FOXO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)4.58519363
2definitive hemopoiesis (GO:0060216)4.13097988
3glucocorticoid receptor signaling pathway (GO:0042921)3.80628845
4embryonic process involved in female pregnancy (GO:0060136)3.77898261
5protoporphyrinogen IX biosynthetic process (GO:0006782)3.72567570
6histone H3-K9 demethylation (GO:0033169)3.71977284
7histone lysine demethylation (GO:0070076)3.64558655
8histone H3-K36 demethylation (GO:0070544)3.62115162
9cytoplasmic mRNA processing body assembly (GO:0033962)3.59128700
10histone demethylation (GO:0016577)3.54768516
11receptor recycling (GO:0001881)3.52860601
12megakaryocyte development (GO:0035855)3.48420883
13fibroblast migration (GO:0010761)3.48005599
14negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.43048915
15erythrocyte development (GO:0048821)3.40514407
16protein demethylation (GO:0006482)3.39552834
17protein dealkylation (GO:0008214)3.39552834
18negative regulation of histone methylation (GO:0031061)3.33704662
19negative regulation of glial cell proliferation (GO:0060253)3.33117182
20microglial cell activation (GO:0001774)3.27026279
21hepatocyte apoptotic process (GO:0097284)3.26007340
22corticosteroid receptor signaling pathway (GO:0031958)3.24274364
23negative regulation of erythrocyte differentiation (GO:0045647)3.22594007
24positive regulation of receptor recycling (GO:0001921)3.19813455
25positive regulation of histone deacetylation (GO:0031065)3.19552496
26insulin-like growth factor receptor signaling pathway (GO:0048009)3.19060326
27regulation of protein polyubiquitination (GO:1902914)3.18827400
28nuclear pore complex assembly (GO:0051292)3.17883734
29hemoglobin metabolic process (GO:0020027)3.16466087
30negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14455815
31embryonic camera-type eye morphogenesis (GO:0048596)3.11320469
32embryonic hemopoiesis (GO:0035162)3.08899068
33negative regulation of histone modification (GO:0031057)3.07652019
34phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.06424926
35pre-miRNA processing (GO:0031054)3.05683305
36porphyrin-containing compound biosynthetic process (GO:0006779)3.05222486
37dosage compensation (GO:0007549)3.02471619
38detection of molecule of bacterial origin (GO:0032490)2.98566671
39positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98112316
40positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98112316
41positive regulation of mitotic sister chromatid separation (GO:1901970)2.98112316
42monoubiquitinated protein deubiquitination (GO:0035520)2.96886012
43histone H3-K4 trimethylation (GO:0080182)2.93637189
44cellular response to epinephrine stimulus (GO:0071872)2.91436790
45iron ion import (GO:0097286)2.91360886
46nuclear pore organization (GO:0006999)2.90367538
47erythrocyte maturation (GO:0043249)2.89169756
48growth hormone receptor signaling pathway (GO:0060396)2.87015578
49macroautophagy (GO:0016236)2.85484594
50regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.83015169
51negative regulation of neurotransmitter transport (GO:0051589)2.82871750
52histone H3-K4 methylation (GO:0051568)2.81383959
53negative regulation of DNA repair (GO:0045738)2.78701694
54oxygen transport (GO:0015671)2.78053556
55protein K11-linked deubiquitination (GO:0035871)2.74301127
56positive regulation of insulin receptor signaling pathway (GO:0046628)2.72798607
57myeloid cell development (GO:0061515)2.71504147
58embryonic eye morphogenesis (GO:0048048)2.71001577
59negative regulation of chromatin modification (GO:1903309)2.70794787
60response to methylmercury (GO:0051597)2.70663143
61positive regulation of p38MAPK cascade (GO:1900745)2.69864296
62regulation of translational termination (GO:0006449)2.69285944
63positive regulation of protein deacetylation (GO:0090312)2.67887240
64positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.66255534
65regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.66255534
66macrophage activation (GO:0042116)2.65560221
67nerve growth factor signaling pathway (GO:0038180)2.64755940
68embryonic placenta development (GO:0001892)2.63299333
69mitotic sister chromatid cohesion (GO:0007064)2.62829411
70regulation of beta-amyloid formation (GO:1902003)2.61346212
71import into cell (GO:0098657)2.61288776
72tetrapyrrole biosynthetic process (GO:0033014)2.61087711
73neutrophil mediated immunity (GO:0002446)2.57993199
74gas transport (GO:0015669)2.57792585
75nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.57553079
76mitotic chromosome condensation (GO:0007076)2.56378645
77cardiac myofibril assembly (GO:0055003)2.55952727
78regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55372291
79regulation of response to osmotic stress (GO:0047484)2.54133183
80positive regulation of mRNA catabolic process (GO:0061014)2.53709070
81regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.52817717
82embryonic retina morphogenesis in camera-type eye (GO:0060059)2.51994237
83negative regulation of fatty acid transport (GO:2000192)2.51722779
84pore complex assembly (GO:0046931)2.51024594
85negative regulation of histone acetylation (GO:0035067)2.49428055
86regulation of p38MAPK cascade (GO:1900744)2.49075510
87paraxial mesoderm development (GO:0048339)2.48999124
88regulation of necroptotic process (GO:0060544)2.48885582
89regulation of glial cell proliferation (GO:0060251)2.47392604
90regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47052593
91cerebellar Purkinje cell differentiation (GO:0021702)2.46882190
92erythrocyte differentiation (GO:0030218)2.46765472
93regulation of histone H3-K9 methylation (GO:0051570)2.45678379
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.43223323
95sister chromatid segregation (GO:0000819)2.41024235
96cellular extravasation (GO:0045123)2.40465149
97positive regulation of gamma-delta T cell activation (GO:0046645)2.39439549
