HP:0100678)2.22512896
753-Methylglutaconic aciduria (HP:0003535)2.22441119
76Colitis (HP:0002583)2.21859157
77Conical tooth (HP:0000698)2.20382824
78Partial duplication of the phalanx of hand (HP:0009999)2.15216680
79Aplasia involving bones of the upper limbs (HP:0009823)2.14548570
80Aplasia of the phalanges of the hand (HP:0009802)2.14548570
81Aplasia involving bones of the extremities (HP:0009825)2.14548570
82Recurrent gram-negative bacterial infections (HP:0005420)2.13436284
83Frequent falls (HP:0002359)2.12788762
84Renal Fanconi syndrome (HP:0001994)2.11499893
85Vaginal atresia (HP:0000148)2.09565095
86Erythroderma (HP:0001019)2.09252602
87Areflexia of lower limbs (HP:0002522)2.09093952
88Duplication of thumb phalanx (HP:0009942)2.08998859
89Leukodystrophy (HP:0002415)2.08342286
90Genital tract atresia (HP:0001827)2.08259774
91Hepatoblastoma (HP:0002884)2.07531742
92Myopathic facies (HP:0002058)2.07105411
93Abnormality of the nasolacrimal system (HP:0000614)2.06533401
94Complement deficiency (HP:0004431)2.06316493
95Hypomagnesemia (HP:0002917)2.05292141
96Myelomeningocele (HP:0002475)2.05195805
97Abnormality of the lumbar spine (HP:0100712)2.03270430
98Abnormality of glycolysis (HP:0004366)2.02896958
99Increased serum pyruvate (HP:0003542)2.02896958
100Abnormality of the lacrimal duct (HP:0011481)2.02874143
101Myositis (HP:0100614)2.02705172
102Abnormal delayed hypersensitivity skin test (HP:0002963)2.02640962
103Prolonged bleeding time (HP:0003010)2.01990948
104Joint hemorrhage (HP:0005261)2.00962483
105Gingival bleeding (HP:0000225)1.99630543
106Chest pain (HP:0100749)1.99599056
107Anomalous pulmonary venous return (HP:0010772)1.98611230
108Aortic dissection (HP:0002647)1.98479608
109Abnormality of the columella (HP:0009929)1.98384063
110Poor speech (HP:0002465)1.97932002
111Neonatal hypoglycemia (HP:0001998)1.97495661
112Morphological abnormality of the inner ear (HP:0011390)1.96811035
113Dysmetric saccades (HP:0000641)1.95763363
114Anteriorly placed anus (HP:0001545)1.95448768
115Panhypogammaglobulinemia (HP:0003139)1.93504080
116Obstructive sleep apnea (HP:0002870)1.93075436
117Congenital sensorineural hearing impairment (HP:0008527)1.92557476
118Thoracic kyphosis (HP:0002942)1.92193269
119Recurrent fungal infections (HP:0002841)1.92088678
120Bell-shaped thorax (HP:0001591)1.91442177
121Spastic paraparesis (HP:0002313)1.91239221
122Decreased lacrimation (HP:0000633)1.91170987
123Stridor (HP:0010307)1.90929455
124Methylmalonic acidemia (HP:0002912)1.90397751
125Hepatosplenomegaly (HP:0001433)1.90084801
126Optic nerve hypoplasia (HP:0000609)1.88610962
127Hyperkalemia (HP:0002153)1.88442226
128Mitral valve prolapse (HP:0001634)1.86275002
129Inflammation of the large intestine (HP:0002037)1.85265741
130Bundle branch block (HP:0011710)1.85232500
131Facial diplegia (HP:0001349)1.84453947
132Lip pit (HP:0100267)1.83964001
133Abnormality of the axillary hair (HP:0100134)1.82884690
134Abnormality of secondary sexual hair (HP:0009888)1.82884690
135Recurrent cutaneous fungal infections (HP:0011370)1.82304721
136Chronic mucocutaneous candidiasis (HP:0002728)1.82304721
137EMG: neuropathic changes (HP:0003445)1.82157436
138Muscle stiffness (HP:0003552)1.82154281
139Meningitis (HP:0001287)1.81251084
140Malignant hyperthermia (HP:0002047)1.81238899
141Pulmonary embolism (HP:0002204)1.80947026
142Orchitis (HP:0100796)1.80309221
143Rhabdomyolysis (HP:0003201)1.80151826
144Ventricular tachycardia (HP:0004756)1.80001098
145Midline defect of the nose (HP:0004122)1.78529788
146Dysmetria (HP:0001310)1.78101626
147Slow saccadic eye movements (HP:0000514)1.77654910
148Recurrent bacterial skin infections (HP:0005406)1.77577225
149Intention tremor (HP:0002080)1.77356167
150Hypoplastic left heart (HP:0004383)1.77127003
151Spondylolisthesis (HP:0003302)1.76614270
152Vascular calcification (HP:0004934)1.76562915
