FOXP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.73765618
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.85592800
3positive regulation of gamma-delta T cell activation (GO:0046645)4.66377868
4positive T cell selection (GO:0043368)4.18971157
5B cell receptor signaling pathway (GO:0050853)4.18606186
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.10578369
7negative regulation of cell killing (GO:0031342)4.02836934
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02836934
9regulation of B cell receptor signaling pathway (GO:0050855)4.01857003
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.97680713
11negative regulation of cytosolic calcium ion concentration (GO:0051481)3.89658882
12membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.80540835
13primary amino compound metabolic process (GO:1901160)3.68262977
14cell proliferation in forebrain (GO:0021846)3.65160867
15activated T cell proliferation (GO:0050798)3.59319548
16cellular response to interleukin-15 (GO:0071350)3.51221433
17T cell selection (GO:0045058)3.48065247
18water-soluble vitamin biosynthetic process (GO:0042364)3.43192642
19membrane repolarization during action potential (GO:0086011)3.42215897
20regulation of gamma-delta T cell differentiation (GO:0045586)3.38939031
21cAMP catabolic process (GO:0006198)3.38786269
22negative T cell selection (GO:0043383)3.37473944
23negative thymic T cell selection (GO:0045060)3.36327393
24indolalkylamine metabolic process (GO:0006586)3.32976289
25response to interleukin-15 (GO:0070672)3.32475559
26positive thymic T cell selection (GO:0045059)3.29797341
27neuronal action potential (GO:0019228)3.25381815
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22719112
29adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.21682805
30gamma-aminobutyric acid transport (GO:0015812)3.21315334
31positive regulation of fatty acid beta-oxidation (GO:0032000)3.21223584
32sulfation (GO:0051923)3.18097423
33negative regulation of appetite (GO:0032099)3.14625476
34negative regulation of response to food (GO:0032096)3.14625476
35regulation of gamma-delta T cell activation (GO:0046643)3.13841624
36ovulation cycle (GO:0042698)3.12800965
37membrane depolarization during action potential (GO:0086010)3.10810283
38kidney morphogenesis (GO:0060993)3.09072973
39definitive hemopoiesis (GO:0060216)3.07311629
40positive regulation of granulocyte differentiation (GO:0030854)3.04236287
41behavioral response to ethanol (GO:0048149)2.99835438
42transmission of nerve impulse (GO:0019226)2.98309884
43regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.98153069
44mast cell activation (GO:0045576)2.96351169
45B cell proliferation (GO:0042100)2.95832792
46cyclic nucleotide catabolic process (GO:0009214)2.94732346
47negative regulation of phagocytosis (GO:0050765)2.94404188
48endoderm formation (GO:0001706)2.94371521
49positive regulation of fatty acid oxidation (GO:0046321)2.92962539
50negative regulation of systemic arterial blood pressure (GO:0003085)2.92654195
51mast cell degranulation (GO:0043303)2.92172823
52mast cell activation involved in immune response (GO:0002279)2.92172823
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.90740038
54positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.89880589
55antigen receptor-mediated signaling pathway (GO:0050851)2.89749556
56somite development (GO:0061053)2.89454838
57T cell homeostasis (GO:0043029)2.88305349
58DNA deamination (GO:0045006)2.88249994
59germinal center formation (GO:0002467)2.88074420
60regulation of interleukin-12 biosynthetic process (GO:0045075)2.82313635
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.81513823
62regulation of B cell differentiation (GO:0045577)2.81155174
63* V(D)J recombination (GO:0033151)2.80352654
64myeloid dendritic cell activation (GO:0001773)2.79219863
65regulation of regulatory T cell differentiation (GO:0045589)2.77877615
66mature B cell differentiation (GO:0002335)2.76250291
67histone H3-K4 trimethylation (GO:0080182)2.75525840
68indole-containing compound metabolic process (GO:0042430)2.75191665
69dendritic spine morphogenesis (GO:0060997)2.74557417
70response to amphetamine (GO:0001975)2.73969532
71thymic T cell selection (GO:0045061)2.72932801
72negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72322933
73regulation of non-canonical Wnt signaling pathway (GO:2000050)2.71992903
74synaptic transmission, dopaminergic (GO:0001963)2.71707970
75positive regulation of B cell differentiation (GO:0045579)2.70746297
76positive regulation of fatty acid transport (GO:2000193)2.69557895
77magnesium ion transport (GO:0015693)2.68750957
78interkinetic nuclear migration (GO:0022027)2.67885558
79histamine secretion (GO:0001821)2.67286851
80cellular response to ATP (GO:0071318)2.67244248
81nephron epithelium morphogenesis (GO:0072088)2.66089340
82nephron tubule morphogenesis (GO:0072078)2.66089340
83cellular response to exogenous dsRNA (GO:0071360)2.65976814
84antigen processing and presentation of endogenous antigen (GO:0019883)2.65548159
85synaptic transmission, cholinergic (GO:0007271)2.63535652
86lymph vessel development (GO:0001945)2.62683863
87lymphocyte homeostasis (GO:0002260)2.61872011
88otic vesicle formation (GO:0030916)2.61722077
89regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.61538455
90detection of light stimulus involved in visual perception (GO:0050908)2.61291172
91detection of light stimulus involved in sensory perception (GO:0050962)2.61291172
92negative regulation of cAMP-mediated signaling (GO:0043951)2.59732707
93interferon-gamma production (GO:0032609)2.59632325
94epithelial cilium movement (GO:0003351)2.59082926
95parturition (GO:0007567)2.58607686
96protein polyglutamylation (GO:0018095)2.57797224
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57750867
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.57750867
99NADH dehydrogenase complex assembly (GO:0010257)2.57750867
100negative regulation of T cell differentiation in thymus (GO:0033085)2.57362324
101regulation of rhodopsin mediated signaling pathway (GO:0022400)2.56518401
102spinal cord motor neuron differentiation (GO:0021522)2.55564502
103regulation of membrane repolarization (GO:0060306)2.54849657