98cerebellar granule cell differentiation (GO:0021707)2.38645194
99histone H2A monoubiquitination (GO:0035518)2.38503576
100DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.37490006
101cellular response to growth hormone stimulus (GO:0071378)2.37449428
102myeloid leukocyte mediated immunity (GO:0002444)2.36459347
103macrophage activation involved in immune response (GO:0002281)2.36381467
104positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.35954630
105negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.35808347
106mRNA stabilization (GO:0048255)2.35271938
107RNA stabilization (GO:0043489)2.35271938
108regulation of ARF protein signal transduction (GO:0032012)2.35257266
109response to epinephrine (GO:0071871)2.34317615
110negative regulation of hormone biosynthetic process (GO:0032353)2.34211076
111negative regulation of hormone metabolic process (GO:0032351)2.34211076
112positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.33525258
113regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.33525258
114regulation of platelet aggregation (GO:0090330)2.31899229
115negative regulation of peptidyl-lysine acetylation (GO:2000757)2.30112100
116gene silencing by RNA (GO:0031047)2.30042379
117hemopoiesis (GO:0030097)2.29081095
118cellular response to ethanol (GO:0071361)2.28586844
119histone lysine methylation (GO:0034968)2.28345264
120sister chromatid cohesion (GO:0007062)2.28183185
121mitotic sister chromatid segregation (GO:0000070)2.27426471
122negative regulation of inclusion body assembly (GO:0090084)2.27215975
123protein K48-linked deubiquitination (GO:0071108)2.27125755
124positive regulation of fatty acid beta-oxidation (GO:0032000)2.27088097
125cellular response to catecholamine stimulus (GO:0071870)2.26239200
126cellular response to monoamine stimulus (GO:0071868)2.26239200
127demethylation (GO:0070988)2.25860284
128porphyrin-containing compound metabolic process (GO:0006778)2.25149417
129regulation of clathrin-mediated endocytosis (GO:2000369)2.24159040
130mitotic G1 DNA damage checkpoint (GO:0031571)2.24112449
131* regulation of erythrocyte differentiation (GO:0045646)2.23689986
132actin filament capping (GO:0051693)2.23432600
133platelet formation (GO:0030220)2.23412195
134regulation of mRNA catabolic process (GO:0061013)2.22230515
135negative regulation of granulocyte differentiation (GO:0030853)2.21754480
136regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.21754203
137regulation of sister chromatid cohesion (GO:0007063)2.21319328
138negative regulation of cAMP-mediated signaling (GO:0043951)2.20856673
139positive regulation of cellular response to insulin stimulus (GO:1900078)2.20815197
140striated muscle atrophy (GO:0014891)2.20151659
141negative regulation of neurotransmitter secretion (GO:0046929)2.19806030
142chromatin assembly (GO:0031497)2.19453120
143trophectodermal cell differentiation (GO:0001829)2.18885023
144positive regulation of gene expression, epigenetic (GO:0045815)2.18786785
145negative regulation of cell killing (GO:0031342)2.18607637
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.18607637
147interkinetic nuclear migration (GO:0022027)2.17494749
148positive regulation of cellular amide metabolic process (GO:0034250)2.17049687
149retrograde transport, vesicle recycling within Golgi (GO:0000301)2.14926899
150skeletal muscle adaptation (GO:0043501)2.13599784
151interleukin-6-mediated signaling pathway (GO:0070102)2.12496699
152cytoskeletal anchoring at plasma membrane (GO:0007016)2.12436588
153positive regulation of neurotransmitter secretion (GO:0001956)2.11594573
154cortical actin cytoskeleton organization (GO:0030866)2.10562161
155negative regulation of smooth muscle cell differentiation (GO:0051151)2.09306256
156positive T cell selection (GO:0043368)2.08189215
157hypotonic response (GO:0006971)2.04789680
158peptidyl-threonine phosphorylation (GO:0018107)2.04075415
159positive regulation by symbiont of host defense response (GO:0052509)1.99184707
160modulation by symbiont of host defense response (GO:0052031)1.99184707
161modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.99184707
162modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.99184707
163positive regulation by organism of defense response of other organism involved in symbiotic interact1.99184707
164modulation by symbiont of host immune response (GO:0052553)1.99184707
165establishment of nucleus localization (GO:0040023)1.99107968
166cell differentiation in hindbrain (GO:0021533)1.98859678
167regulation of inositol phosphate biosynthetic process (GO:0010919)1.97100818
168regulation of response to reactive oxygen species (GO:1901031)1.95871357
169regulation of gamma-delta T cell activation (GO:0046643)1.95866084
170detection of external biotic stimulus (GO:0098581)1.95711133
171response to monoamine (GO:0071867)1.95710753
172response to catecholamine (GO:0071869)1.95710753
173negative regulation of exocytosis (GO:0045920)1.95235572
174establishment of protein localization to Golgi (GO:0072600)1.94664380
175positive regulation of fibroblast migration (GO:0010763)1.94263779
176regulation of cAMP-dependent protein kinase activity (GO:2000479)1.94134709
177early endosome to late endosome transport (GO:0045022)1.93576853
178negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.93046361
179N-terminal protein amino acid acetylation (GO:0006474)1.92378739
180negative regulation of anoikis (GO:2000811)1.92377912
181protein targeting to Golgi (GO:0000042)1.92205920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.08082929
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.96742960
3GATA1_22025678_ChIP-Seq_K562_Human3.46540469
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.19725692
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14273807