153Scanning speech (HP:0002168)1.76033031
154Gastrointestinal inflammation (HP:0004386)1.75952307
155Retrobulbar optic neuritis (HP:0100654)1.75805020
156Optic neuritis (HP:0100653)1.75805020
157Diminished movement (HP:0002374)1.75704454
158Abnormality of the peritoneum (HP:0002585)1.75554231
159Barrel-shaped chest (HP:0001552)1.74194816
160Recurrent corneal erosions (HP:0000495)1.74102219
161Pulmonary artery stenosis (HP:0004415)1.73847384
162Ventricular fibrillation (HP:0001663)1.73594349
163Epistaxis (HP:0000421)1.73286386
164Arterial thrombosis (HP:0004420)1.73262156
165Abnormality of the pulmonary veins (HP:0011718)1.73092514
166Overfolded helix (HP:0000396)1.72726913
167Aneurysm (HP:0002617)1.72684945
168Rimmed vacuoles (HP:0003805)1.72683024
169Hypoplasia of the iris (HP:0007676)1.72527111
170Gastrointestinal atresia (HP:0002589)1.71192223
171Scapular winging (HP:0003691)1.70670789
172Abnormality of the parietal bone (HP:0002696)1.70626655
173Cerebral aneurysm (HP:0004944)1.70079622
174Increased connective tissue (HP:0009025)1.69372280
175Generalized muscle weakness (HP:0003324)1.69370292
176Right ventricular cardiomyopathy (HP:0011663)1.68537265
177Widely spaced teeth (HP:0000687)1.67906447
178Atrioventricular block (HP:0001678)1.67107061
179Paraparesis (HP:0002385)1.66909418
180Arterial tortuosity (HP:0005116)1.66809970
181Steppage gait (HP:0003376)1.66611835
182Medial flaring of the eyebrow (HP:0010747)1.66297255
183Agammaglobulinemia (HP:0004432)1.65676299
184Septate vagina (HP:0001153)1.65510301
185Pheochromocytoma (HP:0002666)1.64818600
186Recurrent skin infections (HP:0001581)1.63887954
187Systemic lupus erythematosus (HP:0002725)1.63861389
188Stenosis of the external auditory canal (HP:0000402)1.63493576
189Protrusio acetabuli (HP:0003179)1.63327968
190Vascular tortuosity (HP:0004948)1.63251962
191Metabolic alkalosis (HP:0200114)1.62922967
192Overgrowth (HP:0001548)1.60652096
193Gingivitis (HP:0000230)1.60599926
194Anhidrosis (HP:0000970)1.60580691
195Recurrent abscess formation (HP:0002722)1.60434750
196Humeroradial synostosis (HP:0003041)1.60404245
197Papilledema (HP:0001085)1.58995976
198Keratoconjunctivitis sicca (HP:0001097)1.57875032
199Esophageal varix (HP:0002040)1.57705753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.44877106
2STK394.81177577
3OXSR13.70882881
4EPHB12.73263919
5TNIK2.37683122
6CASK2.32182893
7TTN2.27545421
8MAP3K102.22582526
9BCR2.20953386
10NEK62.12105292
11PKN12.08436487
12NUAK12.08188622
13MAP4K12.06721450
14FGFR22.02965819
15PIK3CG2.01982334
16PBK1.98626450
17CLK11.94942435
18EEF2K1.92956570
19FGFR31.92450434
20MST41.91662081
21CDK191.88082606
22CDK121.79436628
23MAP3K71.78263130
24FGFR41.70965469
25MAPK121.70568488
26MAP3K131.69577044
27BMPR1B1.68159073
28SGK31.66184645
29MAPKAPK51.52295576
30MAP2K31.51521428
31WNK11.51287691
32FES1.47395866
33MET1.47068249
34RIPK41.46695381
35DMPK1.41765536
36WNK41.39720631
37EPHA31.39176255
38TYK21.34203961
39ZAP701.32103955
40SGK2231.31674897
41SGK4941.31674897
42LATS11.30364940
43TRPM71.27832957
44MUSK1.27243726
45BLK1.26768541
46ZAK1.24781278
47TGFBR21.21485048
48CDC42BPA1.21130173
49YES11.20441517
50LIMK11.19464564
51CSK1.18304445
52KIT1.17848977
53SYK1.17737370
54ROCK21.17171809
55ERN11.16214237
56CSNK1G31.15942895
57RIPK11.15494130
58CSNK1A1L1.14473311
59JAK31.12682863
60OBSCN1.11852004
61BTK1.10471959
62JAK11.09506336
63DYRK21.07875059
64MKNK11.05664835
65CSNK1G11.04293354
66TESK21.03816656
67MARK31.02188920
68PAK30.98074816
69ERBB40.96644714
70PRKAA20.96116439
71MAPK150.94862888
72CAMK1D0.94711927
73BRD40.93589187
74CAMK2D0.93092363
75CAMK2B0.92424546
76HCK0.91567080
77TRIB30.91169762
78CAMK1G0.90181206
79PIK3CA0.88464165
80MELK0.88066272
81MAPK70.87134989
82PNCK0.86640583
83MAP3K140.86570080
84NEK90.86361518
85TEC0.85943836
86UHMK10.84530326
87GRK60.83844199
88MKNK20.81906675
89CAMK40.81210921
90CDK60.80253148
91MARK20.79311559