104megakaryocyte development (GO:0035855)2.54524792
105protein complex biogenesis (GO:0070271)2.54166418
106positive regulation of cAMP-mediated signaling (GO:0043950)2.53858163
107dentate gyrus development (GO:0021542)2.53836416
108axoneme assembly (GO:0035082)2.53190959
109adaptation of signaling pathway (GO:0023058)2.53011538
110regulation of female receptivity (GO:0045924)2.52194770
111retinal ganglion cell axon guidance (GO:0031290)2.51895075
112T cell migration (GO:0072678)2.50883091
113regulation of mesoderm development (GO:2000380)2.50629271
114T cell receptor signaling pathway (GO:0050852)2.48339131
115monocyte differentiation (GO:0030224)2.47555971
116regulation of T cell tolerance induction (GO:0002664)2.46307290
117fucose catabolic process (GO:0019317)2.45579669
118L-fucose metabolic process (GO:0042354)2.45579669
119L-fucose catabolic process (GO:0042355)2.45579669
120regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.45116075
121rhodopsin mediated signaling pathway (GO:0016056)2.44668259
122regulation of action potential (GO:0098900)2.44624431
123positive regulation of neurotransmitter secretion (GO:0001956)2.43028896
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.42785906
125antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42785906
126cellular anion homeostasis (GO:0030002)2.42762248
127phosphorelay signal transduction system (GO:0000160)2.42723285
128positive regulation of B cell proliferation (GO:0030890)2.41340604
129B cell homeostasis (GO:0001782)2.41032002
130regulation of B cell proliferation (GO:0030888)2.40558299
131regulation of DNA endoreduplication (GO:0032875)2.40454797
132positive regulation of defense response to virus by host (GO:0002230)2.40382504
133action potential (GO:0001508)2.39983613
134pyrimidine nucleobase catabolic process (GO:0006208)2.39844744
135response to pheromone (GO:0019236)2.38974107
136cilium movement (GO:0003341)2.38026396
137positive regulation of icosanoid secretion (GO:0032305)2.37695687
138germ cell migration (GO:0008354)2.37542409
139membrane repolarization (GO:0086009)2.37442991
140positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.36837926
141positive regulation of potassium ion transmembrane transport (GO:1901381)2.36392915
142regulation of Rap GTPase activity (GO:0032317)2.36301383
143myeloid dendritic cell differentiation (GO:0043011)2.35762536
144dopaminergic neuron differentiation (GO:0071542)2.34351064
145immune response-activating cell surface receptor signaling pathway (GO:0002429)2.32651002
146long-term synaptic potentiation (GO:0060291)2.32647670
147hepatocyte apoptotic process (GO:0097284)2.32094230
148multicellular organismal signaling (GO:0035637)2.30071520
149lymphocyte proliferation (GO:0046651)2.29658677
150negative regulation of T cell mediated immunity (GO:0002710)2.29057731
151thyroid hormone metabolic process (GO:0042403)2.28502361
152mononuclear cell proliferation (GO:0032943)2.28429807
153reflex (GO:0060004)2.27971536
154leukocyte homeostasis (GO:0001776)2.27921937
155dopamine receptor signaling pathway (GO:0007212)2.26705239
156regulation of T cell receptor signaling pathway (GO:0050856)2.26528441
157regulation of calcium ion-dependent exocytosis (GO:0017158)2.26528168
158regulation of glomerulus development (GO:0090192)2.26402802
159positive regulation of action potential (GO:0045760)2.26223689
160positive regulation of meiosis (GO:0045836)2.26188620
161T cell differentiation (GO:0030217)2.25887820
162positive regulation of oligodendrocyte differentiation (GO:0048714)2.25307448
163CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.25172090
164angiogenesis involved in wound healing (GO:0060055)2.25084077
165T cell proliferation (GO:0042098)2.24861993
166lymph node development (GO:0048535)2.24589399
167tolerance induction (GO:0002507)2.24056508
168cerebellar Purkinje cell differentiation (GO:0021702)2.23609425
169positive regulation of interleukin-2 production (GO:0032743)2.23579934
170regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.22727879
171negative regulation of T cell differentiation (GO:0045581)2.22261934
172limb development (GO:0060173)2.21826390
173appendage development (GO:0048736)2.21826390
174serotonin metabolic process (GO:0042428)2.20863996
175positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.20360160
176regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.20360160
177regulation of sequestering of triglyceride (GO:0010889)2.20345184
178mitochondrial respiratory chain complex assembly (GO:0033108)2.20179280
179negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.19722712
180regulation of glutamate secretion (GO:0014048)2.16979939
181cAMP metabolic process (GO:0046058)2.16581610
182regulation of alpha-beta T cell proliferation (GO:0046640)2.16183039
183regulation of dendritic cell antigen processing and presentation (GO:0002604)2.15508278
184regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.15078485
185T cell costimulation (GO:0031295)2.13584270
186lymphocyte costimulation (GO:0031294)2.13545392
187SMAD protein complex assembly (GO:0007183)2.12466522
188leukocyte aggregation (GO:0070486)2.11952249
189modulation by virus of host process (GO:0019054)2.11938475
190defense response to protozoan (GO:0042832)2.11403631
191mRNA splice site selection (GO:0006376)2.09975779
192* B cell activation (GO:0042113)2.09125725
193alpha-beta T cell differentiation (GO:0046632)2.09039334
194regulation of isotype switching to IgG isotypes (GO:0048302)2.08195500
195leukocyte proliferation (GO:0070661)2.07202319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.63973899
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.39442016
3VDR_22108803_ChIP-Seq_LS180_Human2.75132682
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67548195
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.63942548
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.60843777
7EZH2_22144423_ChIP-Seq_EOC_Human2.59540487
8GBX2_23144817_ChIP-Seq_PC3_Human2.50012143
9* RUNX_20019798_ChIP-Seq_JUKART_Human2.47854575
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39151787
11* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34727593