6* SCL_19346495_ChIP-Seq_HPC-7_Human3.02800135
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70204547
8* MYC_22102868_ChIP-Seq_BL_Human2.63750871
9* TCF7_22412390_ChIP-Seq_EML_Mouse2.57314120
10* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.50802041
11* GATA1_19941826_ChIP-Seq_K562_Human2.45976430
12GATA1_19941827_ChIP-Seq_MEL_Mouse2.38405269
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35438228
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.09568778
15ZNF263_19887448_ChIP-Seq_K562_Human2.02419309
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96248196
17* KDM2B_26808549_Chip-Seq_DND41_Human1.91355632
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88244393
19* GATA2_19941826_ChIP-Seq_K562_Human1.83704123
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82711695
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80704203
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77352609
23* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.77195668
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70443740
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69236600
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69087026
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.67560627
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61747367
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.60876950
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.58985288
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55569426
32KDM2B_26808549_Chip-Seq_K562_Human1.55018077
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54786167
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.53940003
35* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.53526791
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50840069
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50064506
38* NCOR1_26117541_ChIP-Seq_K562_Human1.48570064
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48349064
40* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.48053418
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47082222
42* VDR_24787735_ChIP-Seq_THP-1_Human1.44904671
43* VDR_21846776_ChIP-Seq_THP-1_Human1.44557090
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43913930
45* KDM2B_26808549_Chip-Seq_JURKAT_Human1.43636658
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43229793
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43224881
48* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41617934
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38876249
50EZH2_22144423_ChIP-Seq_EOC_Human1.38685401
51CLOCK_20551151_ChIP-Seq_293T_Human1.38683254
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38028459
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.37515570
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.37188454
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.37119863
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34218110
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34150971
58AR_21572438_ChIP-Seq_LNCaP_Human1.33545786
59RUNX_20019798_ChIP-Seq_JUKART_Human1.32820386
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31221664
61MAF_26560356_Chip-Seq_TH1_Human1.30796664
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.29505997
63* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28193686
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.27008166
65* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26981024
66* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25705556
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24523530
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.24425392
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24260091
70* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23853136
71GATA6_25053715_ChIP-Seq_YYC3_Human1.22044836
72AR_21909140_ChIP-Seq_LNCAP_Human1.21822185
73* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21758990
74KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21707230
75* UTX_26944678_Chip-Seq_JUKART_Human1.21194477
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.20349744
77* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20197175
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.19702641
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.19339123
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18776847
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17644570
82* LXR_22158963_ChIP-Seq_LIVER_Mouse1.17614260
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17173215
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17043597
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17015914
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.16760366
87* RXR_22158963_ChIP-Seq_LIVER_Mouse1.16694256
88PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16314786
89AHR_22903824_ChIP-Seq_MCF-7_Human1.15145130
90* ATF3_27146783_Chip-Seq_COLON_Human1.15040180
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14729211
92* RNF2_27304074_Chip-Seq_ESCs_Mouse1.14543174
93CIITA_25753668_ChIP-Seq_RAJI_Human1.14316923
94FOXA2_19822575_ChIP-Seq_HepG2_Human1.13455584
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13294055
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13294055
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.13009901
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12610320
99GBX2_23144817_ChIP-Seq_PC3_Human1.11621907
100* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11326029
101* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11145921
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10859070
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10465300
104PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10349939