92JAK20.78521612
93TYRO30.78412702
94PDK10.77338477
95CSNK1G20.75958153
96MARK10.75825000
97GRK70.75797803
98BMPR20.75489292
99MAP3K10.74025320
100CSF1R0.73756355
101PDGFRB0.72892615
102SGK10.72853775
103STK110.72057325
104MAPK130.71949501
105PRKCQ0.70514855
106MAP2K20.69948246
107PDGFRA0.69453112
108SGK20.69243053
109TNK20.69078075
110IRAK10.68988752
111STK160.68568824
112ADRBK20.67624825
113IKBKE0.66242984
114MAP3K60.64906618
115CDK30.64324625
116IRAK40.63775305
117DYRK1B0.63752274
118EIF2AK20.63631349
119RET0.63507872
120IRAK20.62649104
121CDK40.62240130
122TXK0.61926230
123RPS6KA50.61906322
124AKT30.61862132
125CAMK10.60377509
126PRKCE0.58915702
127STK240.58231479
128IKBKB0.57807388
129LYN0.56121330
130PRKCH0.55491677
131SIK20.55297300
132PDPK10.54946078
133TIE10.54703077
134MAPK40.54406572
135MTOR0.54070724
136FGR0.53448564
137RPS6KB10.53337933
138PIM10.53105013
139CAMK2G0.51851479
140PRKG10.51242438
141RPS6KC10.51183565
142RPS6KL10.51183565
143STK30.50806296
144CAMK2A0.48745167
145STK38L0.47734215
146GRK10.47363920
147TAOK30.45648931
148VRK10.45309696
149ITK0.44475075
150MATK0.43521126
151NLK0.40502695
152HIPK20.39151062
153PRKD10.38132347
154CSNK1D0.36886640
155LCK0.35255017
156EPHA40.34476682
157GSK3A0.33674028
158INSRR0.32047362
159ICK0.31446987
160ROCK10.31191848
161DYRK1A0.31007804
162IRAK30.30804594
163CDK50.28869084
164CSNK1A10.27221073
165CDK180.26157238
166MYLK0.25774464
167CDK150.24922975
168PRKACA0.23961842
169CDK140.23675619
170PRKACB0.23538195
171PINK10.23297359
172CDK11A0.21649330
173NTRK20.21511166

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.32664595
2Steroid biosynthesis_Homo sapiens_hsa001004.15594516
3Fatty acid elongation_Homo sapiens_hsa000624.10372657
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.45601114
5Ether lipid metabolism_Homo sapiens_hsa005653.08439288
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.65197340
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55948232
8Sphingolipid metabolism_Homo sapiens_hsa006002.39946743
9Protein export_Homo sapiens_hsa030602.28391076
10Sulfur metabolism_Homo sapiens_hsa009202.09998432
11Staphylococcus aureus infection_Homo sapiens_hsa051502.09519886
12Linoleic acid metabolism_Homo sapiens_hsa005911.89881359
13Axon guidance_Homo sapiens_hsa043601.89494378
14B cell receptor signaling pathway_Homo sapiens_hsa046621.87054072
15Autoimmune thyroid disease_Homo sapiens_hsa053201.84352186
16Arachidonic acid metabolism_Homo sapiens_hsa005901.72426031
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70022795
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62716198
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.60527723
20Oxidative phosphorylation_Homo sapiens_hsa001901.58746536
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54942965
22Platelet activation_Homo sapiens_hsa046111.53756002
23Osteoclast differentiation_Homo sapiens_hsa043801.43224218
24Leishmaniasis_Homo sapiens_hsa051401.41900587
25Acute myeloid leukemia_Homo sapiens_hsa052211.41262937
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41144994
27Vitamin B6 metabolism_Homo sapiens_hsa007501.39405416
28Histidine metabolism_Homo sapiens_hsa003401.39038046
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38629899
30Serotonergic synapse_Homo sapiens_hsa047261.35022157
31Insulin resistance_Homo sapiens_hsa049311.34496679
32Dilated cardiomyopathy_Homo sapiens_hsa054141.27643496
33Long-term potentiation_Homo sapiens_hsa047201.26625527
34Renin secretion_Homo sapiens_hsa049241.25083706
35Complement and coagulation cascades_Homo sapiens_hsa046101.22727157
36Dorso-ventral axis formation_Homo sapiens_hsa043201.18546812
37Rheumatoid arthritis_Homo sapiens_hsa053231.18507674
38Viral myocarditis_Homo sapiens_hsa054161.17741686
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17352675
40FoxO signaling pathway_Homo sapiens_hsa040681.16065498