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32179261
13ZNF274_21170338_ChIP-Seq_K562_Hela2.30395220
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.24496609
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23853571
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.10796802
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.09803823
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05974235
19* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04719557
20TAF15_26573619_Chip-Seq_HEK293_Human2.02958957
21* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99170206
22SCL_19346495_ChIP-Seq_HPC-7_Human1.90805852
23* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90314717
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89179786
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88444563
26MYC_22102868_ChIP-Seq_BL_Human1.79745220
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76874597
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.70053607
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69254401
30AR_21572438_ChIP-Seq_LNCaP_Human1.65498051
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63838104
32* MYB_26560356_Chip-Seq_TH2_Human1.63748068
33RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.63407357
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61297544
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60725703
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.59634011
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.56039968
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55067776
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.55013330
40BCAT_22108803_ChIP-Seq_LS180_Human1.54690979
41* REST_21632747_ChIP-Seq_MESCs_Mouse1.53008881
42P300_19829295_ChIP-Seq_ESCs_Human1.52083190
43ER_23166858_ChIP-Seq_MCF-7_Human1.52020592
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51353033
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50233196
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49075345
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.46148045
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45294085
49* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44613625
50* STAT3_23295773_ChIP-Seq_U87_Human1.44269417
51FUS_26573619_Chip-Seq_HEK293_Human1.43824987
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42935887
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42884804
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42156863
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.41751131
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41579842
57* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39880345
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39603512
59* TCF4_23295773_ChIP-Seq_U87_Human1.38714647
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38630873
61IRF1_19129219_ChIP-ChIP_H3396_Human1.38446430
62* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37488514
63* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37114504
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.36544456
65EWS_26573619_Chip-Seq_HEK293_Human1.33145487
66IGF1R_20145208_ChIP-Seq_DFB_Human1.31588642
67MYB_26560356_Chip-Seq_TH1_Human1.31013567
68* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30000960
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29140313
70CBP_20019798_ChIP-Seq_JUKART_Human1.29140313
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26969642
72* TP53_18474530_ChIP-ChIP_U2OS_Human1.25680743
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.25615815
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25088779
75TCF7_22412390_ChIP-Seq_EML_Mouse1.23751520
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23701841
77* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23328668
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.22933890
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22410282
80SPI1_23127762_ChIP-Seq_K562_Human1.21260119
81* SMAD4_21799915_ChIP-Seq_A2780_Human1.21043593
82* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20961314
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20959110
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.20943405
85* ARNT_22903824_ChIP-Seq_MCF-7_Human1.20497589
86RXR_22108803_ChIP-Seq_LS180_Human1.18549366
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18411629
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18358524
89MAF_26560356_Chip-Seq_TH1_Human1.17668405
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16980727
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16324977
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15344614
93UTX_26944678_Chip-Seq_JUKART_Human1.13225742
94MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12308319
95* AHR_22903824_ChIP-Seq_MCF-7_Human1.11849475
96* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11739730
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11187315
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10756815
99EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10756815
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.08308942
101E2F7_22180533_ChIP-Seq_HELA_Human1.08169724
102KDM2B_26808549_Chip-Seq_REH_Human1.08015396
103JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07102403
104* SOX2_19829295_ChIP-Seq_ESCs_Human1.06663718
105* NANOG_19829295_ChIP-Seq_ESCs_Human1.06663718
106* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05959923
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05731217
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.05550864
109RUNX2_22187159_ChIP-Seq_PCA_Human1.05427608
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.05361161
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04985760
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04840763
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04369522
114TCF4_22108803_ChIP-Seq_LS180_Human1.04188973
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03996154
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.03313496
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.02770944
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02504536
119CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02255941
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00629236
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.00482583
122VDR_24763502_ChIP-Seq_THP-1_Human1.00287215
123TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99904872
124NANOG_18555785_Chip-Seq_ESCs_Mouse0.98629550
125BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98149504
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97875715
127P53_22387025_ChIP-Seq_ESCs_Mouse0.97584238
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97161478
129TP53_16413492_ChIP-PET_HCT116_Human0.95427106
130TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95376149
131* SPI1_23547873_ChIP-Seq_NB4_Human0.95370198
132ELK1_19687146_ChIP-ChIP_HELA_Human0.95008762
133DROSHA_22980978_ChIP-Seq_HELA_Human0.94816939
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94461936
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94461936
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94400302
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.94277087
138* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94166213
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94154608
140VDR_24787735_ChIP-Seq_THP-1_Human0.93809794
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.93505287
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.92285890
143* GATA3_27048872_Chip-Seq_THYMUS_Human0.91503165
144AR_25329375_ChIP-Seq_VCAP_Human0.91195636
145EED_16625203_ChIP-ChIP_MESCs_Mouse0.90564681
146MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89959826
147NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89943843
148RNF2_27304074_Chip-Seq_NSC_Mouse0.89788508

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.91091359
2MP0003646_muscle_fatigue3.84953119
3MP0002822_catalepsy3.09782116
4MP0001188_hyperpigmentation2.86309716
5MP0003763_abnormal_thymus_physiology2.75189456
6MP0003787_abnormal_imprinting2.58603055
7MP0001800_abnormal_humoral_immune2.50521070
8MP0001835_abnormal_antigen_presentation2.48174212
9MP0005671_abnormal_response_to2.44470436
10MP0003880_abnormal_central_pattern2.40452507
11MP0003303_peritoneal_inflammation2.40075532
12MP0001790_abnormal_immune_system2.38126246
13MP0005387_immune_system_phenotype2.38126246
14MP0001873_stomach_inflammation2.21835233
15MP0002166_altered_tumor_susceptibility2.16771106
16MP0002876_abnormal_thyroid_physiology2.08860791
17MP0004130_abnormal_muscle_cell2.08462726
18MP0005409_darkened_coat_color2.06793036
19MP0004808_abnormal_hematopoietic_stem2.04833961
20MP0009379_abnormal_foot_pigmentation2.04639591
21* MP0002452_abnormal_antigen_presenting2.01585746
22MP0002009_preneoplasia2.01222987
23MP0006072_abnormal_retinal_apoptosis2.00316401
24MP0002160_abnormal_reproductive_system1.98333506
25MP0006292_abnormal_olfactory_placode1.96246461
26MP0004142_abnormal_muscle_tone1.95005367
27MP0004859_abnormal_synaptic_plasticity1.94499308
28* MP0002398_abnormal_bone_marrow1.93288241
29* MP0002420_abnormal_adaptive_immunity1.92103382
30MP0005000_abnormal_immune_tolerance1.91641897
31MP0002396_abnormal_hematopoietic_system1.90276971
32MP0006054_spinal_hemorrhage1.89842298
33MP0005551_abnormal_eye_electrophysiolog1.88950919
34* MP0001819_abnormal_immune_cell1.88229550
35MP0004885_abnormal_endolymph1.86105766
36MP0000015_abnormal_ear_pigmentation1.85498275
37MP0002723_abnormal_immune_serum1.83631936
38MP0005389_reproductive_system_phenotype1.83502089
39MP0003300_gastrointestinal_ulcer1.83363439
40MP0004145_abnormal_muscle_electrophysio1.82748113
41MP0004742_abnormal_vestibular_system1.79758536
42MP0001879_abnormal_lymphatic_vessel1.77375777
43MP0002272_abnormal_nervous_system1.73954623
44MP0008877_abnormal_DNA_methylation1.73175081
45MP0002102_abnormal_ear_morphology1.72224665
46MP0000703_abnormal_thymus_morphology1.68991550
47MP0000685_abnormal_immune_system1.67775717
48MP0002006_tumorigenesis1.66999286
49MP0009278_abnormal_bone_marrow1.64321272
50MP0003195_calcinosis1.63444866
51* MP0000716_abnormal_immune_system1.60825816
52MP0001485_abnormal_pinna_reflex1.55740860
53MP0000631_abnormal_neuroendocrine_gland1.51786034
54MP0003011_delayed_dark_adaptation1.50945199
55MP0005379_endocrine/exocrine_gland_phen1.48979900
56MP0008872_abnormal_physiological_respon1.48908639
57MP0003879_abnormal_hair_cell1.48336760
58MP0009745_abnormal_behavioral_response1.47924950
59MP0002733_abnormal_thermal_nociception1.45921351
60MP0003635_abnormal_synaptic_transmissio1.45766815
61MP0005174_abnormal_tail_pigmentation1.45516388
62MP0002148_abnormal_hypersensitivity_rea1.43453355
63MP0008775_abnormal_heart_ventricle1.41943167
64MP0009046_muscle_twitch1.39406983
65MP0000689_abnormal_spleen_morphology1.39367068
66MP0009785_altered_susceptibility_to1.37009761
67MP0002722_abnormal_immune_system1.35649227
68MP0002063_abnormal_learning/memory/cond1.33272721
69MP0001970_abnormal_pain_threshold1.32274968
70MP0001440_abnormal_grooming_behavior1.31762309
71MP0004510_myositis1.31196128
72MP0002653_abnormal_ependyma_morphology1.29925037
73MP0000569_abnormal_digit_pigmentation1.29026432
74MP0005397_hematopoietic_system_phenotyp1.28732826
75MP0001545_abnormal_hematopoietic_system1.28732826
76MP0002405_respiratory_system_inflammati1.26789511
77MP0010155_abnormal_intestine_physiology1.26049966
78* MP0002429_abnormal_blood_cell1.25036833
79MP0001968_abnormal_touch/_nociception1.24368949
80MP0003183_abnormal_peptide_metabolism1.24357098
81MP0001905_abnormal_dopamine_level1.23652083
82MP0005025_abnormal_response_to1.23165531
83MP0001348_abnormal_lacrimal_gland1.22897520
84MP0000230_abnormal_systemic_arterial1.22781756
85MP0006276_abnormal_autonomic_nervous1.22381019
86MP0002638_abnormal_pupillary_reflex1.21415597
87MP0008961_abnormal_basal_metabolism1.20569261
88MP0005645_abnormal_hypothalamus_physiol1.20238605
89MP0003724_increased_susceptibility_to1.16212449
90MP0005253_abnormal_eye_physiology1.15520114
91MP0002067_abnormal_sensory_capabilities1.15059507
92MP0004133_heterotaxia1.13899639
93MP0003866_abnormal_defecation1.12320462
94MP0002419_abnormal_innate_immunity1.09988492
95MP0002572_abnormal_emotion/affect_behav1.08763232
96MP0005084_abnormal_gallbladder_morpholo1.08222463