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.09652862
106MYB_26560356_Chip-Seq_TH1_Human1.08974841
107JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08796365
108NANOG_21062744_ChIP-ChIP_HESCs_Human1.08239185
109SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07804281
110DROSHA_22980978_ChIP-Seq_HELA_Human1.07679471
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.07215416
112TBX20_22328084_ChIP-Seq_HEART_Mouse1.07215416
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05764927
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05485201
115* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04678841
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04375860
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04352939
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03853005
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03662732
120* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03640064
121GATA4_21415370_ChIP-Seq_HL-1_Mouse1.03633179
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02490590
123TP53_16413492_ChIP-PET_HCT116_Human1.01780560
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00906844
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00562016
126CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00349655
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.00324832
128RUNX1_22412390_ChIP-Seq_EML_Mouse1.00221616
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99706953
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99683511
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99229337
132SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99085259
133* CREB1_26743006_Chip-Seq_LNCaP_Human0.98000847
134SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97985402
135* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97817884
136* VDR_24763502_ChIP-Seq_THP-1_Human0.97535463
137WT1_19549856_ChIP-ChIP_CCG9911_Human0.97515420
138SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97370198
139* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97297651
140* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97277762
141* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97272353
142* SPI1_23127762_ChIP-Seq_K562_Human0.92953266
143RXR_22108803_ChIP-Seq_LS180_Human0.92586400
144NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92213221
145SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92200834
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89481639
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88293670
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87437609
149IRF8_22096565_ChIP-ChIP_GC-B_Human0.86469276
150JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86403742
151FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84468341
152SMAD4_21799915_ChIP-Seq_A2780_Human0.83981874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo3.96534765
2MP0003303_peritoneal_inflammation3.80371139
3MP0002877_abnormal_melanocyte_morpholog3.65055405
4MP0008260_abnormal_autophagy3.51846786
5MP0004147_increased_porphyrin_level3.39371679
6MP0003705_abnormal_hypodermis_morpholog2.87460591
7MP0002009_preneoplasia2.60661595
8MP0001545_abnormal_hematopoietic_system2.36344827
9MP0005397_hematopoietic_system_phenotyp2.36344827
10MP0005076_abnormal_cell_differentiation2.29395913
11MP0003724_increased_susceptibility_to2.29320313
12MP0002396_abnormal_hematopoietic_system2.26317839
13MP0005409_darkened_coat_color2.22450779
14MP0003300_gastrointestinal_ulcer2.19312052
15MP0004084_abnormal_cardiac_muscle2.13391193
16MP0005451_abnormal_body_composition2.13171791
17MP0002332_abnormal_exercise_endurance2.13110210
18* MP0004808_abnormal_hematopoietic_stem2.05448618
19MP0010352_gastrointestinal_tract_polyps1.97400156
20MP0004264_abnormal_extraembryonic_tissu1.96020070
21MP0003172_abnormal_lysosome_physiology1.95470462
22MP0003091_abnormal_cell_migration1.83883165
23MP0004883_abnormal_blood_vessel1.69867093
24* MP0010307_abnormal_tumor_latency1.67693381
25MP0006054_spinal_hemorrhage1.64388225
26MP0003566_abnormal_cell_adhesion1.63134603
27MP0003690_abnormal_glial_cell1.62780414
28MP0002166_altered_tumor_susceptibility1.61221713
29MP0000015_abnormal_ear_pigmentation1.61068355
30MP0008877_abnormal_DNA_methylation1.57291509
31MP0005174_abnormal_tail_pigmentation1.56330729
32MP0003111_abnormal_nucleus_morphology1.56241691
33MP0001915_intracranial_hemorrhage1.55476971
34MP0010234_abnormal_vibrissa_follicle1.53921747
35MP0003787_abnormal_imprinting1.52187846
36MP0010630_abnormal_cardiac_muscle1.48516916
37MP0003329_amyloid_beta_deposits1.47970432
38MP0008007_abnormal_cellular_replicative1.45177383
39MP0003191_abnormal_cellular_cholesterol1.41031530
40MP0009278_abnormal_bone_marrow1.40356169
41MP0005248_abnormal_Harderian_gland1.40142292
42MP0003828_pulmonary_edema1.33654031
43MP0010094_abnormal_chromosome_stability1.33218791
44MP0003941_abnormal_skin_development1.33076785
45MP0004484_altered_response_of1.32743673
46MP0005164_abnormal_response_to1.31596135
47MP0003252_abnormal_bile_duct1.30957841
48MP0004381_abnormal_hair_follicle1.30396341
49MP0002086_abnormal_extraembryonic_tissu1.28919792
50MP0003943_abnormal_hepatobiliary_system1.28149691
51MP0004510_myositis1.27805983
52MP0000767_abnormal_smooth_muscle1.25818427
53MP0003077_abnormal_cell_cycle1.25445205
54MP0003567_abnormal_fetal_cardiomyocyte1.24962061
55MP0000350_abnormal_cell_proliferation1.22056151
56MP0010368_abnormal_lymphatic_system1.21490425
57MP0008004_abnormal_stomach_pH1.20828995
58MP0003984_embryonic_growth_retardation1.18426698
59MP0002088_abnormal_embryonic_growth/wei1.17650298
60MP0002971_abnormal_brown_adipose1.17349934
61MP0003221_abnormal_cardiomyocyte_apopto1.16188573
62MP0006138_congestive_heart_failure1.15690923
63MP0003045_fibrosis1.15212620
64MP0008961_abnormal_basal_metabolism1.14960279