41Non-small cell lung cancer_Homo sapiens_hsa052231.15935445
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15147721
43Oxytocin signaling pathway_Homo sapiens_hsa049211.13100361
44Endometrial cancer_Homo sapiens_hsa052131.12955018
45Non-homologous end-joining_Homo sapiens_hsa034501.12873782
46Circadian rhythm_Homo sapiens_hsa047101.11350736
47Insulin signaling pathway_Homo sapiens_hsa049101.09369449
48GnRH signaling pathway_Homo sapiens_hsa049121.08105772
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.06843617
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.05365302
51Glucagon signaling pathway_Homo sapiens_hsa049221.04991084
52Malaria_Homo sapiens_hsa051441.04798284
53Chronic myeloid leukemia_Homo sapiens_hsa052201.04573303
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04153015
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03533308
56Renal cell carcinoma_Homo sapiens_hsa052111.03215824
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02540852
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.02145627
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.01547728
60Parkinsons disease_Homo sapiens_hsa050121.01096245
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.99819608
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99643957
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98468815
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97752454
65Tuberculosis_Homo sapiens_hsa051520.96316043
66Colorectal cancer_Homo sapiens_hsa052100.95908562
67Graft-versus-host disease_Homo sapiens_hsa053320.95166749
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95049840
69Alzheimers disease_Homo sapiens_hsa050100.95043272
70Allograft rejection_Homo sapiens_hsa053300.94928440
71Renin-angiotensin system_Homo sapiens_hsa046140.94900306
72Basal transcription factors_Homo sapiens_hsa030220.93499067
73Retinol metabolism_Homo sapiens_hsa008300.93102508
74PPAR signaling pathway_Homo sapiens_hsa033200.92315969
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91270267
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91245818
77Tight junction_Homo sapiens_hsa045300.90773191
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90716981
79Adherens junction_Homo sapiens_hsa045200.88895136
80Prolactin signaling pathway_Homo sapiens_hsa049170.87899020
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87400619
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86821099
83Glutathione metabolism_Homo sapiens_hsa004800.85304644
84Phototransduction_Homo sapiens_hsa047440.84863755
85Ras signaling pathway_Homo sapiens_hsa040140.83945092
86Ovarian steroidogenesis_Homo sapiens_hsa049130.82750589
87Focal adhesion_Homo sapiens_hsa045100.82313321
88RNA polymerase_Homo sapiens_hsa030200.82220458
89Pancreatic cancer_Homo sapiens_hsa052120.82069338
90Toxoplasmosis_Homo sapiens_hsa051450.81990685
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81083229
92AMPK signaling pathway_Homo sapiens_hsa041520.80446014
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79784013
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79380996
95Lysine degradation_Homo sapiens_hsa003100.79305523
96Measles_Homo sapiens_hsa051620.77771049
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77407565
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76936599
99mTOR signaling pathway_Homo sapiens_hsa041500.76324141
100Asthma_Homo sapiens_hsa053100.75877233
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75440084
102Basal cell carcinoma_Homo sapiens_hsa052170.75331926
103Amoebiasis_Homo sapiens_hsa051460.74657705
104Estrogen signaling pathway_Homo sapiens_hsa049150.72998586
105Hedgehog signaling pathway_Homo sapiens_hsa043400.72445375
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72161616
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.72041605
108VEGF signaling pathway_Homo sapiens_hsa043700.70144049