97MP0002095_abnormal_skin_pigmentation1.07654618
98MP0010386_abnormal_urinary_bladder1.07009446
99MP0002163_abnormal_gland_morphology1.06934525
100MP0003136_yellow_coat_color1.06299829
101MP0003091_abnormal_cell_migration1.06095866
102MP0001986_abnormal_taste_sensitivity1.05612668
103MP0000026_abnormal_inner_ear1.02712929
104MP0003436_decreased_susceptibility_to1.02561622
105MP0009780_abnormal_chondrocyte_physiolo1.02304135
106MP0001919_abnormal_reproductive_system1.01648278
107MP0002938_white_spotting1.01532607
108MP0000465_gastrointestinal_hemorrhage1.01480286
109MP0003943_abnormal_hepatobiliary_system1.00886586
110MP0009250_abnormal_appendicular_skeleto1.00050281
111MP0003633_abnormal_nervous_system0.99783634
112MP0000372_irregular_coat_pigmentation0.98919068
113MP0005503_abnormal_tendon_morphology0.96077437
114MP0002735_abnormal_chemical_nociception0.95838306
115MP0003283_abnormal_digestive_organ0.95663521
116MP0002933_joint_inflammation0.94647544
117MP0004215_abnormal_myocardial_fiber0.92885787
118MP0005195_abnormal_posterior_eye0.92485840
119MP0000049_abnormal_middle_ear0.91777322
120MP0002693_abnormal_pancreas_physiology0.91691447
121MP0002909_abnormal_adrenal_gland0.89469163
122MP0003279_aneurysm0.88303872
123MP0002184_abnormal_innervation0.87041225
124MP0000427_abnormal_hair_cycle0.86975489
125MP0000490_abnormal_crypts_of0.86865256
126MP0003937_abnormal_limbs/digits/tail_de0.86405675
127MP0003938_abnormal_ear_development0.86231631
128MP0003122_maternal_imprinting0.86194648
129MP0001944_abnormal_pancreas_morphology0.85546918
130MP0005646_abnormal_pituitary_gland0.85428987
131MP0001765_abnormal_ion_homeostasis0.84902473
132MP0000383_abnormal_hair_follicle0.83639091
133MP0002752_abnormal_somatic_nervous0.82906654
134MP0008995_early_reproductive_senescence0.82504751
135MP0005386_behavior/neurological_phenoty0.82355513
136MP0004924_abnormal_behavior0.82355513
137MP0005464_abnormal_platelet_physiology0.82320503
138MP0002277_abnormal_respiratory_mucosa0.81988509
139MP0001502_abnormal_circadian_rhythm0.81439194
140MP0001853_heart_inflammation0.81152055
141MP0008007_abnormal_cellular_replicative0.79652589
142MP0002229_neurodegeneration0.79191176
143MP0001529_abnormal_vocalization0.78832801
144MP0005410_abnormal_fertilization0.78259325
145MP0002736_abnormal_nociception_after0.77976812
146MP0009764_decreased_sensitivity_to0.77744296
147MP0002557_abnormal_social/conspecific_i0.75975491
148MP0002138_abnormal_hepatobiliary_system0.75567691
149MP0009333_abnormal_splenocyte_physiolog0.75363357
150MP0005367_renal/urinary_system_phenotyp0.75332688
151MP0000516_abnormal_urinary_system0.75332688
152MP0003121_genomic_imprinting0.75034763
153MP0001845_abnormal_inflammatory_respons0.74865301
154MP0005310_abnormal_salivary_gland0.74089066
155MP0003828_pulmonary_edema0.73300823
156MP0001501_abnormal_sleep_pattern0.72077658
157MP0004270_analgesia0.68945959
158MP0005075_abnormal_melanosome_morpholog0.68659551
159MP0002064_seizures0.68581991
160MP0001486_abnormal_startle_reflex0.67920820
161MP0002877_abnormal_melanocyte_morpholog0.67051219
162MP0010234_abnormal_vibrissa_follicle0.66408618
163MP0004883_abnormal_blood_vessel0.65959960
164MP0000767_abnormal_smooth_muscle0.63514848
165MP0002928_abnormal_bile_duct0.62359438
166MP0004947_skin_inflammation0.62309745
167MP0001663_abnormal_digestive_system0.62064425
168MP0000778_abnormal_nervous_system0.60392119

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.68746989
2Pancreatic cysts (HP:0001737)3.91338432
3Genetic anticipation (HP:0003743)3.77921501
4Progressive cerebellar ataxia (HP:0002073)3.71389530
5Nephronophthisis (HP:0000090)3.69279677
6Molar tooth sign on MRI (HP:0002419)3.61743079
7Abnormality of midbrain morphology (HP:0002418)3.61743079
8Congenital stationary night blindness (HP:0007642)3.59667596
9Panhypogammaglobulinemia (HP:0003139)3.51758369
10Recurrent bronchitis (HP:0002837)3.47253933
11Pancreatic fibrosis (HP:0100732)3.42534313
12Chronic sinusitis (HP:0011109)3.38021406
13Abnormality of the renal medulla (HP:0100957)3.32169010
14True hermaphroditism (HP:0010459)3.29192688
15Cellulitis (HP:0100658)3.17943227
16Decreased circulating renin level (HP:0003351)3.15727154
17B lymphocytopenia (HP:0010976)3.10695861
18Abnormality of B cell number (HP:0010975)3.10695861
19Thyroiditis (HP:0100646)3.09476659
20Agitation (HP:0000713)3.06291811
21Meningitis (HP:0001287)3.05500505
22Recurrent viral infections (HP:0004429)3.04585589
23Papilloma (HP:0012740)2.87946039
24Verrucae (HP:0200043)2.87946039
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.87555699
26Retrobulbar optic neuritis (HP:0100654)2.86476880
27Optic neuritis (HP:0100653)2.86476880
28Thyroid-stimulating hormone excess (HP:0002925)2.85300516
29IgM deficiency (HP:0002850)2.84487494
30Abnormality of the phalanges of the 2nd finger (HP:0009541)2.82052148
31Abnormality of the renal cortex (HP:0011035)2.79887751
32Gaze-evoked nystagmus (HP:0000640)2.78169560
33Abnormal rod and cone electroretinograms (HP:0008323)2.77072695
34Tubular atrophy (HP:0000092)2.72008874
35Abnormality of the fingertips (HP:0001211)2.70461275
36Colitis (HP:0002583)2.64959810
37Elevated erythrocyte sedimentation rate (HP:0003565)2.64396775
38T lymphocytopenia (HP:0005403)2.62133749
39Abnormality of the proximal phalanges of the hand (HP:0009834)2.61727414
40Myositis (HP:0100614)2.61695926
41Absent/shortened dynein arms (HP:0200106)2.59519022
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.59519022
43Abnormal ciliary motility (HP:0012262)2.59215654
44Distal lower limb amyotrophy (HP:0008944)2.58610042
45Inflammation of the large intestine (HP:0002037)2.58072792
46Recurrent fungal infections (HP:0002841)2.57788787
47Papilledema (HP:0001085)2.55973084
48Limb dystonia (HP:0002451)2.55541163
49Abnormality of T cell number (HP:0011839)2.55069389
50Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.52687144
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.52097931
52Abolished electroretinogram (ERG) (HP:0000550)2.50429260
53Volvulus (HP:0002580)2.49210023
54Chronic otitis media (HP:0000389)2.48516613
55Gastrointestinal inflammation (HP:0004386)2.48459259
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.45587934