65MP0005380_embryogenesis_phenotype1.14448290
66MP0001672_abnormal_embryogenesis/_devel1.14448290
67MP0008438_abnormal_cutaneous_collagen1.11641983
68MP0005464_abnormal_platelet_physiology1.11171215
69MP0005023_abnormal_wound_healing1.10497854
70MP0004197_abnormal_fetal_growth/weight/1.10372689
71MP0009780_abnormal_chondrocyte_physiolo1.10259343
72MP0003632_abnormal_nervous_system1.08238918
73MP0005666_abnormal_adipose_tissue1.07823351
74MP0005275_abnormal_skin_tensile1.07162781
75MP0000266_abnormal_heart_morphology1.06606775
76MP0002006_tumorigenesis1.03913218
77MP0004782_abnormal_surfactant_physiolog1.02396981
78MP0005187_abnormal_penis_morphology1.02307235
79MP0001544_abnormal_cardiovascular_syste1.01291406
80MP0005385_cardiovascular_system_phenoty1.01291406
81MP0003115_abnormal_respiratory_system1.00672660
82MP0008775_abnormal_heart_ventricle0.99749594
83MP0002925_abnormal_cardiovascular_devel0.98990024
84MP0003879_abnormal_hair_cell0.98284098
85MP0004087_abnormal_muscle_fiber0.97939775
86MP0003631_nervous_system_phenotype0.97288040
87MP0001697_abnormal_embryo_size0.97227403
88MP0000490_abnormal_crypts_of0.96735877
89MP0005375_adipose_tissue_phenotype0.95065406
90MP0000383_abnormal_hair_follicle0.94676319
91* MP0004947_skin_inflammation0.94283727
92MP0002139_abnormal_hepatobiliary_system0.93516923
93MP0004036_abnormal_muscle_relaxation0.92083767
94MP0001849_ear_inflammation0.91816548
95MP0002998_abnormal_bone_remodeling0.91706452
96MP0003279_aneurysm0.91669779
97MP0000604_amyloidosis0.91202830
98MP0000733_abnormal_muscle_development0.90834244
99MP0009053_abnormal_anal_canal0.90637674
100MP0005367_renal/urinary_system_phenotyp0.89827220
101MP0000516_abnormal_urinary_system0.89827220
102MP0001958_emphysema0.88713641
103MP0002084_abnormal_developmental_patter0.88585287
104MP0001440_abnormal_grooming_behavior0.88430502
105* MP0001119_abnormal_female_reproductive0.87798926
106MP0004885_abnormal_endolymph0.87676744
107MP0002108_abnormal_muscle_morphology0.87581490
108* MP0003699_abnormal_female_reproductive0.87518194
109MP0005388_respiratory_system_phenotype0.87473750
110MP0002133_abnormal_respiratory_system0.87473750
111MP0003646_muscle_fatigue0.86669295
112MP0003633_abnormal_nervous_system0.86323440
113MP0000569_abnormal_digit_pigmentation0.86263574
114MP0004130_abnormal_muscle_cell0.85993755
115MP0001851_eye_inflammation0.85551701
116MP0002928_abnormal_bile_duct0.84886308
117MP0002060_abnormal_skin_morphology0.83948027
118MP0005647_abnormal_sex_gland0.83519561
119MP0005408_hypopigmentation0.83195747
120* MP0000313_abnormal_cell_death0.82916818
121MP0005083_abnormal_biliary_tract0.82583905
122MP0002168_other_aberrant_phenotype0.81928484
123MP0002128_abnormal_blood_circulation0.81693035
124MP0010678_abnormal_skin_adnexa0.81464945
125MP0002653_abnormal_ependyma_morphology0.81281215
126MP0005595_abnormal_vascular_smooth0.79104459
127MP0000749_muscle_degeneration0.78725560
128MP0000371_diluted_coat_color0.78445662
129MP0003634_abnormal_glial_cell0.78419947
130MP0003453_abnormal_keratinocyte_physiol0.78218923
131MP0003436_decreased_susceptibility_to0.77881374
132MP0009703_decreased_birth_body0.77035028
133MP0000534_abnormal_ureter_morphology0.76881475
134MP0002085_abnormal_embryonic_tissue0.75885284
135MP0000609_abnormal_liver_physiology0.75349872
136* MP0002019_abnormal_tumor_incidence0.74707680
137MP0005621_abnormal_cell_physiology0.74660172
138MP0009384_cardiac_valve_regurgitation0.74588487
139MP0000598_abnormal_liver_morphology0.74322868
140MP0005503_abnormal_tendon_morphology0.73925143
141MP0001175_abnormal_lung_morphology0.73380619
142MP0002972_abnormal_cardiac_muscle0.73157304
143* MP0002398_abnormal_bone_marrow0.73033381
144MP0001784_abnormal_fluid_regulation0.72868336
145MP0005620_abnormal_muscle_contractility0.72514595
146MP0000759_abnormal_skeletal_muscle0.72474101
147MP0002269_muscular_atrophy0.71444414
148MP0002419_abnormal_innate_immunity0.70954286
149MP0001502_abnormal_circadian_rhythm0.69539792
150MP0009115_abnormal_fat_cell0.68772782
151MP0002822_catalepsy0.64572315
152MP0000465_gastrointestinal_hemorrhage0.62381686
153MP0004185_abnormal_adipocyte_glucose0.62197432
154MP0001501_abnormal_sleep_pattern0.59660704
155MP0003075_altered_response_to0.58234999
156MP0004043_abnormal_pH_regulation0.57484706
157MP0003763_abnormal_thymus_physiology0.56488598
158MP0000685_abnormal_immune_system0.55866850
159MP0005025_abnormal_response_to0.55059226
160MP0000249_abnormal_blood_vessel0.54513572
161MP0001664_abnormal_digestion0.54292435
162MP0005167_abnormal_blood-brain_barrier0.54154449

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)5.13176590
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.69961435
3Abnormality of the fingertips (HP:0001211)4.54626924
4Abnormality of the heme biosynthetic pathway (HP:0010472)3.65649207
5Hypochromic microcytic anemia (HP:0004840)3.52862589
6Dysmetric saccades (HP:0000641)3.35640464
7Acanthocytosis (HP:0001927)3.06163200
8Enlarged penis (HP:0000040)2.97310448
9Slow saccadic eye movements (HP:0000514)2.95889135
10Papillary thyroid carcinoma (HP:0002895)2.94704973
11Postural instability (HP:0002172)2.93565823
12Obstructive sleep apnea (HP:0002870)2.87175609
13Cerebral inclusion bodies (HP:0100314)2.82552019
14Reticulocytosis (HP:0001923)2.79865800
15Peritonitis (HP:0002586)2.71190930
16Lip pit (HP:0100267)2.69189371
17Long eyelashes (HP:0000527)2.63617968
18Acute myeloid leukemia (HP:0004808)2.62714208
19Abnormality of incisor morphology (HP:0011063)2.61467343
20Visual hallucinations (HP:0002367)2.57521201
21Difficulty running (HP:0009046)2.54134582
22Microcytic anemia (HP:0001935)2.52075195
23Gastrointestinal infarctions (HP:0005244)2.51357793
24Diaphragmatic weakness (HP:0009113)2.45055511
25Broad palm (HP:0001169)2.44023806
26Aortic aneurysm (HP:0004942)2.41408210