109Calcium signaling pathway_Homo sapiens_hsa040200.70091648
110ErbB signaling pathway_Homo sapiens_hsa040120.69390157
111T cell receptor signaling pathway_Homo sapiens_hsa046600.69067268
112Influenza A_Homo sapiens_hsa051640.68013721
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67525949
114Wnt signaling pathway_Homo sapiens_hsa043100.67491483
115Hepatitis B_Homo sapiens_hsa051610.66179830
116Glioma_Homo sapiens_hsa052140.66057607
117Fatty acid degradation_Homo sapiens_hsa000710.65710651
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65622129
119Type I diabetes mellitus_Homo sapiens_hsa049400.64749968
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63865936
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63409894
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63223109
123Gastric acid secretion_Homo sapiens_hsa049710.61202480
124Inositol phosphate metabolism_Homo sapiens_hsa005620.60502923
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.60466714
126cAMP signaling pathway_Homo sapiens_hsa040240.60377169
127Chemical carcinogenesis_Homo sapiens_hsa052040.59836129
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58373672
129Arginine and proline metabolism_Homo sapiens_hsa003300.58163078
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.57987201
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56539523
132Choline metabolism in cancer_Homo sapiens_hsa052310.56312785
133Rap1 signaling pathway_Homo sapiens_hsa040150.55592380
134Glutamatergic synapse_Homo sapiens_hsa047240.55508022
135Long-term depression_Homo sapiens_hsa047300.52757424
136Type II diabetes mellitus_Homo sapiens_hsa049300.52664338
137MicroRNAs in cancer_Homo sapiens_hsa052060.52521859
138Vitamin digestion and absorption_Homo sapiens_hsa049770.52285830
139Peroxisome_Homo sapiens_hsa041460.52128742
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51964055
141Huntingtons disease_Homo sapiens_hsa050160.50584262
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50286410
143TGF-beta signaling pathway_Homo sapiens_hsa043500.46849500
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.46540587
145Taste transduction_Homo sapiens_hsa047420.46003459
146Endocytosis_Homo sapiens_hsa041440.45491130
147Regulation of autophagy_Homo sapiens_hsa041400.45113084
148Butanoate metabolism_Homo sapiens_hsa006500.43831614
149Prostate cancer_Homo sapiens_hsa052150.43212903
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.43035374
151Phagosome_Homo sapiens_hsa041450.42099393
152Hematopoietic cell lineage_Homo sapiens_hsa046400.42085945
153Hippo signaling pathway_Homo sapiens_hsa043900.41861319
154MAPK signaling pathway_Homo sapiens_hsa040100.41856222
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.41840626
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41599492
157Cardiac muscle contraction_Homo sapiens_hsa042600.40988503
158Morphine addiction_Homo sapiens_hsa050320.40105331
159PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39432405
160Metabolic pathways_Homo sapiens_hsa011000.39337898
161ABC transporters_Homo sapiens_hsa020100.38881950
162Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38812635
163ECM-receptor interaction_Homo sapiens_hsa045120.38132327
164Notch signaling pathway_Homo sapiens_hsa043300.38030619
165Primary immunodeficiency_Homo sapiens_hsa053400.37907330
166Hepatitis C_Homo sapiens_hsa051600.35199381
167Chemokine signaling pathway_Homo sapiens_hsa040620.35166751
168Mineral absorption_Homo sapiens_hsa049780.34408858
169Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33373525
170GABAergic synapse_Homo sapiens_hsa047270.33257137
171RNA degradation_Homo sapiens_hsa030180.32064900
172Fanconi anemia pathway_Homo sapiens_hsa034600.30506733
173Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29264693

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