57Keratoconus (HP:0000563)2.45379424
58Increased corneal curvature (HP:0100692)2.45379424
59Congenital, generalized hypertrichosis (HP:0004540)2.42961536
60Concave nail (HP:0001598)2.42193132
61Abnormal respiratory epithelium morphology (HP:0012253)2.41189740
62Abnormal respiratory motile cilium morphology (HP:0005938)2.41189740
63Recurrent sinusitis (HP:0011108)2.39827037
64Cystic liver disease (HP:0006706)2.39619518
65Keratoconjunctivitis sicca (HP:0001097)2.39605666
66Vertebral arch anomaly (HP:0008438)2.38603981
67Abnormality of the phalanges of the 5th finger (HP:0004213)2.36576582
68Abnormal hair whorl (HP:0010721)2.35995428
69Large for gestational age (HP:0001520)2.35602626
70Protruding tongue (HP:0010808)2.34833787
71Focal motor seizures (HP:0011153)2.34424165
72Stomach cancer (HP:0012126)2.33170939
73Spontaneous hematomas (HP:0007420)2.31538408
74Chronic hepatic failure (HP:0100626)2.30048671
75Furrowed tongue (HP:0000221)2.29008425
76Symphalangism affecting the phalanges of the hand (HP:0009773)2.28560118
77Medial flaring of the eyebrow (HP:0010747)2.28471100
78Pendular nystagmus (HP:0012043)2.25817190
79Orchitis (HP:0100796)2.25797034
80Lymphopenia (HP:0001888)2.25733026
81Asplenia (HP:0001746)2.24645357
82Bony spicule pigmentary retinopathy (HP:0007737)2.23039845
83Aplasia/Hypoplasia of the spleen (HP:0010451)2.22952146
84IgA deficiency (HP:0002720)2.22122448
85Recurrent cutaneous fungal infections (HP:0011370)2.21274982
86Chronic mucocutaneous candidiasis (HP:0002728)2.21274982
87Recurrent abscess formation (HP:0002722)2.20800033
88Abnormality of the nasal septum (HP:0000419)2.20483982
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19731544
90Short 4th metacarpal (HP:0010044)2.19731544
91Vasculitis (HP:0002633)2.19357118
92Gastrointestinal stroma tumor (HP:0100723)2.18541323
93Abnormality of cells of the lymphoid lineage (HP:0012140)2.18219997
94Abnormal respiratory motile cilium physiology (HP:0012261)2.17414739
95Short hallux (HP:0010109)2.16274646
96IgG deficiency (HP:0004315)2.15388911
97Abnormality of the middle phalanges of the toes (HP:0010183)2.14956575
98Abnormality of the intervertebral disk (HP:0005108)2.13962805
99Aplasia/Hypoplasia of the fibula (HP:0006492)2.13300369
100Osteomalacia (HP:0002749)2.13039473
101Febrile seizures (HP:0002373)2.12478500
102Severe combined immunodeficiency (HP:0004430)2.12225962
103Decreased central vision (HP:0007663)2.12021758
104Spinal cord lesions (HP:0100561)2.10940867
105Syringomyelia (HP:0003396)2.10940867
106Fibular aplasia (HP:0002990)2.10464952
107Hypoplasia of the uterus (HP:0000013)2.10126018
108Attenuation of retinal blood vessels (HP:0007843)2.09840497
109Oligodontia (HP:0000677)2.09687407
110Heterochromia iridis (HP:0001100)2.09381619
111Keratoconjunctivitis (HP:0001096)2.08398804
112Aplasia/hypoplasia of the uterus (HP:0008684)2.06811424
113Metabolic alkalosis (HP:0200114)2.06119687
114Abnormal drinking behavior (HP:0030082)2.06057556
115Polydipsia (HP:0001959)2.06057556
116Abnormality of T cells (HP:0002843)2.05190443
117Osteomyelitis (HP:0002754)2.03945788
118Short femoral neck (HP:0100864)2.03933186
119Lower limb amyotrophy (HP:0007210)2.03491340
120Clumsiness (HP:0002312)2.03020111
121Aplasia/Hypoplasia of the hallux (HP:0008362)2.01348534
122Thrombocytosis (HP:0001894)2.00690528
123Short tibia (HP:0005736)1.99655024
124Type II lissencephaly (HP:0007260)1.98158508
125Megalencephaly (HP:0001355)1.97980544
126Acute lymphatic leukemia (HP:0006721)1.97474332
127Hematochezia (HP:0002573)1.96469210
128Abnormality of oral frenula (HP:0000190)1.96367406
129Hypothermia (HP:0002045)1.96186953
130Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.96175286
131Bronchitis (HP:0012387)1.96044020
132Chorioretinal atrophy (HP:0000533)1.95121331
133Increased IgE level (HP:0003212)1.94884341
134Hyperventilation (HP:0002883)1.93199907
135Intestinal atresia (HP:0011100)1.92103724
136Conjunctival hamartoma (HP:0100780)1.91576435
137Male pseudohermaphroditism (HP:0000037)1.91208102
138Mesomelia (HP:0003027)1.91017035
139Broad-based gait (HP:0002136)1.89011220
140Methylmalonic acidemia (HP:0002912)1.88669361
141Abnormality of the columella (HP:0009929)1.87876538
142Stomatitis (HP:0010280)1.87852825
143Sepsis (HP:0100806)1.87748076
144Hypoplasia of the ulna (HP:0003022)1.87538373
145Absent frontal sinuses (HP:0002688)1.86717710
146Anencephaly (HP:0002323)1.86369415
147Atonic seizures (HP:0010819)1.84672561
148Pigmentary retinal degeneration (HP:0001146)1.84576630
149Epileptic encephalopathy (HP:0200134)1.84416460
150Abnormal pancreas size (HP:0012094)1.82599386
151Widely spaced teeth (HP:0000687)1.82599017
152Hemoptysis (HP:0002105)1.81905281
153Gait imbalance (HP:0002141)1.81901393
154Fibular hypoplasia (HP:0003038)1.81662844
155Long palpebral fissure (HP:0000637)1.80897702
156Abnormality of the 4th metacarpal (HP:0010012)1.80365812
157Sclerocornea (HP:0000647)1.79346371
158Palpebral edema (HP:0100540)1.79200282
159Goiter (HP:0000853)1.78705601
160Encephalitis (HP:0002383)1.78517662
161Bulbous nose (HP:0000414)1.78510516
162Fair hair (HP:0002286)1.78325654
163Congenital sensorineural hearing impairment (HP:0008527)1.77947494
164Renal cortical cysts (HP:0000803)1.76858912
1653-Methylglutaconic aciduria (HP:0003535)1.76606719
166Ankyloglossia (HP:0010296)1.76209011
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75629829
168Abnormality of renin-angiotensin system (HP:0000847)1.75120243
169* Pulmonary infiltrates (HP:0002113)1.74544401
170Polyuria (HP:0000103)1.73733711
171Acute myeloid leukemia (HP:0004808)1.73486042
172Slow-growing hair (HP:0002217)1.73338023
173Abnormality of hair growth rate (HP:0011363)1.73338023
174* Stereotypic behavior (HP:0000733)1.73215558
175Aortic regurgitation (HP:0001659)1.71958836
176Hemiparesis (HP:0001269)1.71954813
177Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.71917202
178Generalized hypopigmentation of hair (HP:0011358)1.71735144
179* Mediastinal lymphadenopathy (HP:0100721)1.71417662
180Annular pancreas (HP:0001734)1.71231539
181Cutis marmorata (HP:0000965)1.70545397
182Long eyelashes (HP:0000527)1.69133300
183Chest pain (HP:0100749)1.68797645
184Amblyopia (HP:0000646)1.68755682