27Hyperkalemia (HP:0002153)2.41071874
28Overgrowth (HP:0001548)2.39995078
29Recurrent bacterial skin infections (HP:0005406)2.38030345
30Spinal cord lesions (HP:0100561)2.33398331
31Syringomyelia (HP:0003396)2.33398331
32Macroorchidism (HP:0000053)2.32368336
33Eczematoid dermatitis (HP:0000976)2.31276932
34Gingival bleeding (HP:0000225)2.29052455
35Ankle contracture (HP:0006466)2.27965109
36Deep philtrum (HP:0002002)2.27312721
37Narrow palate (HP:0000189)2.25285983
38Muscle fiber splitting (HP:0003555)2.22961971
39Gingivitis (HP:0000230)2.22651552
40Thyroid carcinoma (HP:0002890)2.21802218
41Bundle branch block (HP:0011710)2.18840486
42Spontaneous hematomas (HP:0007420)2.14008840
43Shawl scrotum (HP:0000049)2.13940523
44Polycythemia (HP:0001901)2.13509147
45Hematochezia (HP:0002573)2.11513915
46Optic neuritis (HP:0100653)2.10489725
47Retrobulbar optic neuritis (HP:0100654)2.10489725
48Arterial tortuosity (HP:0005116)2.09753797
49Orchitis (HP:0100796)2.09389618
50Vascular tortuosity (HP:0004948)2.08122545
51Absent frontal sinuses (HP:0002688)2.05514688
52Hyporeflexia of lower limbs (HP:0002600)2.05235904
53Rectal prolapse (HP:0002035)2.03727925
54Cerebral aneurysm (HP:0004944)2.03690897
55Febrile seizures (HP:0002373)2.03651638
56Depressed nasal tip (HP:0000437)2.03624135
57Hyperacusis (HP:0010780)2.03251629
58Cholelithiasis (HP:0001081)2.02961242
59Progressive cerebellar ataxia (HP:0002073)1.99669860
60Neonatal hypoglycemia (HP:0001998)1.96942156
61Insomnia (HP:0100785)1.96622535
62Heterotopia (HP:0002282)1.96167329
63Subacute progressive viral hepatitis (HP:0006572)1.95886802
64Abnormality of the nasal septum (HP:0000419)1.92549097
65Shallow orbits (HP:0000586)1.92213112
66Aneurysm (HP:0002617)1.90022491
67Osteomalacia (HP:0002749)1.89719401
68Increased variability in muscle fiber diameter (HP:0003557)1.89581564
69Facial diplegia (HP:0001349)1.89002118
70Prominent nose (HP:0000448)1.87956507
71Urethral obstruction (HP:0000796)1.86030084
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85291923
73Short 4th metacarpal (HP:0010044)1.85291923
74Recurrent abscess formation (HP:0002722)1.84792327
75Abnormality of the left ventricular outflow tract (HP:0011103)1.84594967
76Subaortic stenosis (HP:0001682)1.84594967
77Osteolytic defects of the hand bones (HP:0009699)1.84592877
78Osteolytic defects of the phalanges of the hand (HP:0009771)1.84592877
79Renovascular hypertension (HP:0100817)1.84275802
80Keratoconjunctivitis sicca (HP:0001097)1.82738904
81Right ventricular cardiomyopathy (HP:0011663)1.82368865
82Bilateral sensorineural hearing impairment (HP:0008619)1.81358816
83Male infertility (HP:0003251)1.80938713
84Prolonged bleeding time (HP:0003010)1.80228383
85Broad metatarsal (HP:0001783)1.79988684
86Atrial fibrillation (HP:0005110)1.78266528
87Myositis (HP:0100614)1.77048808
88Hepatocellular carcinoma (HP:0001402)1.75677982
89Neoplasm of the oral cavity (HP:0100649)1.75293044
90Truncal obesity (HP:0001956)1.75037386
91Mitral valve prolapse (HP:0001634)1.74954152
92Recurrent gram-negative bacterial infections (HP:0005420)1.74505226
93Hyperbilirubinemia (HP:0002904)1.74416246
94Cutaneous melanoma (HP:0012056)1.74057692
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.72898349
96Mask-like facies (HP:0000298)1.71456987
97Increased connective tissue (HP:0009025)1.70662362
98Abnormality of the radial head (HP:0003995)1.69673427
99Tapered finger (HP:0001182)1.69524360
100Hypochromic anemia (HP:0001931)1.69510924
101Sandal gap (HP:0001852)1.67922678
102Neoplasm of the adrenal cortex (HP:0100641)1.67799421
103Trigonocephaly (HP:0000243)1.67378218
104Asymmetry of the thorax (HP:0001555)1.67198306
105Urinary bladder sphincter dysfunction (HP:0002839)1.67111389
106Hyperventilation (HP:0002883)1.66900275
107Transitional cell carcinoma of the bladder (HP:0006740)1.66405712
108Ventricular tachycardia (HP:0004756)1.65838740
109Periodontitis (HP:0000704)1.65798535
110Long toe (HP:0010511)1.65583863
111Subcapsular cataract (HP:0000523)1.63666241
112High pitched voice (HP:0001620)1.63650612
113Abnormal gallbladder morphology (HP:0012437)1.63277271
114Renal tubular acidosis (HP:0001947)1.62741443
115Spondylolisthesis (HP:0003302)1.62010179
116Genetic anticipation (HP:0003743)1.61292351
117Protrusio acetabuli (HP:0003179)1.59261884
118Hyperglycemia (HP:0003074)1.58203555
119Dislocated radial head (HP:0003083)1.58196040
120Posterior subcapsular cataract (HP:0007787)1.58150154
121Myocardial infarction (HP:0001658)1.57981473
122Decreased motor nerve conduction velocity (HP:0003431)1.57829719
123Metaphyseal cupping (HP:0003021)1.57604472
124Hypoplasia of the iris (HP:0007676)1.56515508
125Elfin facies (HP:0004428)1.56407375
126Abnormality of the 4th metacarpal (HP:0010012)1.56374698
127Ankle clonus (HP:0011448)1.56004632
128Primary atrial arrhythmia (HP:0001692)1.55113712
129Laryngomalacia (HP:0001601)1.54947583
130Epistaxis (HP:0000421)1.54721023
131Volvulus (HP:0002580)1.54024248
132Hypoplastic labia majora (HP:0000059)1.53512951
133Impaired platelet aggregation (HP:0003540)1.53444202
134Abnormal platelet function (HP:0011869)1.53444202
135Widely spaced teeth (HP:0000687)1.53379828
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53168567
137Abnormality of skeletal muscle fiber size (HP:0012084)1.52505452
138Childhood onset (HP:0011463)1.51518681
139Lymphangioma (HP:0100764)1.51510494
140Bladder carcinoma (HP:0002862)1.51390798
141Bladder neoplasm (HP:0009725)1.51390798
142Abnormality of the ischium (HP:0003174)1.51227107
143Onion bulb formation (HP:0003383)1.50975839
144Keratoconjunctivitis (HP:0001096)1.50482522
145Abnormal hair whorl (HP:0010721)1.50416363
146Abnormality of the labia majora (HP:0012881)1.49899918
147Germ cell neoplasia (HP:0100728)1.49246155
148Papilledema (HP:0001085)1.49214483
149Abnormality of saccadic eye movements (HP:0000570)1.48674733
150Testicular neoplasm (HP:0010788)1.47507158
151Pseudobulbar signs (HP:0002200)1.47434469
152Striae distensae (HP:0001065)1.46689264
153Large earlobe (HP:0009748)1.46586335
154Hypoplastic ischia (HP:0003175)1.46218418
155Pendular nystagmus (HP:0012043)1.45554397
156Curly hair (HP:0002212)1.45465294
157Cystic hygroma (HP:0000476)1.45425257
158Pigmentary retinal degeneration (HP:0001146)1.45277292
159Acute lymphatic leukemia (HP:0006721)1.45202626
160Truncal ataxia (HP:0002078)1.44638268
161Cubitus valgus (HP:0002967)1.44565284
162Coarse hair (HP:0002208)1.44361792
163Gastrointestinal carcinoma (HP:0002672)1.44229634
164Type 1 muscle fiber predominance (HP:0003803)1.44168525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.94108359
2CDK123.92649959
3LATS13.84218468
4PKN22.55663875
5WNK12.50720989
6RIPK12.36624771
7MAP3K32.17795475
8TRIB32.16606789
9MARK21.97324253
10TAOK31.94623340
11SIK11.88907882
12FGFR31.86938930
13STK31.84749630
14STK38L1.73614522
15MAP3K21.68988118
16FRK1.64976767
17TRPM71.61737965
18ZAK1.61443402
19CDK61.54553802
20FGR1.52341303
21STK241.52202553
22FLT31.52040065
23GRK61.48746154
24PTK2B1.46144192
25MAP3K11.44222040
26DMPK1.41274186
27CDK91.41183301
28BLK1.40061176
29MAPKAPK31.39535487
30* SGK31.38494984
31RIPK41.32472809
32TAOK11.31434213
33PDGFRA1.30070125
34CAMK1D1.29502188
35AKT31.27261854
36RPS6KB21.26999198
37* SGK2231.24138260
38* SGK4941.24138260
39BRD41.21788192
40IRAK11.21610490
41TGFBR21.21505680
42IRAK21.21358996
43GRK51.21208589
44NEK91.20899891
45NEK21.19587236
46KSR11.18496622
47NLK1.16916226
48MAP3K101.16809668
49TTN1.13338994
50TAOK21.08771102
51PRKAA11.08018506
52CDC71.07489134
53PIK3CG1.07109839
54KSR21.06339522
55NEK11.05887038
56* SGK21.04923435
57DYRK1A1.03324374
58MTOR1.02020069
59STK111.01556403
60CSK1.00527720
61DAPK20.97890860
62CDK40.97765825
63LATS20.97660804
64NTRK30.97456978
65STK380.95915265
66PTK60.93252036
67LMTK20.92499741
68YES10.89782149
69* CHUK0.86894307
70MAP3K130.85861887
71* PIM10.85430154
72PDGFRB0.84814427
73* SGK10.82551267
74ICK0.80723543
75MAP3K60.80628424
76MAPK70.80441201
77RET0.80307794
78JAK20.80167652
79MAPK120.80079845
80PLK20.79873947
81PRPF4B0.79734686
82BRSK20.78719127
83STK100.77589896
84SCYL20.77150876
85MAP3K110.76339441
86PAK30.76007072
87EPHB10.74787144
88CDC42BPA0.73918253
89MATK0.73023607
90CAMKK20.73011219
91RPS6KB10.72444460
92CAMK10.72338351
93IRAK40.72088205
94TTK0.70829416
95PRKD20.70659209
96JAK10.70026627
97ERBB20.69396506
98BMX0.68238395
99CAMK40.67455928
100SYK0.66793669
101EPHA30.66493821
102HCK0.66244940
103RPS6KA60.65386219
104MKNK20.64737483
105HIPK20.64484534
106PRKCH0.63697639
107DYRK1B0.63362220
108MAP2K30.63286455
109MARK30.62721809
110MARK10.62538175
111RPS6KC10.62440024
112RPS6KL10.62440024
113CAMK1G0.61133292
114RPS6KA20.61078373
115TNK20.61040616
116MKNK10.60960313
117CHEK20.60639569
118ATM0.59727619
119ERN10.59660045
120PAK40.58583065
121MAPK110.58042183
122FES0.56829886
123OBSCN0.56604981
124EPHA20.56531941
125RAF10.56072988
126CDK70.55858285
127JAK30.55692942
128MAP3K70.55105745
129MAP3K140.54072612
130MAP2K40.53719980
131MAP3K50.52914684
132PDK10.52484063
133ATR0.52136695
134ALK0.51324153
135MOS0.51190600
136ZAP700.51187883
137PINK10.51030797
138NUAK10.50470084
139MUSK0.50100581
140* AKT10.49589167
141* STK40.48222394
142TYK20.46780345
143PIK3CA0.46434145
144* MAPK140.46385348
145KIT0.45923639
146MELK0.45562101
147PDPK10.45381982
148CAMKK10.45376797
149CDK20.45353294
150CDK80.45197527
151RPS6KA10.45112749
152MAP4K10.43888660
153MAPK80.43525486
154* MAPK10.43418342

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.03326642
2Chronic myeloid leukemia_Homo sapiens_hsa052201.84750834
3Thyroid hormone signaling pathway_Homo sapiens_hsa049191.61023197
4mTOR signaling pathway_Homo sapiens_hsa041501.52135180
5Pancreatic cancer_Homo sapiens_hsa052121.49932278
6Malaria_Homo sapiens_hsa051441.49720022
7MicroRNAs in cancer_Homo sapiens_hsa052061.49121605
8Small cell lung cancer_Homo sapiens_hsa052221.47500092
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47190277
10Nitrogen metabolism_Homo sapiens_hsa009101.44377527
11Notch signaling pathway_Homo sapiens_hsa043301.38269330
12Adherens junction_Homo sapiens_hsa045201.38191379
13Long-term potentiation_Homo sapiens_hsa047201.37229497
14Cell cycle_Homo sapiens_hsa041101.31623086
15Thyroid cancer_Homo sapiens_hsa052161.29786589
16Insulin resistance_Homo sapiens_hsa049311.27996922
17B cell receptor signaling pathway_Homo sapiens_hsa046621.26247815
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25976310
19Systemic lupus erythematosus_Homo sapiens_hsa053221.25221047
20p53 signaling pathway_Homo sapiens_hsa041151.25144642
21VEGF signaling pathway_Homo sapiens_hsa043701.23460278
22Dorso-ventral axis formation_Homo sapiens_hsa043201.21806971
23* Non-small cell lung cancer_Homo sapiens_hsa052231.20207995
24Glioma_Homo sapiens_hsa052141.19999128
25Acute myeloid leukemia_Homo sapiens_hsa052211.19470207
26GnRH signaling pathway_Homo sapiens_hsa049121.18801078
27ABC transporters_Homo sapiens_hsa020101.18357830
28* Endometrial cancer_Homo sapiens_hsa052131.17963036
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15090409
30Selenocompound metabolism_Homo sapiens_hsa004501.13774248
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.13511231
32* FoxO signaling pathway_Homo sapiens_hsa040681.10917702
33Platelet activation_Homo sapiens_hsa046111.08611455
34Circadian rhythm_Homo sapiens_hsa047101.08564195
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08395758
36* Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08387540
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07695001
38TNF signaling pathway_Homo sapiens_hsa046681.05648592
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05631563