185Obstructive lung disease (HP:0006536)1.68741947
186Chronic obstructive pulmonary disease (HP:0006510)1.68741947
187Arterial thrombosis (HP:0004420)1.68469628
188Eczematoid dermatitis (HP:0000976)1.64780929
189Recurrent pneumonia (HP:0006532)1.64725589
190Chronic diarrhea (HP:0002028)1.63907399
191Exotropia (HP:0000577)1.63431885
192Focal seizures (HP:0007359)1.62742294
193Viral hepatitis (HP:0006562)1.61719087
194Lymphoma (HP:0002665)1.60589089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.73814863
2SIK33.54242988
3EPHA43.35756747
4MAP4K13.22476733
5CASK3.02666257
6TXK2.63535891
7TAOK32.48590147
8MAP3K122.36797845
9PINK12.31728444
10SIK22.27077364
11NLK2.17233018
12BMPR22.08232247
13MAP3K141.98176018
14FES1.84901634
15WNK41.78006797
16SYK1.75671152
17GRK61.72586565
18WNK31.67596701
19PAK31.59754598
20MAP3K101.58732209
21TEC1.57277967
22MAP3K131.54178039
23NTRK31.53910858
24ADRBK11.40089572
25MAP3K41.37433415
26SGK21.35837275
27IRAK41.34697611
28INSRR1.33316196
29BRD41.32821873
30IKBKE1.32448640
31PRPF4B1.31145094
32ITK1.28736683
33NTRK21.27665017
34DAPK11.27415607
35FGFR31.26342881
36CLK11.24648468
37STK391.22484463
38MAPK131.22087014
39MARK11.21503221
40JAK31.16771321
41BTK1.16000184
42MAPK151.14929580
43PNCK1.11600760
44PIM21.11141493
45MAP4K21.10779475
46ZAP701.10347504
47PLK21.10080442
48FRK1.08864635
49PHKG21.07564277
50PHKG11.07564277
51PRKCG1.06084766
52PIK3CA1.05270294
53GRK71.04028861
54RAF11.03824542
55KIT1.03522415
56DAPK21.03211698
57MKNK21.01898727
58DYRK21.00406143
59TGFBR10.97617498
60HCK0.97402535
61KSR10.95468520
62TLK10.94762698
63TNK20.94683171
64TYRO30.89651280
65PRKCQ0.89404577
66LCK0.89169899
67MAPK70.87952906
68MAPKAPK30.86900946
69YES10.86270943
70MARK20.85801156
71STK110.84598304
72CDK90.84576898
73PRKCE0.83590598
74IKBKB0.82566156
75MAP3K90.82498463
76CHUK0.81376556
77GRK50.79942530
78SGK30.79897229
79LYN0.79548292
80MINK10.78851130
81PIM10.76812715
82DMPK0.76512363
83NUAK10.76407761
84ERBB20.74970030
85EEF2K0.74862745
86CCNB10.74686421
87BMPR1B0.74204248
88MELK0.72885789
89OXSR10.72116617
90IRAK10.72054281
91BLK0.70205029
92MAP2K70.70162200
93CAMK2A0.68906160
94CDK190.68023652
95HIPK20.67967266
96TNIK0.66606494
97MAP2K20.66209748
98PIK3CG0.64109008
99PRKACA0.62191199
100CDK80.62037452
101RPS6KA60.61776105
102DYRK1A0.61553981
103MAP2K60.61311175
104MST40.61220587
105STK160.59995672
106PTK2B0.59162340
107MAPKAPK50.58644019
108SGK4940.57940084
109SGK2230.57940084
110PRKD20.56393032
111TIE10.55763964
112PRKCZ0.53895912
113CAMKK20.53797558
114MKNK10.50967606
115EPHB20.50774884
116CAMK40.49967277
117CAMK10.49773647
118FGFR20.49065615
119CSK0.48919023
120JAK10.48750628
121MARK30.48069256
122ERBB30.47937833
123UHMK10.47502253
124SGK10.47467833
125PKN10.47309602
126TGFBR20.45432550
127AKT30.45142466
128TRPM70.44858657
129STK380.44691751
130STK100.44045792
131ADRBK20.43857157
132CSF1R0.43036811
133MAPK40.42486490
134DYRK30.42454411
135ARAF0.42300124
136BCR0.41637055
137STK38L0.41395888
138ACVR1B0.41180353
139MAP2K10.41103259
140TYK20.38780702
141TAF10.38619333
142MUSK0.38477186
143CDK50.38226568
144PRKCA0.37254015
145CAMKK10.37204223
146PRKACG0.36780990
147RPS6KA20.36741046
148PRKG10.36412503
149FYN0.36334524
150GRK10.35832339
151ZAK0.33634419

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.81526888
2Primary immunodeficiency_Homo sapiens_hsa053402.43729889
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.31127457
4B cell receptor signaling pathway_Homo sapiens_hsa046622.07343882
5Linoleic acid metabolism_Homo sapiens_hsa005911.95136019
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92669765
7Dorso-ventral axis formation_Homo sapiens_hsa043201.77956871
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72781837
9Nitrogen metabolism_Homo sapiens_hsa009101.70833574
10Long-term potentiation_Homo sapiens_hsa047201.70186769
11T cell receptor signaling pathway_Homo sapiens_hsa046601.62152918
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61030341
13Olfactory transduction_Homo sapiens_hsa047401.58070544
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.57798638
15Morphine addiction_Homo sapiens_hsa050321.48448373
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48379432
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.44467841
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.41345842
19Amphetamine addiction_Homo sapiens_hsa050311.38220500
20Nicotine addiction_Homo sapiens_hsa050331.38113853
21Tryptophan metabolism_Homo sapiens_hsa003801.34532331
22Cardiac muscle contraction_Homo sapiens_hsa042601.34081158
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30491080
24Oxidative phosphorylation_Homo sapiens_hsa001901.27618046
25Osteoclast differentiation_Homo sapiens_hsa043801.27074918
26Leishmaniasis_Homo sapiens_hsa051401.25963245
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.24110398
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21672387
29Circadian entrainment_Homo sapiens_hsa047131.21095249
30Hematopoietic cell lineage_Homo sapiens_hsa046401.20331210
31Type II diabetes mellitus_Homo sapiens_hsa049301.18833006
32Measles_Homo sapiens_hsa051621.17023485
33Renin secretion_Homo sapiens_hsa049241.15031233
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14669219
35Chemical carcinogenesis_Homo sapiens_hsa052041.14363184
36Dopaminergic synapse_Homo sapiens_hsa047281.14356788
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14247436
38Allograft rejection_Homo sapiens_hsa053301.13865165
39Non-small cell lung cancer_Homo sapiens_hsa052231.12254876
40Chemokine signaling pathway_Homo sapiens_hsa040621.10342479
41Retinol metabolism_Homo sapiens_hsa008301.09877142
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09205038
43Cholinergic synapse_Homo sapiens_hsa047251.08034218
44Shigellosis_Homo sapiens_hsa051311.07888983
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06210969
46Glycerolipid metabolism_Homo sapiens_hsa005611.05514322
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04927031
48Glutamatergic synapse_Homo sapiens_hsa047241.04380830
49Parkinsons disease_Homo sapiens_hsa050121.04039347
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03501186
51African trypanosomiasis_Homo sapiens_hsa051431.02928434