40Prostate cancer_Homo sapiens_hsa052151.05426455
41Focal adhesion_Homo sapiens_hsa045101.04503717
42* Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04111523
43* Prolactin signaling pathway_Homo sapiens_hsa049171.03810404
44Inositol phosphate metabolism_Homo sapiens_hsa005621.01544504
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01212801
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00909882
47Dilated cardiomyopathy_Homo sapiens_hsa054141.00469393
48Caffeine metabolism_Homo sapiens_hsa002321.00200227
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99347101
50Proteoglycans in cancer_Homo sapiens_hsa052050.96826294
51Hepatitis C_Homo sapiens_hsa051600.95253473
52Bladder cancer_Homo sapiens_hsa052190.95082228
53Insulin signaling pathway_Homo sapiens_hsa049100.94953383
54Viral carcinogenesis_Homo sapiens_hsa052030.94820531
55Leishmaniasis_Homo sapiens_hsa051400.93567299
56T cell receptor signaling pathway_Homo sapiens_hsa046600.92282544
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91994083
58Type II diabetes mellitus_Homo sapiens_hsa049300.91853777
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91685668
60Tuberculosis_Homo sapiens_hsa051520.91353372
61TGF-beta signaling pathway_Homo sapiens_hsa043500.91039500
62Toxoplasmosis_Homo sapiens_hsa051450.90947325
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90361162
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89620618
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88712729
66Oxytocin signaling pathway_Homo sapiens_hsa049210.88651128
67Colorectal cancer_Homo sapiens_hsa052100.88559139
68MAPK signaling pathway_Homo sapiens_hsa040100.88460179
69Long-term depression_Homo sapiens_hsa047300.88432138
70Renin secretion_Homo sapiens_hsa049240.85853980
71* Chemokine signaling pathway_Homo sapiens_hsa040620.85239213
72ECM-receptor interaction_Homo sapiens_hsa045120.84601748
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84263785
74Cholinergic synapse_Homo sapiens_hsa047250.84148165
75Apoptosis_Homo sapiens_hsa042100.82403318
76Hepatitis B_Homo sapiens_hsa051610.82058145
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.80933541
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80684265
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79599188
80Bile secretion_Homo sapiens_hsa049760.79056942
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78234411
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.77084354
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.76286402
84Melanoma_Homo sapiens_hsa052180.76210116
85* Neurotrophin signaling pathway_Homo sapiens_hsa047220.74983541
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74670316
87* AMPK signaling pathway_Homo sapiens_hsa041520.73982460
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73950573
89African trypanosomiasis_Homo sapiens_hsa051430.73726449
90Rap1 signaling pathway_Homo sapiens_hsa040150.73365201
91Ovarian steroidogenesis_Homo sapiens_hsa049130.72179005
92HTLV-I infection_Homo sapiens_hsa051660.71600621
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.71149163
94Amoebiasis_Homo sapiens_hsa051460.70682895
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70486229
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.69448488
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68868103
98Circadian entrainment_Homo sapiens_hsa047130.68473471
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68434006
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67913254
101Glucagon signaling pathway_Homo sapiens_hsa049220.67743630
102Glutamatergic synapse_Homo sapiens_hsa047240.67204185
103mRNA surveillance pathway_Homo sapiens_hsa030150.66049510
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65109364
105Fatty acid degradation_Homo sapiens_hsa000710.64671761
106Herpes simplex infection_Homo sapiens_hsa051680.64664872
107Gap junction_Homo sapiens_hsa045400.64625609
108Hippo signaling pathway_Homo sapiens_hsa043900.64572489
109Amphetamine addiction_Homo sapiens_hsa050310.64344569
110Estrogen signaling pathway_Homo sapiens_hsa049150.63782065
111Pathways in cancer_Homo sapiens_hsa052000.63473275
112Choline metabolism in cancer_Homo sapiens_hsa052310.63243813
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.62865712
114Pancreatic secretion_Homo sapiens_hsa049720.62721356
115Gastric acid secretion_Homo sapiens_hsa049710.62654362
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62082468
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61653838
118Influenza A_Homo sapiens_hsa051640.61019401
119Ras signaling pathway_Homo sapiens_hsa040140.60852611
120Alcoholism_Homo sapiens_hsa050340.60681988
121HIF-1 signaling pathway_Homo sapiens_hsa040660.58520592
122Starch and sucrose metabolism_Homo sapiens_hsa005000.57075056
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54399485
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53466346
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52347112
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51841585
127Viral myocarditis_Homo sapiens_hsa054160.50651192
128ErbB signaling pathway_Homo sapiens_hsa040120.50485048
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50206129
130Protein digestion and absorption_Homo sapiens_hsa049740.49981532
131Arginine biosynthesis_Homo sapiens_hsa002200.49653899
132cAMP signaling pathway_Homo sapiens_hsa040240.49096379
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.48657400
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47406642
135Renal cell carcinoma_Homo sapiens_hsa052110.45061839
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43257816
137Osteoclast differentiation_Homo sapiens_hsa043800.43101550
138Measles_Homo sapiens_hsa051620.42614309

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