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02492408
53Oxytocin signaling pathway_Homo sapiens_hsa049211.01885248
54Ether lipid metabolism_Homo sapiens_hsa005651.01523415
55Regulation of autophagy_Homo sapiens_hsa041401.01465656
56Platelet activation_Homo sapiens_hsa046111.00540256
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98940610
58Cocaine addiction_Homo sapiens_hsa050300.98644320
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97863824
60Butanoate metabolism_Homo sapiens_hsa006500.97532579
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.96636186
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96427528
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96409073
64Hepatitis B_Homo sapiens_hsa051610.96391410
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95813288
66Glioma_Homo sapiens_hsa052140.93591650
67Chronic myeloid leukemia_Homo sapiens_hsa052200.93588128
68Colorectal cancer_Homo sapiens_hsa052100.93110986
69Non-homologous end-joining_Homo sapiens_hsa034500.93037029
70Long-term depression_Homo sapiens_hsa047300.92205978
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90819711
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90668380
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90337701
74Basal transcription factors_Homo sapiens_hsa030220.89834374
75Serotonergic synapse_Homo sapiens_hsa047260.89049151
76Acute myeloid leukemia_Homo sapiens_hsa052210.88994420
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.88513453
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88183082
79Protein export_Homo sapiens_hsa030600.88066877
80Salivary secretion_Homo sapiens_hsa049700.88042640
81Caffeine metabolism_Homo sapiens_hsa002320.87719065
82Sulfur metabolism_Homo sapiens_hsa009200.87621632
83Pancreatic cancer_Homo sapiens_hsa052120.87616156
84Calcium signaling pathway_Homo sapiens_hsa040200.86874649
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84726055
86Arachidonic acid metabolism_Homo sapiens_hsa005900.84202564
87Alzheimers disease_Homo sapiens_hsa050100.83484132
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.81345125
89MAPK signaling pathway_Homo sapiens_hsa040100.81007407
90ABC transporters_Homo sapiens_hsa020100.80431426
91Taste transduction_Homo sapiens_hsa047420.80156398
92Tuberculosis_Homo sapiens_hsa051520.79185249
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77910796
94cAMP signaling pathway_Homo sapiens_hsa040240.77820099
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77464767
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.77396756
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76990185
98VEGF signaling pathway_Homo sapiens_hsa043700.76036944
99Graft-versus-host disease_Homo sapiens_hsa053320.75562534
100Viral myocarditis_Homo sapiens_hsa054160.75151936
101Autoimmune thyroid disease_Homo sapiens_hsa053200.74676139
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74662311
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74401395
104Antigen processing and presentation_Homo sapiens_hsa046120.74169723
105HTLV-I infection_Homo sapiens_hsa051660.73848457
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73805193
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73733517
108Adherens junction_Homo sapiens_hsa045200.73443013
109Alcoholism_Homo sapiens_hsa050340.73408293
110Gastric acid secretion_Homo sapiens_hsa049710.73390866
111Herpes simplex infection_Homo sapiens_hsa051680.72558744
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72224674
113Influenza A_Homo sapiens_hsa051640.72133965
114Type I diabetes mellitus_Homo sapiens_hsa049400.71705775
115Salmonella infection_Homo sapiens_hsa051320.71272422
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71233481
117GnRH signaling pathway_Homo sapiens_hsa049120.70979980
118Rap1 signaling pathway_Homo sapiens_hsa040150.70975891
119Thyroid cancer_Homo sapiens_hsa052160.70630909
120Toxoplasmosis_Homo sapiens_hsa051450.69774456
121TNF signaling pathway_Homo sapiens_hsa046680.69737886
122ErbB signaling pathway_Homo sapiens_hsa040120.69335941
123Pertussis_Homo sapiens_hsa051330.69265822
124Axon guidance_Homo sapiens_hsa043600.68222589
125Gap junction_Homo sapiens_hsa045400.67446902
126Insulin secretion_Homo sapiens_hsa049110.66845685
127Ovarian steroidogenesis_Homo sapiens_hsa049130.66365050
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65080790
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64844459
130Melanogenesis_Homo sapiens_hsa049160.64428825
131Endometrial cancer_Homo sapiens_hsa052130.64068748
132Estrogen signaling pathway_Homo sapiens_hsa049150.63073272
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62730278
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62332678
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61491410
136GABAergic synapse_Homo sapiens_hsa047270.61346943
137Prostate cancer_Homo sapiens_hsa052150.61055444
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60460480
139FoxO signaling pathway_Homo sapiens_hsa040680.60154868
140Huntingtons disease_Homo sapiens_hsa050160.59760181
141Asthma_Homo sapiens_hsa053100.59444417
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57436679
143RNA degradation_Homo sapiens_hsa030180.56355164
144Hedgehog signaling pathway_Homo sapiens_hsa043400.56352750
145Ribosome_Homo sapiens_hsa030100.54396725
146Insulin resistance_Homo sapiens_hsa049310.53230007
147RNA polymerase_Homo sapiens_hsa030200.52510322
148Histidine metabolism_Homo sapiens_hsa003400.52290121
149Ras signaling pathway_Homo sapiens_hsa040140.51613200
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51546520
151Melanoma_Homo sapiens_hsa052180.49552163
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48628135
153Circadian rhythm_Homo sapiens_hsa047100.47846431
154Fat digestion and absorption_Homo sapiens_hsa049750.45678703
155Basal cell carcinoma_Homo sapiens_hsa052170.45234529
156Primary bile acid biosynthesis_Homo sapiens_hsa001200.45211933
157Peroxisome_Homo sapiens_hsa041460.44520643
158Vitamin digestion and absorption_Homo sapiens_hsa049770.43957164
159Selenocompound metabolism_Homo sapiens_hsa004500.41748022

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